About all

Pravastatin Side Effects in Elderly: Essential Information for Senior Health

What are the common pravastatin side effects in elderly patients. How can seniors manage these side effects effectively. What should older adults know about taking pravastatin safely.

Содержание

Understanding Pravastatin and Its Role in Elderly Healthcare

Pravastatin is a widely prescribed medication belonging to the statin class of drugs. It plays a crucial role in managing high cholesterol levels, particularly in elderly patients who are often at higher risk for cardiovascular diseases. This medication works by reducing the amount of cholesterol produced by the liver, thereby helping to lower “bad” cholesterol (LDL) and triglycerides while raising “good” cholesterol (HDL) levels in the blood.

For seniors, pravastatin can be an essential part of a comprehensive cardiovascular health strategy. However, as with any medication, it’s important to be aware of potential side effects, especially in older adults who may be more susceptible to adverse reactions due to age-related physiological changes and potential drug interactions.

Common Pravastatin Side Effects in Elderly Patients

While pravastatin is generally considered safe and well-tolerated, elderly patients may experience certain side effects. It’s crucial for seniors and their caregivers to be aware of these potential reactions:

  • Muscle pain and weakness
  • Joint pain
  • Headaches
  • Nausea and vomiting
  • Diarrhea or constipation
  • Difficulty sleeping
  • Dizziness
  • Fatigue

Is muscle pain a common side effect of pravastatin in elderly patients? Indeed, muscle-related symptoms are among the most frequently reported side effects. This can range from mild discomfort to more severe muscle pain, known as myalgia. In rare cases, pravastatin may cause a serious condition called rhabdomyolysis, which involves the breakdown of muscle tissue.

Managing Pravastatin Side Effects in Seniors

Effective management of pravastatin side effects is crucial for ensuring the medication’s benefits outweigh any potential risks. Here are some strategies that healthcare providers may recommend:

  1. Dose adjustment: Your doctor may consider lowering the pravastatin dosage to reduce side effects while maintaining its cholesterol-lowering benefits.
  2. Timing of medication: Taking pravastatin at a different time of day may help alleviate certain side effects, such as sleep disturbances.
  3. Dietary modifications: Implementing a heart-healthy diet can complement pravastatin’s effects and potentially allow for a lower dose.
  4. Exercise: Regular, gentle exercise may help mitigate muscle-related side effects and improve overall cardiovascular health.
  5. Supplements: In some cases, your healthcare provider might recommend supplements like Coenzyme Q10 to help manage muscle-related side effects.

Are there alternative medications for elderly patients who experience severe side effects from pravastatin? Yes, there are other cholesterol-lowering medications available. Your doctor may consider switching to a different statin or exploring non-statin alternatives if pravastatin side effects become problematic.

Monitoring and Regular Check-ups for Elderly Pravastatin Users

Regular monitoring is essential for elderly patients taking pravastatin. This typically involves:

  • Periodic blood tests to check liver function and cholesterol levels
  • Assessment of muscle symptoms and overall well-being
  • Evaluation of potential drug interactions with other medications
  • Monitoring for signs of cognitive changes or memory issues

How often should elderly patients on pravastatin have their liver function checked? Generally, liver function tests are recommended before starting pravastatin therapy and periodically thereafter, typically every 3-12 months, depending on individual risk factors and your doctor’s assessment.

Pravastatin Interactions and Precautions for Older Adults

Elderly patients often take multiple medications, increasing the risk of drug interactions. Some medications that may interact with pravastatin include:

  • Certain antibiotics (e.g., erythromycin, clarithromycin)
  • Antifungal medications (e.g., itraconazole, ketoconazole)
  • Immunosuppressants (e.g., cyclosporine)
  • Other cholesterol-lowering drugs (e.g., gemfibrozil, niacin)

Can elderly patients take pravastatin with grapefruit juice? It’s generally advisable for seniors to avoid consuming large amounts of grapefruit or grapefruit juice while taking pravastatin, as it can increase the concentration of the drug in the bloodstream, potentially leading to side effects.

Special Considerations for Elderly Patients with Kidney or Liver Issues

Elderly patients with kidney or liver problems may require special attention when taking pravastatin. These conditions can affect how the body processes the medication, potentially increasing the risk of side effects. Your healthcare provider may recommend:

  • Lower starting doses
  • More frequent monitoring of kidney and liver function
  • Careful assessment of the risk-benefit ratio

Lifestyle Modifications to Enhance Pravastatin Efficacy in Seniors

While pravastatin is effective in managing cholesterol levels, combining it with lifestyle modifications can enhance its benefits and potentially reduce the required dosage, thereby minimizing side effects. Elderly patients should consider:

  • Adopting a heart-healthy diet rich in fruits, vegetables, whole grains, and lean proteins
  • Engaging in regular, moderate exercise as approved by their healthcare provider
  • Maintaining a healthy weight
  • Quitting smoking
  • Limiting alcohol consumption

How much exercise is recommended for elderly patients taking pravastatin? The amount and type of exercise should be tailored to each individual’s health status and capabilities. Generally, aim for at least 150 minutes of moderate-intensity aerobic activity or 75 minutes of vigorous-intensity aerobic activity per week, along with muscle-strengthening activities at least twice a week. Always consult with your healthcare provider before starting a new exercise regimen.

Recognizing and Responding to Serious Pravastatin Side Effects in the Elderly

While rare, pravastatin can cause serious side effects that require immediate medical attention. Elderly patients and their caregivers should be vigilant for signs of:

  • Severe muscle pain or weakness
  • Dark-colored urine
  • Yellowing of the skin or eyes (jaundice)
  • Unexplained fatigue
  • Upper right abdominal pain
  • Memory problems or confusion

What should an elderly patient do if they suspect a serious side effect from pravastatin? If any of these symptoms occur, discontinue the medication immediately and seek urgent medical care. Prompt attention can prevent potential complications and ensure appropriate treatment.

Reporting Side Effects and Pharmacovigilance in Elderly Patients

Reporting side effects is crucial for ongoing medication safety monitoring, especially in vulnerable populations like the elderly. Patients, caregivers, and healthcare providers can report adverse effects to:

  • The prescribing physician
  • The local pharmacy
  • The FDA’s MedWatch program

This information helps in refining prescribing guidelines and improving medication safety for all patients.

Alternative Cholesterol Management Strategies for Seniors

For elderly patients who cannot tolerate pravastatin or other statins, alternative cholesterol management strategies may be considered:

  • Other classes of cholesterol-lowering medications (e.g., ezetimibe, PCSK9 inhibitors)
  • Omega-3 fatty acid supplements
  • Plant sterols and stanols
  • Fiber supplements
  • Intensive lifestyle modifications

Are natural alternatives to pravastatin effective for elderly patients? While some natural alternatives may have cholesterol-lowering effects, their efficacy is generally not as robust as prescription medications. Always consult with your healthcare provider before considering natural alternatives, as they may interact with other medications or have their own side effects.

Patient Education and Support for Elderly Pravastatin Users

Educating elderly patients and their caregivers about pravastatin use is essential for ensuring medication adherence and safety. Key points to emphasize include:

  • The importance of taking the medication as prescribed
  • Potential side effects and when to seek medical attention
  • The need for regular check-ups and blood tests
  • Dietary and lifestyle recommendations
  • Proper storage and handling of the medication

How can elderly patients remember to take their pravastatin regularly? Establishing a consistent routine, using pill organizers, setting reminders on smartphones or other devices, and enlisting the help of family members or caregivers can all be effective strategies for improving medication adherence in seniors.

Support Groups and Resources for Elderly Patients on Pravastatin

Joining support groups or accessing educational resources can be beneficial for elderly patients taking pravastatin. These may include:

  • Local senior center health programs
  • Online forums for patients with high cholesterol
  • Educational materials from reputable health organizations
  • Medication management apps designed for seniors

Engaging with these resources can provide valuable information, emotional support, and practical tips for managing pravastatin use and overall cardiovascular health.

Future Developments in Cholesterol Management for Elderly Patients

Research into cholesterol management for elderly patients is ongoing, with promising developments on the horizon:

  • New classes of cholesterol-lowering medications with potentially fewer side effects
  • Personalized medicine approaches based on genetic profiles
  • Advanced monitoring techniques for early detection of side effects
  • Innovative drug delivery systems for improved efficacy and reduced side effects

These advancements may offer more tailored and safer options for managing cholesterol in the elderly population in the future.

What role might artificial intelligence play in managing pravastatin therapy for elderly patients? AI could potentially assist in predicting individual responses to pravastatin, optimizing dosages, and identifying patients at higher risk for side effects, leading to more personalized and safer treatment strategies.

Conclusion: Balancing Benefits and Risks of Pravastatin in Elderly Care

Pravastatin remains an important tool in managing cholesterol levels and reducing cardiovascular risk in elderly patients. While side effects can occur, many are manageable with proper monitoring and care. The key to successful pravastatin therapy in seniors lies in:

  • Individualized treatment plans
  • Regular monitoring and follow-up
  • Open communication between patients, caregivers, and healthcare providers
  • Balancing medication use with lifestyle modifications
  • Staying informed about potential side effects and knowing when to seek help

By taking a comprehensive approach to pravastatin use in elderly patients, healthcare providers can help ensure that the benefits of this medication outweigh the potential risks, contributing to improved cardiovascular health and quality of life for seniors.

Pravastatin Side Effects in Elderly: What You Need to Know

Pravastatin is a commonly prescribed medication for managing high cholesterol levels. While it is generally considered safe, there are potential side effects that can occur, especially in elderly patients. In this blog post, we’ll explore the most common pravastatin side effects in elderly patients and how Nao Medical can help you manage them.

Common Pravastatin Side Effects in Elderly Patients

  • Muscle pain and weakness
  • Joint pain
  • Headaches
  • Nausea and vomiting
  • Diarrhea
  • Constipation
  • Difficulty sleeping
  • Dizziness
  • Fatigue

If you experience any of these side effects while taking pravastatin, it’s important to talk to your healthcare provider. They may recommend adjusting your dosage or switching to a different medication.

How Nao Medical Can Help

At Nao Medical, we specialize in providing comprehensive healthcare services to patients of all ages, including geriatric care. Our team of experienced healthcare providers can help you manage your pravastatin side effects and ensure that you’re getting the care you need to stay healthy.

When you book an appointment with Nao Medical, you’ll have access to our state-of-the-art facilities, technologically driven approach, and exceptional staff. We offer same-day appointments, minimal wait times, and extensive after-hours virtual care to ensure that you always have access to the care you need.

FAQs

What is pravastatin?

Pravastatin is a medication used to manage high cholesterol levels.

What are the most common side effects of pravastatin?

The most common side effects of pravastatin include muscle pain and weakness, joint pain, headaches, nausea and vomiting, diarrhea, constipation, difficulty sleeping, dizziness, and fatigue.

Can pravastatin cause serious side effects?

In rare cases, pravastatin can cause serious side effects such as liver damage, muscle damage, and kidney problems. If you experience any of these symptoms, it’s important to seek medical attention right away.

How can I manage my pravastatin side effects?

Your healthcare provider may recommend adjusting your dosage or switching to a different medication to manage your pravastatin side effects. They may also recommend lifestyle changes such as exercise and a healthy diet.

How can I book an appointment with Nao Medical?

You can book an appointment with Nao Medical by visiting our website at https://www.nao.md/geriatrics or by calling us at (917) 310-3371.

Key Takeaways

  • Pravastatin is a medication used to manage high cholesterol levels.
  • The most common side effects of pravastatin in elderly patients include muscle pain and weakness, joint pain, headaches, nausea and vomiting, diarrhea, constipation, difficulty sleeping, dizziness, and fatigue.
  • If you experience any of these side effects, it’s important to talk to your healthcare provider.
  • Nao Medical can help you manage your pravastatin side effects and ensure that you’re getting the care you need to stay healthy.
  • Book an appointment with Nao Medical today to get the care you deserve.

Disclaimer: The information presented in this article is intended for general informational purposes only and should not be considered, construed or interpreted as legal or professional advice, guidance or opinion.

Pravastatin Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Uses

Pravastatin is used along with a proper diet to help lower “bad” cholesterol and fats (such as LDL, triglycerides) and raise “good” cholesterol (HDL) in the blood. It belongs to a group of drugs known as “statins.” It works by reducing the amount of cholesterol made by the liver. Lowering “bad” cholesterol and triglycerides and raising “good” cholesterol decreases the risk of heart disease and helps prevent strokes and heart attacks. In addition to eating a proper diet (such as a low-cholesterol/low-fat diet), other lifestyle changes that may help this medication work better include exercising, losing weight if overweight, and stopping smoking. Consult your doctor for more details.

How to use Pravastatin SODIUM

Take this medication by mouth with or without food as directed by your doctor, usually once daily.

The dosage is based on your medical condition, response to treatment, age, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

If you also take certain other drugs to lower your cholesterol (bile acid-binding resins such as cholestyramine or colestipol), take pravastatin at least 1 hour before or at least 4 hours after taking these medications. These products can react with pravastatin, preventing its full absorption.

Take this medication regularly in order to get the most benefit from it. Remember to take it at the same time each day. Keep taking this medication even if you feel well. Most people with high cholesterol or triglycerides do not feel sick.

It is very important to continue to follow your doctor’s advice about diet and exercise. It may take up to 4 weeks before you get the full benefit of this drug.

Side Effects

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A very small number of people taking pravastatin may have mild memory problems or confusion. If these rare effects occur, talk to your doctor.

Rarely, statins may cause or worsen diabetes. Talk to your doctor about the benefits and risks.

This drug may rarely cause muscle problems (which can rarely lead to very serious conditions called rhabdomyolysis and autoimmune myopathy). Tell your doctor right away if you develop any of these symptoms during treatment and if these symptoms last after your doctor stops this drug: muscle pain/tenderness/weakness (especially with fever or unusual tiredness), signs of kidney problems (such as change in the amount of urine).

This medication may rarely cause liver problems. Tell your doctor right away if you develop symptoms of liver problems, including: nausea/vomiting that doesn’t stop, yellowing eyes/skin, dark urine, stomach/abdominal pain.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking pravastatin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, alcohol use.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Limit alcoholic beverages. Daily use of alcohol may increase your risk for liver problems, especially when combined with pravastatin. Ask your doctor or pharmacist for more information.

Older adults may be more sensitive to the side effects of this drug, especially muscle problems.

During pregnancy, this medication should be used only when clearly needed. It may harm an unborn baby. Discuss the risks and benefits with your doctor.

This medication passes into breast milk and may have undesirable effects on a nursing infant. Breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.

Interactions

See also How To Use section.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Some products that may interact with this drug include: colchicine, daptomycin, gemfibrozil.

Do not take any red yeast rice products while you are taking pravastatin because some red yeast rice products may also contain a statin called lovastatin. Taking pravastatin and red yeast rice products together can increase your risk of serious muscle and liver problems.

Does Pravastatin SODIUM interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Do not share this medication with others.

Lab and/or medical tests (such as blood cholesterol/triglyceride levels, liver function) should be done while you are taking this medication. Keep all medical and lab appointments. Consult your doctor for more details.

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Images

pravastatin 20 mg tablet

Color: off-whiteShape: roundImprint: APO PRA 20

This medicine is a off-white, round, tablet imprinted with “APO” and “PRA 20”.

pravastatin 20 mg tablet

Color: yellowShape: rectangular (rounded end)Imprint: PB 2

This medicine is a off-white, round, tablet imprinted with “APO” and “PRA 20”.

pravastatin 10 mg tablet

Color: light pinkShape: roundImprint: APO PRA 10

This medicine is a off-white, round, tablet imprinted with “APO” and “PRA 20”.

pravastatin 40 mg tablet

Color: light greenShape: roundImprint: APO PRA 40

This medicine is a off-white, round, tablet imprinted with “APO” and “PRA 20”.

pravastatin 20 mg tablet

Color: yellowShape: rectangular (rounded end)Imprint: G5 20

This medicine is a off-white, round, tablet imprinted with “APO” and “PRA 20”.

pravastatin 10 mg tablet

Color: yellowShape: roundImprint: G5 10

This medicine is a off-white, round, tablet imprinted with “APO” and “PRA 20”.

pravastatin 80 mg tablet

Color: off-whiteShape: roundImprint: PRA 80 APO

This medicine is a off-white, round, tablet imprinted with “APO” and “PRA 20”.

pravastatin 20 mg tablet

Color: whiteShape: ovalImprint: ZC45

This medicine is a off-white, round, tablet imprinted with “APO” and “PRA 20”.

pravastatin 80 mg tablet

Color: yellowShape: ovalImprint: G5 80

This medicine is a off-white, round, tablet imprinted with “APO” and “PRA 20”.

pravastatin 40 mg tablet

Color: greenShape: rectangular (rounded end)Imprint: G5 40

This medicine is a off-white, round, tablet imprinted with “APO” and “PRA 20”.

pravastatin 40 mg tablet

Color: light greenShape: rectangular (rounded end)Imprint: PB 8

This medicine is a off-white, round, tablet imprinted with “APO” and “PRA 20”.

pravastatin 80 mg tablet

Color: yellowShape: ovalImprint: PB 4

This medicine is a off-white, round, tablet imprinted with “APO” and “PRA 20”.

pravastatin 10 mg tablet

Color: pinkShape: rectangular (rounded end)Imprint: PB 1

This medicine is a off-white, round, tablet imprinted with “APO” and “PRA 20”.

pravastatin 80 mg tablet

Color: whiteShape: ovalImprint: RDY 274

This medicine is a off-white, round, tablet imprinted with “APO” and “PRA 20”.

pravastatin 40 mg tablet

Color: whiteShape: roundImprint: RDY 231

This medicine is a off-white, round, tablet imprinted with “APO” and “PRA 20”.

pravastatin 20 mg tablet

Color: whiteShape: roundImprint: RDY 230

This medicine is a off-white, round, tablet imprinted with “APO” and “PRA 20”.

pravastatin 10 mg tablet

Color: whiteShape: roundImprint: RDY 229

This medicine is a off-white, round, tablet imprinted with “APO” and “PRA 20”.

pravastatin 20 mg tablet

Color: light yellowShape: roundImprint: TEVA 7201

This medicine is a off-white, round, tablet imprinted with “APO” and “PRA 20”.

pravastatin 40 mg tablet

Color: light greenShape: roundImprint: TEVA 7202

This medicine is a off-white, round, tablet imprinted with “APO” and “PRA 20”.

pravastatin 10 mg tablet

Color: pinkShape: roundImprint: TEVA 771

This medicine is a off-white, round, tablet imprinted with “APO” and “PRA 20”.

pravastatin 20 mg tablet

Color: light yellowShape: roundImprint: 93 7201

This medicine is a off-white, round, tablet imprinted with “APO” and “PRA 20”.

pravastatin 80 mg tablet

Color: off-whiteShape: ovalImprint: TEVA 7270

This medicine is a off-white, round, tablet imprinted with “APO” and “PRA 20”.

pravastatin 80 mg tablet

Color: whiteShape: oblongImprint: logo PV 80

This medicine is a off-white, round, tablet imprinted with “APO” and “PRA 20”.

pravastatin 80 mg tablet

Color: off-whiteShape: ovalImprint: 93 7270

This medicine is a off-white, round, tablet imprinted with “APO” and “PRA 20”.

pravastatin 80 mg tablet

Color: off-whiteShape: ovalImprint: TEVA 7270

This medicine is a off-white, round, tablet imprinted with “APO” and “PRA 20”.

pravastatin 40 mg tablet

Color: light greenShape: roundImprint: 93 7202

This medicine is a off-white, round, tablet imprinted with “APO” and “PRA 20”.

pravastatin 40 mg tablet

Color: light greenShape: roundImprint: TEVA 7202

This medicine is a off-white, round, tablet imprinted with “APO” and “PRA 20”.

pravastatin 20 mg tablet

Color: light yellowShape: roundImprint: 93 7201

This medicine is a off-white, round, tablet imprinted with “APO” and “PRA 20”.

pravastatin 20 mg tablet

Color: light yellowShape: roundImprint: TEVA 7201

This medicine is a off-white, round, tablet imprinted with “APO” and “PRA 20”.

pravastatin 10 mg tablet

Color: pinkShape: roundImprint: TEVA 771

This medicine is a off-white, round, tablet imprinted with “APO” and “PRA 20”.

pravastatin 10 mg tablet

Color: pinkShape: roundImprint: 93 771

This medicine is a off-white, round, tablet imprinted with “APO” and “PRA 20”.

pravastatin 40 mg tablet

Color: whiteShape: ovalImprint: ZC44

This medicine is a off-white, round, tablet imprinted with “APO” and “PRA 20”.

pravastatin 40 mg tablet

Color: light greenShape: roundImprint: 93 7202

This medicine is a off-white, round, tablet imprinted with “APO” and “PRA 20”.

pravastatin 10 mg tablet

Color: whiteShape: ovalImprint: ZC46

This medicine is a off-white, round, tablet imprinted with “APO” and “PRA 20”.

pravastatin 40 mg tablet

Color: light brownShape: roundImprint: HLP 40

This medicine is a off-white, round, tablet imprinted with “APO” and “PRA 20”.

pravastatin 10 mg tablet

Color: light brownShape: roundImprint: HLP 10

This medicine is a off-white, round, tablet imprinted with “APO” and “PRA 20”.

Next

Save up to 80% on your prescriptions.

Available coupons

Save up to 80% on your prescription with WebMDRx

Drug Survey

Are you currently using Pravastatin SODIUM?

This survey is being conducted by the WebMD marketing sciences department.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Are statins dangerous for the elderly

The most common cause of human death is death from a disease of the cardiovascular system. In 2019, in Russia, the proportion of deaths from cardiovascular pathologies is 46% of the total number of non-violent deaths. According to the forecasts of the World Health Organization, this figure will only grow. The first statins, powerful cholesterol-lowering drugs, entered the general market as early as 1987 year. This medicine was supposed to save humanity, but a large number of myths and fears associated with this group of drugs hinder the fulfillment of a responsible mission.

What are statins

A large amount of cholesterol in the human body leads to the fact that it begins to settle on the walls of blood vessels, forming plaques that prevent blood flow. A plaque attached to a thrombus can block a vessel. This, in turn, can lead to disastrous consequences: from a heart attack to necrosis of the lower extremities. But not all cholesterol is “bad”. Cholesterol plays an important role in the proper functioning of the body, its tasks include:

  • Activation of metabolic processes;
  • Participation in the production of bile acids;
  • Protection of body cells from the influence of external stimuli.

And so, when our body gets too much LDL (low-density lipoprotein or “bad” cholesterol) and too little HDL (high-density lipoprotein or “good” cholesterol), problems begin. To prevent them, statins were invented.

Statins stop the production of an enzyme responsible for the formation of cholesterol. In addition, these drugs thin the blood and restore damaged vessel walls.

Who is prescribed statins

Since statins lower cholesterol levels, they are prescribed to the following categories of patients:

  • People with high blood cholesterol;
  • People who have had a heart attack
  • People suffering from coronary artery disease;
  • Persons with hypertension;
  • Patients with obesity, diabetes;
  • People with a hereditary predisposition;
  • Patients with acute coronary syndrome

Despite the fact that statins are effective in lowering cholesterol levels, they are not prescribed to all patients with high LDL levels.

Contraindications for statin treatment

  • Kidney and liver problems;
  • The period of bearing a child and breastfeeding;
  • Susceptibility to the components of the drug;

An important role in the practice of using statins is played by the fact that in Russia a very small percentage of patients take drugs after they are prescribed. If in America 95% of patients take drugs, in Europe this figure reaches 55%, then in our country it is a modest 12%. There are many reasons for this, including fear and distrust in medicine and the habit of most Russians to let everything “take its own course”.

Statins – for and against

Even half a century after the invention of statins, doctors continue to argue about the pros and cons of taking these drugs.

Benefits of using statins:

  • 20% reduction in cardiovascular disease mortality.
  • Patients taking statins have a 50% reduced risk of stroke and heart attack.
  • The new generation of drugs is absolutely safe and rarely leads to the development of side effects.
  • A wide range of choices, the medicine is never in short supply.
  • Promote vasodilation and reduce blood viscosity.
  • Decreased platelet aggregation.

Side effects of statins

Statins have a number of side effects, but the most common ones are not dangerous. Among them: sore throat, headache, unpleasant, pulling sensations in the muscles and chills. Recent studies show that statin use accelerates the aging of the body, which leads to a loss of energy and the development of weakness and fatigue. In addition, the disadvantages of these drugs include:

  • Relatively high cost.
  • Statins also reduce the production of mevalonate, which is the source of many important substances responsible for biological functions in the body.
  • Too low cholesterol is as dangerous as high cholesterol. Excessive use of statins can lead to the development of cancer, anemia and liver problems.

Myths about statins:

Diet can replace statins

A recent study by University of Toronto nutrition professor David Jenkins found that when people followed a special diet that included cholesterol-lowering foods, their LDL levels actually dropped.

The nuance is that the diet was made by professional doctors individually for each participant. At the same time, the experiment lasted six months and its results, although they were comparable to the effect of statins, were still worse. In practice, the average person is unlikely to strictly follow all the requirements of the diet, which can only harm themselves. Therefore, before embarking on such a diet, be sure to consult with a specialist.

Breaking statins won’t hurt

The prescribed drug should be taken daily. There are no “buts” here. If you take a break, then the cholesterol level will quickly return to its previous level and all treatment will go down the drain. Also, stopping treatment may increase or even exceed the initial level of cholesterol in the blood. The constant intake of these drugs leads to a decrease in the risk of side effects.

In addition, statins must be taken strictly in the evening, preferably one hour before bedtime and at a constant dosage. Previously, when prescribing, the tactics of gradually increasing the dose were used, but recent studies show that this does not lead to an improvement in the patient’s condition.

Statins cause diabetes mellitus

This statement is only partly true. Studies have shown that among almost 18 thousand subjects who took statins, only 275 people developed diabetes mellitus. At the same time, in patients taking placebo, it developed in 220 cases. This increase in the incidence is explained by the initial predisposition to diabetes in the subjects.

Statins kill the liver

Statins slow down the work of one of the main enzymes involved in the synthesis of cholesterol – GMC-CoA reductase. This leads to a decrease in the synthesis of cholesterol in the liver, but does not cause toxic effects. At the same time, statins are potent drugs prescribed for a long time. Therefore, if you have liver disease, then taking statins should be approached with caution. But even for such patients, pharmacists have developed special groups of drugs that reduce the risk of complications. Also, patients with hepatosis of the liver, hepatitis and other similar diseases while taking statins should follow a diet low in animal fats.

Should I take statins?

As a result, we get that statins are quite effective drugs, but at the same time, they have a number of side effects. For many older people, this medication is vital, so if your doctor has prescribed statins for you, in no case should you ignore this prescription, adjust the treatment regimen on your own, or skip medications. Everything is poison and everything is medicine. The difference is only in proper use. Physical activity, a well-chosen diet, timely and correct intake of the drug and regular consultations with a doctor will help reduce the risk of complications and provide you with a peaceful old age, despite problems with cholesterol.

Should statins be given to older people?

In May 2017, a collaborative original US study published in the Journal of the American Medical Association examines the rationale for using statins as primary prevention of cardiovascular disease in people over 65 years of age. This work was supported by the National Heart, Lung, and Blood Institute, Bethesda, USA, and the Clinical and Translational Science Institute, New York University, USA .

In recent decades, population aging has become a pressing problem almost all over the world. According to the US Census Bureau, 6 million people are aged ≥85 years, and this number is projected to increase to 9 million by 2030. Many older patients take statins for the primary prevention of cardiovascular disease (about 25%).

Until recently, statin avoidance for primary prevention was based primarily on risk patterns associated with cardiovascular disease. This risk model was characterized by inaccuracies in predicting cardiovascular events in groups of patients aged ≥85 years. The recently published United States Preventive Services Task Force Guidelines for the use of statins for primary prevention also point to the lack of justification for their use in older people (especially ≥76 years).

The choice of statins for primary prevention of cardiovascular disease is associated with a relative reduction in the proportion of atherosclerotic components of the incidence in the elderly, confirmed by several large clinical trials. However, given the inconsistency of the data, in particular those obtained in groups of people over 75 years old, the authors suggested the presence of a heterogeneous effect of statins in the indicated age category.

Despite the potential benefits of statins as primary cardiovascular prevention, even minor side effects in the elderly can cause irreparable harm.

The study in question showed that prescribing statins for the primary prevention of cardiovascular disease did not reduce mortality from cumulative causes or coronary heart disease in a subgroup of people over 65 years of age with hypertension and moderate hypercholesterolemia. The authors even noted a slight increase in cumulative-cause mortality among people over the age of 75 who took pravastatin. The use of statins may cause adverse effects on the function or health of the elderly, and these adverse events may offset any possible benefits of the effects of drugs on the cardiovascular system.

The use of statins can affect the physical and even mental health of the elderly, putting them at higher risk of death. Compared with young people, the risk of developing myopathy and rhabdomyolysis as a side effect of taking statins for patients over the age of 65 years is 5 times higher. Among the negative effects of statins: energy metabolism disorders, decreased exercise tolerance, cognitive depression, especially in people with pre-existing moderate impairments or dementia.

Observational studies conducted by scientists around the world have shown conflicting results regarding the benefit of statin therapy for the primary prevention of cardiovascular disease in the elderly. A large prospective study of pravastatin in elderly people at risk was carried out as part of a large clinical trial to eliminate lipid metabolism disorders. Another large randomized trial that included a significant number of older adults (5695 people over the age of 70) did not confirm the grounds for the use of statins in the prevention of cardiovascular diseases.

The value of this study is the large number of participants involved in the elderly group at increased risk of developing cardiovascular disease.