What are the potential benefits of taking 50000 IU vitamin D weekly. How can high-dose vitamin D supplementation affect bone health and immune function. What side effects and risks should be considered when taking large doses of vitamin D.

Understanding Vitamin D and High-Dose Supplementation

Vitamin D is a fat-soluble nutrient crucial for bone health, immune function, and overall well-being. While our bodies can produce vitamin D through sun exposure, many individuals don’t get enough from sunlight alone, leading to the use of supplements. One such supplement is the high-dose 50000 IU vitamin D3 taken weekly.

This dosage is significantly higher than the recommended daily intake of 600-800 IU for most adults. It’s typically prescribed by healthcare providers to address specific health concerns or severe vitamin D deficiencies.

How does vitamin D work in the body?

Vitamin D plays a vital role in calcium absorption, helping to maintain strong bones and teeth. It also supports immune function, muscle health, and may have effects on mood regulation. When vitamin D enters the body, it’s converted into an active form that can be used by various tissues and organs.

Potential Benefits of 50000 IU Vitamin D3 Weekly

High-dose vitamin D supplementation may offer several potential benefits, although more research is needed to fully understand its effects. Some possible advantages include:

• Enhanced bone health and reduced risk of osteoporosis
• Decreased risk of falls and fractures in older adults
• Improved immune system function
• Potential reduction in the risk of certain cancers
• Possible improvement in mood and reduction of anxiety and depression symptoms

Can high-dose vitamin D improve cardiovascular health?

While some studies suggest a potential link between vitamin D and cardiovascular health, the evidence is mixed. More research is needed to determine if high-dose vitamin D supplementation can directly benefit heart health.

Side Effects Associated with 50000 IU Vitamin D3 Weekly

Despite the potential benefits, high-dose vitamin D supplementation can lead to side effects, especially if taken without proper medical supervision. Common side effects may include:

1. Nausea and vomiting
2. Constipation or diarrhea
3. Weakness and fatigue
4. Headache
5. Loss of appetite
6. Increased thirst and urination

In rare cases, long-term use of high-dose vitamin D may lead to kidney damage. It’s crucial to consult with a healthcare provider before starting any high-dose supplement regimen.

How quickly do side effects of high-dose vitamin D appear?

The onset of side effects can vary among individuals. Some people may experience symptoms shortly after beginning supplementation, while others might not notice any adverse effects for weeks or months. Regular monitoring by a healthcare provider is essential when taking high-dose vitamin D.

Risks and Precautions of High-Dose Vitamin D Supplementation

While vitamin D is generally considered safe, taking high doses can increase the risk of certain health problems. Potential risks associated with 50000 IU vitamin D3 weekly include:

• Hypercalcemia (excessive calcium levels in the blood)
• Formation of kidney stones
• Increased risk of heart disease
• Potential increased risk of stroke
• Possible increased risk of certain types of cancer

It’s important to note that these risks are primarily associated with long-term use of high doses without proper medical supervision.

Who should avoid high-dose vitamin D supplements?

Certain individuals should be cautious about taking high-dose vitamin D supplements, including:

• People with kidney disease or a history of kidney stones
• Individuals with high blood calcium levels
• Those taking certain medications that interact with vitamin D
• Pregnant or breastfeeding women (without medical supervision)

Proper Dosing and Administration of 50000 IU Vitamin D3

The appropriate dosage of vitamin D can vary depending on individual factors such as age, weight, skin color, and overall health status. While 50000 IU weekly is a common prescription dose, it’s crucial to follow your healthcare provider’s recommendations.

How should 50000 IU vitamin D3 be taken?

Typically, 50000 IU vitamin D3 is taken once a week, usually in the form of a capsule or tablet. It’s often recommended to take the supplement with a meal containing some fat to enhance absorption. Always follow the specific instructions provided by your healthcare provider or pharmacist.

Monitoring Vitamin D Levels and Adjusting Supplementation

Regular monitoring of vitamin D levels through blood tests is essential when taking high-dose supplements. This allows healthcare providers to adjust the dosage as needed and ensure that levels remain within a safe and effective range.

How often should vitamin D levels be checked when taking high doses?

The frequency of vitamin D level checks can vary based on individual circumstances. Generally, healthcare providers may recommend testing every 3-6 months when starting high-dose supplementation, with less frequent monitoring once levels stabilize. Always follow your healthcare provider’s recommendations for testing frequency.

Alternatives to High-Dose Vitamin D Supplementation

While high-dose vitamin D supplementation may be necessary for some individuals, there are alternatives for maintaining adequate vitamin D levels:

• Regular, safe sun exposure
• Consuming vitamin D-rich foods (fatty fish, egg yolks, fortified dairy products)
• Lower-dose daily vitamin D supplements
• Combination calcium and vitamin D supplements

Can dietary changes alone provide sufficient vitamin D?

For most people, it’s challenging to get enough vitamin D through diet alone. While incorporating vitamin D-rich foods can help, many individuals still benefit from some form of supplementation or increased sun exposure to maintain optimal levels.

The Importance of Professional Medical Advice

Before starting any high-dose vitamin D regimen, it’s crucial to consult with a healthcare provider. They can assess your individual needs, potential risks, and determine if high-dose supplementation is appropriate for you.

What questions should I ask my healthcare provider about vitamin D supplementation?

When discussing vitamin D supplementation with your healthcare provider, consider asking:

• What is my current vitamin D level?
• Is high-dose supplementation necessary for my situation?
• What potential interactions might occur with my current medications?
• How long will I need to take high-dose supplements?
• What signs of vitamin D toxicity should I watch for?

By engaging in an open dialogue with your healthcare provider, you can ensure that you’re taking the most appropriate and safe approach to maintaining optimal vitamin D levels.

Side Effects, Benefits, and Risks

If you’re looking to boost your vitamin D levels, you may have heard about taking 50000 IU vitamin D3 weekly. But is it safe? What are the potential side effects, benefits, and risks? In this blog post, we’ll explore everything you need to know about this high-dose vitamin D supplement.

What is Vitamin D?

Vitamin D is a fat-soluble vitamin that plays a crucial role in bone health, immune function, and overall well-being. Our bodies can produce vitamin D when our skin is exposed to sunlight, but many people don’t get enough vitamin D from sunlight alone. That’s where supplements come in.

What is 50000 IU Vitamin D3 Weekly?

50000 IU vitamin D3 weekly is a high-dose vitamin D supplement that’s typically prescribed by a healthcare provider. It’s important to note that this dose is much higher than the recommended daily intake of vitamin D, which is 600-800 IU for most adults.

What are the Benefits of 50000 IU Vitamin D3 Weekly?

Some potential benefits of taking 50000 IU vitamin D3 weekly include:

• Improved bone health
• Reduced risk of falls and fractures in older adults
• Reduced risk of certain cancers
• Improved immune function
• Reduced risk of depression and anxiety

However, it’s important to note that more research is needed to fully understand the benefits of high-dose vitamin D supplementation.

What are the Side Effects of 50000 IU Vitamin D3 Weekly?

While vitamin D is generally considered safe, taking high doses can lead to side effects. Some potential side effects of taking 50000 IU vitamin D3 weekly include:

• Nausea and vomiting
• Constipation
• Weakness and fatigue
• Headache
• Loss of appetite
• Increased thirst and urination
• Kidney damage (with long-term use of high doses)

If you experience any of these side effects, it’s important to talk to your healthcare provider.

What are the Risks of 50000 IU Vitamin D3 Weekly?

While vitamin D is generally safe, taking high doses can increase the risk of certain health problems. Some potential risks of taking 50000 IU vitamin D3 weekly include:

• Hypercalcemia (high levels of calcium in the blood)
• Kidney stones
• Heart disease
• Stroke
• Cancer

It’s important to talk to your healthcare provider before taking high-dose vitamin D supplements to determine if it’s right for you.

Book an Appointment with Nao Medical

If you’re interested in taking 50000 IU vitamin D3 weekly or want to learn more about vitamin D supplementation, book an appointment with Nao Medical. Our healthcare providers can help you determine the right dose of vitamin D for your needs and provide personalized recommendations for improving your overall health and well-being.

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Sources

• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356951/
• https://www.mayoclinic.org/drugs-supplements-vitamin-d/art-20363792

Disclaimer: The information presented in this article is intended for general informational purposes only and should not be considered, construed or interpreted as legal or professional advice, guidance or opinion.

Vitamin D 5000 IU: Do You Need the Extra Strength Supplement?

1. What is vitamin D 5000 IU?
2. How much vitamin D do I need?
3. How do I know if I have low vitamin D levels?
4. Can you take too much vitamin D? 

If you have any medical questions or concerns, please talk to your healthcare provider. The articles on Health Guide are underpinned by peer-reviewed research and information drawn from medical societies and governmental agencies. However, they are not a substitute for professional medical advice, diagnosis, or treatment.

You may have seen them at your local drug store: vitamin D 5000 IU tablets, advertised as extra strength or high potency supplements to support healthy bones, muscles, and your immune system.

The truth is, we do need vitamin D to stay healthy, but 5000 IU (units) of vitamin D in a daily tablet is more than most people need. 

The recommended maximum daily limit of vitamin D in healthy people is 4000 IU. That includes intakes from food, beverages, and supplements. Extra strength supplements are intended for people with low vitamin D levels. 

Vitamin D is a nutrient essential for calcium level regulation, strong bones, and healthy immune function.

There are two ways people can get vitamin D: sun exposure and diet (Wimalawansa, 2018). You get most of your vitamin D from sun exposure. The rest comes from the diet. Most people need about 600 to 800 IU (units) of vitamin D per day through their diet (NIH, n.d.). 

Vitamin D 5000 IU is a high-dose supplement that can help treat vitamin D deficiency, which occurs when people don’t get enough vitamin D through the sun or their diet.

This happens quite frequently: people who live in northern climates or those who spend most of their time indoors often don’t get enough exposure to sunlight. What’s more, very few foods naturally contain vitamin D (Naeem, 2010). 

The vitamin D 5000 IU supplements you see in your local drugstore typically contain vitamin D3, a form of vitamin D that is naturally found in fatty fish. Vitamin D2, the other form, is derived from plant sources. You’re more likely to see D3 in supplements, as research has shown that D3 is more effective than D2 in raising vitamin D levels (Tripkovic, 2017). 

Does milk have vitamin D?

Vitamin D

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For those with dietary limitations or inadequate sun exposure, taking vitamin D supplements can help them meet that daily requirement. However, taking too much vitamin D, can have toxic effects.

Remember, the recommended daily limit for most people is 4000 IU (NIH, n.d.). Vitamin D 5000 IU supplements are at the high end of the spectrum. Typical doses of vitamin D supplements come in 400 IU, 800 IU, 1000 IU, and 2000 IU. 

According to research, 42% of adults in the United States don’t get enough vitamin D, and people with darker skin are at an even higher risk; 82.1% of African Americans and 69.2% of Hispanics don’t get enough of the vitamin (Forrest, 2011). The darker your skin, the less vitamin D you make from sunlight exposure.

Most people in the U.S. consume less vitamin D than the recommended 600 to 800 IU per day (NIH, n.d.). Only a few food products naturally contain vitamin D, such as fatty fish and egg yolks. Vitamin D is added to many everyday foods, like milk and cereal, in a public health effort to help make sure everybody is getting enough each day.

Here are some everyday food products and the amount of vitamin D they contain (NIH, n. d.):

• Cod liver oil, 1 tablespoonz: 1,360 IU
• Salmon (sockeye), cooked, 3 ounces: 570 IU
• Trout (rainbow), farmed, cooked, 3 ounces: 645 IU
• Mushrooms, white, raw, sliced, exposed to UV light, ½ cup: 366 IU
• Egg, 1 large, with yolk: 44 IU
• Liver, beef, braised, 3 ounces: 42 IU
• Tuna fish (light), canned in water, drained, 3 ounces: 40 IU
• Sardines (Atlantic), canned in oil, drained, 2 sardines: 46 IU
• Cheese, cheddar, 1 ounce: 12 IU
• Ready-to-eat cereal, fortified with 10% of the DV for vitamin D, 1 serving: 8 IU

Check the nutrition label to see the exact amount of vitamin D a food product contains. The label will tell you how much of your daily vitamin D value is met by each serving. One helpful conversion tip to keep in mind is that 1 mcg equals 40 IU of vitamin D (NIH, n.d.).

For people who don’t typically eat many fish or milk products, vitamin D supplements can help meet the daily recommended requirement.  

The best way to know is to get a vitamin D blood test. But not everyone needs to have their vitamin D levels tested, especially as testing can be expensive, and laboratories may test or report the levels of vitamin D in different ways.

Vitamin D deficiency: symptoms, treatment, and prevention

Vitamin D

Last updated: Oct 25, 2021

7 min read

Experts only recommend testing only for people at high risk for vitamin D deficiency, like those populations at high risk for developing low levels, or those with signs suggestive of a vitamin D problem (Kennel, 2010). Screening tests for vitamin D deficiency are not recommended (U.S. Preventive Service Task Force, 2021). 

The majority of patients with low vitamin D don’t have symptoms. But for severe and prolonged vitamin D deficiencies, some common signs include (Sizar, 2020):

• Muscle weakness
• Fatigue
• Bone pain
• Fractures

The reference ranges for vitamin D blood levels are not well established. According to the NIH’s Office of Dietary Supplements and the Institute of Medicine (IOM), reference ranges are as follows (NIH, n.d.):

Suppose you have low vitamin D levels or vitamin D deficiency. In that case, your healthcare provider may suggest increasing your dietary intake through food products, sun exposure, or supplements, such as high-dose vitamin D 5000 IU pills. 

Work with your doctor to determine if you need a vitamin supplement and how much of it.

If you overdo the supplements, you can get too much vitamin D. If you take supplements with a high amount of the vitamin, like vitamin D 5000 IU, it’s easier to go above the maximum daily intake of 4000 IU. Taking amounts higher than that can increase your risk of vitamin D side effects. Interestingly, getting too much vitamin D is always due to oral intake and not due to excessive sunlight exposure (Sizar, 2020).  

Since vitamin D helps calcium absorption, the toxic effects from high doses often result from high calcium levels in your blood. That can interfere with heart and muscle function (Sadiq, 2020). Common side effects of vitamin D overdose include nausea, vomiting, muscle pain, and frequent urination (Sizar, 2020).

If you’re wondering if you need to take vitamin D 5000 IU supplements, the answer depends on your vitamin D levels. If you suspect that you might have low vitamin D talk to your healthcare provider about whether vitamin D testing is right for you, especially if you fall into one of the high-risk categories. Should you have low vitamin D, your healthcare provider will recommend increasing your dietary intake, either through food or supplements. You shouldn’t take higher-than-recommended doses of vitamin D without first discussing it with your doctor.

2. Forrest, K. Y., & Stuhldreher, W. L. (2011). Prevalence and correlates of vitamin D deficiency in US adults. Nutrition Research, 31(1), 48–54. doi: 10.1016/j.nutres.2010.12.001, https://www.ncbi.nlm.nih.gov/pubmed/21310306
4. Holick M. F., Binkley N. C., Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM., Endocrine Society. (2011). Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. Journal of Clinical Endocrinology and Metabolism, 96(7), 1911-30. doi: 10.1210/jc.2011-0385. Retrieved from https://pubmed.ncbi.nlm.nih.gov/21646368/
6. Kennel, K., Drake, M., & Hurley, D. (2010). Vitamin D Deficiency in Adults: When to Test and How to Treat. Mayo Clinic Proceedings, 85(8), 752-758. doi: 10.4065/mcp.2010.0138. Retrieved from https://pubmed.ncbi.nlm.nih.gov/20675513/
8. Naeem, Z. Vitamin d deficiency- an ignored epidemic. International Journal of Health Science, 4(1):V-VI. Retrieved from https://pubmed.ncbi.nlm.nih.gov/21475519/
10. Office of Dietary Supplements (ODS). (January, 2021). Vitamin D Fact Sheet for Consumers. NIH. Retrieved on February 8, 2021 from https://ods. od.nih.gov/factsheets/VitaminD-Consumer/
12. Office of Dietary Supplements (ODS). (October, 2020). Vitamin D Fact Sheet for Health Professionals. NIH. Retrieved on February 16, 2021 from https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/
14. Sadiq N. M., Naganathan S., Badireddy M. (2021). Hypercalcemia. StatPearls. Retrieved on February 16, 2021 from https://www.ncbi.nlm.nih.gov/books/NBK430714/#_NBK430714
16. Sizar O., Khare S., Goyal A., et al. (2020). Vitamin D Deficiency. StatPearls. Retrieved on February 1, 2021 from https://www.ncbi.nlm.nih.gov/books/NBK532266/
18. Tripkovic, L., Wilson, L. R., Hart, K., Johnsen, S., de Lusignan, S., Smith, C. P., Bucca, G., Penson, S., Chope, G., Elliott, R., Hyppönen, E., Berry, J. L., & Lanham-New, S. A. (2017). Daily supplementation with 15 μg vitamin D2 compared with vitamin D3 to increase wintertime 25-hydroxyvitamin D status in healthy South Asian and white European women: a 12-wk randomized, placebo-controlled food-fortification trial. The American Journal of Clinical Nutrition, 106(2), 481–490. doi: 10.3945/ajcn.116.138693. Retrieved from https://pubmed.ncbi.nlm.nih.gov/28679555/
20. U.S. Preventive Service Task Force. Final Recommendation Statement: Vitamin D Deficiency in Adults: Screening. Retrieved from https://www.uspreventiveservicestaskforce.org/uspstf/document/RecommendationStatementFinal/vitamin-d-deficiency-screening#bootstrap-panel–1
22. Wimalawansa, S. J., Razzaque, M. S., & Al-Daghri, N. M. (2018). Calcium and vitamin D in human health: Hype or real? The Journal of Steroid Biochemistry and Molecular Biology, 180, 4–14. doi: 10.1016/j.jsbmb.2017.12.009. Retrieved from https://pubmed.ncbi.nlm.nih.gov/29258769/

Yael Cooperman is a physician and works as a Senior Manager, Medical Content & Education at Ro.

Composition, before or after meals, dosage, analogues

Publication date: 04/19/2022 POSSIBLE SIDE EFFECTS. A SPECIALIST’S CONSULTATION IS REQUIRED. Rome” composition

The article is dedicated to everyone who wakes up already tired and considers himself a depressed person. Perhaps, in fact, you are able to get enough sleep and enjoy life. In such conditions, it is recommended to take a blood test for vitamin D.

Deficiency of vitamin D, or cholecalciferol, does not appear immediately. Its harbingers can be constant drowsiness and fatigue, even immediately after waking up, excessive sweating during sleep, frequent colds.

Let’s talk about the benefits of Aquadetrim. We will share information about the composition of the product, tell you about the dosage, what is the difference between the composition of drops and tablets. We will also share in detail information about the methods and rules for using Aquadetrim. And also, are there any side effects, is it suitable for pregnant women and newborns, and how does it differ from analogues.

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“Aquadetrim” composition

Tablets : active ingredient – vitamin D3 100 SD / S dry at a dosage of 500 IU per 1 tab, auxiliary components – D,L-α-tocopherol, modified starch, sucrose, crystalline sodium ascorbate, medium chain triglycerides, silicon dioxide, mannitol, sodium benzoate.

Drops : active ingredient – colecalciferol (vit. D3) at a dosage of 500 IU per drop, auxiliary components – macrogol glyceryl ricinoleate, sucrose, sodium hydrogen phosphate dodecahydrate, citric acid monohydrate, anise flavor, benzyl alcohol, purified water.

As can be seen, the content of the active substance in 1 drop and 1 tablet is equivalent.

You may be interested in: Which foods contain the most vitamin D

Aquadetrim how to use

Association of Endocrinologists FGBU “ENDOCRINOLOGICAL SCIENTIFIC CENTER” of the Ministry of Health of the Russian Federation.

Where the recommended drug for treating vitamin D deficiency is cholecalciferol (D3).

Aqueous and oily solutions to be taken according to daily allowances to treat or maintain vitamin D levels.

To correct vitamin D deficiency (less than 20 ng/mL) in adults, 50,000 IU of vitamin D (100 drops) per week within 8 weeks. If the patient is comfortable, he can take the drug every day for 6000-8000 IU (12-15 drops) for 8 weeks.

A dose of 50,000 IU of vitamin D every 2 weeks maintains blood cholecalciferol levels above 30 ng/mL (normal). There are no serious side effects. However, experts do not recommend taking more than 2,000 IU per day unless there are significant risk factors for vitamin D deficiency.

Doctors prescribe Aquadetrim for coronavirus based on test results.

“Aquadetrim” during pregnancy

Pregnant women, according to the instructions for the drug, for preventive purposes, use daily 500 IU (1 drop) / day throughout pregnancy, or 1000 IU (2 drops) / day, starting from 28 weeks pregnancy.

“Aquadetrim” for newborns

In order to prevent term newborns from 4 weeks of life to 2-3 years, with proper care and sufficient exposure to fresh air, the drug is prescribed at a dose of 500 IU (1 drop) / day.

Premature babies from 4 weeks of age, twins and children living in adverse conditions are prescribed 1000-1500 IU (2-3 drops) / day.

In summer, the dose can be reduced to 500 IU (1 drop)/day.

Do you want to understand analogues of drugs in order to skillfully select drugs for your budget? Our manual from expert pharmacists “Analogues of popular drugs” will help you with this! Getting a training manual is easy: subscribe to our social networks and write “analogues” in the messages.

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Aquadetrim side effects

Overdose of colecalciferon is also a manifestation of side effects. Overdose symptoms are: loss of appetite, nausea, vomiting, constipation, anxiety, thirst, diarrhea, intestinal colic.

Vigantol or Aquadetrim, which is better

Both drugs are analogues of each other. They are both listed in the clinical guidelines for the treatment and prevention of vitamin D deficiency. The difference between the drugs lies in their form of release. Both drugs have a liquid form, but Aquadetrim is a water-alcohol solution, and Vigantol is an oil solution. The composition of the oil form contains only the vitamin itself and the oil. Vitamin D is fat soluble, so it is best absorbed in its oil form.

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So, we talked about the drug “Aquadetrim” and would like to summarize.

Aquadetrim is a water-alcohol solution containing colecalciferol at a dosage of 500 IU per 1 drop. It is indicated for use in the treatment and prevention of vitamin D deficiency. The method of application is quite simple, since it is used regardless of food intake 1 time per day. For the prevention of deficiency, it is prescribed to both pregnant women and newborn children.

The main side effect of “Akvadetrim” are overdose symptoms. These include nausea, vomiting, headache, etc.

When choosing between two analogues of “Aquadetrim” or “Vigantol”, it is worth considering that the preparations are different in the composition of the auxiliary components.

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Koledan: instruction, price, analogues | oral drops, solution World Medicine

• Pharmacological properties
• Indications Coledan
• Application Koledan
• Contraindications
• Side effects
• Special instructions
• Interactions
• Overdose
• Storage conditions
• Diagnosis
• Recommended alternatives
• Trade names

pharmacodynamics . Vitamin D ₃ is an active anti-rachitic factor. The most important function of vitamin D is the regulation of calcium and phosphate metabolism, which contributes to proper mineralization and skeletal growth.

Vitamin D ₃ is a natural form of vitamin D that is produced in humans by exposure to sunlight. Compared to Vitamin D ₂ is characterized by 25% higher activity.

It is necessary for the functioning of the parathyroid glands, intestines, kidneys and the skeletal system. Colecalciferol plays a significant role in the absorption of calcium and phosphate from the intestine, in the transport of mineral salts and the process of bone calcification, and regulates the excretion of calcium and phosphate by the kidneys. The presence of calcium ions in the blood in physiological concentrations ensures the maintenance of skeletal muscle tone, myocardial function, promotes the conduction of nervous excitation, and regulates the process of blood coagulation. Vitamin D is also involved in the functioning of the immune system by influencing the production of lymphokines.

Deficiency of vitamin D ₃ in food, weakening of its absorption, calcium deficiency, as well as insufficient exposure to the sun during the period of rapid growth of the child lead to rickets, and in adults – to osteomalacia, in pregnant women – to the appearance of symptoms of tetany and non-formation of the tooth enamel in newborns.

Menopausal women with frequent osteoporosis need to increase their vitamin D dose due to hormonal imbalances ₃ .

Pharmacokinetics

Suction . Water solution of vitamin D ₃ is better absorbed than oil solution. In premature babies, there is insufficient formation and flow of bile into the intestines, which disrupts the absorption of vitamins in the form of oil solutions.

After oral administration, colecalciferol is absorbed in the small intestine.

Distribution . Penetrates through the placental barrier and into breast milk.

Metabolism . It is metabolized in the liver and kidneys, turning into an active metabolite – calcitriol, which combines with a carrier protein and is transported to target organs (intestines, bones, kidneys). The half-life in the blood is several days and may increase in case of kidney disease.

Derivation of . Excreted with urine and feces.

Vitamin D ₃ is involved in the regulation of phosphorus and calcium metabolism in the body 6 hours after taking the drug.

After taking vitamin D ₃ , a significant increase in the level of colecalciferol in the blood plasma is observed already after 48 hours.

• prevention of rickets, including in premature newborns;
• prophylaxis of vitamin D deficiency ₃ in patients with malabsorption and high-risk patients without malabsorption;
• maintenance treatment of osteoporosis;
• treatment of rickets and osteomalacia.
• treatment of hypoparathyroidism.

is intended for oral administration. 1 drop contains 500 IU of vitamin D ₃ . To accurately measure the dose, it is necessary to hold the bottle at an angle of 45 ° during dripping. Adults and older children take the drug in a spoonful of liquid. Infants are given drops in a spoonful of water, milk or cereal. Add the drug to food immediately before eating it.

Adults

Prevention of rickets . The recommended dose of the drug is 1 drop (about 500 IU of vitamin D ₃ ) per day.

Prevention of vitamin D deficiency ₃ in patients with malabsorption and high-risk individuals without malabsorption . The recommended dose of the drug is 1 drop (about 500 IU of vitamin D ₃ ) per day.

Supportive care for osteoporosis . The recommended dose of the drug is 2 drops (about 1000 IU of vitamin D ₃ ) per day.

Treatment of rickets and osteomalacia . The recommended dose of the drug is 2-10 drops per day (1000-5000 IU of vitamin D ₃ per day). Duration of treatment – within 1 year.

Treatment of hypoparathyroidism . The recommended dose of the drug depends on the level of calcium in the blood plasma and is 20–40 drops (about 10,000–20,000 IU of vitamin D ₃ ) per day. If higher doses of cholecalciferol are needed, higher doses of drugs should be used.

Children . The drug is used in children from the 2nd week of life. During the second year of life, there may be a need for further use of the drug, especially in winter. Preventive and therapeutic doses and the duration of the drug are determined individually by the doctor.

General recommended dose for the prevention of rickets in preterm infants is 2 drops (about 1000 IU of vitamin D ₃ ) per day.

The general recommended dose for the treatment of vitamin D deficiency ₃ in children , including neonates, is 2-10 drops (about 1000-5000 IU of vitamin D ₃ ) per day.

The duration of treatment depends on the course and severity of the disease and is determined by the doctor individually. Treatment of rickets and osteomalacia caused by vitamin D deficiency ₃ continues for 1 year.

hypersensitivity to the active substance or other components of the preparation; hypercalcemia and/or hypercalciuria; hypervitaminosis D; sarcoidosis; kidney failure; nephrolithiasis; tuberculosis; pseudohypoparathyroidism (requirement for vitamin D may be lower than during normal vitamin sensitivity). Rare hereditary fructose intolerance, glucose-galactose malabsorption, sucrase-isomaltase deficiency.

Adverse reactions usually do not develop when taken at recommended doses. In the case of individual hypersensitivity to the drug, which is rare, or as a result of the use of too high doses for a long period, hypervitaminosis D may occur.

From the side of metabolism and nutrition: hypercholesterolemia, weight loss, polydipsia.

From the side of the psyche: depression, decreased libido, mental disorders.

From the nervous system: headache, drowsiness.

On the part of the organ of vision: conjunctivitis, photosensitivity.

From the side of the cardiovascular system: arrhythmia, hypertension.

From the digestive tract: loss of appetite, nausea, vomiting, constipation, dry mouth, flatulence, abdominal pain, diarrhoea, dyspepsia, pancreatitis.

From the side of the liver and biliary tract: increased activity of aminotransferases.

From the side of the immune system, skin and subcutaneous tissue: hypersensitivity reactions, including urticaria, rash, itching and anaphylactoid reactions (due to the content of benzyl alcohol in the preparation).

From the musculoskeletal and connective tissues: myalgia, arthralgia, muscle weakness.

From the side of the kidneys and urinary tract: increased levels of calcium in the blood and / or urine, urolithiasis and tissue calcification, uremia, polyuria.

General disorders: increased sweating.

There have also been reports of rhinorrhea, hyperthermia.

Individual provision of vitamin D needs should take into account all possible sources of this vitamin.

Determination of a child’s daily vitamin D requirement and method of administration should be established individually and verified during periodic studies, especially in the first months of life.

Combination therapy with vitamin D or calcium should be used only under medical supervision and with monitoring of plasma and urinary calcium levels. It is not recommended to use colecalciferol simultaneously with high doses of calcium. Too high doses of the drug, used for a long time, or loading doses can cause chronic hypervitaminosis D ₃ .

During the use of the drug, it is recommended to control the level of calcium, phosphate and glucose in the blood plasma and in the urine, and in the case of long-term treatment, control of the level of creatinine in the blood plasma.

The drug should be used with caution in immobilized patients, those with impaired renal function, cardiovascular disease and patients taking both thiazides and cardiac glycosides.

The drug should be used with caution in infants born with a small anterior crown.

Use during pregnancy or lactation . During pregnancy, the drug should not be used in high doses due to the possibility of a teratogenic effect in case of an overdose.

Vitamin D passes into breast milk, so during breastfeeding, the drug should be used only on prescription.

Children. The drug is used in children from the 2nd week of life.

The ability to influence the reaction rate when driving vehicles or operating other mechanisms . There are no messages for today. However, when driving vehicles or other mechanisms, it is recommended to be especially careful, given the possibility of developing adverse reactions from the nervous system.

the following interactions are possible with co-administration of colecalciferol with other medicinal products:

• with aluminum- and magnesium-containing antacids – increased toxic effects of aluminum on bones and the risk of developing hypermagnesemia in patients with renal insufficiency;
• with products containing high doses of calcium or phosphorus – increased risk of hyperphosphatemia;
• with ketoconazole – decreased biosynthesis and catabolism of the 1,25(OH) metabolite ₂ -colecalciferol;
• with metabolites and analogues of vitamin D – increased risk of toxic effects, the simultaneous use of these drugs is possible only as an exception and only under the control of calcium levels in the blood plasma;
• with antiepileptic drugs (phenytoin, phenobarbital), drugs to reduce body weight (orlistat) and lower cholesterol levels, rifampicin – reduced absorption of cholecalciferol;
• with cardiac glycosides – an increase in the severity of the toxic effect of the latter (the risk of developing cardiac arrhythmias increases), the simultaneous use of these drugs should be carried out with caution;
• with thiazides – increased risk of hypercalcemia, the simultaneous use of these drugs should be carried out with caution.

Possible antagonism between cholecalciferol and drugs that are prescribed for hypercalcemia, such as calcitonin, etidronate, pamidronate.

symptoms . An overdose of colecalciferol develops hypercalcemia (occurs after the use of 50,000-100,000 IU of vitamin D ₃ ), hypercalciuria, renal calcifications and bone damage, as well as changes in the cardiovascular system.

Overdose is accompanied by such effects: muscle weakness, loss of appetite, nausea, vomiting, constipation, polydipsia, polyuria, drowsiness, photosensitivity, pancreatitis, rhinorrhea, hyperthermia, decreased libido, conjunctivitis, hypercholesterolemia, increased transaminase activity, hypertension, cardiac arrhythmia and uremia . Common symptoms are muscle and joint pain, headache, weight loss. Renal dysfunction develops with albuminuria, erythrocyturia and polyuria, increased loss of potassium, hypostenuria, nocturia and moderately elevated blood pressure. In severe cases, clouding of the cornea is possible, less often – swelling of the papilla of the optic nerve, inflammation of the iris up to the development of cataracts.

Kidney calculi, calcification of soft tissues such as blood vessels, heart, lungs and skin may form. Rarely develops cholestatic jaundice.

Treatment . In case of overdose, stop using the drug. Depending on the degree of hypercalcemia, a low-calcium or no-calcium diet, fluid intake, forced diuresis induced by the administration of furosemide, as well as the use of corticosteroids and calcitonin are recommended.

In the case of normal kidney function, the calcium level is significantly reduced by the introduction of an infusion solution of sodium chloride (3-6 liters over 24 hours) with the addition of furosemide, in some cases, 15 mg/kg body weight/hour of sodium edetate should also be used, constantly monitoring the level of calcium and ECG. With oligoanuria, on the contrary, hemodialysis is necessary. There is no specific antidote.

at temperatures up to 25 °C in original packaging. After opening the vial, the drug can be used within 6 months.