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Narcotic strength chart: Table A6.2, Approximate potency of opioids relative to morphine; PO and immediate-release formulations unless stated otherwisea – WHO Guidelines for the Pharmacological and Radiotherapeutic Management of Cancer Pain in Adults and Adolescents

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Table A6.2, Approximate potency of opioids relative to morphine; PO and immediate-release formulations unless stated otherwisea – WHO Guidelines for the Pharmacological and Radiotherapeutic Management of Cancer Pain in Adults and Adolescents

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WHO Guidelines for the Pharmacological and Radiotherapeutic Management of Cancer Pain in Adults and Adolescents. Geneva: World Health Organization; 2018.

WHO Guidelines for the Pharmacological and Radiotherapeutic Management of Cancer Pain in Adults and Adolescents.

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Table A6.2Approximate potency of opioids relative to morphine; PO and immediate-release formulations unless stated otherwise

a

Source: Adapted with permission from Twycross et al. 2017:371 (Table 4) (3).

a

Multiply dose of opioid in the first column by relative potency in the second column to determine the equivalent dose of morphine sulfate/hydrochloride; conversely, divide morphine dose by the relative potency to determine the equivalent dose of another opioid.

b

Dependent in part on severity of pain and on dose; often longer-lasting in very elderly and those with renal impairment.

c

The numbers in parenthesis are the manufacturers’ preferred relative potencies.

d

A single 5 mg dose of methadone is equivalent to morphine 7.5 mg, but a variable long plasma half-life and broad-spectrum receptor affinity result in a much higher-than-expected relative potency when administered regularly – sometimes much higher than the range given above. Therefore, guidance from a specialist is recommended for conversions to regularly administered methadone.

From: ANNEX 6, Pharmacological Profiles and Opioid Conversion Tables

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Equianalgesic Chart (Changes in italics)








Route

Starting Dose

(Adults > 50 Kg)

Onset

Peak

Duration

Metabolism

Half Life

Comments

Codeine

PO

IM

SQ

30
– 60 mg q 4 hr

15
– 30 mg q 4 hr

15
– 30 mg q 4 hr

30
min

15
– 30 min

30
– 60 min

1 hr

30
– 60 min

2
– 4 hr

6
hr

4
– 6 hr

4
– 8 hr

Liver

2
– 4 hr

IV use (even at low doses and when given very slowly)
may cause marked decrease in blood pressure; IV use is not recommended.

IM or SQ routes are the preferred
parenteral routes.

Fentanyl

(Sublimaze)

 

 

(Duragesic)

 

 

IM

IV

 

 

Trans-dermal

 

5
mcg/Kg q 1 – 2 hr

0.25
– 1 mcg/Kg as needed

 

25
mcg/hr

 

 

7
– 8 min

Immediate

 

 

12
– 24 hr

20
– 50 min

1
– 5 min

 

 

24
hr

1
– 2 hr

30
– 60 min

48
– 72 hr

Liver

1
– 6 hr*

Transdermal should NOT be used to treat
acute pain.

Transdermal patch should
be used only in opioid tolerant patients.
Effects of patch last for 18 – 24 hours after the patch is removed.

Use of IV fentanyl is
restricted to Oncology, Burn Service, Palliative Care, Intensive Care Units
or based on recommendation by the Pain Service. Appropriate monitoring is required. Refer
to Nursing Policies 8.021 and 8.025.

Hydrocodone with acetaminophen**

(Lortab, Vicodin)

PO

5
– 10 mg hydrocodone q 4 – 6 hr

60
min

2
hr

4
– 6 hr

Liver

4
hr

Available
at UIHC as:

Tablet with 5 mg hydrocodone and 500 mg
acetaminophen.

Elixir with 2.5 mg hydrocodone and 167 mg
acetaminophen

per 5 ml.

Hydromorphone

(Dilaudid)

 

 

PO

IM/SQ

Slow
IV

 

2
– 4 mg q 4 – 6 hr

2
mg q 4 – 6 hr

0.2
– 0.6
mg
q 2 – 3 hr

 

30
min

15
– 20 min

15
– 20 min


60
min

60
min

60
min

 

4
– 5 hr

4
– 5 hr

4
– 5 hr

 

Liver

2 – 3 hr

 

 

Chronic treatment may require q 3 – 4
hour dosing.

IV doses should be administered over at
least 2-3 minutes.

 

Meperidine

(Demerol)

IM/SQ

IV

50
– 150 mg q 3-4 hr

25
– 50 mg q 1-2 hr

10
– 45 min

2
– 5 min

30
– 60 min

20
min

2
hr

2
hr

Liver


More than 72 hr of continuous use can
cause accumulation of

normeperidine which can lead to
neuroexcitability (seizures).

Naloxone administration
will increase neuroexcitibility.

Use with caution in the
elderly and patients with renal


dysfunction.

Not for use in
chronic pain.
Do not exceed 600 mg
/ 24 hours.

 






Route

Dose
(Adults > 50Kg)

Onset

Peak

Duration

Metabolism

Half Life

Comments

Methadone

(Dolophine)

PO

 

2. 5
mg 1 to 4 times daily

 

30
– 240 min

 

2
– 4 hr

 

4
– 24 hr

 

Liver

24
hr

Used in chronic pain.

Continued dosing can result in
accumulation and respiratory

depression.

Morphine

 

 

 

 

(MS Contin)

 

(Avinza)

PO/SL

IM

IV


 

PO-SR

 

PO-SR

10
– 15 mg q 3 – 4 hr

4
– 10 mg q 3 – 4 hr

2
– 4 mg q 2 – 4 hr

4
-10 mg q 3 – 4 hr

 

MS
Contin: 15 mg q 12 hr

 

Avinza: 30 mg daily

15 min

15 – 60 min

2 – 5 min

15 – 30 min

 

N/A

 

N/A

1 – 2 hr

30 – 60 min

20 min

30 – 60 min

 

N/A

 

N/A

4 hr

4 hr

3 – 4 hr

4 – 7 hr

 

8 -12 hr

 

24 hr

Liver

1. 5
– 2 hr

 

 

 

 

2
– 4 hr

 

15
hr

Oral liquid concentrate is available.

Active metabolite renally
eliminated; use caution in elderly

and
patients with renal insufficiency.

Long-acting dosage forms should not be
crushed.

  Long-acting dosage forms
should not be used to treat acute pain.

  Avinzais not on the UIHC formulary, but is used by
Medicaid.

Oxycodone

(Percocet)**

 

(OxyContin)

 

 

PO/SL

 

 

PO-SR

5
-10 mg q 4 – 6 hr-alone

or
with acetaminophen

 

OxyContin:
10 mg q 12 hr

15
– 30 min

 

 

60
min

1
– 2 hr

 

 

2
– 3 hr

4
– 6 hr

 

 

12
hr

Liver

4 hr

Available at UIHC as an
immediate-release tablet and oral

liquid concentration

Percocet contains oxycodone
5mg / acetaminophen 325mg

Other strengths of Percocet are available outside UIHC.

OxyContin is a
sustained-release tablet. Do not
crush.

OxyContin
should not be used to treat acute pain.

 

Guidelines for Patient-Controlled
Intravenous Opioid Administration (PCA) for Adults with Acute Pain

 

The amount of opioid required to
achieve comfort varies from patient to patient.
Adjust dosing to achieve patient comfort with minimal side effects.




Drug#

Usual Loading

Dose

Usual PCA Demand Bolus (Range)

Usual Lockout

Range

Usual

Basal Rate

Morphine (1 mg/ml)

5 10 mg

1 mg (0. 5 – 2.5 mg)

5 – 10 min

None or 1 – 2 mg/hr

Hydromorphone (Dilaudid) (0.2 mg/ml)

0.5 1.5 mg

0.2 mg (0.05 – 0.4 mg)

5 – 10 min

None or 0.1 – 0.4 mg/hr

Partially
adapted from the Principles of Analgesic Use in the Treatment of Acute Pain and
Cancer Pain, American Pain Society, 5th Ed. 2003.


Standard concentrations are listed in parentheses.

 

Initial Fentanyl Transdermal
Dosage (use only when converting another opioid TO fentanyl patch)*

 

 














Oral 24-hour morphine equivalent

(mg/day)


(mcg/hr)


25

135-224

50

225-314

75

315-404

100

405-494

125

495-584

150

585-674

175

675-764

200

765-854

225

855-944

250

945-1034

275

1035-1124

300

*Note: Do not use this table to convert from
fentanyl transdermal system to other opioid analgesics because these conversion
dosage recommendations are conservative.
Use of this table for conversion from fentanyl to other opioids can
overestimate the dose of the new agent and may result in an overdosage.

 

Equianalgesic Chart

 

Doses listed are equivalent to 10
mg of parenteral morphine. Doses should be titrated according to individual
response. When converting to another opioid, the dose of the new agent should
be reduced by 30-50% due to incomplete cross-tolerance between opioids.









 

Analgesic

Dosage

Parenteral

Oral

Fentanyl (Sublimaze)

0. 1 – 0.2 mg

————–

Hydrocodone

————-

30 mg

Hydromorphone (Dilaudid)

1.5 mg

7.5 mg

Meperidine (Demerol)

75 – 100 mg

300 mg (N)

Morphine

10 mg

30 mg

Oxycodone

————-

20mg

Dosage in this range may lead to
neuroexcitability.


For a single dose, 10 mg IV morphine = 60 mg oral morphine. For chronic dosing, 10 mg IV morphine = 30 mg
oral morphine.

(N)
Non-formulary at UIHC.

 

Example of opioid conversion:

    1. Bolus doses administered by the
      medical/nursing staff

2.     
The
equianalgesic chart indicates that 1.5 mg of parenteral hydromorphone equals
7.5 mg of oral hydromorphone (a 5-fold
increase).

  1. The patients current dose of 5 mg per
    day of parenteral hydromorphone is equal to 25 mg per day of oral
    hydromorphone.
  2. The next step is to convert 25 mg of
    oral hydromorphone to the daily oral morphine equivalent dose (DOMED).
  3. The equianalgesic chart indicates that
    7.5 mg of oral hydromorphone is equal to 30 mg of oral morphine.
  4. The patients calculated dose of 25 mg
    of oral hydromorphone is equal to 100 mg of oral morphine.
  5. The oral dose of morphine should be
    reduced by 30% to 50% to prevent any risk of overdose after the
    conversion, since opioids do not have complete cross-tolerance. A 33% dose reduction from the
    calculated dose of 100 mg is equal to 67 mg of oral morphine per day.
  6. The recommended dosing frequency of
    long-acting morphine (MS Contin
    ) is every 12 hours (2 doses per
    day).
  7. MS Contin
    is available in 15 mg, 30 mg, 100 mg and 200 mg controlled-release
    tablets. The tablet strength
    closest to the calculated dose is 30 mg. The proper starting dose should
    therefore be 30 mg of sustained-release morphine every 12 hours.

 

 

Guidelines for
Administering Naloxone for Reversal of Opioid-Induced Respiratory Depression

Opioid
overdose:

0.4 mg 0.8 mg IV/IM/SQ,
titrated in accordance with the patients response; repeat as needed. If given IV, each 0.4 mg should be given over
15 seconds.

Opioid-induced
respiratory depression

0.04 mg/ml (40 mcg/ml)
dilution in syringe (mix 0.4 mg/1 ml of naloxone and 9 ml of normal saline in a
syringe for IV administration).

    
Administer
0.5 ml of diluted solution (0.02 mg or 20 mcg) every 2 minutes until a change
in alertness is observed.

    
Titrate
naloxone until patient is responsive or a total of 0.8 mg (20 ml of diluted
solution) has been given. Continue
looking for other causes of sedation and respiratory depression.

    
Discontinue
naloxone when patient is responsive to physical stimulation, respiratory rate
is > 8 breaths per minute, and
able to take deep breaths when told to do so.

 

Special
considerations

May need repeated doses or
continuous infusion. Depending on amount
and type of opioid given and time interval since last opioid administration,
the duration of action of some opioids may exceed that of naloxone.

Titrate dose cautiously to
avoid precipitation of profound withdrawal, seizures, and severe pain.

 

Use of Oral Methadone for Chronic Pain

  1. Opioid-nave patients
    1. Recommended starting
      dose range is 2.5 mg daily to 2.5 mg TID.
    2. For frail and/or
      older patients, the starting dose is 2.5 mg daily.
  1. Patients taking
    opioids
    1. Determine the daily
      oral morphine equivalent dose of current opioids.
    2. Convert daily oral
      morphine equivalent dose (DOMED) to oral methadone.
    3. Methadone dose should be adjusted
      every 5 days due to delayed onset of respiratory depression.

 

Methadone
Conversion Ratios








Current DOMED

Conversion ratio

(morphine : methadone)

Conversion factor

(approximate % of DOMED)

<30 mg

2 : 1

50%

30 99 mg

4 : 1

25%

100 299 mg

8 : 1

12. 5%

300 499 mg

12 : 1

8.3%

500 999 mg

15 : 1

6.6%

> 1,000 mg

20 : 1

5%

Example of conversion to oral methadone:

  1. Patient is taking 80 mg Oxycontin
    orally 3 times daily.
  2. The total daily dose of oxycodone is
    240 mg daily.
  1. The next step is to convert 240 mg of
    oral oxycodone to the daily oral morphine equivalent dose (DOMED).
  2. The equianalgesic chart indicates that
    20 mg of oral oxycodone is equal to 30 mg of oral morphine.

5. The patients current dose of 240 mg per day
of oral oxycodone is equal to 360 mg per day of oral morphine.

  1. The methadone conversion table
    indicates that a conversion factor for a DOMED of 360mg equals 8.3% or a
    12 to 1 ratio of morphine to methadone.
  2. The patients DOMED of 360 mg is equal
    to 30 mg of methadone daily.
  3. The recommended dosing frequency of
    methadone for chronic pain is 1 to 3 times daily, so the proper daily
    methadone dose would be 10 mg three times daily.
  4. May need to use breakthrough medication
    as needed for the first week, while methadone achieves steady-state blood
    levels.

Pain Medicine Service

 

For difficulties
with pain management, contact the Pain Medicine Service at 6-2320 (clinic) or 3832 (on call pager).

 

References:

American Hospital Formulary Service Drug
Information 2005. American Society of
Health-System Pharmacists.

 

American Pain Society (2003). Principles of analgesic use in the treatment
of acute pain and cancer pain
(5th ed.) Glenview, IL: Author.

 

U.S. Department of Health and Human Services. (1992).

Acute pain management: Operative or medical
procedures and trauma

(AHCPR Publication No. 92-0032).
Rockville, MD: Author.

 

VA/DoD Clinical Practice Guideline for the
Management of Opioid Therapy for Chronic Pain.
Department of Veterans Affairs
and Department of Defense. Version
1.0 March 2003.

 

Written
1990

Revised
7/26/1999

Revised 9/2003

Revised
4/2005

 

 

 

5 most addictive substances and their effect on our brain

Health

March 1, 2021

About what some drugs, alcohol and nicotine do to our bodies.

This ranking was compiled by British psychiatrist and professor of neuropsychopharmacology David Nutt and his research team.

1. Heroin

Heroin is an opioid drug that causes severe mental and physical dependence. This is due to the fact that when injected, the substance quickly penetrates the brain, easily overcoming the blood-brain barrier between the circulatory and central nervous systems. In the brain, it causes an increased production of dopamine. Experiments on experimental animals have shown an increase in the level of this pleasure hormone by 200%.

Heroin mimics natural brain chemicals that nature has created to control pain and increase pleasure.

An additional addictive mechanism is increased production of the excitatory neurotransmitter glutamate. Combined with the severe withdrawal symptoms—pain, anxiety, cramps, insomnia—it leads to a severe addiction. Withdrawal begins 4-24 hours after taking the last dose, and the addict is in dire need of another portion of the drug. In addition, the body quickly develops tolerance to heroin – a person needs more and more dose each time.

Heroin addicts often die of heart attacks, strokes, as the drug affects the state of the cardiovascular system. Another cause of death is exhaustion, which leads to constant stimulation of the central nervous system. Experts assigned this drug three points out of three possible according to the degree of dependence formation.

2. Cocaine

Cocaine is an alkaloid found in plants of the genus Erythroxylum. In nature, it acts as an insecticide and protects the leaves of shrubs from being eaten by insects. Cocaine has a powerful stimulating effect on the central nervous system, causing a feeling of euphoria.

Normally, the reward system in the brain works according to certain rules. A neurotransmitter – in this case, dopamine – enters the space between neurons called the synapse. Specialized receptors transmit a signal to respond to its appearance, then remove the neurotransmitter from the synapse to stop its effect.

Cocaine blocks dopamine reuptake systems, causing it to work again and again, leading to a whirlwind of pleasure.

However, cocaine euphoria does not last forever, and after the end of the drug, a phase of depression begins. Other side effects include fatigue, anxiety, and insomnia.

Cocaine is dangerous for the cardiovascular system. It causes powerful spasms that can lead to cerebral hemorrhage, disrupt the heart or other organs. Another negative effect is the state of acute psychosis, in which a person has little control over himself. In addition, there is a myth that cocaine is not addictive, but this is not true.

3. Nicotine

Nicotine, like cocaine, is an alkaloid that naturally performs the function of fighting insects. This is the main component of tobacco, which is addictive. Nicotine is quickly absorbed by the lungs and transported to the brain. It increases the activity of nicotinic acetylcholine receptors, which leads to the release of adrenaline. This temporarily stimulates various systems of the body, and the person feels more alert and active. And the release of dopamine accompanies smoking with a feeling of pleasure.

Nicotine is toxic, long-term use contributes to the development of cancer, ischemia, angina pectoris, and so on. WHO claims that up to 50% of smokers die from smoking-related causes.

4. Barbiturates

Sedatives and hypnotics based on barbituric acid have a depressant effect on the central nervous system. Depending on the dosage, the drugs may have a mild relaxing effect or lead to coma.

Barbiturates stimulate receptors for the inhibitory neurotransmitter gamma-aminobutyric acid, resulting in slower transmission of impulses to the CNS. This leads to muscle relaxation, calming, eliminates anxiety. The problem of drug dependence was hushed up for a long time, but subsequently recognized and abandoned barbiturates in favor of benzodiazepines.

However, if cocaine and heroin are illegal, these drugs have been relatively available for a long time, which increases their danger.

5. Alcohol

Absolutely legal in most countries, alcoholic beverages are named the most dangerous drug in the world. They also become addictive fairly quickly. Animal studies have shown that alcohol increases dopamine levels by 40-360%.

Alcohol enhances the effect of gamma-aminobutyric acid (GABA) – the main inhibitory mediator of the nervous system. Therefore, the movements and speech of drunk people slow down, and a dose of alcohol relaxes. GABA gradually adapts to changes, reducing the activity of the corresponding receptors, which makes the brain dependent on alcohol.

If a person stops drinking alcohol, reduced activity of GABA receptors leads to a weakening of the nervous inhibition function, and the brain becomes more excitable.

At the same time, ethanol reduces the ability of another neurotransmitter, glutamate, to act on NMDA receptors. With long-term use of alcohol, the number of these receptors increases. The brain becomes less receptive to alcohol and more receptive to glutamate. This increases excitability, leading to withdrawal symptoms: seizures, anxiety.

Another reason for the formation of addiction is the ability to quickly get energy to feed the brain. This requires acetate, an intermediate product of ethanol metabolism. The brain sits down on a simple source of energy. In the body of a regular drinking person, alcohol replaces the usual source of energy – glucose.

According to the World Health Organization, 3.3 million people die every year due to alcohol consumption. The statistics include diseases and injuries associated with drunkenness.


Dr. Nutt himself noted that the legal status of a drug is not necessarily associated with dependence or harm from it. Tobacco and alcohol occupy high positions in the ranking, but remain legal.

However, the existence of this list does not mean at all that substances that are not included in it do not cause addiction. Therefore, the rating should not be taken as a tool for dividing drugs into harmful and harmless. The use of any psychoactive substance has consequences.

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