How does atorvastatin lower cholesterol levels. What are the common side effects of atorvastatin. How should atorvastatin be taken for maximum effectiveness. What precautions should be considered before starting atorvastatin treatment.

Understanding Atorvastatin: A Powerful Cholesterol-Lowering Medication

Atorvastatin, a member of the statin drug class, is widely prescribed to manage cholesterol levels and reduce the risk of cardiovascular events. This medication plays a crucial role in modern preventive cardiology by effectively lowering “bad” cholesterol (LDL) and triglycerides while raising “good” cholesterol (HDL).

How Does Atorvastatin Work?

Atorvastatin functions by inhibiting an enzyme called HMG-CoA reductase, which is responsible for cholesterol production in the liver. By reducing the amount of cholesterol synthesized by the body, atorvastatin helps maintain healthier blood lipid profiles. This mechanism of action contributes to a decreased risk of heart disease, strokes, and heart attacks.

Proper Usage and Administration of Atorvastatin

To maximize the benefits of atorvastatin while minimizing potential side effects, it’s essential to follow the prescribed dosage and administration guidelines carefully.

Dosage and Timing

Atorvastatin is typically taken once daily, preferably at the same time each day to maintain consistent blood levels. The medication should be taken on an empty stomach, either one hour before or two hours after a meal. This timing ensures optimal absorption and effectiveness of the drug.

Special Considerations for Liquid Formulation

For patients prescribed the oral suspension form of atorvastatin:

• Shake the bottle well before each dose to ensure proper mixing of the medication.
• Use a special measuring device or spoon provided by your pharmacist to measure the correct dose accurately.
• Avoid using household spoons, as they may not provide the precise measurement required.

Interactions with Food and Other Medications

Certain foods and medications can interact with atorvastatin, affecting its efficacy or increasing the risk of side effects:

• Grapefruit and grapefruit juice should be avoided unless specifically approved by your healthcare provider, as they can increase the concentration of atorvastatin in the blood.
• If you’re taking bile acid-binding resins (e.g., cholestyramine or colestipol), ensure a gap of at least 1 hour before or 4 hours after taking atorvastatin to prevent interference with absorption.

Potential Side Effects of Atorvastatin: What to Watch For

While atorvastatin is generally well-tolerated, it’s important to be aware of potential side effects and know when to seek medical attention.

Common Side Effects

Most side effects of atorvastatin are mild and may include:

• Muscle pain or weakness
• Digestive issues such as nausea or constipation
• Headache
• Joint pain

Rare but Serious Side Effects

In rare cases, atorvastatin may cause more serious side effects that require immediate medical attention:

1. Rhabdomyolysis: A severe form of muscle damage that can lead to kidney failure
2. Liver problems: Characterized by symptoms such as yellowing of the skin or eyes, dark urine, and abdominal pain
3. Allergic reactions: Including rash, itching, swelling, or difficulty breathing
4. Cognitive effects: Rarely, some patients may experience memory problems or confusion

If you experience any of these serious side effects, it’s crucial to contact your healthcare provider immediately.

Lifestyle Modifications to Enhance Atorvastatin’s Effectiveness

While atorvastatin is a powerful tool in managing cholesterol levels, combining medication with lifestyle changes can significantly improve outcomes.

Diet and Nutrition

A heart-healthy diet is essential for maximizing the benefits of atorvastatin:

• Focus on consuming plenty of fruits, vegetables, and whole grains
• Choose lean proteins and healthy fats, such as those found in fish and nuts
• Limit saturated and trans fats, which can raise LDL cholesterol levels
• Reduce intake of refined sugars and processed foods

Exercise and Physical Activity

Regular physical activity complements the effects of atorvastatin by further improving lipid profiles and overall cardiovascular health:

• Aim for at least 150 minutes of moderate-intensity aerobic exercise per week
• Include strength training exercises to build muscle mass and improve metabolism
• Find activities you enjoy to make exercise a sustainable part of your routine

Weight Management

Maintaining a healthy weight can enhance the effectiveness of atorvastatin and reduce cardiovascular risk:

• If overweight, even modest weight loss can significantly improve cholesterol levels
• Combine a balanced diet with regular exercise for sustainable weight management
• Consult with a healthcare provider or registered dietitian for personalized weight loss strategies

Precautions and Considerations Before Starting Atorvastatin

Before initiating atorvastatin therapy, it’s crucial to discuss your medical history and current medications with your healthcare provider to ensure safe and effective treatment.

Medical Conditions

Certain medical conditions may affect the use of atorvastatin or require special monitoring:

• Liver disease: Atorvastatin can affect liver function, so patients with pre-existing liver conditions may require closer monitoring
• Kidney disease: Dosage adjustments may be necessary for patients with impaired kidney function
• Diabetes: Statins may slightly increase blood sugar levels, requiring careful management in diabetic patients
• Thyroid disorders: Hypothyroidism can increase the risk of muscle-related side effects from statins

Medication Interactions

Atorvastatin can interact with various medications, potentially altering its effectiveness or increasing the risk of side effects:

• Antibiotics: Certain antibiotics can increase the concentration of atorvastatin in the blood
• Antifungal medications: Some antifungals may interact with atorvastatin metabolism
• HIV medications: Protease inhibitors and other HIV drugs can affect statin levels
• Other cholesterol-lowering medications: Combining atorvastatin with fibrates or niacin requires careful monitoring

Always inform your healthcare provider about all medications, supplements, and herbal products you are taking to avoid potential interactions.

Long-Term Benefits and Cardiovascular Risk Reduction with Atorvastatin

Consistent use of atorvastatin, in combination with lifestyle modifications, can lead to significant long-term benefits in cardiovascular health.

Primary Prevention

For individuals without a history of cardiovascular disease but with risk factors such as high cholesterol, atorvastatin can help:

• Reduce the risk of first-time heart attacks and strokes
• Slow the progression of atherosclerosis (hardening of the arteries)
• Improve overall cardiovascular risk profiles

Secondary Prevention

In patients with established cardiovascular disease, atorvastatin plays a crucial role in:

• Reducing the risk of recurrent cardiovascular events
• Improving long-term survival rates
• Enhancing quality of life by reducing cardiovascular complications

Beyond Cholesterol: Pleiotropic Effects

Research suggests that atorvastatin may have additional benefits beyond cholesterol reduction, including:

• Anti-inflammatory effects that may contribute to cardiovascular protection
• Potential improvements in endothelial function
• Possible stabilization of atherosclerotic plaques, reducing the risk of rupture

Monitoring and Follow-Up: Ensuring Optimal Atorvastatin Therapy

Regular monitoring and follow-up are essential components of successful atorvastatin therapy, allowing for timely adjustments and early detection of potential issues.

Lipid Profile Testing

Periodic lipid profile tests help assess the effectiveness of atorvastatin treatment:

• Initial follow-up testing is typically done 4-12 weeks after starting therapy
• Subsequent testing frequency depends on individual response and risk factors
• Target LDL levels are determined based on individual cardiovascular risk

Liver Function Monitoring

Given the potential for liver-related side effects, liver function tests are an important part of atorvastatin monitoring:

• Baseline liver function tests are usually performed before starting treatment
• Follow-up tests may be conducted periodically, especially in the first year of therapy
• Any significant elevations in liver enzymes should be promptly evaluated

Muscle-Related Symptom Assessment

Regular assessment of muscle-related symptoms is crucial for early detection of potential myopathy:

• Patients should report any unexplained muscle pain, tenderness, or weakness
• Creatine kinase levels may be checked if muscle symptoms are reported
• Prompt discontinuation of atorvastatin may be necessary if severe muscle symptoms occur

By adhering to a comprehensive monitoring plan, patients and healthcare providers can optimize the benefits of atorvastatin therapy while minimizing potential risks.

Special Populations and Atorvastatin Use: Tailoring Treatment to Individual Needs

While atorvastatin is widely prescribed, certain populations may require special considerations or modified approaches to treatment.

Elderly Patients

Older adults may be more susceptible to certain side effects of atorvastatin:

• Lower starting doses may be recommended to assess tolerability
• Closer monitoring for muscle-related symptoms is often necessary
• Potential drug interactions should be carefully evaluated due to common polypharmacy in this population

Pregnant and Breastfeeding Women

Atorvastatin use during pregnancy and breastfeeding requires careful consideration:

• Atorvastatin is generally contraindicated during pregnancy due to potential risks to fetal development
• Women of childbearing age should use effective contraception while taking atorvastatin
• Breastfeeding while on atorvastatin is not recommended due to potential transfer to breast milk

Pediatric Patients

Atorvastatin may be prescribed to children with certain genetic lipid disorders:

• Use is typically limited to children aged 10 years and older
• Dosing and monitoring may differ from adult protocols
• Long-term effects on growth and development require ongoing research and monitoring

Patients with Genetic Lipid Disorders

Individuals with familial hypercholesterolemia or other genetic lipid disorders may require specialized management:

• Higher doses of atorvastatin may be necessary to achieve target lipid levels
• Combination therapy with other lipid-lowering agents is often employed
• Regular monitoring and adjustment of treatment plans are crucial for optimal outcomes

By tailoring atorvastatin treatment to the specific needs of these populations, healthcare providers can maximize therapeutic benefits while minimizing potential risks.

Atorvastatin Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Uses

Atorvastatin is used along with a proper diet to help lower “bad” cholesterol and fats (such as LDL, triglycerides) and raise “good” cholesterol (HDL) in the blood. It belongs to a group of drugs known as “statins.” It works by reducing the amount of cholesterol made by the liver. Lowering “bad” cholesterol and triglycerides and raising “good” cholesterol decreases the risk of heart disease and helps prevent strokes and heart attacks.In addition to eating a proper diet (such as a low-cholesterol/low-fat diet), other lifestyle changes that may help this medication work better include exercising, losing weight if overweight, and stopping smoking. Consult your doctor for more details.

How to use Atorvastatin 20 Mg/5 Ml (4 Mg/Ml) Oral Suspension

Read the Patient Information Leaflet if available from your pharmacist before you start taking atorvastatin and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth as directed by your doctor, usually once daily. It should be taken on an empty stomach, 1 hour before or 2 hours after a meal.

The dosage is based on your medical condition, response to treatment, age, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Shake the bottle well before each dose. Carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.

Avoid eating grapefruit or drinking grapefruit juice while using this medication unless your doctor or pharmacist says you may do so safely. Grapefruit can increase the chance of side effects with this medicine. Ask your doctor or pharmacist for more details.

If you also take certain other drugs to lower your cholesterol (bile acid-binding resins such as cholestyramine or colestipol), take atorvastatin at least 1 hour before or at least 4 hours after taking these medications. These products can react with atorvastatin, preventing its full absorption.

Take this medication regularly in order to get the most benefit from it. Remember to take it at the same time each day. Keep taking this medication even if you feel well. Most people with high cholesterol or triglycerides do not feel sick.

It is very important to continue to follow your doctor’s advice about diet and exercise. It may take up to 4 weeks before you get the full benefit of this drug.

Side Effects

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A very small number of people taking atorvastatin may have mild memory problems or confusion. If these rare effects occur, talk to your doctor.

Rarely, statins may cause or worsen diabetes. Talk to your doctor about the benefits and risks.

This drug may rarely cause muscle problems (which can rarely lead to very serious conditions called rhabdomyolysis and autoimmune myopathy). Tell your doctor right away if you develop any of these symptoms during treatment and if these symptoms last after your doctor stops this drug: muscle pain/tenderness/weakness (especially with fever or unusual tiredness), signs of kidney problems (such as change in the amount of urine).

This medication may rarely cause liver problems. Tell your doctor right away if you develop symptoms of liver problems, including: nausea/vomiting that doesn’t stop, yellowing eyes/skin, dark urine, stomach/abdominal pain.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking atorvastatin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, alcohol use.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Limit alcoholic beverages. Daily use of alcohol may increase your risk for liver problems, especially when combined with atorvastatin. Ask your doctor or pharmacist for more information.

Older adults may be more sensitive to the side effects of this drug, especially muscle problems.

During pregnancy, this medication should be used only when clearly needed. It may harm an unborn baby. Discuss the risks and benefits with your doctor.

It is unknown if this medication passes into breast milk. Because of the possible risk to the infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.

Interactions

See also How to Use section.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Some products that may interact with this drug include: daptomycin, gemfibrozil.

Other medications can affect the removal of atorvastatin from your body, which may affect how atorvastatin works. Examples include glecaprevir plus pibrentasvir, telithromycin, ritonavir, among others.

Do not take any red yeast rice products while you are taking atorvastatin because some red yeast rice products may also contain a statin called lovastatin. Taking atorvastatin and red yeast rice products together can increase your risk of serious muscle and liver problems.

Does Atorvastatin 20 Mg/5 Ml (4 Mg/Ml) Oral Suspension interact with other drugs you are taking?

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Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Do not share this medication with others.

Lab and/or medical tests (such as blood cholesterol/triglyceride levels, liver function) should be done while you are taking this medication. Keep all medical and lab appointments. Consult your doctor for more details.

If you miss a dose, take it as soon as you remember unless it is more than 12 hours after the time you usually take the dose. In that case, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature away from light and moisture. Do not store in the bathroom. Store the suspension form in the original container. Discard the suspension form 60 days after opening the bottle, even if there is medication left. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

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Drug Survey

Are you currently using Atorvastatin 20 Mg/5 Ml (4 Mg/Ml) Oral Suspension?

This survey is being conducted by the WebMD marketing sciences department.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Side effects, dosage, uses, and more

1. Atorvastatin oral tablet is available as both a generic drug and a brand-name drug. Brand name: Lipitor.
2. Atorvastatin only comes in the form of a tablet you take by mouth.
3. Atorvastatin oral tablet is used to improve cholesterol levels and decrease your risk for heart attack and stroke. It’s used together with diet, weight loss, and exercise.

• Muscle problems warning: Your risk for myopathy (muscle pain, tenderness, or weakness) and rhabdomyolysis (muscle breakdown) is increased while taking atorvastatin. The risk is greater if you’re a senior, have thyroid problems, or have kidney disease. Tell your doctor right away if you start to have unexplained muscle soreness, pain, or weakness.
• Liver problems warning: Lab tests for your liver may be abnormally high while you’re taking atorvastatin and you may have liver problems. Your doctor will monitor this while you’re taking this drug.
• Increased blood sugars warning: Atorvastatin may increase your blood sugar levels. You and your doctor should monitor your blood sugar levels carefully while you’re taking this drug.

Atorvastatin oral tablet is a prescription drug. It’s available as a brand-name drug called Lipitor. It’s also available in a generic form. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in all strengths or forms as the brand-name drug.

Why it’s used

Atorvastatin is used to improve cholesterol levels in people with different types of cholesterol problems. It’s also used to decrease your risk for heart attack and stroke. It’s used together with diet, weight loss, and exercise.

Atorvastatin helps to prevent cholesterol from building up in your arteries. Clogged arteries can block blood flow to your heart and brain.

Atorvastatin may be used as part of a combination therapy. This means you may need to take it with other medications. These may include bile acid resins and other cholesterol-lowering medications.

How it works

Atorvastatin belongs to a class of drugs called HMG-CoA reductase inhibitors, or statins. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

This drug works by lowering your low-density lipoprotein (LDL) or “bad” cholesterol and raising your high-density lipoprotein (HDL) or “good” cholesterol. Atorvastatin improves your body’s ability to get rid of LDL cholesterol through your liver.

Atorvastatin oral tablet doesn’t cause drowsiness, but it can cause other side effects.

More common side effects

Some of the more common side effects that can occur with the use of atorvastatin oral tablets include:

• cold symptoms such as runny nose, sneezing, and coughing
• diarrhea
• gas
• heartburn
• joint pain
• forgetfulness
• confusion
• urinary tract infection (UTI)

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

• Muscle problems. Symptoms can include:
  • unexplained muscle weakness, tenderness, or pain
  • tiredness
• Liver problems. Symptoms can include:
  • tiredness or weakness
  • loss of appetite
  • upper stomach pain
  • dark urine
  • yellowing of your skin or the whites of your eyes
• Allergic reaction.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.

Atorvastatin oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Examples of drugs that can cause interactions with atorvastatin are listed below.

Antibiotics

Taking atorvastatin with certain antibiotics increases your risk for muscle problems. Examples of these drugs include:

• clarithromycin
• erythromycin

Fungal drugs

Taking atorvastatin with certain drugs used to treat fungal infections may cause atorvastatin to build up in your body. This raises your risk for muscle breakdown. If you need to take these drugs together, your doctor may decrease your dosage of atorvastatin. Examples of these drugs include:

• itraconazole
• ketoconazole

Cholesterol-lowering drugs

Taking atorvastatin with other cholesterol-lowering drugs raises your risk for muscle problems. Your doctor may change your dosage of these medications or have you avoid taking them together. Examples of these drugs include:

• gemfibrozil
• medications that contain fibrate
• niacin

Rifampin

Taking rifampin with atorvastatin may lower the amount of atorvastatin in your body. This means that the atorvastatin may not work as well.

HIV drugs

Taking atorvastatin with certain drugs used to treat HIV may cause atorvastatin to build up in your body. This raises your risk for muscle breakdown. If you need to take these drugs together, your doctor may decrease your dosage of atorvastatin. Examples of these drugs include protease inhibitors such as:

• darunavir
• fosamprenavir
• lopinavir
• ritonavir
• saquinavir
• tipranavir

Digoxin

Taking digoxin with atorvastatin can increase the amount of digoxin in your blood to dangerous levels. If you need to take these drugs together, your doctor will monitor these levels and adjust your medication doses if needed.

Oral birth control pills

Taking atorvastatin with oral birth control pills may increase the levels of oral contraceptive hormones in your blood.

Colchicine

Taking colchicine with atorvastatin raises your risk for muscle breakdown.

Cyclosporine

Taking cyclosporine with atorvastatin raises your risk for muscle breakdown. Your doctor should avoid this combination.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

This drug comes with several warnings.

Allergy warning

Atorvastatin can cause a severe allergic reaction. Symptoms can include:

• swelling of your face, lips, tongue, or throat
• trouble breathing
• trouble swallowing

Call 911 or go to the nearest emergency room if you develop these symptoms. Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

Food interactions warning

Avoid drinking large amounts of grapefruit juice while taking atorvastatin. Drinking grapefruit juice can lead to a buildup of atorvastatin in your blood, which raises your risk for muscle breakdown. Ask your doctor how much grapefruit juice is safe for you.

Alcohol interaction warning

The use of drinks that contain alcohol raises your risk for liver disease from atorvastatin. Talk to your doctor if you drink more than two alcoholic drinks per day.

Warnings for people with certain health conditions

For people with kidney problems: Having kidney problems raises your risk for muscle breakdown while taking atorvastatin. Your doctor may monitor you more closely for muscle problems.

For people with liver disease: You shouldn’t take this drug if you have liver disease, as this medication can increase your liver test results. This means that you may have liver damage. If you have liver problems, talk with your doctor to make sure this drug is safe for you.

For people with diabetes: Atorvastatin may increase your blood sugar levels. Your doctor may adjust your diabetes medications if this happens, and you may need to monitor your blood sugar levels more often than usual while you’re taking this drug.

Warnings for other groups

For pregnant women: Atorvastatin should never be used during pregnancy. Safety in pregnant women is unknown and there’s no apparent benefit of this drug during pregnancy.

Call your doctor right away if you become pregnant while taking this drug.

For women who are breastfeeding: Atorvastatin should not be used during breastfeeding. If you breastfeed your child, talk to your doctor about what medication could be right for you.

For seniors: People over the age of 65 years have a higher risk for muscle breakdown (rhabdomyolysis) while taking atorvastatin.

For children: Atorvastatin hasn’t been studied and shouldn’t be used in children younger than 10 years. This drug has been shown to be safe and effective in children 10–17 years of age.

This dosage information is for atorvastatin oral tablets. All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on:

• your age
• the condition being treated
• how severe your condition is
• other medical conditions you have
• how you react to the first dose

Forms and strengths

Generic: Atorvastatin

• Form: oral tablet
• Strengths: 10 mg, 20 mg, 40 mg, and 80 mg

Brand: Lipitor

• Form: oral tablet
• Strengths: 10 mg, 20 mg, 40 mg, and 80 mg

Dosage for prevention of heart disease

Adult dosage (ages 18–64 years)

• Typical starting dosage: 10–20 mg taken once per day.
• Typical maintenance dosage: 10–80 mg taken once per day.

Child dosage (ages 0–17 years)

Atorvastatin hasn’t been approved for use in children younger than 18 years for the prevention of heart disease.

Senior dosage (ages 65 years and older)

The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This increases your risk for side effects.

Your doctor may start you on a lowered dosage or a different medication schedule. This can help keep levels of this drug from building up too much in your body.

Dosage for dyslipidemia (cholesterol problems)

Adult dosage (ages 18–64 years)

• Typical starting dosage: 10–20 mg taken once per day.
• Typical maintenance dosage: 10–80 mg taken once per day.
• Note: When treating homozygous familial hypercholesterolemia, the dosage is 10–80 mg taken once per day.

Child dosage (ages 10–17 years)

In children, atorvastatin is only used to treat heterozygous familial hypercholesterolemia.

• Typical starting dosage: 10 mg once per day.
• Maximum dosage: 20 mg once per day.

Child dosage (ages 0–9 years)

Atorvastatin hasn’t been studied in children younger than 10 years of age for this purpose. It shouldn’t be used in this age range for this purpose.

Senior dosage (ages 65 years and older)

The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This increases your risk for side effects.

Your doctor may start you on a lowered dosage or a different medication schedule. This can help keep levels of this drug from building up too much in your body.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.

Atorvastatin oral tablet is used for long-term treatment. It comes with risks if you don’t take it as prescribed.

If you stop taking the drug or don’t take it at all: While eating a healthy diet can sometimes improve your cholesterol levels, atorvastatin can help them even more. If you don’t take atorvastatin, your cholesterol levels may not be controlled. This may raise your risk for heart attack or stroke.

If you miss doses or don’t take the drug on schedule: Your medication may not work as well or may stop working completely. For this drug to work well, a certain amount needs to be in your body at all times.

If you take too much: You could have dangerous levels of the drug in your body. You may have the following symptoms:

• diarrhea
• gas
• heartburn
• joint pain
• forgetfulness
• confusion
• unexplained muscle weakness, tenderness, or pain
• loss of appetite
• upper stomach pain
• dark-colored urine
• yellowing of your skin or the whites of your eyes

If you think you’ve taken too much of this drug, call your doctor or seek guidance from the American Association of Poison Control Centers at 1-800-222-1222 or through their online tool. But if your symptoms are severe, call 911 or go to the nearest emergency room right away.

What to do if you miss a dose: Take your dose as soon as you remember. But if you remember just a few hours before your next scheduled dose, take only one dose. Never try to catch up by taking two doses at once. This could result in dangerous side effects.

How to tell if the drug is working: You won’t be able to feel atorvastatin working. Your doctor will measure your cholesterol levels to see how well atorvastatin is working for you. Your doctor may adjust your dosage depending on your cholesterol levels.

Keep these considerations in mind if your doctor prescribes atorvastatin oral tablet for you.

General

• Don’t cut or crush the tablet.

Storage

• Store atorvastatin at room temperature between 68°F (20°C) and 77°F (25°C). Keep it away from high temperatures.
• Don’t store this medication in moist or damp areas, such as bathrooms.

Refills

A prescription for this medication is refillable. You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription.

Travel

When traveling with your medication:

• Always carry your medication with you. When flying, never put it into a checked bag. Keep it in your carry-on bag.
• Don’t worry about airport X-ray machines. They can’t hurt your medication.
• You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled container with you.
• Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.

Clinical monitoring

While you’re being treated with atorvastatin, your doctor will check your cholesterol levels and liver function. This will be done through blood tests.

Your diet

Your doctor may have you follow a low-fat, low-cholesterol diet while you take this drug.

There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you.

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

What helps, side effects, composition

THERE ARE CONTRAINDICATIONS. POSSIBLE SIDE EFFECTS. A SPECIALIST’S CONSULTATION IS REQUIRED. For the heart and blood vesselsCholesterol

The author of the article

Sumenkova Anna Mikhailovna, pharmacist

All authors

The content of the article

• Atorva statin: composition
• Atorvastatin: before or after meals
• Atorvastatin: side effects
• Rosuvastatin or Atorvastatin: which is better
• Liprimar or Atorvastatin: which is better
• Atorvastatin or Atoris: which is better
• Summary
• Ask an expert on the topic of the article vascular diseases . Few people know that one of the main factors in the development of heart and vascular diseases is an increase in the level of cholesterol in the blood. To avoid the risk of violations, a special group of drugs is used – statins. One of these drugs will be discussed in the article.

  Anna Sumenkova, a pharmacist, will talk about Atorvastatin: introduce its composition, rules of administration, side effects, and compare it with analogues.

  Atorvastatin: Composition

  Atorvastatin tablets based on the active ingredient of the same name in dosages of 10 mg, 20 mg, 40 mg and 80 mg. The drug is produced by many manufacturers, as well as as part of complex preparations, so it is impossible to derive a single composition of auxiliary agents. The drug can be found under trade names:

  • Atoris
  • Vasator
  • Liprimar
  • Tulip

  The pharmacist says: “Atorvastatin is usually prescribed by general practitioners and cardiologists as part of the complex treatment of cardiovascular diseases. Therefore, when they come to the pharmacy to buy prescribed drugs, people ask a logical question: what do Atorvastatin tablets help with.

  Atorvastatin is a lipid-lowering agent. In other words, the drug reduces the content of “bad” cholesterol in the blood. Due to this, it is used to treat hypercholesterolemia and reduce the risk of complications of heart and vascular diseases. For example, atherosclerosis and coronary heart disease.

  Atorvastatin before or after meals

  Atorvastatin tablets are taken by mouth regardless of food intake. It is important to note that before and during the use of the drug, it is recommended to follow a diet: minimize fat intake and completely abandon butter and palm oil.

  If you ask about the compatibility of Atorvastatin and alcohol, then the answer will be ambiguous. The intake of alcoholic beverages is not contraindicated when using the drug. However, abuse of Atorvastatin is not recommended, as active liver disease and elevated liver enzymes are on the list of contraindications. Therefore, it is important to be careful when taking medication and alcohol-containing drinks together.

  Atorvastatin: side effects

  • Nasopharyngitis – inflammation of the mucous membranes of the nasal cavity and pharynx
  • Allergic reactions: urticaria, pruritus
  • Increase or decrease in blood glucose
  • Headache
  • The appearance of a “veil” before the eyes
  • Tinnitus
  • Sore throat and epistaxis
  • Constipation or diarrhea
  • Nausea
  • Inflammation of the liver
  • Pain in muscles, joints and limbs
  • Increased liver enzymes

  Rosuvastatin or Atorvastatin: which is better

  Rosuvastatin and Atorvastatin belong to the same group of drugs – statins, but they belong to different generations. Atorvastatin is an earlier drug belonging to the third generation of drugs, while Rosuvastatin is the fourth – more modern. Therefore, the activity of Rosuvastatin against “bad” cholesterol is higher. So, Rosuvastatin is effective in doses from 5 mg to 40 mg, and Atorvastatin from 10 mg to 80 mg.

  Rosuvastatin also causes fewer side effects. However, its cost is higher. Only a doctor can replace Atorvastatin with Rosuvastatin.

  All products Rosuvastatin

  20 reviews

  Liprimar or Atorvastatin: which is better

  Liprimar is an original American drug, the active ingredient of which is Atorvastatin. Other Atorvastatin preparations have been replicated based on Liprimar’s evidence base.

  The drugs are similar: they have identical indications for use, dosages, contraindications, and are well tolerated by the body. Substituting one drug for another can be done at the pharmacy based on personal preference and affordability.

  All products Liprimar

  8 reviews

  Atorvastatin or Atoris: which is better

  Atoris is another drug with Atorvastatin as the active substance. Produced in Slovenia in dosages of 10 and 20 mg. The situation is similar with Liprimar: the drugs are similar in all therapeutic indicators.

  Atoris disadvantage: no 40mg dosage, causing patients requiring higher dosages to take more tablets. For example, if you need the highest dose of 80 mg, you will have to drink 8 tablets of 10 mg or 4 tablets of 20 mg.

  All products Atorvastatin

  22 reviews

  All products Atoris

  20 reviews

  Summary

  • Atorvastatin – tablets based on the same active ingredient in dosages of 10 mg, 20 mg, 40 mg and 80 mg.
  • Atorvastatin reduces the content of “bad” cholesterol in the blood.
  • Atorvastatin tablets are taken by mouth regardless of food intake.
  • Rosuvastatin and Atorvastatin belong to the same group of drugs – statins, but to different generations.
  • The activity of Rosuvastatin against “bad” cholesterol is higher.
  • Liprimar is an original American drug, the active ingredient of which is Atorvastatin.
  • Atoris is another drug with Atorvastatin as the active ingredient.

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  Atorvastatin :: Instructions :: Price :: Description of the drug

  Atorvastatin (Atorvastatin)

  statin 10 contains:
  Calcium salt of atorvastatin (in terms of atorvastatin) – 10 mg;
  Additional ingredients including lactose.

  1 film-coated tablet of Atorvastatin 20 contains:
  Calcium salt of atorvastatin (in terms of atorvastatin) – 20 mg;
  Additional ingredients including lactose.

  1 film-coated tablet of Atorvastatin 40 contains:
  Calcium salt of atorvastatin (in terms of atorvastatin) – 40 mg;
  Additional ingredients including lactose.

  1 film-coated tablet of Atorvastatin 80 contains:
  Calcium salt of atorvastatin (in terms of atorvastatin) – 80 mg;
  Additional ingredients including lactose.

  Atorvastatin is a hypocholesterolemic drug. Atorvastatin selectively and competitively inhibits HMG-CoA reductase, an enzyme that regulates the rate of conversion of HMG-CoA to mevalonate, which is a precursor of sterols, including cholesterol.
  In patients with heterozygous and homozygous familial hypercholesterolemia, as well as non-hereditary hypercholesterolemia and mixed dyslipidemia, when taking atorvastatin, there is a decrease in low-density lipoprotein cholesterol, total cholesterol and apolipoprotein B. In addition, atorvastatin reduces the level of very low density lipoprotein and triglycerides. Reception of atorvastatin contributes to some increase in the level of high-density lipoprotein.
  The decrease in plasma cholesterol and lipoprotein levels under the action of atorvastatin occurs due to a decrease in the activity of HMG-CoA reductase and a decrease in cholesterol synthesis in the liver, as well as an increase in the number of LDL receptors on the surface of liver cells, which contributes to an increase in the uptake and catabolism of LDL.

  Atorvastatin reduces the risk of ischemia and mortality in patients of all ages with non-Q wave myocardial infarction and unstable angina. In addition, atorvastatin reduces the risk of fatal cardiovascular disease, reduces the overall incidence of cardiovascular disease, as well as the frequency of fatal and non-fatal stroke.
  After oral administration, atorvastatin is rapidly absorbed in the digestive tract and reaches peak plasma concentrations within 1-2 hours. Plasma concentrations of atorvastatin are dose proportional. The absolute bioavailability of atorvastatin when taken orally is low and reaches 12%, which is associated with the presystemic clearance of atorvastatin in the mucosa of the digestive tract, as well as the effect of “first pass through the liver”. About 98% of the dose taken is bound to plasma proteins, atorvastatin is metabolized in the liver with the formation of pharmacologically active metabolites (in vitro activity of ortho- and parahydroxylated compounds was similar to that of unchanged atorvastatin) and inactive substances.
  Atorvastatin weakly inhibits cytochrome P450 3A4.

  Atorvastatin and its metabolites are excreted primarily by the liver. For atorvastatin, enterohepatic recirculation is practically not characteristic. The half-life of atorvastatin is about 14 hours, but the inhibitory activity against HMG-CoA reductase persists for 20-30 hours after a single dose of atorvastatin. Less than 2% of the administered dose of atorvastatin is excreted by the kidneys.
  There is no significant difference in the pharmacokinetics of atorvastatin in people of different sex and age (excluding children in whom the pharmacokinetics of atorvastatin have not been studied), as well as in patients with normal and reduced renal function.
  Atorvastatin is not excreted by hemodialysis.
  In patients with impaired liver function, there is a significant increase in plasma concentrations of unchanged atorvastatin.
  No carcinogenic effect of atorvastatin has been found in animal studies.

  Atorvastatin is used in complex therapy (combined with diet and exercise) in patients with elevated levels of total cholesterol, apolipoprotein B, triglycerides and low-density lipoprotein cholesterol.
  Atorvastatin is indicated to increase high-density lipoprotein cholesterol in patients with primary hypercholesterolemia (heterozygous familial hypercholesterolemia and non-hereditary hypercholesterolemia), as well as combined hyperlipidemia (Fredrickson type IIa and IIb), elevated plasma triglycerides (Fredrickson type IV) and patients with dysbetalipoproteinemia (Fredrickson type III) if the diet does not give the desired effect.
  Atorvastatin is used to lower total cholesterol and low-density lipoprotein cholesterol in patients with homozygous familial hypercholesterolemia (if diet fails).

  Atorvastatin may be indicated in patients who do not have symptoms of cardiovascular disease (with or without dyslipidaemia), but who have several risk factors for cardiovascular disease (including arterial hypertension, diabetes mellitus, smoking, low high-density lipoprotein cholesterol levels or a family history of cardiovascular disease at a young age). In such patients, Atorvastatin is indicated to reduce the risk of non-fatal myocardial infarction and fatal manifestations of coronary heart disease, as well as to reduce the risk of stroke, angina pectoris and the need for myocardial revascularization procedures.

  In pediatric practice, Atorvastatin is used to treat children aged 10 to 17 years with elevated levels of total cholesterol, apolipoprotein B, low-density lipoprotein cholesterol with heterozygous familial hypercholesterolemia. The appointment of atorvastatin is reasonable in case of ineffective diet (if the level of LDL-C is kept above 190 mg / dl). Atorvastatin should also be considered if the diet is not effective enough and there are additional risk factors (if LDL-C is maintained above 160 mg/dL and there is a family history of cardiovascular disease at a young age or if the child has multiple cardiovascular risk factors). including diabetes mellitus, hypertension, smoking, low HDL-C).

  Atorvastatin is for oral use. Before starting therapy with atorvastatin, the level of hypercholesterolemia should be studied with appropriate diet, exercise and other measures aimed at reducing body weight in obese patients. In addition, therapy for other diseases should also be carried out before starting atorvastatin. Reception of the drug Atorvastatin should be carried out against the background of a standard anti-cholesterol diet. The daily dose of the drug, as a rule, is taken at a time, regardless of the meal. Doses of the drug Atorvastatin and the duration of therapy are determined by the doctor, taking into account the patient’s condition, the level of hypercholesterolemia and the tolerability of atorvastatin.

  Primary hypercholesterolemia and mixed hyperlipidemia are usually treated with atorvastatin at an initial dose of 10 mg daily. After 2-4 weeks after the start of therapy, taking into account the dynamics of the disease, the dose of atorvastatin is adjusted.
  Homozygous familial hypercholesterolemia is usually treated with 40-80 mg of atorvastatin per day (80 mg per day can reduce low-density lipoprotein cholesterol by 18-45%).
  For heterozygous hypercholesterolemia, children aged 10 to 17 years are usually treated with atorvastatin at an initial dose of 10 mg daily. If necessary, after 2-4 weeks after the start of therapy, the dose is increased to 20 mg of atorvastatin per day.

  Elderly patients and patients with impaired renal function do not require dose adjustment of atorvastatin.
  The maximum recommended daily dose for adults is 80 mg of atorvastatin.
  In pediatric practice, atorvastatin doses greater than 20 mg per day should not be used.
  Before starting therapy, check liver function and periodically monitor liver function during therapy (in case of an increase in the activity of alanine aminotransferase and aspartate aminotransferase more than 3 times higher than normal, atorvastatin should be discontinued).

  When taking Atorvastatin, patients may develop the following adverse reactions:
  From the nervous system: insomnia, peripheral neuropathy, paresthesia, headache, asthenia.
  From the musculoskeletal system: myopathy, myositis, convulsions, muscle pain.
  From the digestive tract and metabolism: loss of appetite, vomiting, nausea, stool disorders, flatulence, pancreatitis, pain in the epigastric region, dyspepsia, changes in plasma glucose levels.
  From the hepatobiliary system: jaundice, cholestasis, hepatitis.
  Allergic reactions: urticaria, alopecia, pruritus.
  Other: erectile dysfunction.

  When using the drug Atorvastatin in pediatric practice (in the treatment of children from 10 to 17 years old), the development of such undesirable effects was noted:
  From the side of hematopoietic systems: thrombocytopenia.
  From the side of metabolism and digestive tract: weight gain, pain in the epigastric region, nausea.
  From the nervous system: memory impairment, dizziness, hypesthesia, dysgeusia, tinnitus, fatigue.
  Allergic reactions: urticaria, pruritus, toxic epidermal necrolysis, erythema multiforme, bullous rash, anaphylactic shock, angioedema.
  Others: flu-like condition, trauma, tendon rupture, joint pain, rhabdomyolysis, peripheral edema, chest pain.

  It should be borne in mind that, regardless of the age category of patients, the use of the drug Atorvastatin may develop myopathy, including muscle weakness and pain, which are accompanied by an increase in the level of creatine phosphokinase (10 or more times higher than normal). With the development of myopathy, Atorvastatin should be discontinued. The risk of this effect is increased in patients receiving cyclosporine, erythromycin, fibric acid derivatives, azole antifungals, and niacin.

  Atorvastatin should not be used in patients with known hypersensitivity to the active ingredient of the drug.
  Tablets Atorvastatin should not be administered to patients with lactose intolerance (in particular, patients with lactase deficiency, galactosemia or glucose-galactose malabsorption syndrome).
  Atorvastatin should not be prescribed to patients with severe liver disease, as well as with a persistent increase in liver transaminase activity (3 times higher than normal values).
  In pediatric practice, Atorvastatin is used only for the treatment of children over 10 years of age.
  Caution should be exercised when prescribing Atorvastatin to patients suffering from chronic alcoholism, liver disease, acute severe infections, severe electrolyte, metabolic or endocrine disorders, as well as to patients who have undergone major surgery or trauma.

  Atorvastatin should be used with caution in patients without cardiovascular disease who have had a stroke or transient ischemic attack within 6 months before starting atorvastatin therapy (atorvastatin in this case may increase the risk of hemorrhagic stroke, but taking atorvastatin reduces the overall number of strokes and cases of cardiovascular disease).
  It is recommended to avoid activities that require a high concentration of attention and speed of psychomotor reactions during the period of atorvastatin therapy.

  Atorvastatin should not be given to women during pregnancy or to women at high risk of pregnancy (particularly women of reproductive age who are not using reliable methods of contraception).
  During lactation, atorvastatin should only be taken after breastfeeding has ended.

  There is an increased risk of myopathy with the combined use of atorvastatin with cyclosporine, erythromycin, fibric acid and its derivatives, antifungal drugs of the azole group, and niacin.
  It is possible to reduce the flame concentrations of atorvastatin by 25-35% when used in combination with colestipol and antacids containing magnesium or aluminum hydroxide, but this effect has no clinical significance.
  The drug Atorvastatin slightly inhibits the activity of cytochrome P450 3A4, however, the interaction of atorvastatin with drugs that are metabolized with the participation of cytochrome P450 3A4, including antipyrine, tolbutamide, terfenadine, oral contraceptives and triazolam, has no clinical significance.
  An increase in plasma concentrations of digoxin is possible when combined with high doses of atorvastatin (80 mg atorvastatin per day). If necessary, the combined use of the drug Atorvastatin with digoxin should be monitored plasma concentrations of the latter.

  Co-administration of atorvastatin with erythromycin or clarithromycin may increase plasma concentrations of atorvastatin.
  Possible change in the pharmacokinetics of oral contraceptives containing ethinyl estradiol and norethindrone, when combined with atorvastatin.
  Drugs that inhibit cytochrome P450 3A4, when used in combination, increase plasma concentrations of unchanged atorvastatin. In addition, a similar effect can be observed while taking atorvastatin and drinking grapefruit juice (especially more than 1.2 liters of grapefruit juice per day).

  When taking excessive doses of Atorvastatin, patients may develop rhabdomyolysis and liver dysfunction.
  There is no specific antidote. When taking high doses of atorvastatin, it is recommended to perform a gastric lavage and take enterosorbent agents. If necessary, carry out symptomatic treatment.
  Carrying out hemodialysis with an overdose of atorvastatin is ineffective.

  Film-coated tablets, Atorvastatin, 10 pieces in blister packs, 3 blister packs are enclosed in a carton box.

  Atorvastatin should be stored and transported in its original packaging at temperatures between 15 and 30 degrees Celsius. Subject to the recommendations for storage, the drug Atorvastatin is suitable for 2 years after release.