What are the primary uses of Preparation H suppositories. How should they be properly administered. What are the potential side effects and precautions to consider. When should you consult a healthcare professional while using Preparation H suppositories.

Understanding Preparation H Suppositories: Composition and Purpose

Preparation H suppositories are a well-known over-the-counter medication designed to alleviate hemorrhoid symptoms. These suppositories contain two primary active ingredients: phenylephrine and cocoa butter. Phenylephrine acts as a vasoconstrictor, helping to reduce swelling and inflammation in the rectal area, while cocoa butter provides a soothing, lubricating effect.

The primary purpose of Preparation H suppositories is to provide relief from various symptoms associated with hemorrhoids, including:

• Itching and irritation in the rectal area
• Swelling and inflammation
• Discomfort during bowel movements
• Minor bleeding associated with hemorrhoids

Are Preparation H suppositories suitable for all types of hemorrhoids? While they can be effective for many cases, it’s important to note that severe or persistent hemorrhoids may require more advanced treatment options. Always consult with a healthcare professional if symptoms persist or worsen despite using over-the-counter remedies.

Proper Usage and Administration of Preparation H Suppositories

To maximize the effectiveness of Preparation H suppositories and minimize potential side effects, it’s crucial to use them correctly. Here’s a step-by-step guide on how to properly administer these suppositories:

1. Clean the affected area gently with mild soap and water, then pat dry.
2. Remove the suppository from its wrapper and moisten it slightly with water to aid insertion.
3. Lie on your left side with your right knee bent.
4. Carefully insert the suppository into the rectum, pointed end first, using your finger.
5. Remain lying down for a few minutes to allow the suppository to melt and be absorbed.
6. Avoid having a bowel movement for at least an hour after insertion.

How often should Preparation H suppositories be used? Generally, they can be used up to four times daily, typically once in the morning, once in the evening, and after each bowel movement. However, it’s essential to follow the instructions on the product package or your healthcare provider’s recommendations.

Potential Side Effects and Adverse Reactions

While Preparation H suppositories are generally well-tolerated when used as directed, some individuals may experience side effects. It’s important to be aware of these potential reactions and know when to seek medical attention.

Common Side Effects

The most frequently reported side effects of Preparation H suppositories include:

• Mild pain or stinging sensation upon application, especially if the rectal tissue is raw or bleeding
• Temporary discomfort or burning feeling
• Itching or irritation at the application site

These side effects are usually mild and transient. However, if they persist or worsen, it’s advisable to discontinue use and consult a healthcare professional.

Serious Side Effects

While rare, some users may experience more severe side effects that require immediate medical attention. These can include:

• Fast or irregular heartbeat
• Pounding headache
• Nervousness or anxiety
• Tremors or shakiness
• Insomnia or difficulty sleeping
• Signs of an allergic reaction (rash, itching, swelling, severe dizziness, trouble breathing)

Can Preparation H suppositories cause systemic effects? While the medication is intended for local use, the active ingredient phenylephrine can potentially be absorbed into the bloodstream, leading to systemic effects in some individuals. This is why it’s crucial to use the product as directed and be vigilant for any unusual symptoms.

Precautions and Contraindications for Preparation H Suppositories

Before using Preparation H suppositories, it’s essential to consider certain precautions and potential contraindications to ensure safe and effective use.

Medical Conditions to Consider

Individuals with the following health conditions should consult their healthcare provider before using Preparation H suppositories:

• Diabetes
• Heart problems (e.g., chest pain, history of heart attack)
• High blood pressure
• Overactive thyroid (hyperthyroidism)
• Difficulty urinating due to prostate enlargement or other blockages

Why is it important to disclose these conditions to a healthcare provider? These medical conditions can potentially interact with the active ingredients in Preparation H suppositories, leading to adverse effects or complications.

Pregnancy and Breastfeeding

Pregnant women should use Preparation H suppositories only when clearly necessary and after consulting with their healthcare provider. The risks and benefits should be carefully weighed, as the effects on fetal development are not fully known.

For breastfeeding mothers, it’s unclear whether the active ingredients in Preparation H suppositories pass into breast milk. As a precaution, it’s advisable to consult a healthcare provider before using this product while breastfeeding.

Drug Interactions and Compatibility Concerns

Preparation H suppositories can potentially interact with other medications, altering their effectiveness or increasing the risk of side effects. It’s crucial to be aware of these potential interactions and discuss them with a healthcare provider or pharmacist.

Medications That May Interact

Some medications that may interact with Preparation H suppositories include:

• MAO inhibitors (e.g., isocarboxazid, linezolid, phenelzine)
• Blood pressure medications (e.g., guanethidine, beta-blockers like metoprolol)
• Certain cough and cold medications
• Diet aids containing stimulants

Why is it important to inform healthcare providers about all medications being taken? Some combinations can lead to dangerous increases in blood pressure or heart rate, while others may reduce the effectiveness of either medication.

Over-the-Counter Products

It’s not just prescription medications that can interact with Preparation H suppositories. Some over-the-counter products, particularly those containing stimulants or decongestants, may also pose risks when used concurrently.

To ensure safety, always inform your healthcare provider or pharmacist about all products you’re using, including prescription medications, over-the-counter drugs, and herbal supplements.

When to Seek Medical Attention

While Preparation H suppositories can effectively manage many cases of hemorrhoids, there are situations where professional medical evaluation is necessary. Recognizing these signs is crucial for preventing complications and ensuring appropriate treatment.

Preparation H (phenylephrine,cocoa butter) rectal: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

How to use Preparation H Suppository, Rectal

Follow all directions on the product package. If you have any questions, ask your doctor or pharmacist.

Before use, clean the area with mild soap and water, rinse well, and pat dry.

Use this product in the rectum only. This product is generally used up to 4 times a day, usually one in the morning and one in the evening, and after each bowel movement or as directed by your doctor.

Unwrap the suppository and moisten it with a few drops of water to soften it. Lie on your left side with the right knee bent. Carefully push the suppository (pointed end first) just inside the rectum with your finger. Remain lying down for a few minutes, and avoid having a bowel movement for at least 1 hour.

Dosage is based on your medical condition and response to treatment. Do not use more often or for a longer time than directed.

If symptoms do not improve within 7 days, if bleeding/worsening pain occurs, or if you think you may have a serious medical problem, consult your doctor promptly.

Side Effects

This medication does not usually have bothersome side effects when used as directed. Mild pain/stinging may occur if the rectal tissue is raw or bleeding. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

If your doctor has directed you to use this medication, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Stop using this medication and tell your doctor right away if you have any serious side effects, including: fast/irregular heartbeat, pounding headache, nervousness, shakiness (tremor), trouble sleeping.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before using this product, tell your doctor or pharmacist if you are allergic to it; or to any of its ingredients; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

If you have any of the following health problems, consult your doctor or pharmacist before using this product: diabetes, heart problems (such as chest pain, heart attack), high blood pressure, overactive thyroid (hyperthyroidism), difficult urination due to blockage (for example, due to an enlarged prostate).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

Consult your pharmacist or physician.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Some products that may interact with this drug are: MAO inhibitors (isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine), drugs to treat high blood pressure (including guanethidine, beta blockers such as metoprolol).

Some products have ingredients that could raise your heart rate or blood pressure. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products or diet aids).

Does Preparation H Suppository, Rectal interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

This medicine may be harmful if swallowed. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

To maintain normal bowel function and reduce the risk of hemorrhoids, eat a proper diet high in fiber, drink 6 to 8 glasses of water each day, and exercise regularly.

If you are using this product on a regular schedule and miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature. Different brands of this medication may have different storage needs. Check the product package for instructions on how to store your brand, or ask your pharmacist. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Images

Preparation H(phenyleph,cocoa buttr) 0.25 %-88.44 % rectal suppository

Color: yellowShape: bulletImprint:

This medicine is a yellow, bullet, suppos

Look up another drug

Find other drugs that treat your condition

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Preparation H rectal: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

How to use Preparation H Suppository

Follow all directions on the product package. If you have any questions, ask your doctor or pharmacist.

Before use, clean the area with mild soap and water, rinse well, and pat dry. Use this product in the rectum only.

This product is generally used up to 6 times a day, or after each bowel movement, or as directed by your doctor. Dosage is based on your medical condition and response to treatment. Do not use more often or for a longer time than directed.

To use suppositories, unwrap the suppository. Lie on your left side with the right knee bent. Carefully push the suppository (pointed side first) just inside the anus with your finger. Do not push more than an inch or two inside the anus.

If the suppository is too soft to insert, place it in cold water or refrigerate it for 30 minutes before removing the wrapper.

Do not use this medication if hemorrhoids are bleeding or the rectal area is raw and irritated.

If symptoms do not improve within 7 days, if bleeding/worsening pain occurs, or if you think you may have a serious medical problem, tell your doctor promptly.

Side Effects

This medication does not usually have bothersome side effects when used as directed. If symptoms do not improve within 7 days, or if bleeding, pain, or irritation occur, tell your doctor promptly.

If your doctor has directed you to use this medication, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before using this product, tell your doctor or pharmacist if you are allergic to any of its ingredients, or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this medication passes into breast milk. However, it is unlikely to pass into breast milk or to harm a nursing infant. Consult your doctor before breast-feeding.

Consult your pharmacist or physician.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Does Preparation H Suppository interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

This medicine may be harmful if swallowed. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

To maintain normal bowel function and reduce the risk of hemorrhoids, eat a proper diet high in fiber, drink 6 to 8 glasses of water each day, and exercise regularly.

If you are using this product on a regular schedule and miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature. Different brands of this medication may have different storage needs. Check the product package for instructions on how to store your brand, or ask your pharmacist. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Images

Look up another drug

Find other drugs that treat your condition

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Instructions – Genferon Light suppositories

Immunobiological properties

GENFERON ^® LITE 125 thousand IU is a combination drug, the action of which is due to the components that make up its composition. It has a local and systemic effect.

GENFERON ^® LITE 125 thousand IU contains recombinant human interferon alfa-2b, produced by a strain of Escherichia coli bacterium, into which the human interferon alfa-2b gene has been introduced by genetic engineering.

Interferon alfa-2b has antiviral, immunomodulatory, antiproliferative and antibacterial effects. The antiviral effect is mediated by the activation of a number of intracellular enzymes that inhibit viral replication. The immunomodulatory effect is manifested primarily by an increase in cell-mediated reactions of the immune system, which increases the effectiveness of the immune response against viruses, intracellular parasites and cells that have undergone tumor transformation. This is achieved by activating CD8+ T-killers, NK-cells (natural killers), enhancing the differentiation of B-lymphocytes and their production of antibodies, activating the monocyte-macrophage system and phagocytosis, as well as increasing the expression of molecules of the major histocompatibility complex type I, which increases the likelihood of recognition of infected cells by cells of the immune system. Activation under the influence of interferon of leukocytes contained in all layers of the mucous membrane ensures their active participation in the elimination of pathological foci; in addition, due to the influence of interferon, restoration of the production of secretory immunoglobulin A is achieved. The antibacterial effect is mediated by reactions of the immune system, enhanced by interferon.

Taurine contributes to the normalization of metabolic processes and tissue regeneration, has a membrane-stabilizing and immunomodulating effect. Being a strong antioxidant, taurine directly interacts with reactive oxygen species, the excess accumulation of which contributes to the development of pathological processes. Taurine helps to preserve the biological activity of interferon, enhancing the therapeutic effect of the drug.

Pharmacokinetics

With rectal administration of the drug, high bioavailability (more than 80%) of interferon is noted, in connection with which both local and pronounced systemic immunomodulatory effects are achieved; with intravaginal use, due to the high concentration in the focus of infection and fixation on the cells of the mucous membrane, a pronounced local antiviral, antiproliferative and antibacterial effect is achieved, while the systemic effect due to the low absorption capacity of the vaginal mucosa is insignificant. The maximum concentration of interferon in the blood serum is reached 5 hours after the administration of the drug. The main route of excretion of α-interferon is renal catabolism. The half-life is 12 hours, which necessitates the use of the drug 2 times a day.

Indications for use

– As a component of complex therapy – for the treatment of acute respiratory viral infections and other infectious diseases of bacterial and viral etiology in children.

– As a component of complex therapy – for the treatment and prevention of repeated episodes of acute respiratory viral infections in frequently and long-term ill children aged 3 to 6 years.

– For the treatment of infectious and inflammatory diseases of the urogenital tract in children.

Dosage and administration

The drug can be used both vaginally and rectally. In children under 7 years of age, including infants, it is safe to use the drug at a dose of 125,000 IU of interferon alfa-2b per suppository.

Recommended doses and treatment regimens:

Acute respiratory viral infections and other acute viral diseases in children: 1 suppository rectally 2 times a day with a 12-hour interval parallel to the main therapy for 5 days. If, after a 5-day period of treatment, the symptoms of the disease do not decrease or become more pronounced, the patient should consult a doctor. According to clinical indications, it is possible to repeat the course of treatment after a 5-day interval.

Acute respiratory viral infections in frequently and long-term ill children aged 3 to 6 years: 1 suppository (125,000 IU) rectally 2 times a day with an interval of 12 hours for 10 days in parallel with standard therapy. After the completion of the main period of treatment of acute respiratory viral infection, it is possible to switch to a prophylactic regimen: 1 suppository (125,000 IU) rectally 1 time at night every other day for 3 weeks.

Acute infectious and inflammatory diseases of the urogenital tract in children: 1 suppository rectally 2 times a day with a 12-hour interval for 10 days against the background of specific therapy prescribed and controlled by a doctor.

Side effects

The drug is well tolerated by patients. Very rare (frequency less than 1 in 10,000 cases): there are isolated reports of cases of allergic reactions. These phenomena are reversible and disappear within 72 hours after cessation of administration. Continuation of treatment is possible after consultation with a doctor.

No severe or life-threatening side effects have been observed to date.

Contraindications

Individual intolerance to interferon and other substances that make up the drug.

Precautions

Aggravation of allergic and autoimmune diseases.

Use during pregnancy and lactation

Not used.

Interaction with other drugs

GENFERON ^® LITE 125 thousand IU is most effective as a component of complex therapy. When combined with antibacterial, fungicidal and antiviral drugs, mutual potentiation of action is observed, which makes it possible to achieve a high total therapeutic effect.

Overdose

Cases of overdose of GENFERON ^® LITE 125 thousand IU have not been registered. In case of accidental simultaneous administration of more suppositories than prescribed by the doctor, further administration should be suspended for 24 hours, after which treatment can be resumed according to the prescribed scheme.

Special instructions

GENFERON ^® LITE 125 thousand IU does not affect the performance of potentially hazardous activities that require special attention and quick reactions (driving vehicles, machinery, etc.).

Storage and transport conditions

At temperatures from 2 to 8 ⁰ C.
Keep out of the reach of children.

Product form

Vaginal and rectal suppositories 125,000 IU + 5 mg.

5 suppositories in a blister pack made of aluminum foil with a polyethylene backing. 2 blister packs together with instructions for use in a cardboard pack.

Shelf life

2 years.
Do not use after the expiry date which is stated on the pack.

Terms of dispensing from pharmacies

Available without a prescription – vaginal and rectal suppositories 125,000 IU + 5 mg.

Marketing authorization holder

BIOCAD JSC, Russia, 198515, St. Petersburg, int.ter.g. settlement of Strelna, settlement of Strelna, st. Communications, 38, building 1, room 89

Krasnogorsk, with. Petrovo-Far, st. Promyshlennaya, d. 5, building 2.

Organization accepting consumer claims

BIOCAD JSC, Russia, 198515, St. settlement of Strelna, settlement of Strelna, st. Communications, 38, building 1, room 89
Tel.: +7 (812) 380 4933,
Fax: +7 (812) 380 49 34
e-mail: [email protected]
Send information about the development of adverse reactions to: [email protected]

instructions for use, what helps, indications, dosage, composition

• 90 004 Dosage form

  Vaginal suppositories

• Release form

  Suppositories vaginal 100 mg.

  5 suppositories in a blister pack made of polyvinyl chloride film laminated with polyethylene.

  1 or 2 blister packs together with instructions for medical use of the medicinal product in a cardboard pack.

• Composition

  One suppository contains:

  Active ingredients: lactic acid – 100 mg;

  Excipients: macrogol mixture:
  macrogol 1500 – (92 – 98)%, macrogol 400 – (8 – 2)%.

• Description

  Torpedo-shaped suppositories white or white with grayish or
  yellowish tinge of color. Marbling and the presence of an air rod and a funnel-shaped recess on the cut are allowed.

• Pharmacotherapeutic group

  Antiseptic

• Pharmacological properties

  Lactic acid is a natural product of the vital activity of the lactic acid bacteria of the vagina, provides a pH of the vaginal secretion in the range of 3.5-4.5. Suppositories with lactic acid help to restore and maintain normal pH and vaginal flora, suppress the growth of acid-sensitive pathogenic and conditionally pathogenic flora.

  Lactic acid creates an acid reserve to correct the pH shift to the alkaline side observed in vaginal infections. Helps to increase the natural protection of the vagina against genital infections.

• Indications for use

  Normalization of disturbed microflora and pH of the vagina, including bacterial vaginosis (as part of complex therapy).

• Contraindications

  Hypersensitivity to the components of the drug, vulvovaginal candidiasis, children’s age (up to 18 years).

• Pregnancy and breastfeeding

  Special studies of the drug Lactodepantol during pregnancy and during breastfeeding have not been conducted. In studies conducted in animals, there were no signs of the toxic effect of lactic acid on the fetus. In clinical studies of lactic acid in various dosage forms for intravaginal administration, safety problems have not been identified.

  Given the fact that lactic acid is an intermediate product of mammalian metabolism and is normally found in the human body, including in amniotic fluid, breast milk, the use of the drug Lactodepantol during pregnancy and breastfeeding is possible after assessing the potential benefit to the mother and the risk to the fetus and infant who is breastfed. Before use, you should consult with your doctor.

• The ability to influence the reaction rate when driving motor vehicles or operating other mechanisms

  The use of the drug does not affect the ability to drive vehicles, work with mechanisms.

• Dosage and Administration

  Intravaginally. Before using the suppository
  exempt from contour packaging.

  One vaginal suppository is inserted into the vagina (lying on the back with legs slightly bent) once a day. The course of treatment is 10 days.

  If there is no improvement after treatment,
  or new symptoms appear, you should consult your doctor.

  Use the drug only according to the indication, the method of application
  and in those doses indicated in the instructions.

• Overdose

  No cases of drug overdose have been reported.

• Side effect

  Possible allergic reactions, itching, in isolated cases – burning in the vagina, passing after discontinuation of the drug.