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Risks of enemas. Enemas: Medical Uses, Risks, and Myths Debunked – A Comprehensive Guide

What are the medical uses of enemas. How do enemas work for constipation relief. Are there risks associated with enema use. Can enemas really detoxify the body. What is the history behind enema practices. How effective are coffee enemas for health benefits.

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The History and Evolution of Enema Practices

Enemas have been a part of human medical practices for millennia, with roots tracing back to ancient civilizations. The earliest documented use of enemas comes from Egypt, mentioned in the Ebers Papyrus, a medical text dating back over 3,500 years. Throughout history, enemas have served various purposes, ranging from medicinal to ritualistic.

In the 18th century, a peculiar practice emerged in Europe, particularly in London. Physicians attempted to resuscitate drowning victims by administering tobacco smoke enemas. This bizarre method, often performed along the River Thames, was based on the belief that the irritation caused by tobacco smoke would induce strong stomach contractions, forcing the lungs to expel water. However, it’s crucial to note that this is not a valid resuscitation technique and should never be attempted.

Historical Uses of Enemas

  • Providing nourishment to those unable to eat
  • Ingesting intoxicants
  • Torture methods
  • Ritualistic or religious cleansing
  • Sexual activities
  • Treating various digestive ailments

Understanding Enemas: Definition and Types

An enema is a procedure involving the injection of liquid or, occasionally, gas into the rectum via the anus. The primary purposes are to administer medication or flush out colon contents. A related procedure, colonic irrigation (often referred to as ‘a colonic’), involves a continuous flow of liquid for an extended period, aiming to clear out the colon completely.

Are there different types of enemas?

Yes, there are several types of enemas, each serving a specific purpose:

  1. Cleansing enemas: Used to relieve constipation and prepare for medical procedures
  2. Retention enemas: Designed to be held in the rectum for a period to allow absorption of medication
  3. Coffee enemas: Claimed to have detoxifying properties (though scientifically unproven)
  4. Barium enemas: Used for diagnostic imaging of the large intestine
  5. Probiotic enemas: Intended to introduce beneficial bacteria into the colon

Medical Applications of Enemas in Modern Healthcare

While the historical uses of enemas were often based on misconceptions, modern medicine has found several legitimate applications for this procedure. Physicians may recommend enemas as part of treatment plans for various gastrointestinal conditions or as preparation for certain medical procedures.

How do enemas assist in medication delivery?

Enemas can be an effective method for delivering medication directly to the source of inflammation in conditions like ulcerative colitis. The gastrointestinal tract can sometimes degrade orally consumed medications during their journey through the stomach and small intestine. By administering medications such as 5-ASAs and corticosteroids via enema, healthcare providers can ensure more targeted and effective treatment of inflammation in the rectum and large intestine.

Can enemas help with severe constipation?

In cases of severe constipation where other treatments have proven ineffective, enemas containing salt solutions can be useful in initiating a bowel movement. However, it’s important to note that this method is not recommended for frequent use due to potential health risks. Enemas for constipation should only be used under a physician’s guidance and when other options, such as dietary changes, fiber supplements, or laxatives, have failed to provide relief.

Diagnostic Uses of Enemas in Medical Procedures

Enemas play a crucial role in certain diagnostic procedures, particularly those involving the large intestine. One such application is the barium enema, which allows physicians to visualize the outline of the colon for diagnostic purposes.

What is a barium enema and how does it work?

A barium enema is a diagnostic test that involves administering a solution containing barium into the rectum. This procedure is followed by a series of X-rays. The barium coats the intestinal walls, allowing the shape and contours of the digestive tract to be clearly visible on X-ray images. This technique can help identify abnormalities such as polyps, tumors, or other structural issues in the large intestine.

While barium enemas were once a common diagnostic tool, they have largely been replaced by more advanced imaging techniques such as CT colonography and traditional colonoscopy. However, they may still be used in specific cases where these other methods are not suitable or available.

The Controversy Surrounding Detox Enemas and Colon Cleansing

In recent years, there has been a surge in popularity of so-called “detox” enemas and colon cleansing procedures, often promoted by celebrities and alternative health practitioners. These practices are based on the belief that the colon accumulates toxins over time, which can be flushed out through enemas. However, this concept is not supported by scientific evidence and has been the subject of much debate in the medical community.

Do enemas really detoxify the body?

Despite claims made by proponents of home enemas, there is no scientific evidence to support the idea that enemas can detoxify the intestinal tract, liver, or gallbladder. The human body has its own highly efficient detoxification systems, primarily the liver and kidneys, which are constantly working to remove harmful substances from our bodies.

The notion that large amounts of waste remain in the colon at any given time is also a myth. In healthy individuals, the colon is quite effective at moving waste through and out of the body. Regular bowel movements, combined with a healthy diet and lifestyle, are usually sufficient to maintain colon health without the need for invasive cleansing procedures.

Are coffee enemas beneficial for health?

Coffee enemas have gained popularity in alternative medicine circles, with proponents claiming various health benefits, including detoxification and cancer treatment. However, these claims are not supported by scientific evidence. In fact, coffee enemas can be potentially dangerous, leading to complications such as rectal burns, electrolyte imbalances, and in rare cases, septicemia.

The American Cancer Society and other reputable medical organizations do not recommend coffee enemas as a treatment for any condition. The risks associated with this practice far outweigh any potential benefits, which remain unproven.

Potential Risks and Complications of Enema Use

While enemas can be useful in certain medical situations, they are not without risks. It’s crucial to understand the potential complications associated with enema use, especially when performed without proper medical supervision.

What are the common risks associated with enema use?

Several risks can arise from improper or excessive use of enemas:

  • Electrolyte imbalances: Frequent enemas can disrupt the body’s delicate balance of electrolytes, potentially leading to serious health issues.
  • Dehydration: Excessive use of enemas can lead to fluid loss and dehydration.
  • Bowel perforation: In rare cases, the insertion of an enema tip can cause tears in the rectum or colon.
  • Infection: Improper sterilization of equipment or use of contaminated solutions can introduce harmful bacteria into the body.
  • Rectal irritation or damage: Frequent enemas can cause irritation, inflammation, or damage to the rectal tissues.
  • Dependence: Regular use of enemas for constipation relief can lead to a reliance on them for bowel movements.

It’s important to note that these risks are significantly heightened when enemas are performed at home without proper medical guidance. Always consult with a healthcare provider before considering the use of enemas for any purpose.

The Role of Enemas in Preparing for Medical Procedures

One of the most common and legitimate uses of enemas in modern medicine is in preparation for certain medical procedures, particularly those involving the lower gastrointestinal tract.

How are enemas used in colonoscopy preparation?

While oral preparations are more commonly used today, enemas can still play a role in preparing the bowel for procedures such as colonoscopies. The goal is to clear the colon of any fecal matter, allowing for clear visualization of the intestinal lining. However, it’s important to note that enemas are typically not the primary method of bowel preparation for most colonoscopies.

Most physicians now prefer oral laxative solutions for colonoscopy prep, as they are generally more effective at cleaning the entire colon. Enemas may be used as a supplementary measure or in cases where oral preparations are not suitable. Always follow your healthcare provider’s specific instructions for procedure preparation.

Debunking Myths and Misconceptions About Enemas

As with many health-related topics, there are numerous myths and misconceptions surrounding enemas. It’s crucial to separate fact from fiction to make informed decisions about health practices.

Common Myths About Enemas

  1. Myth: Enemas can cure diseases. Reality: While enemas can be useful in managing certain conditions, they are not a cure-all and should not be used as a substitute for proper medical treatment.
  2. Myth: Regular enemas are necessary for colon health. Reality: A healthy colon does not require regular cleansing beyond normal bowel movements.
  3. Myth: Enemas can help with weight loss. Reality: Any weight loss from enemas is due to temporary fluid loss and is not a healthy or sustainable method of weight management.
  4. Myth: Enemas can boost the immune system. Reality: There is no scientific evidence to support this claim. A balanced diet and healthy lifestyle are more effective ways to support immune function.
  5. Myth: Herbal enemas are always safe because they’re natural. Reality: Even natural substances can cause harm when used improperly. Herbal enemas can lead to allergic reactions or other complications.

It’s important to approach claims about enemas critically and to consult with healthcare professionals before trying any new health practice, especially one as invasive as an enema.

The Future of Enema Use in Medicine and Alternative Health Practices

As medical science continues to advance, the role of enemas in both conventional medicine and alternative health practices is likely to evolve. While some traditional uses may decline, new applications could emerge based on ongoing research and technological developments.

What does the future hold for enema use in healthcare?

In conventional medicine, the use of enemas is becoming more targeted and specialized. For instance, research is ongoing into the potential of fecal microbiota transplantation (FMT) via enema as a treatment for certain gastrointestinal conditions. This involves transferring fecal matter from a healthy donor to a recipient to restore a healthy gut microbiome.

In the realm of alternative health practices, it’s likely that enemas will continue to be promoted by some as a detoxification method, despite the lack of scientific evidence. However, as public health education improves, there may be a growing awareness of the potential risks associated with unnecessary enema use.

The future may also see the development of more advanced, safer methods for bowel cleansing and medication delivery that could reduce the need for traditional enemas. As always, it will be crucial for individuals to stay informed and consult with healthcare professionals before engaging in any health practice, including the use of enemas.

In conclusion, while enemas have a long history and some legitimate medical uses, it’s important to approach their use with caution and skepticism, especially when it comes to claims about detoxification or alternative health benefits. Always prioritize evidence-based medical advice and consult with healthcare professionals before considering any form of enema use.

Enemas – Gastrointestinal Society

Enemas have been popular for a long, long time. It makes sense that enemas were used historically; when individuals couldn’t take medicine by mouth, and before intravenous medication was common, there was only one route of administration left available! As humans paid more attention to cleaning themselves, it seemed logical to think that the place where waste left the body might require internal cleaning. However, today, there is controversy around enemas. Some celebrities, most of whom are not medical experts, claim that enemas are a cure-all with detoxifying and cleansing superpowers, but physicians are speaking out against the harms of certain popular enemas. In this article, we’ll discuss the truth about enemas, and go over some of the useful applications, as well as the more dangerous ones.

History of Enemas

An enema is a procedure that involves injecting a liquid, or occasionally a gas, into the rectum via the anus to either administer medication or flush out colon contents. Colonic irrigation (often shortened to ‘a colonic’) is a similar procedure that involves administering a continual flow of liquid for minutes to hours to clear out the colon completely rather than the single injection of enema fluid.

Humans have been using enemas for thousands of years. The oldest record of enema use comes from Egypt, mentioned in the Ebers Papyrus, a document written more than 3,500 years ago. Throughout time, people have had many reasons for using enemas, such as for providing nourishment to those unable to eat, ingesting intoxicants, torture, ritualistic or religious cleansing, sexual activity, and attempting to remedy various digestive ailments.

Medical Uses of Enemas

Sometimes an enema is the best tool in a physician’s arsenal to treat or diagnose various gastrointestinal diseases and disorders. In this section, we will outline common and effective uses of the enema.

Delivering Medication

One of the most common medical uses of the enema is to administer medication directly to the source. Individuals with ulcerative colitis experience inflammation only in the rectum and large intestine. The gastrointestinal tract can digest or degrade medications orally consumed during its journey through the stomach and small intestine. For this reason, some medications for ulcerative colitis, such as 5-ASAs and corticosteroids, are available in enema form to deliver the medication directly to the inflamed area for more effective treatment.

Constipation Relief

Enemas can be useful for those with severe constipation. When other treatments, such as dietary intervention, fibre supplements, or laxatives are ineffective, enemas containing salt solutions can help initiate a bowel movement. However, this method isn’t recommended for frequent use, and should only be done in cases where nothing else works, and when your physician gives you the okay, as there are more health risks with enemas than there are with standard constipation treatments.

Bowel Emptying

Your physician might recommend using an enema before a procedure or surgery that requires an empty intestine, such as colonoscopy. However, it is more likely that they will give you an oral preparation that clears out the colon than recommend an enema.

Diagnostic Tests

If your physician wants to see the outline of your large intestine for diagnostic purposes, they might use a barium enema. This involves administration of a solution containing barium, followed by a series of X-rays. The barium coats the intestinal walls and allows the shape of your digestive tract to show up in X-rays.

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A strange type of enema found throughout Europe, especially London, in the 18th century involved blowing tobacco smoke into the anus of individuals who had drowned. Physicians at the time believed that this procedure would help resuscitate these individuals, and it was a regular occurrence along the River Thames. The theory behind this procedure was that the tobacco smoke would irritate the bowels, which would cause the stomach to contract so strongly that it would force the lungs to cough. As explained by one physician from the time, “for the heat and sharpness of the tobacco smoke irritate so much the bowels, as to cause a violent contraction of the belly, which forces out of the breast the air contained in it.”3

Note: this is not a valid resuscitation method!

Myths about Enemas

Enemas Detoxify

Many proponents of home enemas claim that the main reason to perform enemas is to detoxify the intestinal tract, liver, and/or gallbladder. You might also hear claims that at any given time, a large amount of waste stays in your colon. However, this isn’t true, unless you are very constipated. Even then, whenever you have a bowel movement, it pushes things out roughly in the order it went in. Any waste that you eliminate during an enema is from recent meals and would have been eliminated during normal bowel movements in due time.

Enemas Are Safe

While enemas can be a useful tool in medicine, giving yourself enemas at home can have many complications. An incorrectly administered enema can damage tissue in your rectum/colon, cause bowel perforation and, if the device is not sterile, infections.1 Long-term, regular use of enemas can cause electrolyte imbalances. Temporary side effects of enemas can include bloating and cramping.

Enemas can also affect the balance of microbiota in your gut. Many proponents of using home enemas to ‘detoxify’ often cite this as a good effect, saying it helps flush out harmful bacteria. However, enemas also negatively affect the good bacteria in the gut (probiotics), which can damage the microbiota balance and cause digestive symptoms.

Coffee Enemas Are Beneficial

Coffee enemas first became popular in the 1920s, when a German scientist, Max Gerson, claimed that coffee enemas were more effective than standard saline enemas, because the coffee would be absorbed rectally, and could help stimulate the liver. Supposedly, this would detoxify the body and could even help cure cancer. However, it is important to note that in the past century, no researchers have published any quality studies showing that coffee enemas can improve health, and the scientific community continues to discredit Gerson’s unfounded ideas.2

Coffee can offer health benefits – such as antioxidants – when you drink it, but there is no advantage to taking coffee rectally. In fact, it comes with the risk of normal enema complications, and the potential for rectal burns if the coffee is too warm. It is also possible to take in too much caffeine, if you are using larger amounts of coffee than you would normally drink. If you want to enjoy coffee, it is best to enjoy drinking it in moderation.

Conclusion

While enemas definitely have their uses, there aren’t many situations where they are necessary. We have safer methods of medication administration, and we know that using enemas regularly doesn’t help detoxify or cleanse your colon. If your physician does recommend you use an enema for any reason, make sure to follow their instructions carefully to avoid unpleasant side effects and injuries.

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Shepherd of the Royal Anus

In Ancient Egypt, a wide range of physicians would attend to their Pharaoh, with each one attending to a different body part. One such position, the Shepherd of the Royal Anus (neru pehut), had the primary duty of providing the Pharaoh with regular enemas, either to administer medicines or to clean out the colon.4


First published in the

Inside Tract® newsletter issue 206 – 2018

1. Niv G

et al. Perforation and mortality after cleansing enema for acute constipation are not rare but are preventable. International Journal of General Medicine. 2013:6;323–328.
2. Cassileth B. Gerson regimen. Oncology (Williston Park). 2010;24(2):201.
3. Bruhier, Jacques-Jean, -1756. To the publick. A new method of relieving such persons as are thought to be suffocated, or drowned. [n.p., 1748].
4. Barr J. Vascular medicine and surgery in ancient Egypt. Journal of Vascular Surgery. 2014;60(1):260-3.

Images: © Wayhome Studio | Bigstockphoto.com, Photo: © toxitz | Bigstockphoto.com

Colonic Uses, History, and Complications

A colonic is the infusion of water or other liquids into the rectum by a colon therapist to cleanse and flush out the colon. It is also called colonic hydrotherapy or colon irrigation. Colonics and enemas are similar, but there are some key differences between a colonic and an enema. Learn about who needs one, what to expect, and how to manage potential complications.

Verywell / Brianna Gilmartin

What Is a Typical Colonic Like?

After completing a health history form and consulting with the colon hydrotherapist, the client is asked to change into a gown and lie face up on a treatment table.

The colon therapist inserts a disposable speculum into the anus. The speculum is connected to a long disposable plastic hose connected to the colon hydrotherapy unit.

The client and the colon therapist do not smell the feces as it is filtered through the tube. The therapist usually looks at the feces through the clear hose and may comment on the color.

The client typically feels some discomfort in the abdomen during the therapy. The colon therapist may apply light massage to the client’s abdominal area to facilitate the process.

After the session, the therapist leaves the room, and the client may sit on a toilet to pass any residual water and stool. A typical session lasts 45 minutes to one hour.

Why Do People Get Colonics?

People who get colonics typically say they do it for the following reasons:

  • To remove accumulated waste from the colon
  • To help prevent constipation
  • To improve the overall health

Colonics are always considered a form of alternative medicine. Due to lack of evidence, colonics are not known to improve health and wellness by most conventional medical professionals.

Thus far, scientific support for the potential health benefits of colonics is lacking because there is no hard evidence to back up these claims. However, proponents of colon hydrotherapy claim that accumulated fecal matter in the colon may negatively affect health in some of the following ways:

  • Preventing water and nutrient absorption
  • Lead to constipation
  • Allow harmful colon bacteria and yeast to grow
  • Cause stagnant toxins to be absorbed into the bloodstream through the colon wall (called autointoxication)

Lack of fiber, excess sugar, and a diet high in red meat are believed to contribute to the problem.

History of Colonics

One of the earliest proponents of colonics and the autointoxication theory was John Harvey Kellogg, MD, founder of the Kellogg cereal company. Many credit Kellogg for the popularity of colonics among conventional physicians from the early 1900s to the 1940s.

Kellogg frequently lectured on colon therapy and recommended colonics for many conditions, such as depression and arthritis. As laxatives grew in popularity, colonics became less popular.

Also, the lack of published evidence on the benefits of colonics contributed to its decline. Today, some alternative practitioners continue to recommend colonics.

Complications

People with certain conditions, such as diverticular disease, ulcerative colitis, Crohn’s disease, severe hemorrhoids, blood vessel disease, congestive heart failure, heart disease, severe anemia, abdominal hernia, gastrointestinal cancer, recent colon surgery, and intestinal tumors are among those who should not have a colonic.

People who are pregnant should not have a colonic as it may stimulate uterine contractions.

Side effects of colonics may include nausea and fatigue after the session, which can last for several hours. Complications may include bowel perforation, excessive fluid absorption, electrolyte imbalance, heart failure, and serious infection. 

To Enema or Not to Enema – Digestive Center – EverdayHealth.com

Coffee enemas have been making headlines recently after a Florida couple caught national attention by allegedly using coffee enemas up to four times a day to cleanse their colons. But the debate about whether enemas are helpful has been ongoing since the early 1900s. The concept of colon cleansing for better digestive health or reduction of body toxins might sound appealing, but there’s little medical evidence to suggest that enemas actually help your digestive tract or relieve constipation.

Enemas for Digestive Health?

“Your body is designed to process your waste effectively,” says gastroenterologist David Greenwald, MD, a professor of clinical medicine at the Albert Einstein College of Medicine in the Bronx, N.Y. That doesn’t mean it’s a perfect system or that you’ll always enjoy the results. Everyone has occasional bouts of constipation and diarrhea. But according to Dr. Greenwald, you don’t need to invest in enemas. Treatments such as enemas could be an easy sell because society tends to view defecation as “dirty,” so giving the body a helping hand in the process of cleansing might seem like a good thing. Not so, he says.

Those who promote the use of enemas might be capitalizing on these thoughts by emphasizing that enemas are cleansing or, in some cases, contain natural or herbal ingredients such as chamomile or caffeine, Greenwald says, but he stresses that there’s no medical support for the use of herbs or other materials in an enema.

Enemas are also touted for weight-loss purposes, but Greenwald disputes their usefulness for this purpose as well. “We are not carrying around pounds of unprocessed waste,” he says. There are also some practical reasons to forego an enema:

  • Cost. “They’re expensive,” Greenwald points out, adding that people can expect to pay $100 or more for a boutique enema. If you’re going to fork out that much, pay for something you’ll be sure to find relaxing, like a massage.
  • Side effects. Nausea, vomiting, and diarrhea are all possible side effects of an enema, warn the researchers who covered the risks of colon cleansing in a clinical article for The Journal of Family Practice.
  • Risks. Enema risks include perforation of the rectum, which requires surgery to repair and possible damage to internal organs. Furthermore, the “washing” out of the rectum and intestine can interfere with your body’s normal absorption of nutrients and fluids, leading to chemical imbalances.
  • Dependency. People can develop a habit of using enemas to create bowel movements, but you can (and should) break this habit. Talk to your doctor about how to do so and what should be a realistic expectation for your bowel movements.

Take a Pass on the Enema Fad

If you’re wondering whether you’ve somehow missed out on the digestive benefits by choosing to drink your morning coffee in a mug instead of inserting it in an enema, fret not. Thai researchers tested the effects of hot coffee drinks and hot coffee enemas with 11 men and found that there was no difference in the measures of antioxidant benefit between the two groups. So if you want the health benefits of coffee, stick with drinking your morning cup of Joe.

Additionally, there’s no reason to think you’ll get a caffeine high from an enema, at least not a greater high than you’d get from drinking it, says Greenwald.

Enema Alternatives

The medical use of enemas to treat constipation is recommended for severe cases only and ideally with the consultation of your doctor. Alternatives to enemas abound. If you’re troubled by constipation or other digestive problems, you should consider changing your diet to include more fiber, drinking more water to move things along, and being physically active.

If bowel movements become painful or are interfering with your quality of life — either because they’re too frequent or not frequent enough — talk to your doctor.

Perforation and mortality after cleansing enema for acute constipation are not rare but are preventable

Int J Gen Med. 2013; 6: 323–328.

Galia Niv

1Risk Management and Quality Assurance, Beilinson Hospital and Tel Aviv University, Tel Aviv, Israel

Tamar Grinberg

2Emergency Department, Beilinson Hospital and Tel Aviv University, Tel Aviv, Israel

Ram Dickman

3Department of Gastroenterology, Beilinson Hospital and Tel Aviv University, Tel Aviv, Israel

Nir Wasserberg

4Department of Surgery B, Rabin Medical Center, Beilinson Hospital and Tel Aviv University, Tel Aviv, Israel

Yaron Niv

1Risk Management and Quality Assurance, Beilinson Hospital and Tel Aviv University, Tel Aviv, Israel

3Department of Gastroenterology, Beilinson Hospital and Tel Aviv University, Tel Aviv, Israel

1Risk Management and Quality Assurance, Beilinson Hospital and Tel Aviv University, Tel Aviv, Israel

2Emergency Department, Beilinson Hospital and Tel Aviv University, Tel Aviv, Israel

3Department of Gastroenterology, Beilinson Hospital and Tel Aviv University, Tel Aviv, Israel

4Department of Surgery B, Rabin Medical Center, Beilinson Hospital and Tel Aviv University, Tel Aviv, Israel

Correspondence to: Yaron Niv, Rabin Medical Center, 39 Jabotinski Street, Petach Tikva, Israel Tel +972 3 937 7328 Fax +972 3 921 0313 Email li. gro.tilalc@vinyCopyright © 2013 Niv et al, publisher and licensee Dove Medical Press Ltd

This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.

This article has been cited by other articles in PMC.

Abstract

Objectives

Constipation is a common complaint, frequently treated with cleansing enema. Enemas can be very effective but may cause serious adverse events, such as perforation or metabolic derangement. Our aim was to evaluate the outcome of the use of cleansing enema for acute constipation and to assess adverse events within 30 days of therapy.

Methods

We performed a two-phase study: an initial retrospective and descriptive study in 2010, followed by a prospective study after intervention, in 2011. According to the results of the first phase we established guidelines for the treatment of constipation in the Emergency Department and then used these in the second phase.

Results

There were 269 and 286 cases of severe constipation in the first and second periods of the study, respectively. In the first study period, only Fleet® Enema was used, and in the second, this was changed to Easy Go enema (free of sodium phosphate). There was a 19.2% decrease in the total use of enema, in the second period of the study (P < 0.0001). Adverse events and especially, the perforation rate and the 30-day mortality in patients with constipation decreased significantly in the second phase: 3 (1.4%) versus 0 (P = 0.0001) and 8 (3.9%) versus 2 (0.7%) (P = 0.0001), for perforation and death in the first and second period of the study, respectively.

Conclusion

Enema for the treatment of acute constipation is not without adverse events, especially in the elderly, and should be applied carefully. Perforation, hyperphosphatemia (after Fleet Enema), and sepsis may cause death in up to 4% of cases. Guidelines for the treatment of acute constipation and for enema administration are urgently needed.

Keywords: phospho-soda, elderly, dementia, obstipation

Introduction

Constipation is a common complaint and is associated with significant health care costs. 1 The elderly are five times more prone to constipation than young people, due to the effect of medication, immobility, and blunted urge to defecate.2 Polypharmacy is very frequent among the elderly, and drugs such as pain killers (opiates), antipsychotic, antiparkinson agent, anticholinergic, anxiolytics, calcium, and iron supplements, which are popularly prescribed in the advanced age group, are known to have constipation as a side effect.

Most patients self-medicate to treat constipation, usually with over-the-counter (OTC) drugs, but some need urgent intervention and are referred to the Emergency Department (ED). Many of these patients are demented, have cognitive deficits, or suffer from a psychiatric disorder. The communication between the treating team and these patients may be impaired, and the proper feedback about pain or the side effect of treatments is not optimal.

Acute constipation requires urgent and comprehensive assessment because a serious medical condition may be the underlying cause. A careful medical history, investigation of medications that can cause constipation, and physical examination including rectal examination are important in all patients with severe constipation, in order to define the type of constipation and direct the physician to the correct diagnosis, treatment, and intervention. Rectal examination can assess sphincter tone and tenderness, and may uncover a palpable mass, fissure, or mucosal prolapse.2,3 Even though constipation is a common condition seen in the ED, there has been unequal distribution of knowledge among physicians and nurses regarding this issue, which may explain the wide variance of management and treatment methods for this problem.

Cleansing enema is a popular method for treatment of constipation. The function of enema is dependent on several different mechanisms. By distending the rectum, all enemas stimulate the colon to contract and eliminate stool. Other mechanisms, such as that employing phosphate enemas, directly stimulate the muscles of the colon. Enemas can be very effective but may cause serious adverse events, such as perforation or metabolic derangement.4 Hypertonic sodium phosphate enemas may cause severe phosphate nephropathy, especially in the elderly with chronic renal failure or in patients treated with angiotensin-converting enzyme (ACE) inhibitors.59 Cleansing enema adverse events are rarely reported in the literature but may be life threatening. The most frequent cause of perforation in patients who underwent enema has been reported to be the device tip; other causes are related to localized weakness of the rectal wall, obstruction, or the position of the patient when the enema was performed.1017 We are not aware of any previous study that has looked at the incidence of perforation after enema treatment for acute constipation.

Our aim was to evaluate the outcome of using cleansing enema for severe, acute constipation, in patients referred to the ED of Rabin Medical Center, Beilinson Hospital and to assess the adverse events within 30 days of therapy.

Patients and methods

A retrospective (first phase) study was conducted between January 1, 2010 and December 31, 2010. We studied all the patients that were referred to the ED on an emergency basis because of severe constipation. We included all patients referred, without exclusion.

Patients’ records were reviewed. The data collection included: gender, age, medical history, the results of physical examination, the results of imaging procedures, the type of treatment for constipation, and the outcome assessment, including treatment effectiveness and discharge or hospitalization. We also looked at return visits to the ED within 1 week and 30-day mortality.

A prospective, interventional (second phase) study followed between March 1, 2011 and Feb 29, 2012, using the same methods, after having developed, distributed, and implemented the use of clinical guidelines for the treatment of constipation.

The process of guidelines formation

An expert committee was convened that included experienced physicians from the departments of Surgery, Gastroenterology, Geriatrics, Nephrology, and Emergency Medicine, and experts from the Risk-Management Unit and Pharmacy. The literature was reviewed, and the results of the retrospective study were discussed. Clinical guidelines for the diagnosis and treatment of acute constipation were written and distributed in the medical center. An implementation program was carried out in the ED, over a period of 2 months.

Statistical evaluation

The statistical analysis was performed using SPSS for Windows (version 16.0; IBM, Armonk, NY, USA). Categorical data were described proportionally using descriptive statistics. A difference in proportions was tested by Chi-square statistics, with continuity adjustment or Fisher’s exact test applied where appropriate. The level of significance adopted was 0.05.

Results

Demographic and clinical data

There were 97,500 and 99,000 visits to the ED at Beilinson Hospital, Rabin Medical Center, in the first and second phases of the study, respectively. The number of patients with constipation was similar, 269 (0.27%) and 286 (0.29%), respectively (). Most of the patients were older than 65 years. There was no statistically significant difference in age and gender between the groups. The length of stay in the ED was significantly shorter in the second period of the study.

Table 1

Period 1Period 2P
Number of total ED visits per year97,50099,000
Number of patients with constipation referred to ED269 (0. 27%)286 (0.29%)NS
Average age ± SD (years)64.5 ± 21.862.8 ± 22.7NS
Age
 20–49 years62 (23.0%)78 (27.2%)NS
 50–64 years42 (15.6%)51 (17.8%)NS
 65–93 years165 (61. 3%)157 (54.9%)NS
Sex
 Female142 (52.8%)142 (49.6%)NS
 Male127 (47.2%)144 (50.4%)NS
Shifts
 Morning (07:00–14:59)118 (43.8%)127 (44. 4%)NS
 Evening (15:00–22:59)118 (43.9%)133 (46.5%)NS
 Night (23:00–06:59)33 (12.3%)26 (9.1% )NS
Length of stay at ED: average ± SD (hours)9.1 ± 5.75.5 ± 4.2<0.0001

Diagnosis and treatment

The abdominal examination was normal in most of the patients in both study periods, and the physical signs were also similar between the groups. A rectal digital examination was performed in 89.6% and 99.3% of the patients in the first and second periods, respectively (P < 0.0001) (). Fecal stones were found in 37 patients and a rectal tumor in five. Hemoglobin, white blood cell count, and creatinine levels were similar in both periods. More X-ray studies were performed in the second period. Paralytic ileus was demonstrated in four patients and was suspected in 12 patients.

Table 2

Signs, symptoms, and laboratory test results

Period 1Period 2P
N269286
Vital signs (mean ± SD)
 Pulse81 ± 1582 ± 16NS
 Fever36. 7 ± 0.336.7 ± 0.4NS
 VAS pain score4.2 ± 3.23.7 ± 3.10.062
Blood pressure
 Systole, mean ± SD138 ± 26138 ± 24NS
 Diastole, mean ± SD72 ± 1573 ± 12NS
Abdominal examination performed in ED265 (98. 5%)286 (100.0%)NS
 Abdominal tenderness17 (6.4%)19 (6.6%)NS
 Abdominal distention16 (6.0%)13 (4.5%)NS
 Suspected incarcerated hernia1 (0.4%)0NS
 Abdominal fullness12 (4. 5%)5 (1.7%)0.095
 Normal abdominal examination223 (84.1%)249 (87.1%)NS
Digital rectal examination performed in ED241 (89.6%)284 (99.3%)<0.0001
 Refused rectal examination6 (2.2%)4 (1.4%)NS
 Fecal stone22 (9. 1%)15 (5.3%)NS
 External hemorrhoids3 (1.2%)5 (1.8%)NS
 Rectal SOL4 (1.6%)1 (0.3%)NS
 Benign prostate hypertrophy2 (0.8%)3 (1.0%)NS
 Normal PR examination232 (96. 3%)258 (90.8%)NS
Blood tests (mean ± SD)
 Hemoglobin12.1 ± 1.412.2 ± 1.6NS
 WBC8596 ± 35438064 ± 2535
 Creatinine0.9 ± 0.50.9 ± 0.3
Abdominal X-ray performed in ED260 (96. 6%)285 (99.56%)0.045
 Paralytic ileus3 (1.1%)1 (0.3%)NS
 Expansion of bowel loops7 (2.7%)5 (1.7%)NS

Cleansing enema was performed in 76.9% and 57.7% of the patients in the first and second period of the study, respectively (P < 0.0001) (). In the first period, only Fleet® Enema (phospho-soda) (Fleet Co, Inc, Lynchburg, VA , USA) was used, and in the second period, this was changed to Easy Go enema (Gilco Pharm Ltd, Rishon Le-Zion, Israel) that is free of sodium and phosphate. Age, renal function, blood pressure, or drugs (including ACE inhibitors and ACE antagonists) were not taken into consideration before treatment with Fleet Enema. A combination therapy of cleansing enema and oral laxative was used in more patients during the first period of study; laxative with no additional enema was used in more patients during the second period.

Table 3

Treatments for constipation in the ED

Period 1Period 2P
N269286
Enema administration in ED207 (76. 9%)165 (57.7%)<0.0001
Enema + PO133 (49.4%)58 (20.2%)<0.0001
Only PO46 (17.1%)85 (29.7%)0.001
Telebrix® (Guerbet, Villepinte, France)39 (14.4%)25 (8.7%)0. 033
Paraffin oil104 (38.7%)89 (31.1%)NS
Avilac (Amvilabs Inc, Atlanta GA, USA)111 (41.2%)92 (32.1%)0.034
Pain killer17 (6.3%)16 (5.6%)NS
No treatment13 (4. 8%)34 (11.9%)0.011

Follow up and outcome

Reassessment before discharge from ED was performed in 79.8% and 99.6% in the first and second period, respectively (P < 0.0001) (). The perforation rate and the 30-day mortality were significantly higher in the first than in the second period studied. The causes of death are given in . One patient in the first period of the study died after Fleet Enema because of hyperphosphatemia and phosphate nephropathy. The rate of return visits was also higher in the first period.

Table 4

Period 1Period 2P
N269286
Reassessment before discharge from ED (out of discharged patients)201 (79. 8%)263 (99.6%)<0.0001
Revisit ED within 1 week for the same reason37 (13.7%)24 (8.4%)<0.0001
Hospitalization15 (5.6%)22 (7.7%)NS
Rectal perforation3 (1.4%)0<0. 0001
30-day mortality8 (3.9%)2 (0.7%)<0.0001

Table 5

Characteristics of patients who died

SexAgePR findingsAbdominal examination findingsX-ray findingsTreatmentReassessment after treatmentDeathComments
Period 1
Female86NormalNormalNot doneFleet® enema (Fleet Co, Inc, Lynchburg, VA, USA)NoWithin 1 dayHyperphosphatemia
Female52Fecal stonesNormalNot doneFleet enema, Avilac (Amvilabs Inc, Atlanta, GA, USA), paraffinYesWithin 1 dayImpaired patient, lost for follow-up
Female76Fecal stonesNormalNot doneFleet enema, Telebrix® (Guerbet, Villepinte, France)YesWithin 5 daysLost for follow-up
Female86NormalInguinal herniaNormalFleet enema, AvilacYesWithin 6 daysLost for follow-up
Female93NormalNormalNormalFleet enema, AvilacPerforationWithin 11 daysImmediate operation
Male86Not doneNormalNormalFleet enemaNoWithin 21 daysPerforation was found at the return visit 3 days after enema administration
Male55NormalInflationNormalFleet enemaNoWithin 3 weeksEnema performed under severe neutropenia. Hospitalization for sepsis 4 days later
Male81NormalNormalNormalFleet enemaYesWithin 1 monthPneumonia
Male72NormalTendernessNot doneFleet enemaNoWithin 3 daysPerforation 9 hours after enema that was performed in another hospital
Period 2
Male64NormalTendernessNormalNo enemaYesWithin 3 weeksEnd-stage cancer
Female89NormalNormalNormalNo enemaYesWithin 1 monthEnd-stage cancer

Clinical guidelines

The guidelines included instructions for diagnosis and the treatment of acute constipation in the ED, the identification of enema risk factors, description of the method of enema administration and follow-up, and recommendation for the specific enema type.

Diagnosis

When acute constipation is suspected, fecal impaction, rectal tumor, and colonic obstruction should be excluded by a compre­hensive abdominal and rectal examination. Drugs and underly­ing diseases that may cause constipation should be excluded. X-ray study is indicated according to the clinical picture.

Treatment

The use of Fleet Enema (phospho-soda) is forbidden due to the danger of hyperphosphatemia and phosphate nephropathy. Cleansing enema should be performed carefully with another product, and the volume should not exceed 250 mL. Administration of the enema is done with a rectal tube, by experienced personnel. Perforation should always be anticipated and suspected if abdominal pain appears. Cleansing enema is contraindicated in patients with fecal stones, rectal obstruction by tumor or rectal prolapse, active coronary heart disease, and in comatose or noncompliant patients. In addition, enema should be avoided in cancer patients under chemotherapy and in other immunocompromised patients, especially those with severe neutropenia.

Follow up and outcome

Before patient discharge from the ED, reassessment of the clinical status should be performed and includes physical abdominal examination and measurement of vital signs. Instructions about adverse events or complications that could occur should be discussed. The patient is instructed to return immediately to the ED if rectal bleeding occurs or if abdominal pains appear.

Discussion

Quality and risk management processes are an essential part of our daily work, in order to improve patient management and safety. We believe that these processes should be based on evidence and good clinical research. In this study, we looked at a very common complaint of constipation, after an anecdotal impression of a high incidence of perforation and mortality.

Constipation is increasingly found in the elderly population and is becoming an important cause of morbidity.13 The constipation rate in the Western world is 2%–28%. 3 Emergency room visits due to acute constipation in the United States are estimated to be 0.22% to 0.36%, very similar to our results.18 Cleansing enema is a popular practice for the treatment of constipation and is used in many patients referred for this reason to the ED.19 Since enema is dispensed as an OTC medication in many countries, many patients arrive at the ED after enema treatment that is not always reported.

In our daily practice we encountered cases of perforation and mortality after cleansing enema but could trace only case reports or small cohort studies in the literature; we could not find any study looking at the incidence of enema complications or adverse events.1017

Two case series from Israel described elderly patients that had perforation after cleansing enema.10,11 Paran et al10 described 13 cases of colon perforation occurring after a cleansing enema performed at home or a nursing home, over a 3-year period, in patients with a mean age of 64. 3 years, similar to our group. Gayer et al11 described 14 cases of rectosigmoid perforations that were picked up from the CT scan database in a period of 6 years. These patients were older, with an average age of 80 years. Since these articles did not mention the total number of patients that were hospitalized during the studies, the incidence could not be calculated.

Because enema is freely available and largely self-administered, with no or little inspection, we could not estimate the true rate of adverse events related to its use. Our study is the first to demonstrate the incidence of adverse events and the 30-day mortality rate after cleansing enema performed by a nurse, in acutely constipated patients treated at an ED. We found three cases of rectal perforation and one case of hyperphosphatemia in the first period of the study compared with no cases in the second period, and this may be due to the new comprehensive guidelines that were established and implemented by the physicians and nurses. The main difference in clinical behavior between the periods of the study was the preference for oral laxatives over enemas and the careful reassessment of the patient prior to discharge, shown in the second period. Of course, we could not separate the role of the enema in causing perforation and mortality from the other potential factors. In addition, we recommended using a flexible rectal tube to overcome the danger of perforation due to the rigid tip of the enema.

Patients presenting to the ED can be demented, have cognitive deficits, or have psychiatric disorder, and in these situations, communication is not optimal and sometimes lacking. Thus, invasive procedures requiring understanding and consent should be avoided as much as possible. Moreover these patients can have a high incidence of fecal impaction and fecal stones, which may cause stercoral ulcers and perforation.16 Perforation, if this occurs, is on a background of a colon full of fecal material and carries a very high risk of peritoneal spilling and peritonitis. The issue of phosphate enema is also important, and we believe this medication should not be used. There are many descriptions of phosphate nephropathy, in addition to the case that occurred in our study.

The limitations of our study arise from being a single center experience and from the lack of clinical information (medical history and medications) about the patients studied. In the ED, the medical history taken is not as comprehensive as for hospitalized patients.

In conclusion, enema for the treatment of acute constipation is not without adverse events, especially in the elderly, and should be applied carefully. Perforation, hyperphosphatemia (after Fleet Enema), and sepsis may occur, causing death in up to 4% of cases. National guidelines for the treatment of acute constipation and for enema administration are urgently needed.

Author contributions

Galia Niv contributed to the study conceptualization, data collection, data analysis, preparation of the manuscript, and was responsible for study supervision; Tamar Grinberg participated in data collection; Nir Waserberg and Ram Dickman participated in study conceptualization, patient management; Yaron Niv contributed to the study conceptualization, data collection, data analysis, preparation of the manuscript, and was responsible for study supervision.

Footnotes

Disclosure

The authors report no conflicts of interest in this work.

References

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Perforation and mortality after cleansing enema for acute constipation are not rare but are preventable

Int J Gen Med. 2013; 6: 323–328.

Galia Niv

1Risk Management and Quality Assurance, Beilinson Hospital and Tel Aviv University, Tel Aviv, Israel

Tamar Grinberg

2Emergency Department, Beilinson Hospital and Tel Aviv University, Tel Aviv, Israel

Ram Dickman

3Department of Gastroenterology, Beilinson Hospital and Tel Aviv University, Tel Aviv, Israel

Nir Wasserberg

4Department of Surgery B, Rabin Medical Center, Beilinson Hospital and Tel Aviv University, Tel Aviv, Israel

Yaron Niv

1Risk Management and Quality Assurance, Beilinson Hospital and Tel Aviv University, Tel Aviv, Israel

3Department of Gastroenterology, Beilinson Hospital and Tel Aviv University, Tel Aviv, Israel

1Risk Management and Quality Assurance, Beilinson Hospital and Tel Aviv University, Tel Aviv, Israel

2Emergency Department, Beilinson Hospital and Tel Aviv University, Tel Aviv, Israel

3Department of Gastroenterology, Beilinson Hospital and Tel Aviv University, Tel Aviv, Israel

4Department of Surgery B, Rabin Medical Center, Beilinson Hospital and Tel Aviv University, Tel Aviv, Israel

Correspondence to: Yaron Niv, Rabin Medical Center, 39 Jabotinski Street, Petach Tikva, Israel Tel +972 3 937 7328 Fax +972 3 921 0313 Email li. gro.tilalc@vinyCopyright © 2013 Niv et al, publisher and licensee Dove Medical Press Ltd

This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.

This article has been cited by other articles in PMC.

Abstract

Objectives

Constipation is a common complaint, frequently treated with cleansing enema. Enemas can be very effective but may cause serious adverse events, such as perforation or metabolic derangement. Our aim was to evaluate the outcome of the use of cleansing enema for acute constipation and to assess adverse events within 30 days of therapy.

Methods

We performed a two-phase study: an initial retrospective and descriptive study in 2010, followed by a prospective study after intervention, in 2011. According to the results of the first phase we established guidelines for the treatment of constipation in the Emergency Department and then used these in the second phase.

Results

There were 269 and 286 cases of severe constipation in the first and second periods of the study, respectively. In the first study period, only Fleet® Enema was used, and in the second, this was changed to Easy Go enema (free of sodium phosphate). There was a 19.2% decrease in the total use of enema, in the second period of the study (P < 0.0001). Adverse events and especially, the perforation rate and the 30-day mortality in patients with constipation decreased significantly in the second phase: 3 (1.4%) versus 0 (P = 0.0001) and 8 (3.9%) versus 2 (0.7%) (P = 0.0001), for perforation and death in the first and second period of the study, respectively.

Conclusion

Enema for the treatment of acute constipation is not without adverse events, especially in the elderly, and should be applied carefully. Perforation, hyperphosphatemia (after Fleet Enema), and sepsis may cause death in up to 4% of cases. Guidelines for the treatment of acute constipation and for enema administration are urgently needed.

Keywords: phospho-soda, elderly, dementia, obstipation

Introduction

Constipation is a common complaint and is associated with significant health care costs. 1 The elderly are five times more prone to constipation than young people, due to the effect of medication, immobility, and blunted urge to defecate.2 Polypharmacy is very frequent among the elderly, and drugs such as pain killers (opiates), antipsychotic, antiparkinson agent, anticholinergic, anxiolytics, calcium, and iron supplements, which are popularly prescribed in the advanced age group, are known to have constipation as a side effect.

Most patients self-medicate to treat constipation, usually with over-the-counter (OTC) drugs, but some need urgent intervention and are referred to the Emergency Department (ED). Many of these patients are demented, have cognitive deficits, or suffer from a psychiatric disorder. The communication between the treating team and these patients may be impaired, and the proper feedback about pain or the side effect of treatments is not optimal.

Acute constipation requires urgent and comprehensive assessment because a serious medical condition may be the underlying cause. A careful medical history, investigation of medications that can cause constipation, and physical examination including rectal examination are important in all patients with severe constipation, in order to define the type of constipation and direct the physician to the correct diagnosis, treatment, and intervention. Rectal examination can assess sphincter tone and tenderness, and may uncover a palpable mass, fissure, or mucosal prolapse.2,3 Even though constipation is a common condition seen in the ED, there has been unequal distribution of knowledge among physicians and nurses regarding this issue, which may explain the wide variance of management and treatment methods for this problem.

Cleansing enema is a popular method for treatment of constipation. The function of enema is dependent on several different mechanisms. By distending the rectum, all enemas stimulate the colon to contract and eliminate stool. Other mechanisms, such as that employing phosphate enemas, directly stimulate the muscles of the colon. Enemas can be very effective but may cause serious adverse events, such as perforation or metabolic derangement.4 Hypertonic sodium phosphate enemas may cause severe phosphate nephropathy, especially in the elderly with chronic renal failure or in patients treated with angiotensin-converting enzyme (ACE) inhibitors.59 Cleansing enema adverse events are rarely reported in the literature but may be life threatening. The most frequent cause of perforation in patients who underwent enema has been reported to be the device tip; other causes are related to localized weakness of the rectal wall, obstruction, or the position of the patient when the enema was performed.1017 We are not aware of any previous study that has looked at the incidence of perforation after enema treatment for acute constipation.

Our aim was to evaluate the outcome of using cleansing enema for severe, acute constipation, in patients referred to the ED of Rabin Medical Center, Beilinson Hospital and to assess the adverse events within 30 days of therapy.

Patients and methods

A retrospective (first phase) study was conducted between January 1, 2010 and December 31, 2010. We studied all the patients that were referred to the ED on an emergency basis because of severe constipation. We included all patients referred, without exclusion.

Patients’ records were reviewed. The data collection included: gender, age, medical history, the results of physical examination, the results of imaging procedures, the type of treatment for constipation, and the outcome assessment, including treatment effectiveness and discharge or hospitalization. We also looked at return visits to the ED within 1 week and 30-day mortality.

A prospective, interventional (second phase) study followed between March 1, 2011 and Feb 29, 2012, using the same methods, after having developed, distributed, and implemented the use of clinical guidelines for the treatment of constipation.

The process of guidelines formation

An expert committee was convened that included experienced physicians from the departments of Surgery, Gastroenterology, Geriatrics, Nephrology, and Emergency Medicine, and experts from the Risk-Management Unit and Pharmacy. The literature was reviewed, and the results of the retrospective study were discussed. Clinical guidelines for the diagnosis and treatment of acute constipation were written and distributed in the medical center. An implementation program was carried out in the ED, over a period of 2 months.

Statistical evaluation

The statistical analysis was performed using SPSS for Windows (version 16.0; IBM, Armonk, NY, USA). Categorical data were described proportionally using descriptive statistics. A difference in proportions was tested by Chi-square statistics, with continuity adjustment or Fisher’s exact test applied where appropriate. The level of significance adopted was 0.05.

Results

Demographic and clinical data

There were 97,500 and 99,000 visits to the ED at Beilinson Hospital, Rabin Medical Center, in the first and second phases of the study, respectively. The number of patients with constipation was similar, 269 (0.27%) and 286 (0.29%), respectively (). Most of the patients were older than 65 years. There was no statistically significant difference in age and gender between the groups. The length of stay in the ED was significantly shorter in the second period of the study.

Table 1

Period 1Period 2P
Number of total ED visits per year97,50099,000
Number of patients with constipation referred to ED269 (0. 27%)286 (0.29%)NS
Average age ± SD (years)64.5 ± 21.862.8 ± 22.7NS
Age
 20–49 years62 (23.0%)78 (27.2%)NS
 50–64 years42 (15.6%)51 (17.8%)NS
 65–93 years165 (61. 3%)157 (54.9%)NS
Sex
 Female142 (52.8%)142 (49.6%)NS
 Male127 (47.2%)144 (50.4%)NS
Shifts
 Morning (07:00–14:59)118 (43.8%)127 (44. 4%)NS
 Evening (15:00–22:59)118 (43.9%)133 (46.5%)NS
 Night (23:00–06:59)33 (12.3%)26 (9.1% )NS
Length of stay at ED: average ± SD (hours)9.1 ± 5.75.5 ± 4.2<0.0001

Diagnosis and treatment

The abdominal examination was normal in most of the patients in both study periods, and the physical signs were also similar between the groups. A rectal digital examination was performed in 89.6% and 99.3% of the patients in the first and second periods, respectively (P < 0.0001) (). Fecal stones were found in 37 patients and a rectal tumor in five. Hemoglobin, white blood cell count, and creatinine levels were similar in both periods. More X-ray studies were performed in the second period. Paralytic ileus was demonstrated in four patients and was suspected in 12 patients.

Table 2

Signs, symptoms, and laboratory test results

Period 1Period 2P
N269286
Vital signs (mean ± SD)
 Pulse81 ± 1582 ± 16NS
 Fever36. 7 ± 0.336.7 ± 0.4NS
 VAS pain score4.2 ± 3.23.7 ± 3.10.062
Blood pressure
 Systole, mean ± SD138 ± 26138 ± 24NS
 Diastole, mean ± SD72 ± 1573 ± 12NS
Abdominal examination performed in ED265 (98. 5%)286 (100.0%)NS
 Abdominal tenderness17 (6.4%)19 (6.6%)NS
 Abdominal distention16 (6.0%)13 (4.5%)NS
 Suspected incarcerated hernia1 (0.4%)0NS
 Abdominal fullness12 (4. 5%)5 (1.7%)0.095
 Normal abdominal examination223 (84.1%)249 (87.1%)NS
Digital rectal examination performed in ED241 (89.6%)284 (99.3%)<0.0001
 Refused rectal examination6 (2.2%)4 (1.4%)NS
 Fecal stone22 (9. 1%)15 (5.3%)NS
 External hemorrhoids3 (1.2%)5 (1.8%)NS
 Rectal SOL4 (1.6%)1 (0.3%)NS
 Benign prostate hypertrophy2 (0.8%)3 (1.0%)NS
 Normal PR examination232 (96. 3%)258 (90.8%)NS
Blood tests (mean ± SD)
 Hemoglobin12.1 ± 1.412.2 ± 1.6NS
 WBC8596 ± 35438064 ± 2535
 Creatinine0.9 ± 0.50.9 ± 0.3
Abdominal X-ray performed in ED260 (96. 6%)285 (99.56%)0.045
 Paralytic ileus3 (1.1%)1 (0.3%)NS
 Expansion of bowel loops7 (2.7%)5 (1.7%)NS

Cleansing enema was performed in 76.9% and 57.7% of the patients in the first and second period of the study, respectively (P < 0.0001) (). In the first period, only Fleet® Enema (phospho-soda) (Fleet Co, Inc, Lynchburg, VA , USA) was used, and in the second period, this was changed to Easy Go enema (Gilco Pharm Ltd, Rishon Le-Zion, Israel) that is free of sodium and phosphate. Age, renal function, blood pressure, or drugs (including ACE inhibitors and ACE antagonists) were not taken into consideration before treatment with Fleet Enema. A combination therapy of cleansing enema and oral laxative was used in more patients during the first period of study; laxative with no additional enema was used in more patients during the second period.

Table 3

Treatments for constipation in the ED

Period 1Period 2P
N269286
Enema administration in ED207 (76. 9%)165 (57.7%)<0.0001
Enema + PO133 (49.4%)58 (20.2%)<0.0001
Only PO46 (17.1%)85 (29.7%)0.001
Telebrix® (Guerbet, Villepinte, France)39 (14.4%)25 (8.7%)0. 033
Paraffin oil104 (38.7%)89 (31.1%)NS
Avilac (Amvilabs Inc, Atlanta GA, USA)111 (41.2%)92 (32.1%)0.034
Pain killer17 (6.3%)16 (5.6%)NS
No treatment13 (4. 8%)34 (11.9%)0.011

Follow up and outcome

Reassessment before discharge from ED was performed in 79.8% and 99.6% in the first and second period, respectively (P < 0.0001) (). The perforation rate and the 30-day mortality were significantly higher in the first than in the second period studied. The causes of death are given in . One patient in the first period of the study died after Fleet Enema because of hyperphosphatemia and phosphate nephropathy. The rate of return visits was also higher in the first period.

Table 4

Period 1Period 2P
N269286
Reassessment before discharge from ED (out of discharged patients)201 (79. 8%)263 (99.6%)<0.0001
Revisit ED within 1 week for the same reason37 (13.7%)24 (8.4%)<0.0001
Hospitalization15 (5.6%)22 (7.7%)NS
Rectal perforation3 (1.4%)0<0. 0001
30-day mortality8 (3.9%)2 (0.7%)<0.0001

Table 5

Characteristics of patients who died

SexAgePR findingsAbdominal examination findingsX-ray findingsTreatmentReassessment after treatmentDeathComments
Period 1
Female86NormalNormalNot doneFleet® enema (Fleet Co, Inc, Lynchburg, VA, USA)NoWithin 1 dayHyperphosphatemia
Female52Fecal stonesNormalNot doneFleet enema, Avilac (Amvilabs Inc, Atlanta, GA, USA), paraffinYesWithin 1 dayImpaired patient, lost for follow-up
Female76Fecal stonesNormalNot doneFleet enema, Telebrix® (Guerbet, Villepinte, France)YesWithin 5 daysLost for follow-up
Female86NormalInguinal herniaNormalFleet enema, AvilacYesWithin 6 daysLost for follow-up
Female93NormalNormalNormalFleet enema, AvilacPerforationWithin 11 daysImmediate operation
Male86Not doneNormalNormalFleet enemaNoWithin 21 daysPerforation was found at the return visit 3 days after enema administration
Male55NormalInflationNormalFleet enemaNoWithin 3 weeksEnema performed under severe neutropenia. Hospitalization for sepsis 4 days later
Male81NormalNormalNormalFleet enemaYesWithin 1 monthPneumonia
Male72NormalTendernessNot doneFleet enemaNoWithin 3 daysPerforation 9 hours after enema that was performed in another hospital
Period 2
Male64NormalTendernessNormalNo enemaYesWithin 3 weeksEnd-stage cancer
Female89NormalNormalNormalNo enemaYesWithin 1 monthEnd-stage cancer

Clinical guidelines

The guidelines included instructions for diagnosis and the treatment of acute constipation in the ED, the identification of enema risk factors, description of the method of enema administration and follow-up, and recommendation for the specific enema type.

Diagnosis

When acute constipation is suspected, fecal impaction, rectal tumor, and colonic obstruction should be excluded by a compre­hensive abdominal and rectal examination. Drugs and underly­ing diseases that may cause constipation should be excluded. X-ray study is indicated according to the clinical picture.

Treatment

The use of Fleet Enema (phospho-soda) is forbidden due to the danger of hyperphosphatemia and phosphate nephropathy. Cleansing enema should be performed carefully with another product, and the volume should not exceed 250 mL. Administration of the enema is done with a rectal tube, by experienced personnel. Perforation should always be anticipated and suspected if abdominal pain appears. Cleansing enema is contraindicated in patients with fecal stones, rectal obstruction by tumor or rectal prolapse, active coronary heart disease, and in comatose or noncompliant patients. In addition, enema should be avoided in cancer patients under chemotherapy and in other immunocompromised patients, especially those with severe neutropenia.

Follow up and outcome

Before patient discharge from the ED, reassessment of the clinical status should be performed and includes physical abdominal examination and measurement of vital signs. Instructions about adverse events or complications that could occur should be discussed. The patient is instructed to return immediately to the ED if rectal bleeding occurs or if abdominal pains appear.

Discussion

Quality and risk management processes are an essential part of our daily work, in order to improve patient management and safety. We believe that these processes should be based on evidence and good clinical research. In this study, we looked at a very common complaint of constipation, after an anecdotal impression of a high incidence of perforation and mortality.

Constipation is increasingly found in the elderly population and is becoming an important cause of morbidity.13 The constipation rate in the Western world is 2%–28%. 3 Emergency room visits due to acute constipation in the United States are estimated to be 0.22% to 0.36%, very similar to our results.18 Cleansing enema is a popular practice for the treatment of constipation and is used in many patients referred for this reason to the ED.19 Since enema is dispensed as an OTC medication in many countries, many patients arrive at the ED after enema treatment that is not always reported.

In our daily practice we encountered cases of perforation and mortality after cleansing enema but could trace only case reports or small cohort studies in the literature; we could not find any study looking at the incidence of enema complications or adverse events.1017

Two case series from Israel described elderly patients that had perforation after cleansing enema.10,11 Paran et al10 described 13 cases of colon perforation occurring after a cleansing enema performed at home or a nursing home, over a 3-year period, in patients with a mean age of 64. 3 years, similar to our group. Gayer et al11 described 14 cases of rectosigmoid perforations that were picked up from the CT scan database in a period of 6 years. These patients were older, with an average age of 80 years. Since these articles did not mention the total number of patients that were hospitalized during the studies, the incidence could not be calculated.

Because enema is freely available and largely self-administered, with no or little inspection, we could not estimate the true rate of adverse events related to its use. Our study is the first to demonstrate the incidence of adverse events and the 30-day mortality rate after cleansing enema performed by a nurse, in acutely constipated patients treated at an ED. We found three cases of rectal perforation and one case of hyperphosphatemia in the first period of the study compared with no cases in the second period, and this may be due to the new comprehensive guidelines that were established and implemented by the physicians and nurses. The main difference in clinical behavior between the periods of the study was the preference for oral laxatives over enemas and the careful reassessment of the patient prior to discharge, shown in the second period. Of course, we could not separate the role of the enema in causing perforation and mortality from the other potential factors. In addition, we recommended using a flexible rectal tube to overcome the danger of perforation due to the rigid tip of the enema.

Patients presenting to the ED can be demented, have cognitive deficits, or have psychiatric disorder, and in these situations, communication is not optimal and sometimes lacking. Thus, invasive procedures requiring understanding and consent should be avoided as much as possible. Moreover these patients can have a high incidence of fecal impaction and fecal stones, which may cause stercoral ulcers and perforation.16 Perforation, if this occurs, is on a background of a colon full of fecal material and carries a very high risk of peritoneal spilling and peritonitis. The issue of phosphate enema is also important, and we believe this medication should not be used. There are many descriptions of phosphate nephropathy, in addition to the case that occurred in our study.

The limitations of our study arise from being a single center experience and from the lack of clinical information (medical history and medications) about the patients studied. In the ED, the medical history taken is not as comprehensive as for hospitalized patients.

In conclusion, enema for the treatment of acute constipation is not without adverse events, especially in the elderly, and should be applied carefully. Perforation, hyperphosphatemia (after Fleet Enema), and sepsis may occur, causing death in up to 4% of cases. National guidelines for the treatment of acute constipation and for enema administration are urgently needed.

Author contributions

Galia Niv contributed to the study conceptualization, data collection, data analysis, preparation of the manuscript, and was responsible for study supervision; Tamar Grinberg participated in data collection; Nir Waserberg and Ram Dickman participated in study conceptualization, patient management; Yaron Niv contributed to the study conceptualization, data collection, data analysis, preparation of the manuscript, and was responsible for study supervision.

Footnotes

Disclosure

The authors report no conflicts of interest in this work.

References

1. Martin BC, Barghout V, Cerulli A. Davies C. Direct medical costs of constipation in the United States. Manag Care Interface. 2006;19(12):43–49. [PubMed] [Google Scholar]2. Bouras EP, Tangalos EG. Chronic constipation in the elderly. Gastroenterol Clin North Am. 2009;38(3):463–480. [PubMed] [Google Scholar]3. Locke GR, 3rd, Pemberton JH, Phillips SF. AGA technical review on constipation. American Gastroenterological Association. Gastroenterology. 2000;119(6):1766–1778. [PubMed] [Google Scholar]4. Ramakrishnan K, Scheid DC. Enemas: A “Purge” Atory. Internet J Gastroenterol. 2004;3(1) [Google Scholar]5. Davies C. The use of phosphate enemas in the treatment of constipation. Nurs Times. 2004;100(18):32–35. [PubMed] [Google Scholar]6. Ori Y, Rozen-Zvi B, Chagnac A, et al. Fatalities and severe metabolic disorders associated with the use of sodium phosphate enemas: a single center’s experience. Arch Intern Med. 2012;172(3):263–265. [PubMed] [Google Scholar]7. Bobba RK, Arsura EL. Septic shock in an elderly patient on dialysis: enema-induced rectal injury confusing the clinical picture. J Am Geriatr Soc. 2004;52(12):2144. [PubMed] [Google Scholar]8. Knobel B, Petchenko P. Hyperphosphatemic hypocalcemic coma caused by hypertonic sodium phosphate (feet) enema intoxication. J Clin Gastroenterol. 1996;23(3):217–219. [PubMed] [Google Scholar]9. Korzets A, Dicker D, Chaimoff C, Zevin D. Life-threatening hyperphosphatemia and hypocalcemic tetany following the use of feet enemas. J Am Geriatr Soc. 1992;40(6):620–621. [PubMed] [Google Scholar]10. Paran H, Butnaru G, Neufeld D, Magen A, Freund U. Enema-induced perforation of the rectum in chronically constipated patients. Dis Colon Rectum. 1999;42(12):1609–1612. [PubMed] [Google Scholar]11. Gayer G, Zissin R, Apter S, Oscadchy A, Hertz M. Perforations of the rectosigmoid colon induced by cleansing enema: CT findings in 14 patients. Abdom Imaging. 2002;27(4):453–457. [PubMed] [Google Scholar]12. Tanswell IJ, Irfan K, Kossakowski T, Townson G. Rectal perforation in ulcerative colitis: complication of an enema tip. Gastrointest Endosc. 2009;69(2):344. [PubMed] [Google Scholar]13. Saltzstein RJ, Quebbeman E, Melvin JL. Anorectal injuries incident to enema administration. A recurring avoidable problem. Am J Phys Med Rehabil. 1988;67(4):186–188. [PubMed] [Google Scholar]14. Nakamura H, Iyoda M, Sato K, Kitazawa K. Retrograde hydrostatic irrigation enema-induced perforation of the sigmoid colon in a chronic renal failure patient before colonoscopy. J Intern Med Res. 2005;33(6):707–710. [PubMed] [Google Scholar]15. Blatt LJ. Injury of the rectum by tip of disposable enema. Report of a case. Arch Surg. 1960;80:442–444. [PubMed] [Google Scholar]16. Craft L, Prahlow JA. From fecal impaction to colon perforation. Am J Nurse. 2011;111(8):38–43. [PubMed] [Google Scholar]17. Mori H, Kobara H, Fujihara S, et al. Rectal perforations and fistula secondary to a glycerin enema: closure by over-the-scope-clip. World J Gastroenterol. 2012;18(24):3177–3180. [PMC free article] [PubMed] [Google Scholar]18. Shah ND, Chitkara DK, Locke GR, Meek PD, Talley NJ. Ambulatory care for constipation in the United States, 1993–2004. Am J Gastroenterol. 2008;103(7):1746–1753. [PubMed] [Google Scholar]19. Sun SX, Dibonaventura M, Purayidathil FW, Wagner JS, Dabbous O, Mody R. Impact of chronic constipation on health-related quality of life, work productivity, and healthcare resource use: an analysis of the National Health and Wellness Survey. Dig Dis Sci. 2011;56(9):2688–2695. [PubMed] [Google Scholar]

Perforation and mortality after cleansing enema for acute constipation are not rare but are preventable

Int J Gen Med. 2013; 6: 323–328.

Galia Niv

1Risk Management and Quality Assurance, Beilinson Hospital and Tel Aviv University, Tel Aviv, Israel

Tamar Grinberg

2Emergency Department, Beilinson Hospital and Tel Aviv University, Tel Aviv, Israel

Ram Dickman

3Department of Gastroenterology, Beilinson Hospital and Tel Aviv University, Tel Aviv, Israel

Nir Wasserberg

4Department of Surgery B, Rabin Medical Center, Beilinson Hospital and Tel Aviv University, Tel Aviv, Israel

Yaron Niv

1Risk Management and Quality Assurance, Beilinson Hospital and Tel Aviv University, Tel Aviv, Israel

3Department of Gastroenterology, Beilinson Hospital and Tel Aviv University, Tel Aviv, Israel

1Risk Management and Quality Assurance, Beilinson Hospital and Tel Aviv University, Tel Aviv, Israel

2Emergency Department, Beilinson Hospital and Tel Aviv University, Tel Aviv, Israel

3Department of Gastroenterology, Beilinson Hospital and Tel Aviv University, Tel Aviv, Israel

4Department of Surgery B, Rabin Medical Center, Beilinson Hospital and Tel Aviv University, Tel Aviv, Israel

Correspondence to: Yaron Niv, Rabin Medical Center, 39 Jabotinski Street, Petach Tikva, Israel Tel +972 3 937 7328 Fax +972 3 921 0313 Email li.gro.tilalc@vinyCopyright © 2013 Niv et al, publisher and licensee Dove Medical Press Ltd

This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.

This article has been cited by other articles in PMC.

Abstract

Objectives

Constipation is a common complaint, frequently treated with cleansing enema. Enemas can be very effective but may cause serious adverse events, such as perforation or metabolic derangement. Our aim was to evaluate the outcome of the use of cleansing enema for acute constipation and to assess adverse events within 30 days of therapy.

Methods

We performed a two-phase study: an initial retrospective and descriptive study in 2010, followed by a prospective study after intervention, in 2011. According to the results of the first phase we established guidelines for the treatment of constipation in the Emergency Department and then used these in the second phase.

Results

There were 269 and 286 cases of severe constipation in the first and second periods of the study, respectively. In the first study period, only Fleet® Enema was used, and in the second, this was changed to Easy Go enema (free of sodium phosphate). There was a 19.2% decrease in the total use of enema, in the second period of the study (P < 0.0001). Adverse events and especially, the perforation rate and the 30-day mortality in patients with constipation decreased significantly in the second phase: 3 (1.4%) versus 0 (P = 0.0001) and 8 (3.9%) versus 2 (0.7%) (P = 0.0001), for perforation and death in the first and second period of the study, respectively.

Conclusion

Enema for the treatment of acute constipation is not without adverse events, especially in the elderly, and should be applied carefully. Perforation, hyperphosphatemia (after Fleet Enema), and sepsis may cause death in up to 4% of cases. Guidelines for the treatment of acute constipation and for enema administration are urgently needed.

Keywords: phospho-soda, elderly, dementia, obstipation

Introduction

Constipation is a common complaint and is associated with significant health care costs.1 The elderly are five times more prone to constipation than young people, due to the effect of medication, immobility, and blunted urge to defecate.2 Polypharmacy is very frequent among the elderly, and drugs such as pain killers (opiates), antipsychotic, antiparkinson agent, anticholinergic, anxiolytics, calcium, and iron supplements, which are popularly prescribed in the advanced age group, are known to have constipation as a side effect.

Most patients self-medicate to treat constipation, usually with over-the-counter (OTC) drugs, but some need urgent intervention and are referred to the Emergency Department (ED). Many of these patients are demented, have cognitive deficits, or suffer from a psychiatric disorder. The communication between the treating team and these patients may be impaired, and the proper feedback about pain or the side effect of treatments is not optimal.

Acute constipation requires urgent and comprehensive assessment because a serious medical condition may be the underlying cause. A careful medical history, investigation of medications that can cause constipation, and physical examination including rectal examination are important in all patients with severe constipation, in order to define the type of constipation and direct the physician to the correct diagnosis, treatment, and intervention. Rectal examination can assess sphincter tone and tenderness, and may uncover a palpable mass, fissure, or mucosal prolapse.2,3 Even though constipation is a common condition seen in the ED, there has been unequal distribution of knowledge among physicians and nurses regarding this issue, which may explain the wide variance of management and treatment methods for this problem.

Cleansing enema is a popular method for treatment of constipation. The function of enema is dependent on several different mechanisms. By distending the rectum, all enemas stimulate the colon to contract and eliminate stool. Other mechanisms, such as that employing phosphate enemas, directly stimulate the muscles of the colon. Enemas can be very effective but may cause serious adverse events, such as perforation or metabolic derangement.4 Hypertonic sodium phosphate enemas may cause severe phosphate nephropathy, especially in the elderly with chronic renal failure or in patients treated with angiotensin-converting enzyme (ACE) inhibitors.59 Cleansing enema adverse events are rarely reported in the literature but may be life threatening. The most frequent cause of perforation in patients who underwent enema has been reported to be the device tip; other causes are related to localized weakness of the rectal wall, obstruction, or the position of the patient when the enema was performed.1017 We are not aware of any previous study that has looked at the incidence of perforation after enema treatment for acute constipation.

Our aim was to evaluate the outcome of using cleansing enema for severe, acute constipation, in patients referred to the ED of Rabin Medical Center, Beilinson Hospital and to assess the adverse events within 30 days of therapy.

Patients and methods

A retrospective (first phase) study was conducted between January 1, 2010 and December 31, 2010. We studied all the patients that were referred to the ED on an emergency basis because of severe constipation. We included all patients referred, without exclusion.

Patients’ records were reviewed. The data collection included: gender, age, medical history, the results of physical examination, the results of imaging procedures, the type of treatment for constipation, and the outcome assessment, including treatment effectiveness and discharge or hospitalization. We also looked at return visits to the ED within 1 week and 30-day mortality.

A prospective, interventional (second phase) study followed between March 1, 2011 and Feb 29, 2012, using the same methods, after having developed, distributed, and implemented the use of clinical guidelines for the treatment of constipation.

The process of guidelines formation

An expert committee was convened that included experienced physicians from the departments of Surgery, Gastroenterology, Geriatrics, Nephrology, and Emergency Medicine, and experts from the Risk-Management Unit and Pharmacy. The literature was reviewed, and the results of the retrospective study were discussed. Clinical guidelines for the diagnosis and treatment of acute constipation were written and distributed in the medical center. An implementation program was carried out in the ED, over a period of 2 months.

Statistical evaluation

The statistical analysis was performed using SPSS for Windows (version 16.0; IBM, Armonk, NY, USA). Categorical data were described proportionally using descriptive statistics. A difference in proportions was tested by Chi-square statistics, with continuity adjustment or Fisher’s exact test applied where appropriate. The level of significance adopted was 0.05.

Results

Demographic and clinical data

There were 97,500 and 99,000 visits to the ED at Beilinson Hospital, Rabin Medical Center, in the first and second phases of the study, respectively. The number of patients with constipation was similar, 269 (0.27%) and 286 (0.29%), respectively (). Most of the patients were older than 65 years. There was no statistically significant difference in age and gender between the groups. The length of stay in the ED was significantly shorter in the second period of the study.

Table 1

Period 1Period 2P
Number of total ED visits per year97,50099,000
Number of patients with constipation referred to ED269 (0.27%)286 (0.29%)NS
Average age ± SD (years)64.5 ± 21.862.8 ± 22.7NS
Age
 20–49 years62 (23.0%)78 (27.2%)NS
 50–64 years42 (15.6%)51 (17.8%)NS
 65–93 years165 (61.3%)157 (54.9%)NS
Sex
 Female142 (52.8%)142 (49.6%)NS
 Male127 (47.2%)144 (50.4%)NS
Shifts
 Morning (07:00–14:59)118 (43.8%)127 (44.4%)NS
 Evening (15:00–22:59)118 (43.9%)133 (46.5%)NS
 Night (23:00–06:59)33 (12.3%)26 (9.1% )NS
Length of stay at ED: average ± SD (hours)9.1 ± 5.75.5 ± 4.2<0.0001

Diagnosis and treatment

The abdominal examination was normal in most of the patients in both study periods, and the physical signs were also similar between the groups. A rectal digital examination was performed in 89.6% and 99.3% of the patients in the first and second periods, respectively (P < 0.0001) (). Fecal stones were found in 37 patients and a rectal tumor in five. Hemoglobin, white blood cell count, and creatinine levels were similar in both periods. More X-ray studies were performed in the second period. Paralytic ileus was demonstrated in four patients and was suspected in 12 patients.

Table 2

Signs, symptoms, and laboratory test results

Period 1Period 2P
N269286
Vital signs (mean ± SD)
 Pulse81 ± 1582 ± 16NS
 Fever36.7 ± 0.336.7 ± 0.4NS
 VAS pain score4.2 ± 3.23.7 ± 3.10.062
Blood pressure
 Systole, mean ± SD138 ± 26138 ± 24NS
 Diastole, mean ± SD72 ± 1573 ± 12NS
Abdominal examination performed in ED265 (98.5%)286 (100.0%)NS
 Abdominal tenderness17 (6.4%)19 (6.6%)NS
 Abdominal distention16 (6.0%)13 (4.5%)NS
 Suspected incarcerated hernia1 (0.4%)0NS
 Abdominal fullness12 (4.5%)5 (1.7%)0.095
 Normal abdominal examination223 (84.1%)249 (87.1%)NS
Digital rectal examination performed in ED241 (89.6%)284 (99.3%)<0.0001
 Refused rectal examination6 (2.2%)4 (1.4%)NS
 Fecal stone22 (9.1%)15 (5.3%)NS
 External hemorrhoids3 (1.2%)5 (1.8%)NS
 Rectal SOL4 (1.6%)1 (0.3%)NS
 Benign prostate hypertrophy2 (0.8%)3 (1.0%)NS
 Normal PR examination232 (96.3%)258 (90.8%)NS
Blood tests (mean ± SD)
 Hemoglobin12.1 ± 1.412.2 ± 1.6NS
 WBC8596 ± 35438064 ± 2535
 Creatinine0.9 ± 0.50.9 ± 0.3
Abdominal X-ray performed in ED260 (96.6%)285 (99.56%)0.045
 Paralytic ileus3 (1.1%)1 (0.3%)NS
 Expansion of bowel loops7 (2.7%)5 (1.7%)NS

Cleansing enema was performed in 76.9% and 57.7% of the patients in the first and second period of the study, respectively (P < 0.0001) (). In the first period, only Fleet® Enema (phospho-soda) (Fleet Co, Inc, Lynchburg, VA , USA) was used, and in the second period, this was changed to Easy Go enema (Gilco Pharm Ltd, Rishon Le-Zion, Israel) that is free of sodium and phosphate. Age, renal function, blood pressure, or drugs (including ACE inhibitors and ACE antagonists) were not taken into consideration before treatment with Fleet Enema. A combination therapy of cleansing enema and oral laxative was used in more patients during the first period of study; laxative with no additional enema was used in more patients during the second period.

Table 3

Treatments for constipation in the ED

Period 1Period 2P
N269286
Enema administration in ED207 (76.9%)165 (57.7%)<0.0001
Enema + PO133 (49.4%)58 (20.2%)<0.0001
Only PO46 (17.1%)85 (29.7%)0.001
Telebrix® (Guerbet, Villepinte, France)39 (14.4%)25 (8.7%)0.033
Paraffin oil104 (38.7%)89 (31.1%)NS
Avilac (Amvilabs Inc, Atlanta GA, USA)111 (41.2%)92 (32.1%)0.034
Pain killer17 (6.3%)16 (5.6%)NS
No treatment13 (4.8%)34 (11.9%)0.011

Follow up and outcome

Reassessment before discharge from ED was performed in 79.8% and 99.6% in the first and second period, respectively (P < 0.0001) (). The perforation rate and the 30-day mortality were significantly higher in the first than in the second period studied. The causes of death are given in . One patient in the first period of the study died after Fleet Enema because of hyperphosphatemia and phosphate nephropathy. The rate of return visits was also higher in the first period.

Table 4

Period 1Period 2P
N269286
Reassessment before discharge from ED (out of discharged patients)201 (79.8%)263 (99.6%)<0.0001
Revisit ED within 1 week for the same reason37 (13.7%)24 (8.4%)<0.0001
Hospitalization15 (5.6%)22 (7.7%)NS
Rectal perforation3 (1.4%)0<0.0001
30-day mortality8 (3.9%)2 (0.7%)<0.0001

Table 5

Characteristics of patients who died

SexAgePR findingsAbdominal examination findingsX-ray findingsTreatmentReassessment after treatmentDeathComments
Period 1
Female86NormalNormalNot doneFleet® enema (Fleet Co, Inc, Lynchburg, VA, USA)NoWithin 1 dayHyperphosphatemia
Female52Fecal stonesNormalNot doneFleet enema, Avilac (Amvilabs Inc, Atlanta, GA, USA), paraffinYesWithin 1 dayImpaired patient, lost for follow-up
Female76Fecal stonesNormalNot doneFleet enema, Telebrix® (Guerbet, Villepinte, France)YesWithin 5 daysLost for follow-up
Female86NormalInguinal herniaNormalFleet enema, AvilacYesWithin 6 daysLost for follow-up
Female93NormalNormalNormalFleet enema, AvilacPerforationWithin 11 daysImmediate operation
Male86Not doneNormalNormalFleet enemaNoWithin 21 daysPerforation was found at the return visit 3 days after enema administration
Male55NormalInflationNormalFleet enemaNoWithin 3 weeksEnema performed under severe neutropenia. Hospitalization for sepsis 4 days later
Male81NormalNormalNormalFleet enemaYesWithin 1 monthPneumonia
Male72NormalTendernessNot doneFleet enemaNoWithin 3 daysPerforation 9 hours after enema that was performed in another hospital
Period 2
Male64NormalTendernessNormalNo enemaYesWithin 3 weeksEnd-stage cancer
Female89NormalNormalNormalNo enemaYesWithin 1 monthEnd-stage cancer

Clinical guidelines

The guidelines included instructions for diagnosis and the treatment of acute constipation in the ED, the identification of enema risk factors, description of the method of enema administration and follow-up, and recommendation for the specific enema type.

Diagnosis

When acute constipation is suspected, fecal impaction, rectal tumor, and colonic obstruction should be excluded by a compre­hensive abdominal and rectal examination. Drugs and underly­ing diseases that may cause constipation should be excluded. X-ray study is indicated according to the clinical picture.

Treatment

The use of Fleet Enema (phospho-soda) is forbidden due to the danger of hyperphosphatemia and phosphate nephropathy. Cleansing enema should be performed carefully with another product, and the volume should not exceed 250 mL. Administration of the enema is done with a rectal tube, by experienced personnel. Perforation should always be anticipated and suspected if abdominal pain appears. Cleansing enema is contraindicated in patients with fecal stones, rectal obstruction by tumor or rectal prolapse, active coronary heart disease, and in comatose or noncompliant patients. In addition, enema should be avoided in cancer patients under chemotherapy and in other immunocompromised patients, especially those with severe neutropenia.

Follow up and outcome

Before patient discharge from the ED, reassessment of the clinical status should be performed and includes physical abdominal examination and measurement of vital signs. Instructions about adverse events or complications that could occur should be discussed. The patient is instructed to return immediately to the ED if rectal bleeding occurs or if abdominal pains appear.

Discussion

Quality and risk management processes are an essential part of our daily work, in order to improve patient management and safety. We believe that these processes should be based on evidence and good clinical research. In this study, we looked at a very common complaint of constipation, after an anecdotal impression of a high incidence of perforation and mortality.

Constipation is increasingly found in the elderly population and is becoming an important cause of morbidity.13 The constipation rate in the Western world is 2%–28%.3 Emergency room visits due to acute constipation in the United States are estimated to be 0.22% to 0.36%, very similar to our results.18 Cleansing enema is a popular practice for the treatment of constipation and is used in many patients referred for this reason to the ED.19 Since enema is dispensed as an OTC medication in many countries, many patients arrive at the ED after enema treatment that is not always reported.

In our daily practice we encountered cases of perforation and mortality after cleansing enema but could trace only case reports or small cohort studies in the literature; we could not find any study looking at the incidence of enema complications or adverse events.1017

Two case series from Israel described elderly patients that had perforation after cleansing enema.10,11 Paran et al10 described 13 cases of colon perforation occurring after a cleansing enema performed at home or a nursing home, over a 3-year period, in patients with a mean age of 64.3 years, similar to our group. Gayer et al11 described 14 cases of rectosigmoid perforations that were picked up from the CT scan database in a period of 6 years. These patients were older, with an average age of 80 years. Since these articles did not mention the total number of patients that were hospitalized during the studies, the incidence could not be calculated.

Because enema is freely available and largely self-administered, with no or little inspection, we could not estimate the true rate of adverse events related to its use. Our study is the first to demonstrate the incidence of adverse events and the 30-day mortality rate after cleansing enema performed by a nurse, in acutely constipated patients treated at an ED. We found three cases of rectal perforation and one case of hyperphosphatemia in the first period of the study compared with no cases in the second period, and this may be due to the new comprehensive guidelines that were established and implemented by the physicians and nurses. The main difference in clinical behavior between the periods of the study was the preference for oral laxatives over enemas and the careful reassessment of the patient prior to discharge, shown in the second period. Of course, we could not separate the role of the enema in causing perforation and mortality from the other potential factors. In addition, we recommended using a flexible rectal tube to overcome the danger of perforation due to the rigid tip of the enema.

Patients presenting to the ED can be demented, have cognitive deficits, or have psychiatric disorder, and in these situations, communication is not optimal and sometimes lacking. Thus, invasive procedures requiring understanding and consent should be avoided as much as possible. Moreover these patients can have a high incidence of fecal impaction and fecal stones, which may cause stercoral ulcers and perforation.16 Perforation, if this occurs, is on a background of a colon full of fecal material and carries a very high risk of peritoneal spilling and peritonitis. The issue of phosphate enema is also important, and we believe this medication should not be used. There are many descriptions of phosphate nephropathy, in addition to the case that occurred in our study.

The limitations of our study arise from being a single center experience and from the lack of clinical information (medical history and medications) about the patients studied. In the ED, the medical history taken is not as comprehensive as for hospitalized patients.

In conclusion, enema for the treatment of acute constipation is not without adverse events, especially in the elderly, and should be applied carefully. Perforation, hyperphosphatemia (after Fleet Enema), and sepsis may occur, causing death in up to 4% of cases. National guidelines for the treatment of acute constipation and for enema administration are urgently needed.

Author contributions

Galia Niv contributed to the study conceptualization, data collection, data analysis, preparation of the manuscript, and was responsible for study supervision; Tamar Grinberg participated in data collection; Nir Waserberg and Ram Dickman participated in study conceptualization, patient management; Yaron Niv contributed to the study conceptualization, data collection, data analysis, preparation of the manuscript, and was responsible for study supervision.

Footnotes

Disclosure

The authors report no conflicts of interest in this work.

References

1. Martin BC, Barghout V, Cerulli A. Davies C. Direct medical costs of constipation in the United States. Manag Care Interface. 2006;19(12):43–49. [PubMed] [Google Scholar]2. Bouras EP, Tangalos EG. Chronic constipation in the elderly. Gastroenterol Clin North Am. 2009;38(3):463–480. [PubMed] [Google Scholar]3. Locke GR, 3rd, Pemberton JH, Phillips SF. AGA technical review on constipation. American Gastroenterological Association. Gastroenterology. 2000;119(6):1766–1778. [PubMed] [Google Scholar]4. Ramakrishnan K, Scheid DC. Enemas: A “Purge” Atory. Internet J Gastroenterol. 2004;3(1) [Google Scholar]5. Davies C. The use of phosphate enemas in the treatment of constipation. Nurs Times. 2004;100(18):32–35. [PubMed] [Google Scholar]6. Ori Y, Rozen-Zvi B, Chagnac A, et al. Fatalities and severe metabolic disorders associated with the use of sodium phosphate enemas: a single center’s experience. Arch Intern Med. 2012;172(3):263–265. [PubMed] [Google Scholar]7. Bobba RK, Arsura EL. Septic shock in an elderly patient on dialysis: enema-induced rectal injury confusing the clinical picture. J Am Geriatr Soc. 2004;52(12):2144. [PubMed] [Google Scholar]8. Knobel B, Petchenko P. Hyperphosphatemic hypocalcemic coma caused by hypertonic sodium phosphate (feet) enema intoxication. J Clin Gastroenterol. 1996;23(3):217–219. [PubMed] [Google Scholar]9. Korzets A, Dicker D, Chaimoff C, Zevin D. Life-threatening hyperphosphatemia and hypocalcemic tetany following the use of feet enemas. J Am Geriatr Soc. 1992;40(6):620–621. [PubMed] [Google Scholar]10. Paran H, Butnaru G, Neufeld D, Magen A, Freund U. Enema-induced perforation of the rectum in chronically constipated patients. Dis Colon Rectum. 1999;42(12):1609–1612. [PubMed] [Google Scholar]11. Gayer G, Zissin R, Apter S, Oscadchy A, Hertz M. Perforations of the rectosigmoid colon induced by cleansing enema: CT findings in 14 patients. Abdom Imaging. 2002;27(4):453–457. [PubMed] [Google Scholar]12. Tanswell IJ, Irfan K, Kossakowski T, Townson G. Rectal perforation in ulcerative colitis: complication of an enema tip. Gastrointest Endosc. 2009;69(2):344. [PubMed] [Google Scholar]13. Saltzstein RJ, Quebbeman E, Melvin JL. Anorectal injuries incident to enema administration. A recurring avoidable problem. Am J Phys Med Rehabil. 1988;67(4):186–188. [PubMed] [Google Scholar]14. Nakamura H, Iyoda M, Sato K, Kitazawa K. Retrograde hydrostatic irrigation enema-induced perforation of the sigmoid colon in a chronic renal failure patient before colonoscopy. J Intern Med Res. 2005;33(6):707–710. [PubMed] [Google Scholar]15. Blatt LJ. Injury of the rectum by tip of disposable enema. Report of a case. Arch Surg. 1960;80:442–444. [PubMed] [Google Scholar]16. Craft L, Prahlow JA. From fecal impaction to colon perforation. Am J Nurse. 2011;111(8):38–43. [PubMed] [Google Scholar]17. Mori H, Kobara H, Fujihara S, et al. Rectal perforations and fistula secondary to a glycerin enema: closure by over-the-scope-clip. World J Gastroenterol. 2012;18(24):3177–3180. [PMC free article] [PubMed] [Google Scholar]18. Shah ND, Chitkara DK, Locke GR, Meek PD, Talley NJ. Ambulatory care for constipation in the United States, 1993–2004. Am J Gastroenterol. 2008;103(7):1746–1753. [PubMed] [Google Scholar]19. Sun SX, Dibonaventura M, Purayidathil FW, Wagner JS, Dabbous O, Mody R. Impact of chronic constipation on health-related quality of life, work productivity, and healthcare resource use: an analysis of the National Health and Wellness Survey. Dig Dis Sci. 2011;56(9):2688–2695. [PubMed] [Google Scholar]

Perforation and mortality after cleansing enema for acute constipation are not rare but are preventable

Int J Gen Med. 2013; 6: 323–328.

Galia Niv

1Risk Management and Quality Assurance, Beilinson Hospital and Tel Aviv University, Tel Aviv, Israel

Tamar Grinberg

2Emergency Department, Beilinson Hospital and Tel Aviv University, Tel Aviv, Israel

Ram Dickman

3Department of Gastroenterology, Beilinson Hospital and Tel Aviv University, Tel Aviv, Israel

Nir Wasserberg

4Department of Surgery B, Rabin Medical Center, Beilinson Hospital and Tel Aviv University, Tel Aviv, Israel

Yaron Niv

1Risk Management and Quality Assurance, Beilinson Hospital and Tel Aviv University, Tel Aviv, Israel

3Department of Gastroenterology, Beilinson Hospital and Tel Aviv University, Tel Aviv, Israel

1Risk Management and Quality Assurance, Beilinson Hospital and Tel Aviv University, Tel Aviv, Israel

2Emergency Department, Beilinson Hospital and Tel Aviv University, Tel Aviv, Israel

3Department of Gastroenterology, Beilinson Hospital and Tel Aviv University, Tel Aviv, Israel

4Department of Surgery B, Rabin Medical Center, Beilinson Hospital and Tel Aviv University, Tel Aviv, Israel

Correspondence to: Yaron Niv, Rabin Medical Center, 39 Jabotinski Street, Petach Tikva, Israel Tel +972 3 937 7328 Fax +972 3 921 0313 Email li.gro.tilalc@vinyCopyright © 2013 Niv et al, publisher and licensee Dove Medical Press Ltd

This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.

This article has been cited by other articles in PMC.

Abstract

Objectives

Constipation is a common complaint, frequently treated with cleansing enema. Enemas can be very effective but may cause serious adverse events, such as perforation or metabolic derangement. Our aim was to evaluate the outcome of the use of cleansing enema for acute constipation and to assess adverse events within 30 days of therapy.

Methods

We performed a two-phase study: an initial retrospective and descriptive study in 2010, followed by a prospective study after intervention, in 2011. According to the results of the first phase we established guidelines for the treatment of constipation in the Emergency Department and then used these in the second phase.

Results

There were 269 and 286 cases of severe constipation in the first and second periods of the study, respectively. In the first study period, only Fleet® Enema was used, and in the second, this was changed to Easy Go enema (free of sodium phosphate). There was a 19.2% decrease in the total use of enema, in the second period of the study (P < 0.0001). Adverse events and especially, the perforation rate and the 30-day mortality in patients with constipation decreased significantly in the second phase: 3 (1.4%) versus 0 (P = 0.0001) and 8 (3.9%) versus 2 (0.7%) (P = 0.0001), for perforation and death in the first and second period of the study, respectively.

Conclusion

Enema for the treatment of acute constipation is not without adverse events, especially in the elderly, and should be applied carefully. Perforation, hyperphosphatemia (after Fleet Enema), and sepsis may cause death in up to 4% of cases. Guidelines for the treatment of acute constipation and for enema administration are urgently needed.

Keywords: phospho-soda, elderly, dementia, obstipation

Introduction

Constipation is a common complaint and is associated with significant health care costs.1 The elderly are five times more prone to constipation than young people, due to the effect of medication, immobility, and blunted urge to defecate.2 Polypharmacy is very frequent among the elderly, and drugs such as pain killers (opiates), antipsychotic, antiparkinson agent, anticholinergic, anxiolytics, calcium, and iron supplements, which are popularly prescribed in the advanced age group, are known to have constipation as a side effect.

Most patients self-medicate to treat constipation, usually with over-the-counter (OTC) drugs, but some need urgent intervention and are referred to the Emergency Department (ED). Many of these patients are demented, have cognitive deficits, or suffer from a psychiatric disorder. The communication between the treating team and these patients may be impaired, and the proper feedback about pain or the side effect of treatments is not optimal.

Acute constipation requires urgent and comprehensive assessment because a serious medical condition may be the underlying cause. A careful medical history, investigation of medications that can cause constipation, and physical examination including rectal examination are important in all patients with severe constipation, in order to define the type of constipation and direct the physician to the correct diagnosis, treatment, and intervention. Rectal examination can assess sphincter tone and tenderness, and may uncover a palpable mass, fissure, or mucosal prolapse.2,3 Even though constipation is a common condition seen in the ED, there has been unequal distribution of knowledge among physicians and nurses regarding this issue, which may explain the wide variance of management and treatment methods for this problem.

Cleansing enema is a popular method for treatment of constipation. The function of enema is dependent on several different mechanisms. By distending the rectum, all enemas stimulate the colon to contract and eliminate stool. Other mechanisms, such as that employing phosphate enemas, directly stimulate the muscles of the colon. Enemas can be very effective but may cause serious adverse events, such as perforation or metabolic derangement.4 Hypertonic sodium phosphate enemas may cause severe phosphate nephropathy, especially in the elderly with chronic renal failure or in patients treated with angiotensin-converting enzyme (ACE) inhibitors.59 Cleansing enema adverse events are rarely reported in the literature but may be life threatening. The most frequent cause of perforation in patients who underwent enema has been reported to be the device tip; other causes are related to localized weakness of the rectal wall, obstruction, or the position of the patient when the enema was performed.1017 We are not aware of any previous study that has looked at the incidence of perforation after enema treatment for acute constipation.

Our aim was to evaluate the outcome of using cleansing enema for severe, acute constipation, in patients referred to the ED of Rabin Medical Center, Beilinson Hospital and to assess the adverse events within 30 days of therapy.

Patients and methods

A retrospective (first phase) study was conducted between January 1, 2010 and December 31, 2010. We studied all the patients that were referred to the ED on an emergency basis because of severe constipation. We included all patients referred, without exclusion.

Patients’ records were reviewed. The data collection included: gender, age, medical history, the results of physical examination, the results of imaging procedures, the type of treatment for constipation, and the outcome assessment, including treatment effectiveness and discharge or hospitalization. We also looked at return visits to the ED within 1 week and 30-day mortality.

A prospective, interventional (second phase) study followed between March 1, 2011 and Feb 29, 2012, using the same methods, after having developed, distributed, and implemented the use of clinical guidelines for the treatment of constipation.

The process of guidelines formation

An expert committee was convened that included experienced physicians from the departments of Surgery, Gastroenterology, Geriatrics, Nephrology, and Emergency Medicine, and experts from the Risk-Management Unit and Pharmacy. The literature was reviewed, and the results of the retrospective study were discussed. Clinical guidelines for the diagnosis and treatment of acute constipation were written and distributed in the medical center. An implementation program was carried out in the ED, over a period of 2 months.

Statistical evaluation

The statistical analysis was performed using SPSS for Windows (version 16.0; IBM, Armonk, NY, USA). Categorical data were described proportionally using descriptive statistics. A difference in proportions was tested by Chi-square statistics, with continuity adjustment or Fisher’s exact test applied where appropriate. The level of significance adopted was 0.05.

Results

Demographic and clinical data

There were 97,500 and 99,000 visits to the ED at Beilinson Hospital, Rabin Medical Center, in the first and second phases of the study, respectively. The number of patients with constipation was similar, 269 (0.27%) and 286 (0.29%), respectively (). Most of the patients were older than 65 years. There was no statistically significant difference in age and gender between the groups. The length of stay in the ED was significantly shorter in the second period of the study.

Table 1

Period 1Period 2P
Number of total ED visits per year97,50099,000
Number of patients with constipation referred to ED269 (0.27%)286 (0.29%)NS
Average age ± SD (years)64.5 ± 21.862.8 ± 22.7NS
Age
 20–49 years62 (23.0%)78 (27.2%)NS
 50–64 years42 (15.6%)51 (17.8%)NS
 65–93 years165 (61.3%)157 (54.9%)NS
Sex
 Female142 (52.8%)142 (49.6%)NS
 Male127 (47.2%)144 (50.4%)NS
Shifts
 Morning (07:00–14:59)118 (43.8%)127 (44.4%)NS
 Evening (15:00–22:59)118 (43.9%)133 (46.5%)NS
 Night (23:00–06:59)33 (12.3%)26 (9.1% )NS
Length of stay at ED: average ± SD (hours)9.1 ± 5.75.5 ± 4.2<0.0001

Diagnosis and treatment

The abdominal examination was normal in most of the patients in both study periods, and the physical signs were also similar between the groups. A rectal digital examination was performed in 89.6% and 99.3% of the patients in the first and second periods, respectively (P < 0.0001) (). Fecal stones were found in 37 patients and a rectal tumor in five. Hemoglobin, white blood cell count, and creatinine levels were similar in both periods. More X-ray studies were performed in the second period. Paralytic ileus was demonstrated in four patients and was suspected in 12 patients.

Table 2

Signs, symptoms, and laboratory test results

Period 1Period 2P
N269286
Vital signs (mean ± SD)
 Pulse81 ± 1582 ± 16NS
 Fever36.7 ± 0.336.7 ± 0.4NS
 VAS pain score4.2 ± 3.23.7 ± 3.10.062
Blood pressure
 Systole, mean ± SD138 ± 26138 ± 24NS
 Diastole, mean ± SD72 ± 1573 ± 12NS
Abdominal examination performed in ED265 (98.5%)286 (100.0%)NS
 Abdominal tenderness17 (6.4%)19 (6.6%)NS
 Abdominal distention16 (6.0%)13 (4.5%)NS
 Suspected incarcerated hernia1 (0.4%)0NS
 Abdominal fullness12 (4.5%)5 (1.7%)0.095
 Normal abdominal examination223 (84.1%)249 (87.1%)NS
Digital rectal examination performed in ED241 (89.6%)284 (99.3%)<0.0001
 Refused rectal examination6 (2.2%)4 (1.4%)NS
 Fecal stone22 (9.1%)15 (5.3%)NS
 External hemorrhoids3 (1.2%)5 (1.8%)NS
 Rectal SOL4 (1.6%)1 (0.3%)NS
 Benign prostate hypertrophy2 (0.8%)3 (1.0%)NS
 Normal PR examination232 (96.3%)258 (90.8%)NS
Blood tests (mean ± SD)
 Hemoglobin12.1 ± 1.412.2 ± 1.6NS
 WBC8596 ± 35438064 ± 2535
 Creatinine0.9 ± 0.50.9 ± 0.3
Abdominal X-ray performed in ED260 (96.6%)285 (99.56%)0.045
 Paralytic ileus3 (1.1%)1 (0.3%)NS
 Expansion of bowel loops7 (2.7%)5 (1.7%)NS

Cleansing enema was performed in 76.9% and 57.7% of the patients in the first and second period of the study, respectively (P < 0.0001) (). In the first period, only Fleet® Enema (phospho-soda) (Fleet Co, Inc, Lynchburg, VA , USA) was used, and in the second period, this was changed to Easy Go enema (Gilco Pharm Ltd, Rishon Le-Zion, Israel) that is free of sodium and phosphate. Age, renal function, blood pressure, or drugs (including ACE inhibitors and ACE antagonists) were not taken into consideration before treatment with Fleet Enema. A combination therapy of cleansing enema and oral laxative was used in more patients during the first period of study; laxative with no additional enema was used in more patients during the second period.

Table 3

Treatments for constipation in the ED

Period 1Period 2P
N269286
Enema administration in ED207 (76.9%)165 (57.7%)<0.0001
Enema + PO133 (49.4%)58 (20.2%)<0.0001
Only PO46 (17.1%)85 (29.7%)0.001
Telebrix® (Guerbet, Villepinte, France)39 (14.4%)25 (8.7%)0.033
Paraffin oil104 (38.7%)89 (31.1%)NS
Avilac (Amvilabs Inc, Atlanta GA, USA)111 (41.2%)92 (32.1%)0.034
Pain killer17 (6.3%)16 (5.6%)NS
No treatment13 (4.8%)34 (11.9%)0.011

Follow up and outcome

Reassessment before discharge from ED was performed in 79.8% and 99.6% in the first and second period, respectively (P < 0.0001) (). The perforation rate and the 30-day mortality were significantly higher in the first than in the second period studied. The causes of death are given in . One patient in the first period of the study died after Fleet Enema because of hyperphosphatemia and phosphate nephropathy. The rate of return visits was also higher in the first period.

Table 4

Period 1Period 2P
N269286
Reassessment before discharge from ED (out of discharged patients)201 (79.8%)263 (99.6%)<0.0001
Revisit ED within 1 week for the same reason37 (13.7%)24 (8.4%)<0.0001
Hospitalization15 (5.6%)22 (7.7%)NS
Rectal perforation3 (1.4%)0<0.0001
30-day mortality8 (3.9%)2 (0.7%)<0.0001

Table 5

Characteristics of patients who died

SexAgePR findingsAbdominal examination findingsX-ray findingsTreatmentReassessment after treatmentDeathComments
Period 1
Female86NormalNormalNot doneFleet® enema (Fleet Co, Inc, Lynchburg, VA, USA)NoWithin 1 dayHyperphosphatemia
Female52Fecal stonesNormalNot doneFleet enema, Avilac (Amvilabs Inc, Atlanta, GA, USA), paraffinYesWithin 1 dayImpaired patient, lost for follow-up
Female76Fecal stonesNormalNot doneFleet enema, Telebrix® (Guerbet, Villepinte, France)YesWithin 5 daysLost for follow-up
Female86NormalInguinal herniaNormalFleet enema, AvilacYesWithin 6 daysLost for follow-up
Female93NormalNormalNormalFleet enema, AvilacPerforationWithin 11 daysImmediate operation
Male86Not doneNormalNormalFleet enemaNoWithin 21 daysPerforation was found at the return visit 3 days after enema administration
Male55NormalInflationNormalFleet enemaNoWithin 3 weeksEnema performed under severe neutropenia. Hospitalization for sepsis 4 days later
Male81NormalNormalNormalFleet enemaYesWithin 1 monthPneumonia
Male72NormalTendernessNot doneFleet enemaNoWithin 3 daysPerforation 9 hours after enema that was performed in another hospital
Period 2
Male64NormalTendernessNormalNo enemaYesWithin 3 weeksEnd-stage cancer
Female89NormalNormalNormalNo enemaYesWithin 1 monthEnd-stage cancer

Clinical guidelines

The guidelines included instructions for diagnosis and the treatment of acute constipation in the ED, the identification of enema risk factors, description of the method of enema administration and follow-up, and recommendation for the specific enema type.

Diagnosis

When acute constipation is suspected, fecal impaction, rectal tumor, and colonic obstruction should be excluded by a compre­hensive abdominal and rectal examination. Drugs and underly­ing diseases that may cause constipation should be excluded. X-ray study is indicated according to the clinical picture.

Treatment

The use of Fleet Enema (phospho-soda) is forbidden due to the danger of hyperphosphatemia and phosphate nephropathy. Cleansing enema should be performed carefully with another product, and the volume should not exceed 250 mL. Administration of the enema is done with a rectal tube, by experienced personnel. Perforation should always be anticipated and suspected if abdominal pain appears. Cleansing enema is contraindicated in patients with fecal stones, rectal obstruction by tumor or rectal prolapse, active coronary heart disease, and in comatose or noncompliant patients. In addition, enema should be avoided in cancer patients under chemotherapy and in other immunocompromised patients, especially those with severe neutropenia.

Follow up and outcome

Before patient discharge from the ED, reassessment of the clinical status should be performed and includes physical abdominal examination and measurement of vital signs. Instructions about adverse events or complications that could occur should be discussed. The patient is instructed to return immediately to the ED if rectal bleeding occurs or if abdominal pains appear.

Discussion

Quality and risk management processes are an essential part of our daily work, in order to improve patient management and safety. We believe that these processes should be based on evidence and good clinical research. In this study, we looked at a very common complaint of constipation, after an anecdotal impression of a high incidence of perforation and mortality.

Constipation is increasingly found in the elderly population and is becoming an important cause of morbidity.13 The constipation rate in the Western world is 2%–28%.3 Emergency room visits due to acute constipation in the United States are estimated to be 0.22% to 0.36%, very similar to our results.18 Cleansing enema is a popular practice for the treatment of constipation and is used in many patients referred for this reason to the ED.19 Since enema is dispensed as an OTC medication in many countries, many patients arrive at the ED after enema treatment that is not always reported.

In our daily practice we encountered cases of perforation and mortality after cleansing enema but could trace only case reports or small cohort studies in the literature; we could not find any study looking at the incidence of enema complications or adverse events.1017

Two case series from Israel described elderly patients that had perforation after cleansing enema.10,11 Paran et al10 described 13 cases of colon perforation occurring after a cleansing enema performed at home or a nursing home, over a 3-year period, in patients with a mean age of 64.3 years, similar to our group. Gayer et al11 described 14 cases of rectosigmoid perforations that were picked up from the CT scan database in a period of 6 years. These patients were older, with an average age of 80 years. Since these articles did not mention the total number of patients that were hospitalized during the studies, the incidence could not be calculated.

Because enema is freely available and largely self-administered, with no or little inspection, we could not estimate the true rate of adverse events related to its use. Our study is the first to demonstrate the incidence of adverse events and the 30-day mortality rate after cleansing enema performed by a nurse, in acutely constipated patients treated at an ED. We found three cases of rectal perforation and one case of hyperphosphatemia in the first period of the study compared with no cases in the second period, and this may be due to the new comprehensive guidelines that were established and implemented by the physicians and nurses. The main difference in clinical behavior between the periods of the study was the preference for oral laxatives over enemas and the careful reassessment of the patient prior to discharge, shown in the second period. Of course, we could not separate the role of the enema in causing perforation and mortality from the other potential factors. In addition, we recommended using a flexible rectal tube to overcome the danger of perforation due to the rigid tip of the enema.

Patients presenting to the ED can be demented, have cognitive deficits, or have psychiatric disorder, and in these situations, communication is not optimal and sometimes lacking. Thus, invasive procedures requiring understanding and consent should be avoided as much as possible. Moreover these patients can have a high incidence of fecal impaction and fecal stones, which may cause stercoral ulcers and perforation.16 Perforation, if this occurs, is on a background of a colon full of fecal material and carries a very high risk of peritoneal spilling and peritonitis. The issue of phosphate enema is also important, and we believe this medication should not be used. There are many descriptions of phosphate nephropathy, in addition to the case that occurred in our study.

The limitations of our study arise from being a single center experience and from the lack of clinical information (medical history and medications) about the patients studied. In the ED, the medical history taken is not as comprehensive as for hospitalized patients.

In conclusion, enema for the treatment of acute constipation is not without adverse events, especially in the elderly, and should be applied carefully. Perforation, hyperphosphatemia (after Fleet Enema), and sepsis may occur, causing death in up to 4% of cases. National guidelines for the treatment of acute constipation and for enema administration are urgently needed.

Author contributions

Galia Niv contributed to the study conceptualization, data collection, data analysis, preparation of the manuscript, and was responsible for study supervision; Tamar Grinberg participated in data collection; Nir Waserberg and Ram Dickman participated in study conceptualization, patient management; Yaron Niv contributed to the study conceptualization, data collection, data analysis, preparation of the manuscript, and was responsible for study supervision.

Footnotes

Disclosure

The authors report no conflicts of interest in this work.

References

1. Martin BC, Barghout V, Cerulli A. Davies C. Direct medical costs of constipation in the United States. Manag Care Interface. 2006;19(12):43–49. [PubMed] [Google Scholar]2. Bouras EP, Tangalos EG. Chronic constipation in the elderly. Gastroenterol Clin North Am. 2009;38(3):463–480. [PubMed] [Google Scholar]3. Locke GR, 3rd, Pemberton JH, Phillips SF. AGA technical review on constipation. American Gastroenterological Association. Gastroenterology. 2000;119(6):1766–1778. [PubMed] [Google Scholar]4. Ramakrishnan K, Scheid DC. Enemas: A “Purge” Atory. Internet J Gastroenterol. 2004;3(1) [Google Scholar]5. Davies C. The use of phosphate enemas in the treatment of constipation. Nurs Times. 2004;100(18):32–35. [PubMed] [Google Scholar]6. Ori Y, Rozen-Zvi B, Chagnac A, et al. Fatalities and severe metabolic disorders associated with the use of sodium phosphate enemas: a single center’s experience. Arch Intern Med. 2012;172(3):263–265. [PubMed] [Google Scholar]7. Bobba RK, Arsura EL. Septic shock in an elderly patient on dialysis: enema-induced rectal injury confusing the clinical picture. J Am Geriatr Soc. 2004;52(12):2144. [PubMed] [Google Scholar]8. Knobel B, Petchenko P. Hyperphosphatemic hypocalcemic coma caused by hypertonic sodium phosphate (feet) enema intoxication. J Clin Gastroenterol. 1996;23(3):217–219. [PubMed] [Google Scholar]9. Korzets A, Dicker D, Chaimoff C, Zevin D. Life-threatening hyperphosphatemia and hypocalcemic tetany following the use of feet enemas. J Am Geriatr Soc. 1992;40(6):620–621. [PubMed] [Google Scholar]10. Paran H, Butnaru G, Neufeld D, Magen A, Freund U. Enema-induced perforation of the rectum in chronically constipated patients. Dis Colon Rectum. 1999;42(12):1609–1612. [PubMed] [Google Scholar]11. Gayer G, Zissin R, Apter S, Oscadchy A, Hertz M. Perforations of the rectosigmoid colon induced by cleansing enema: CT findings in 14 patients. Abdom Imaging. 2002;27(4):453–457. [PubMed] [Google Scholar]12. Tanswell IJ, Irfan K, Kossakowski T, Townson G. Rectal perforation in ulcerative colitis: complication of an enema tip. Gastrointest Endosc. 2009;69(2):344. [PubMed] [Google Scholar]13. Saltzstein RJ, Quebbeman E, Melvin JL. Anorectal injuries incident to enema administration. A recurring avoidable problem. Am J Phys Med Rehabil. 1988;67(4):186–188. [PubMed] [Google Scholar]14. Nakamura H, Iyoda M, Sato K, Kitazawa K. Retrograde hydrostatic irrigation enema-induced perforation of the sigmoid colon in a chronic renal failure patient before colonoscopy. J Intern Med Res. 2005;33(6):707–710. [PubMed] [Google Scholar]15. Blatt LJ. Injury of the rectum by tip of disposable enema. Report of a case. Arch Surg. 1960;80:442–444. [PubMed] [Google Scholar]16. Craft L, Prahlow JA. From fecal impaction to colon perforation. Am J Nurse. 2011;111(8):38–43. [PubMed] [Google Scholar]17. Mori H, Kobara H, Fujihara S, et al. Rectal perforations and fistula secondary to a glycerin enema: closure by over-the-scope-clip. World J Gastroenterol. 2012;18(24):3177–3180. [PMC free article] [PubMed] [Google Scholar]18. Shah ND, Chitkara DK, Locke GR, Meek PD, Talley NJ. Ambulatory care for constipation in the United States, 1993–2004. Am J Gastroenterol. 2008;103(7):1746–1753. [PubMed] [Google Scholar]19. Sun SX, Dibonaventura M, Purayidathil FW, Wagner JS, Dabbous O, Mody R. Impact of chronic constipation on health-related quality of life, work productivity, and healthcare resource use: an analysis of the National Health and Wellness Survey. Dig Dis Sci. 2011;56(9):2688–2695. [PubMed] [Google Scholar]

Deadly Enema | HEALTH: Medicine | HEALTH

Several years ago, a rather unusual procedure became fashionable – intestinal lavage using a special apparatus. In fact, the process is somewhat reminiscent of setting an enema, but not a traditional rubber bulb is used for it, but a special high-tech apparatus. The bowel lavage procedure even received a special name – colon hydrotherapy. The popularity of this new product turned out to be so high that at first the clinics that bought such a device did not know the end of their clients.

Now the fashion for high-tech enema has passed, but this procedure has remained its followers. The main argument in favor of this procedure was that under the influence of large volumes of water, a huge amount of toxins are removed from the intestines, which, allegedly, cannot leave the digestive system on their own. Official medicine was loyal to this procedure, ranking it rather as an unconventional treatment than some kind of panacea.

But some citizens approached the hydrocolonotherapy fanatically and became regular visitors to the clinics where this service is provided.More recently, the results of American scientists were published, which say that colon hydrotherapy is not as useful as it was believed, moreover, it can harm the human body. There is no benefit from colon hydrotherapy, but it is full of side effects that can be fatal, doctors say. Study head Renit Mishori of Georgetown University School of Medicine has reviewed 20 papers on enemas over the past 10 years. She came to the conclusion that enemas bring very little benefit compared to the enormous harm that can be attributed to bowel lavage.Water flushes beneficial microflora out of the gut, which can lead to acute kidney failure, vomiting, seizures, and lazy bowel syndrome.

She believes that colon hydrotherapy in the United States is carried out by doctors without the necessary specialty. Therefore, enema procedures have become so popular lately. They can be made in literally every “medical” center and spa. At the same time, the list of diseases that an enema saves from is huge: here and cleansing from toxins, weight loss, cellulite, poor immunity.To useless “cleansing procedures”, the researchers also attributed the use of laxatives and laxative teas. Certain herbal teas for bowel cleansing have caused aplastic anemia and liver dysfunction. – Do you want to feel good? Eat a proper diet, exercise, sleep 6-8 hours and see your doctor regularly, advises Mishori. Based on the materials of the American therapeutic journal “The Journal of Family Practice”.

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Coffee is known to have health benefits, but drinking coffee isn’t the only way to get an antioxidant boost.Coffee liquid enemas may sound strange, but research suggests that such enemas are an effective way to cleanse the intestines and promote health.

Coffee enemas help remove bacteria, heavy metals, fungus and yeast (causing candidiasis, for example) from the gastrointestinal tract, liver and colon, as well as relieve inflammation, improve bowel function, cope with illness and gain strength.

Before you give up on this idea, consider that various natural detoxification methods, including enemas, have been used to normalize bowel function and promote health for thousands of years.Some of them are even mentioned in ancient manuscripts such as the Dead Sea Scrolls, which describe how Jesus used natural materials to heal diseases.

What is a coffee enema?

A coffee enema is a natural way to cleanse the body by injecting coffee diluted with water into the anus and colon. Despite the fact that this method is not known, it is far from new. Recently, the use of enemas, fecal microbiota transplantation and other methods of unconventional bowel treatment are gaining popularity, as more and more people understand that laxatives and other drugs cannot cope with the root cause of the disorder.

Coffee enemas were used heavily in the late 1800s to speed recovery from surgery or to treat accidental poisoning. In the 1950s, the Gerson Institute pioneered the use of coffee enemas as part of a natural cancer therapy. Nowadays it is used for a variety of reasons, in particular, when the effectiveness of traditional treatment or prescription drugs is low.

Today, functional and alternative medicine doctors use coffee enemas to treat the following ailments:

  • Cancer
  • Parasites
  • Overdose
  • Constipation
  • Liver dysfunction
  • Fungal virus
  • SRK
  • Indigestion

How Coffee Enemas Work

The Gerson Institute states that the main purpose of coffee enemas is to “remove toxins from the liver and rid the blood of free radicals.”And it’s not just the caffeine itself. Research suggests that the bioavailability of caffeine from coffee enemas is 3.5 times less than oral coffee intake.

It is known that coffee beans, in addition to caffeine, contain antioxidants and useful compounds such as cafeestol palmitate, caveol, theobromine, and theophylline. They help relieve inflammation, including in the digestive system.

When ingested, the compounds in coffee act as a laxative, causing the muscles in the colon to contract and aiding in the elimination of stools.

Regular bowel movements help eliminate toxins and other harmful substances (heavy metals and excess fatty acids) from the body. Research has shown that when coffee enemas are administered, caffeine and other substances pass through the hemorrhoidal vein to the liver. Coffee opens up blood vessels, relaxes smooth muscles, promoting bowel movements and improving circulation. Once in the liver, coffee helps open the bile ducts and increase the production of bile necessary for proper digestion and excretion.

Scientists at the University of Minnesota in the US also say the benefits of coffee enemas may include stimulating the liver’s production of the enzyme glutathione S-transferase, an antioxidant that cleans the blood and fights inflammation. There is evidence that coffee enemas help:

  • Restore digestive tissues
  • Cleanse the liver
  • Improve blood circulation
  • Strengthen immunity
  • Increase cellular regeneration
  • Cope with digestive disorders (frequent constipation, bloating, cramps, nausea)
  • Improve bowel health
  • Improve mood and energize

Health Benefits

1.Increases the activity of antioxidants

Coffee enemas are thought to increase the production of glutathione S-transferase. Functional medicine practitioner and pharmacist Susie Cohen talks about the practical value of getting enough glutathione S-transferase from the body, given the price of supplements.

The enzyme’s importance lies in its ability to scavenge free radicals (which cause inflammation, bowel disorders, liver disease, and cellular damage) in the digestive tract.Bile, produced by the liver and gallbladder, removes the neutralized radicals from the body through the intestines.

2. Helps fight cancer

Max Gerson, physician and author of The Treatment of Malignant Formations , published in 1958, has successfully used coffee enemas on thousands of cancer patients. Dr. Gerson introduced coffee enemas as a natural treatment for cancer and detoxification, making them part of anti-inflammatory therapy combined with nutritional supplements.

The US National Cancer Institute claims that an organic vegetarian diet, combined with pancreatic enzymes and coffee enemas, is the mainstay of Gerson’s therapy to support the immune system in cancer patients and restore electrolyte balance (such as potassium levels in cells). The introduction of several coffee enemas a day (up to six) has helped many patients to avoid pain relievers, normalize liver function and facilitate tissue repair.

3. Promotes detoxification

Cleansing with coffee enemas (similar to blood dialysis) helps get rid of unwanted compounds in the intestinal walls and in the blood. Dialysis is considered a forced or artificial method to accelerate detoxification, which is facilitated by a coffee enema. The main function of the enema is to mechanically cleanse the colon, removing possible harmful parasites, bacteria, yeast and heavy metals that can cause inflammation and then disease.

There is some evidence that coffee can act as a natural astringent; it helps the top layer of the skin or the lining of the digestive tract to cleanse and rejuvenate (similar to how tightening face masks promote cell renewal). Some scientists believe that the upper mucous layer on the surface of the intestine is capable of accumulating large amounts of toxins. Thus, regular bowel cleansing protects against the development of the disease.

In addition to caffeine, the water used for the enema also has a therapeutic effect. Hydrotherapy, or hydrotherapy, helps the body cleanse the colon and rectum by promoting regular bowel movements.

4. Relieves constipation

Constipation is a very common problem among adults, which is why laxatives are among the best-selling drugs. If you have problems with stool, then you will be glad to know that coffee enemas can naturally cure this ailment.First, the water injected into the colon not only stimulates peristalsis, but also increases the production of bile.

The mechanical effect of the enema causes the large intestine to work actively, promoting the elimination of stools along with toxins and food debris that provoke constipation. Coffee can also help treat colon diverticulitis, damage to the walls where food particles or bacteria can accumulate.

Do coffee enemas help in weight loss? They help relieve inflammation, bloating and excess fluid.However, it is important to remember that enemas cannot replace a healthy and balanced diet. The best results can be achieved by combining coffee enemas with drinking plenty of water and adjusting the diet (avoiding foods that cause inflammation: sugar, white flour, hydrogenated fats that slow down digestion).

How to use

Coffee enemas are easy and affordable, they can be used in your own bathroom (or any other place that is comfortable for you).All you need is fresh coffee beans and an enema kit:

  • An enema kit can be purchased at the pharmacy or online. They are very diverse: from simple “camping” sets to reusable and stationary. It is important that your kit includes a tip tubing attached to the reservoir. This set can be used while lying down.
  • After purchasing the set, you need to purchase coffee beans. Choose organic, caffeinated beans.It is important that they do not contain any “extra” chemical compounds that can interfere with detoxification.
  • Finally, if you already have inflammation or distress, you can start giving an enema. Some people recommend storing grains in the freezer to preserve maximum antioxidants.

It is best to do an enema immediately after a bowel movement (if possible), in this case it will be as comfortable and effective as possible.

How to apply a coffee enema?

Some practitioners recommend using activated charcoal before and after administering a coffee enema.Dr. Jay Davidson recommends the use of BioTox adsorbent, which helps to bind toxins and eliminate them from the body.

For bowel disorders, practitioners recommend using from one enema per week to one daily. For serious illnesses (such as cancer), patients are advised to do several enemas a day. In this case, it will be more economical (and more environmentally friendly) to use a reusable injection kit.

Having prepared all the necessary materials, you can start preparing a safe solution for an enema:

  1. Add coffee beans to the pot of purified water.It is important to use clean water, without the addition of impurities and chemicals. For 3 cups of water, take 2 tablespoons of organic coffee beans. Bring water to a boil and cook for 15 minutes.
  2. Allow the mixture to cool to room temperature. Strain the liquid to remove the grains. It is very important that the liquid is well cooled, in this case the risk of damage and side effects is significantly reduced.
  3. Before giving the enema, choose a place where you can lie down for 15 minutes.Most patients prefer to use the bathroom. Place the container of liquid at least 1 meter above you, so gravity will help the coffee solution to enter your intestines more quickly.
  4. Pour fluid into reservoir, keep valve closed. Secure the tubing and valve to help stop the flow. Lubricate the tip with oil before starting to facilitate insertion. Lie on the right side in the embryo position and insert the tip into the anus about 2 cm.
  5. Open the valve, all liquid from the reservoir should enter the intestines. After this procedure, it is necessary to retain the solution in itself for 12-15 minutes, this is enough for the enema to have its therapeutic effect.

Side effects

Not all experts are sure that enemas (both coffee and any other) are necessary for intestinal problems. They believe that the body must get rid of toxins and bacteria on its own, and any intervention can only harm.

Why are coffee enemas dangerous? The Institute of Digestive and Nutritional Diseases at Korea University studied the effects of coffee enemas on their patients and reported that they usually do not experience any complications or side effects. Coffee enemas are considered safe and justifiable for treating intestinal disorders without clinically significant adverse effects. However, as with other treatments, the results are individual.

Why are coffee enemas dangerous?

If enemas have previously caused you any concerns, then before using coffee enemas, we recommend that you consult with a specialist.The first session should be carried out under the supervision or guidance of a medical professional, so you can be sure that you have prepared the solution correctly and carried out the procedure safely.

It is worth noting that all enemas have side effects (especially if they were not administered correctly), which can include ruptured colon, dehydration, and electrolyte imbalances. To avoid unpleasant consequences, always use a lubricant, insert the tip slowly, and follow all instructions carefully.Cool the solution well to prevent burns and irritation. Due to possible hypersensitivity to caffeine, we do not recommend administering coffee enemas to children and pregnant women.

If you have suffered / are suffering from hemorrhoids or ruptures, then the insertion of the nozzle can be painful, so the procedure should be abandoned. Also, do not use enemas more than once a week until you are convinced that you have no symptoms of dehydration: dizziness, muscle cramps, weakness as a result of frequent bowel movements.Drink plenty of water to help detoxify.

The US National Cancer Institute reports at least three deaths associated with coffee enemas. Despite the fact that these cases have been recorded over a long period of time (several decades), they should not be forgotten. Coffee enemas can be especially dangerous for patients with coffee allergies and should always be kept in mind before performing the procedure.

Final conclusions

  • Coffee Enema is a natural colon cleanse that involves injecting a coffee solution into the rectum and colon.
  • Coffee enemas have been used since the 1800s to help fight cancer, parasites, overdose symptoms, bloating, constipation, liver dysfunction, fungal virus, IBS and other bowel disorders.
  • Coffee enemas can increase the amount of antioxidants in the body, improve digestion, help cleanse and promote liver health.
  • Coffee enemas, like all enemas in general, have their pros and cons.In addition to their beneficial properties, enemas can cause dehydration, allergic reactions, and ruptures in the colon.

You can make an appointment with an oncologist on our website.

90,000 Treatment of intestinal intussusception in children

Review Question

What is the best treatment for intestinal intussusception in children?

Relevance

Intestinal intussusception is an emergency that occurs in children when one section of the intestine, like a telescope, “folds” into another part of the intestine.This causes pain, vomiting, and intestinal obstruction, which interferes with the passage of intestinal contents. If untreated, intestinal perforation may occur, as a result of which its contents are poured into the abdominal cavity, which leads to the development of complications in the future. In rare cases, this can lead to death. Rapid diagnosis and treatment reduces the risks of intussusception and the need for surgery.

Once the diagnosis of intussusception has been made, most clinicians agree on prescribing an enema as a starting treatment.This procedure consists of injecting a substance (air or liquid) into the intestine, through the rectum under a certain pressure, which straightens the “telescopic” intestine into its normal position.

There is ongoing controversy over specific details as to what type of substance should be used for the enema, how to visualize this substance during the process, whether additional drugs should be given to enhance therapy, and how to deal with treatment failure, and which approach is best for surgery. treatment of intestinal intussusception in children.

Characteristics of research

Evidence is current to September 2016. We identified six randomized trials involving 822 children that examined the treatment of intussusception and evaluated different types of interventions. We also identified three ongoing clinical trials.

Main results

The main outcome was the number of children with successful bowel expansion. Also, outcomes included the number of children presenting with re-intussusception and the estimated harm (adverse events) from the intervention.

Evidence from two studies suggests that an air enema is more effective in reducing intussusception than a liquid enema. Evidence from two studies also suggests that steroid use in a child with intussusception, such as dexamethasone, can reduce the rate of recurrence of intussusception, whether the enema is air or liquid.

We found rather scant information about intraoperative and postoperative complications and other adverse events.

Quality of evidence

We believe that all six identified trials could potentially be biased due to the lack of details on how each study was conducted. We found inconsistencies in the definition and measurement of outcomes. For all the included studies, there were serious concerns about inaccuracies based on a small number of events, a wide range of confidence intervals, or a high risk of bias. Overall, we concluded that the quality of the evidence presented in these studies was low, and the actual effect may differ significantly from that observed in these studies.

Further research is needed to help clinicians better understand the most effective treatment for intussusception in children.

CLISM FOR A CHILD – IPM Clinic for Children in Krasnoyarsk

However, even despite the simplicity of this procedure, to achieve an effective result, it must be carried out with great responsibility so as not to damage the baby’s delicate intestines. It should be noted that you should not get carried away with enemas, and carry out procedures only in cases of extreme necessity, when all known methods have been tried, but to no avail.If stool disorders occur in a child too often, it is necessary to identify and treat the cause of their occurrence. In addition, small children simply need to control the abdominal press on their own without assistance.

Types of enemas and rules for their implementation
An enema is a procedure for injecting fluid into the rectum for diagnosis or treatment. Depending on the effect that must be obtained, enemas are subdivided into:

Cleansing – their purpose is to free the intestines from gases and feces.Depending on the age of the child, enemas are carried out in different volumes: for newborns – 25 ml, at the age of 1-2 months – 30-40 ml, for babies 2-3 months – 50 ml, 2-4 months – 60 ml, at 6 months – 75- 100 ml, 6-9 months – 100-120 ml, 9-12 months – 120-180 ml, at 1 year -150 ml, from 1 to 2 years – 200-250 ml, from 2 to 5 years – 300 ml, from 5 to 9 years old – 400 ml, over 10 years old – 0.5 l. The liquid for the enema should be at a temperature not lower than 28 and not higher than 38 degrees.

Medicinal – they are made only as prescribed by doctors in order to influence medications on the intestinal lining.The temperature of the liquid for the enema should be 40-41 ° C. As a rule, by means of this kind of enemas, the baby is injected with a decoction of chamomile in cases of flatulence, a 2% solution of chloral hydrate (for convulsions), antibiotics in the form of a suspension in warm fish oil, rosehip oil or sea buckthorn (with colitis, with frequent vomiting) and some other medicines. Healing enemas are given after cleansing.

Nutrients – used most often for persistent vomiting. As a rule, weak glucose solutions and saline solutions are injected.

Oily – as a laxative for children. Sunflower, hemp or liquid paraffin heated to body temperature is injected into the rectum. The effect is achieved approximately after 8-10 hours, so this type of enema is best set at night. In rare cases, such enemas are used in cases of inflammation in the large intestine.

Conducting an enema for infants

Before the procedure, wash your hands thoroughly with soap and water. To carry out a cleansing enema, children (babies, babies) must first be sterilized by boiling a rubber balloon for half an hour.As an enema, babies are injected with boiled water at a temperature slightly lower than the child’s body temperature (for older children, you can use cooler water). Then fill the balloon with the required volume of water, depending on the age of the baby, and grease the tip of the balloon thoroughly with petroleum jelly or vegetable oil. After that, it is necessary to lay an oilcloth, and on top of a diaper, on which to lay on the child’s back and raise the legs up to the stomach, bending them at the knees. Older children (1-6 years old) are laid on their left side, and the legs are pulled to the stomach.After that, pushing the buttocks apart, very carefully insert the tip of the balloon into the rectum, having previously released the air from it. The soft and short tip must be inserted completely, harder and longer – to a depth of 4-5 cm. After inserting the tip, slowly squeeze the balloon to introduce water into the intestine. The fluid should be injected while the child inhales. If the child begins to cry, the introduction of water should be temporarily suspended. As soon as the required volume of fluid is introduced into the child’s intestines, the tip is slowly removed without unclenching.After that, the child’s buttocks must be squeezed with both hands and held for about a minute so that the liquid remains in the body for as long as possible. Then the child can be turned first on one side, then on the other, on the stomach, which will allow the liquid to be distributed throughout the intestines.

After the completion of the procedure, the child must be washed. After use, the balloon itself is thoroughly washed, boiled, dried and stored in a sealed container.

In case of atonic constipation (lack of intestinal tone), the recommended temperature of the injected fluid should be 18-20 ° C or even lower, and in case of spastic constipation (excessive intestinal motility) – 37-38 ° C.To enhance the effect of the enema, it is allowed to add a little (1 tsp) of glycerin or vegetable oil to the injected water.

An enema should be given to a child during the first three years of life only with the permission of a doctor. After all, frequent constipation or unexplained abdominal pain can be signs of acute appendicitis, volvulus, pneumonia, infringement of an internal hernia and some other serious diseases. The use of an enema on its own can only be in cases of the need to lower body temperature in highly febrile sick children, and also when it is known for sure that constipation in a child is caused by mistakes in nutrition.

Conducting an enema for older children.

To carry out a cleansing enema in children over five years old, an Esmarch mug is used, with a volume significantly exceeding the balloon (1.5-2 liters). The child is laid on the left side, with the legs drawn to the stomach. Esmarch’s mug, having previously released the air by opening the tap, is filled with boiled water at a temperature of 20-22 degrees Celsius. The mug itself is hung on a special tripod at a distance of 50-75 cm from the child. The tip is also lubricated with petroleum jelly or oil and, spreading the buttocks slightly, gradually, without pressure, enter it into the intestine.At the beginning, it should be inserted a short distance forward towards the navel, then back, parallel to the coccyx, to a depth of 5-10 cm. The rate of fluid flow can be adjusted by means of a special clamp or a tap placed on a rubber tube. After the enema, the child must remove the tip and let the baby lie down for ten minutes, preferably turning over, until there is a desire to empty the intestines.

Contraindications for enema.

Enemas in order to cleanse the child’s body are contraindicated in cases of suspicion of acute appendicitis, intestinal bleeding, intestinal obstruction, inflammation in the anus and other surgical diseases, as well as in rectal prolapse and in the first days after surgery on the abdominal organs.

In cases where the enema did not give the desired result, do not be afraid. Water that has been injected into the intestines is not harmful to health. You can repeat the procedure after six hours.

HIV-related questions and answers

Date added: October 19, 2018

Every year, about 2 million new cases of HIV infection are registered, that is, more than five thousand people are infected every day, one in twenty of them is Russian. Depressing enough information, isn’t it? If you live in the Russian Federation, then I have worse news – on average, the growth rate of infected people increases by 5% every year. And, in Russia, the same figure is much higher – 12.5%.The growth rate is twice as large, so be careful, and we will tell you the myths that people believe in even in the 21st century.

1. I am not a drug addict, I am heterosexual and therefore do not belong to the risk group. I am not afraid of HIV.

When they first learned about HIV, there was a very popular opinion that only men with non-traditional forms of sexual intercourse are infected with this infection. and already in the early 90s they began to register cases of infection through injecting drugs.

It’s bad luck, but already now half of all HIV-infected people are heterosexual people – men and women 20–35 years old.often women become infected from their first sexual partners, and already men, as statistics show on the means of promiscuity and injecting drugs.

There is, although rather low, the likelihood of nosocomial HIV infection.

2. Infection with HIV is a death sentence.

No and no again. Infection with the human immunodeficiency virus does not mean a quick death. With timely initiation of treatment and adherence to the regimen of antiretroviral drugs, HIV-positive patients have every chance of a long and as active life as other people.

3. If a person has HIV, then he is sick and AIDS.

HIV and AIDS are not synonymous. Receiving a positive HIV test result indicates only one thing – you are a carrier of the human immunodeficiency virus. AIDS – Acquired Immunodeficiency Syndrome – is a late stage of HIV infection that does not develop in all patients. Proper treatment, regular visits to a doctor and monitoring your health will help you notice a weakened immune system in a timely manner and prevent the development of AIDS.

4. They die not from HIV, but from AIDS or other infections, and HIV has nothing to do with it.

HIV destroys the immune system, so the stronger the virus, the weaker the body.

5. I have a clean partner.

Purity and HIV are not related. HIV is found in blood, and in smaller amounts in semen, vaginal secretions, and breast milk. It doesn’t wash off in the shower.

What’s more, brushing your teeth, douching or using an enema even increases your risk of contracting HIV through unprotected contact.

6. I feel fine, I cannot have HIV.

The period when the virus is already in the body, but antibodies have not yet been detected, is called the “seronegative window”. During the “window” period, the HIV test will be negative, but at this time the virus is intensively multiplying and the infected person is especially dangerous for infecting other people.

Unfortunately, well-being is not an absolute indicator of health. HIV in the acute stage, when treatment gives the best results, can pretend to have a high fever, or it can show itself poorly at all, many will not notice the ailment.

Six months after infection, the infection becomes chronic; in some, it lasts for years without clinical manifestations.

I hope you have identified useful information for yourself and understood that HIV infection is a serious disease and should be checked often and without fear.

Children suffered from a cleansing enema, which was mistakenly filled with formalin solution instead of water

03/07/2016

Two nurses participated in the preparation for the operation of three young patients: one prepared the solution for enemas, the other performed the manipulation prescribed by the doctor.While preparing the solution, the first nurse made a gross mistake – she did not look at the inscription on the bottle and instead of the bottle with saline she took liquid from the bottle with formalin. As a result, one boy died 3 hours after the procedure, while others developed severe intoxication, which required intensive treatment in the intensive care unit. Fortunately, these children survived.

None of us are immune from such a mistake: it is human nature to make mistakes. That is why a set of security measures has been invented to prevent errors that have high risks for the health and life of patients.The most important of the measures is to carefully check the inscriptions on ampoules, vials, packages, etc. before use in a patient. The inscriptions must be read carefully, checking the name and dose (concentration of solutions).

In this case, the error became possible, since for some unknown reason a bottle of formalin was found among the bottles with saline. When checking the pharmacy that makes solutions for the hospital where the tragedy occurred, a lot of violations of the manufacture and storage of drugs were revealed.It cannot be ruled out that under such conditions a bottle with a poisonous substance could get into a container with a bottle containing a physiological solution. The error was not found during the posting of the vials in the hospital, when they were issued to the department, and finally, when they were issued to the post.

Thus, the pharmacy and the hospital did not have a proper pharmacological order, one of the points of which should be a ban on the use of vials and other containers for poisonous substances that are used for drugs.Recognizing gross violations in the organization of drug supply, the chief physician resigned of his own free will. Meanwhile, the “extreme” were two nurses: a criminal case was opened against them.

A source


Sigmoidoscopy

Diagnostic sigmoidoscopy with sampling of biopsy material.

Sigmoidoscopy is an endoscopic examination of the mucous membrane of the sigmoid and rectum with a number of diagnostic and therapeutic procedures under the control of a special device – a rectoscope.

Readings:

  • suspicion of a neoplasm, ulcer, inflammation in the rectum
  • persistent constipation or diarrhea
  • hemorrhoids (to clarify the state of internal hemorrhoids)
  • as a treatment procedure for the removal of small benign lesions in the rectum

Contraindications:

  • general serious condition of the patient
  • acute inflammatory and suppurative lesions of the anus

Preparation for examination is similar to preparation for colonoscopy (slag-free diet, cleansing with enemas, use of laxatives)

Research Procedure:

The procedure is practically painless, so no pain relief is required.Sigmoidoscopy is performed in the knee-elbow position of the patient, sometimes in the supine position on the left side. The rectoscope is carefully inserted to a depth of 4 – 5 cm, then a small amount of air is pumped in in order to straighten the folds of the rectal mucosa. The doctor examines the condition of the intestinal mucosa in detail on the monitor screen, where the image from the rectoscope is fed. If necessary, it is possible to take a biopsy of the altered part of the intestine for examination or to remove the polyp.

Duration of sigmoidoscopy is approximately 15 minutes.

Sigmoidoscopy risks and safety:

There are practically no complications. Possible undesirable consequences – perforation of the rectum. Highly qualified endoscopists minimize risk.

Registration for research:

It is necessary to agree in advance on the day and time of the study by phone: 268-78-36

If you are unable to appear at the appointed time, please call the department in advance!

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