Side effects lipoic acid: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews
How to Protect Your Eyes When You Have Diabetes
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Mayo Clinic: “Top 5 lifestyle changes to improve your cholesterol,” “Diabetes management: How lifestyle, daily routine affect blood sugar.”
American Journal of Nursing: “Omega-3 Fatty Acid Intake Lowers Risk of Diabetic Retinopathy.”
Cleveland Clinic: “If You Have Diabetes, Can Omega-3s Protect Your Eyes?”
Harvard Health Publishing: “Mindfulness meditation may ease anxiety, mental stress,” “Glycemic index and glycemic load for 100+ foods,” “11 foods that lower cholesterol. “
American Optometric Association: “Lutein & Zeaxanthin.”
All About Vision: “How Smoking Harms Your Vision.”
Alpha-Lipoic Acid (Alpha Lipoic) – Side Effects, Interactions, Uses, Dosage, Warnings
Alpha-lipoic acid is an antioxidant also known as Acetate Replacing Factor, ALA, Biletan, Lipoicin, Thioctan, and many other names.
Alpha-lipoic acid is a naturally occurring fatty acid that can be found in many foods such as yeast, spinach, broccoli, potatoes, and organ meats such as liver or kidney.
Alpha-lipoic acid has been used in alternative medicine as a possibly effective aid in weight loss, treating diabetic nerve pain, healing wounds, lowering blood sugar, improving skin discoloration caused by vitiligo, and decreasing complications of coronary artery bypass graft (CABG) surgery. Alpha-lipoic acid may have been combined with other plants or extracts in a specific preparation to treat these conditions.
Alpha-lipoic acid has also been used to treat rheumatoid arthritis, Alzheimer’s disease, alcoholic liver problems, altitude sickness, heart-related nerve problems, HIV-related brain problems, or eye problems caused by diabetes. However, research has shown that alpha-lipoic acid may not be effective in treating these conditions.
Other uses not proven with research have included treating glaucoma, migraine headaches, high blood pressure, heart failure, dementia, carpal tunnel syndrome, leg pain caused by sciatic nerve damage or peripheral artery disease (PAD), anti-aging of the skin, and other conditions.
It is not certain whether alpha-lipoic acid is effective in treating any medical condition. Medicinal use of this product has not been approved by the FDA. Alpha-lipoic acid should not be used in place of medication prescribed for you by your doctor.
Alpha-lipoic acid is often sold as an herbal supplement. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.
Alpha-lipoic acid may also be used for purposes not listed in this product guide.
Alpha-lipoic acid Information | Mount Sinai
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Melhem MF, Craven PA, Liachenko J, et al. Alpha-lipoic acid attenuates hyperglycemia and prevents glomerular mesangial matrix expansion in diabetes. J Am Soc Nephrol. 2002;13(1):108-116.
Melmed S, Polonsky KS, Larsen PR, Kronenberg HM. Williams Textbook of Endocrinology. 13th ed. Philadelphia, PA: Elsevier; 2016.
Mitkov MD, Aleksandrova IY, Orbetzova MM. Effect of transdermal testosterone or alpha-lipoic acid on erectile dysfunction and quality of life in patients with type 2 diabetes mellitus. Folia Med (Plovdiv). 2013;55(1):55-63.
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Nagamatsu M, Nickander KK, Schmelzer JD, et al. Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy. Diabetes Care. 1995;18(8):1160-1167.
Packer L, Kraemer K, Rimbach G. Molecular aspects of lipoic acid in the prevention of diabetes complications. Nutrition. 2001;17(10):888-895.
Packer L, Tritschler HJ, Wessel K. Neuroprotection by the metabolic antioxidant alpha-linoic acis. Free Radic Biol Med. 1997;22(1-2):359-378.
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Panigrahi M, Sadguna Y, Shivakumar BR, et al. Alpha-Lipoic acid protects against reperfusion injury following cerebral ischemia in rats. Brain Res. 1996;717(1-2):184-188.
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Segermann J, Hotze A, Ulrich H, et al. Effect of alpha-lipoic acid on the peripheral conversion of thyroxine to triiodothyronine and on serum lipid-, protein- and glucose levels. Arzneimittelforschung. 1991;41(12):1294-1298.
Tatar A, Korkmaz M, Yayla M, et al. Anti-inflammatory and anti-oxidative effects of alpha-lipoic acid in experimentally induced acute otitis media. J Laryngol Otol. 2016;130(7):616-623.
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Alpha Lipoic Acid Benefits & Side Effects
Nutrition seems to be an ever-changing industry. As more research is conducted, more and more nutrients and their benefits are being discovered. One such nutrient that has been gaining popularity over the last few years is alpha lipoic acid (ALA). From metabolic support to brain health, ALA can impact several aspects of health and everyday life.
What Is Alpha Lipoic Acid?
Alpha lipoic acid is an antioxidant, or a natural, vitamin-like chemical. Known as the “universal antioxidant,” ALA is found naturally inside every cell of the human body. The mitochondria produce this antioxidant in small amounts, but that amount tends to decrease with age. ALA is both a water and fat-soluble nutrient, meaning it can make its way into and function in any part of the body. This potent antioxidant can be found in red and organ meats (liver, heart, kidney, etc.), potatoes, tomatoes, spinach, broccoli, peas, Brussels sprouts, and rice bran.
What Are the Benefits of Alpha Lipoic Acid?
Now, you can give your patients an eye vitamin designed to help support eye health in people with blood glucose control issues that includes alpha lipoic acid.
As a potent mitochondrial antioxidant, alpha lipoic acid helps produce energy for normal bodily functions by converting blood glucose. Often, damaged and defective mitochondria are the first sign of health issues, and ALA helps protect these cell powerhouses from free radical damage. Most commonly, practitioners use ALA to help patients with blood glucose control issues with nerve damage-related symptoms like extreme pain, tingling, and/or numbness. Moreover, it has been shown to improve blood glucose control and microcirculation in the limbs and reduce insulin resistance and risk of eye health concerns caused by poorly-controlled blood glucose.
Beyond poor blood glucose control and the issues that come with it, ALA can help reduce damage, inflammation, and oxidative stress in several areas of the body, including the brain, eyes, and heart. It recycles and helps restore levels of other vitamins like Vitamins C and E and CoQ10, helps prevent certain kinds of cell damage, and plays a role in:
- Reducing signs of aging on the skin
- Weight loss
- Improving fat metabolism
- Reducing blood pressure
- Reducing migraines
- Improving cholesterol
- Lowering risk of heart disease
- Alleviating pain
Are There Any Known Alpha Lipoic Acid Side Effects?
Alpha lipoic acid is considered generally safe for adults to consume, but the most common negative reaction from supplementing ALA is a skin rash. Other reactions include:
- Tingling or pins and needles sensation
- Muscle cramps
Patients with blood glucose control issues may need to adjust other medications as ALA reduces blood glucose levels. Though rare, other interactions include medications that manage under and over-active thyroid issues and the actions of the vitamin biotin.
Although the body does produce alpha lipoic acid on its own, it may be a good idea for patients to include this nutrient in their daily vitamin regimen, especially if they have blood glucose control issues or other health concerns improved by ALA. Scientists need to conduct more research to confirm all the potential benefits of this powerful antioxidant.
- “Alpha-Lipoic Acid: Uses, Side Effects, Interactions, Dosage, and Warning.” WebMD, WebMD LLC., 2018, www.webmd.com/vitamins/ai/ingredientmono-767/alpha-lipoic-acid.
- Wong, Cathy. “Health Benefits of Alpha Lipoic Acid.” Edited by Richard N. Fogoros, Verywell Health, About, Inc., 12 Oct. 2018, www.verywellhealth.com/alpha-lipoic-acid-88727.
- Raman, Ryan. “Alpha-Lipoic Acid: Weight Loss, Other Benefits and Side Effects.” Healthline, Healthline Media, 19 Sept. 2018, www.healthline.com/nutrition/alpha-lipoic-acid.
- Cohen, Joe. “30 Proven Alpha Lipoic Acid Benefits + Side Effects, Dosage. ” Selfhacked, Selfhacked, 2 Oct. 2018, www.selfhacked.com/blog/lipoic-acid/.
- “Alpha Lipoic Acid.” Alpha Lipoic Acid | Michigan Medicine, Healthnotes, Inc., 23 May 2015, www.uofmhealth.org/health-library/hn-2799001.
- “Alpha Lipoic Acid.” Edited by Brittany Poulson and Joanna Wilkins, Alpha Lipoic Acid – Health Encyclopedia – University of Rochester Medical Center, University of Rochester Medical Center Rochester, NY, 2018, www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=19&contentid=AlphalipoicAcid.
Photo credit: Pieter Pieterse on VisualHunt.com / CC BY-NC-ND
Supplements with Similar Side Effects as: Alpha-Lipoic Acid | Complementary and Alternative Medicine
Below is a list of side effects for this supplement along with supplements with similar side effects.
blood sugar, low
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ALPHA LIPOIC ACID (ALSO KNOWN AS ALA) – Neuroneeds
Alpha Lipoic Acid Summary
Alpha lipoic acid (ALA) is produced in small amounts by humans, and thus is not a true vitamin. It is an essential cofactor for many enzymes related to energy metabolism, and activates the insulin-signaling cascade to help lower blood sugar. However, its primary use in ASD and in other conditions is as a powerful antioxidant. It the later capacity, in part it serves to regenerate active forms of glutathione, and vitamins C and E following their uses. The role of ALA in the treatment of autism is not well studied, and is mostly driven by the desire to provide mitochondrial support and by its antioxidant properties in ameliorating an underlying metabolic, redox, or mitochondrial condition. ALA is also sometimes recommended for treating a wide range of other neurological conditions. While any supplement taken into the stomach can cause nausea, ALA is well known for this. Due to its effects on insulin metabolism, people with diabetes and/or hypoglycemia should be careful as alpha-lipoic acid might lower their blood sugar. While studies are few, the clinical experience of many expert physicians, and the generally benign nature of ALA supplementation have convinced some experts to offer ALA supplementation to their patients with an ASD, especially in those with signs of mitochondrial dysfunction.
Alpha Lipoic Acid details
What is Alpha Lipoic Acid?
Alpha lipoic acid (ALA) is a fatty acid that acts as a strong antioxidant. While it is an essential compound, it can be produced in small amounts by humans, and thus is not a true vitamin.
at does Alpha Lipoic Acid do?
Alpha lipoic acid is an essential cofactor in the pyruvate dehydrogenase enzyme complex that is a critical step in carbohydrate metabolism. ALA is also a required cofactor for enzymes in the Krebs cycle, and in the metabolism of branched-chain amino acids and glycine. ALA has been found to activate the insulin-signaling cascade and increase glucose uptake in cultured fat and muscle cells. It main interest as a supplement, however, is that of a powerful antioxidant. It the later capacity, it serves to regenerate active forms of glutathione, and vitamins C and E following their uses.
What does anAlpha Lipoic Acid deficiency appear as?
Alpha lipoic acid is synthesized by human cells, and deficiency of this nutrient is unknown, except in rare metabolic disorders affecting enzymes in ALA biosynthesis, whereas it presents as mitochondrial disease (https://www.ncbi.nlm.nih.gov/pubmed/24777537).
What about Alpha Lipoic Acid’s use in Autistic Spectrum Disorders (ASD)?
The role of alpha lipoic acid in the treatment of autism is not well studied. ALA is often used as part of a regiment for mitochondrial disease due to its many effects in energy metabolism. However, its use of in ASD is mostly driven by its antioxidant properties in ameliorating an underlying defect on reactive oxygen species (ROS or redox) metabolism and/or mitochondrial dysfunction. Several lines of evidence support the notion that some children with ASD have abnormal redox metabolism (this topic is reviewed in https://www. ncbi.nlm.nih.gov/pmc/articles/PMC4910649/pdf/cmped-10-2016-043.pdf), including abnormal glutathione metabolism. Oxidative damage to proteins has been documented in the brain and other tissues in ASD. Redox abnormalities have been linked to mitochondrial dysfunction in children with ASD, and mitochondrial dysfunction is one of the most prevalent metabolic disorders in ASD. Biomarkers suggestive of mitochondrial dysfunction are identified in 30% or more of children with ASD, while about 5% meet strict criteria for a diagnosis of classical mitochondrial disease. In support of this high prevalence of mitochondrial dysfunction in ASD are two studies that found lower than normal electron transport chain function in immune cells from 80% of the children with ASD examined (https://www.ncbi.nlm.nih.gov/pubmed/?term=21119085; https://www.ncbi.nlm.nih.gov/pubmed/?term=24753527). Some of the signs that a given individual with ASD is more likely to have abnormal redox metabolism and/or mitochondrial dysfunction are the presence of chronic pain, increased fatigue on the day following unusual exertion, severe gastrointestinal disease, dysautonomia, or a history of regression (including any loss of abilities, whether transient or persistent). This list is incomplete, and you may want to consult with your physician; laboratory testing can also help.
What about Alpha Lipoic Acid’s use in other conditions?
Alpha-lipoic acid supplements have been used in Europe and elsewhere for certain types of nerve damage, especially that related to diabetes. Several studies have shown that ALA can improve insulin resistance. There is some data that long-term use of alpha lipoic acid might help with oxidative damage related to aging (including its use in skin creams). Other uses include in Amanita mushroom poisoning, glaucoma, retinal disorders, cataracts, kidney disease, migraines, memory loss, chronic fatigue syndrome, cancer, liver disease, cardiovascular diseases, HIV/AIDS, Lyme disease, and obesity.
What are the common and/or important side effects of Alpha Lipoic Acid?
While any supplement taken into the stomach can cause nausea, alpha lipoic acid seems to be a frequent offender. Thus, medical care providers often recommend a lower dose at first, which is increased over time. Due to its effects on insulin metabolism, people with diabetes and/or hypoglycemia should be careful as alpha-lipoic acid might lower their blood sugar.
Is there any laboratory testing for an Alpha Lipoic Acid Deficiency?
Testing is neither generally available nor of apparent clinical utility outside of consideration of a metabolic defect in ALA biosynthesis.
Additional Dosing Beyond Spectrum Needs
Because of the potential for nausea, the dosage of ALA in Spectrum Needs (150 mg a day in adults) is lower than the 400 mg a day in adults often recommended for mitochondrial disease. Thus, you may wish to speak to your health care provider regarding additional ALA supplementation beyond Spectrum Needs if your child has been diagnosed with a proven or suspected mitochondrial disorder.
How and why Alpha Lipoic Acid is used in Spectrum Needs
ALA is added in order to provide a wide basis of nutrition, especially given its important role in energy metabolism, and for its antioxidant properties in ameliorating an underlying defect of redox/ROS/free radical metabolism or mitochondrial dysfunction. Because of frequent nausea and the potential for toxicity, Spectrum Needs relatively low dose of ALA. Side effects are unexpected at these dosages.
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Dosage, Side Effects & Supplements
Alpha Lipoic Acid – also known as Thioctic acid, Lipoic Acid or just ALA – is best known for being a powerful antioxidant, helping protect cells against harmful free radicals. But studies have suggested that its benefits go beyond free radical neutralization, and can extend to weight loss, diabetes (specifically, neuropathy) and skin damage.
Supplement companies have seized on a growing number of these studies. You now see Lipoic Acid in multivitamins, anti-aging supplements (due to the nutrient’s antioxidant properties) and even in pet food!
We’ll go over Alpha Lipoic Acid’s various claims and see what’s supported by strong evidence… and what’s better left for further research. We’ll also take a closer look at Alpha Lipoic Acid’s side effects, dosage information, and how foods rich in the nutrient compare with Acid supplements.
Alpha Lipoic Acid uses and benefits
Like CoEnzyme Q10, Alpha Lipoic Acid is produced naturally in the body, and isn’t technically a “vitamin” (something that is essential to your body, but is produced in low-enough quantities to warrant supplementation via diet or supplements). Also like CoQ10, it’s a vital nutrient that a) has antioxidant properties and b) helps generate energy in cells.
As a refresher, antioxidants help fight off free radicals – unstable elements in cells that are generated through natural and unnatural means, like energy production and smoking. Free radicals can cause other elements to become unstable, creating harmful chain reactions that eventually lead to major diseases such as heart disease and cancer.
Related reading: What are Free Radicals and Antioxidants?
Alpha Lipoic Acid and weight loss
Several meta-analyses (studies of other studies) have found some minor benefits when participants took Alpha Lipoic Acid for weight loss,,. Though there were “slight” decreases in weight, we don’t recommend taking the nutrient simply to shed some pounds.
Why? Well first, the average amount of pounds lost is just that – an average. It doesn’t mean you’ll see the same effects. We don’t know much about individual participants in these studies – their conditions, weight, deficiencies and other factors during the study. Second, dosages vary per study, further complicating things.
These “slight” decreases in weight also happened over the course of 14+ weeks. In this case, exercising is simply more effective.
Alpha Lipoic Acid and diabetes
A number of studies have shown the effectiveness of Alpha Lipoic Acid on nerve damage caused by diabetes (called diabetic neuropathy),. Though, even evidence like this should be taken with a grain of salt. (We know, we are quite the scientific skeptics.)
The Linus Pauling Institute notes that many of these studies have been conducted by a German research group funded by a Lipoic Acid manufacturer. It’s always prudent to ask what the agenda was behind a study. Unfortunately, most of the time this is unknown to the general public!
Alpha Lipoic Acid and skin damage
A number of studies over the last two decades suggest Alpha Lipoic Acid’s antioxidant properties make it a potent ingredient in topical creams, treating ageing skin, and protecting against skin cancer and UV radiation.
One study found that topical Alpha Lipoic Acid “is a powerful anti-ageing agent under the appropriate usage”, while another found reduction in facial lines and improvement in skin color in most participants, with no peeling or “other apparent adverse side effects”.
This claim isn’t without contradictory studies. One overview of Alpha Lipoic Acid as a topical agent found the nutrient ineffective for “skin cancer and photoaging changes”, but mentioned other nutrients – Vitamin C and Vitamin E – were more beneficial in this case.
How much Alpha Lipoic Acid do you need?
Here’s the unsettling thing about Alpha Lipoic Acid dosing: some excellent sources can’t seem to agree with one another. Healthline suggests 300mg-600mg. University of Rochester Medical Center simply cites that doses range from 200mg-800mg. The Linus Pauling Institute recommends 200mg-400mg for “generally healthy people”.
So should you be taking 300mg of Alpha Lipoic Acid? 600mg? And what are “generally healthy people” anyway? The point isn’t that these sources are misleading. Simply there are no set averages established for what most people should be taking.
At Rootine, we stay away from averages as best we can. Our lifestyle assessment quiz, along with the results from your at-home DNA kit help us dose Alpha Lipoic Acid and other nutrients for your specific needs. To learn more about the process that goes into creating your daily nutrient packets, see our Science page.
Can you be deficient in Alpha Lipoic Acid?
You can be deficient in Alpha Lipoic Acid if you have certain gene variations that you’ve inherited from your parents. These genes include: NQO1, GSTP1, SOD2, and APOE. At Rootine we look at every person’s DNA on a case-by-case basis to determine what nutrients you need.
Can you take too much Alpha Lipoic Acid?
In studies that administered anywhere from 600mg-1,200mg of Alpha Lipoic Acid for several years, no serious side effects were reported; shorter-term administration of much higher doses (2,400mg) also didn’t produce series symptoms. Minor Alpha Lipoic Acid side effects in these studies included itchy skin, rashes, abdominal pain, nausea, vomiting and diarrhea.
These doses weren’t particularly harmful, but they were excessively high in some cases. High doses are sometimes necessary to treat conditions or deficiency, which is why Rootine’s included DNA kit is so important for determining how much Alpha Lipoic Acid you need.
Alpha Lipoic Acid in food vs. supplements
Both meat and veggies contain tiny amounts of Alpha Lipoic Acid. To give you some perspective: supplements can contain 1,000x the Alpha Lipoic Acid you’d get from food (which includes various types of veggies and meat).
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Our personalized nutrient packets include Alpha Lipoic Acid and up to 17 other vital nutrients – all dosed according to DNA kit results and lifestyle assessment. To see what’s included in your monthly subscription of Rootine vitamins and minerals: View Rootine Products
90,000 Alpha Lipoic Acid – How to Take?
Alpha Lipoic Acid is an organosulfur compound with powerful antioxidant properties. It is synthesized in the human body and enters it with some products. Antioxidant properties are realized in two ways: direct – by neutralizing free radicals, indirect – by increasing the concentration of glutathione inside the cell and increasing the activity of superoxide dismutase. …
Attention! Alpha lipoic acid can be referred to as lipoic acid or thioctic acid.
Benefits of Alpha Lipoic Acid
Alpha lipoic acid is similar to B vitamins in terms of the spectrum of biochemical effects on the body.
Lipoic acid is involved in fat metabolism, stimulates cholesterol metabolism. Vitamin-like substance promotes weight loss by dulling hunger, increasing energy production, improving glucose absorption, increasing tissue sensitivity to insulin. It participates in the release of energy from glucose, which allows the body to more efficiently waste the beneficial components obtained from food, without storing them for a rainy day.
Lipoic acid is part of the anti-age complex Siberian Wellness – Organic Germanium – Essential Minerals. A powerful complex with organic germanium, resveratrol and natural antioxidants helps to comprehensively rejuvenate the body, slowing down the aging process and saturating tissues with oxygen.
If we are talking about antioxidants, then we cannot but recall the legendary complex with a 30th history from Siberian Wellness – Novomin.The increased content of vitamins A, E and C helps the body to support immunity and provide antioxidant protection, which is especially important during epidemics of flu and colds.
Indications for use
Alpha lipoic acid is rapidly absorbed by nerve, brain, and heart cells. This allows it to be used not only as a sports nutrition, but also as a drug in the treatment of many diseases. It improves liver function, has a hypoglycemic, hypocholesterolemic effect, and improves the nutrition of nerve cells. It is included in prescription drugs, dietary supplements, and sports nutrition.
Instruction for use
As part of dietary supplements, dosages from 20 to 100 mg are usually used. Although these doses are considered smaller than those used in most prescription drugs, it is still advisable to consult your doctor. They are taken 1, maximum 2 times a day. As part of sports nutrition, high dosages of 300 or 600 mg can already be found, so a doctor’s consultation is necessary. Uncontrolled consumption of thioctic acid supplements may lead to hypoglycemia or reduce the effectiveness of hormonal treatments.
It is recommended to take it 30 minutes before meals.
Not recommended for use with alcohol. Since metal ions bind lipoic acid, then when taking medications or dietary supplements of iron, magnesium, calcium, it is necessary to observe an interval of 2 hours between them. The same applies to dairy products, because they contain calcium.
For adults, the Siberian Wellness complex – Chronobiological protection of the heart – Synhrovital III is recommended as a source of lipoic acid, beta-glucans, selenium and lycopene, as well as an additional source of vitexin. It provides comprehensive cardioprotection, allows you to get the daily requirement of lycopene and essential antioxidants.
Contraindications and adverse reactions
Lipoic acid should not be taken by children, during pregnancy and breastfeeding, if there is sensitivity to certain components.
Attention! Side effects such as nausea and dizziness may occur, very rarely – allergic reactions. Diabetics are advised to regularly monitor blood glucose, since lipoic acid can enhance the effect of hypoglycemic agents.
90,000 what is it, how to take to lose weight?
Weight loss with the use of additional drugs is gaining more and more popularity. One such supplement is alpha lipoic acid.It is a natural natural antioxidant found in many foods. The body also synthesizes it, but in very small quantities. The main advantage of dietary supplements with this substance is to promote weight loss without stress for the body.
What is Alpha Lipoic Acid?
Alpha lipoic acid is a pharmacy vitamin-like preparation. The active substance is in the form of a yellow crystalline powder. It is water-soluble and has a bitter taste.
Most often, the product is available in tablets, capsules and powder. But there are also solutions for injections. When losing weight, you can use dietary supplements of any form of release.
Effects on the body
When losing weight, alpha-lipoic acid works in several directions at once, so the desired effect is obtained:
- Reduces appetite, which helps with various diets, when there is a risk of breakdown. The substance is prescribed for diabetics, since the drug helps to normalize lipid and carbohydrate metabolism.
- Reduces body fat mass. These are not fat burners, as marketers of dietary supplements claim. The substance simply does not allow new fat cells to be deposited, since it converts carbohydrates into energy.
- Cleans the body. Participates in the elimination of toxins, toxins, heavy metal salts. Oxidises the metabolic products of fatty acids and correctly removes them from the body.
When using the drug, precautions must be taken.He has contraindications, so it is better to initially consult a doctor.
For alpha lipoic acid to help, you need sports, exercise, adequate nutrition and other nuances of the process of losing weight. The dosage should be as follows:
- For simple physical activity without a goal to reduce weight, 50 mg of the substance per day is sufficient.
- If there is an active weight loss – 200 mg at a time daily.
- It is not recommended to consume more than 600 mg per day. They should be divided into 3 steps.
- It is better to increase the concentration gradually, starting from 50-100 mg and increasing to 600.
The best time to take is in the morning or immediately after training. You need to drink the medicine on an empty stomach, half an hour before meals.
Attention! When taken, tablets and capsules must be swallowed without chewing, and immediately washed down with clean water.
When using lipoic acid, the reaction of the body is not entirely expected. Side effects are rare, but if they occur, you must stop taking the supplement and consult a specialist. The following adverse reactions are observed:
- aversion to food, complete loss of appetite;
- persistent headaches;
- increased sweating and at the same time dry mouth;
- sleep problems.
So that they do not lead to serious health problems, it is necessary to take measures, and first of all to cancel the drug.
It is not recommended to take alpha lipoic acid in the following cases:
- during pregnancy and lactation;
- for allergic reactions and individual intolerance to the drug;
- with high blood pressure;
- when taking certain medications.
90,065 children under 16;
90,065 adults over 60;
Attention! Alpha Lipoic Acid is just a fat-burning aid. To lose weight, you still need physical activity and proper nutrition.
About the company – Esparma
TRADITSIS & INNOVATSIS
Pharmaceutical company “esparma GmbH” (Nimechchina) viroblyaє lykarskі drugs already for 130 years, and in 2009 it will enter the warehouse of the great multinational pharmaceutical company “Aristo pharma GmbH” with its center in Berlina.
All the company’s rockets follow the principle: create high-quality preparations, so that you can harmoniously meet in your own superior tradition of good pharmaceuticals and modern innovations.
SERTIFIKOVANE EVROPEYSKE VIROBNITSTVO
It is essential that the cycle of virob production of drugs “esparma GmbH” is working in Europe.
The head strategy of the company is a turbot about the health of the patient.
Adopting the concept of the concept, “esparma GmbH” will ensure the availability in Ukraine of the most effective preparations with a friendly profile of safety and at an affordable price.
PREPARATIONS “esparma GmbH”, SCHO REVIRENI HOUR
The company focuses its respect on drugs, the efficiency of which is brought and revised in an hour. The preparations of “esparma GmbH” can prove a broad base and with success in stagnating in endocrinology, neurology, therapy, urology, gynecology, pediatrics, orthopedics, phlebology.
Sered bestseller drugs – brandy types: ESPA-LIPON, BLEMAREN, APIZARTRON, ESKUZAN, EVKABAL
The portfolio of the company “esparma GmbH” includes a wide range of licars:
- ESKUZAN – natural vidomy against varicose veins.
- EVKABAL – a series of preparations in the form of cold, cough and undead for all the motherland – SYRUP, BALM, SACHE and NAZALNI form.
- BLEMAREN – the gold standard for citrate therapy for ailments.
- ESPA-FOCIN is a topical antibiotic for cystitis treatment.
- CYSTO-AURIN – natural uro-antiseptic against cystitis
- APIZARTRON – for a long time now it has been a popular ointment based on bdzholin ointment for treating injuries and ailments of the cysto-myaze system.
- SUSTAMAR is a natural salty due to the antiapal, zest-borne and chondroprotective effect in case of ailments of the slopes and the ridge.
- ESPA-LIPON is a universal antioxidant (treatment of neuropathies during a period of time, especially in case of diabetic diabetes), as well as a hepatoprotector and detoxifier (hepatitis, cirrhosis).
- BALZAMED – a drug complex (Active, Intensive) for looking after the problematic feet.
- ESPA-CARB (carbimazole) is an antithyroid drug for the treatment of hyperthyroidism with a reduced tolerance profile.
- SEDARISTON is a complex phytopreparation on the basis of valerian and sound effects.
The esparma GmbH’s seasonal preparations occupy one place in the European pharmaceutical market and deserve to be cried as a leader and a good fortune in Ukraine among women and patients.
Thiolepta or Alpha Lipoic Acid? – meds.is
Comparison of the effectiveness of Thiolepta and Alpha Lipoic Acid
The efficacy of Thiolepta is quite similar to Alpha Lipoic Acid – this means that the ability of the drug to have the maximum possible effect is similar.
For example, if the therapeutic effect of Tiolepta is more pronounced, then when using Alpha Lipoic Acid, even in large doses, it will not be possible to achieve this effect.
Also, the rate of therapy – an indicator of the rate of therapeutic action in Tiolepta and Alpha-lipoic acid is approximately the same. And bioavailability, that is, the amount of a medicinal substance reaching the site of its action in the body, is similar. The higher the bioavailability, the less its losses will be during assimilation and use by the body.
Safety Comparison of Thiolepta and Alpha Lipoic Acid
The safety of the drug includes many factors.
At the same time, in Tiolepta, it is quite similar to Alpha Lipoic Acid. It is important where the drug is metabolized: medicinal substances are excreted from the body either unchanged or in the form of products of their biochemical transformations. Metabolism occurs spontaneously, but most often it involves major organs such as the liver, kidneys, lungs, skin, brain, and others.When evaluating metabolism in Thiolepta, as well as in Alpha-lipoic acid, we look at which organ is metabolizing and how critical the effect on it is.
Risk-to-benefit ratio is when prescribing a medicinal product is undesirable, but justified under certain conditions and circumstances, with mandatory caution in use. At the same time, Tiolepta does not have any risks when used, as well as Alpha Lipoic Acid.
Also, when calculating safety, it is taken into account whether only allergic reactions or possible dysfunction of the main organs are manifested.In other matters, as well as the reversibility of the consequences of the use of Thiolepta and Alpha Lipoic Acid.
Comparison of the contraindications of Thiolepta and Alpha Lipoic Acid
Based on the instructions. The number of contraindications for Tiolepta is quite similar to Alpha Lipoic Acid and is small. This is a list of symptoms with syndromes, and diseases, various external and internal conditions under which the use of Thiolepta and Alpha Lipoic Acid may be undesirable or unacceptable.
Addiction Comparison between Thiolepta and Alpha Lipoic Acid
Like safety, addiction also includes many factors that must be considered when evaluating a drug.
So the set of values of such parameters as “withdrawal syndrome” and “development of resistance” in Tiolepta is quite similar to those in Alpha lipoic acid. Withdrawal syndrome is a pathological condition that occurs after the termination of the intake of substances that cause addiction or dependence into the body.And by resistance is meant the initial resistance to the drug, in this it differs from addiction, when the resistance to the drug develops over a certain period of time. The presence of resistance can be ascertained only if an attempt was made to increase the dose of the drug to the maximum possible. At the same time, Tiolepta’s values of “withdrawal syndrome” and “resistance” are quite small, however, as well as in Alpha-lipoic acid.
Comparison of the side effects of Thiolepta and Alpha Lipoic Acid
Adverse events or adverse events are any medically adverse event experienced by a subject following administration of a drug.
Tiolepta’s adverse event status is almost the same as that of Alpha Lipoic Acid. They both have few side effects. This implies that the frequency of their manifestation is low, that is, the indicator of how many cases of manifestation of an undesirable effect from treatment is possible and registered is low. The undesirable effect on the body, the strength of the influence and the toxic effect of Tiolepta are similar to Alpha-lipoic acid: how quickly the body will recover after taking it and whether it will recover at all.
Ease of Use Comparison of Thiolepta and Alpha Lipoic Acid
This is the selection of the dose, taking into account various conditions, and the frequency of receptions. At the same time, it is important not to forget about the form of release of the drug, it is also important to take it into account when drawing up an assessment.
Ease of use for Tiolepta is about the same as for Alpha Lipoic Acid. However, they are not convenient enough to use.
The drug rating is compiled by experienced pharmacists studying international research.The report is generated automatically.
The guide was last updated: 2020-12-04 13:42:52
(PDF) New opportunities for the use of alpha-lipoic acid: the role of enantiomers
Vol. 15, No. 6, 2019
Literature Review /
mi. The most complete enumeration of them is given in P. Kempler’s classification in
[16, 17]. So, with
cardiovascular DN, tachy can be observed –
cardia of rest, fixed rigid heart –
rhythm (heart denervation syndrome), orthostatic hypotension, painless ischemia and infarction
hypersensitivity to catecholamines, decrease
exercise tolerance, changes
ECG (dispersion of the ST interval, lengthening of the interval –
la QT, inversion of the positive T wave, pseudo –
coronary ST segment elevation), cardiorespiratory 2 –
arrest, left ventricular dysfunction,
edematous syndrome, sudden death.Autonomous
DN with the involvement of the digestive organs is manifested by hypersalivation, hypo- and atony of the stomach
(gastroparesis), atony of the esophagus, hypomotoric
of the intestine, functional hypoacidosis, ref-
lux-esphagitis. With the addition of
dysbiosis, diarrhea is noted (diabetic
enteropathy). In addition, there may be gallbladder atro-
and biliary dyskinesia
with a tendency to cholelithiasis, reactive pancreatitis
atitis, abdominal pain syndrome .
The key to success in the prevention and treatment of any complications of diabetes
, including DN, is the normalization of carbohydrate metabolism, which is achieved
by prescribing a diet, insulin therapy, per-
antihyperglycemic drugs, depending on
from the type of diabetes and the depth of impairment of glucose tolerance
. Therefore, having identified a patient with DN, a non-
urologist should ask when the patient last consulted an endocrinologist at
and, if necessary, prescribe such a consultation
in order to correct antihyperglycaemic therapy.
Particular attention should be paid to avoiding significant fluctuations in glucose levels (jumps) during the day
, for example, from 3.3 to 14 mmol / L [20, 21].
It should be remembered that the more acutely the manifestations of neuropathy develop
, the faster and more completely
they stop when compensation is reached
mononeuropathies, which often do not require
prescription of additional drug therapy,
pii, but stop spontaneously, are especially favorable.If the symptoms
DN develop gradually and bother the patient
for a long time, then only by stabilizing the
glycemic profile it is not possible to influence the neuropathia. In such cases, the treatment algorithm
DN provides for the following types of therapy:
– pathogenetic – prescription of drugs
alpha-lipoic (thioctic) acid and vitamins
group B – thiamine, pyridoxine, cyanocobala –
– symptomatic – prescribing adjuvan-
analgesics from the tricyclic class an-
tidepressants, serotonin reuptake inhibitors
, ion channel blockers (anti-
convulsive, antiarrhythmic drugs), use 9000 and 9000 topical agents, such as
such as capsaicin, to block certain
mechanisms of neuropathic pain development; when
severe pain form of DN, resistant to
therapy, potent opiates
can be used ;
At present, practically the only
, well substantiated from the point of view of the pathogenesis of DN
, the possibility of drug treatment consists in prescribing alpha-lipoic (thi-
octoic) acid preparations. ALA is a natural endogenous
substrate of the body, which is a cofactor
of many reactions of energy metabolism and antioxidant protection
. Multiple pharmacological effects of thioctic acid are manifested in
optimization of processes of cellular energy production
, carbohydrate, lipid, protein metabolism
[3, 7, 15, 21, 23].As a coenzyme of the enzyme complex
of the mitochondrial plexus, α-lipoic acid participates
in the work of the Krebs cycle and oxidative decarboxylation of branched-chain amino acids
promotes the utilization of lactate with the formation of
pyruvate, preventing pyruvate. The positive
effect of thioctic acid on the metabolism of carbohydrates
is manifested in a decrease in the intensity of glucone-
genesis and ketogenesis, glycosylation of proteins, ac-
activation of glucose oxidation processes, reduction of hyperinsulinemia and insulin resistance
(restoration of glulinemia and insulin resistance) 9000
ALA has an insulin-like effect:
promotes the absorption and utilization of glucose
in insulin-dependent and independent tissues and enhances the interaction of insulin with its receptors.
While taking ALA, lipid metabolism is optimized
: the concentration of fatty acids,
cholesterol and triglycerides in blood plasma decreases, the intensity of lipolysis processes decreases. In addition, ALA
improves the protein-synthetic function of the liver.
After oral administration, ALA is absorbed in the
gastrointestinal tract and transported
to various organs, in particular to the brain,
due to its ability to freely cross the blood-brain barrier
Depending on the source of origin, ALA is converted in the liver into various metabolites, such as
bisnorlipoate and tetranorlipoate. It should be noted,
, that all positive biological effects are provided by the R (+) – enantiomer of ALA.It is believed that
some systems are associated with cell transport
ALA volume – in particular, sodium-dependent transport system
, a transmembrane protein produced by the SLC5A6 gene
. Both transporters are also
responsible for the intestinal absorption of ALA. With
this R (+) – or S (-) – enantiomers of ALA are
competitors for transport systems, which can
affect the bioavailability and clinical efficacy of racemic mixtures of ALA .
With DN, the use of ALA allows you to influence several pathogenetic links at once,
helping to reduce the formation of products
Alpha-lipoic acid forte 100mg Vitamir tablets 618mg 30pcs
Alpha-lipoic acid is a powerful antioxidant, … It is produced by every cell of our body, but this amount is not enough for the normal functioning of internal systems. There are practically no contraindications and side effects to the use of alpha-lipoic acid.It performs several vital functions: it neutralizes the action of free radicals, protects cells from the destructive action of oxidation products, helps to slow down the development and prevent the appearance of malignant tumors, diabetes, and atherosclerosis.
Alpha lipoic acid affects the areas of the brain responsible for appetite; reduces hunger; stimulates energy consumption; qualitatively improves the absorption of glucose by cells, reducing its level in the blood; reduces the liver’s tendency to accumulate fat; increases insulin sensitivity.The slimming effect is enhanced by physical activity and a balanced diet. After losing weight, there are no stretch marks on the skin. Alpha lipoic acid is ineffective as the only remedy for overweight, therefore it is recommended to take it in combination with a protein diet and exercise.
Alpha lipoic acid is one of the few drugs recommended for people with diabetes, including for weight loss. By promoting weight loss, it also improves overall well-being, stomach health and vision.It is able to relieve chronic fatigue, increase activity, therefore its reception is recommended for those who lead an active lifestyle and play sports.
Alpha Lipoic Acid has been shown to slow the aging process. Therefore, doctors recommend taking it as a means to prolong youth.
By the nature of the biochemical action, alpha-lipoic acid is similar to vitamins of group B – it helps to remove molecules of toxic substances and heavy metals from the body, to restore the nervous system and immunity.It is used for various intoxications, including alcohol. The content of alpha lipoic acid in the body is also very important for the proper functioning of the thyroid gland.
Alpha lipoic acid is recommended for: obesity, chronic fatigue, visual impairment, pathology of the cardiovascular system, diabetes mellitus, atherosclerosis, alcoholism, macular degeneration of the retina, Alzheimer’s disease.
The inulin contained in Alpha Lipoic Acid Forte 100 mg VITAMIR® is a prebiotic. Provides protection against dysbiosis and pathogenic bacteria, normalizes digestion and metabolism, has a general beneficial effect on the body, strengthens the immune system.
Alpha lipoic acid: what is it? For what?
The properties of lipoic acid and its effects on the body are extensive. This acid is best known for its antioxidant properties. Scientists from Moscow State University have shown that alpha-lipoic acid can increase the resistance of nerve cells to neurodegenerative disorders. The study was published in the journal Frontiers in Neuroscience . 1 Its results can help in the creation of drugs for the treatment of diseases associated with disorders of the nervous tissue.
In the course of several studies, the effect of lipoic acid on increasing blood circulation has been confirmed. 2
Regarding weight loss, in obese people, weight loss was observed in those who took 1800 mg of lipoic acid, 3 However, more research is needed to be sure that this supplement promotes weight loss. … It slows down the accumulation of body fat, but you need to understand that if you want to lose weight, you cannot rely on supplements alone.This drug should only be considered as an adjunct to exercise and diet.
It is also used to prevent and protect against infections and viruses. It takes part in many biochemical processes in the body: it regulates fat and carbohydrate metabolism, promotes detoxification of the body after drinking alcohol, from toxic substances and heavy metals.
It is often prescribed as an additional agent to reduce the side effects of the main drugs in the treatment of various diseases.
The additive has a beneficial effect on the nervous system, reduces emotional stress.
This acid plays an essential role in the conversion of glucose into energy.
Alpha Lipoic Acid is a versatile antioxidant as it dissolves not only in water, but also in fat. Thanks to this property, it copes well with intracellular defense. In addition, it works well with other antioxidants such as vitamin C, glutathione, vitamin E, enhancing their effects.Also, science has proven the effectiveness of lipoic acid for memory problems.
Benefits for weight loss
Alpha Lipoic Acid has a remarkable property that will benefit anyone looking to reduce body fat and lose weight. It participates in the process of fat burning and promotes more active breakdown of fat cells during exercise. In addition, entering the body, lipoic acid enhances protein metabolism, due to which a person receives the required amount of energy.In doing so, however, a strict diet must be followed.
For weight loss, lipoic acid should be consumed in the morning before the first meal, after training, or at dinner. It is good to combine a serving of the supplement with a carbohydrate meal.
To achieve maximum effect, you should strictly monitor your basic diet. It should be balanced and fully meet your daily protein, fat and carbohydrate requirements. Avoid growing hunger.
Helps maintain muscle mass during the diet
Another potential benefit of CLA is its ability to maintain muscle mass while dieting.The best way to maintain muscle mass during a long-term calorie-restricted diet is to consume enough protein (1.6 g / kg +) with regular resistance training. However, CLA supplementation can help improve your results.
A two-year study examined the body composition of overweight adults. Those who received 4.5 g of CLA showed a decrease in fat mass and preservation of muscle mass. 4 However, it is worth noting that this biennium did not include diet and exercise monitoring.And when it comes to maintaining muscle while losing weight, these factors are important.
Supplement for athletes
Every athlete knows that in the process of training, one of the main tasks in building a beautiful body is the correct muscle recovery. Lipoic acid acts as an antioxidant and enhances human potential. When consumed, the production of heavy radicals decreases as a result of intense exercise in the gym. This allows the body to fully rest and grow.Regular use of lipoic acid will increase physical activity without losing performance. It also acts as an anti-catabolic, that is, it prevents proteins from being destroyed, which will have a beneficial effect on the effectiveness of your training process.
Application in cosmetology
Lipoic acid is actively used externally as a cosmetic product. In most formulations of anti-aging creams, it comes first.Lipoic acid gives the skin a healthy appearance, helps to maintain its tone and reduces the negative effects of prolonged exposure to the sun. It can be useful for skin diseases: dandruff and acne, as well as narrows pores and reduces inflammation. A double-blind study of forty participants found a marked reduction in signs of skin aging after six months of taking the supplement. 5
What foods contain?
The main sources of lipoic acid are animal products – heart, kidney and liver.It is also found in large quantities in various legumes: lentils, peas, beans. Small amounts of acid can be obtained from bananas, mushrooms, yeast, rice, spinach, kale, and dairy products.
The human body is capable of producing lipoic acid on its own. But even taking into account the amount that can be obtained from food, the level of its content will not be sufficient for the healthy functioning of the body. Therefore, doctors advise to pay attention to the addition of alpha-lipoic acid in the form of a supplement.It is available in several forms: in the form of capsules, powder and ampoules for intravenous injection.
Natural sources CLA
- Grass-fed beef – 433 mg per serving
- Cheese from grass-fed cows – 180-270 mg
- Whole milk from grass-fed cows – 160-240 mg
- Lamb – 148 mg
- Whole milk – 44 mg
- Plain yogurt – 43 mg
- Butter – 54 mg
- Curd – 22 mg
- 2% milk – 20 mg
How to take it right?
Like other vitamin-like substances, lipoic acid has its own consumption rates.They will be different depending on the age. Children under the age of 15 are advised to take 12-25 mg per day, in adults – about 25-50 mg. During periods of intense physical or emotional stress, it is worth increasing the intake of lipoic acid to 75 mg. If lipoic acid is included in the program of complex treatment of any disease, then its dosages can be significantly increased.
It should be noted that at the time of taking lipoic acid, it is necessary to stop drinking alcohol.
Lipoic acid should not be used by children under 6 years of age and people with hypersensitivity to the drug. Care must be taken when taking it during pregnancy or lactation. In the latter case, it is better to consult a specialist.
In the study of the effect of lipoic acid on the human body, no significant negative consequences were revealed. Even when combined with other antioxidants: vitamins A or C, L-carnitine or green tea extract.However, if the recommended dosages are exceeded excessively, side effects may occur. Always check with your doctor before taking any supplement.
Alpha Lipoic Acid is a versatile antioxidant that fights antioxidants and slows down the aging process. It enhances the action of many vitamins, helping to strengthen the immune system and improve overall health, and regulates metabolism. For athletes, it can be of particular interest, as it helps to maintain muscle mass while losing weight and increase physical performance.It also prevents protein breakdown. Taking alpha lipoic acid will not only help to replenish the lack of a substance in the body, but also affect the effectiveness of training.
Articles on our site are presented for educational and informational purposes only. We do not recommend using the materials of the articles as medical advice. If you decide to take supplements or make major changes to your diet, consult with a specialist first.