What are the potential benefits of Alpha Lipoic Acid supplements. How does ALA affect diabetes and neuropathy. What are the possible side effects of taking ALA. Is ALA safe for long-term use. How does ALA function as an antioxidant in the body. Can ALA supplements aid in weight loss. What is the recommended dosage for ALA supplements.

Understanding Alpha Lipoic Acid: Nature’s Powerful Antioxidant

Alpha Lipoic Acid (ALA) is a naturally occurring compound produced within the human body. This remarkable substance plays a crucial role in cellular energy production and serves as a potent antioxidant. While the body typically generates sufficient ALA for its basic needs, there has been growing interest in ALA supplementation for various health benefits.

ALA’s antioxidant properties make it a subject of interest for researchers and health enthusiasts alike. But what exactly does this mean for our health?

The Antioxidant Power of ALA

As an antioxidant, ALA helps protect our cells from damage caused by free radicals. These unstable molecules can harm cellular structures, contributing to aging and various diseases. ALA’s unique ability to function in both water-soluble and fat-soluble environments within the body sets it apart from other antioxidants, potentially making it more versatile in its protective effects.

Natural Sources of ALA

While ALA supplements are available, this compound can also be found in several food sources, including:

• Organ meats (liver and heart)
• Yeast
• Spinach
• Broccoli
• Potatoes

However, it’s important to note that dietary ALA doesn’t significantly increase free ALA levels in the body. This is one reason why some individuals turn to supplements to boost their ALA intake.

ALA and Diabetes Management: A Promising Connection

One of the most extensively studied areas of ALA supplementation is its potential benefits for individuals with type 2 diabetes. Research has shown promising results in two key areas:

Improving Insulin Sensitivity

Some studies suggest that ALA supplements may enhance the body’s ability to utilize its own insulin more effectively, potentially leading to better blood sugar control in people with type 2 diabetes. This improved insulin sensitivity could be a valuable tool in managing the condition.

Alleviating Diabetic Neuropathy Symptoms

Diabetic neuropathy, a common complication of diabetes characterized by nerve damage, has been a focus of ALA research. In Europe, ALA has been used for years to provide relief from the symptoms associated with this condition, including:

• Pain
• Burning sensations
• Tingling
• Numbness

A large study demonstrated significant symptom relief with high intravenous doses of ALA. However, the evidence for oral ALA supplements in treating diabetic neuropathy is less conclusive, warranting further research.

Exploring ALA’s Potential in Other Health Conditions

While diabetes management has been at the forefront of ALA research, scientists are exploring its potential benefits in various other health conditions. Some areas of interest include:

HIV Management

Preliminary research suggests that ALA may have some beneficial effects for individuals living with HIV. However, more comprehensive studies are needed to establish its efficacy and safety in this context.

Liver Health

Some studies have investigated ALA’s potential role in supporting liver function and protecting against liver damage. While initial results are promising, further research is required to fully understand its effects on liver health.

Weight Loss

Recent interest has emerged in ALA’s potential as a weight loss aid. However, current evidence in humans is limited, and more research is needed to determine if ALA supplementation can indeed contribute to weight management efforts.

ALA Supplementation: Safety Considerations and Side Effects

As with any supplement, it’s crucial to consider the potential risks and side effects of ALA supplementation. While ALA is generally considered safe for most people, there are some important factors to keep in mind:

Reported Side Effects

Side effects from ALA supplements appear to be rare and generally mild. The most commonly reported side effect is a skin rash. However, it’s important to note that research on long-term use of ALA supplements is limited, and potential effects of prolonged high-dose supplementation are not well understood.

Interactions with Medications

Individuals taking medications to lower blood sugar, such as insulin or oral diabetes drugs, should exercise caution when considering ALA supplements. ALA may enhance the effect of these medications, potentially leading to hypoglycemia (low blood sugar). It’s crucial to consult with a healthcare provider before starting ALA supplementation, especially if you’re managing diabetes or taking blood sugar-lowering medications.

Pregnancy and Children

Due to the lack of studies on ALA use during pregnancy, it is not recommended for pregnant women. Similarly, there is insufficient data on its use in children, so ALA supplements should not be given to pediatric populations without medical supervision.

Optimizing ALA Absorption and Dosage

For those considering ALA supplementation, understanding how to maximize its absorption and determine appropriate dosage is essential:

Absorption Rates

Studies indicate that approximately 30% to 40% of an oral ALA supplement dose is absorbed by the body. To potentially improve absorption, it’s suggested that ALA supplements be taken on an empty stomach.

Dosage Considerations

Currently, there are no standardized dosage recommendations for ALA supplements. The optimal dose may vary depending on the intended use and individual factors. In studies focusing on diabetic neuropathy, doses ranging from 600 to 1800 mg daily have been used. However, it’s crucial to consult with a healthcare provider to determine the most appropriate dosage for your specific needs.

The Future of ALA Research: Promising Avenues and Unanswered Questions

As interest in ALA supplementation continues to grow, researchers are exploring its potential in various areas of health and wellness. Some promising avenues for future research include:

Neurodegenerative Diseases

Preliminary studies suggest that ALA’s antioxidant properties may have neuroprotective effects, potentially benefiting conditions such as Alzheimer’s and Parkinson’s disease. Further research is needed to fully understand its role in brain health and cognitive function.

Cardiovascular Health

Some studies have investigated ALA’s potential to improve cardiovascular risk factors, such as blood pressure and lipid profiles. While initial results are promising, more comprehensive research is required to establish its efficacy in this area.

Metabolic Syndrome

Given its potential effects on insulin sensitivity and weight management, researchers are exploring ALA’s role in addressing metabolic syndrome, a cluster of conditions that increase the risk of heart disease, stroke, and type 2 diabetes.

Integrating ALA into a Holistic Health Approach

While ALA supplementation shows promise in various areas of health, it’s important to view it as part of a comprehensive approach to wellness. Consider the following strategies to maximize the potential benefits of ALA:

Balanced Diet

Incorporating ALA-rich foods into your diet can provide natural sources of this compound. Focus on consuming a variety of nutrient-dense foods, including leafy greens, organ meats, and cruciferous vegetables.

Regular Exercise

Physical activity complements the potential benefits of ALA, particularly in areas such as blood sugar control and weight management. Aim for a combination of aerobic exercise and strength training for optimal results.

Stress Management

Chronic stress can negatively impact overall health and potentially counteract the benefits of antioxidants like ALA. Incorporate stress-reduction techniques such as meditation, yoga, or deep breathing exercises into your daily routine.

Regular Health Check-ups

If you’re considering ALA supplementation, particularly for managing a specific health condition, regular consultations with your healthcare provider are essential. They can monitor your progress, adjust dosages if necessary, and ensure that ALA supplementation aligns with your overall health goals.

As research on Alpha Lipoic Acid continues to evolve, it’s clear that this powerful antioxidant holds significant potential in various aspects of health and wellness. While current evidence is promising, particularly in the areas of diabetes management and neuropathy relief, more comprehensive studies are needed to fully understand its long-term effects and optimal usage. As with any supplement, it’s crucial to approach ALA supplementation with caution and under the guidance of a healthcare professional. By integrating ALA into a holistic health strategy that includes a balanced diet, regular exercise, and stress management, individuals may be able to harness its potential benefits while supporting overall well-being.

Alpha Lipoic Acid (ALA) Supplement Benefit, Side Effects

Written by Joseph Saling

In this Article

• ALA, the Antioxidant
• ALA and Diabetes
• ALA and Other Health Conditions
• Side Effects and Precautions of ALA Supplement

Alpha-lipoic acid or ALA is a naturally occurring compound that’s made in the body. It serves vital functions at the cellular level, such as energy production. As long as you’re healthy, the body can produce all the ALA it needs for these purposes. Despite that fact, there has been a lot of recent interest in using ALA supplements. Advocates of ALA make claims that range from beneficial effects for treating conditions such as diabetes and HIV to enhancing weight loss.

Research on the effects of ALA supplementation is sparse. What there is, though, does suggest some possible benefits. Here is what’s known about the potential health benefits of using alpha-lipoic acid supplements.

ALA is an antioxidant. Antioxidants protect against damage to the body’s cells.

There are food sources of ALA such as yeast, organ meats like liver and heart, spinach, broccoli, and potatoes. However, ALA from food does not appear to produce a noticeable increase in the level of free ALA in the body.

Some people take ALA supplements with the intent to improve a variety of health conditions. Scientific evidence for the health benefit of supplemental ALA has been inconclusive.

Studies show that about 30% to 40% of the oral dose of an ALA supplement is absorbed. ALA may be better absorbed if it is taken on an empty stomach.

While studies are still sparse, there is some evidence that ALA may have at least two positive benefits for individuals with type 2 diabetes. A few studies have suggested that alpha-lipoic acid supplements may enhance the body’s ability to use its own insulin to lower blood sugar in people with type 2 diabetes. ALA may help reduce the symptoms of peripheral neuropathy — nerve damage that can be caused by diabetes.

In Europe, ALA has been used for years to provide relief from the pain, burning, tingling, and numbing caused by diabetic neuropathy. In particular, one large study strongly suggested that large intravenous doses of ALA were effective at relieving symptoms. But the evidence for oral doses is not as strong. More research is needed to establish the effectiveness of oral ALA supplements for diabetic neuropathy.

ALA has been suggested as a potential aid in stopping or slowing the damage done by a variety of other health conditions from HIV to liver disease. However, much of the research is still early and evidence isn’t conclusive.

There has also been recent interest in supplemental ALA for weight loss. But again, there is no evidence that ALA has any effect on weight loss in humans, and more research needs to be done.

Side effects from using ALA supplements appear to be rare and mild, such as skin rash. However, little is known about the possible effect of long-term use of ALA supplements. And there are no dosage recommendations and little data on the potential effect of large doses taken over time.

ALA should not be used without a recommendation from your doctor if you take insulin or other medications to lower blood sugar. It’s possible that it can enhance the effect of these drugs, leading to hypoglycemia (low blood sugar). Discuss the use of supplemental ALA with your doctor first. Your doctor may recommend that you increase monitoring of blood sugar levels. The doctor may also want to make an adjustment in your medication.

Because no studies have been done on the effect of using ALA during pregnancy, you should not use it if pregnant. Also, there are no data about its use by children, so children should not take ALA supplements.

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Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Alpha-lipoic acid is an antioxidant that is made naturally in the body and also found in foods. It is used to break down carbohydrates and to make energy.

Alpha-lipoic acid can be eaten in foods, such as red meat, carrots, beets, spinach, broccoli, and potatoes. It is also available in supplements. Because alpha-lipoic acid seems to work like an antioxidant, it might provide protection to the brain and also be helpful in certain liver diseases.

People most commonly use alpha-lipoic acid for nerve pain in people with diabetes. It is also used for obesity, altitude sickness, aging skin, high levels of cholesterol or other fats in the blood, and many other purposes, but there is no good scientific evidence to support many of these other uses.

Uses & Effectiveness ?

Possibly Effective for

• Nerve pain in people with diabetes (diabetic neuropathy). Taking 600-1800 mg of alpha-lipoic acid by mouth or by IV seems to improve symptoms such as burning, pain, and numbness in the legs and arms of people with diabetes. Lower doses of alpha-lipoic acid don’t seem to work. IV products can only be given by a healthcare provider.
• High levels of cholesterol or other fats (lipids) in the blood (hyperlipidemia). Taking alpha-lipoic acid by mouth for up to 4 years seems to lower total cholesterol and low-density lipoprotein (LDL or “bad”) cholesterol in people with or without hyperlipidemia.
• Obesity. Taking alpha-lipoic acid by mouth can slightly reduce body weight in adults who are overweight.

Possibly Ineffective for

• Liver disease in people who drink alcohol. Taking alpha-lipoic acid by mouth daily for up to 6 months does not improve liver function or reduce liver damage in people with alcohol-related liver disease.
• Altitude sickness. Taking alpha-lipoic acid by mouth along with vitamin C and vitamin E does not seem to prevent altitude sickness.
• Kidney damage caused by contrast dyes (contrast induced nephropathy). Taking alpha-lipoic acid by mouth with or without standard hydration therapy during a coronary angiography doesn’t seem to prevent kidney damage caused by contrast agents.
• Diabetes. Taking alpha-lipoic acid by mouth or by IV does not improve blood sugar levels in people with type 2 diabetes.
• Vision problems in people with diabetes (diabetic retinopathy). Taking alpha-lipoic acid by mouth daily for 24 months doesn’t improve eye damage from diabetes.
• Dementia in people with advanced HIV/AIDS. Taking alpha-lipoic acid by mouth has no effect on thinking problems in people with HIV.
• High levels of fats called triglycerides in the blood (hypertriglyceridemia). Taking alpha-lipoic acid by mouth doesn’t seem to reduce triglyceride levels in most people.

There is interest in using alpha-lipoic acid for a number of other purposes, but there isn’t enough reliable information to say whether it might be helpful.

Side Effects

When taken by mouth: Alpha-lipoic acid is possibly safe for most adults when taken for up to 4 years. It is usually well-tolerated. The most common side effects are headache, heartburn, nausea, and vomiting.

When applied to the skin: Alpha-lipoic acid is possibly safe for most adults when used as a cream for up to 12 weeks. It might cause a rash in some people.

Special Precautions and Warnings

When taken by mouth: Alpha-lipoic acid is possibly safe for most adults when taken for up to 4 years. It is usually well-tolerated. The most common side effects are headache, heartburn, nausea, and vomiting.

When applied to the skin: Alpha-lipoic acid is possibly safe for most adults when used as a cream for up to 12 weeks. It might cause a rash in some people. Pregnancy: When taken by mouth, alpha-lipoic acid is possibly safe. It’s been used safely during pregnancy in doses of up to 600 mg daily for up to 4 weeks.

Breast-feeding: There isn’t enough reliable information to know if alpha-lipoic acid is safe to use when breast-feeding. Stay on the safe side and avoid use.

Children: Alpha-lipoic acid is possibly safe in children aged 10-17 years when taken by mouth in doses up to 600 mg daily for 3 months. But it is possibly unsafe for children to take large amounts of alpha-lipoic acid by mouth. Seizures, vomiting, and unconsciousness have been reported for children aged 14 months to 16 years who took up to 2400 mg of alpha-lipoic acid as a single dose.

Surgery: Alpha-lipoic acid can decrease blood sugar levels. Alpha-lipoic acid might interfere with blood sugar control during and after surgery. Stop taking alpha-lipoic acid 2 weeks before elective surgical procedures.

Excessive use of alcohol/thiamine deficiency: Alcohol can lower the amount of thiamine (vitamin B1) in the body. Taking alpha-lipoic acid when there is a shortage of thiamine might cause serious health problems. If you drink a lot of alcohol and take alpha-lipoic acid, you should take a thiamine supplement.

Interactions ?

Moderate Interaction

Be cautious with this combination

• Alpha-lipoic acid is an antioxidant. There is some concern that antioxidants might decrease the effects of medications used for cancer. If you are taking medications for cancer, check with your healthcare provider before taking alpha-lipoic acid.

• Alpha-lipoic acid seems to decrease how well thyroid hormone works in the body. Taking alpha-lipoic acid with thyroid hormone might decrease the effects of the thyroid hormone.

• Alpha-lipoic acid is an antioxidant. There is some concern that antioxidants might decrease the effects of some medications used for cancer. If you are taking medications for cancer, check with your healthcare provider before taking alpha-lipoic acid.

• Alpha-lipoic acid might slow blood clotting. Taking alpha-lipoic acid along with medications that also slow blood clotting might increase the risk of bruising and bleeding.

Minor Interaction

Be watchful with this combination

• Alpha-lipoic acid might lower blood sugar levels. Taking alpha-lipoic acid along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.

Dosing

Alpha-lipoic acid has most often been used by adults in doses of 600-1800 mg by mouth daily for up to 6 months. Speak with a healthcare provider to find out what dose might be best for a specific condition.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.

Alpha lipoic acid: indications for use, benefits and harms

Alpha lipoic acid is a super-antioxidant that protects the body’s nerves and cells, significantly reduces mitochondrial wear and tear and increases energy levels, thus improving parameters of longevity during human aging. Its ability to influence inflammation, apoptosis, blood flow, endothelial dysfunction, neurotransmitter activation, and metabolic processes determines its wide application in various fields of medicine.

The antioxidant action of lipoic acid is realized in two ways: directly by neutralizing free radicals, and also by stimulating the production of glutathione in the body – a powerful natural antioxidant with detoxifying properties.

The biochemistry of ALA’s effects on the body is similar to B vitamins. Its main coenzyme function is to participate in the oxidative decarboxylation of α-keto acids, in particular, in the conversion of pyruvate to acetate and carbon dioxide. Reactions of this type are catalyzed by multicomponent enzyme systems involving several coenzymes and include many steps. With a lack of pyruvate dihydrogenase complex, lactic acid will accumulate in the tissues. This happens, for example, during intense physical activity, when our respiratory enzymes become insufficient and we acidify.

Lipoic acid prevents oxidation, prolongs the action of vitamins C and E and coenzyme Q10, participates in the biosynthesis of glutathione in the liver, and also provides the body with the necessary energy. In cells, thioctacid is converted to dihydrolipoic acid, which has protective properties against cellular reactions. Thanks to its antioxidant properties, it helps prevent cell aging and supports optimal functioning of the heart, liver and brain, and improves insulin sensitivity. In addition, thioctic acid is part of the enzymes responsible for the conversion of amino acids with a branched side chain – lycine, isolicin and valine.

An interesting feature of alpha lipoic acid is its chelating property. This means that it can combine with toxic metals (mercury, arsenic, iron), as well as other forms of free radicals, and remove them from the body.

Slimming Lipoic Acid

Alpha Lipoic Acid affects weight loss in many ways. Due to its ability to improve glucose metabolism, it is widely used in obese people. Research has shown that ALA helps improve body composition, reduces belly fat, promotes up to 8% weight loss, and additionally helps reduce high blood pressure. These are all side effects of its ability to improve insulin sensitivity.

Animal studies show that alpha-lipoic acid reduces the activity of the enzyme AMP-activated protein kinase (AMPK), which is located in the hypothalamus of the brain, thus dulling the feeling of hunger.

On the other hand, suppressing AMPK activity can increase the number of calories burned by the body at rest. Animals given alpha-lipoic acid burned more calories. However, human studies show that lipoic acid has only a minor effect on weight loss. The experiment found that the group who took the ALA supplement for 23 weeks lost an average of 1.27 kg more than those who took the placebo. Thus, it has been established that alpha-lipoic acid slightly reduces the percentage of body fat and cellulite, and the maximum effect is achieved only in combination with proper nutrition and physical activity.

Alpha lipoic acid and diabetes mellitus

Alpha lipoic acid is very effective in the treatment of type 2 diabetes. It has been found to reduce blood sugar levels in both animals and humans by up to 64%. Glycemic control ALA improves insulin sensitivity.

Studies in people with metabolic syndrome have shown that lipoic acid can reduce insulin resistance and fasting blood glucose and HbA1c. Scientists believe that it helps normalize blood sugar levels by stimulating the removal of fat stored in muscle cells, which otherwise reduces the effectiveness of insulin.

Lipolyic acid has the property of preventing protein glycosylation and thus preventing the conversion of glucose and galactose to sorbitol. The accumulation of sorbitol is associated with certain pathologies found in people with diabetes, including cataracts. It has also been shown to relieve symptoms of nerve damage and reduce the risk of diabetic neuropathy and retinopathy (eye damage) that can occur with uncontrolled diabetes.

Important! Before using alpha lipoic acid as a treatment for diabetes, you should check with your healthcare provider as it may interact with your medications.

Although lipoic acid helps control blood sugar levels, it is not considered a complete diabetes treatment, but may be recommended during the pre-diabetes stage.

Other health benefits

Studies have shown that lipoic acid has the following positive effects:

• increases energy
• strengthens the immune system
• prevents cell aging
• improves memory performance and brain function
• improves vision
• protects the nervous system
• restores damaged liver cells
• helps to lose weight
• normalizes blood pressure
• has a detox effect
• lowers cholesterol and blood sugar 9 0044

Unlike vitamins, lipoic acid is effective , both in fat and water, making it ideal for protecting brain tissue. Because it is able to cross the blood-brain barrier, it is one of the few antioxidants that can prevent free radical damage to the brain. It is also believed to help strengthen the connective connections between nerve cells, which has a positive effect on sensitivity and reaction time.

In an open-label study of 56 patients with alcoholic polyneuropathy, a decrease in positive and negative neuropathic symptoms was found with a dose of 300 mg daily, and ALA was more effective than thiamine.

May reduce skin aging

All antioxidants are known to have anti-aging effects. Unstable molecules destroy cellular tissue, causing cell death and accelerating the aging of the body. With the help of antioxidants, damage can be avoided, cells remain intact and can reproduce for a longer period of time.

Alpha-lipoic acid is included in anti-aging cosmetics, and can also be used as an independent facial treatment. The anti-aging effect is due to the ability to prevent the glycation of collagen, which is responsible for the elasticity of the dermis. Sugar is known to contribute to premature skin aging. As a result of excessive consumption of carbohydrates, the process of glycation occurs, when sugar residues stick together with collagen and elastin fibers, causing the skin to lose its firmness. ALA prevents this process and slows down the aging of the skin.

The anti-aging effect of lipoic acid on the skin is supported by human studies, which have shown that applying a cream containing alpha lipoic acid reduces fine lines, wrinkles, age spots and skin roughness without side effects.

Alpha Lipoic Acid penetrates the inner layers of the skin and provides antioxidant protection against harmful solar UV radiation. In addition, it increases the levels of other antioxidants, such as glutathione, which help protect the skin from damage and may reduce signs of aging.

May slow down memory loss

Memory loss is a common problem among older people. Damage from oxidative stress is thought to play a critical role in this disease. Given the antioxidant properties of alpha lipoic acid, studies have been conducted on its ability to slow the progression of disorders characterized by memory loss.

ALA has been shown to support brain and other organ function and slow the progression of Alzheimer’s disease by neutralizing free radicals and suppressing inflammation. In the fibroblasts of patients with Alzheimer’s disease, pronounced oxidative stress associated with mitochondrial dysfunction was revealed. In the treatment of Alzheimer’s disease, alpha-lipoic acid is considered as one of the methods of neuroprotection.

Thus, the complex nature of the action of lipoic acid on cognitive functions, daily activity, emotional and somatic state in patients with cerebral vascular events has been established. A positive effect has been demonstrated in relation to the consequences of traumatic brain injuries, Alzheimer’s and Parkinson’s diseases.

In addition, animal experiments have shown the ability of lipoic acid to prevent hearing loss in the elderly, as well as potential benefits in the treatment of glaucoma.

However, studies on the relationship between alpha-lipoic acid and memory loss are lacking, so more data is needed before it can be used for treatment.

Promotes healthy nerve function

Research has shown that vitamin N promotes healthy nerve function. It slows the progression of carpal tunnel syndrome in the early stages. This condition is characterized by numbness or tingling in the hand caused by a pinched nerve. In addition, taking alpha-lipoic acid before and after surgery for carpal tunnel syndrome has been found to improve recovery outcomes. Another important action of alpha-lipoic acid is the ability to relieve the symptoms of diabetic neuropathy, which occurs in the form of acute nerve pain in uncontrolled diabetes.

Studies conducted by the Moscow State University staff also revealed that lipoic acid restores the damaged structure of the brain tissue, prevents the death of nerve cells and increases their resistance to neurodegenerative changes.

Because ALA plays an important role in increasing cellular energy production, it may be a natural remedy for chronic fatigue syndrome. Some relatively recent studies have shown that lipoate may be useful as a natural remedy for headaches and migraines: a dose of 600 mg per day reduces the intensity and frequency of their occurrence.

Reduces inflammation

Chronic inflammation is associated with various diseases including cancer and diabetes. Alpha-lipoic acid has been shown to reduce several markers of inflammation by regulating cytokines, sinal molecules. According to an analysis of 11 studies, it significantly reduces levels of the inflammatory marker C-reactive protein (CRP) in adults with high CRP levels. In test-tube studies, alpha-lipoic acid reduced inflammatory markers including NF-kB, ICAM-1, VCAM-1, MMP-2, MMP-9and IL-6.

Pilot studies have shown that ALA reduces cell death due to oxidative stress but stimulates apoptosis in various cancer cells. In a laboratory experiment, it has been shown that it inhibits the proliferation of human breast cancer cells and activates the process of apoptosis (death) in them. The same results were obtained for lung cancer cells.

Vitamin N strengthens the immune system along with other antioxidants such as vitamin C, bioflavonoids or omega-3, stimulates the production of interferon against infections, inflammation, allergies and more.

May reduce risk factors for heart disease

With its ability to lower high blood pressure by normalizing blood lipids by reducing plaque buildup in blood vessels, alpha-lipoic acid may be beneficial in improving the cardiovascular system.

Laboratory studies in animals and humans have shown that the antioxidant properties of lipoic acid can reduce several risk factors for heart disease. First, taking thioctic acid reduces oxidative stress, which increases the risk of heart disease. Second, it improves endothelial dysfunction, a condition in which blood vessels fail to dilate properly, which also increases the risk of heart attack and stroke. In addition, ALA has the ability to regenerate vitamin E, an antioxidant that also has beneficial effects on cardiovascular function.

It was experimentally proven that the administration of lipoic acid reduced the size of atherosclerotic plaques in the abdominal aorta, which was accompanied by a decrease in the content of fatty and inflammatory cells in the aortic wall. The use of ALA improves the vascular response to angiotensin II, acetylcholine and insulin, reduces free radical damage to myocytes due to oxidative stress during myocardial ischemia.

Alpha Lipoic Acid in Bodybuilding

Intense athletic training is known to increase free radical production, which means that endogenous antioxidants such as glutathione or vitamin E will be reduced, leading to increased oxidative stress and tissue damage. High oxidative stress alters the regulation of muscle contraction and may even affect myofibrillar proteins.

Lipoic acid supplements protect the body from excess free radicals that attack it during physical activity. ALA increases mitochondrial activity, reduces peroxidation and promotes energy synthesis. It helps mobilize glucose into muscle cells, improves glucose utilization and reduces muscle fatigue.

instructions for use, dosage, composition, analogues, side effects / Pillintrip

Page reviewed by pharmacist Kovalenko Svetlana Olegovna Last updated 2020-03-21

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Painex 25VitA-POSArtificial TearSolaraze 3%Arovit

Name of the medicinal product

The information provided in section Name of the medicinal product Ala is based on data from another medicinal product with exactly the same composition as medicinal product Ala . Be
carefully and be sure to check the information on section Name of the drug
in the instructions for the drug Ala directly from the package or from the pharmacist in the pharmacy.

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Ala

Composition

The information provided in section Composition Ala is based on data from another medicine with exactly the same composition as medicine Ala . Be
carefully and be sure to specify the information on section Composition
in the instructions for the drug Ala directly from the package or from the pharmacist in the pharmacy.

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Aminolevulinic Acid

Formulations

The information provided in section Formulations Ala is based on data from another medicine with exactly the same composition as medicine Ala . Be
carefully and be sure to specify the information in section Release forms
in the instructions for the drug Ala directly from the package or from the pharmacist in the pharmacy.

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Substance powder

Therapeutic indications

The information provided in section Therapeutic indications Ala is based on data from another medicine with exactly the same composition as medicine Ala . Be
carefully and be sure to check the information under section Therapeutic indications
in the instructions for the medicine Ala directly from the package or from the pharmacist in the pharmacy.

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Fluorescent diagnostics and photodynamic therapy of superficial skin tumors (excluding melanoma).

Fluorescent diagnostics of malignant neoplasms of the bladder, mucous membrane of the oral cavity and digestive tract, larynx, trachea, bronchi.

Dosage and Administration

Provided under Section Dosage and Administration Ala the information is based on another drug with exactly the same composition as drug Ala . Be
carefully and be sure to check the information on section Dosage and administration
in the instructions for the drug Ala directly from the package or from the pharmacist in the pharmacy.

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Locally, instillation, inhalation and inside.

Ala is applied as a 5%, 10% or 20% ointment topically; 1.5 or 3% sterile solution by instillation, 10% sterile solution by inhalation and oral solution at doses of 10–50 mg/kg. The ointment with the drug is applied in a uniform thin layer to the affected area once or repeatedly (2-4 times with an interval of 6-7 days) 4-6 hours before fluorescent diagnostics and photodynamic therapy. During instillation: 50 ml of the solution is injected through the catheter into the bladder 1. 5–2 hours before the fluorescent diagnostic session. Inhalation is carried out for 30-40 minutes 1.5-2 hours before fluorescent diagnostics. When taken orally, the drug is dissolved in 200 ml of drinking water and taken 3-6 hours before fluorescent diagnostics.

Preparation of dosage form

Preparation of ointment for application: salts of ethylenediaminetetraacetic acid ( EDTA) and 2% dimexide (the solution should be clear). The solution is cooled to 25–30 °C. To obtain 1 dose of 5, 10 or 20% ointment, 0.125, 0.25 or 0.5 g of Alaa, respectively, are dissolved in 0.6 ml of the resulting solution and mixed with 1.2 g of lanolin until a homogeneous mass is obtained that does not delaminate within 10 minutes . 0.2 g of vaseline is added to the resulting mixture and mixed again until a homogeneous mass is obtained.

The ointment should be prepared no more than 24 hours before use.

Preparation of sterile solution for instillation: to obtain 1. 5 or 3% solutions, 0.75 or 1.5 g of Alaa, respectively, is dissolved in 50 ml of sterile 5% sodium bicarbonate solution.

The solution should be prepared immediately before use.

Preparation of a sterile solution for inhalation: to obtain a 10% sterile solution, 1 or 1.5 g of Alaa is dissolved in 10 or 15 ml of a 5% sodium bicarbonate solution, respectively.

The solution should be prepared immediately before use.

Preparation of a sterile solution for oral administration: the required amount of the drug is dissolved in 200 ml of non-carbonated drinking water.

The solution should be prepared immediately before use.

Conducting fluorescent diagnostics

Fluorescent diagnostic examination of patients is carried out 4-6 hours after applying the ointment, 1.5-2 hours after instillation or inhalation of Alaa solution, 3-6 hours after taking the drug solution inside. As a source of radiation that excites the fluorescence of protoporphyrin IX in tissues, when examining patients, optical radiation sources from Karl Storz and Richard Wolf (Germany), Olimpas (Japan) with a wavelength in the range from 385 to 440 nm are used. The resulting two-dimensional fluorescent image is observed using a video system.

Photodynamic therapy

Irradiation of superficial skin tumors is carried out immediately after the completion of fluorescence diagnostics using optical radiation sources with a wavelength of 630–675 nm. Radiation power density — 100–300 mW/cm ² , energy density — 100–200 J/cm ² .

Contraindications

The information provided in section Contraindications Ala is based on data from another medicine with exactly the same composition as medicine Ala . Be
carefully and be sure to check the information on section Contraindications
in the instructions for the drug Ala directly from the package or from the pharmacist in the pharmacy.

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Hypersensitivity to the drug.

Adverse effects

The information provided in section Adverse effects Ala is based on data from another medicine with exactly the same composition as medicine Ala . Be
carefully and be sure to check the information in section Side effects of
in the instructions for the drug Ala directly from the package or from the pharmacist in the pharmacy.

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Allergic reactions possible.

In the first hours after topical application of the ointment with Ala, when exposed to bright sunlight, local phototoxic reactions of the skin in the area of ​​application of the ointment are possible.

Overdose

The information provided in section Overdose Ala is based on data of another medicine with exactly the same composition as the medicine Ala . Be
carefully and be sure to check the information on section Overdose
in the instructions for the drug Ala directly from the package or from the pharmacist in the pharmacy.

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Symptoms: transient increase in liver transaminase activity (with a significant excess of doses).

Pharmacodynamics

The information provided in section Pharmacodynamics Ala is based on data of another medicine with exactly the same composition as the medicine Ala . Be
carefully and be sure to check the information on section Pharmacodynamics
in the instructions for the drug Ala directly from the package or from the pharmacist in the pharmacy.

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5-aminolevulinic acid (5-ALA) is a precursor of protoporphyrin IX in the human body. The mechanism of action is based on the ability of tumor cells to increase the accumulation of photoactive protoporphyrin IX in the presence of exogenous 5-ALA.

The accumulation of protoporphyrin IX in the tumor occurs within 4-6 hours after the skin application of the ointment with Alaom and 1-6 hours after the use of the drug solutions (instillations, inhalations, oral administration). A high fluorescent contrast of the tumor and the surrounding tissue is recorded during the first hour after the end of the ointment application or the use of the drug in the form of a solution and reaches 2–30 times. This allows, when performing fluorescent diagnostics, to refine the boundaries of tumors and identify visually undetectable tumor formations for subsequent organ-preserving treatment (electroresection, etc.) without damaging the tissue surrounding the tumor, or to conduct effective photodynamic therapy of superficial tumors.

Pharmacokinetics

The information provided in section Pharmacokinetics of Ala is based on data from another medicine with exactly the same composition as the medicine Ala . Be
carefully and be sure to specify the information on section Pharmacokinetics
in the instructions for the drug Ala directly from the package or from the pharmacist in the pharmacy.

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Within 48 hours after external application of the ointment with Alaom, instillation and inhalation of the drug solutions in recommended doses, the vast majority of patients do not experience an increase in the concentration of protoporphyrin IX in the blood plasma. In some cases, as well as when Alaa solution is taken orally, an increase in protoporphyrin IX in the blood can be observed for 6-9 hours. In the urine of most patients, protoporphyrin IX is also not detected and there are no statistically significant changes in the content of intermediates in the synthesis of porphyrins. It is possible to increase the concentration and total amount of excreted pigments in the urine within 3–9h after taking Alaa inside.

Interactions

The information provided in section Interactions Ala is based on data from another medicine with exactly the same composition as medicine Ala . Be
carefully and be sure to clarify the information on section Interaction
in the instructions for the drug Ala directly from the package or from the pharmacist in the pharmacy.

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Not found.

Storage

The information provided in section Storage of Ala is based on data from another medicine with exactly the same composition as medicine Ala . Be
carefully and be sure to specify the information on section Storage
in the instructions for the drug Ala directly from the package or from the pharmacist in the pharmacy.

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In a dry, dark place, at a temperature not exceeding 15 °C.

Keep out of reach of children.

Shelf life of 5-aminolevulinic acid hydrochloride preparation 2 years.

Do not use after the expiry date which is stated on the packaging.

Packaging and contents

The information provided in section Packaging and contents Ala is based on data from another medicine with exactly the same composition as medicine Ala . Be
carefully and be sure to check the information on section Packaging and contents of
in the instructions for the drug Ala directly from the package or from the pharmacist in the pharmacy.

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