About all

Protonix uses and side effects: Protonix Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Protonix Interactions Checker – Drugs.com



There are 163 drugs known to interact with
Protonix (pantoprazole), along with
4 disease interactions.

Of the total drug interactions,
16 are major, 128 are moderate, and 19 are minor.

Does Protonix interact with my other drugs?

Enter other medications to view a detailed report.

  • View all 163 medications that may interact with Protonix
  • View Protonix disease interactions (4)

Most frequently checked interactions

View interaction reports for Protonix (pantoprazole) and the medicines listed below.

  • Major
  • Moderate
  • Minor
  • Unknown
  • albuterol
  • amlodipine
  • aspirin
  • atorvastatin
  • Cymbalta (duloxetine)
  • folic acid
  • gabapentin
  • Lasix (furosemide)
  • levothyroxine
  • Lexapro (escitalopram)
  • Lipitor (atorvastatin)
  • lisinopril
  • losartan
  • Lyrica (pregabalin)
  • metformin
  • metoprolol
  • Plavix (clopidogrel)
  • potassium chloride
  • prednisone
  • Singulair (montelukast)
  • Synthroid (levothyroxine)
  • tramadol
  • trazodone
  • Tylenol (acetaminophen)
  • Vitamin B12 (cyanocobalamin)
  • Vitamin D3 (cholecalciferol)
  • Xanax (alprazolam)
  • Zofran (ondansetron)
  • Zoloft (sertraline)
  • Zyrtec (cetirizine)

Protonix disease interactions

There are 4 disease interactions with Protonix (pantoprazole) which include:

  • C. diff
  • liver disease
  • bone fractures
  • hypomagnesemia

Report options


QR code containing a link to this page

More about Protonix (pantoprazole)

  • Protonix consumer information
  • Compare alternatives
  • Pricing & coupons
  • Reviews (80)
  • Drug images
  • Side effects
  • Dosage information
  • Patient tips
  • During pregnancy
  • Generic availability
  • Support group
  • Drug class: proton pump inhibitors
  • Breastfeeding
  • En español

Related treatment guides

  • Erosive Esophagitis
  • Barrett’s Esophagus
  • Duodenal Ulcer
  • GERD

Drug Interaction Classification
These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
MajorHighly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
ModerateModerately clinically significant. Usually avoid combinations; use it only under special circumstances.
MinorMinimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
UnknownNo interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Protonix Reviews & Ratings – Drugs.com



has an average rating of 7.1 out of 10 from a total of 78 reviews
on Drugs. com.
64% of reviewers reported a positive experience, while 23% reported a negative experience.

Condition Avg. Rating ReviewsCompare
GERD  50 reviews for GERD227 medications
Stomach Ulcer  9 reviews for Stomach Ulcer100 medications
Barrett’s Esophagus  7 reviews for Barrett’s Esophagus13 medications
Erosive Esophagitis  6 reviews for Erosive Esophagitis103 medications
Duodenal Ulcer  3 reviews for Duodenal Ulcer131 medications
Peptic Ulcer  3 reviews for Peptic Ulcer47 medications
Add your review

Reviews for Protonix

Frequently asked questions

  • Pantoprazole vs. omeprazole: What’s the difference between them?
  • Can you take pantoprazole 40 mg twice a day?
  • What are the risks associated with heartburn medications?
  • How long can I take pantoprazole?

Are you taking this medicine?

  • Add your review
  • Learn more about Protonix

More FAQ

  • Does pantoprazole cause bloating?

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.

More about Protonix (pantoprazole)

  • Check interactions
  • Compare alternatives
  • Pricing & coupons
  • Drug images
  • Side effects
  • Dosage information
  • Patient tips
  • During pregnancy
  • Generic availability
  • Support group
  • Drug class: proton pump inhibitors
  • Breastfeeding
  • En español

Patient resources

  • Drug Information
  • Protonix oral/injection
  • Protonix (Pantoprazole Intravenous) (Advanced Reading)
  • Protonix (Pantoprazole Oral) (Advanced Reading)
  • Protonix (Pantoprazole Delayed-Release Granules)
  • Protonix (Pantoprazole Delayed-Release Tablets)

Professional resources

  • Prescribing Information

Other formulations

  • Protonix IV

Related treatment guides

  • Erosive Esophagitis
  • Barrett’s Esophagus
  • Duodenal Ulcer
  • GERD

Protonix Tablet English – Product

Protonix Tablet English – Product – TabletWise. com

About Us

  • About Us
  • Privacy Policy
  • Instructions for Use

  • Overview
  • Benefits
  • Side Effects
  • Precautions
  • 900 06 Interaction

  • Contraindications


Protonix Tablet is used for Gastroesophageal reflux disease and other conditions.

Protonix Tablet contains Pantoprazole Sodium as an active ingredient. Available in tablet form.

Detailed information regarding the use, composition, dosage, side effects of Protonix Tablet / Protonix Tablet, as well as user reviews are provided below:


Protonix Tablet is used for the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms: 4


The following is a list of possible side-effects that may occur from all constituents of Protonix Tablet. This list is not final. These side effects have been recorded previously, but are not always recorded when using the drug. Some of these side effects may be extremely rare, but have incredibly severe consequences. If you notice any side effects, contact your doctor immediately. Especially in the case of observing side effects for a long time.

  • Constipation
  • Headache
  • Nausea
  • Vomiting
  • Gas
  • Joint pain
  • Constipation

90 003 If you experience side effects not listed above, contact your healthcare provider for advice. In addition, you can report side effects to your local Food and Drug Administration.


Before starting this drug, tell your doctor about any medications you are taking, nutritional supplements (eg vitamins, natural supplements, etc.), allergies, existing medical conditions, and current health conditions (eg, pregnancy, upcoming surgery, etc. ). The side effects of the drug may be more pronounced depending on the condition of your body. Take this medicine as directed by your doctor, or follow the directions for use that come with your medicine. The dosage of the drug depends on your condition. Tell your doctor if there is no change or if your condition worsens. Important points to discuss with your healthcare provider are listed below.

  • Breastfeeding
  • Low blood magnesium
  • Plan to get pregnant
  • pregnant

Tablet / Protonix Tablet is subject to change. Tell your healthcare provider about all medications, vitamins, and supplements you use. Your doctor will be able to make the right plan for taking the drug, which will avoid negative interactions. Protonix Tablet may interact with the following drugs and products:

  • Ampicillin
  • Atazanavir
  • Dexlansoprazole
  • Digoxin
  • Esomeprazole
  • Ketoconazole
  • Lansoprazole 90 008
  • Methotrexate
  • Nelfinavir
  • Omeprazole

Hypersensitivity to Protonix Tablet is a contraindication. In addition, Protonix Tablet should not be used if you have the following conditions:

  • Allergic reaction

Composition and active ingredients

Protonix Tablet is composed of the following active ingredients (salts)

  • Pantoprazole Sodium attention to the fact that this drug is available with different strengths of intensity for each of the active ingredients listed above.

    Packing Options and Strengths

    Protonix Tablet is available in the following packages and strengths

    Protonix Tablet packages available: EQ 40MG BASE, EQ 20MG BASE


    • Is it safe to drive or operate heavy machinery while using this product?

      If you experience drowsiness, dizziness, hypotension or a headache as side-effects when using Protonix Tablet medicine then it may not be safe to drive a vehicle or operate heavy machinery. You should stop driving if taking this medicine makes you drowsy, dizzy, or hypotensive. Doctors recommend that you stop drinking alcohol with such drugs, because. alcohol greatly increases the side effects and drowsiness. Please check for these effects on your body when using Protonix Tablet. Be sure to consult your doctor for advice based on the characteristics of your body and general health.

    • Is this drug (product) addictive or addictive?

      Most drugs are not habit-forming or addictive. In most cases, the state classifies drugs that can be addictive as controlled dispensing drugs. For example, schedule H or X in India and schedule II-V in the USA. Please check the information on the drug packaging to make sure that this drug is not in the controlled category. Also, do not self-medicate or accustom your body to medications without consulting your doctor.

    • Can I stop using this product immediately or do I need to slowly stop using it?

      Some medications need to be stopped gradually due to a rebound effect. Be sure to consult your healthcare provider for advice based on your body, general health, and other medications you may be taking.

    Cite this page

    Page URL

    HTML Link

    Protonix Tablet

    APA Style Citation
    • Protonix Tablet – Product – TabletWise.com. (n.d.). Retrieved May 03, 2023, from https://www.tabletwise.com/us-ru/protonix-tablet
    MLA Style Citation
    • “Protonix Tablet in English – Product – TabletWise.com” Tabletwise.com . N.p., n.d. Web. May 03 2023.
    Chicago Style Citation
    • “Protonix Tablet in English – Product – TabletWise.com” Tabletwise. Accessed May 03, 2023. https://www.tabletwise.com/us-ru/protonix-tablet.

    More information about Protonix Tablet

    • Uses of
    • Reviews
    • What are the uses of Protonix Tablet?
    • What are the side effects of Protonix Tablet?
    • What other medicines does Protonix Tablet interact with?
    • When should you not use Protonix Tablet?
    • What precautions should you take while using Protonix Tablet?

    Last updated date

    This page was updated on 9/28/2020.

    This page provides information for Protonix Tablet Product in English .

    Share with friends, get 20% off

    Invite your friends to TabletWise learning marketplace. For each purchase they make, you get 20% off (upto $10) on your next purchase.

    Protonix I.V. – instructions for use, dosage, composition, analogs, side effects / Pillintrip


    Included as part of PRECAUTIONS section.


    Sequelae of symptomatic response

    Symptomatic response to pantoprazole therapy does
    does not exclude the presence of malignant neoplasms of the stomach.

    Hypersensitivity and severe skin reactions

    Anaphylaxis and other serious reactions such as erythema
    multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis (TEN) have
    reported with the use of intravenous pantoprazole. It may require an emergency
    treatment .

    Injection site reactions

    Thrombophlebitis has been associated with administration
    intravenous pantoprazole.

    Potential for worsening zinc deficiency

    PROTONIX contains disodium edetate (salt form
    EDTA), a chelator of metal ions, including zinc. Therefore, zinc supplements
    should be considered in patients treated with PROTONIX I.V. for injection who
    susceptible to zinc deficiency. Caution should be exercised when using other EDTA-containing
    products are also administered intravenously.

    Clostridium Difficile associated diarrhea

    Published observational studies show that PPI therapy
    how PROTONIX may be associated with increased risk Clostridium
    associated diarrhea, especially in hospitalized patients. This
    the diagnosis should be considered in diarrhea that does not improve.

    Patients should use the lowest dose and shortest duration
    PPI therapy appropriate to the condition being treated.

    Broken bones

    Several published observational studies suggest this
    proton pump inhibitor (PPI) therapy may be associated with an increased risk
    with fractures of the hip, wrist or spine associated with osteoporosis. Risk
    the fracture was enlarged in patients treated with a high dose, defined as multiple
    daily doses and long-term PPI therapy (a year or more). Patients should use
    lowest dose and shortest duration of PPI therapy consistent with
    the condition is being treated. Patients at risk of fractures associated with osteoporosis
    should be administered in accordance with established treatment guidelines.

    Hepatic effects

    Mild, transient increases in transaminases have been
    observed in clinical studies. The clinical significance of this discovery in
    the large population of subjects receiving intravenous pantoprazole is unknown. .


    Hypomagnesemia, symptomatic and asymptomatic, was
    rarely reported in patients treated with PPIs for at least three months, and in
    most cases after a year of therapy. Serious adverse events include tetany
    arrhythmias and seizures. In most patients, treatment of hypomagnesaemia
    necessary replacement of magnesium and discontinuation of PPI

    For patients who are expected to be on long-term treatment or who
    take PPIs with drugs such as digoxin or drugs that can cause
    hypomagnesemia (eg. , diuretics), healthcare professionals may consider
    monitoring magnesium levels prior to initiating PPI treatment, and

    THC Urine Screen Interference

    Can produce THC false positive urinalysis


    Simultaneous use of protonix with methotrexate

    Literature suggests that concomitant use of PPIs with
    methotrexate (mainly at high doses;

    Preclinical toxicology
    Carcinogenesis, mutagenesis, impaired fertility

    In a 24-month Sprague-Dawley rat carcinogenicity study
    treated orally with doses of 0.5 to 200 mg/kg/day, about 0.1 to 40 times
    an effect on the body surface area of ​​a 50 kg human administered a dose of 40 mg/day.
    In the gastric fund, treatment is performed at a dose of 0.5 to 200 mg / kg / day
    enterochromaffin-like (ECL) cell hyperplasia and benign and malignant
    neuroendocrine cell tumors in a dose-dependent manner. In the forest stomach
    treatment at a dose of 50 and 200 mg / kg / day (about 10 and 40 times the recommended person
    dose based on body surface area) caused benign squamous papillomas and
    malignant squamous cell carcinomas. Rare gastrointestinal tumors are associated
    with pantoprazole treatment included duodenal adenocarcinoma at age 50
    mg / kg / day and benign polyps and adenocarcinomas of the gastric fund in 200
    mg/kg/day. The liver is treated at a dose of 0.5 to 200 mg/kg/day
    dose escalation for hepatocellular adenomas and related doses
    carcinomas. In the thyroid gland, treatment at a dose of 200 mg / kg / day increased
    frequency of follicular cell adenomas and carcinomas in both men and women

    In a 24-month Fischer rat carcinogenicity study 344
    treated orally with doses of 5 to 50 mg/kg/day, about 1 to 10
    multiply the recommended human dose based on body surface area. in the stomach
    Fundus, treated at a dose of 5 to 50 mg/kg/day, produces enterochromaffin-like (ECL)
    cell hyperplasia; and benign and malignant neuroendocrine cell tumors. Dose
    selection for this study may not have been sufficient for a comprehensive assessment
    carcinogenic potential of pantoprazole.

    In a 24-month carcinogenicity study in B6C3F1 mice,
    orally treated with doses of 5 to 150 mg/kg/day, 0. 5 to 15 times more
    recommended human dose based on body surface area. In the liver treatment at 150
    mg/kg/day caused an increase in the frequency of hepatocellular adenomas and
    carcinomas in female mice. Treatment of 5 to 150 mg/kg/day is also done
    hyperplasia of ECL cells of the stomach.

    26-week Carcinogenicity Study in Transgenic Mice
    was not positive.

    Pantoprazole was positive in in vitro people
    lymphocyte chromosomal aberration assays in one of two mouse micronuclei
    tests for clastogenic effects and in vitro Chinese hamster ovary
    direct cell mutation/HGPRT assay for mutagenic effects. Equivalent results were
    observed in an in vivo rat liver DNA covalent binding assay. Pantoprazole was
    negative in in vitro Ames mutation assay in vitro unscheduled DNA
    synthesis assay (UDS) with rat hepatocytes, in vitro AS52 / GPT mammal
    gene mutation assay in cell direction in vitro thymidine kinase mutation test
    with L5178Y mouse lymphoma cells and rat bone marrow cell in vivo
    analysis of chromosomal aberration.

    No effect on fertility or reproduction
    performance when taking pantoprazole at oral doses up to 500 mg/kg/day
    male rats (98 times the recommended human dose based on body surface area) and
    450 mg/kg/day in female rats (88 times the recommended human dose depending on the body
    surface area).

    Use in certain populations
    Teratogenic effects – Pregnancy category B

    Reproduction studies have been performed in rats in
    intravenous doses up to 20 mg/kg/day (4 times the recommended human dose
    on the body surface) and rabbits at intravenous doses up to 15 mg/kg/day (6
    times the recommended human dose depending on body surface area) and identified
    there is no evidence of impaired fertility or harm to the fetus due to pantoprazole. There
    however, there are no adequate and well-controlled studies in pregnant women.
    Because animal reproduction studies don’t always predict humans
    In response, this medication should be used during pregnancy only if clearly needed.

    Nursing mothers

    Pantoprazole and its metabolites are excreted in milk
    rats. Excretion of pantoprazole in breast milk was found in a study a
    single mother after a single dose of 40 mg. Clinical relevance
    this find is unknown. Many drugs that are excreted in breast milk have
    potential for serious adverse reactions in infants. Based
    carcinogenic potential shown for pantoprazole in rodent carcinogenicity
    research, a decision must be made whether to terminate care or
    stop taking the drug, taking into account the benefits of the drug for

    Pediatric use

    Safety and efficacy of PROTONIX I.V. in pediatric
    patients were not created.

    Geriatric use

    No age difference in safety profile
    intravenous pantoprazole has been seen in international trials involving 86 elderly people
    (≥ 65 years) and 200 young (<65 years) patients with erosive esophagitis associated with GERD. The frequency of healing of esophagitis in 107 elderly patients (≥ 65 years) treated with oral pantoprazole in the US, clinical trials were similar to those found in patients under that age out of 65.