Rubus idaeus medicinal use: Relaxant activity of raspberry (Rubus idaeus) leaf extract in guinea-pig ileum in vitro
Relaxant activity of raspberry (Rubus idaeus) leaf extract in guinea-pig ileum in vitro
. 2002 Nov;16(7):665-8.
doi: 10.1002/ptr.1040.
Janne Rojas-Vera
1
, Asmita V Patel, Christopher G Dacke
Affiliations
Affiliation
- 1 School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, PO1 2DT, UK.
PMID:
12410549
DOI:
10.1002/ptr.1040
Janne Rojas-Vera et al.
Phytother Res.
2002 Nov.
. 2002 Nov;16(7):665-8.
doi: 10.1002/ptr.1040.
Authors
Janne Rojas-Vera
1
, Asmita V Patel, Christopher G Dacke
Affiliation
- 1 School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, PO1 2DT, UK.
PMID:
12410549
DOI:
10.1002/ptr.1040
Abstract
Tea made from the leaves of Rubus idaeus L. (raspberry) has been used for centuries as a folk medicine to treat wounds, diarrhoea, colic pain and as a uterine relaxant. Extracts of dried raspberry leaves prepared with different solvents, (n-hexane, ethyl acetate, chloroform and methanol) were tested in vitro for relaxant activity on transmurally stimulated guinea-pig ileum. The methanol (MeOH) extract exhibited the largest response and also indicated that the active compounds are of a relatively polar nature. Hence the bulk of the leaves were extracted with methanol and the dried extract fractionated on a silica gel column, eluting with chloroform, mixtures of chloroform and methanol and finally methanol. Each fraction was examined by thin layer chromatography and tested for relaxant activity in an in vitro transmurally stimulated guinea-pig ileum preparation. The fractions eluted with chloroform (CHCl(3)) lacked relaxant activity. Samples eluted with CHCl(3)/MeOH (95:5) had moderate relaxant activity, while a second distinctive peak of activity eluted with a more polar solvent mixture (CHCl(3)/MeOH 50:50) provided strong dose dependent responses. Evidence was obtained that there are at least two components of raspberry leaf extract which exhibit relaxant activity in an in vitro gastrointestinal preparation.
Copyright 2002 John Wiley & Sons, Ltd.
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Publication types
MeSH terms
Substances
Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews
Overview
Red raspberry (Rubus idaeus) plant produces the widely eaten, sweet fruit. Red raspberry fruit and leaf have been used as medicine for centuries.
The chemicals in red raspberry might have antioxidant effects and help relax blood vessels. They might also cause muscles to contract or relax, depending on the dose and the muscle involved. This is the theory behind red raspberry’s use in easing labor and delivery.
People use red raspberry for labor, diarrhea, diabetes, and many other purposes, but there is no good scientific evidence to support these uses.
Don’t confuse red raspberry with black raspberry, blackberry, or raspberry ketone.
Uses & Effectiveness ?
Possibly Ineffective for
Side Effects
When taken by mouth: Red raspberry fruit is commonly consumed as a food. It is possibly safe when taken in larger amounts as medicine. Red raspberry fruit is usually well-tolerated. There isn’t enough reliable information to know if red raspberry leaf is safe or what the side effects might be.
Special Precautions and Warnings
When taken by mouth: Red raspberry fruit is commonly consumed as a food. It is possibly safe when taken in larger amounts as medicine. Red raspberry fruit is usually well-tolerated. There isn’t enough reliable information to know if red raspberry leaf is safe or what the side effects might be. Pregnancy: Red raspberry fruit is commonly consumed as a food. Red raspberry leaf is possibly safe when taken by mouth as medicine during LATE pregnancy under the direct supervision of a healthcare provider. But don’t take it on your own. It is likely unsafe to take red raspberry leaf as a medicine earlier in pregnancy. It might act like the hormone estrogen. This might harm the pregnancy.
Breast-feeding: Red raspberry fruit is commonly consumed as a food. There isn’t enough reliable information to know if it is safe to take red raspberry leaf when breast-feeding. Stay on the safe side and avoid use.
Hormone-sensitive conditions such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Red raspberry leaf might act like estrogen. If you have any condition that might be sensitive to estrogen, don’t use red raspberry leaf.
Interactions ?
Insulin decreases blood sugar levels in the body.
Red raspberry leaf might also decrease blood sugar levels in the body. Taking raspberry leaf along with insulin might cause blood sugar levels in the body to be too low. Monitor your blood sugar closely. The dose of your insulin might need to be changed.
Red raspberry leaf might slow blood clotting. Taking red raspberry leaf along with medications that also slow blood clotting might increase the risk of bruising and bleeding.
Moderate Interaction
Be cautious with this combination
Dosing
Red raspberry fruit is commonly eaten on its own and processed into jams and other foods.
As medicine, there isn’t enough reliable information to know what an appropriate dose of red raspberry fruit or leaf might be. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.
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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.
This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.
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Description Biennial shrub of the Rosaceae family 1. Pharmacological and medical properties Berries contain sugars, organic acids (malic, |