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Side effects of acetaminophen pm. Acetaminophen PM: Understanding the Uses, Side Effects, and Warnings

What are the uses of acetaminophen PM? What are the side effects to be aware of? Get a thorough understanding of the warnings and dosage instructions for this medication.

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Understanding Acetaminophen PM

Acetaminophen PM is a combination medication that contains two active ingredients: acetaminophen and an antihistamine. This formulation is designed to provide relief for various ailments, including fever, mild to moderate pain, and allergy or cold symptoms.

Uses of Acetaminophen PM

Acetaminophen, the primary component of Acetaminophen PM, is an effective pain reliever and fever reducer. It can be used to alleviate headaches, backaches, muscle aches, and discomfort associated with colds or flu. The antihistamine in this product can help reduce symptoms such as watery eyes, itchy eyes/nose/throat, runny nose, and sneezing, making it useful for allergy or cold relief.

Acetaminophen PM can also be used as a nighttime sleep aid due to the sedative effects of the antihistamine. However, it is important to note that cough-and-cold products, including Acetaminophen PM, have not been shown to be safe or effective for use in children younger than 6 years old. Consult with a healthcare professional before administering this medication to young children.

Warnings and Precautions

One of the key warnings associated with Acetaminophen PM is the potential for liver damage if too much acetaminophen is consumed. Adults should not take more than 4,000 milligrams (4 grams) of acetaminophen per day, and people with liver problems and children should take even less. It is crucial to ask your doctor or pharmacist about the safe dosage for your specific situation.

Another important warning is to avoid using Acetaminophen PM with any other medication containing acetaminophen, as this can lead to an accidental overdose. Acetaminophen is present in many over-the-counter and prescription medications, so it is essential to check the labels of all your medications and consult with a healthcare professional if you are unsure.

If you accidentally take too much acetaminophen, even if you feel well, seek medical help immediately. Overdose symptoms may include nausea, vomiting, loss of appetite, sweating, abdominal pain, extreme tiredness, yellowing of the eyes or skin, and dark urine.

Additionally, it is important to avoid consuming alcohol while taking Acetaminophen PM, as the combination can significantly increase the risk of liver damage.

Dosage and Administration

When taking Acetaminophen PM, follow the instructions on the product package or those provided by your healthcare provider. If you are using the over-the-counter formulation, read the directions carefully and consult a pharmacist if you have any questions.

For the oral tablet or liquid formulations, take the medication by mouth with or without food. If you are using the extended-release capsules, swallow them whole and do not crush or chew them. The dosage may be adjusted based on your medical condition and response to the medication.

Potential Side Effects

While Acetaminophen PM is generally well-tolerated, there are some potential side effects to be aware of. Common side effects may include drowsiness, dizziness, and nausea. If you experience any severe or persistent side effects, contact your healthcare provider immediately.

Key Takeaways

  • Acetaminophen PM is a combination medication that provides relief for fever, pain, and allergy or cold symptoms.
  • The primary warning is the risk of liver damage from excessive acetaminophen consumption, so it is crucial to follow the recommended dosage guidelines.
  • Avoid using Acetaminophen PM with other medications containing acetaminophen, and do not consume alcohol while taking this medication.
  • Follow the dosage instructions carefully, and seek immediate medical attention if you suspect an overdose or experience severe side effects.

Remember, it is always important to consult with a healthcare professional before starting any new medication or making changes to your existing treatment plan. They can provide personalized guidance on the safe and effective use of Acetaminophen PM.

Acetaminophen PM Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Warnings:

One ingredient in this product is acetaminophen. Taking too much acetaminophen may cause serious (possibly fatal) liver disease. Adults should not take more than 4000 milligrams (4 grams) of acetaminophen a day. People with liver problems and children should take less acetaminophen. Ask your doctor or pharmacist how much acetaminophen is safe to take.

Do not use with any other drug containing acetaminophen without asking your doctor or pharmacist first. Acetaminophen is in many nonprescription and prescription medications (such as pain/fever drugs or cough-and-cold products). Check the labels on all your medicines to see if they contain acetaminophen, and ask your pharmacist if you are unsure.

Get medical help right away if you take too much acetaminophen (overdose), even if you feel well. Overdose symptoms may include nausea, vomiting, loss of appetite, sweating, stomach/abdominal pain, extreme tiredness, yellowing eyes/skin, and dark urine.

Daily alcohol use, especially when combined with acetaminophen, may damage your liver. Avoid alcohol.

Warnings:

One ingredient in this product is acetaminophen. Taking too much acetaminophen may cause serious (possibly fatal) liver disease. Adults should not take more than 4000 milligrams (4 grams) of acetaminophen a day. People with liver problems and children should take less acetaminophen. Ask your doctor or pharmacist how much acetaminophen is safe to take.

Do not use with any other drug containing acetaminophen without asking your doctor or pharmacist first. Acetaminophen is in many nonprescription and prescription medications (such as pain/fever drugs or cough-and-cold products). Check the labels on all your medicines to see if they contain acetaminophen, and ask your pharmacist if you are unsure.

Get medical help right away if you take too much acetaminophen (overdose), even if you feel well. Overdose symptoms may include nausea, vomiting, loss of appetite, sweating, stomach/abdominal pain, extreme tiredness, yellowing eyes/skin, and dark urine.

Daily alcohol use, especially when combined with acetaminophen, may damage your liver. Avoid alcohol.

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Uses

This combination product contains 2 medications, acetaminophen and an antihistamine. Acetaminophen helps to reduce fever and/or mild to moderate pain (such as headache, backache, aches/pains due to muscle strain, cold, or flu). The antihistamine in this product may cause drowsiness, so it can also be used as a nighttime sleep aid. Antihistamines can also be used to help relieve allergy or cold symptoms such as watery eyes, itchy eyes/nose/throat, runny nose, and sneezing.Cough-and-cold products have not been shown to be safe or effective in children younger than 6 years. Do not use this product to treat cold symptoms in children younger than 6 years unless specifically directed by the doctor. Some products (such as long-acting tablets/capsules) are not recommended for use in children younger than 12 years. Ask your doctor or pharmacist for more details about using your product safely. These products do not cure or shorten the length of the common cold and may cause serious side effects. To decrease the risk for serious side effects, carefully follow all dosage directions. Do not use this product to make a child sleepy. Do not give other cough-and-cold medication that might contain the same or similar ingredients (see also Drug Interactions section). Ask the doctor or pharmacist about other ways to relieve cough and cold symptoms (such as drinking enough fluids, using a humidifier or saline nose drops/spray).

How to use Acetaminophen PM

See also Warning section.

If you are taking an over-the-counter product, read all directions on the product package before taking this medication. If you have any questions, consult your pharmacist. If your doctor has prescribed this medication, take it as directed.

Take this medication by mouth with or without food or as directed by your doctor. If stomach upset occurs, you may take this medication with food or milk.

If you are using the liquid form, carefully measure your prescribed dose using a medication-measuring device or spoon. Do not use a household spoon because you may not get the correct dose.

If you are taking extended-release capsules, swallow them whole. Do not crush or chew extended-release capsules or tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split extended-release tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.

The dosage is based on your medical condition and response to treatment. Pain medications work best if they are used as the first signs of pain occur. If you wait until the symptoms have worsened, the medication may not work as well.

Do not take this product for pain more than 10 days (adults) or 5 days (children) unless directed by a doctor. Do not take this product for fever more than 3 days unless directed by your doctor. If your condition lasts or gets worse, or if you think you may have a serious medical problem, get medical help right away.

Side Effects

See also Warning section.

Dizziness, drowsiness, constipation, stomach upset, blurred vision, or dry mouth/nose/throat may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

If your doctor has prescribed this medication, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: mental/mood changes (such as confusion), trouble urinating.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

See also Warning section.

Before taking this medication, tell your doctor or pharmacist if you are allergic to acetaminophen or antihistamines; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: breathing problems (such as asthma, chronic obstructive pulmonary disease-COPD), glaucoma, heart disease, high blood pressure, liver disease, stomach/intestinal problems (such as blockage, constipation, ulcers), overactive thyroid gland (hyperthyroidism), urination problems (such as trouble urinating due to enlarged prostate, urinary retention).

This drug may make you dizzy or drowsy or blur your vision. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

Liquid products may contain alcohol, sugar, and/or aspartame. Caution is advised if you have diabetes, alcohol dependence, liver disease, phenylketonuria (PKU), or any other condition that requires you to limit/avoid these substances in your diet. Ask your doctor or pharmacist about using this product safely.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Children may be more sensitive to the side effects of antihistamines. In young children, this drug may cause agitation and excitement instead of drowsiness.

Older adults may be more sensitive to the side effects of this drug, especially dizziness, drowsiness, confusion, constipation, or trouble urinating. Dizziness, drowsiness, and confusion can increase the risk of falling.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

This drug may pass into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.

Interactions

See also Warning section.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Some products that may interact with this drug are: antihistamines applied to the skin (such as diphenhydramine cream, ointment, spray), ketoconazole, levoketoconazole.

Tell your doctor or pharmacist if you are taking other products that cause drowsiness such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or other antihistamines (such as cetirizine, diphenhydramine).

Antihistamines are ingredients found in many nonprescription products and in some combination prescription medications. Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may also contain an antihistamine or other ingredients that cause drowsiness. Ask your pharmacist about using those products safely.

This medication may interfere with certain medical/laboratory tests (such as urine 5-HIAA, allergy skin tests), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Does Acetaminophen PM interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: nausea, vomiting, loss of appetite, sweating, stomach/abdominal pain, extreme tiredness, agitation, confusion, flushing, hallucinations, yellowing eyes/skin, dark urine, seizures. In children, excitement may occur first, and may be followed by: loss of coordination, drowsiness, loss of consciousness, seizures.

If your doctor has prescribed this medication, do not share it with others.

Keep all medical and lab appointments.

If you are taking this product on a regular schedule and miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature away from light and moisture. Do not store in the bathroom. Do not freeze liquid forms of this product. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Images

Acetaminophen PM 25 mg-500 mg tablet

Color: blueShape: oblongImprint: 44 235

This medicine is a blue, oblong, film-coated, tablet imprinted with “44 235”.

Acetaminophen PM 25 mg-500 mg tablet

Color: white,blueShape: roundImprint: BP50 or plain BP50 or plain

This medicine is a blue, oblong, film-coated, tablet imprinted with “44 235”.

Acetaminophen PM 25 mg-500 mg tablet

Color: blueShape: ovalImprint: AAA 1031

This medicine is a blue, oblong, film-coated, tablet imprinted with “44 235”.

Acetaminophen PM 25 mg-500 mg tablet

Color: dark blue,light blueShape: oblongImprint: L 6

This medicine is a blue, oblong, film-coated, tablet imprinted with “44 235”.

Acetaminophen PM 25 mg-500 mg tablet

Color: white,blueShape: roundImprint: L837

This medicine is a blue, oblong, film-coated, tablet imprinted with “44 235”.

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Tylenol PM (Acetaminophen And Diphenhydramine)

uses

What is Tylenol PM (Acetaminophen And Diphenhydramine) used for?

  • Insomnia
  • Migraine
  • Pain
  • Headache

warnings

What is the most important information I should know about Tylenol PM (Acetaminophen And Diphenhydramine)?

Ask a doctor before taking medicine that contains acetaminophen if you have ever had liver disease, or if you drink more than 3 alcoholic beverages per day.

Ask a doctor or pharmacist if this medicine is safe to use if you have ever had:

  • liver disease;
  • an enlarged prostate or urination problems;
  • asthma, chronic obstructive pulmonary disease (COPD), emphysema, or other breathing disorder;
  • glaucoma; or
  • a condition for which you take warfarin (Coumadin, Jantoven).

Ask a doctor before using this medicine if you are pregnant or breastfeeding. Diphenhydramine may slow breast milk production.

Side Effects

What are the side effects of Tylenol PM (Acetaminophen And Diphenhydramine)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

In rare cases, acetaminophen may cause a severe skin reaction that can be fatal. This could occur even if you have taken acetaminophen in the past and had no reaction. Stop taking this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling. If you have this type of reaction, you should never again take any medicine that contains acetaminophen.

Stop using the medicine and call your doctor at once if you have:

  • severe drowsiness;
  • painful or difficult urination; or
  • liver problems–loss of appetite, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects may include:

  • drowsiness;
  • constipation;
  • decreased urination;
  • dry eyes, blurred vision; or
  • dry mouth, nose, or throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Pregnancy & Breastfeeding

Can I take Tylenol PM (Acetaminophen And Diphenhydramine) if I’m pregnant or breastfeeding?

Ask a doctor before using this medicine if you are pregnant or breastfeeding. Diphenhydramine may slow breast milk production.

Interactions

What drugs and food should I avoid while taking Tylenol PM (Acetaminophen And Diphenhydramine)?

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

Ask a doctor or pharmacist before using any other medicine that may contain acetaminophen or diphenhydramine. This includes medicines for pain, fever, swelling, cold/flu symptoms, or anti-itch medicine used on the skin. Using too much acetaminophen or diphenhydramine can lead to a fatal overdose.

Drinking alcohol may increase your risk of liver damage while taking acetaminophen.

Dosage Guidelines & Tips

How to take Tylenol PM (Acetaminophen And Diphenhydramine)?

Use Tylenol PM (Acetaminophen And Diphenhydramine) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

What should I do if I missed a dose of Tylenol PM (Acetaminophen And Diphenhydramine)?

Since acetaminophen and diphenhydramine is used when needed, you may not be on a dosing schedule. Skip any missed dose if it’s almost time for your next dose. Do not use two doses at one time.

Overdose Signs

What happens if I overdose on Tylenol PM (Acetaminophen And Diphenhydramine)?

Overdose symptoms may include loss of appetite, vomiting, weakness, confusion, ringing in your ears, upper stomach pain, dark urine, no urination, very dry eyes and mouth, yellowing of your skin or eyes, dilated pupils, fast heartbeats, tremor, agitation, hallucinations, or seizure.

If you think you or someone else may have overdosed on: Tylenol PM (Acetaminophen And Diphenhydramine),  call your doctor or the Poison Control center

(800) 222-1222

If someone collapses or isn’t breathing after taking Tylenol PM (Acetaminophen And Diphenhydramine), call 911

911

Acetaminophen, Aspirin, and Caffeine | Memorial Sloan Kettering Cancer Center

Adult Medication

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Provided by Lexicomp ® , this document contains all the information you need to know about this medicine, including indications, directions for use, side effects, and when your healthcare provider should be contacted.

Trade names: USA

Excedrin Extra Strength [OTC]; Excedrin Migraine [OTC]; GoodSense Headache Relief [OTC] GoodSense Migraine Formula [OTC]; Pain Reliever Extra Strength [OTC]; Pain Reliever Plus [OTC]; Pain Off [OTC]

What is this drug used for?

  • Used to treat migraine.
  • Used to relieve pain.
  • This drug may also be used for other indications. Consult your doctor.

What should I tell my doctor BEFORE taking this drug?

For all patients taking this drug:
  • If you have an allergy to this drug, any of its ingredients, other drugs, foods or substances. Tell your doctor about your allergies and how they have manifested.
  • If you have had nasal polyps or inflammation in your mouth, face, lips, tongue, or throat, unusual hoarseness, or difficulty breathing while taking aspirin or NSAIDs.
  • If you have liver disease.
  • If you are bleeding.
  • If you are taking another drug that contains the same medicine.
  • If you are taking other non-steroidal anti-inflammatory drugs (NSAIDs).
  • If you are pregnant, plan to become pregnant, or become pregnant while taking this drug. If you take this drug after 20 weeks of pregnancy, it may harm the fetus. If you are 20 to 30 weeks pregnant, take this drug only as directed by your doctor. Do not use this drug after 30 weeks of pregnancy.
Children:
  • If your toddler or teen has symptoms of the flu, chickenpox or other viral infections, or is recovering. The risk of developing a very serious condition called Reye’s syndrome may be increased. Do not give this drug to a child or teenager who has or is recovering from a viral infection.

This list of drugs and conditions that may interact with this drug is not exhaustive.

Tell your doctor and pharmacist about all medicines you take (both prescription and over-the-counter, natural products and vitamins) and any health problems you have. You need to make sure that this drug is safe for your conditions and in combination with other drugs you are already taking. Do not start or stop taking any drug or change the dosage without your doctor’s advice.

What do I need to know or do while taking this drug?

  • Tell all your health care workers that you are taking this drug. These are doctors, nurses, pharmacists and dentists.
  • Do not take the drug in higher doses than prescribed by your doctor. Taking more than the prescribed amount of the drug increases the risk of serious side effects.
  • Do not take this drug for longer than the length of time your doctor has prescribed.
  • If you are allergic to tartrazine (dye yellow #5), talk to your doctor. Some products contain tartrazine.
  • It is not recommended to use other medicines containing acetaminophen. Carefully study the instructions for medicines. Taking acetaminophen in excessive amounts can lead to liver problems.
  • This medicine contains acetaminophen. During the use of acetaminophen, liver disorders were recorded. In some cases, these disorders have required liver transplantation or have resulted in death. The majority of liver problems occurred in patients taking more than 4,000 milligrams (mg) of acetaminophen per day. Often, patients used not 1, but several drugs containing acetaminophen.
  • Follow the instructions exactly. Do not exceed your daily dose of acetaminophen. If you are not sure what your daily dose of acetaminophen is, ask your doctor or pharmacist for it. Some people may take this drug in doses up to 4,000 milligrams (mg) per day as directed by their doctor. Some patients (eg, those with liver disease and children) require a dose reduction of acetaminophen. If you have exceeded your daily dose of acetaminophen, contact your doctor immediately, even if you do not feel worse.
  • Consult your doctor before drinking alcohol.
  • If you smoke, please consult your doctor.
  • There is an increased chance of bleeding. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
  • Be careful if you have low levels of an enzyme called glucose-6-phosphate dehydrogenase (G6PD). Anemia may occur. Low levels of G6PD are more common in patients of African, South Asian, Middle Eastern, and Mediterranean origin.
  • Limit caffeine (such as tea, coffee, and cola) and chocolate. When taken with this drug, it can cause nervousness, tremors, and tachycardia.
  • If you are taking aspirin to prevent myocardial infarction, talk to your doctor.
  • This drug may affect the results of some lab tests. Tell all your health care workers and laboratory staff that you are taking this drug.
  • If you are 60 years of age or older, take this drug with caution. You may experience more side effects.
  • Tell your doctor if you are breastfeeding. It is necessary to consult whether the drug poses any risk to the child.

What side effects should I report to my doctor immediately?

WARNING. In rare cases, this drug can cause serious and sometimes deadly side effects in some patients. Call your doctor right away or get medical help if you have any of the following signs or symptoms that could be associated with serious side effects:

  • Signs of an allergic reaction, such as rash, hives, itching, red and swollen skin with blisters or peeling, possibly accompanied by fever, wheezing or wheezing, tightness in the chest or throat, difficulty breathing, swallowing or speaking, unusual hoarseness, swelling in the mouth, face, lips, tongue or throat.
  • Signs of liver problems such as dark urine, fatigue, lack of appetite, nausea or abdominal pain, light-colored stools, vomiting, yellowing of the skin or eyes.
  • signs of bleeding, such as vomiting or coughing up blood; vomiting of the type of coffee grounds; blood in the urine; black, red, or tarry stools; bleeding from the gums; non-cyclic vaginal bleeding; bruises that appear or increase for no reason; bleeding that you cannot stop.
  • Confusion of consciousness.
  • Movement disorders.
  • Feeling extremely tired or weak.
  • Severe dizziness or fainting.
  • Ringing in the ears, hearing loss, or any other hearing changes.
  • Possible severe skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis). This can lead to severe health problems, which can be permanent, and sometimes death. Seek immediate medical attention if you experience symptoms such as redness, swelling of the skin with blistering or peeling (with or without fever), redness or irritation of the eyes, and sores in the mouth, throat, nose, or eyes.
  • Very bad stomach ulcers or very heavy bleeding may occur with this drug. Taking the drug in high doses or for a long time, smoking or drinking alcohol increases the risk of these side effects. Taking this drug with food does not reduce the risk of these effects. If you have very severe pain in your abdomen or back, black, tarry or bloody stools, vomit that looks like blood or coffee grounds, weight gain, or unusual inflammation, call your doctor or get medical help right away.

What are some other side effects of this drug?

Any medicine can have side effects. However, for many people, side effects are either minor or non-existent. Contact your doctor or seek medical attention if these or any other side effects bother you or do not go away:

  • Abdominal pain or heartburn.
  • Nausea.

This list of possible side effects is not exhaustive. If you have any questions about side effects, please contact your doctor. Talk to your doctor about side effects.

You can report side effects to the National Health Board.

You can report side effects to the FDA at 1-800-332-1088. You can also report side effects at https://www.fda.gov/medwatch.

What is the best way to take this drug?

Use this drug as directed by your doctor. Read all the information provided to you. Strictly follow all instructions.

All forms:
  • Take with or without food. Take with food if medicine causes nausea.
Tablets:
  • Take this drug with a full glass of water.
Powder:
  • Put the powder on your tongue and drink with a full glass of water or other liquid. You can also mix the powder with water and drink.

What if I miss a dose of a drug?

  • This drug should be taken as needed. Do not take the drug more often than prescribed by your doctor.

How do I store and/or discard this drug?

  • Store at room temperature in a dry place. Do not store in the bathroom.
  • Keep all medicines in a safe place. Keep all medicines out of the reach of children and pets.
  • Dispose of unused or expired drugs. Do not empty into a toilet or sewer unless instructed to do so. If you have any questions about disposing of medicines, ask your pharmacist. Drug disposal programs may be in place in your area.

General information about medicines

  • If your health does not improve or even worsens, see your doctor.
  • Do not give your medicine to anyone and do not take other people’s medicines.
  • Some medicines may come with other patient information leaflets. If you have questions about this drug, talk with your doctor, nurse, pharmacist, or other health care professional.
  • Some medicines may come with other patient information leaflets. Check with your pharmacist. If you have questions about this drug, talk with your doctor, nurse, pharmacist, or other health care professional.
  • If you think you have overdosed, call a poison control center or get medical help right away. Be prepared to tell or show what drug you took, how much, and when it happened.

Consumer Use of Information and Limitation of Liability

This summary information includes a summary of the diagnosis, treatment, and/or drug product. It is not intended to be a comprehensive source of data and should be used as a tool to help the user understand and/or evaluate potential diagnostic and treatment options. It does NOT include all information about conditions, treatments, medications, side effects, or risks that may apply to a particular patient. It should not be considered medical advice or a substitute for medical advice, diagnosis or treatment provided by a physician based on a medical examination and assessment of the patient’s specific and unique circumstances. Patients should consult with their physician for full information about their health, medical issues, and treatment options, including any risks or benefits regarding the use of medications. This information is not a guarantee that a treatment or drug is safe, effective, or approved for a particular patient. UpToDate, Inc. and its subsidiaries disclaim any warranties or liabilities related to this information or its use. The use of this information is subject to the Terms of Use found at https://www.wolterskluwer.com/en/know/clinical-effectiveness-terms.

Last revision date

2023-02-07

Copyright

© UpToDate, Inc. and its affiliates and/or licensors, 2023. All rights reserved.

Date last updated

Monday, December 12, 2022

Acetaminophen (paracetamol) analysis, drug monitoring in St. Petersburg

Biomaterial and collection method

Type Center Home Self
Venous blood

Deadline: 2 – 5 days.

Synonyms (eng)

Paracetamol, Acetaminophen, Ifimol.

Download sample analysis

Paracetamol (acetaminophen) belongs to the group of antipyretic analgesics, i.e. has a pronounced analgesic and antipyretic effect. The mechanism of action of this drug is the ability to non-selectively block the enzyme cyclooxygenase 1 and 2 (COX1 and COX2) in the pain centers and thermoregulation centers of the brain, which leads to a decrease in the synthesis of prostaglandins and the development of the desired effect. In peripheral tissues, cellular peroxidases block the effect of the drug on COX, which explains the almost complete absence of an anti-inflammatory effect.

Paracetamol is generally well tolerated and rarely causes any side effects. Especially carefully should be used the drug in childhood. If the therapeutic dose is exceeded, the development of toxic effects of acetaminophen on the human body is possible. The most common toxic damage to the liver in the form of liver failure, in severe cases, the development of hepatic encephalopathy and coma is possible. It should be noted that the toxic effect is enhanced by the combined use of paracetamol and sleeping pills, alcohol. Also, in case of an overdose, damage to the red bone marrow is possible with the development of agranulocytosis, anemia, and thrombocytopenia. Toxic damage to the kidneys manifests itself in the form of glomerulonephritis, aseptic pyuria, renal colic, renal failure. If the heart muscle is damaged, patients may develop hypertension, myocardial infarction, and arrhythmias. With the joint use of paracetamol and NSAIDs, the toxic effect of the drug on the kidneys increases. Paracetamol increases the effect of indirect anticoagulants (warfarin), which is accompanied by an increase in INR. The likelihood of liver damage from hepatotoxic drugs is also increased during treatment with acetaminophen.

Drug monitoring of paracetamol is carried out with the development of symptoms of an overdose of the drug. This study makes it possible to determine the concentration of acetaminophen in the blood, to establish the toxic level of the drug, to evaluate its interaction with drugs from other groups.

  • do not eat fatty foods a few hours before the test, preferably not eat for 4 hours;
  • shortly before taking blood, drink 1-2 glasses of ordinary non-carbonated water;
  • do not play sports on the day of the test;
  • exclude increased emotional stress;
  • a few minutes before taking blood, take a comfortable position (sit down), relax, calm down;
  • do not smoke for at least 30 min. before taking blood;
  • refrain from drinking alcohol for 72 hours before taking the test;
Test code Test name Unit Reference
14-266 Allergen – paracetamol, IgE IU/ml 0-0.

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