What are the common side effects of stopping Effexor. How long does Effexor withdrawal typically last. What factors influence the severity of Effexor discontinuation syndrome. How can Effexor withdrawal symptoms be effectively managed.

Understanding Effexor and Its Discontinuation Syndrome

Effexor (venlafaxine) is a widely prescribed antidepressant known for its effectiveness in treating various mental health conditions. However, it’s equally notorious for causing uncomfortable withdrawal symptoms when discontinued, a phenomenon referred to as “antidepressant discontinuation syndrome” (ADS). This article delves into the intricacies of Effexor withdrawal, providing valuable insights for those considering or undergoing discontinuation.

What is Effexor and How Does It Work?

Effexor belongs to a class of antidepressants known as Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs). It works by increasing the levels of serotonin and norepinephrine in the brain, neurotransmitters that play crucial roles in mood regulation and emotional well-being. Typically, doctors prescribe an initial dose of 75 mg per day, with the maximum dose ranging from 225 mg to 375 mg daily, depending on the specific formulation and individual patient needs.

Why Does Effexor Cause Withdrawal Symptoms?

When taken regularly, Effexor can lead to physical dependence, a normal physiological adaptation to the medication. This dependence is not addiction but rather the body’s adjustment to the presence of the drug. When Effexor use is abruptly stopped or doses are missed, the body struggles to readjust, resulting in withdrawal symptoms. These symptoms can occur even when the medication is discontinued under medical supervision, highlighting the importance of a carefully managed tapering process.

Recognizing Effexor Withdrawal Symptoms

Effexor withdrawal can manifest through a variety of symptoms, ranging from mild discomfort to more severe effects that can significantly impact daily life. Understanding these symptoms is crucial for anyone considering discontinuation or experiencing unexpected effects after missing doses.

Common Effexor Withdrawal Symptoms

• Vertigo and dizziness
• Nausea and gastrointestinal distress
• Flu-like symptoms
• Anxiety and irritability
• Insomnia or vivid dreams
• Electric shock sensations (brain zaps)
• Lethargy and fatigue
• Loss of coordination

Among these symptoms, “brain zaps” are particularly associated with Effexor discontinuation. These are described as brief electric shock-like sensations that can be accompanied by visual disturbances. While the exact cause remains unclear, Effexor has one of the highest rates of brain zap occurrence among antidepressants.

Can the Severity of Effexor Withdrawal Be Predicted?

Interestingly, research has shown that the presence and severity of Effexor withdrawal symptoms do not necessarily correlate with the dosage. This unpredictability makes it challenging for healthcare providers to anticipate who will experience significant withdrawal effects. Some individuals may develop dependence within just three weeks of regular use, while for others, it may take six weeks or longer.

The Timeline of Effexor Withdrawal

Understanding the typical timeline of Effexor withdrawal can help individuals prepare for and manage their symptoms more effectively. While experiences can vary, there is a general pattern to the onset and duration of withdrawal effects.

When Do Effexor Withdrawal Symptoms Usually Begin?

Withdrawal symptoms typically start to manifest within 8 to 12 hours after the last dose of Effexor. This rapid onset is due to the drug’s relatively short half-life of approximately four hours. Within a day, Effexor is completely eliminated from the body, which can trigger the full spectrum of withdrawal symptoms.

How Long Do Effexor Withdrawal Symptoms Last?

For most individuals, Effexor withdrawal symptoms resolve within one to two weeks. However, it’s important to note that this timeline can vary significantly based on factors such as the duration of treatment, dosage, and individual physiology. Some people may experience lingering effects, particularly brain zaps, for months or even years after discontinuation.

Factors Influencing Effexor Withdrawal

While Effexor withdrawal is a common occurrence, not everyone experiences it to the same degree. Several factors can influence both the likelihood and severity of withdrawal symptoms.

What Percentage of People Experience Effexor Withdrawal?

Studies indicate that approximately 20% of individuals who abruptly stop antidepressant use experience ADS. However, Effexor may have a higher rate, with some research suggesting up to 34% of users may experience withdrawal symptoms. This higher incidence underscores the importance of careful discontinuation planning.

Does the Dosage of Effexor Affect Withdrawal Severity?

Contrary to what one might expect, research has not established a clear correlation between Effexor dosage and the severity of withdrawal symptoms. Higher doses do not necessarily predict more severe ADS, making individual responses to discontinuation highly variable and unpredictable.

Strategies for Managing Effexor Withdrawal

Given the potential discomfort and disruption caused by Effexor withdrawal, it’s crucial to approach discontinuation with a well-thought-out strategy. Several approaches can help minimize symptoms and ensure a smoother transition off the medication.

The Importance of Tapering

The most reliable method for preventing or minimizing Effexor withdrawal symptoms is a gradual tapering of the dose. This process typically involves slowly reducing the medication over a minimum of two weeks, though longer tapering periods may be necessary for some individuals. Tapering allows the body to adjust gradually to decreasing levels of the medication, significantly reducing the risk and severity of withdrawal symptoms.

Can Behavioral Therapies Help with Effexor Withdrawal?

While pharmacological approaches are primary in managing Effexor withdrawal, some studies have shown promising results with behavioral interventions. Cognitive Behavioral Therapy (CBT) and mindfulness-based therapies may help individuals better cope with withdrawal symptoms. These approaches can provide valuable tools for managing anxiety, sleep disturbances, and other psychological effects of discontinuation.

The Role of Medical Supervision in Effexor Discontinuation

Given the complexities and potential risks associated with Effexor withdrawal, medical supervision is crucial throughout the discontinuation process. This oversight ensures safety, provides support, and allows for adjustments to the tapering schedule as needed.

Why is Professional Guidance Important When Stopping Effexor?

Discontinuing Effexor without medical supervision can be dangerous, especially for individuals taking the medication for mental health conditions like depression. Abrupt cessation not only risks severe withdrawal symptoms but can also lead to a recurrence or worsening of the underlying condition. A healthcare provider can monitor for these risks and adjust treatment plans accordingly.

When Might Medical Detox Be Necessary?

While medical detox is not typically required for Effexor withdrawal, certain situations may warrant a more intensive approach. Individuals taking Effexor alongside other substances, or those with complex mental health needs, may benefit from a structured detox program. These programs can provide round-the-clock medical supervision, behavioral support, and a controlled environment to manage withdrawal safely.

Developing a Personalized Effexor Discontinuation Plan

Every individual’s journey with Effexor is unique, and so too should be their approach to discontinuation. A personalized plan, developed in collaboration with a healthcare provider, can significantly improve outcomes and reduce the risk of complications.

What Should a Comprehensive Tapering Plan Include?

An effective Effexor tapering plan should consider several factors:

• Current dosage and duration of treatment
• Individual medical history and risk factors
• Presence of co-occurring mental health conditions
• Previous experiences with medication changes
• Support systems and daily responsibilities

Based on these factors, a healthcare provider can create a tailored schedule for dose reduction, typically involving small decrements over an extended period. This gradual approach allows for close monitoring and adjustment as needed.

How Can Patients Actively Participate in Their Discontinuation Process?

Active patient involvement is crucial for successful Effexor discontinuation. This can include:

1. Keeping a symptom diary to track withdrawal effects
2. Practicing stress-reduction techniques like meditation or deep breathing
3. Maintaining open communication with healthcare providers about concerns or unexpected symptoms
4. Adhering strictly to the prescribed tapering schedule
5. Engaging in regular physical activity to support overall well-being

By taking an active role, patients can contribute valuable insights to their care team and feel more empowered throughout the discontinuation process.

Long-term Considerations After Effexor Discontinuation

While the acute phase of Effexor withdrawal typically resolves within weeks, some individuals may face longer-term challenges. Understanding these potential issues can help in preparing for life after Effexor.

Are There Any Lasting Effects of Effexor Discontinuation?

For most people, Effexor withdrawal symptoms subside completely within a few weeks to months. However, a small subset of individuals may experience protracted withdrawal syndrome, characterized by persistent symptoms such as mood fluctuations, cognitive difficulties, or sensory disturbances. While rare, these cases underscore the importance of ongoing support and monitoring even after the initial discontinuation period.

How Can Individuals Maintain Mental Health After Stopping Effexor?

Maintaining mental health after discontinuing Effexor involves a multifaceted approach:

• Regular follow-ups with mental health professionals
• Continuation of psychotherapy or counseling if beneficial
• Adoption of lifestyle habits that support mental well-being, such as regular exercise, healthy diet, and adequate sleep
• Building and maintaining strong social support networks
• Practicing stress management techniques learned during treatment

These strategies can help individuals navigate the transition off Effexor and maintain long-term mental health stability.

In conclusion, while Effexor withdrawal can present significant challenges, careful planning, medical supervision, and a comprehensive approach to mental health can lead to successful discontinuation. By understanding the potential symptoms, timeline, and management strategies, individuals can approach the process with confidence and preparedness. Remember, the journey off Effexor is unique for each person, and patience, persistence, and professional guidance are key to a positive outcome.

Effexor Withdrawal: Symptoms & Timeline

Last Updated:October 27, 2022

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Effexor (venlafaxine) is notorious for causing uncomfortable withdrawal symptoms, known as “antidepressant discontinuation syndrome.” Effexor is generally prescribed starting at 75 mg per day, but the max dose can range from 225 mg daily to 375 mg daily, depending on the dosage form of the drug. Skipping doses of Effexor or quitting the drug cold turkey, especially at higher doses, can lead to unpleasant withdrawal symptoms. For this reason, it’s important to take Effexor exactly as your doctor prescribes.

Effexor Withdrawal

When your body becomes used to a substance, suddenly stopping it can cause withdrawal symptoms. Someone who abruptly stops taking Effexor may start to experience withdrawal symptoms 8–12 hours after the last dose. Effexor withdrawal symptoms usually resolve within two weeks. 

The most reliable way to prevent or minimize withdrawal symptoms is to gradually taper the Effexor dose over a minimum of two weeks, although a longer taper may be needed. No matter what, it is important to taper Effexor under a doctor’s supervision, especially if you are taking Effexor for a mental health condition like depression. Suddenly stopping Effexor while leaving your mental health untreated may be dangerous.

Effexor Withdrawal Symptoms

Among antidepressants, Effexor is one of the most difficult to quit. Antidepressant discontinuation syndrome (ADS) is characterized by a variety of withdrawal symptoms that occur because of physical dependence. Dependence develops with the regular use of antidepressants. Though it usually develops in six weeks or more, it can develop within just three weeks in some cases.

The presence and severity of Effexor withdrawal symptoms do not seem to be correlated with dose. Currently, it is impossible to reliably predict who will experience symptoms of ADS.

*The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. Consult your doctor if you have any questions or concerns regarding your medications.

Effexor Brain Zaps

Venlafaxine has one of the highest rates of “brain zap” frequency associated with antidepressant discontinuation. Brain zaps are an electric shock sensation that may also include visual disturbances. Doctors are not sure why this phenomenon occurs. Although this symptom resolves quickly in most people, others experience brain zaps for months or years.

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Other Effexor Withdrawal Symptoms

Other common Effexor withdrawal symptoms can be uncomfortable or even debilitating, including:

• Vertigo
• Electric shock sensations in hands or feet
• Nausea
• Lethargy
• Flu-like symptoms
• Loss of coordination
• Anxiety
• Irritability
• Vivid dreams
• Insomnia

Effexor Withdrawal Timeline

The Effexor withdrawal timeline can vary. Symptoms typically begin as early as 12 hours after the last dose and generally resolve within one to two weeks. Because Effexor has a half-life of four hours, it is completely out of the system within a day. Antidepressants with longer half-lives stay in the body for longer amounts of time and may limit the onset and severity of ADS.

Factors Affecting Effexor Withdrawal

ADS typically affects about 20% of people who abruptly stop antidepressant use. However, Effexor may have a somewhat higher rate of ADS frequency — possibly up to 34%. There is currently no reliable way to predict the occurrence of ADS or its severity. Studies have even shown that higher Effexor doses are not predictive of ADS development.

A number of studies have shown that people who taper off of Effexor are significantly less likely to experience ADS, and their symptoms are milder and resolve more quickly compared to people who abruptly stop taking Effexor.

Effexor Withdrawal Treatment

The most reliable way to prevent Effexor withdrawal is to work with your doctor to develop a tapering regime. If you abruptly stop taking Effexor and are experiencing withdrawal symptoms, the only proven way to relieve them is to resume taking Effexor and gradually taper the dose with your doctor. Some studies have shown that cognitive behavioral therapy or mindfulness-based therapies can help people better manage their symptoms.

Medical Detox

Medical detox is not required for Effexor withdrawal, but people with ADS could find success in a rehab center that can help them taper off Effexor safely while providing behavioral therapy and other treatment. 

People who take Effexor along with other substances may benefit from a medical detox to avoid withdrawal complications. This is especially true if you take Effexor for a mental health condition, which can worsen withdrawal symptoms.

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How to Taper Off Effexor

Anyone who is considering quitting Effexor or other antidepressants should consult with a medical professional. Several studies have shown that the best way to prevent ADS and withdrawal symptoms is to gradually discontinue use. 

An Effexor taper schedule may vary from person to person, but a general guideline is to reduce the Effexor dose by 10 mg every two weeks, for a minimum of four weeks. Your doctor can work with you to develop an appropriate tapering schedule that is most effective for your unique situation.

Effexor Withdrawal Remedies

There are no verified remedies for Effexor withdrawal. If you stop Effexor and start to notice withdrawal symptoms, talk to your prescriber immediately. They may be able to restart you on Effexor or another antidepressant, which can resolve your withdrawal.

In addition, it is important to focus on your health, as this may ease withdrawal symptoms. Some tips include:

• Eat a nutritious diet
• Stay well-hydrated 
• Consider regular, light exercise, like yoga
• Consider therapy or counseling, especially if you were taking Effexor for a mental health condition

Alternative Treatments for Effexor Withdrawal

Cross-tapering may be an effective method to prevent or minimize Effexor ADS symptoms. Cross-tapering involves transitioning from high doses of Effexor to another antidepressant, often duloxetine, that has a similar makeup. However, there is a risk of serotonin syndrome if cross-tapering is done incorrectly. A “wash-out” period of approximately five half-lives — about 20 hours for Effexor —  must be done before starting another medication that inhibits serotonin reuptake.

Outpatient Treatment for Effexor Withdrawal

Outpatient rehab programs that offer cognitive behavioral therapies and other forms of psychotherapy may help people experiencing Effexor withdrawal symptoms. Behavioral therapies are also likely to be incredibly beneficial for people who are concerned about experiencing a recurrence of depression or anxiety.

Detoxing From Effexor at Home

Many people who stop using Effexor, either abruptly or with a taper, do so at home. Since quitting abruptly can increase the risk of ADS, it’s essential to follow your doctor’s advice when it comes to quitting Effexor and home and managing side effects. This includes having a friend or loved one available for support, or to help identify mood changes that can come from stopping an antidepressant. 

Finding a Detox Center

If you are concerned about Effexor ADS, it is advised to follow a tapering regimen under the care of medical professionals. Look for a rehab facility that has experience with tapering clients off of antidepressants and provides cognitive behavioral therapy.

Effexor Withdrawal: Symptoms and What You Need To Know

Withdrawal doesn’t only happen if you quit smoking, give up alcohol or recreational drugs.

Some prescription medications, including the antidepressant medication Effexor, can cause a number of withdrawal symptoms if you miss a dose or abruptly stop taking it. 

This isn’t a reason to avoid Effexor (the brand name of the medication venlafaxine).

However, if you use the antidepressant, follow your doctor’s instructions for taking it and, if you wish to change your dose or discontinue the medication, talk to your healthcare provider about how best to do so.

In this article, we’ll discuss what Effexor is and how it works.

Then we’ll dive into the symptoms of withdrawal and the timeline for those effects.

Lastly, we’ll share tips for coping with Effexor withdrawal.

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What Is Effexor?

Effexor is the brand name of the antidepressant venlafaxine.

It belongs to a class of prescription drugs called serotonin-norepinephrine reuptake inhibitors (SNRIs).

Effexor is available as an immediate-release tablet or as an extended-release tablet called Effexor XR.

Effexor uses

Effexor has FDA (Food and Drug Administration) approval for the treatment of major depressive disorder (MDD), generalized anxiety disorder (GAD), panic disorder, and social anxiety disorder (sometimes called social phobia). 

When appropriate, a healthcare provider may prescribe Effexor off-label to treat:

• Attention deficit disorder
• Obsessive-compulsive disorder (OCD)
• Premenstrual dysphoric disorder (PMDD)
• Post-traumatic stress disorder (PTSD
• Fibromyalgia
• Diabetic neuropathy
• Complex pain syndromes
• Hot flashes
• Migraine

How Effexor works

Although researchers are still working to understand the roots of depression and anxiety, many believe that the medical conditions are connected to the bioavailability of neurotransmitters like serotonin, dopamine, and norepinephrine.

In addition to emotional well-being, these brain chemicals affect memory, sleep function, appetite, metabolism, and other functions. 

Effexor blocks how quickly your body reabsorbs serotonin, dopamine, and norepinephrine, leading to higher levels in the brain and improving mood, energy, and sleep.

Symptoms of Effexor Withdrawal

When you take any antidepressant medication, after time, your body becomes used to the resulting increased level of neurotransmitters in the brain.

So if you stop taking Effexor or any other antidepressant too quickly, it can cause a cluster of symptoms called antidepressant discontinuation syndrome.

Generally speaking, antidepressant discontinuation syndrome causes uncomfortable but not serious side effects.

Effexor withdrawal symptoms are similar to those of selective serotonin reuptake inhibitors (SSRIs) but can be notably more intense.

Symptoms include: 

• Irritability
• Restlessness
• Nausea or vomiting
• Dizziness
• Nightmares
• Headache
• Confusion
• Brain zaps (a feeling of electric shocks in the brain)
• Prickly skin sensations
• Flu-like symptoms
• Sweating
• Difficulty concentrating
• Worsening anxiety or symptoms of depression
• Fatigue

Discontinuation symptoms can develop quickly.

If you forget an Effexor dose and begin to experience adverse effects, take your medicine as soon as possible (unless it’s close to the time or your next dose) or seek medical advice.

Do not drive or operate heavy machinery while you feel disoriented or have other severe symptoms.

Timeline for Effexor Withdrawal

Every person is different.

Some experience Effexor discontinuation syndrome more quickly than others: A portion of people report experiencing withdrawal symptoms in as little as 8-12 hours after their last dose.

Physical symptoms can last 3-5 days, and emotional symptoms may continue for up to 1-2 weeks. 

Tips for Coping With Effexor Withdrawal

If you wish to reduce your Effexor dose or discontinue the medication entirely, talk to your doctor or medical professional.

If they give their approval, you can take action to reduce the chances of experiencing adverse effects. 

Closely follow the taper dosage

Your healthcare can help you manage your withdrawal period by tapering your prescription to gently yet quickly decrease your dependence on the drug.

Follow their instructions carefully. Failure to do so can lead to uncomfortable symptoms. 

Try psychotherapy

Studies show that cognitive-behavioral therapy (CBT) or mindfulness-based cognitive therapy (MBCT) may help patients quit antidepressants without increasing the risk of a relapse or new episode of depression.

Your healthcare provider may be able to refer you to therapists who are experienced in helping patients wean off of antidepressants.

Lifestyle changes

Implementing healthy lifestyle changes by getting regular physical activity, eating a healthy diet, sleeping well, and reducing stress may help you manage your mood and reduce your risk of developing symptoms of Effexor withdrawal. 

Over-the-counter medications

A few OTC medications may help remedy some symptoms of antidepressant discontinuation syndrome:

• Pain relievers such as ibuprofen (Advil) and acetaminophen (Tylenol) can help manage body aches.  
• Anti-nausea medication may help reduce GI discomfort.
• Sleep aids may help promote quality rest.

Keep in communication with your healthcare provider

Work with your doctor to create a discontinuation plan.

Then when you begin tapering your medication, contact them at any time if you experience withdrawal symptoms or need health advice or support.

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When to See a Doctor

If you are interested in discontinuing Effexor, talk to your healthcare provider.

They can work with you to ease you off of Effexor and reduce your chances of uncomfortable side effects. 

If you take Effexor and experience any unexpected symptoms—including high fever, seizure, heart palpitations, or loss of consciousness—you may have serotonin syndrome.

Call your doctor or go to the nearest hospital for medical treatment. 

Very rarely, patients develop an allergic reaction to Effexor.

If you experience rash, tingling skin, difficulty breathing or speaking, or swelling in your face, lips, tongue, or throat, you may have a life-threatening condition called anaphylaxis.

Call 911 or go to your nearest emergency room.

How K Health Can Help

Think you might need a prescription for Effexor (Venlafaxine)?

K Health has clinicians standing by 24/7 to evaluate your symptoms and determine if Effexor is right for you.

Get started with our free assessment, which will tell you in minutes if treatment could be a good fit. If yes, we’ll connect you right to a clinician who can prescribe medication and have it shipped right to your door.

Frequently Asked Questions

How long do withdrawals last from Effexor?

While everyone is different, most people with discontinuation symptoms experience discomfort for 1–2 weeks before their symptoms fade away.

Why is Effexor withdrawal so bad?

Effexor affects brain chemistry: It increases the levels of neurotransmitters, which leads to changes in mood, appetite, and sleep. When you stop taking Effexor, your brain chemistry has to adjust. This can cause uncomfortable physical and emotional side effects.

How long does withdrawal from venlafaxine take?

Some patients report feeling the effects of withdrawal from venlafaxine (Effexor) within 8-12 hours after their last dose. Usually those symptoms last a few weeks before tapering off completely.

How do you survive Effexor withdrawal?

Effexor withdrawal is uncomfortable but not medically dangerous. If you are discontinuing your medication and feel ill, talk to your doctor. In addition to tapering your prescription slowly, they can recommend over-the-counter treatment options and lifestyle changes that can help remedy any adverse side effects of withdrawal.

K Health articles are all written and reviewed by MDs, PhDs, NPs, or PharmDs and are for informational purposes only. This information does not constitute and should not be relied on for professional medical advice. Always talk to your doctor about the risks and benefits of any treatment.

K Health has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions,
and medical associations. We avoid using tertiary references.

• Brain 5-HT Deficiency Increases Stress Vulnerability and Impairs Antidepressant Responses Following Psychosocial Stress. (2015).
  https://www.pnas.org/content/112/8/2557

• The Neurobiology of Depression—Revisiting the Serotonin Hypothesis. I. Cellular and Molecular Mechanisms. (2012).
  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405681/

• Relationship of Neurotransmitters to the Symptoms of Major Depressive Disorder. (2008)
  https://pubmed.ncbi.nlm.nih.gov/18494537/

• Venlafaxine. (2021).
  https://www.ncbi.nlm.nih.gov/books/NBK535363/

• Venlafaxine (Effexor). (2020).
  https://www.nami.org/About-Mental-Illness/Treatments/Mental-Health-Medications/Types-of-Medication/Venlafaxine-(Effexor)

• Venlafaxine and Serious Withdrawal Symptoms: Warning to Drivers. (2005).
  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1681629/

• Venlafaxine Withdrawal Syndrome. (2011).
  https://pubmed.ncbi.nlm.nih.gov/21448114/

• Venlafaxine XR Therapy for Major Depression and Anxiety Disorders. The Clinical Implications That Its Advantages Pose. (1999).
  https://pubmed.ncbi.nlm.nih.gov/19667502/

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This document, provided by Lexicomp ^® , contains all the information you need to know about this medicine, including indications, directions for use, side effects, and when your healthcare provider should be contacted.

Trade names: USA

Effexor XR

Brand names: Canada

ACT Venlafaxine XR; APO-Venlafaxine XR; Auro-Venlafaxine XR; Effexor XR; M-Venlafaxine XR; PMS-Venlafaxine XR; PMSC-Venlafaxine XR; RIVA-Venlafaxine XR [DSC]; SANDOZ Venlafaxine XR; TARO-Venlafaxine XR; TEVA-Venlafaxine XR; Venlafaxine XR

Warning

• Drugs like this have increased the likelihood of suicidal thoughts or actions in children and young people. This risk may be higher in people who have tried or had suicidal thoughts in the past. All people taking this drug must be closely monitored. If you develop or worsen disorders such as depression, nervousness, anxiety, grouchiness, panic attacks, and changes in mood or behavior, contact your doctor immediately. Contact your doctor immediately if you have suicidal thoughts or suicide attempts.
• This drug is not approved for use in children. Consult your doctor.

What is this drug used for?

• Used to treat depression.
• Used to treat anxiety.
• Used to treat panic attacks.
• This drug may also be used for other indications. Consult your doctor.

What should I tell my doctor BEFORE taking this drug?

• If you have an allergy to this drug, any of its ingredients, other drugs, foods or substances. Tell your doctor about your allergies and how they have manifested.
• If you have high blood pressure.
• For narrow angle glaucoma.
• If you are taking weight loss medications.
• If you are taking any of the following drugs: linezolid or methylene blue.
• If you have taken medications for depression or Parkinson’s disease in the past 14 days. These include isocarboxazid, phenelzine, tranylcypromine, selegiline, or rasagiline. An episode of very high blood pressure may occur.

This list of drugs and conditions that may interact with this drug is not exhaustive.

Tell your doctor and pharmacist about all medicines you take (prescription and over-the-counter, natural products and vitamins) and any health problems you have. You need to make sure that this drug is safe for your conditions and in combination with other drugs you are already taking. Do not start or stop taking any drug or change the dosage without your doctor’s advice.

What do I need to know or do while taking this drug?

All forms:

• Tell all your health care workers that you are taking this drug. These are doctors, nurses, pharmacists and dentists.
• Avoid driving and other activities that require increased attention until you see how this drug affects you.
• Treatment with this drug should not be abruptly stopped without the consent of the doctor. This can increase the risk of side effects. Sometimes they can be severe and last for a long time. If necessary, this drug should be stopped gradually, as instructed by your doctor. Tell your doctor if you develop new symptoms or if existing ones worsen.
• High blood pressure has happened with this drug. Monitor your blood pressure as directed by your doctor.
• Avoid drinking alcohol while taking this drug.
• Check with your doctor before using marijuana, other forms of cannabis, or prescription or over-the-counter drugs that can slow you down.
• This drug may increase the risk of bleeding. Sometimes bleeding can be life-threatening. Consult your doctor.
• If you have bipolar disorder, manic episodes may occur while taking this drug. Call your doctor if you have signs of a manic episode.
• Some patients may be at increased risk of eye problems when using this drug. Your doctor may order an eye examination to see if you are at increased risk for these eye problems. Call your doctor right away if you have eye pain, vision changes, swelling or redness around the eye.
• This drug may cause low sodium levels in the blood. In very severe cases, it can be deadly. Consult your doctor.
• The use of this drug was accompanied by an increase in cholesterol levels. If you have any questions, please consult your doctor.
• This drug may affect the results of some lab tests. Tell all your health care workers and laboratory staff that you are taking this drug.
• If you are 65 years of age or older, use this drug with caution. You may experience more side effects.
• In some cases, the drug may affect the growth rate in children and adolescents. They may need regular growth rate checks. Consult your doctor.
• Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding. The benefits and risks for you and your child will need to be discussed.
• Taking this drug in the middle or late pregnancy may cause some health problems for the mother or the newborn. Consult your doctor.

Sustained release capsules:

• Particles of this drug can be observed in the feces. This is normal and does not cause concern.

Extended release tablets:

• The shell of the tablet can sometimes be seen in the stool. This is normal and does not cause concern.

What side effects should I report to my doctor immediately?

WARNING. In rare cases, this drug can cause serious and sometimes deadly side effects in some patients. Contact your doctor or seek medical attention right away if you have any of the following signs or symptoms that may be associated with serious side effects:

• Signs of an allergic reaction, such as rash, hives, itching, red and swollen skin with blisters or peeling, possibly accompanied by fever, wheezing or wheezing, tightness in the chest or throat, difficulty breathing, swallowing or speaking, unusual hoarseness, swelling in the mouth, face, lips, tongue or throat.
• Signs of low sodium levels such as headache, trouble concentrating, memory impairment, confused thinking, weakness, seizures, problems with balance.
• signs of bleeding, such as vomiting or coughing up blood; vomiting of the type of coffee grounds; blood in the urine; black, red, or tarry stools; bleeding from the gums; non-cyclic vaginal bleeding; bruises that appear or increase for no reason; bleeding that you cannot stop.
• Signs of high blood pressure, such as a very severe headache, or dizziness, or loss of consciousness, or blurred vision.
• Seizures.
• Pain or pressure in the chest.
• Dyspnea.
• Cough.
• Bone pain.
• Against the background of taking such drugs, violations of sexual function were noted. These included decreased interest in sex, problems achieving orgasm, problems ejaculating, or problems getting or maintaining an erection. If you have any questions, please consult your doctor.
• A severe and sometimes deadly complication called serotonin syndrome can occur. This risk may be increased if certain other drugs are taken at the same time. Call your doctor right away if you experience agitation, balance problems, confusion, hallucinations, high fever, tachycardia or abnormal heart rhythms, flushing, muscle twitching or stiffness, seizures, tremors or tremors, excessive sweating, severe diarrhea, nausea or vomiting , a very severe headache.

What are some other side effects of this drug?

Any medicine can have side effects. However, for many people, side effects are either minor or non-existent. Contact your doctor or seek medical attention if these or any other side effects bother you or do not go away:

• Sleep disorders.
• Nervous tension and agitation.
• Anxiety.
• Weight loss.
• Feeling dizzy, drowsy, tired or weak.
• Shiver.
• Headache.
• Excessive sweating.
• Constipation, diarrhea, abdominal pain, nausea, vomiting, or decreased appetite.
• Gas formation.
• Dry mouth.
• Strange or unusual dreams.
• Yawn.

This list of possible side effects is not exhaustive. If you have any questions about side effects, please contact your doctor. Talk to your doctor about side effects.

You can report side effects to the National Health Board.

You can report side effects to the FDA at 1-800-332-1088. You can also report side effects at https://www.fda.gov/medwatch.

What is the best way to take this drug?

Use this drug as directed by your doctor. Read all the information provided to you. Strictly follow all instructions.

All editions:

• Take this drug with food.
• Take this drug at about the same time of day.
• Keep taking this drug as instructed by your doctor or other health care professional, even if you feel well.

Sustained release capsules:

• Swallow whole. Do not crush, chew, or dissolve the capsules or their contents.
• You can sprinkle the contents of the capsule into applesauce. Do not chew. Swallow immediately and drink cool water.

Extended release tablets:

• Swallow whole. Do not chew, break or crush.
• Take this drug with a full glass of water.

What if I miss a dose of a drug?

• Take the missed dose as soon as you can.
• If it’s time for your next dose, don’t take the missed dose and then go back to your regular dosing schedule.
• Do not take 2 doses or an additional dose at the same time.

How do I store and/or discard this drug?

• Store at room temperature in a dry place. Do not store in the bathroom.
• Keep all medicines in a safe place. Keep all medicines out of the reach of children and pets.
• Dispose of unused or expired drugs. Do not empty into a toilet or sewer unless instructed to do so. If you have any questions about disposing of medicines, ask your pharmacist. Drug recycling programs may be in place in your area.

General information about medicines

• If your health does not improve or even worsens, see your doctor.
• Do not give your medicine to anyone and do not take other people’s medicines.
• Some medicines may come with other patient information leaflets. If you have questions about this drug, talk with your doctor, nurse, pharmacist, or other health care professional.
• A separate instruction for patients is attached to the drug. Please read this information carefully. Reread it each time you refill your supply. If you have any questions about this drug, ask your doctor, pharmacist, or other health care professional.
• If you think you have overdosed, call a poison control center or get medical help right away. Be prepared to tell or show what drug you took, how much, and when it happened.

Consumer Use of Information and Limitation of Liability

This summary information includes a summary of the diagnosis, treatment, and/or drug product. It is not intended to be a comprehensive source of data and should be used as a tool to help the user understand and/or evaluate potential diagnostic and treatment options. It does NOT include all information about conditions, treatments, medications, side effects, or risks that may apply to a particular patient. It should not be considered medical advice or a substitute for medical advice, diagnosis or treatment provided by a physician based on a medical examination and assessment of the patient’s specific and unique circumstances. Patients should consult with their physician for full information about their health, medical issues, and treatment options, including any risks or benefits regarding the use of medications. This information is not a guarantee that a treatment or drug is safe, effective, or approved for a particular patient. UpToDate, Inc. and its subsidiaries disclaim any warranties or liabilities related to this information or its use. The use of this information is subject to the Terms of Use found at https://www.wolterskluwer.com/en/know/clinical-effectiveness-terms.

Last revision date

2022-09-01

Copyright

© UpToDate, Inc. and its affiliates and/or licensors, 2023. All rights reserved.

Date last updated

Monday, December 12, 2022

Venlafaxine: Pediatric Medication | Memorial Sloan Kettering Cancer Center

Pediatric Medicine

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This document provided by Lexicomp ^® contains all the information you need to know about the drug, including indications, directions for use, side effects, and when you should contact your healthcare provider.

Trade names: USA

Effexor XR

Brand names: Canada

ACT Venlafaxine XR; APO-Venlafaxine XR; Auro-Venlafaxine XR; Effexor XR; M-Venlafaxine XR; PMS-Venlafaxine XR; PMSC-Venlafaxine XR; RIVA-Venlafaxine XR [DSC]; SANDOZ Venlafaxine XR; TARO-Venlafaxine XR; TEVA-Venlafaxine XR; Venlafaxine XR

Warning

• Drugs like this have increased the likelihood of suicidal thoughts or actions in children and young people. This risk may be higher in people who have tried or had suicidal thoughts in the past. All people taking this drug must be closely monitored. If you develop or worsen disorders such as depression, nervousness, anxiety, grouchiness, panic attacks, and changes in mood or behavior, contact your doctor immediately. Contact your doctor immediately if you have suicidal thoughts or suicide attempts.
• This drug is not approved for use in children. Consult your doctor.

What is this drug used for?

• Used to treat depression.
• Used to treat anxiety.
• Used to treat panic attacks.
• This drug can be given to children for other indications. Consult your doctor.

What do I need to tell the doctor BEFORE my child takes this drug?

• If your child has an allergy to this drug, any of its ingredients, other drugs, foods, or substances. Tell the doctor about the allergy and how it manifested itself in the child.
• If your child has high blood pressure.
• If your child has angle-closure glaucoma.
• If your child is taking weight loss medications.
• If your child has taken medications for depression or certain other illnesses in the last 14 days. These include isocarboxazid, phenelzine, and tranylcypromine. An episode of very high blood pressure may occur.
• If the child is receiving any of the following drugs: linezolid or methylene blue.

This list of drugs and conditions that may interact with this drug is not exhaustive.

Talk to your doctor or pharmacist about all medicines your child is taking (prescription and over-the-counter, natural, and vitamins) and any health problems. You need to make sure it is safe to take this drug for your child’s illnesses and in combination with other drugs they are already taking. Do not start, stop taking, or change the dosage of any drug your child is taking without the doctor’s approval.

What do I need to know or do while my child is taking this drug?

All forms:

• Tell all health care providers who care for your child that your child is taking this drug. These are your child’s doctors, nurses, pharmacists and dentists.
• Check with your child’s doctor before using marijuana, other forms of cannabis, or prescription or over-the-counter drugs that may slow your child’s progress.
• Have your child avoid tasks or activities that require attention until you see how this drug works for your child. This includes cycling, playing sports, or using items such as scissors, lawn mowers, electric scooters, toy cars, or motorized vehicles.
• Treatment of a child with this drug should not be abruptly stopped without the consent of the doctor. This can increase your child’s risk of side effects. Sometimes they can be severe and last for a long time. If needed, this drug should be stopped gradually for your child as directed by the doctor. Tell the doctor if your child develops new symptoms or if existing ones get worse.
• High blood pressure has happened with this drug. Monitor your child’s blood pressure as directed by your doctor.
• Alcohol can interact with this drug. Make sure your child does not drink alcohol.
• This drug may increase the risk of bleeding. Sometimes bleeding can be life-threatening. Consult your doctor.
• If your child has bipolar disorder, manic episodes may occur while taking this drug. Call your doctor if your child has signs of a manic episode.
• Some patients may be at increased risk of eye problems when using this drug. Your child’s doctor may order an eye examination to see if your child is at increased risk for these eye problems. Call your doctor right away if your child has eye pain, vision changes, swelling, or redness around the eye.
• This drug may cause low sodium levels in the blood. In very severe cases, it can be deadly. Consult your doctor.
• The use of this drug was accompanied by an increase in cholesterol levels. If you have any questions, please consult your doctor.
• This drug may affect the results of some lab tests. Tell all health care workers and laboratory workers who provide your child’s health care that your child is taking this drug.
• In some cases, the drug may affect the growth rate in children and adolescents. They may need regular growth rate checks. Consult your doctor.

If your daughter is pregnant or breastfeeding:

• Consult physician if your daughter is pregnant, pregnant, or breastfeeding. The benefits and risks for your daughter and her baby will need to be discussed.
• Taking this drug in the middle or late pregnancy may cause some health problems for the mother or the newborn. Consult your doctor.

Sustained release capsules:

• You may see particles of this drug in your child’s stool. This is normal and does not cause concern.

Extended release tablets:

• The shell of the tablet can sometimes be seen in the baby’s stool. This is normal and does not cause concern.

What side effects should I report to my child’s doctor right away?

WARNING/CAUTION: Although rare, some people may have very serious and sometimes deadly side effects from this drug. Call your child’s doctor right away or get medical help if your child has any of the following signs or symptoms that could be associated with a very bad side effect:

• Signs of an allergic reaction, such as rash, hives, itching, red and swollen skin with blisters or peeling, possibly accompanied by fever, wheezing or wheezing, tightness in the chest or throat, difficulty breathing, swallowing or speaking, unusual hoarseness, swelling in the mouth, face, lips, tongue or throat.
• Signs of low sodium levels such as headache, trouble concentrating, memory impairment, confused thinking, weakness, seizures, problems with balance.
• signs of bleeding, such as vomiting or coughing up blood; vomiting of the type of coffee grounds; blood in the urine; black, red, or tarry stools; bleeding from the gums; non-cyclic vaginal bleeding; bruises that appear or increase for no reason; bleeding that you cannot stop.
• Signs of high blood pressure, such as a very severe headache, or dizziness, or loss of consciousness, or blurred vision.
• Pain or pressure in the chest.
• Seizures.
• Dyspnea.
• Cough.
• Bone pain.
• A severe and sometimes deadly complication called serotonin syndrome can occur. This risk may be increased if the child is also taking certain other drugs. Call your child’s healthcare provider right away if your child has agitation, balance problems, confusion, hallucinations, high fever, tachycardia or abnormal heart rhythm, flushing, muscle twitching or stiffness, seizures, tremors or tremors, excessive sweating, severe diarrhea, nausea or vomiting, a very severe headache.

If your child is or may be sexually active:

• Against the background of taking such drugs, violations of sexual function were noted. These included decreased interest in sex, problems achieving orgasm, problems ejaculating, or problems getting or maintaining an erection. If you have any questions, please consult your doctor.

What are some other side effects of this drug?

Any drug can cause side effects. However, for many people, side effects are either minor or non-existent. Contact your child’s doctor or seek medical attention if any of these or other side effects bother your child or if they persist:

• Anxiety.
• Weight loss.
• Feeling dizzy, drowsy, tired or weak.
• Shiver.
• Headache.
• Nervous tension and agitation.
• Constipation, diarrhea, nausea, vomiting, or decreased appetite.
• Dry mouth.
• Gas formation.
• Sleep disorders.
• Excessive sweating.
• Strange or unusual dreams.
• Yawn.

This list of possible side effects is not exhaustive. If you have any questions about side effects, ask your child’s doctor. Talk to your child’s doctor about side effects.

You can report side effects to the National Health Board.

What is the best way to give this drug?

Give this drug to your child as directed by your doctor. Read all the information provided to you. Strictly follow all instructions.

All editions:

• Give this drug with food.
• Give this drug at the same time of day.
• Keep giving this drug as directed by your child’s doctor or other health care provider, even if your child is feeling well.

Sustained release capsules:

• The child should swallow the drug whole. Do not let your child crush, chew, or dissolve the capsules or their contents.
• You can sprinkle the contents of the capsules into applesauce. Do not let your child chew the drug. Have your child swallow the medication immediately and drink it with cool water.

Extended release tablets:

• Ask your child to swallow whole. Ask your child not to chew, break, or crush the tablet.
• Give this drug with a full glass of water.

What if my child misses a dose of medication?

• Give the missed dose as soon as possible.
• If it is time for your child to take the next dose, do not take the missed dose and then go back to your child’s normal schedule.
• Do not give a double dose at the same time or additional doses.

How do I store and/or discard this drug?

• Store at room temperature in a dry place. Do not store in the bathroom.
• Keep all medicines in a safe place. Keep all medicines out of the reach of children and pets.
• Dispose of unused or expired drugs. Do not empty into a toilet or sewer unless instructed to do so. If you have any questions about disposing of medicines, ask your pharmacist. Drug recycling programs may be in place in your area.

General information about medicines

• If your child’s symptoms or health problems do not improve, or worsen, contact your child’s doctor.
• Do not share your child’s medicine with others and do not give anyone else’s medicine to your child.
• Some medicines may come with other patient information leaflets. If you have questions about this drug, talk with your child’s doctor, nurse, pharmacist, or other health care professional.
• If you think you have overdosed, call a poison control center or get medical help right away. Be prepared to tell or show what drug you took, how much, and when it happened.

Consumer Use of Information and Limitation of Liability

This summary information includes a summary of the diagnosis, treatment, and/or drug product. It is not intended to be a comprehensive source of data and should be used as a tool to help the user understand and/or evaluate potential diagnostic and treatment options.