What are the potential benefits of taking 50000 IU vitamin D weekly. How can high-dose vitamin D supplementation affect your health. What side effects should you be aware of when taking large amounts of vitamin D.

Understanding Vitamin D and Its Importance

Vitamin D is a crucial fat-soluble nutrient that plays a vital role in maintaining overall health. It is often referred to as the “sunshine vitamin” due to our body’s ability to produce it when our skin is exposed to sunlight. However, many individuals struggle to obtain sufficient vitamin D through sunlight exposure alone, leading to the consideration of supplementation.

Why is vitamin D so important? This essential nutrient contributes to:

• Bone health by promoting calcium absorption
• Immune system function
• Muscle strength and function
• Mood regulation
• Cardiovascular health

Given its widespread impact on our bodies, maintaining adequate vitamin D levels is crucial for overall well-being. This has led to increased interest in high-dose vitamin D supplements, such as the 50000 IU weekly dose.

The Basics of 50000 IU Vitamin D3 Weekly Supplementation

A 50000 IU vitamin D3 weekly dose represents a high-potency supplement typically prescribed by healthcare providers. This dosage significantly exceeds the recommended daily intake for most adults, which ranges from 600 to 800 IU. The high dosage is often used as a therapeutic intervention for individuals with severe vitamin D deficiency or those at high risk of deficiency.

Is weekly dosing of vitamin D effective? Research suggests that weekly or monthly high-dose vitamin D supplementation can be as effective as daily dosing in raising and maintaining vitamin D levels in the body. This approach may be preferred by some individuals due to its convenience and potentially improved adherence to the supplementation regimen.

Who Might Benefit from High-Dose Vitamin D?

High-dose vitamin D supplementation may be recommended for:

• Individuals with diagnosed vitamin D deficiency
• Those with limited sun exposure (e.g., living in northern latitudes or working indoors)
• Older adults at risk of osteoporosis
• People with certain medical conditions affecting vitamin D absorption
• Individuals with darker skin tones, who may produce less vitamin D from sunlight

It’s crucial to note that high-dose vitamin D supplementation should only be undertaken under medical supervision and after appropriate testing to determine an individual’s vitamin D status.

Potential Benefits of 50000 IU Vitamin D3 Weekly

While research on high-dose vitamin D supplementation is ongoing, several potential benefits have been associated with maintaining optimal vitamin D levels through supplementation:

1. Enhanced Bone Health

How does vitamin D contribute to bone health? Vitamin D plays a crucial role in calcium absorption and bone mineralization. Adequate vitamin D levels may help:

• Reduce the risk of osteoporosis
• Improve bone density
• Decrease the likelihood of fractures, especially in older adults

2. Improved Immune Function

Can vitamin D boost your immune system? Research suggests that vitamin D plays a role in modulating the immune response. Adequate vitamin D levels may:

• Enhance the body’s ability to fight off infections
• Reduce the risk of autoimmune disorders
• Potentially decrease the severity of certain respiratory infections

3. Potential Mood Regulation

How might vitamin D affect mental health? Some studies have explored the relationship between vitamin D levels and mood disorders. While more research is needed, maintaining adequate vitamin D levels may:

• Potentially reduce the risk of depression
• Help alleviate symptoms of seasonal affective disorder (SAD)
• Contribute to overall emotional well-being

4. Possible Cancer Risk Reduction

Is there a link between vitamin D and cancer prevention? While the relationship between vitamin D and cancer is complex and still being studied, some research suggests that maintaining adequate vitamin D levels may:

• Potentially reduce the risk of certain cancers, including colorectal cancer
• Play a role in regulating cell growth and differentiation

It’s important to note that while these potential benefits are promising, more research is needed to fully understand the impact of high-dose vitamin D supplementation on various health outcomes.

Side Effects and Risks of 50000 IU Vitamin D3 Weekly

While vitamin D is generally considered safe, high-dose supplementation can lead to potential side effects and risks. It’s crucial to be aware of these when considering or using 50000 IU vitamin D3 weekly:

Common Side Effects

What side effects might occur with high-dose vitamin D? Some individuals may experience:

• Nausea and vomiting
• Constipation or diarrhea
• Headache
• Fatigue or weakness
• Loss of appetite
• Increased thirst and urination

These side effects are often mild and may resolve as the body adjusts to the supplementation. However, if they persist or worsen, it’s important to consult a healthcare provider.

Potential Risks of Long-Term High-Dose Supplementation

Can taking too much vitamin D be harmful? Prolonged use of high-dose vitamin D supplements may lead to more serious health risks, including:

• Hypercalcemia (elevated blood calcium levels)
• Kidney stones
• Kidney damage
• Cardiovascular complications

These risks underscore the importance of medical supervision and regular monitoring when using high-dose vitamin D supplements.

Monitoring and Safety Considerations

Given the potential risks associated with high-dose vitamin D supplementation, proper monitoring and safety precautions are essential:

Blood Level Testing

How can you ensure safe vitamin D supplementation? Regular blood tests to monitor vitamin D levels are crucial. These tests help:

• Establish baseline vitamin D status
• Assess the effectiveness of supplementation
• Detect potential vitamin D toxicity

Individualized Dosing

Why is personalized vitamin D supplementation important? Each person’s vitamin D needs can vary based on factors such as:

• Age
• Body weight
• Skin tone
• Geographic location
• Underlying health conditions

Healthcare providers can help determine the most appropriate dosage based on individual circumstances and blood test results.

Interactions with Medications and Health Conditions

High-dose vitamin D supplementation may interact with certain medications and health conditions. It’s crucial to consider these potential interactions:

Medication Interactions

Which medications might interact with vitamin D supplements? Vitamin D may interact with:

• Certain heart medications (e.g., digoxin)
• Some cholesterol-lowering drugs (e.g., cholestyramine)
• Steroid medications
• Weight loss drugs (e.g., orlistat)
• Some antiepileptic medications

It’s essential to inform your healthcare provider about all medications you’re taking before starting high-dose vitamin D supplementation.

Health Conditions

Are there health conditions that may be affected by high-dose vitamin D? Certain conditions require careful consideration when using high-dose vitamin D:

• Hyperparathyroidism
• Kidney disease
• Sarcoidosis
• Certain types of cancer

Individuals with these conditions should consult their healthcare provider before starting high-dose vitamin D supplementation.

Alternatives to High-Dose Vitamin D Supplementation

While 50000 IU vitamin D3 weekly may be necessary for some individuals, there are alternative approaches to maintaining adequate vitamin D levels:

Moderate-Dose Daily Supplementation

Can lower doses of vitamin D be effective? For many people, a moderate daily dose of vitamin D (typically 1000-2000 IU) may be sufficient to maintain adequate levels. This approach may:

• Reduce the risk of side effects
• Provide a more consistent level of vitamin D in the body
• Be easier to adjust based on individual needs

Lifestyle and Dietary Changes

How can you naturally increase your vitamin D levels? Consider these approaches:

• Safe sun exposure (being mindful of skin cancer risks)
• Consuming vitamin D-rich foods (e.g., fatty fish, egg yolks, fortified dairy products)
• Regular outdoor physical activity

These natural methods can help boost vitamin D levels without the need for high-dose supplementation in some cases.

The Importance of Professional Guidance

Given the complexities surrounding high-dose vitamin D supplementation, professional medical guidance is crucial. Healthcare providers can:

• Assess individual vitamin D needs through blood tests
• Recommend appropriate dosages based on personal health status
• Monitor for potential side effects or complications
• Adjust treatment plans as needed
• Consider potential interactions with medications or health conditions

Seeking professional advice ensures that vitamin D supplementation is safe, effective, and tailored to individual needs.

In conclusion, while 50000 IU vitamin D3 weekly supplementation can offer potential benefits for certain individuals, it’s not without risks. Understanding the proper use, potential side effects, and importance of medical supervision is crucial for anyone considering or currently using high-dose vitamin D supplements. By working closely with healthcare providers and staying informed, individuals can make the best decisions for their vitamin D needs and overall health.

Side Effects, Benefits, and Risks

If you’re looking to boost your vitamin D levels, you may have heard about taking 50000 IU vitamin D3 weekly. But is it safe? What are the potential side effects, benefits, and risks? In this blog post, we’ll explore everything you need to know about this high-dose vitamin D supplement.

What is Vitamin D?

Vitamin D is a fat-soluble vitamin that plays a crucial role in bone health, immune function, and overall well-being. Our bodies can produce vitamin D when our skin is exposed to sunlight, but many people don’t get enough vitamin D from sunlight alone. That’s where supplements come in.

What is 50000 IU Vitamin D3 Weekly?

50000 IU vitamin D3 weekly is a high-dose vitamin D supplement that’s typically prescribed by a healthcare provider. It’s important to note that this dose is much higher than the recommended daily intake of vitamin D, which is 600-800 IU for most adults.

What are the Benefits of 50000 IU Vitamin D3 Weekly?

Some potential benefits of taking 50000 IU vitamin D3 weekly include:

• Improved bone health
• Reduced risk of falls and fractures in older adults
• Reduced risk of certain cancers
• Improved immune function
• Reduced risk of depression and anxiety

However, it’s important to note that more research is needed to fully understand the benefits of high-dose vitamin D supplementation.

What are the Side Effects of 50000 IU Vitamin D3 Weekly?

While vitamin D is generally considered safe, taking high doses can lead to side effects. Some potential side effects of taking 50000 IU vitamin D3 weekly include:

• Nausea and vomiting
• Constipation
• Weakness and fatigue
• Headache
• Loss of appetite
• Increased thirst and urination
• Kidney damage (with long-term use of high doses)

If you experience any of these side effects, it’s important to talk to your healthcare provider.

What are the Risks of 50000 IU Vitamin D3 Weekly?

While vitamin D is generally safe, taking high doses can increase the risk of certain health problems. Some potential risks of taking 50000 IU vitamin D3 weekly include:

• Hypercalcemia (high levels of calcium in the blood)
• Kidney stones
• Heart disease
• Stroke
• Cancer

It’s important to talk to your healthcare provider before taking high-dose vitamin D supplements to determine if it’s right for you.

Book an Appointment with Nao Medical

If you’re interested in taking 50000 IU vitamin D3 weekly or want to learn more about vitamin D supplementation, book an appointment with Nao Medical. Our healthcare providers can help you determine the right dose of vitamin D for your needs and provide personalized recommendations for improving your overall health and well-being.

Book Now

Sources

• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356951/
• https://www.mayoclinic.org/drugs-supplements-vitamin-d/art-20363792

Disclaimer: The information presented in this article is intended for general informational purposes only and should not be considered, construed or interpreted as legal or professional advice, guidance or opinion.

Vitamin D 5000 IU: Do You Need the Extra Strength Supplement?

1. What is vitamin D 5000 IU?
2. How much vitamin D do I need?
3. How do I know if I have low vitamin D levels?
4. Can you take too much vitamin D? 

If you have any medical questions or concerns, please talk to your healthcare provider. The articles on Health Guide are underpinned by peer-reviewed research and information drawn from medical societies and governmental agencies. However, they are not a substitute for professional medical advice, diagnosis, or treatment.

You may have seen them at your local drug store: vitamin D 5000 IU tablets, advertised as extra strength or high potency supplements to support healthy bones, muscles, and your immune system.

The truth is, we do need vitamin D to stay healthy, but 5000 IU (units) of vitamin D in a daily tablet is more than most people need. 

The recommended maximum daily limit of vitamin D in healthy people is 4000 IU. That includes intakes from food, beverages, and supplements. Extra strength supplements are intended for people with low vitamin D levels. 

Vitamin D is a nutrient essential for calcium level regulation, strong bones, and healthy immune function.

There are two ways people can get vitamin D: sun exposure and diet (Wimalawansa, 2018). You get most of your vitamin D from sun exposure. The rest comes from the diet. Most people need about 600 to 800 IU (units) of vitamin D per day through their diet (NIH, n.d.). 

Vitamin D 5000 IU is a high-dose supplement that can help treat vitamin D deficiency, which occurs when people don’t get enough vitamin D through the sun or their diet.

This happens quite frequently: people who live in northern climates or those who spend most of their time indoors often don’t get enough exposure to sunlight. What’s more, very few foods naturally contain vitamin D (Naeem, 2010). 

The vitamin D 5000 IU supplements you see in your local drugstore typically contain vitamin D3, a form of vitamin D that is naturally found in fatty fish. Vitamin D2, the other form, is derived from plant sources. You’re more likely to see D3 in supplements, as research has shown that D3 is more effective than D2 in raising vitamin D levels (Tripkovic, 2017). 

Does milk have vitamin D?

Vitamin D

Last updated: Mar 20, 2021

6 min read

For those with dietary limitations or inadequate sun exposure, taking vitamin D supplements can help them meet that daily requirement. However, taking too much vitamin D, can have toxic effects.

Remember, the recommended daily limit for most people is 4000 IU (NIH, n.d.). Vitamin D 5000 IU supplements are at the high end of the spectrum. Typical doses of vitamin D supplements come in 400 IU, 800 IU, 1000 IU, and 2000 IU. 

According to research, 42% of adults in the United States don’t get enough vitamin D, and people with darker skin are at an even higher risk; 82.1% of African Americans and 69.2% of Hispanics don’t get enough of the vitamin (Forrest, 2011). The darker your skin, the less vitamin D you make from sunlight exposure.

Most people in the U.S. consume less vitamin D than the recommended 600 to 800 IU per day (NIH, n.d.). Only a few food products naturally contain vitamin D, such as fatty fish and egg yolks. Vitamin D is added to many everyday foods, like milk and cereal, in a public health effort to help make sure everybody is getting enough each day.

Here are some everyday food products and the amount of vitamin D they contain (NIH, n. d.):

• Cod liver oil, 1 tablespoonz: 1,360 IU
• Salmon (sockeye), cooked, 3 ounces: 570 IU
• Trout (rainbow), farmed, cooked, 3 ounces: 645 IU
• Mushrooms, white, raw, sliced, exposed to UV light, ½ cup: 366 IU
• Egg, 1 large, with yolk: 44 IU
• Liver, beef, braised, 3 ounces: 42 IU
• Tuna fish (light), canned in water, drained, 3 ounces: 40 IU
• Sardines (Atlantic), canned in oil, drained, 2 sardines: 46 IU
• Cheese, cheddar, 1 ounce: 12 IU
• Ready-to-eat cereal, fortified with 10% of the DV for vitamin D, 1 serving: 8 IU

Check the nutrition label to see the exact amount of vitamin D a food product contains. The label will tell you how much of your daily vitamin D value is met by each serving. One helpful conversion tip to keep in mind is that 1 mcg equals 40 IU of vitamin D (NIH, n.d.).

For people who don’t typically eat many fish or milk products, vitamin D supplements can help meet the daily recommended requirement.  

The best way to know is to get a vitamin D blood test. But not everyone needs to have their vitamin D levels tested, especially as testing can be expensive, and laboratories may test or report the levels of vitamin D in different ways.

Vitamin D deficiency: symptoms, treatment, and prevention

Vitamin D

Last updated: Oct 25, 2021

7 min read

Experts only recommend testing only for people at high risk for vitamin D deficiency, like those populations at high risk for developing low levels, or those with signs suggestive of a vitamin D problem (Kennel, 2010). Screening tests for vitamin D deficiency are not recommended (U.S. Preventive Service Task Force, 2021). 

The majority of patients with low vitamin D don’t have symptoms. But for severe and prolonged vitamin D deficiencies, some common signs include (Sizar, 2020):

• Muscle weakness
• Fatigue
• Bone pain
• Fractures

The reference ranges for vitamin D blood levels are not well established. According to the NIH’s Office of Dietary Supplements and the Institute of Medicine (IOM), reference ranges are as follows (NIH, n.d.):

Suppose you have low vitamin D levels or vitamin D deficiency. In that case, your healthcare provider may suggest increasing your dietary intake through food products, sun exposure, or supplements, such as high-dose vitamin D 5000 IU pills. 

Work with your doctor to determine if you need a vitamin supplement and how much of it.

If you overdo the supplements, you can get too much vitamin D. If you take supplements with a high amount of the vitamin, like vitamin D 5000 IU, it’s easier to go above the maximum daily intake of 4000 IU. Taking amounts higher than that can increase your risk of vitamin D side effects. Interestingly, getting too much vitamin D is always due to oral intake and not due to excessive sunlight exposure (Sizar, 2020).  

Since vitamin D helps calcium absorption, the toxic effects from high doses often result from high calcium levels in your blood. That can interfere with heart and muscle function (Sadiq, 2020). Common side effects of vitamin D overdose include nausea, vomiting, muscle pain, and frequent urination (Sizar, 2020).

If you’re wondering if you need to take vitamin D 5000 IU supplements, the answer depends on your vitamin D levels. If you suspect that you might have low vitamin D talk to your healthcare provider about whether vitamin D testing is right for you, especially if you fall into one of the high-risk categories. Should you have low vitamin D, your healthcare provider will recommend increasing your dietary intake, either through food or supplements. You shouldn’t take higher-than-recommended doses of vitamin D without first discussing it with your doctor.

2. Forrest, K. Y., & Stuhldreher, W. L. (2011). Prevalence and correlates of vitamin D deficiency in US adults. Nutrition Research, 31(1), 48–54. doi: 10.1016/j.nutres.2010.12.001, https://www.ncbi.nlm.nih.gov/pubmed/21310306
4. Holick M. F., Binkley N. C., Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM., Endocrine Society. (2011). Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. Journal of Clinical Endocrinology and Metabolism, 96(7), 1911-30. doi: 10.1210/jc.2011-0385. Retrieved from https://pubmed.ncbi.nlm.nih.gov/21646368/
6. Kennel, K., Drake, M., & Hurley, D. (2010). Vitamin D Deficiency in Adults: When to Test and How to Treat. Mayo Clinic Proceedings, 85(8), 752-758. doi: 10.4065/mcp.2010.0138. Retrieved from https://pubmed.ncbi.nlm.nih.gov/20675513/
8. Naeem, Z. Vitamin d deficiency- an ignored epidemic. International Journal of Health Science, 4(1):V-VI. Retrieved from https://pubmed.ncbi.nlm.nih.gov/21475519/
10. Office of Dietary Supplements (ODS). (January, 2021). Vitamin D Fact Sheet for Consumers. NIH. Retrieved on February 8, 2021 from https://ods. od.nih.gov/factsheets/VitaminD-Consumer/
12. Office of Dietary Supplements (ODS). (October, 2020). Vitamin D Fact Sheet for Health Professionals. NIH. Retrieved on February 16, 2021 from https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/
14. Sadiq N. M., Naganathan S., Badireddy M. (2021). Hypercalcemia. StatPearls. Retrieved on February 16, 2021 from https://www.ncbi.nlm.nih.gov/books/NBK430714/#_NBK430714
16. Sizar O., Khare S., Goyal A., et al. (2020). Vitamin D Deficiency. StatPearls. Retrieved on February 1, 2021 from https://www.ncbi.nlm.nih.gov/books/NBK532266/
18. Tripkovic, L., Wilson, L. R., Hart, K., Johnsen, S., de Lusignan, S., Smith, C. P., Bucca, G., Penson, S., Chope, G., Elliott, R., Hyppönen, E., Berry, J. L., & Lanham-New, S. A. (2017). Daily supplementation with 15 μg vitamin D2 compared with vitamin D3 to increase wintertime 25-hydroxyvitamin D status in healthy South Asian and white European women: a 12-wk randomized, placebo-controlled food-fortification trial. The American Journal of Clinical Nutrition, 106(2), 481–490. doi: 10.3945/ajcn.116.138693. Retrieved from https://pubmed.ncbi.nlm.nih.gov/28679555/
20. U.S. Preventive Service Task Force. Final Recommendation Statement: Vitamin D Deficiency in Adults: Screening. Retrieved from https://www.uspreventiveservicestaskforce.org/uspstf/document/RecommendationStatementFinal/vitamin-d-deficiency-screening#bootstrap-panel–1
22. Wimalawansa, S. J., Razzaque, M. S., & Al-Daghri, N. M. (2018). Calcium and vitamin D in human health: Hype or real? The Journal of Steroid Biochemistry and Molecular Biology, 180, 4–14. doi: 10.1016/j.jsbmb.2017.12.009. Retrieved from https://pubmed.ncbi.nlm.nih.gov/29258769/

Yael Cooperman is a physician and works as a Senior Manager, Medical Content & Education at Ro.

Composition, before or after meals, dosage, analogues

Publication date: 04/19/2022 POSSIBLE SIDE EFFECTS. A SPECIALIST’S CONSULTATION IS REQUIRED. Rome” composition

The article is dedicated to everyone who wakes up already tired and considers himself a depressed person. Perhaps, in fact, you are able to get enough sleep and enjoy life. In such conditions, it is recommended to take a blood test for vitamin D.

Deficiency of vitamin D, or cholecalciferol, does not appear immediately. Its harbingers can be constant drowsiness and fatigue, even immediately after waking up, excessive sweating during sleep, frequent colds.

Let’s talk about the benefits of Aquadetrim. We will share information about the composition of the product, tell you about the dosage, what is the difference between the composition of drops and tablets. We will also share in detail information about the methods and rules for using Aquadetrim. And also, are there any side effects, is it suitable for pregnant women and newborns, and how does it differ from analogues.

All products Aquadetrim

27 reviews

“Aquadetrim” composition

Tablets : active ingredient – vitamin D3 100 SD / S dry at a dosage of 500 IU per 1 tab, auxiliary components – D,L-α-tocopherol, modified starch, sucrose, crystalline sodium ascorbate, medium chain triglycerides, silicon dioxide, mannitol, sodium benzoate.

Drops : active ingredient – colecalciferol (vit. D3) at a dosage of 500 IU per drop, auxiliary components – macrogol glyceryl ricinoleate, sucrose, sodium hydrogen phosphate dodecahydrate, citric acid monohydrate, anise flavor, benzyl alcohol, purified water.

As can be seen, the content of the active substance in 1 drop and 1 tablet is equivalent.

You may be interested in: Which foods contain the most vitamin D

Aquadetrim how to use

Association of Endocrinologists FGBU “ENDOCRINOLOGICAL SCIENTIFIC CENTER” of the Ministry of Health of the Russian Federation.

Where the recommended drug for treating vitamin D deficiency is cholecalciferol (D3).

Aqueous and oily solutions to be taken according to daily allowances to treat or maintain vitamin D levels.

To correct vitamin D deficiency (less than 20 ng/mL) in adults, 50,000 IU of vitamin D (100 drops) per week within 8 weeks. If the patient is comfortable, he can take the drug every day for 6000-8000 IU (12-15 drops) for 8 weeks.

A dose of 50,000 IU of vitamin D every 2 weeks maintains blood cholecalciferol levels above 30 ng/mL (normal). There are no serious side effects. However, experts do not recommend taking more than 2,000 IU per day unless there are significant risk factors for vitamin D deficiency.

Doctors prescribe Aquadetrim for coronavirus based on test results.

“Aquadetrim” during pregnancy

Pregnant women, according to the instructions for the drug, for preventive purposes, use daily 500 IU (1 drop) / day throughout pregnancy, or 1000 IU (2 drops) / day, starting from 28 weeks pregnancy.

“Aquadetrim” for newborns

In order to prevent term newborns from 4 weeks of life to 2-3 years, with proper care and sufficient exposure to fresh air, the drug is prescribed at a dose of 500 IU (1 drop) / day.

Premature babies from 4 weeks of age, twins and children living in adverse conditions are prescribed 1000-1500 IU (2-3 drops) / day.

In summer, the dose can be reduced to 500 IU (1 drop)/day.

Do you want to understand analogues of drugs in order to skillfully select drugs for your budget? Our manual from expert pharmacists “Analogues of popular drugs” will help you with this! Getting a training manual is easy: subscribe to our social networks and write “analogues” in the messages.

Megapharmacy in social networks: VKontakte, Telegram, OK, Viber

Aquadetrim side effects

Overdose of colecalciferon is also a manifestation of side effects. Overdose symptoms are: loss of appetite, nausea, vomiting, constipation, anxiety, thirst, diarrhea, intestinal colic.

Vigantol or Aquadetrim, which is better

Both drugs are analogues of each other. They are both listed in the clinical guidelines for the treatment and prevention of vitamin D deficiency. The difference between the drugs lies in their form of release. Both drugs have a liquid form, but Aquadetrim is a water-alcohol solution, and Vigantol is an oil solution. The composition of the oil form contains only the vitamin itself and the oil. Vitamin D is fat soluble, so it is best absorbed in its oil form.

All products Vigantol

20 reviews

So, we talked about the drug “Aquadetrim” and would like to summarize.

Aquadetrim is a water-alcohol solution containing colecalciferol at a dosage of 500 IU per 1 drop. It is indicated for use in the treatment and prevention of vitamin D deficiency. The method of application is quite simple, since it is used regardless of food intake 1 time per day. For the prevention of deficiency, it is prescribed to both pregnant women and newborn children.

The main side effect of “Akvadetrim” are overdose symptoms. These include nausea, vomiting, headache, etc.

When choosing between two analogues of “Aquadetrim” or “Vigantol”, it is worth considering that the preparations are different in the composition of the auxiliary components.

Ask an expert about the topic of the article

Still have questions? Ask them in the comments below and our experts will answer you. You can also share your experience with other Megatips readers.

Share mega tip

Like this article? Tell mom, dad, grandma and aunt Galya from the third entrance

Copy link

Clinical significance of vitamin D interaction with drugs – Lamyra

Given the number of drugs and supplements currently available over the counter, the number of potential interactions between them is enormous. Some commonly prescribed medications can have a negative effect on vitamin D levels.

Among the most likely to affect the concentration of vitamin D are drugs for the treatment of hyperlipidemia, asthma, chronic obstructive pulmonary disease, arthritis, type 2 diabetes, depression – quite common pathologies that require constant use of drugs.

Medications can affect the levels of certain nutrients in the body in different ways. The direct effect may be a violation of the absorption of the nutrient, a decrease in its bioavailability, an increase in excretion in the urine or feces, a decrease in the content of the nutrient in the body. Indirect effects are manifested by a change in eating behavior, diet, appetite, a violation of the perception of taste or smell, the appearance of a feeling of nausea or vomiting; changes in the oral cavity are possible, for example, inflammation of the oral mucosa during chemotherapy. ⁵

Statins

Statin therapy is key in controlling cholesterol levels, reducing the risk of coronary heart disease and associated mortality. Unfortunately, statin-associated muscle symptoms (SAMS, in the English literature – SAMS), occur in 10% of patients and are one of the most common reasons for statin non-compliance and discontinuation. The prevalence of SAMS is associated with low vitamin D levels: patients with myopathic manifestations from statin use are more likely to have low vitamin D concentrations than patients without such myopathic symptoms. ^6-8
Research supports a link between vitamin D deficiency and statin-induced myalgia. ⁹ Further study confirmed that vitamin D supplementation ₃ reduced myopathic symptoms in more than 90% of patients. ⁷

An analysis of a group of people over the age of 60 years with a high incidence of vitamin D deficiency and who received vitamin D supplements showed that the increase in vitamin D concentration was 21.4% weaker among patients who received concomitant statin therapy than among those who did not use this group of drugs. However, this observation did not depend on the dose of vitamin D or on other variables. ¹⁰

And other studies have shown that patients who stopped statin treatment due to myopathy were able to resume statin treatment without muscle symptoms when they combined statin therapy with oral vitamin D supplements. ^11.12 However, in one retrospective cohort study, an association between low vitamin D and statin-induced myalgia was not noted. ¹³

The mechanism explaining the effect of statins on the decrease in vitamin D concentration is not fully understood. It is assumed that it may depend on the type of statin. Low serum vitamin D and statins, acting additively or synergistically, can cause myalgia and myopathy.

Some statins are metabolized in the liver by an enzyme of the cytochrome P450 system called CYP3A4, for which vitamin D is an inducer. Atorvastatin has a moderate inhibitory effect on CYP3A4 activity, ¹⁴
and low baseline serum vitamin D levels may decrease CYP3A4 activity, leading to increased plasma statin levels and statin myotoxicity. ¹⁵ Thus, the development of statin-induced myalgia may be exacerbated by low baseline vitamin D levels in statin users. ¹⁶
A likely explanation for the effectiveness of vitamin D supplementation in statin-induced myalgia is the presence of vitamin D receptors on muscle cells, and the fact that low plasma vitamin D levels can manifest as proximal muscle weakness, hypotonia, prolonged phases of muscle contraction and relaxation and generalized musculoskeletal pain. ^10,17,18
Since vitamin D is an inducer of CYP3A4 and another enzyme of the cytochrome P450 system, CYP2C9, which metabolizes fluvastatin, ¹⁹
Vitamin D supplementation ₃ may reduce myopathic side effects by increasing statin metabolism, thereby reducing statin-induced muscle toxicity. ²⁰ Randomized controlled trials are needed to determine if vitamin D supplementation decreases ₃
risk of statin-associated myalgia.

Corticosteroids

Oral corticosteroids

Corticosteroids are often used in the treatment of asthma, allergies, arthritis, and other inflammation-related conditions. It is well known that both prior and current exposure to corticosteroids increases the risk of bone loss and bone fractures. The use of corticosteroids is the main cause of secondary osteoporosis. ²¹ The National Health and Nutrition Assessment Study (NHANES) showed that oral corticosteroid use was directly associated with 25(OH)D deficiency; this indicates the need for screening and correction of its level in patients constantly taking steroids. ²²

Several randomized controlled trials have been conducted to determine the effectiveness of calcium and vitamin D supplementation ₃ in preventing bone loss, fractures and osteoporosis during corticosteroid treatment.

Meta-analyses show that calcium and vitamin D supplementation ₃
has a pronounced dose-dependent effect on reducing the risk of fractures of the hip, spine, forearm and non-vertebral fractures, regardless of age, gender and manifestations of the underlying disease; ^23–26 this is consistent with guidelines for the prevention and treatment of osteoporosis from corticosteroids. ²⁷

Vitamin D is important in reducing the incidence of skeletal side effects in patients on long-term use of corticosteroids. This is of particular importance in cases where it is impossible to achieve the recommended level of calcium and vitamin D due to its endogenous synthesis in sunlight and a balanced diet, as well as in high risk groups for osteoporosis and bone fractures, such as the elderly, overweight people and postmenopausal women. ^4.28

Side effects of oral corticosteroids are caused by a slowdown in bone formation and a temporary increase in bone resorption. Several mechanisms have been identified in the pathogenesis of this process of bone remodeling. Activation of PPARgamma (peroxisome proliferator-activated gamma receptor) has a direct effect, ^2.29 increased sclerostin expression and increased RANKL/osteoprotegerin ratio; ^30.31
in addition, hypogonadism, changes in the renal and intestinal links of calcium metabolism, as well as a decrease in the synthesis of insulin-like growth factor are also important. ³² Corticosteroids (eg, prednisolone) not only increase vitamin D catabolism, but can also cause significant weight gain. Obesity exacerbates the detrimental effect of corticosteroids on vitamin D status, as vitamin D binds to adipose tissue, reducing its bioavailability. ³³ After initiation of corticosteroids, it is recommended that fracture risk be assessed as soon as possible and, in those at high risk, prompt initiation of bone protection therapy, including calcium and vitamin D, as needed ₃ . ³⁴

Inhaled corticosteroids

The use of inhaled corticosteroids (ICS) is the standard basic therapy for asthma and adjunctive therapy for COPD. Like the NHANES analysis, which showed a significant association between oral steroid use and vitamin D deficiency, ²² a study in 100 children with asthma demonstrated a significant inverse correlation between ICS use and serum vitamin D levels. ³⁵ In adults with asthma, 25(OH)D levels below 30 ng/mL are particularly common among patients with severe and/or uncontrolled asthma despite treatment with inhaled and oral corticosteroids and are significantly correlated with impaired lung function and poor response for therapy. ³⁶ One study evaluated the effectiveness of vitamin D supplementation in vitamin D deficient asthmatic patients for improving asthma control over a period of six months. The vitamin D supplement group experienced a statistically significant clinical improvement in asthma control test scores compared to the control group. The intervention group also showed a significant improvement in quality of life. ³⁷ These results suggest that vitamin D supplementation ₃ in patients with asthma and vitamin D deficiency may reduce asthma severity and improve response to treatment; however, large-scale, well-designed studies are needed.

In addition, an increase in the risk of fractures is dose-dependently associated with the use of ICS, and bone mineral density (BMD) is inversely proportional to the duration of ICS use. In a two-year randomized trial comparing treatment with and without ICS in patients with mild asthma, long-term use of ICS was shown to have a detrimental effect on bone health. Thus, the dose of ICS reduced the density of the thoracic vertebrae, and in the group without ICS, no such relationship was noted. ³⁸
There is some evidence that high doses of ICS may be associated with an increased risk of fracture, although a confounding factor is the frequent concomitant use of oral corticosteroids. ^39-42

Selective serotonin reuptake inhibitors

Numerous studies have found an association of depression with an increased risk of fractures and a decrease in BMD in patients. ^43.44 This decrease in bone density and metabolic changes that promote bone resorption are explained by the complex interaction between the hypothalamic-pituitary-adrenal axis and the inflammation process. ⁴⁵
Depressed patients are more prone to increased cortisol secretion and have elevated levels of inflammatory markers, which in turn can increase cortisol secretion. ⁴⁶ Depression is often accompanied by additional risk factors for low BMD, such as reduced physical activity, vitamin D deficiency, anorexia, and weight loss or reduced calcium intake. ⁴⁷

Selective serotonin reuptake inhibitors (SSRIs) are first-line drugs for the treatment of depression and other psychiatric disorders. ⁴⁸ The use of SSRIs has been associated with a decrease in BMD and a persistently increased risk of fractures. ^45,49,50 Serotonin may act by different mechanisms in different parts of the body, affecting the balance between bone formation and resorption, ⁵¹ but a clear pathophysiological explanation for these phenomena has not yet been found. The relationship between the state of bone tissue and the dose and duration of treatment with SSRIs has been established. ^43.52-54
The effect on bone health appears to be specific to SSRIs and not associated with other types of antidepressants. ⁵⁵ Thus, both depression and SSRIs can each independently increase fracture risk and decrease BMD. The available data are insufficient to determine whether these changes in bone health are due to exposure to SSRIs, the course of the disease, or a combination of both. There is still a need for research on the effectiveness of calcium and vitamin D supplementation ₃
to SSRIs in relation to the effect on BMD and the risk of fractures.

Recommended dose of vitamin D

₃

The vitamin D drug interactions described above highlight the complexity of interactions between specific drugs, pathophysiological changes, and other individual factors such as lifestyle. Therefore, there is probably no “one dose for all”. In patients at risk of deficiency, individual initial measurement of vitamin D levels using a reliable method and subsequent monitoring at regular intervals is necessary. Addition of vitamin D ₃ may play an important role in reducing the risk of adverse events in patients who require long-term treatment for the chronic diseases mentioned above. Despite the many potential benefits of vitamin D supplementation, there is currently no international consensus on recommended dosages. Established intake norms for healthy populations differ from country to country and vary across age groups. ⁵⁶ The needs of patients requiring long-term treatment with drugs that interact with vitamin D are even less well defined. According to the Society of Endocrinologists, at least 1500-2000 IU/day is required even in the general adult population to achieve a constant concentration of vitamin D, which they take as sufficient (25 ng / ml). This is significantly higher than what is usually recommended by national health authorities for healthy adults. ³ A to replenish vitamin D ₃ patients with severe vitamin D deficiency may require higher doses up to 50,000 IU/week with careful monitoring. ¹

In addition to the need for further research into the nature of vitamin D drug interactions and to confirm the additional benefits of vitamin D supplementation ₃ , the next step in integrating vitamin D ₃ into the treatments used should be to raise awareness among healthcare professionals. They should know which populations are at risk for vitamin D deficiency and help determine the correct dosage and avoid side effects.

Finally, guidelines for the management of chronic conditions requiring long-term use of drugs that interfere with vitamin D metabolism, especially statins and corticosteroids, should recommend monitoring of vitamin D levels. for an increased risk of bone fractures and osteoporosis.

Terminals

As discussed, some commonly prescribed drug groups used for the long-term treatment of hyperlipidemia, asthma, COPD, arthritis, diabetes, and depression may have negative effects on bone health or vitamin D levels. ⁴

In hyperlipidemia, the addition of vitamin D ₃ to statin therapy may help increase compliance, reduce the risk of statin-induced myalgia, and reduce myopathic side effects.

Supplementation with calcium and vitamin D ₃ may also reduce the chance of bone loss, fractures, and osteoporosis in patients treated with corticosteroids. Taking extra vitamin D ₃
patients with asthma may positively influence the severity of asthma and improve response to treatment.

In type 2 diabetic patients treated with thiazolidinediones, supplementation with vitamin D ₃ and calcium may reduce the likelihood of fractures in patients at risk for osteoporosis.

Finally, the effectiveness of calcium and vitamin D supplementation in SSRI therapy to reduce the risk of BMD loss and fractures needs to be investigated.

Vitamin D is an essential nutrient and its sufficiency is a public health concern worldwide, as a significant portion of the population is deficient in vitamin D. It has many roles in the body beyond the regulation of the skeletal system, and its most important role is currently recognized in immune function. Deficiency or insufficiency of circulating vitamin D is not only due to low dietary intake or lack of exposure to sunlight. An important but underestimated and usually unrecognized factor is also the long-term or chronic use of drugs prescribed for the treatment of widespread, chronic diseases, especially in the context of an aging population of our planet.

1. Charoenngam, N. & Holick, M. F. Immunologic Effects of Vitamin D on Human Health and Disease. Nutrients 12 (2020).

2. Dusso, A. S., Brown, A. J. & Slatopolsky, E. Vitamin D.

Am J Physiol Renal Physiol 289, F8-28 (2005).

3. Holick, M. F. et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 96, 1911-1930 (2011).

4. Mohn, E. S., Kern, H. J., Saltzman, E., Mitmesser, S. H. & McKay, D. L. Evidence of Drug-Nutrient Interactions with Chronic Use of Commonly Prescribed Medications: An Update. Pharmaceutics 10 (2018).

5. Felípez, L. & Sentongo, T. A. Drug-induced nutrient deficiencies. Pediatr Clin North Am 56, 1211-1224 (2009).

6. Samaras, D. et al. Effects of widely used drugs on micronutrients: a story rarely told. Nutrition 29, 605-610 (2013).

7 Ahmed, W. et al. Low serum 25 (OH) vitamin D levels (<32 ng/mL) are associated with reversible

myositis-myalgia in statin-treated patients. Transl Res

153, 11-16 (2009).

8. Michalska-Kasiczak, M. et al. Analysis of vitamin D levels in patients with and without statin-associated myalgia – a systematic review and meta-analysis of 7 studies with 2420 patients. Int J Cardiol 178, 111-116 (2015).

9. Gupta, A. & Thompson, P. D. The relationship of vitamin D deficiency to statin myopathy. Atherosclerosis 215, 23-29 (2011).

10 Bischoff-Ferrari, H. A. et al. Statin Use and

25-Hydroxyvitamin D Blood Level Response to Vitamin D Treatment of Older Adults. J Am Geriatr Soc 65,

1267-1273 (2017).

11. Glueck, C. J. et al. vitamin D deficiency,

myositis-myalgia, and reversible statin intolerance.

Curr Med Res Opin 27, 1683-1690 (2011).

12. Linde, R., Peng, L., Desai, M. & Feldman, D. The role of vitamin D and SLCO1B1*5 gene polymorphism in statin-associated myalgias. Dermatoendocrinol 2, 77-84 (2010).

13. Kurnik, D. et al. Muscle pain and serum creatine kinase are not associated with low serum 25(OH) vitamin D levels in patients receiving statins. Clin Endocrinol (Oxf) 77, 36-41 (2012).

14. Tirkkonen, T., Heikkilä, P., Vahlberg, T., Huupponen, R. & Laine, K. Epidemiology of CYP3A4-mediated clopidogrel drug-drug interactions and their clinical consequences. Cardiovasc Ther 31, 344-351 (2013).

15. Perez-Castrillón, J. L. et al. Effects of Atorvastatin on vitamin D levels in patients with acute ischemic heart disease. Am J Cardiol 99, 903-905 (2007).

16. Khayznikov, M. et al. Statin Intolerance Because of Myalgia, Myositis, Myopathy, or Myonecrosis Can in Most Cases be Safely Resolved by Vitamin D Supplementation. N Am J Med Sci 7, 86-93 (2015).

17. Thompson, P. D., Clarkson, P. & Karas, R. H. Statin-associated myopathy. Jama 289, 1681-1690 (2003).

18. Harari, M. et al. Increased vitamin D serum levels correlated with clinical improvement of rheumatic diseases after Dead Sea climatotherapy. Isr Med Assoc J 13, 212-215 (2011).

19. Mazidi, M., Rezaie, P., Vatanparast, H. & Kengne, A.