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Nystatin over the counter for babies. Nystatin for Babies: Treating Yeast Rashes in Infants Effectively

What is nystatin and how does it treat yeast rashes in babies. How to apply nystatin cream, ointment, or powder for infants. What are the potential side effects of nystatin in babies. When should parents consult a doctor about yeast infections in infants.

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Understanding Nystatin and Its Use in Treating Infant Yeast Infections

Nystatin is an antifungal medication commonly used to treat yeast infections in babies. These infections, often referred to as diaper rash or thrush, can cause discomfort and irritation for infants. Nystatin works by targeting and eliminating the fungus responsible for these infections, providing relief and promoting healing.

Is nystatin available over the counter for babies? Typically, nystatin requires a prescription from a healthcare provider. However, some countries may offer certain formulations without a prescription. It’s crucial to consult with a pediatrician before using any medication on an infant.

Types of Nystatin Formulations for Infants

  • Cream
  • Ointment
  • Powder

Each formulation has its specific application method, which we’ll discuss in detail later in this article.

Identifying Yeast Rashes in Babies: Signs and Symptoms

Recognizing a yeast rash in infants is crucial for prompt treatment. These rashes often appear in warm, moist areas of the body, such as the diaper area or skin folds. Can you differentiate between a regular diaper rash and a yeast infection? Here are some key signs to look out for:

  • Bright red, slightly raised patches
  • Satellite lesions (smaller spots surrounding the main rash)
  • Persistent despite regular diaper changes and barrier creams
  • May be accompanied by oral thrush (white patches in the mouth)

If you notice these symptoms, it’s advisable to consult your pediatrician for proper diagnosis and treatment recommendations.

Proper Application of Nystatin for Optimal Results

Applying nystatin correctly is essential for effective treatment of yeast infections in babies. The application method varies slightly depending on the formulation used:

Nystatin Cream and Ointment Application

  1. Wash your hands thoroughly before and after application.
  2. Clean the affected area gently and pat dry.
  3. Apply a thin layer of cream or ointment to the affected skin.
  4. Gently massage the medication into the skin.
  5. Repeat as directed by your healthcare provider, typically 2-4 times daily.

Nystatin Powder Application

  1. Ensure the affected area is clean and dry.
  2. Sprinkle a thin layer of powder over the affected skin.
  3. For athlete’s foot, you may also sprinkle the powder in your baby’s shoes and socks.

How long should you continue applying nystatin? Treatment duration varies, but typically lasts 7-14 days. Always follow your pediatrician’s instructions and complete the full course of treatment, even if symptoms improve earlier.

Potential Side Effects and Precautions When Using Nystatin on Infants

While nystatin is generally considered safe for use in infants, it’s important to be aware of potential side effects and take necessary precautions:

Common Side Effects

  • Mild skin irritation
  • Itching
  • Burning sensation

Rare but Serious Side Effects

  • Severe allergic reactions (rash, hives, difficulty breathing)
  • Persistent irritation or worsening of symptoms

When should you contact your pediatrician about side effects? If you notice any severe reactions or if the rash doesn’t improve after several days of treatment, consult your healthcare provider immediately.

Preventing Recurrent Yeast Infections in Babies

While treating current infections is important, preventing future occurrences is equally crucial. Here are some strategies to minimize the risk of recurrent yeast infections in infants:

  • Change diapers frequently to keep the area dry
  • Allow some diaper-free time to air out the skin
  • Use gentle, fragrance-free wipes or warm water for cleaning
  • Apply a barrier cream with zinc oxide during diaper changes
  • Avoid tight-fitting clothing that may trap moisture
  • If breastfeeding, treat any nipple thrush to prevent reinfection

How can you incorporate these preventive measures into your daily routine? Consider setting reminders for diaper changes and allocating specific times for diaper-free play.

Alternative Treatments for Yeast Infections in Infants

While nystatin is a common and effective treatment, there are alternative options available for treating yeast infections in babies. These may be considered in cases of nystatin allergies or as complementary treatments:

  • Miconazole cream
  • Clotrimazole cream
  • Natural remedies (e.g., coconut oil, apple cider vinegar baths)

Are natural remedies as effective as prescription antifungals? While some natural treatments may provide relief, their efficacy is often not as well-studied as prescription medications. Always consult with your pediatrician before trying alternative treatments.

When to Seek Medical Attention for Persistent Yeast Infections

In most cases, yeast infections in babies respond well to treatment with nystatin or other antifungal medications. However, there are situations where additional medical attention may be necessary:

  • Symptoms persist after a full course of treatment
  • The rash spreads or worsens despite treatment
  • Your baby develops a fever or seems unusually fussy
  • You notice signs of a secondary bacterial infection (increased redness, swelling, or pus)

How quickly should you expect to see improvement with nystatin treatment? Most parents notice some improvement within 2-3 days of starting treatment. If you don’t see any changes after 3-4 days, it’s advisable to contact your pediatrician.

Understanding the Relationship Between Antibiotics and Yeast Infections in Infants

Antibiotics can sometimes lead to an increased risk of yeast infections in babies. This occurs because antibiotics can disrupt the natural balance of bacteria and fungi in the body, allowing yeast to overgrow. If your baby has recently been on antibiotics and develops a yeast infection, it’s important to inform your pediatrician.

Can probiotics help prevent antibiotic-associated yeast infections? Some studies suggest that probiotics may help maintain a healthy balance of microorganisms in the body. However, always consult with your pediatrician before giving any supplements to your infant.

Strategies to Minimize Yeast Overgrowth During Antibiotic Treatment

  • Keep the diaper area clean and dry
  • Consider using a barrier cream with each diaper change
  • Ask your pediatrician about probiotic supplementation
  • Be vigilant for signs of yeast overgrowth and report them promptly

The Impact of Diet on Yeast Infections in Infants

While diet plays a more significant role in yeast infections for older children and adults, it can still be a factor for infants, particularly those who are breastfed or starting solid foods.

For Breastfed Babies

A mother’s diet can potentially influence the likelihood of yeast infections in breastfed infants. Some dietary considerations include:

  • Reducing sugar intake, as yeast thrives on sugar
  • Limiting refined carbohydrates
  • Incorporating probiotic-rich foods like yogurt
  • Ensuring adequate intake of vitamins and minerals to support immune function

For Babies Starting Solids

As babies begin to explore solid foods, certain dietary choices may impact their susceptibility to yeast infections:

  • Introduce new foods gradually to monitor for any reactions
  • Limit sugary foods and juices
  • Offer a variety of fruits, vegetables, and whole grains
  • Consider probiotic-rich foods suitable for infants (consult with your pediatrician first)

How can parents balance nutritional needs with yeast infection prevention? Focus on offering a diverse, nutrient-rich diet while being mindful of excessive sugar intake. Always consult with your pediatrician or a registered dietitian for personalized advice.

The Role of Environmental Factors in Infant Yeast Infections

Environmental conditions can significantly influence the development and persistence of yeast infections in babies. Understanding these factors can help parents create a less hospitable environment for yeast growth:

Temperature and Humidity

Yeast thrives in warm, moist environments. To minimize risk:

  • Keep the nursery at a comfortable, cool temperature
  • Use a dehumidifier if you live in a humid climate
  • Ensure good air circulation in the baby’s room

Clothing and Diaper Choices

The right choices in clothing and diapers can make a big difference:

  • Opt for breathable, natural fabrics like cotton
  • Avoid tight-fitting clothes, especially in warm weather
  • Choose diapers with good absorbency and consider cloth diapers
  • Change wet or soiled diapers promptly

Bathing and Hygiene Practices

Proper hygiene is crucial in preventing yeast infections:

  • Use mild, fragrance-free soaps for bathing
  • Avoid prolonged baths; opt for quick, thorough cleaning
  • Pat the skin dry gently, paying special attention to skin folds
  • Consider using a hair dryer on a cool setting to ensure complete drying

How often should you bathe your baby to prevent yeast infections? While daily baths aren’t necessary, keeping your baby clean and dry is key. A gentle cleanse during diaper changes and a bath every few days is typically sufficient.

Long-Term Management of Recurrent Yeast Infections in Infants

Some babies may be prone to recurrent yeast infections. In these cases, a long-term management strategy may be necessary:

Maintenance Therapy

Your pediatrician might recommend a maintenance approach:

  • Regular use of antifungal creams, even when symptoms are not present
  • Periodic use of nystatin or other antifungals to prevent outbreaks
  • Incorporating probiotics into the baby’s routine (under medical supervision)

Identifying and Addressing Underlying Causes

Persistent yeast infections may indicate other health issues:

  • Immune system concerns
  • Allergies or sensitivities
  • Hormonal imbalances

Working closely with your pediatrician can help identify and address any underlying factors contributing to recurrent infections.

Lifestyle Adjustments

Long-term management often involves ongoing lifestyle modifications:

  • Maintaining a consistent diaper change routine
  • Regularly sanitizing toys and other items that come into contact with the baby
  • Educating caregivers about prevention strategies
  • Considering dietary adjustments for breastfeeding mothers or babies on solids

How can parents stay vigilant without becoming overly anxious about recurrent infections? Establish a routine for skin checks and hygiene practices, but try to maintain a balanced perspective. Remember that many babies outgrow their susceptibility to yeast infections as their immune systems develop.

The Psychological Impact of Persistent Yeast Infections on Parents and Infants

Dealing with recurrent yeast infections in babies can take an emotional toll on both parents and infants. It’s important to address these psychological aspects:

For Parents

  • Feelings of frustration or inadequacy
  • Anxiety about the baby’s comfort and health
  • Stress from constant vigilance and care routines
  • Potential strain on relationships due to added responsibilities

For Infants

  • Discomfort and irritability
  • Potential sleep disruptions
  • Possible impact on bonding due to discomfort during diaper changes or feeding

How can parents manage their stress while caring for a baby with recurrent yeast infections? Self-care is crucial. Consider joining support groups, seeking counseling if needed, and ensuring you have a support system to share the care responsibilities.

Strategies for Coping

  • Practice stress-reduction techniques like deep breathing or meditation
  • Seek support from family, friends, or parent groups
  • Maintain open communication with your pediatrician
  • Focus on positive bonding activities with your baby
  • Celebrate small victories in managing the condition

Remember, persistent health issues in infants can be challenging, but they are often temporary. With proper care and support, most babies overcome these challenges, and families emerge stronger.

Future Developments in Treating Infant Yeast Infections

As medical research continues to advance, new approaches to treating and preventing yeast infections in infants are emerging:

Innovative Treatments

  • Development of new antifungal medications with fewer side effects
  • Research into probiotic strains specifically targeting yeast overgrowth
  • Exploration of natural compounds with antifungal properties

Advanced Diagnostic Tools

Improved methods for quickly and accurately diagnosing yeast infections in infants are being developed, potentially leading to faster and more targeted treatments.

Personalized Medicine Approaches

Future treatments may be tailored to an individual baby’s microbiome and genetic profile, offering more effective and personalized care.

What can parents expect in terms of future treatments for infant yeast infections? While current treatments like nystatin remain effective, ongoing research promises more options and potentially more efficient treatments in the coming years. Stay informed by discussing the latest developments with your pediatrician during check-ups.

As we continue to learn more about the delicate balance of microorganisms in infants’ bodies, our approach to treating and preventing yeast infections will likely become more sophisticated and effective. This ongoing research offers hope for easier management and better outcomes for babies prone to these infections.

Nystatin (Topical: Pediatric Medication | Memorial Sloan Kettering Cancer Center

Pediatric Medication

This information from Lexicomp® explains what you need to know about this medication, including what it’s used for, how to take it, its side effects, and when to call your healthcare provider.

Brand Names: US

Nyamyc; Nystop

What is this drug used for?

  • It is used to treat fungal infections of the skin.

What do I need to tell the doctor BEFORE my child takes this drug?

  • If your child is allergic to this drug; any part of this drug; or any other drugs, foods, or substances. Tell the doctor about the allergy and what signs your child had.

This drug may interact with other drugs or health problems.

Tell the doctor and pharmacist about all of your child’s drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe to give this drug with all of your child’s other drugs and health problems. Do not start, stop, or change the dose of any drug your child takes without checking with the doctor.

What are some things I need to know or do while my child takes this drug?

  • Tell all of your child’s health care providers that your child is taking this drug. This includes your child’s doctors, nurses, pharmacists, and dentists.
If your child is pregnant or breast-feeding a baby:
  • Talk with the doctor if your child is pregnant, becomes pregnant, or is breast-feeding a baby. You will need to talk about the benefits and risks to your child and the baby.

What are some side effects that I need to call my child’s doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your child’s doctor or get medical help right away if your child has any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Irritation where this drug was used.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your child’s doctor or get medical help if your child has any side effects that bother your child or do not go away.

These are not all of the side effects that may occur. If you have questions about side effects, call your child’s doctor. Call your child’s doctor for medical advice about side effects.

You may report side effects to your national health agency.

How is this drug best given?

Give this drug as ordered by your child’s doctor. Read all information given to you. Follow all instructions closely.

All products:
  • Use as you have been told, even if your child’s signs get better.
  • Do not give by mouth. Use on your child’s skin only. Keep out of your child’s mouth, nose, and eyes (may burn).
  • Wash your hands before and after use.
  • Clean affected part before use. Make sure to dry well.
Cream, ointment:
  • Put a thin layer on the affected part and rub in gently.
Powder:
  • Sprinkle powder over affected skin.
  • If this drug is for athlete’s foot, you may sprinkle in your child’s shoes and socks.

What do I do if my child misses a dose?

  • Put on a missed dose as soon as you think about it.
  • If it is close to the time for your child’s next dose, skip the missed dose and go back to your child’s normal time.
  • Do not put on 2 doses at the same time or extra doses.

How do I store and/or throw out this drug?

  • Store at room temperature. Do not freeze.
  • Keep lid tightly closed.
  • Protect from heat.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

General drug facts

  • If your child’s symptoms or health problems do not get better or if they become worse, call your child’s doctor.
  • Do not share your child’s drug with others and do not give anyone else’s drug to your child.
  • Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your child’s doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Consumer Information Use and Disclaimer

This generalized information is a limited summary of diagnosis, treatment, and/or medication information. It is not meant to be comprehensive and should be used as a tool to help the user understand and/or assess potential diagnostic and treatment options. It does NOT include all information about conditions, treatments, medications, side effects, or risks that may apply to a specific patient. It is not intended to be medical advice or a substitute for the medical advice, diagnosis, or treatment of a health care provider based on the health care provider’s examination and assessment of a patient’s specific and unique circumstances. Patients must speak with a health care provider for complete information about their health, medical questions, and treatment options, including any risks or benefits regarding use of medications. This information does not endorse any treatments or medications as safe, effective, or approved for treating a specific patient. UpToDate, Inc. and its affiliates disclaim any warranty or liability relating to this information or the use thereof. The use of this information is governed by the Terms of Use, available at https://www.wolterskluwer.com/en/know/clinical-effectiveness-terms.

Last Reviewed Date

2020-08-27

Copyright

© 2023 UpToDate, Inc. and its affiliates and/or licensors. All rights reserved.

Last Updated

Monday, December 12, 2022

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What is thrush?

Thrush is a fungal infection caused by a yeast called candida. In babies, thrush often occurs in areas where the lining of the mouth is cracking and moist. Many babies get thrush in the mouth in the first few weeks or months of life. If your child has thrush, he or she will have:

  • White, irregularly shaped patches coat the inside of the lips and cheeks and sometimes the tongue. (If the only symptom is a uniformly white tongue, it’s due to a milk diet, not thrush.) 
  • White coating that sticks to the mouth and cannot be washed away or wiped off.

Thrush causes mild mouth discomfort.

What is the cause?

Most people already have candida in their mouth and other parts of their bodies. Sometimes certain conditions, such as use of an antibiotic or too much moisture can cause the yeast to grow rapidly and cause thrush. In babies, thrush often occurs in areas where the lining of the mouth is cracking and moist from too much sucking (as when a baby sleeps with a bottle or pacifier). A large pacifier or nipple can more easily injure the lining of the mouth. Thrush is generally not spread to others under normal conditions. However, if you are breast-feeding and your baby has thrush, the yeast could flare up and cause thrush on your breasts.

How can I take care of my child?

  • Nystatin oral medicine 

    The drug for clearing this up is nystatin oral suspension. It requires a prescription.

    Give 1 ml of nystatin 4 times a day after meals or at least 30 minutes before you feed your baby. Place the nystatin in the front of the mouth on each side. It doesn’t do any good once it’s swallowed. If the patches of thrush in the mouth don’t start improving in 2 days, rub the nystatin directly on the patches. Use a cotton swab or a gauze wrapped on your finger. Keep this up for at least 7 days, or until all the thrush has been gone for 3 days.


    If you are breast-feeding, apply nystatin to any irritated areas on your nipples.

  • Decrease sucking time during feeding 

    If sucking on a nipple is painful for your child, temporarily use a cup and spoon. In any case, while your child has thrush, reduce sucking time to 20 minutes or less per feeding.


    If the thrush comes back after treatment and your child is bottle-fed, switch to a nipple with a different shape and made from silicone.

  • Restrict pacifier use 

    While your child has thrush don’t give him a pacifier, except when it’s really needed to calm your baby. If your infant is using an orthodontic-type pacifier, switch to a smaller, regular one. Special washing of bottle nipples or pacifiers is not necessary or helpful.

     
  • Diaper rash associated with thrush 

    If your child has a diaper rash as well as thrush, assume the rash is caused by yeast. Buy Lotrimin cream at your local pharmacy and put it on your baby’s bottom 4 times a day.

Call 911

If you feel that your child needs immediate medical care.


Call us during office hours if:

  • Your child refuses to drink. 
  • The thrush gets worse during treatment. 
  • The thrush lasts beyond 10 days despite treatment. 
  • You have other concerns or questions.

Written by B.D. Schmitt, MD, author of “Your Child’s Health,” Bantam Books.
This content is reviewed periodically and is subject to change as new health information becomes available. The information is intended to inform and educate and is not a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional.

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Nystatin instructions for use, price: What helps, contraindications

THERE ARE CONTRAINDICATIONS. POSSIBLE SIDE EFFECTS. A SPECIALIST’S CONSULTATION IS REQUIRED.

  • Is nystatin an antibiotic or not?
  • Nystatin: what are the tablets for
  • Nystatin for stomatitis
  • Nystatin during pregnancy
  • Nystatin or fluconazole: which is better?
  • Nystatin or Levorin: which is better
  • Nystatin or Pimafucin: which is better?
  • Summary
  • Ask an expert about the topic of the article
  • About 75% of women have experienced thrush at least once in their lives. In 10-20% of cases, there are no symptoms. However, most patients develop curdled discharge and severe itching in the vulva.

    Pharmacist Evgenia Pogorelova talks about Nystatin, which is used to treat thrush. From the article you will learn: does the drug belong to antibiotics, about its indications, use during pregnancy and differences from analogues.

    All products Nystatin

    20 reviews

    Nystatin – is it an antibiotic or not?

    Nystatin is an antifungal drug. According to some classifications for specialists, it also belongs to antibiotics, as it inhibits the vital activity of microorganisms related to fungi.

    The drug is produced in several dosage forms:

    • Nystatin tablets
    • Nystatin vaginal suppositories
    • Nystatin rectal suppositories
    • Nystatin ointment

    Nystatin: what

    tablets are for Nystatin tablets are used to treat infections caused by Candida genus . They are called candidiasis. The drug causes the death of microorganisms, so the symptoms caused by the infection go away.

    Nystatin tablets: what helps

    The drug helps to treat candidiasis of the gastrointestinal tract. In addition, tablets are used before and after operations performed on the digestive organs. This helps prevent infection.

    Nystatin – tablets for thrush, but more often vaginal suppositories are used to treat it. Nystatin for cystitis is not used if it is not caused by a fungus of the genus Candida . Most often the disease is caused by a bacterium E. coli.

    Nystatin for stomatitis

    Thrush is not just a vaginal infection. It can also affect the lining of the mouth. It belongs to the organs of the gastrointestinal tract, so nystatin for the oral cavity is used in the form of tablets.

    Nystatin during pregnancy

    Tablets are administered with caution under the supervision of a physician in any trimester. Nystatin vaginal suppositories and rectal suppositories are contraindicated during pregnancy. But their use is possible during breastfeeding, since the drug in the form of suppositories is not excreted in breast milk.

    Nystatin ointment is used during pregnancy only on the advice of a doctor. During lactation, you can use it, excluding the application to the area of ​​\u200b\u200bthe mammary glands and after consulting a doctor.

    Nystatin or fluconazole: which is better?

    The drugs have different active ingredients, but they are successfully used for candidiasis. Nystatin from vaginal thrush in the form of suppositories is inconvenient to use: they need to be administered 2 times a day for 10-14 days. At the same time, it is often enough to take 1 capsule of Fluconazole to get rid of the disease.

    Fluconazole has more indications for use. He, unlike Nystatin, fights not only with Candida fungi, but also with other species. Nystatin tablets can be given to children from the age of 13, and Fluconazole capsules – from 3. Both drugs are available by prescription, so what is best for each individual patient must be decided by the doctor.

    Nystatin or Levorin: which is better

    Levorin has a slightly wider spectrum of action than Nystatin. It also acts on the cause of candidiasis, as well as amoeba, Trichomonas and Leishmania. Levorin, unlike Nystatin, is available only in the form of tablets and ointments. When treating genital candidiasis in women, it is better to choose Nystatin suppositories to reduce the risk of side effects from Levorin tablets.

    Levorin tablets are approved for use in children from 2 years of age. If you need to use the medicine in children under 2 years old, you need to consult a doctor. Thus, for children under 13 years old, it is better to choose Levorin.

    Nystatin or Pimafucin: which is better?

    Pimafucin is an antifungal agent based on natamycin. It is effective against fungi of the genus Candida , like Nystatin, as well as other types of fungi. The drug in the form of candles is safe for pregnant women. For this category of patients, it is better to use Pimafucin.

    All products Pimafucin

    20 reviews

    All products Fluconazole

    21 reviews

    Summary

    • Nystatin is an antibiotic with antifungal activity.
    • Nystatin tablets are used to treat infections caused by the fungus Candida .
    • The drug can be used for stomatitis caused by a fungus.
    • Nystatin is either contraindicated during pregnancy or used only on prescription. It depends on the form of release of the drug.
    • For children under 13 years of age, Fluconazole or Levorin is better than Nystatin.
    • Pimafucin, unlike Nystatin, is allowed for pregnant women.

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    Nystatin instructions for use: indications, contraindications, side effects – description Nystatin suppositories rect. 500 thousand units: 10 pcs. (3689)

    📜 Instructions for use Nystatin

    💊 Composition of the drug Nystatin

    ✅ Use of the drug Nystatin

    📅 Storage conditions Nystatin

    ⏳ Expiration date Nystatin

    Save

    Search for analogues

    Product description

    Nystatin
    (Nystatin)

    Based on prescribing information and approved by the manufacturer
    and prepared for the electronic edition of Vidal 2005
    year, update date: 2021. 02.11

    Marketing authorization holder:

    BIOSINTEZ, PAO
    (Russia)

    Group:

    BIOTEK MFPDC, CJSC

    (Russia)

    Contacts for inquiries:

    BIOSINTEZ OJSC
    (Russia)

    ATX code:

    A07AA02

    (Nystatin)

    Active substance:
    nystatin
    (nystatin)

    Rec.INN

    registered by WHO

    Dosage forms

    Nystatin

    Ointment 100 thousand units/1 g: tubes 30 g

    reg. No.: LSR-008634/08
    dated 30.10.08
    – Indefinitely

    Supp. vaginal 250 thousand units: 10 pcs.

    reg. No.: P N000840/02
    from 28.04.08
    – Indefinitely

    Re-registration date: 04/12/19

    Supp. rectal 250 thousand units: 10 pcs.

    reg. No.: P N000840/01
    from 24.04.08
    – Indefinitely

    Re-registration date: 08/02/19

    Supp. rectal 500 thousand units: 10 pcs.

    reg. No.: P N000840/01
    from 24.04.08
    – Indefinitely

    Re-registration date: 08/02/19

    Supp. vaginal 500 thousand units: 10 pcs.

    reg. No.: P N000840/02
    from 28.04.08
    – Indefinitely

    Re-registration date: 04/12/19

    Tab., coated film casing, 250 thousand units: 10 or 20 pcs.

    reg. No.: P N000840/03
    dated 07.05.13
    – Indefinitely

    Tab. , coated film casing, 500 thousand units: 10 or 20 pcs.

    reg. No.: R N000840/03
    dated 07.05.13
    – Indefinitely

    Release form, packaging and composition
    drug Nystatin

    Film-coated tablets light yellow with a greenish tinge, with a slight odor of vanillin; two layers are visible in cross section.

    Excipients : lactose, basic magnesium carbonate, OPMC, calcium stearate, potato starch, MC-16, titanium dioxide pigment, tween-80, tropeolin O, vaseline oil, vanillin.

    10 pcs. – packings are cell planimetric.
    20 pcs. – glass jars.
    20 pcs. – polymer cans (1) – packs of cardboard.

    Ointment yellow or brownish yellow.

    Excipients : anhydrous lanolin, medical vaseline.

    30 g – aluminum tubes.

    Vaginal suppositories yellow, torpedo-shaped.

    Excipients : P-hydroxybenzoic acid propyl ester, food grade citric acid, witepsol H-15, witepsol W-35.

    5 pcs. – cellular contour packings (2) – packs of cardboard.

    Rectal suppositories yellow, torpedo-shaped.

    Excipients : parahydroxybenzoic acid propyl ester, edible citric acid, vaseline oil, Witepsol H-15, Witepsol W-35.

    5 pcs. – cellular contour packings (2) – packs of cardboard.

    Clinical and pharmacological group:

    Antifungal drug for topical use

    Pharmacotherapeutic group:

    Antifungal agent

    Pharmacological action

    Antifungal drug from the group of polyenes. By binding to sterols in the cell membrane of fungi, it disrupts its permeability, which leads to the release of the main components of the cell. It has a fungistatic effect.

    Active against yeast-like fungi of the genus Candida.

    Pharmacokinetics

    Absorption and distribution

    After oral administration, nystatin is poorly absorbed from the gastrointestinal tract. When applied topically, it is not absorbed into the systemic circulation. Does not accumulate.

    Elimination

    Excreted from the body with feces.

    Indications of the drug

    Nystatin

    For tablets and ointments

    • candidiasis of the skin and mucous membranes;
    • candidiasis of internal organs;
    • prevention of candidiasis during long-term antimicrobial therapy, especially in malnourished and debilitated patients.

    For vaginal suppositories

    • vaginal candidiasis;
    • prevention of fungal complications during local antimicrobial therapy.

    For rectal suppositories

    • lower intestinal candidiasis;
    • prevention of fungal infections in the pre- and postoperative periods.

    Open list of ICD-10 codes

    B37.0 Candidal stomatitis
    B37.2 Skin and nail candidiasis
    B37.3 Vulvar and vaginal candidiasis
    B37.4 Candidiasis of other urogenital sites
    B37.8 Candidiasis of other localizations (including candidiasis enteritis)
    N77.1 Vaginitis, vulvitis and vulvovaginitis in infectious and parasitic diseases classified elsewhere
    Z29. 8 Other specified preventive measures

    Dosage regimen

    When treatment of candidiasis of internal organs Nystatin is administered orally, regardless of food intake.

    Adults are prescribed 500,000 IU 4-8 times / day.

    In case of generalized candidiasis appoint up to 6,000,000 IU/day.

    Children aged 1-3 years are prescribed 250,000 IU 3-4 times / day, over the age of 3 years – 250,000-500,000 IU 4 times / day. The duration of treatment is 10-14 days. If necessary, the course of treatment is repeated after a week.

    When treatment of candidiasis of the skin and mucous membranes ointment is applied in a thin layer to the affected areas 2 times a day, daily for 7-10 days. The use of the ointment can be combined with the intake of Nystatin inside.

    Vaginal suppositories are inserted into the vagina after hygiene procedures, 1 suppository 2 times a day (morning and evening). The course of treatment is 10-14 days.

    Rectal suppositories are injected deep into the rectum, 1 suppository 2 times a day (morning and evening). The course of treatment is 10-14 days.

    If necessary, repeat courses of treatment.

    Side effects

    On the part of the digestive system: when taking the drug orally and using rectal suppositories, nausea, vomiting, diarrhea are possible.

    Allergic reactions: pruritus, chills, fever.

    Other: possible risk of spread of resistant forms of fungi, which requires discontinuation of the drug.

    Contraindications for use

    • abnormal liver function;
    • pancreatitis;
    • peptic ulcer of the stomach and duodenum;
    • pregnancy;
    • hypersensitivity to the components of the drug.

    Use in pregnancy and lactation

    Nystatin is contraindicated for use in pregnancy.

    Use in hepatic impairment

    Contraindicated in hepatic impairment.

    Use in children

    Children aged 1-3 years are prescribed 250,000 IU 3-4 times / day, over the age of 3 years – 250,000-500,000 IU 4 times / day. The duration of treatment is 10-14 days. If necessary, the course of treatment is repeated after a week.

    Special instructions

    If adverse reactions develop, reduce the dose or discontinue the drug.

    During menstruation, do not interrupt the treatment with vaginal suppositories. In fungal diseases of the vagina, simultaneous treatment of the sexual partner is recommended. During the period of treatment, sexual intercourse should be avoided.

    Overdose

    No cases of Nystatin overdose have been reported to date.

    Drug interaction

    With the simultaneous use of nystatin and clotrimazole, the activity of the latter is reduced.

    Storage conditions of the drug Nystatin

    List B. The drug in the form of tablets should be stored in a dry, dark place at a temperature of 18°-20°C.

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