What are the uses of One-A-Day Women’s Formula Oral. How should it be taken. What are the potential side effects. When should you consult a doctor. What precautions should be considered before use.

Understanding One-A-Day Women’s Formula Oral

One-A-Day Women’s Formula Oral is a multivitamin and iron supplement designed to address vitamin deficiencies in women. This product serves as a crucial tool in maintaining overall health and well-being, particularly for those with poor diets, certain illnesses, or during pregnancy.

Key Components and Their Functions

The supplement comprises various vitamins and minerals essential for women’s health. These include:

• Iron: Crucial for blood health and oxygen transport
• Folic Acid: Important for cell growth and fetal development
• Calcium: Essential for bone health
• Vitamin D: Aids calcium absorption and supports immune function
• B-complex vitamins: Support energy metabolism and nervous system function

Proper Usage and Administration

To maximize the benefits of One-A-Day Women’s Formula Oral, it’s essential to follow the recommended dosage and administration guidelines.

Dosage Instructions

How should you take One-A-Day Women’s Formula Oral? The typical dosage is one tablet daily, preferably on an empty stomach. It’s best taken one hour before or two hours after meals with a full glass of water (8 ounces or 240 milliliters). However, if stomach upset occurs, you may take it with food.

Timing Considerations

Are there specific timing considerations for taking this supplement? Indeed, there are. Avoid taking antacids, dairy products, tea, or coffee within 2 hours before or after this medication, as they may decrease its effectiveness. Additionally, it’s advisable not to lie down for at least 10 minutes after taking the tablets or capsules.

Potential Side Effects and Management

While One-A-Day Women’s Formula Oral is generally well-tolerated, some users may experience side effects. Understanding these potential reactions can help in managing them effectively.

Common Side Effects

What are the most common side effects of One-A-Day Women’s Formula Oral? Users may experience:

• Constipation
• Diarrhea
• Upset stomach

These effects are usually temporary and often subside as the body adjusts to the supplement. If these symptoms persist or worsen, it’s advisable to consult a healthcare professional.

Serious Side Effects

While rare, serious side effects can occur. These may include:

• Severe allergic reactions (rash, itching/swelling, severe dizziness, trouble breathing)
• Signs of iron overdose (severe stomach pain, vomiting blood, black stools)

If you experience any of these symptoms, seek immediate medical attention.

Precautions and Contraindications

Before starting One-A-Day Women’s Formula Oral, it’s crucial to consider certain precautions and potential contraindications.

Medical History Considerations

What medical conditions might affect the use of this supplement? Inform your healthcare provider if you have a history of:

• Iron overload disorders (hemochromatosis, hemosiderosis)
• Liver problems
• Stomach/intestinal issues (ulcers, colitis)
• Alcohol use/abuse

Allergies and Interactions

Are there potential allergic reactions or interactions to be aware of? Yes, some formulations may contain soy or other allergens. Additionally, if the supplement contains folic acid, it’s important to disclose any history of vitamin B12 deficiency to your healthcare provider.

Special Considerations for Pregnant Women

One-A-Day Women’s Formula Oral can be particularly beneficial during pregnancy, but special considerations apply.

Benefits During Pregnancy

How does this supplement support pregnant women? It provides essential nutrients crucial for fetal development, including:

• Folic acid for neural tube development
• Iron for increased blood volume
• Calcium for fetal bone development

Precautions During Pregnancy

What precautions should pregnant women take when using this supplement? Always consult with your obstetrician before starting any new supplement regimen during pregnancy. They can provide personalized advice based on your specific health needs and potential risks.

Interactions with Other Medications and Substances

Understanding potential interactions is crucial for safe and effective use of One-A-Day Women’s Formula Oral.

Drug Interactions

Which medications might interact with this supplement? Potential interactions include:

• Antibiotics (tetracyclines, quinolones)
• Thyroid medications
• Bisphosphonates (used for osteoporosis)

Always inform your healthcare provider about all medications and supplements you’re taking.

Food and Beverage Interactions

Are there any food or beverage interactions to be aware of? Yes, calcium-rich foods, caffeine, and tannins (found in tea) can interfere with iron absorption. It’s best to take the supplement at least two hours apart from these substances.

Storage and Safety Precautions

Proper storage and handling of One-A-Day Women’s Formula Oral are essential for maintaining its efficacy and preventing accidental misuse.

Storage Guidelines

How should you store this supplement? Keep it in a cool, dry place away from direct sunlight. Ensure the container is tightly closed and out of reach of children.

Child Safety Measures

Why is child safety particularly important with this product? Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6 years old. Always keep the supplement in a secure location and use child-resistant packaging.

When to Seek Medical Attention

Recognizing when to consult a healthcare professional is crucial for safe use of One-A-Day Women’s Formula Oral.

Signs of Overdose

What are the signs of potential overdose? Symptoms may include:

• Severe stomach pain
• Vomiting blood
• Black, tarry stools
• Metallic taste in the mouth

If you suspect an overdose, seek immediate medical attention or contact a poison control center.

Persistent Side Effects

When should you consult a doctor about side effects? If you experience persistent or worsening side effects, or if you notice any unusual symptoms, contact your healthcare provider promptly.

One-A-Day Women’s Formula Oral can be a valuable addition to a woman’s health regimen when used correctly. By understanding its proper use, potential side effects, and necessary precautions, you can maximize its benefits while minimizing risks. Always consult with a healthcare professional before starting any new supplement regimen, especially if you have pre-existing health conditions or are pregnant.

Remember, while supplements can support overall health, they are not a substitute for a balanced diet and healthy lifestyle. Incorporate One-A-Day Women’s Formula Oral as part of a comprehensive approach to women’s health, including regular exercise, a nutrient-rich diet, and routine health check-ups.

As research in nutrition and women’s health continues to evolve, stay informed about the latest recommendations and guidelines. Your healthcare provider can offer personalized advice based on your individual health needs and help you determine if One-A-Day Women’s Formula Oral is the right choice for you.

By staying informed and proactive about your health, you can make the most of supplements like One-A-Day Women’s Formula Oral and work towards achieving optimal well-being at every stage of life.

One-A-Day Womens Formula Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Warnings:

Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children younger than 6 years. Keep this product out of reach of children. If overdose does occur, get medical help right away or call a poison control center.

Warnings:

Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children younger than 6 years. Keep this product out of reach of children. If overdose does occur, get medical help right away or call a poison control center.

… Show More

Uses

This medication is a multivitamin and iron product used to treat or prevent vitamin deficiency due to poor diet, certain illnesses, or during pregnancy. Vitamins and iron are important building blocks of the body and help keep you in good health.

How to use One-A-Day WOMEN’s

Take this medication by mouth, usually once daily or as directed. Follow all directions on the product package, or take as directed by your doctor. Do not take more than the recommended dosage. If you have any questions, ask your doctor or pharmacist.

This medication is best taken on an empty stomach 1 hour before or 2 hours after meals. Take with a full glass of water (8 ounces or 240 milliliters) unless your doctor directs you otherwise. If stomach upset occurs, you may take this medication with food. Avoid taking antacids, dairy products, tea, or coffee within 2 hours before or after this medication because they may decrease its effectiveness. Do not lie down for at least 10 minutes after taking the tablets or capsules. Consult your doctor or pharmacist for details for your particular brand.

If you are taking the delayed-release form or extended-release capsules, swallow them whole. Do not crush or chew delayed-release or extended-release products. Doing so can release all of the drug at once, increasing the risk of side effects and decreasing absorption. Also, do not split extended-release tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.

Take this medication regularly in order to get the most benefit from it. To help you remember, take it at the same time each day.

Side Effects

Constipation, diarrhea, or upset stomach may occur. These effects are usually temporary and may disappear as your body adjusts to this medication. If any of these effects last or get worse, contact your doctor or pharmacist promptly.

Iron may cause your stools to turn black, an effect that is not harmful.

If your doctor has prescribed this medication, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking this product, tell your doctor or pharmacist if you are allergic to any of its ingredients; or if you have any other allergies. This product may contain inactive ingredients (such as soy found in some brands), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before taking this medication, tell your doctor or pharmacist your medical history, especially of: iron overload disorder (such as hemochromatosis, hemosiderosis), use/abuse of alcohol, liver problems, stomach/intestinal problems (such as ulcer, colitis).

If your brand of multivitamin also contains folic acid, be sure to tell your doctor or pharmacist if you have vitamin B12 deficiency (pernicious anemia) before taking it. Folic acid may affect certain laboratory tests for vitamin B12 deficiency without treating this anemia. Untreated vitamin B12 deficiency may result in serious nerve problems (such as peripheral neuropathy). Consult your doctor or pharmacist for details.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Tell your doctor if you are pregnant before using this medication.

This medication passes into breast milk. Consult your doctor before breast-feeding.

Interactions

See also How To Use section.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

This product can decrease the absorption of other drugs such as bisphosphonates (for example, alendronate), levodopa, penicillamine, quinolone antibiotics (for example, ciprofloxacin, levofloxacin), thyroid medications (for example, levothyroxine), and tetracycline antibiotics (for example, doxycycline, minocycline). Separate your doses of these medications as far as possible from your doses of this product. Ask your doctor or pharmacist about how long you should wait between doses and for help finding a dosing schedule that will work with all your medications.

If your brand of multivitamin also contains folic acid, be sure to tell your doctor or pharmacist if you take certain anti-seizure drugs (such as hydantoins such as phenytoin).

This medication may interfere with certain lab tests, possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug.

Does One-A-Day WOMEN’s interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: stomach pain, nausea, vomiting, diarrhea.

If your doctor has prescribed this medication, do not share it with others.

Keep all medical and lab appointments.

Some brands may also contain ingredients such as docusate. Ask your doctor or pharmacist if you have questions about the ingredients in your brand.

This product is not a substitute for a proper diet. Remember that it is best to get your vitamins and minerals from healthy foods. Maintain a well-balanced diet and follow any dietary guidelines as directed by your doctor.

If you are taking this product on a prescribed schedule and miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Images

One-A-Day Womens Formula 18 mg iron-400 mcg-500 mg Ca tablet

Color: yellowShape: oblongImprint: ONE A DAY and logo

This medicine is a yellow, oblong, tablet imprinted with “ONE A DAY and logo”.

One-A-Day Womens Formula 18 mg iron-400 mcg-500 mg Ca tablet

Color: yellowShape: oblongImprint: logo

This medicine is a yellow, oblong, tablet imprinted with “ONE A DAY and logo”.

One-A-Day Womens Formula 18 mg iron-400 mcg-500 mg Ca tablet

Color: yellowShape: oblongImprint: logo

This medicine is a yellow, oblong, tablet imprinted with “ONE A DAY and logo”.

Next

Save up to 80% on your prescriptions.

Available coupons

Save up to 80% on your prescription with WebMDRx

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

One-A-Day Women’S 50 Plus Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Warnings:

If your brand of multivitamin contains iron, it is important to keep this product out of reach of children. Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children younger than 6 years. If overdose does occur, get medical help right away or call a poison control center.

Warnings:

If your brand of multivitamin contains iron, it is important to keep this product out of reach of children. Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children younger than 6 years. If overdose does occur, get medical help right away or call a poison control center.

… Show More

Uses

This medication is a multivitamin product used to treat or prevent vitamin deficiency due to poor diet, certain illnesses, or during pregnancy. Vitamins are important building blocks of the body and help keep you in good health.

How to use One-A-Day Women’s 50 Plus

Take this medication by mouth, usually once daily or as directed. Follow all directions on the product package, or take as directed by your doctor. Do not take more than the recommended dosage. If you have any questions, ask your doctor or pharmacist.

Take this medication regularly in order to get the most benefit from it. To help you remember, take it at the same time each day.

Side Effects

Constipation, diarrhea, or upset stomach may occur. These effects are usually temporary and may disappear as your body adjusts to this medication. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

If your doctor has prescribed this medication, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US –

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking this product, tell your doctor or pharmacist if you are allergic to any of its ingredients; or to soy/peanut found in some brands; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before taking this medication, tell your doctor or pharmacist your medical history, especially of: use/abuse of alcohol, liver problems, stomach/intestinal problems (such as ulcer, colitis).

If your brand of multivitamin also contains folic acid, be sure to tell your doctor or pharmacist if you have vitamin B12 deficiency (pernicious anemia) before taking it. Folic acid may affect certain laboratory tests for vitamin B12 deficiency without treating this anemia. Untreated vitamin B12 deficiency may result in serious nerve problems (such as peripheral neuropathy). Consult your doctor or pharmacist for details.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Tell your doctor if you are pregnant before using this medication.

This medication passes into breast milk. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

If your brand of multivitamin also contains iron, avoid taking this product at the same time as antacids, bisphosphonates (for example, alendronate), levodopa, thyroid medications (for example, levothyroxine), or some antibiotics (for example, tetracyclines, quinolones such as ciprofloxacin). Ask your doctor or pharmacist about how long you should wait between doses and for help finding a dosing schedule that will work with all your medications.

If your brand of multivitamin also contains folic acid, be sure to tell your doctor or pharmacist if you take certain anti-seizure drugs (including hydantoins such as phenytoin).

This medication may interfere with certain lab tests, possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug.

Does One-A-Day Women’s 50 Plus interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: stomach pain, nausea, vomiting, diarrhea.

Keep all medical and lab appointments.

Some brands may also contain ingredients such as docusate. Ask your doctor or pharmacist if you have questions about the ingredients in your brand.

This product is not a substitute for a proper diet. Remember that it is best to get your vitamins from healthy foods. Maintain a well-balanced diet and follow any dietary guidelines as directed by your doctor.

If you are taking this product on a prescribed schedule and miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Images

Next

Save up to 80% on your prescriptions.

Available coupons

Save up to 80% on your prescription with WebMDRx

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Today on WebMD

90,000 can you lose weight using Ozempic Injection Medication for Diabetes?

A rumor has gone viral on the Internet that celebrities, led by Kim Kardashian, are losing weight with the help of injections of a diabetes drug. Figured it out together with experts, is it true that “magic injections” will help to part with extra pounds? Does this remedy have contraindications? (Spoiler – yes.) And is it possible to assign it to yourself? (Spoiler – of course not. )

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health

grooming

Rules of Life

Even if you don’t follow the Kardashian family, it’s almost impossible to avoid news about them. So it is likely that you have come across photographs of a noticeably thinner Kim Kardashian. The star and businesswoman emphasizes her figure with the help of tight-fitting outfits, and tells reporters and fans that strict restrictions helped her achieve the effect. She completely eliminated sugar and carbohydrates, and also trains twice a day in a sauna suit. True, there was a rumor on the Internet that Kim (and she was not alone) was losing weight with the help of Ozempic injections.

Do not self-medicate! In our articles, we collect the latest scientific data and the opinions of authoritative health experts. But remember: only a doctor can diagnose and prescribe treatment.

One of the sources of the “sensation” was the comedian Heather McDonald. On the Juicy Scoop podcast, she stated something like this: “A lot of people are wondering how the Kardashians lose weight so quickly and their bodies completely transform. Everyone discusses this topic and mentions the Ozempic medicine.

Ozempic is the brand name under which the Danish pharmaceutical company Novo Nordisk sells semaglutide injectables. It is injected once a week in the buttock or abdomen to treat type 2 diabetes. Back in 2021, experts proved the effectiveness of the drug against obesity and overweight. Almost 2,000 overweight people took part in the study, and those who received semaglutide (rather than placebo) lost an average of 15% of their total body weight.

“Semaglutide is an analogue of glucagon-like peptide-1 (GLP-1), a natural hormone of the body that is involved in glucose metabolism and also helps regulate appetite,” explains Hovhannes Vagenovich Davidyan, a general practitioner, a specialist in integrative anti-age- medicine “Life Med Center”. “Ozempic and other type 2 diabetes medications can actually help with weight loss. By acting on specific receptors in the body, they suppress appetite and slow down the process of digestion. As a result, a person feels less hungry, feels fuller faster, and consumes fewer calories.”

New York plastic surgeon David Schafer confirmed to WWD that he has been using Ozempic in his clinic for more than a year and the popularity of this drug is only growing. About 20 patients apply for injections every day, and everyone is ready to pay from $1,000 to $1,400 per month. After all, insurance does not cover such use of the drug. Schafer himself, thanks to Ozempic, lost 20 pounds (about 9 kg), and one of his employees lost 30 pounds (about 13 kg). When asked about side effects, the doctor reports the following: “When I eat cheese or fatty foods, I feel sick. But that’s all.”

The same semaglutide is produced under the brand name Wegovy (this drug is not registered in Russia), and Elon Musk has already admitted to using it. Therefore, the sudden interest in Ozempic and its active discussion are reminiscent of viral marketing. After all, everyone knows that the name Kardashian helps to sell anything: from cosmetics to slimming underwear.

And in general, weight management with the help of diabetic drugs is not a new story. For example, our endocrinologists often prescribe metformin for this purpose (Glucophage, Metadiene, etc.). This drug promotes the rapid oxidation of fatty acids, prevents the active absorption of carbohydrates, lowers cholesterol and glucose levels in the blood, and also suppresses hunger caused by low levels of the hormone insulin. In addition, we have registered and produce Saxenda, which is an analogue of Ozempic.

An important disclaimer: only a doctor can prescribe such drugs and choose the right dosage based on the results of the tests. In addition, he must warn about side effects and make sure that you are allowed such therapy for health reasons. “There are plenty of contraindications for such drugs. These are pregnancy, breastfeeding, problems with the pancreas or kidneys,” says Hovhannes Vagenovich. – In addition, the instructions describe a huge number of side effects: pancreatitis, hypoglycemia, kidney failure, visual impairment, allergic reactions, problems with the gallbladder. Of course, such reactions are rather rare. The most common side effects are nausea, vomiting, abdominal pain, and constipation.”

“Personally, I consider the use of diabetic drugs for body shaping extremely unsafe,” says Elena Krokhmaleva, PhD in Biology, senior researcher at the St. Petersburg Institute of Bioregulation and Gerontology, gerontologist, nutritionist. — Yes, they regulate the level of glucose in the blood and restore the normal functioning of the pancreas. And yet they have too many contraindications. Is a slender figure worth planting a liver and kidneys? It is much wiser to add at least moderate physical activity and balance the diet. And you can help yourself with the help of vitamins and herbal dietary supplements. For example, vitamin D and omega regulate metabolism, promoting weight loss. There have also been publications on the positive effect of mulberry extract on weight loss. The result will not be so fast, but physiological and without side effects for the body. ”

It is important to understand: neither metformin nor semaglutide burn fat on their own, but only create favorable conditions for getting rid of it. Along with taking the drug, it is recommended to go in for sports and adhere to a strict diet (remove starchy foods and sweets, as well as exclude alcohol). It will not be possible to achieve a noticeable result without additional efforts on your part. Or it won’t last long. “I recommend doing 10-15 thousand steps a day, regardless of whether you are taking any additional drugs or not,” says Ovanes Vagenovich. – And if you want to make the body more prominent, you need to add strength training and functional training. And it is important to remember that when one or another drug therapy is stopped, there is a high probability of a withdrawal syndrome and a return of weight to baseline. So the lifestyle will still have to be adjusted. And whether it is worth additionally helping the body with drugs for diabetes – you need to decide together with a qualified specialist. And if you resort to such help, then do it under control!”

Ingavirin® for adults — an innovative antiviral drug to fight influenza and SARS

Pharmacodynamics

Antiviral drug.

Preclinical and clinical studies have shown the efficacy of Ingavirin® against influenza A (A(h2N1), including the pandemic strain A(h2N1)pdm09 (“pork”), A(h4N2), A( H5N1)) and type B, adenovirus, parainfluenza virus, respiratory syncytial virus; in preclinical studies: coronavirus, metapneumovirus, enteroviruses, including Coxsackie virus and rhinovirus. In a clinical study in outpatients with COVID-19mild course of the drug Ingavirin® reduced the time to clinical recovery.

The mechanism of action is realized at the level of infected cells due to the activation of innate immunity factors suppressed by viral proteins. In experimental studies, in particular, it has been shown that Ingavirin® increases the expression of the first type of interferon receptor IFNAR on the surface of epithelial and immunocompetent cells. An increase in the density of interferon receptors leads to an increase in the sensitivity of cells to the signals of endogenous interferon. The process is accompanied by activation (phosphorylation) of the STAT1 transmitter protein, which transmits a signal to the cell nucleus to induce the synthesis of antiviral genes. It has been shown that under conditions of infection, the drug activates the synthesis of the antiviral effector protein MxA (an early antiviral response factor that inhibits the intracellular transport of ribonucleoprotein complexes of various viruses) and the phosphorylated form of PKR, which suppresses the translation of viral proteins, thus slowing down and stopping the process of viral reproduction.

The effect of Ingavirin® is to significantly reduce the signs of the cytopathic and cytodestructive effects of the virus, reduce the number of infected cells, limit the pathological process, normalize the composition and structure of cells and the morphological pattern of tissues in the area of ​​the infectious process, both in the early and late stages .

The anti-inflammatory effect is due to the suppression of the production of key pro-inflammatory cytokines (tumor necrosis factor (TNF-α), interleukins (IL-1β and IL-6)), a decrease in the activity of myeloperoxidase.

Experimental studies have shown that the combined use of Ingavirin® with antibiotics increases the effectiveness of therapy in a model of bacterial sepsis, including those caused by penicillin-resistant strains of staphylococcus.

Conducted experimental toxicological studies indicate a low level of toxicity and a high safety profile of the drug.

According to the parameters of acute toxicity, the drug Ingavirin® belongs to the 4th class of toxicity – “Low-toxic substances” (during the determination of LD50 in experiments on acute toxicity, lethal doses of the drug could not be determined).

The drug does not have mutagenic, immunotoxic, allergenic and carcinogenic properties, does not have a local irritating effect. The drug Ingavirin® does not affect the reproductive function, does not have an embryotoxic and teratogenic effect.

There is no effect of the drug Ingavirin® on the hematopoietic system when taking the age-appropriate dose according to the recommended regimen and course.

Pharmacokinetics

Absorption and distribution.

In an experiment using a radioactive label, it was found that the drug quickly enters the bloodstream from the gastrointestinal tract, distributing through the internal organs. Peak concentrations in blood, plasma and most organs are reached 30 minutes after drug administration. The AUC values ​​(area under the concentration-time pharmacokinetic curve) of the kidneys, liver and lungs slightly exceed the blood AUC (43.77 μg h / g). The AUC values ​​for the spleen, adrenal glands, lymph nodes and thymus are lower than the blood AUC. MRT (mean drug retention time) in the blood – 37.2 hours.

With a course of taking the drug once a day, it accumulates in the internal organs and tissues. At the same time, the qualitative characteristics of the pharmacokinetic curves after each injection of the drug are identical: a rapid increase in the concentration of the drug after each injection 0.