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Pravastatin Side Effects Reviews: Effectiveness, Ease of Use, and Satisfaction

by alexxlab

What is the effectiveness of pravastatin?. How easy is pravastatin to use?. Are users satisfied with pravastatin?.

Pravastatin’s Effectiveness in Lowering Cholesterol

Many users report that pravastatin has been effective in lowering their cholesterol levels. One user, a 45-year-old male with blood pressure and cholesterol issues, stated that the drug “worked great” in improving his high-good cholesterol and low-bad cholesterol, with his levels averaging around 130. However, some users have had mixed experiences with pravastatin’s effectiveness. A user with high cholesterol and triglyceride levels reported that the medication “lowered my cholesterol to normal levels,” while another user taking 10mg of pravastatin said it lowered their cholesterol after 3 months, but they developed various side effects like soreness, weakness, and vision issues.

Ease of Use of Pravastatin

The ease of use of pravastatin seems to vary among users. Some find it easy to take, with one user stating they have not had any side effects. However, other users have reported difficulties, such as a user who tried switching the timing of their dose from night to morning but still experienced the same problems. Another user mentioned that the hassle of the side effects, like frequent urination and difficulty urinating, made the medication not worth the trouble for the amount of risk reduction provided.

User Satisfaction with Pravastatin

User satisfaction with pravastatin appears to be mixed. While some users are satisfied with the medication, reporting that it has effectively lowered their cholesterol without significant side effects, others have expressed dissatisfaction due to the various side effects they have experienced. A user who tried both atorvastatin and pravastatin reported severe mid-back pain, leg fatigue, knee pain, and other issues with pravastatin, leading to an overall “F-” rating for quality of life. Another user, who was put on pravastatin to prevent transient ischemic attacks after a COVID-19 booster shot, felt like they had “aged 100 years” due to the side effects and was unsure of the alternative options.

Comparison of Pravastatin to Other Statins

Some users have compared their experiences with pravastatin to other statins they have tried. One user mentioned that they had tried Lipitor and experienced terrible muscle aches, but found the pravastatin to be “okay” and improved their cholesterol numbers. Another user, who was initially prescribed atorvastatin but experienced too much muscle pain, was then put on pravastatin, which the doctor described as “weaker” and less likely to cause pain, but the user still experienced severe side effects like mid-back pain and leg fatigue.

Factors Influencing Pravastatin Effectiveness and Side Effects

Several factors seem to influence the effectiveness and side effects of pravastatin. One user mentioned that their cholesterol and blood pressure were otherwise normal, and they had passed stress tests easily, but their doctor still prescribed the statin, which they felt was an overly simplistic approach. Another user noted that the side effects they experienced, such as aching in their right foot, were not due to any injury, suggesting individual physiological differences may play a role in how people respond to the medication.

Considerations for Pravastatin Use

Based on the user reviews, it appears that while pravastatin can be effective in lowering cholesterol for some individuals, the ease of use and user satisfaction can vary significantly. Factors like individual physiology, the severity of one’s cholesterol issues, and the consideration of alternative treatment options seem to be important in determining the suitability of pravastatin for a given patient. Users and healthcare providers should carefully weigh the potential benefits and risks when deciding whether to use pravastatin or explore other treatment approaches.

Conclusion

In summary, the user reviews of pravastatin provide a mixed picture of its effectiveness, ease of use, and user satisfaction. While some users report positive experiences with the medication, others have faced significant side effects that have negatively impacted their quality of life. The reviews highlight the importance of considering individual factors and exploring alternative treatment options when managing cholesterol and related health conditions.

Effectiveness, Ease of Use, and Satisfaction

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Most voted positive review

64 People found this comment helpful

45 year old male…BP and cholesterol issues…My fault, not genetic…6’2″ 265 pounds…Drug worked great! high-good cholesterol, low-bad cholesterol-average 130’s…Wanna know why I stopped taking statins? No.1 reason-never had inflammation anywhere. Right metatarsal portion of my right foot would ache each morning until it was used for about 15 minutes of movement from no injury what so ever….

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Shared reviews and ratings

SORT BY Condition: Prevention of Transient Ischemic Attacks

Overall rating 3.0

EffectivenessEase of UseSatisfaction

After first COVID booster shot started having TIA’s, cholesterol was excellent, put on statin to negate blood clots. This is 3rd statin I have been on. Recently reduced from 40mg to 20mg. Prior never have been sick, no meds, exercised all the time, trim & fit, now feel like crap everyday, muscle aches, fatigue, abdo aches, foggy brain, forgetfulness, etc. Sometimes I have to drag myself out of bed in a.m. & still work full time. Dr. says have to stay on statin otherwise will end up with stroke in nursing home! On my own, took myself off statin for one month & TIA’s started again so started med again, guess the statin is doing the job of eliminating TIA’s but I feel like I have aged 100 years & I have no idea what the alternative is?? I read these posts & can so relate, thought I was the lone person out there.Read More Read Less

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Fill 3Created with Sketch. Condition: Combined High Blood Cholesterol and Triglyceride Level

Overall rating 5.0

EffectivenessEase of UseSatisfaction

This has lowered my cholesterol to normal levels and I have not had side effects. I tried Lipitor and I had terrible muscle aches. The Pravastatin has been okay and my numbers have improved a lot.

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Fill 3Created with Sketch. Condition: High Cholesterol

Overall rating 3.3

EffectivenessEase of UseSatisfaction

10mg. Lowered my cholesterol after 3 months. Developed soreness in shoulders and upper arms, weakness in legs, stumbling when walking, vision issues, frequent urination, visible loss of tone in biceps and forearm muscles, and ED (I’m an older guy but I’m not ready for that). Went off the meds for a while and felt much better, but LDL went up. Went back on but symptoms have returned after two months so I am quitting statins for good. This medication was prescribed for me as I am just over the line with diabetes and the LDL was up. But my blood pressure is very normal and I have passed stress tests easily. Doctor did not scan for any blockages, he simply prescribed the statin because his school book says I’m a candidate. Well, I think we are all individuals and we should be afforded a bit more thought and consideration before being force fed the drug of the day that has been successfully sold to the medical profession.by the pharmaceutical companiesRead More Read Less

1

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Fill 3Created with Sketch. Condition: Treatment to Prevent a Heart Attack

Overall rating 2.3

EffectivenessEase of UseSatisfaction

Age 64, female, LDL slightly high for 6 yrs before starting a statin. Tried Atorvastatin but too much muscle pain. So doc put me on Pravastatin, saying it was “weaker” and might not cause the pain. Wrong. Severe mid back pain that I was not having before I started Pravastatin. Leg fatigue (my apartment is a 3rd floor walk-up so I can say for sure I immediately notice leg fatigue). More knee pain than before. Lots of gas, frequent leakage of yellow bowel fluid that had never happened before, and the worst side effect for me is one not in the literature: now I have to get up to pee several times a night with an aching bladder and difficulty urinating. For quality of life, it gets an F-. When I complained my doc said to switch to taking it in the morning instead of night. It doesn’t matter — same problems. I also feel weird, which I can’t explain. For the amount of absolute risk reduction you get, even taking it 5 yrs, it hardly seems worth the trouble.Read More Read Less

1

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Fill 3Created with Sketch. Condition: Changes Involving Fatty Deposits in the Blood Vessels

Overall rating 2.3

EffectivenessEase of UseSatisfaction

Both upper arms developed excruciating pain. Difficult to sleep with the pain. Unexplained headaches that were stabbing, but not constant. Abdominal pain on right side. I got covid and had to stop taking it with Paxlovid. Within 3 days my arms and abdomen felt much better, and the headaches went away. This is the 2nd statin my doctor tried. I may be one of those people who cannot use statins. Another medication I take is Diltiazem, and I have untreated thyroid problems. Both may contribute to the statin problem. I am 75 years old.Read More Read Less

1

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Fill 3Created with Sketch. Condition: High Cholesterol

Overall rating 2.0

EffectivenessEase of UseSatisfaction

Within 3 months of taking prevastatin I found a severe decline in my muscles, but carried on taking for fear of consequences, plus declared it for a health policy and feared of them cancelling

1

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Fill 3Created with Sketch. Condition: High Cholesterol

Overall rating 4.3

EffectivenessEase of UseSatisfaction

So, after reading several of these comments it has sent my mind to wonder if some of my symptoms are caused by this drug. Muscle pain, fatigue, brain fog, hair loss, and dark urine even though I drink primarily water all day. I have been on this drug since 2019 and I’ve improved drastically since other than said above.

1

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Fill 3Created with Sketch. Condition: High Cholesterol

Overall rating 5.0

EffectivenessEase of UseSatisfaction

Taking pravastatin 20mg for one year to treat high cholesterol. Works fine for me, numbers are lower, not many side effects. ..a bit of occasional hip pain.

1

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Fill 3Created with Sketch. Condition: High Cholesterol

Overall rating 2.0

EffectivenessEase of UseSatisfaction

I am having severe gastritis, gas, bloating, memory fog, pain in joints and headaches on the left side of my head. I have only been taking this medication for 3 wks but I will not take anymore. I have suffered for this entire week with severe stomach pains. It feels like my insides are bruised.

1

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Fill 3Created with Sketch. Condition: High Cholesterol

Overall rating 1.0

EffectivenessEase of UseSatisfaction

I started 40 mg of Pravastatin, and within a week, I started feeling really sick. I was having cold like symptoms, along with a dry hacking cough. My doctor said I had a upper respiratory infection.

1

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Fill 3Created with Sketch. Condition: High Amount of Triglyceride in the Blood

Overall rating 2.3

EffectivenessEase of UseSatisfaction

It gave me severe muscle pain in thighs walking short distances. Not for me. Hopefully the damage it caused will correct itself.

1

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Fill 3Created with Sketch. Condition: High Amount of Triglyceride in the Blood

Overall rating 1.3

EffectivenessEase of UseSatisfaction

After four years I have developed weakness in my arms and legs. My vision has been blurry at times even with my glasses. I have gas after meals. Probably a major contributor to ED. My general practitioner suggested I go off the 20mg pills and see if I improve. I am still taking CO Q 10.

1

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Fill 3Created with Sketch. Condition: Combined High Blood Cholesterol and Triglyceride Level

Overall rating 3.0

EffectivenessEase of UseSatisfaction

I just filled my prescription of provachol. I have been on statins before. My NP that prescribed me the first statin said to take CO Q 10 for 2 weeks, and then start my script. She also said that statins are known for muscle soreness, leg cramps, etc. because they pull the water out of your muscles. I did what she said and didn’t have one issue. The only reason I am changing is because it made my liver enzymes shoot up.
I am at least going to give this script a chance, but I have already started taking my CO Q enzyme to help with my muscles. Fingers crossed. Read More Read Less

1

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Fill 3Created with Sketch. Condition: Stroke Prevention

Overall rating 2.0

EffectivenessEase of UseSatisfaction

this medicine changed my life (and not for the better). side effects included: total exhaustion, depression, joint aches, sexual dysfunction, mental fog, difficulty breathing, inability to climb stairs, leg weakness and buckling, etc. I went from being a distance swimmer and cyclist who, even though old, worked out everyday and pursued my profession as an artist to someone who could, literally, not get up from the couch. I spent last Winter just lying on the couch reading because I did not have the energy to do anything else. when I tried to go back to swimming, i found there was so much pressure on my chest that I couldn’t get my breath. I felt like my life was over for more than a year! I stopped taking this last week. Yesterday, I began to feel normal for the first time in more than a year. I will NEVER take another statin. I have alot of anger at the medical profession for not listening to patients when they report these side effects.Read More Read Less

2

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Fill 3Created with Sketch. Condition: High Cholesterol

Overall rating 1.7

EffectivenessEase of UseSatisfaction

Genetic high cholesterol. Resisted statin drugs for years and finally gave in to this one. I have been taking it for 2 months and I’m just now figuring out that the 15 lb weight gain in 11 days last month what’s most likely due to starting this drug. I am experiencing muscle pain and will be discontinuing this drug. I will get a cholesterol check in a few days to see if it has lowered any but the weight gain and muscle pain is never going to be worth it.

2

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Fill 3Created with Sketch. Condition: High Cholesterol

Overall rating 2.7

EffectivenessEase of UseSatisfaction

I was prescribed Pravastatin as I do not tolerate other statins. I began on 20mg then was put on 40mg. It brought my cholesterol down from the low 300’s to 212. I have hereditary high cholesterol. I experienced overwhelming, severe fatigue, bad sinus stuffiness and ear congestion and ear pain, very foggy memory, brain fog and extreme joint stiffness. I am in my 50’s and I feel like a 100 year old woman. I would wake up each morning feeling like dead weight and could barely move to get out of bed. Everything hurt. It is not helpful that I have no thyroid. I did a test and took myself off of Pravastatin for 2 weeks. My energy, ear/sinus pain, stiffness and brain fog all improved but my cholesterol went back up fast by about 30+ points. Crazy. I have had horrid reactions to other mainstream cholesterol meds. Livalo being the absolute worst. I almost went to the ER after being on that one for 6 days. I had awful bone and muscle pain and stiffness, felt like my sternum and ribs and chest would break if I moved the wrong way and I kept peeing dozens of times in one night and had severe low back pain. My body was trying to expel Livalo I’m sure.Read More Read Less

3

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Fill 3Created with Sketch. Condition: Changes Involving Fatty Deposits in the Blood Vessels

Overall rating 5.0

EffectivenessEase of UseSatisfaction

Halved my plasma cholesterol concentration after 1 year. Unfortunately, I have also lost a LOT of leg and arm muscle mass, but i don’t know if this was caused by this drug. I had to stop taking Lipitor due to muscle soreness and muscle loss. I began using statins in 2010 at age 64 and I am now 74.

2

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Fill 3Created with Sketch. Condition: High Cholesterol

Overall rating 1.7

EffectivenessEase of UseSatisfaction

3-4 weeks after taking 10 mg/day of this medication, I developed an itchy rash on my torso and scalp. Not worth it.

7

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Fill 3Created with Sketch. Condition: High Cholesterol

Overall rating 2.3

EffectivenessEase of UseSatisfaction

After one week I could easily sleep all day. It feels like all of the fluid has been drained from my back and legs. I just literally want to lay down all day and do nothing. I am usually very active but this has taken away any desire for me to workout since it feels like my legs are jello. Not sure what to do since I dont want to die of a heart attack like my family history has. Tough to lose weight since I dont want to hit the gym. Next step is to call my doctor and let her know but I have been on and off a few statins for the same reasons. They all do the same thing to me. Dang genetics. Oh to be healthy again. Read More Read Less

13

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Fill 3Created with Sketch. Condition: High Cholesterol

Overall rating 2.7

EffectivenessEase of UseSatisfaction

Terrible drug. Eventually I developed extreme muscle pain, itching skin, intestinal upset skin disruptions. Side effects not worth it. Don’t use this class of drug.

15

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IMPORTANT INFORMATION ABOUT USER-GENERATED CONTENT ON WEBMD

The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions.

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Effectiveness, Ease of Use, and Satisfaction

Show ratings & reviews for

2.9 Overall Rating

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Effectiveness

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Ease of Use

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Satisfaction

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Most voted positive review

62 People found this comment helpful

I have use Pravachol for over four years now. My total cholesterol lever has changed from 250 to 160. I have had no side effects from this drug.

Most voted negative review

10 People found this comment helpful

Provachol has been prescribed for me but I am afraid to take it because of the many side effects that all meds that are advertise have on your organs!!

Shared reviews and ratings

SORT BY Condition: Stroke Prevention

Overall rating 2. 3

EffectivenessEase of UseSatisfaction

This is my second try at Pravachor. I couldn’t tolerate another statin I had tried years before. My first Pravachor experience – diarrhea, flatulence, general fatigue. My second time around, several months later, my side effects are – so much fatigue I sit staring without even being able to think, I am taking several naps a day, I have walked an hour a day for years and now have to struggle to make 30 minutes because I have no energy, and expecially annoying is that I am having to get up ever 30 minutes to an hour to pee at night. The diarrhea has not started yet. I am not having any muscle pain. But how is being so fatigued I have no life and peeing so much I can’t sleep supposed to be good for me? I don’t know if I can keep this up. My doctor says keep taking it and “maybe the side effects will go away in 6 weeeks.” I don’t want to waste 6 weeks of my life. And no guarantee that the side effects will be gone. I think I would rather take my chances with higher cholesterol.Read More Read Less

1

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Fill 3Created with Sketch. Condition: Treatment to Prevent a Heart Attack

Overall rating 3.7

EffectivenessEase of UseSatisfaction

Been taking Pravastatin 40 mg for about 10 years now. Yeah, I notice some aches and pains here and there but none of us is getting younger. Nothing that has ever prevented me from living the life I want to live, which is moderately/average activity (i.e.: desk job but weekend warrior, camping, hunting, fishing, and having a few beers.) My only issue is that it’s become fairly ineffective at lowering my cholesterol, so my Doc bumped me up to 80mg. I could not tolerate the 80mg dose- after just 3 days, I was having that “out of body” feeling and falling asleep at my desk by 3pm every day. …so we went back to 40mg and all is well again..except my cholesterol numbers. So now they want me to start Crestor 20mg and I’m nervous about that, given that the reviews on Crestor make it seem like you’re signing your own death warrant. Read More Read Less

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Fill 3Created with Sketch. Condition: High Cholesterol

Overall rating 1.3

EffectivenessEase of UseSatisfaction

Prasavstatin 20 mg ..I do not recommend this to anyone ..it is pure poison..I spent over 4 years thinking that maybe it was normal to feel like I was in dreamland that my muscles would tense right up..vision was off kinda like a blur ..would have attacks cause my blood pressure would spike so low or very high..and doctors just said it was a panic attacks. ..just had blood work done cholesterol 7.8..not even working..my back was aching so bad I was always just in a hurry so I could go to sleep at night so I didn’t feel like that. .it’s a terrible feeling..Read More Read Less

1

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Fill 3Created with Sketch. Condition: Combined High Blood Cholesterol and Triglyceride Level

Overall rating 4.3

EffectivenessEase of UseSatisfaction

Tried Lipitor, Zocor, and Crestor. Lipitor was the worst; Crestor was more tolerable but still had side effects. So far so good with Pravachol — no side effects. Pravachol is the only statin not metabolized via the cytochrome P450 (CYP) system, so for those who have had issues with other statins it is worth at least giving Pravachol a try.

1

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Fill 3Created with Sketch. Condition: High Cholesterol

Overall rating 3.3

EffectivenessEase of UseSatisfaction

Yes it lowered my LDL and total cholesterol to 211 taking 20mg daily. Why only 20mg? Because at 40mg I suffered severe muscle and body aches. Pin prick sensations in my joints. Muscles felt so weak. Every day. I just couldn’t tolerate it. Still have some pain and weakness at 20mg. Trying to deal with it to get the benefits. But it’s hard. I tried another statin prior to Pravachol but had even worse side effects. Wish they would develop an affordable drug with the same benefits and not these side effects. Read More Read Less

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Fill 3Created with Sketch. Condition: Other

Overall rating 1.0

EffectivenessEase of UseSatisfaction

I was put on Pravastatin in order to reduce inflammation. I don’t have high cholesterol. My doctor felt it was safe. I was only on it for four days and I had a severe reaction. Brain fog with visual vertigo, leg cramping, diarrhea, constipation, severe burning sensation on my face that radiated through my body. I have been off of it nearly a week after only taking 4 10mg pills and I am still experiencing side effects. My doctor does not understand why I would still be experiencing side effects at this point. I do not recommend Pravastatin. Read More Read Less

1

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Fill 3Created with Sketch. Condition: Combined High Blood Cholesterol and Triglyceride Level

Overall rating 4.3

EffectivenessEase of UseSatisfaction

Headaches. Muscle pain. Leg weakness.

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Fill 3Created with Sketch. Condition: High Cholesterol

Overall rating 3.0

EffectivenessEase of UseSatisfaction

I have been taking 80 mg Pravachol for about two weeks now. So far, I have not experienced any of the side effects many people have reported. About its effectiveness, I have yet to find out in my next blood draw in a couple of months.

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Fill 3Created with Sketch. Condition: Combined High Blood Cholesterol and Triglyceride Level

Overall rating 1.7

EffectivenessEase of UseSatisfaction

muscle weakness dreadfull tried 4 statins all the same. try opti omega 3 ,plant sterols 3 a day, vitamink2 mk7,vitamin d ,my bones are repairing but not muscles. my cholesterol from 12.1 to 5.3 without statins. low fat diet and low sugar diet and herbal with no side effects

1

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Fill 3Created with Sketch. Condition: High Cholesterol

Overall rating 2. 7

EffectivenessEase of UseSatisfaction

My doctor switched me from simvistatin to pravastatin because of the muscle weakness. However the weakness and leg pain is alot worse so I can barely walk after 8 hrs of work. I have been off of all cholesterol meds for 4 weeks to clear up the side effects with no relief, just more pain. I wasnt aware of the chance that the side effects may never go away so now not only do I need to figure out how to keep my cholesterol down, but how to learn to live with muscle weakness and pain. If anyone is considering this medication I suggest using in the smallest dose possible to start with to minimize the side effects but I dont recommend this drug.Read More Read Less

16

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Fill 3Created with Sketch. Condition: High Cholesterol

Overall rating 2.3

EffectivenessEase of UseSatisfaction

I took them for about 3 months. I have always been relatively fit and coordinated person. I soon experienced severe muscle weakness, muscle pain, muscle wasting and brain fog. I literally had to sit down walking from the kitchen to the bedroom, but for a while, I did not realize why. When questioned, the doctor said, and I quote: “You are just going to have to find a way to deal with these side effects, ’cause you are going to be on them the rest of your life”. This statin induced muscle weakness resulted in two severe falls, a torn rotator cuff and a permanent dent in my skull!! I took myself off the statins, went on CoQ10. It took about 6 months for my strength to return. Please…..BE VERY CAREFUL with these statins. They were poison to my body. I wonder how many older Americans out there are feeling weak and are in pain due to these prescribed meds. Had my side effects not been as severe and come on so quickly, they may have been played off as simply getting old. Read More Read Less

27

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Fill 3Created with Sketch. Condition: High Cholesterol

Overall rating 2.3

EffectivenessEase of UseSatisfaction

I was taking another Crestor and it made my hips and shoulder joints ache. Took several months to make the connection. I stopped taking it and the joint pains got much better. Dr put me on generic Pravachol. Almost immediately the knee, joint, and should pain have returned, plus feeling generally lousy. Not positive this drug is the cause but I’m I’m going to stop taking it to see if I improve….again. PS it seems just recently statins are affecting me.

21

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Fill 3Created with Sketch. Condition: High Cholesterol

Overall rating 1.7

EffectivenessEase of UseSatisfaction

I took the generic RX of this drug,I had terrible pain in my hips and legs. While at the gym walking my legs gave out and I almost collapsed on the floor.It was aweful and no way Jose’ will I take this crap again!!!

25

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Overall rating 5.0

EffectivenessEase of UseSatisfaction

Switched from Lipitor after reading this drug reduces Diabetes risk up to 30% . Lipid levels need to be checked after two weeks.

4

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Fill 3Created with Sketch. Condition: Combined High Blood Cholesterol and Triglyceride Level

Overall rating 2.3

EffectivenessEase of UseSatisfaction

I took Pravastatin for about 2.5 years. It was moderately effective in keeping my cholesterol down–the main benefit was raising my “good” cholesterol and lowering the “bad. ” However, after about 2 years, I started having leg cramps during the night, and leg soreness during the day. It progressively got worse; like you had never exercised a day in your life and suddenly went out and ran a marathon! Talked to my pharmacist on a Friday, and she said stop taking it over the weekend and call the doctor at the first of the week. Well, by Monday or so, all the pain was gone. I quit taking it and refuse to take another statin drug.Read More Read Less

2

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Fill 3Created with Sketch. Condition: High Cholesterol

Overall rating 4.3

EffectivenessEase of UseSatisfaction

I have only been taking this drug for 4 months. It has lowered my overall cholesterol to about 90 and my LDL and HDL are all in satisfactory range. I have had absolutely no side effects thus far.

11

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Fill 3Created with Sketch. Condition: High Cholesterol

Overall rating 2.0

EffectivenessEase of UseSatisfaction

High level joint pains after only two weeks of use, fluid retention, feeling vague, inability to sleep, dark urine, feeling very tired, muscle weakness, reduced libido.

20

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Fill 3Created with Sketch. Condition: Combined High Blood Cholesterol and Triglyceride Level

Overall rating 5.0

EffectivenessEase of UseSatisfaction

My cholesterol is now 159 & Triglycerides are 180

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Fill 3Created with Sketch. Condition: Increased Triglycerides and Cholesterol

Overall rating 3. 0

EffectivenessEase of UseSatisfaction

Prescribed as a substitute when Lipitor caused aches and pains in sacrum and ilia. Stopping Lipitor for 2 weeks stopped the pain. (Just started taking Pravachol, so star ratings above are there just because they are required.)

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Fill 3Created with Sketch. Condition: High Cholesterol

Overall rating 3.7

EffectivenessEase of UseSatisfaction

After being on this drug for 3 years ive noticed the last 2 years i hurt all the time and its all muscle pain. Its effecting my spine now and I went to dr last nite and he thinks its this med. I will be calling my dr on monday escially after reading all these review. Think its time to come off.

20

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IMPORTANT INFORMATION ABOUT USER-GENERATED CONTENT ON WEBMD

The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions.

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08/04/2022 11:30

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Millions of people take statins to lower their levels cholesterol. And many of them experience agonizing side effects: muscle pain and cramps; weakness that grows every day – such that the legs do not hold, and there is no strength to rise; liver damage; increased risk of developing diabetes – and this is not the whole list. In August 2001, a well-known pharmaceutical company was forced to recall a popular cholesterol-lowering drug that about 700,000 Americans were taking after 31 people died from severe myopathy – progressive muscle atrophy 1 .

Evalar press service

But you can’t cancel the statins prescribed by your doctor! They must be taken constantly, often for life. Therefore, the question arises: is it possible to somehow neutralize their dangerous side effects?

Scientists have found that simultaneously with lowering cholesterol, statins also lower the level of coenzyme Q 10 in the body – after a month of taking statins, it drops by 50-80% 2 ! With such a sharp decrease in the level of coenzyme, the body begins to age prematurely, wither, weaken, become infirm. In the United States, when prescribing statins, more and more experts recommend taking coenzyme Q 9 concomitantly with statins.0031 10 3 . It is necessary for our muscles as a source of intracellular energy, which allows us to maintain motor activity, and especially for the main muscle – our heart, which simply cannot work without it. Daily intake of 100 mg of coenzyme Q 10 has been shown to significantly reduce the severity of muscle pain 2 and neutralize other changes associated with the side effects of statins 4 . Moreover, the use of coenzyme Q 10 for the prevention and treatment of heart failure reduces the number of hospitalizations by 38% 5 .

On the shelves of pharmacies you can find a variety of types and forms of coenzyme – tablets, water-based drops, suspensions, etc. But we must remember that coenzyme Q 10 is a fat-soluble substance, that is, it is absorbed as much as possible in the form of an oil solution. Therefore, carefully read the composition on the package – oil should come first. Soybean is most often used – it is cheap and has an unpleasant aftertaste; slightly less – olive.

But the company “Evalar” for better assimilation of its Coenzyme Q 10 chose not just any oil, but coconut oil, which in itself is just a storehouse of nutrients necessary for our body. Each capsule of Coenzyme Q 10 Evalar contains the maximum 6 dosage of coenzyme (100 mg) dissolved in first cold pressed coconut oil from a leading manufacturer in Japan. At the same time, Coenzyme Q 10 Evalar is 2 times more profitable than its analogue 7 !

Coenzyme Q 10 Evalar can be taken not only to reduce the side effects of statins – it contributes to:

  • strengthen the heart muscle;
  • preservation of youth and beauty
  • slowing down the aging process.

You can buy Coenzyme Q10 Evalar on the website evalar.ru, fitomarket.ru, and apteka.ru, as well as in pharmacies in your city.

dietary supplement. It is not a medicine. Consult a specialist before use.

Photo: Evalar press service

1. https://info-farm.ru/alphabet_index/c/cerivastatin.html

2. Atmosphere. Cardiology. 2008, No. 3

3. Nutrition Journal. 2013, no. 12: p. 142

4. Alternative and Complementary Therapies VOL. 9, No. 4

5. Morisco C., Trimarco B., Condorelli M. Effect of coenzyme Q10 therapy in patients with congestive heart failure: a long-term multicenter randomized study. Clin Investig 1993;71(suppl 8):S134-S136.

6. Available in Evalar

7. Benefit in terms of price according to JSC “DSM Group” for the 1st half of 2019

Content

  • Structural formula

  • Russian name

  • English name

  • Latin name

  • chemical name

  • Gross formula

  • Pharmacological group of the substance Pravastatin

  • Nosological classification

  • CAS code

  • pharmachologic effect

  • Characteristic

  • Pharmacology

  • The use of the substance Pravastatin

  • Contraindications

  • Use during pregnancy and lactation

  • Side effects of Pravastatin

  • Interaction

  • Overdose

  • Dosage and administration

  • Trade names with the active substance Pravastatin

Structural formula

Russian name

Pravastatin

English name

Pravastatin

Latin name

Pravastatinum (born 9 0180 Pravastatini)

Chemical name

1,2,6,7,8,8a- Hexahydro-beta, delta, 6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-1-naphthaleneheptanoic acid (and as sodium salt)

Gross formula

C 23 H 36 O 7

Pharmacological group of the substance Pravastatin

Statins

Nosological classification

ICD-10 code list

  • E78. 2 Mixed hyperlipidemia

  • E78.5 Hyperlipidemia, unspecified

  • I25 Chronic ischemic heart disease

CAS code

81093-37-0

Pharmacological action

Pharmacological action –

hypolipidemic .

Characteristics

Odorless white or colorless crystalline powder. Let’s well dissolve in water, we will badly dissolve in isopropanol and practically insoluble in acetone, acetonitrile and chloroform.

Pharmacology

Inhibits HMG CoA reductase, therefore inhibits the corresponding stage of cholesterol biosynthesis in the liver, reduces the intracellular pool of cholesterol, increases the metabolism and clearance of LDL and inhibits the formation of VLDL (LDL precursors) in the liver.

Absorbed up to 54% when administered orally (taken 1 hour before or with food reduces systemic bioavailability and specific activity). It is subjected to significant binding by hepatocytes after the “first pass” through the liver. max”>C max is achieved in 1–1.5 hours. It binds to plasma proteins by 50%. Biotransformation is carried out in several ways: isomerization to 6-epipravastatin and 3-hydroxyisomer, enzymatic hydroxylation of the ring and subsequent oxidation to ketone, oxidation of the ether or carboxyl ends of the chain, conjugation; the main metabolic products – 3-hydroxyisomers – have a specific activity ranging from 1/14 to 1/10 of the original. T 1/2 for pravastatin and its metabolites is 77 hours. About 20% of the orally administered dose is excreted in the urine and 70% in the faeces, approximately 47% of the total Cl is in the kidneys and 53% in the extrarenal routes (i.e. e. biliary and biotransformational). Due to the presence of two routes of excretion, a compensatory increase in the elimination of one of them is possible in case of violation of the other, as well as the development of cumulation of pravastatin and its metabolites in case of impaired liver and / or kidney function.

The use of the substance Pravastatin

Hyperlipidemia without CAD (reducing the risk of myocardial infarction), atherosclerosis and CAD, including myocardial infarction (to slow the progression of atherosclerosis and reduce the likelihood of a second heart attack), type II hyperlipidemia (increased LDL, VLDL, total cholesterol), familial hypercholesterolemia (in patients with a transplanted heart to reduce the likelihood of developing coronary angiopathy).

Contraindications

Hypersensitivity, liver disease and / or violation of its functions, pregnancy, lactation, children, adolescents and young adults (up to 18 years).

Use in pregnancy and lactation

Contraindicated in pregnancy.

FDA fetal category X.

Stop breastfeeding during treatment.

Side effects of the substance Pravastatin

Cranial nerve dysfunction (taste disturbance, involuntary eye movements, facial nerve paresis), tremor, dizziness, anxiety, insomnia, depression, amnesia, paresthesia, peripheral polyneuropathies, pancreatitis, hepatitis (including chronic active and cholestatic), fatty infiltration, cirrhosis or necrosis of the liver, hepatoma, anorexia, nausea, myopathy, arthralgia, acute renal failure against the background of rhabdomyolysis, gynecomastia, decreased libido and potency, cataract progression, ophthalmoplegia, alopecia, skin nodulation and dispigmentation, dry skin and mucous membranes, respiratory disorders, toxic epidermal necrosis, erythema multiforme, Stevens-Johnson syndrome, increased plasma concentrations of AST and ALT (2-3 times compared with the norm), creatine phosphokinase (CPK), alkaline phosphatase, bilirubin, photosensitivity, allergic reactions (anaphylactic shock, angioedema, lupus-like syndrome, rheumatoid polyalgia, dermatomyositis, vasculitis, purpura, thrombocytopenia, leukopenia, hemolytic anemia, eosinophilia, arthritis, urticaria).