What are the potential side effects of taking vitamin D3. How much vitamin D3 is safe to consume. When does vitamin D3 supplementation become risky. What symptoms indicate vitamin D toxicity.

The Importance of Vitamin D and Recommended Intake

Vitamin D is a crucial nutrient that plays a vital role in several bodily processes. It supports calcium absorption, bone health, immune function, and nerve and muscle operation. While many people obtain sufficient vitamin D through sun exposure and diet, some individuals opt for supplements to meet their daily requirements.

The recommended daily intake of vitamin D varies based on individual factors such as age, sex, and overall health. Generally, health professionals consider vitamin D levels adequate when a person has at least 20 nanograms (ng) of the vitamin per milliliter (mL) of blood. However, it’s important to note that levels exceeding 50 ng/mL may lead to adverse side effects.

Daily Vitamin D Requirements

• Varies by individual
• Depends on age, sex, and health status
• Adequate levels: at least 20 ng/mL of blood
• Potential adverse effects: above 50 ng/mL

Can vitamin D supplementation be harmful? While vitamin D is essential for health, excessive intake can lead to toxicity. The Office of Dietary Supplements suggests that toxicity is unlikely with a daily dose of 250 micrograms (mcg) or less. However, even lower doses may have adverse effects if taken long-term.

Understanding Hypercalcemia: A Major Risk of Vitamin D Toxicity

One of the most significant concerns associated with vitamin D toxicity is hypercalcemia, a condition characterized by excess calcium in the blood. Hypercalcemia occurs when blood calcium levels rise above 10.4 mg per deciliter (dL) of blood, or 0.104 mg/mL.

Stages of Hypercalcemia

1. Mild hypercalcemia: 10.5–11.9 mg/dL
2. Moderate hypercalcemia: 12.0–13.9 mg/dL
3. Hypercalcemic crisis: 14.0–16.0 mg/dL

How does vitamin D contribute to hypercalcemia? Vitamin D enhances calcium absorption in the gastrointestinal tract. When vitamin D levels are excessively high, it can lead to an overabundance of calcium in the bloodstream, resulting in various complications and symptoms.

Common Side Effects of Vitamin D Toxicity

Excessive vitamin D intake can lead to a range of side effects, many of which are related to hypercalcemia. These symptoms can vary in severity and may include:

• Loss of appetite and increased thirst
• Digestive issues (diarrhea or constipation)
• Nausea
• Confusion and disorientation
• Joint and muscle pain or weakness
• Persistent headaches
• High blood pressure

Are these side effects immediate or gradual? The onset of symptoms can vary depending on the level of vitamin D toxicity. Some individuals may experience symptoms quickly, while others might develop them over time with prolonged excessive intake.

Kidney Complications: Nephrocalcinosis and Kidney Stones

Vitamin D toxicity can significantly impact kidney health, potentially leading to the development of kidney stones, especially in predisposed individuals. When excess calcium in the bloodstream binds with phosphate, it forms crystals that can deposit in soft body tissues, including the kidneys.

Symptoms of Nephrocalcinosis

• Blood in urine
• Nausea and vomiting
• Fever and chills
• Severe pain in the stomach, sides of the back, or groin area

How serious can kidney complications become? In severe cases, nephrocalcinosis can cause permanent kidney damage and even lead to kidney failure. This underscores the importance of monitoring vitamin D intake and seeking medical attention if symptoms arise.

Cardiovascular Risks Associated with Vitamin D Toxicity

Excessive vitamin D levels have been linked to heart disease and an increased risk of cardiovascular problems. Extreme hypercalcemia can impair the functionality of heart cells and lead to irregularities in heartbeat.

Potential Cardiovascular Complications

• Irregular heartbeat (temporary or continuous)
• Drowsiness
• High blood pressure
• Development of calcium deposits in arteries or heart valves

Can vitamin D toxicity cause long-term heart damage? While acute symptoms may resolve with proper treatment, severe hypercalcemia can potentially lead to lasting cardiovascular issues. Regular monitoring of vitamin D levels is crucial for individuals at risk or those taking high-dose supplements.

Bone Health Implications of Vitamin D Overexposure

Ironically, while vitamin D is essential for bone health, toxicity can have detrimental effects on bone density and overall skeletal well-being. Hypercalcemia resulting from vitamin D toxicity may lead to various bone-related issues.

Bone-related Symptoms of Vitamin D Toxicity

• Aching or painful bones
• Increased susceptibility to fractures
• Development of bone cysts
• Abnormalities in gait

How does vitamin D toxicity affect bone density? Excessive vitamin D can lead to increased calcium absorption, which paradoxically can result in a loss of bone density over time. This emphasizes the importance of maintaining balanced vitamin D levels for optimal bone health.

Dehydration and Urinary Complications

Elevated calcium levels in the blood can impair the kidneys’ ability to concentrate urine, leading to a condition known as polyuria. This results in the production and passage of unusually large quantities of urine, which can quickly lead to dehydration.

Signs of Dehydration

• Dry mouth and tongue
• Increased thirst
• Dark-colored urine
• Headache
• Fatigue

Can dehydration from vitamin D toxicity be dangerous? Severe dehydration can indeed be life-threatening. It may lead to rapid heartbeat and breathing, confusion, fainting, lack of urination, low blood pressure, and unexplained exhaustion. Prompt medical attention is crucial in such cases.

Pancreatitis: A Rare but Serious Complication

Hypercalcemia resulting from vitamin D toxicity can, in some cases, lead to acute pancreatitis, which is inflammation of the pancreas. While less common than other side effects, pancreatitis is a serious condition that requires immediate medical attention.

Symptoms of Acute Pancreatitis

• Upper stomach pain that extends to the back
• Nausea and vomiting
• Rapid heartbeat

How common is pancreatitis in vitamin D toxicity cases? A 2017 review found that 2 out of 19 people with vitamin D toxicity experienced acute pancreatitis as a complication. These individuals had taken an average of 6,000,000 international units (IU) of vitamin D over a period of 1–3 months, highlighting the risks of extremely high doses.

Understanding the potential side effects of vitamin D3 supplementation is crucial for maintaining optimal health. While vitamin D is essential for numerous bodily functions, excessive intake can lead to a range of complications, from mild discomfort to severe health issues. It’s important to consult with a healthcare professional before starting any supplement regimen and to monitor vitamin D levels regularly, especially if taking high doses. By maintaining a balance and staying informed, individuals can harness the benefits of vitamin D while minimizing the risks of toxicity.

Benefits, deficiency, sources and risks

Long-term use of high dose vitamin D supplements may cause adverse side effects, such as dehydration, nausea, vomiting, cardiovascular problems, and confusion.

The Office of Dietary Supplements notes that toxicity is unlikely on a daily dose of 250 microgram (mcg) or less. However, they point out that even these levels or lower may have adverse effects in the long term.

This article details the role of vitamin D in the body and the potential side effects of overexposure.

Vitamin D is a fundamental nutrient that supports several bodily processes, including:

• the absorption and regulation of calcium, magnesium, and phosphate
• the hardening, growth, and remodeling of bones
• immune function
• nerve and muscle function

Many people get enough vitamin D from sun exposure and their diet. Some choose to take supplements.

How much vitamin D should a person take?

A person’s daily vitamin D requirement depends on several individual factors, such as age, sex, and health status.

Doctors consider vitamin D levels adequate if a person has at least 20 nanograms (ng) of the vitamin per milliliter (mL) of blood. If levels rise above 50 ng/mL, a person may experience adverse side effects.

Below are some of the most serious side effects of over-supplementing vitamin D.

Many of the significant side effects of vitamin D toxicity are related to hypercalcemia. Hypercalcemia refers to having excess calcium in the blood.

Researchers often cite this threshold as 10.4 mg of calcium per deciliter (dL) of blood, or as 0.104 mg/mL.

Hypercalcemia has three stages:

There is a strong relationship between vitamin D and calcium. Vitamin D increases calcium absorption in the gastrointestinal tract. Having too much calcium can lead to a wide range of complications and symptoms.

Some of the most serious include:

• a loss of appetite and increased thirst
• diarrhea or constipation
• nausea
• confusion, disorientation, or trouble thinking
• joint and muscle pain or weakness
• continuous headache
• high blood pressure

Excess calcium in the body due to vitamin D toxicity may promote the development of kidney stones in people who are predisposed to the condition.

Excess calcium in the bloodstream binds with phosphate, forming crystals that deposit in soft body tissues. These crystals can cause tissue damage and eventually organ damage, depending on their location, number, and size.

When the crystals get stuck in kidney tissues, nephrocalcinosis (kidney stones) can occur. If this condition is severe, it can cause permanent kidney damage and kidney failure.

Symptoms of nephrocalcinosis include:

• blood in urine
• nausea and vomiting
• fever and chills
• severe pain in the stomach, the sides of the back, or the groin area

Vitamin D levels have links to heart disease and a person’s risk of cardiovascular disease.

Extreme hypercalcemia can reduce the functionality of cells in the heart. People with severe hypercalcemia may also experience irregularities in their heartbeat.

A person with severely high levels of calcium or phosphate in the blood may also develop calcium deposits, or plaques, in the arteries or valves of the heart.

Some signs of heart complications associated with vitamin D toxicity include:

• an irregular heartbeat, which may be temporary or continual
• drowsiness
• high blood pressure

Vitamin D toxicity can cause hypercalcemia and subsequent problems with the bones, including a loss of bone density.

Some symptoms include:

• aching or painful bones
• bones that are prone to fractures or breaks
• bone cysts
• gait abnormalities

Elevated calcium levels in the blood can harm the kidneys’ ability to concentrate urine. This may result in a person producing and passing unusually large quantities of urine, known as polyuria.

When a person passes diluted urine, they lose large quantities of water and electrolytes. For this reason, a person with vitamin D toxicity may be prone to dehydration.

Symptoms of moderate dehydration include:

• a dry mouth and tongue
• increased thirst
• dark-colored urine
• headache
• feeling tired

Severe dehydration can result in life threatening conditions. Other signs and symptoms of this condition include:

• rapid heartbeat and breathing
• confusion
• fainting
• lack of urination
• low blood pressure
• unexplained exhaustion

Hypercalcemia can cause acute pancreatitis, which is the term for inflammation of the pancreas.

A 2017 review found that 2 of 19 people with vitamin D toxicity experienced acute pancreatitis as a complication. Each had taken an average of 6,000,000 international units (IU) of the vitamin over 1–3 months.

Signs of pancreatitis include:

• upper stomach pain that extends to the back
• nausea and vomiting
• a rapid pulse
• swollen or tender abdomen
• fever

A 2018 study found there has been an increase in the incidence of vitamin D toxicity due to more people supplementing vitamin D without a doctor’s supervision. However, symptomatic vitamin D toxicity remains rare.

High vitamin D levels typically result from consuming excessive amounts of high dose dietary supplements. A person cannot get too much vitamin D from the sun.

The 2018 study also found that certain high dose vitamin D formulations (50,000 IU doses) were common in people with elevated vitamin D levels.

The body stores vitamin D in fat tissues, and it can take weeks or months for the effects of vitamin D toxicity to fully wear off.

Dietary vitamin D supplements are useful when it is not possible to otherwise meet the recommended vitamin D requirements. However, vitamin D supplements are not suitable for everyone.

People with the following conditions are at a higher risk of vitamin D toxicity and should consult a healthcare professional before taking any supplements:

• granulomatous disorders, such as sarcoidosis or tuberculosis
• some lymphomas
• idiopathic infantile hypercalcemia
• Crohn’s disease

Vitamin D drug interactions

Vitamin D supplements can interact with some medications.

For example, high dose vitamin D supplements can reduce the efficacy of cholesterol-lowering statins such as atorvastatin. A doctor will assess a person’s health status before prescribing statins. It is essential to follow medical guidance when taking any medications.

Other medications can affect a person’s vitamin D levels.

• Steroids: Steroids such as prednisone can lower vitamin D levels.
• Orlistat: This weight loss medication can decrease vitamin D absorption rates.
• Thiazide diuretics: These medications can raise a person’s blood calcium levels if they take them alongside vitamin D supplements.

While these outcomes are not the direct result of drug interactions, it is important to be aware of them. A person should always consult with a healthcare professional before taking supplements.

Symptoms of vitamin D toxicity include:

• unexplained exhaustion
• dry mouth
• increased thirst and frequency of urination
• nausea and vomiting
• confusion, disorientation, or trouble thinking
• irregular heartbeat

Health risks of too much vitamin D

People with severe or chronic vitamin D toxicity may develop life threatening symptoms, including:

• extreme dehydration
• high blood pressure
• slowed growth
• trouble breathing
• temporary losses of consciousness
• heart failure or heart attack
• kidney stones or kidney failure
• hearing loss
• tinnitus (ringing in the ears)
• pancreatitis (inflammation of the pancreas)
• gastric ulcers
• coma

Vitamin D toxicity can cause a wide range of symptoms, and each individual may respond differently.

A person may have a higher risk of experiencing toxicity if they take high dose supplements over an extended period. Doing this can cause vitamin D to build up in the blood.

The risk of experiencing adverse side effects from vitamin D in the diet or through exposure to the sun is very low.

Vitamin D – Consumer

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What is vitamin D and what does it do?

Vitamin D is a nutrient you need for good health. It helps your body absorb calcium, one of the main building blocks for strong bones. Together with calcium, vitamin D helps protect you from developing osteoporosis, a disease that thins and weakens the bones and makes them more likely to break. Your body needs vitamin D for other functions too. Your muscles need it to move, and your nerves need it to carry messages between your brain and your body. Your immune system needs vitamin D to fight off invading bacteria and viruses.

How much vitamin D do I need?

The amount of vitamin D you need each day depends on your age. Average daily recommended amounts are listed below in micrograms (mcg) and International Units (IU):

What foods provide vitamin D?

Very few foods naturally contain vitamin D. Fortified foods provide most of the vitamin D in the diets of people in the United States. Check the Nutrition Facts label for the amount of vitamin D in a food or beverage.

• Almost all of the U.S. milk supply is fortified with about 3 mcg (120 IU) vitamin D per cup. Many plant-based alternatives such as soy milk, almond milk, and oat milk are similarly fortified. But foods made from milk, like cheese and ice cream, are usually not fortified.
• Vitamin D is added to many breakfast cereals and to some brands of orange juice, yogurt, margarine, and other food products.
• Fatty fish (like trout, salmon, tuna, and mackerel) and fish liver oils are among the best natural sources of vitamin D.
• Beef liver, egg yolks, and cheese have small amounts of vitamin D.
• Mushrooms provide a little vitamin D. Some mushrooms have been exposed to ultraviolet light to increase their vitamin D content.

Can I get vitamin D from the sun?

Your body makes vitamin D when your bare skin is exposed to the sun. Most people get at least some vitamin D this way. However, clouds, smog, old age, and having dark-colored skin reduce the amount of vitamin D your skin makes. Also, your skin does not make vitamin D from sunlight through a window.

Ultraviolet radiation from sunshine can cause skin cancer, so it’s important to limit how much time you spend in the sun. Although sunscreen limits vitamin D production, health experts recommend using sunscreen with a sun protection factor (SPF) of 15 or more when you’re out in the sun for more than a few minutes.

What kinds of vitamin D dietary supplements are available?

Vitamin D is found in multivitamin/multimineral supplements. It is also available in dietary supplements containing only vitamin D or vitamin D combined with a few other nutrients. The two forms of vitamin D in supplements are D2 (ergocalciferol) and D3 (cholecalciferol). Both forms increase vitamin D in your blood, but D3 might raise it higher and for longer than D2. Because vitamin D is fat-soluble, it is best absorbed when taken with a meal or snack that includes some fat.

Am I getting enough vitamin D?

Because you get vitamin D from food, sunshine, and dietary supplements, one way to know if you’re getting enough is a blood test that measures the amount of vitamin D in your blood. In the blood, a form of vitamin D known as 25-hydroxyvitamin D is measured in either nanomoles per liter (nmol/L) or nanograms per milliliter (ng/mL). One nmol/L is equal to 0.4 ng/mL. So, for example, 50 nmol/L is the same as 20 ng/mL.

• Levels of 50 nmol/L (20 ng/mL) or above are adequate for most people for bone and overall health.
• Levels below 30 nmol/L (12 ng/mL) are too low and might weaken your bones and affect your health.
• Levels above 125 nmol/L (50 ng/mL) are too high and might cause health problems.

In the United States, most people have adequate blood levels of vitamin D. However, almost one out of four people have vitamin D blood levels that are too low or inadequate for bone and overall health.

Some people are more likely than others to have trouble getting enough vitamin D:

• Breastfed infants. Breast milk alone does not provide infants with an adequate amount of vitamin D. Breastfed infants should be given a supplement of 10 mcg (400 IU) of vitamin D each day.
• Older adults. As you age, your skin’s ability to make vitamin D when exposed to sunlight declines.
• People who seldom expose their skin to sunshine because they do not go outside or because they keep their body and head covered. Sunscreen also limits the amount of vitamin D your skin produces.
• People with dark skin. The darker your skin, the less vitamin D you make from sunlight exposure.
• People with conditions that limit fat absorption, such as Crohn’s disease, celiac disease, or ulcerative colitis. This is because the vitamin D you consume is absorbed in the gut along with fat, so if your body has trouble absorbing fat, it will also have trouble absorbing vitamin D.
• People with obesity or who have undergone gastric bypass surgery. They may need more vitamin D than other people.

What happens if I don’t get enough vitamin D?

In children, vitamin D deficiency causes rickets, a disease in which the bones become soft, weak, deformed, and painful. In teens and adults, vitamin D deficiency causes osteomalacia, a disorder that causes bone pain and muscle weakness.

What are some effects of vitamin D on health?

Scientists are studying vitamin D to better understand how it affects health. Here are several examples of what this research has shown:

Bone health and osteoporosis

Long-term shortages of vitamin D and calcium cause your bones to become fragile and break more easily. This condition is called osteoporosis. Millions of older women and men have osteoporosis or are at risk of developing this condition. Muscles are also important for healthy bones because they help maintain balance and prevent falls. A shortage of vitamin D may lead to weak, painful muscles.

Getting recommended amounts of vitamin D and calcium from foods (and supplements, if needed) will help maintain healthy bones and prevent osteoporosis. Taking vitamin D and calcium supplements slightly increases bone strength in older adults, but it’s not clear whether they reduce the risk of falling or breaking a bone.

Cancer

Vitamin D does not seem to reduce the risk of developing cancer of the breast, colon, rectum, or lung. It is not clear whether vitamin D affects the risk of prostate cancer or chance of surviving this cancer. Very high blood levels of vitamin D may even increase the risk of pancreatic cancer.

Clinical trials suggest that while vitamin D supplements (with or without calcium) may not affect your risk of getting cancer, they might slightly reduce your risk of dying from this disease. More research is needed to better understand the role that vitamin D plays in cancer prevention and cancer-related death.

Heart disease

Vitamin D is important for a healthy heart and blood vessels and for normal blood pressure. Some studies show that vitamin D supplements might help reduce blood cholesterol levels and high blood pressure—two of the main risk factors for heart disease. Other studies show no benefits. If you are overweight or have obesity, taking vitamin D at doses above 20 mcg (800 IU) per day plus calcium might actually raise your blood pressure. Overall, clinical trials find that vitamin D supplements do not reduce the risk of developing heart disease or dying from it, even if you have low blood levels of the vitamin.

Depression

Vitamin D is needed for your brain to function properly. Some studies have found links between low blood levels of vitamin D and an increased risk of depression. However, clinical trials show that taking vitamin D supplements does not prevent or ease symptoms of depression.

Multiple sclerosis

People who live near the equator have more sun exposure and higher vitamin D levels. They also rarely develop multiple sclerosis (MS), a disease that affects the nerves that carry messages from the brain to the rest of the body. Many studies find a link between low blood vitamin D levels and the risk of developing MS. However, scientists have not actually studied whether vitamin D supplements can prevent MS. In people who have MS, clinical trials show that taking vitamin D supplements does not keep symptoms from getting worse or coming back.

Type 2 diabetes

Vitamin D helps your body regulate blood sugar levels. However, clinical trials in people with and without diabetes show that supplemental vitamin D does not improve blood sugar levels, insulin resistance, or hemoglobin A1c levels (the average level of blood sugar over the past 3 months). Other studies show that vitamin D supplements don’t stop most people with prediabetes from developing diabetes.

Weight loss

Taking vitamin D supplements or eating foods that are rich in vitamin D does not help you lose weight.

Can vitamin D be harmful?

Yes, getting too much vitamin D can be harmful. Very high levels of vitamin D in your blood (greater than 375 nmol/L or 150 ng/mL) can cause nausea, vomiting, muscle weakness, confusion, pain, loss of appetite, dehydration, excessive urination and thirst, and kidney stones. Extremely high levels of vitamin D can cause kidney failure, irregular heartbeat, and even death. High levels of vitamin D are almost always caused by consuming excessive amounts of vitamin D from dietary supplements. You cannot get too much vitamin D from sunshine because your skin limits the amount of vitamin D it makes.

The daily upper limits for vitamin D include intakes from all sources—food, beverages, and supplements—and are listed below in micrograms (mcg) and international units (IU). However, your health care provider might recommend doses above these upper limits for a period of time to treat a vitamin D deficiency.

Does vitamin D interact with medications or other dietary supplements?

Yes, vitamin D supplements may interact with some medicines. Here are several examples:

• Orlistat (Xenical® and alli®) is a weight-loss drug. It can reduce the amount of vitamin D your body absorbs from food and supplements.
• Cholesterol-lowering statins might not work as well if you take high-dose vitamin D supplements. This includes atorvastatin (Lipitor®), lovastatin (Altoprev® and Mevacor®), and simvastatin (FloLipid™ and Zocor®)
• Steroids such as prednisone (Deltasone®, Rayos®, and Sterapred®) can lower your blood levels of vitamin D.
• Thiazide diuretics (such as Hygroton®, Lozol®, and Microzide®) could raise your blood calcium level too high if you take vitamin D supplements.

Tell your doctor, pharmacist, and other health care providers about any dietary supplements and prescription or over-the-counter medicines you take. They can tell you if the dietary supplements might interact with your medicines. They can also explain whether the medicines you take might interfere with how your body absorbs or uses other nutrients.

Vitamin D and healthful eating

People should get most of their nutrients from food and beverages, according to the federal government’s Dietary Guidelines for Americans. Foods contain vitamins, minerals, dietary fiber, and other components that benefit health. In some cases, fortified foods and dietary supplements are useful when it is not possible otherwise to meet needs for one or more nutrients (for example, during specific life stages such as pregnancy). For more information about building a healthy dietary pattern, see the Dietary Guidelines for Americans and the U.S. Department of Agriculture’s MyPlate.

Where can I find out more about vitamin D?

• For more information on vitamin D:
  • Office of Dietary Supplements, Health Professional Fact Sheet on Vitamin D
  • MedlinePlus®, Vitamin D

• For more information on food sources of vitamin D:
  • Office of Dietary Supplements, Health Professional Fact Sheet on Vitamin D
  • U. S. Department of Agriculture (USDA), FoodData Central
  • Nutrient List for vitamin D (listed by food or by vitamin D content), USDA

• For more advice on choosing dietary supplements:
  • Office of Dietary Supplements, Frequently Asked Questions: Which brand(s) of dietary supplements should I purchase?

• For information about building a healthy dietary pattern:
  • Dietary Guidelines for Americans
  • MyPlate

Disclaimer

This fact sheet by the National Institutes of Health (NIH) Office of Dietary Supplements (ODS) provides information that should not take the place of medical advice. We encourage you to talk to your health care providers (doctor, registered dietitian, pharmacist, etc.) about your interest in, questions about, or use of dietary supplements and what may be best for your overall health. Any mention in this publication of a specific product or service, or recommendation from an organization or professional society, does not represent an endorsement by ODS of that product, service, or expert advice.

Updated:
November 8, 2022
History of changes to this fact sheet

Vitamin D3 instructions for use: indications, contraindications, side effects – description Vitamin D3 drops for oral administration 15000 IU/ml: fl. 10 ml, 15 ml or 20 ml (62616)

💊 Composition of the preparation Vitamin D 3 ✅ Use of the preparation Vitamin D 3 Keep for yourself Search for analogues Interaction Description of the active ingredients of the preparation Vitamin D 3 (Vitamin D 3 ) The scientific information provided is general and cannot be used to make decisions. decisions about the use of a particular drug. Update date: 2020.04.24 Marketing authorization holder: MARBIOPHARM JSC (Russia) ATX code: A11CC05 (Cholecalciferol) Active substance: cholecalciferol (colecalciferol) Rec.INN registered by WHO Dosage form Vitamin D 3 Drops for oral administration 15000 IU/ml: vial. 10 ml, 15 ml or 20 ml reg. No.: LP-008253 dated 10. 06.22 – Current Release form, packaging and composition preparation Vitamin D 3 Drops for oral administration in the form of a clear or slightly opalescent colorless or slightly yellowish solution with a characteristic odor. *1 mg cholecalciferol corresponds to 40000 IU of vitamin D activity 3 Excipients : macrogol glyceryl ricinoleate – 75 mg, sucrose – 250 mg, disodium hydrogen phosphate dodecahydrate – 7 mg, citric acid monohydrate – 0.43 mg, benzyl alcohol – 15 mg, purified water – up to 1 ml. 10 ml – orange glass dropper bottles (1) – packs of cardboard. 15 ml – orange glass dropper bottles (1) – packs of cardboard. 20 ml – orange glass dropper bottles (1) – packs of cardboard. 10 ml – brown glass bottles (1) with dropper caps – packs of cardboard. 15 ml – brown glass bottles (1) with droppers – packs of cardboard. 20 ml – brown glass bottles (1) with droppers – cardboard packs. Clinical and pharmacological group: A drug that regulates the metabolism of calcium and phosphorus Pharmacotherapeutic group: Vitamin, regulator of calcium-phosphorus metabolism Pharmacological action Vitamin D 3 , regulator of calcium and phosphorus metabolism. Enhances calcium absorption in the intestine and phosphorus reabsorption in the renal tubules. Promotes the formation of the bone skeleton and teeth in children, maintaining the structure of bones. Necessary for the normal functioning of the parathyroid glands. Participates in the synthesis of lymphokines and ATP. Pharmacokinetics After oral administration, colecalciferol is absorbed from the small intestine. T 1/2 is a few days. Excreted with urine and feces. In case of malfunction T 1/2 may increase. Crosses the placental barrier. It is allocated with breast milk. Indications of the active substances of the drug Vitamin D 3 Prevention and treatment of rickets, spasmophilia, osteomalacia of various origins, metabolic osteopathies (hypoparathyroidism, pseudohypoparathyroidism), hypocalcemic tetany. Open list of ICD-10 codes E20 Hypoparathyroidism E20.1 Pseudohypoparathyroidism E55 Vitamin D deficiency E55.0 Rickets active M83 Osteomalacia in adults M90 Osteopathy in diseases classified elsewhere R29. 0 Tetanya Dosing regimen The method of administration and dosing regimen of a particular drug depends on its form of release and other factors. The optimal dosage regimen is determined by the doctor. Compliance of the dosage form of a particular drug with indications for use and dosing regimen should be strictly observed. Individual, depending on the indication, the dosage form used and the age of the patient. Side effects Symptoms due to hypercalcemia and / or hypercalciuria are most likely with hypersensitivity to colecalciferol and overdose: anorexia, nausea, vomiting, headache, cardiac disturbances, muscle and joint pain, weakness, irritability, depression, weight loss, intense thirst, polyuria, kidney stones, nephrocalcinosis, soft tissue calcification. Contraindications Hypervitaminosis D, hypercalcemia, hypercalciuria, urolithiasis with calcium stones, sarcoidosis, renal failure, hypersensitivity to cholecalciferol. Use in pregnancy and lactation Should not be used in high doses during pregnancy. When used in high doses in a nursing mother, overdose symptoms may develop in the child. Renal dysfunction Contraindicated in renal failure. Use in children When used in children, it is not recommended to exceed a dose of 400,000-600,000 IU per year. For children in conditions of increased insolation, a single and, accordingly, a course dose should be reduced. Use in elderly patients Use with caution in elderly patients. Special instructions May be used in combination with calcium carbonate. Use with caution in elderly patients, as well as in patients with prolonged immobilization. When used in children, it is not recommended to exceed a dose of 400,000-600,000 IU per year. For children in conditions of increased insolation, a single and, accordingly, a course dose should be reduced. When used simultaneously with thiazide diuretics, the level of calcium in the blood and urine should be monitored every 3-6 months. Drug interactions With simultaneous use with anticonvulsants, rifampicin, cholestyramine, the absorption of cholecalciferol decreases. When used simultaneously with cardiac glycosides, it is possible to increase the toxic effect of cardiac glycosides (increased risk of developing cardiac arrhythmias). When used simultaneously with thiazide diuretics, the risk of developing hypercalcemia increases. Keep If you want to place a link to the description of this drug – use this code Vitamin D 3 . Description of the drug in the reference book Vidal.

The effectiveness of vitamin D3 for weight loss: a real find or a myth?

Find out if vitamin D3 can help you lose weight and how it affects your metabolism. Learn how to take vitamin D3 the right way to achieve your desired results and maintain a healthy weight.

In recent years, more and more people are paying attention to vitamin D3 and its connection with the process of losing weight. Many studies show that a lack of this vitamin can lead to weight gain and metabolic problems. But how effective is vitamin D3 for weight loss?

Vitamin D3, or cholecalciferol, is one of the most important vitamins for the body. It plays a key role in the absorption of calcium and phosphorus, as well as in maintaining healthy bones and teeth. However, recent studies have shown that vitamin D3 can also affect metabolism and weight control.

Some studies have linked vitamin D3 deficiency to weight gain. They show that people with low levels of vitamin D3 in the body are more likely to suffer from obesity and metabolic syndrome. Vitamin D3 can help the body use energy from food more efficiently and reduce fat storage.

However, it is worth noting that vitamin D3 is not a “magic” weight loss supplement. Its effect may be negligible and depends on many factors, including general physical activity, diet and overall health of the body. Therefore, before taking vitamin D3 as a weight loss remedy, you should consult your doctor and learn about possible side effects and contraindications.

The effect of vitamin D3 on weight loss: facts and myths

Vitamin D3, also known as cholecalciferol, is one of the key elements for human health. It not only helps to strengthen bones and teeth, but also plays an important role in the metabolic processes of the body. Recently, vitamin D3 has been actively discussed in the context of its effect on the process of losing weight.

Some research indicates that vitamin D3 deficiency may be associated with obesity and difficulty in losing weight. However, it should be noted that there is not enough data to fully confirm this association. More research is needed to better define the role of vitamin D3 in weight loss.

One of the possible mechanisms of the influence of vitamin D3 on the weight loss process is its effect on metabolism. Vitamin D3 may help improve insulin sensitivity, which helps improve metabolism and reduce the risk of obesity. However, more detailed studies are needed to confirm this effect.

In addition, vitamin D3 may affect appetite and satiety. Some studies show that a lack of vitamin D3 can lead to increased appetite and overeating, which in turn can contribute to weight gain. However, these results also require further investigation for confirmation.

In general, vitamin D3 plays an important role in human health and may be associated with weight loss. However, more research is needed to fully understand its effects on metabolic processes and weight regulation. Currently, there is not enough data to draw definitive conclusions about the effect of vitamin D3 on the process of losing weight.

Vitamin D3: main properties and functions

Vitamin D3, also known as cholecalciferol, is one of the most important vitamins for our body. It is a fat-soluble vitamin that we get mainly from sunlight and certain foods.

The main function of vitamin D3 is to regulate the level of calcium and phosphorus in the body. It helps to absorb calcium from food and maintain normal levels in the blood, which is necessary for healthy bones and teeth. Vitamin D3 is also involved in the process of cell division and differentiation, which is important for the normal functioning of the immune system.

Vitamin D3 also plays a role in mood and sleep regulation. It is involved in the synthesis of serotonin, the hormone that is responsible for our mood, and melatonin, the hormone that regulates our sleep-wake cycle.

Vitamin D3 deficiency can lead to various health problems such as weak bones, increased vulnerability to infections, and sleep and mood disturbances. Therefore, it is important to pay attention to your vitamin D3 levels and, if necessary, take additional drugs or consult a doctor for advice.

The role of vitamin D3 in metabolism and energy balance

Vitamin D3, also known as cholecalciferol, plays an important role in the body’s metabolism and energy balance. It is a key factor in maintaining healthy bones and teeth, but its impact on metabolism and body weight cannot be underestimated either.

Optimal levels of vitamin D3 in the body are associated with improved metabolism and more efficient calorie burning. Research suggests that low vitamin D3 levels may be associated with an increased risk of obesity and metabolic syndrome.

Vitamin D3 increases the sensitivity of cells to insulin, which helps to use glucose more efficiently and reduce the risk of type 2 diabetes. It also stimulates thermogenesis – the production of heat in the body, which helps to speed up metabolism and calorie intake.

It is important to note that vitamin D3 is a lipophilic vitamin, meaning it dissolves in fat. Therefore, its absorption and level in the body may depend on the presence of a sufficient amount of fat in the diet. It is recommended to consume foods rich in polyunsaturated fats such as fish, eggs and nuts to ensure normal levels of vitamin D3 in the body and maintain a healthy metabolism and energy balance.

The effect of vitamin D3 on fat burning

Vitamin D3, or cholecalciferol, plays an important role in the regulation of metabolism and may influence the body’s fat burning process. The lack of this vitamin can lead to metabolic disorders and the accumulation of fat reserves.

Research shows that vitamin D3 promotes the activation of the UCP1 protein, which is responsible for thermogenesis, the body’s process of producing heat. An increase in UCP1 activity leads to a faster metabolism and increased fat burning.

In addition, vitamin D3 can increase the sensitivity of cells to insulin, which improves glucose metabolism and prevents the accumulation of body fat. It may also be involved in appetite regulation and food intake control, which also affects the fat burning process.

However, it should be noted that vitamin D3 is not a panacea for weight loss. Its effectiveness may be negligible, especially in the absence of other factors such as proper nutrition and physical activity. Therefore, in order to achieve the desired results, it is necessary to use an integrated approach to losing weight.

Vitamin D3 and appetite: a connection or an accident?

Vitamin D3, also known as cholecalciferol, plays an important role in regulating calcium and phosphorus levels in the body. However, recent research suggests that this vitamin may also affect appetite and metabolism, raising questions about its association with weight loss.

Several studies have shown that low levels of vitamin D3 in the body may be associated with increased appetite and an increased risk of obesity. Vitamin D3 can affect appetite centers in the brain and regulate the production of hormones that control hunger and satiety.

However, it should be noted that there is not enough evidence yet to state that taking vitamin D3 directly leads to a decrease in appetite and an increase in metabolism. Most of the studies were conducted in animals or small groups of people, and these results need further confirmation in a larger sample.

In addition, vitamin D3 is just one of many factors that affect appetite and metabolism. Other factors such as genetics, lifestyle, nutrition and physical activity also play an important role. Therefore, if you want to lose weight, it is important to take into account all these factors and approach the process in a balanced and complex way.

In general, it can be said that the relationship between vitamin D3 and appetite is not yet fully understood and requires further research. However, the level of vitamin D3 in the body is important for overall health, so it is recommended to maintain its norm by regularly eating foods rich in this vitamin, or taking special preparations under the supervision of a physician.

Studies on the effect of vitamin D3 on weight and fat mass

Vitamin D3, also known as cholecalciferol, is an essential nutrient that affects many processes in the human body. A lack of this vitamin may be associated with various diseases, including obesity. In this regard, many studies have been conducted to determine the effect of vitamin D3 on weight and fat mass.

Some studies have shown that vitamin D3 deficiency may be associated with an increased risk of obesity. One study in 218 women found that those with low vitamin D3 levels had a higher body mass index and greater fat mass than those with normal vitamin D3 levels.

Other studies have shown that taking vitamin D3 with a weight loss diet can help you lose weight more effectively. One study in 77 obese women found that those who took vitamin D3 for 12 weeks lost more weight and fat mass than those who did not take the vitamin.

However, not all studies support the beneficial effects of vitamin D3 on weight loss. Some studies have shown no significant difference in weight and fat mass between people who took vitamin D3 and those who did not.

Thus, although some studies indicate a positive effect of vitamin D3 on weight and fat mass, its effectiveness in losing weight is still the subject of further research and debate.

Vitamin D3 dosage for weight loss

Vitamin D3, also known as cholecalciferol, has been linked to the fat burning process and may be helpful for weight loss. However, in order to get the maximum benefit from this vitamin, it is necessary to correctly determine the dosage.

The recommended dose of vitamin D3 for adults is approximately 600-800 IU (international units) per day. However, to achieve the effect of losing weight, some studies recommend increasing the dosage to 1000-4000 IU per day.

It is important to note that taking high doses of vitamin D3 should be under the supervision of a physician, as this may cause side effects. In addition, it is necessary to take into account the individual characteristics of the body and consult a doctor before changing the dosage.

To achieve a slimming effect, it is recommended to take vitamin D3 in combination with regular exercise and a balanced diet. Vitamin D3 may help improve metabolism, increase satiety, and reduce appetite, which can help promote weight loss.

Deriving our reasoning, we can say that the dosage of vitamin D3 to achieve the effect of weight loss should be individual and determined by the doctor. Increasing the dose of vitamin D3 may be beneficial, but caution and health monitoring is required.

Vitamin D3 and physical activity: synergy

Physical activity is an important component of a healthy lifestyle and helps maintain normal weight and overall fitness. However, vitamin D3 plays an important role in maintaining healthy bones and the immune system. Research shows that these two factors can interact and influence each other.

Vitamin D3 promotes the absorption of calcium in the body, which helps to strengthen bones and prevent their destruction. Physical activity, in turn, stimulates the formation of new bone tissue and the strengthening of existing ones. Thus, the synergy of vitamin D3 and physical activity may be particularly beneficial for bone health.

In addition, research suggests that vitamin D3 deficiency may be associated with obesity and an increased risk of metabolic syndrome. Physical activity, in turn, helps burn calories, improves metabolism and promotes weight loss. Therefore, the combined effect of vitamin D3 and physical activity may be beneficial in maintaining normal weight and preventing obesity.

However, it should be noted that research in this area is still ongoing and it is not completely clear how vitamin D3 and physical activity interact with each other. Therefore, before deciding to take vitamin D3 for weight loss, it is recommended to consult a doctor and conduct a comprehensive examination of the body.

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Q&A:

Does vitamin D3 affect the weight loss process?

Yes, vitamin D3 can have an effect on weight loss. Studies show that a lack of vitamin D3 can lead to weight gain and obesity, while a sufficient amount in the body improves metabolism and weight loss. However, it must be remembered that vitamin D3 is not a panacea for weight loss and its effectiveness can be individual.

How does vitamin D3 affect metabolism?

Vitamin D3 plays an important role in the regulation of metabolism. It helps to absorb calcium and phosphorus, which helps to strengthen bones. In addition, vitamin D3 is involved in the regulation of insulin production and the control of blood glucose levels. It can help improve metabolism and promote weight loss.

What dosage of vitamin D3 should I use for weight loss?

The dosage of vitamin D3 for weight loss may depend on the individual. It is generally recommended to take 1,000 to 5,000 IU (international units) of vitamin D3 per day. However, before starting to take vitamin D3 in large doses, it is recommended to consult a doctor to avoid possible side effects.

Which foods contain vitamin D3?

Vitamin D3 can be obtained not only from food, but also from exposure to sunlight. However, the main dietary sources of vitamin D3 include fatty fish (salmon, sardines, cod), dairy products, eggs, and mushrooms. If the diet lacks these foods, then you can consider taking vitamin complexes with vitamin D3.

Are there side effects from taking high doses of vitamin D3?

High doses of vitamin D3 may cause some side effects such as nausea, vomiting, fatigue, headache and calcium sensitivity. Therefore, before starting to take vitamin D3 in large doses, it is recommended to consult a doctor in order to avoid side effects and determine the correct dosage.

Reviews

Dmitry Petrov

The article is very interesting and relevant. I have long noticed that my excess adipose tissue is concentrated mainly in the abdomen, and I am constantly looking for ways to get rid of it. When I learned about the possible connection between vitamin D3 and weight loss, I immediately became interested. It turns out that this substance can help speed up metabolism and fat burning. But of course, I’m not going to rely on vitamin D3 alone to reach my goal. It is important to eat a healthy diet and exercise regularly. In any case, I look forward to further research and hope that vitamin D3 can actually be a real boon in the fight against excess weight.

sweetheart

The article is very interesting and relevant for me, since I have been striving to lose weight for a long time. Vitamin D3 is familiar to me, but I never thought that it could help in the fight against excess weight. Therefore, I enjoyed reading all the author’s arguments and scientific research. It turns out that vitamin D3 improves metabolism, which can help in burning fat. I would like to try adding it to my diet and see how it affects my weight loss process. Of course, I understand that vitamin D3 is not a panacea and will not replace proper nutrition and physical activity, but if it can further support my efforts, then why not try it? In any case, thanks to the author for the interesting information!

ladykiller

The article is very interesting! I was always looking for ways to lose weight, and vitamin D3 seemed promising to me. But after reading the article, I realized that its effectiveness for weight loss is not as clear as many say. Vitamin D3 is indeed important for bone health and the immune system, but its link to weight loss is less clear. Although some research suggests that a lack of vitamin D3 may be associated with obesity, this does not mean that taking it will automatically lead to weight loss. As always, the most important thing is proper nutrition and physical activity. So I will still focus on a healthy lifestyle, and I will take vitamin D3 to maintain my health. Thank you for the article!

Alexander Ivanov

The article is very interesting and relevant. I have always been skeptical about various diets and weight loss supplements, but vitamin D3 piqued my interest. Studies show that a lack of this vitamin can lead to overweight and obesity. However, I do not believe that vitamin D3 is a miracle drug for weight loss. To achieve effective results, it is necessary to combine the intake of vitamin D3 with proper nutrition and exercise. I believe that vitamin D3 can be a useful addition to a comprehensive weight loss program, but is not the only solution. I am going to consult with my doctor to find out what dosage of vitamin D3 I should take and what effect to expect. Overall, I believe that vitamin D3 can be a useful tool for weight loss, but should not be viewed as a magical solution to overweight problems.

Maximus007

I doubted the effectiveness of vitamin D3 for weight loss for a long time, but I decided to try it and was surprised at the result. Indeed, this vitamin helps speed up the metabolism, which promotes fat burning. I noticed that after taking D3, my body became leaner and my tummy became flatter. Of course, vitamin D3 itself is not a magic weight loss remedy, but it does help speed up the process and achieve the desired results. I recommend trying it to anyone who wants to lose weight. However, do not forget that before starting any supplements, it is better to consult a doctor.