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Side effects of cetirizine 20 mg: Cetirizine: antihistamine that relieves allergy symptoms

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Cetirizine: antihistamine that relieves allergy symptoms

1. About cetirizine

Cetirizine is an antihistamine medicine that helps the symptoms of allergies.

It’s used to treat:

  • hay fever
  • conjunctivitis (red, itchy eye)
  • eczema
  • hives (urticaria)
  • reactions to insect bites and stings
  • some food allergies

Cetirizine is known as a non-drowsy antihistamine. It’s much less likely to make you feel sleepy than some other antihistamines.

Cetirizine is available on prescription, but you can also buy it from pharmacies and supermarkets.

It comes as tablets, capsules and as a liquid that you swallow.

2. Key facts

  • It’s usual to take cetirizine once a day. Children aged under 12 take it twice a day.
  • Cetirizine is classed as a non-drowsy antihistamine, but some people still find it makes them feel quite sleepy.
  • Common side effects include headaches, dry mouth, feeling sick, dizziness and diarrhoea.
  • Some brands of cetirizine come as capsules. These may contain soya oil. Do not take cetirizine capsules if you are allergic to peanuts or soya.
  • Some Benadryl products do not contain cetirizine, but a different antihistamine such as acrivastine.

3. Who can and cannot take cetirizine

Most adults can take cetirizine.

Children

  • Children aged 1 and over can take cetirizine liquid if prescribed by their doctor.
  • Children aged 2 and over can take cetirizine liquid bought from pharmacies or prescribed by their doctor.
  • Children aged 6 and over can take cetirizine tablets and liquid that you buy from pharmacies and supermarkets.
  • Children aged 12 and over can take cetirizine capsules, tablets and liquid that you buy from pharmacies and supermarkets.

Who may not be able to take cetirizine

Cetirizine is not suitable for some people. To make sure it’s safe for you, tell your doctor or pharmacist if you:

  • have ever had an allergic reaction to cetirizine or any other medicine
  • have an allergy to food additives
  • have an allergy to peanuts or soya – some brands of cetirizine capsules (but not tablets) contain soya
  • have kidney failure
  • have epilepsy or another health problem that puts you at risk of having seizures or fits
  • have a condition that means you have difficulty peeing
  • are due to have an allergy test – taking cetirizine may affect the results, so you might need to stop taking it a few days before the test

4.

How and when to take cetirizine

If you or your child have been prescribed cetirizine, follow your doctor’s instructions about how and when to take it. If it is from a pharmacy or shop, follow the instructions that come with the packet.

Dosage and strength

Cetirizine comes as tablets and capsules (10mg) and as a liquid medicine (labelled either 5mg/5ml or 1mg/1ml).

The usual dose for adults is 10mg once a day.

Doses are usually lower for people with kidney problems.

Children
  • For children between 6 to 11 years of age, the usual dose is 5mg, twice a day. Try to leave 10 to 12 hours between doses. So, one first thing in the morning, and one before bedtime.
  • For children between 2 to 5 years of age, the dose is 2.5mg, twice a day.
  • For children between 1 to 2 years of age, your doctor will use their weight or age to work out the right dose.

How to take it

You can take cetirizine with or without food, but always take the tablets or capsules with a drink of water, milk or squash. Swallow them whole. Do not chew them.

Cetirizine liquid may be easier for children to take than tablets. The liquid medicine will come with a plastic syringe or spoon to give the right dose. If you do not have a syringe or spoon, ask your pharmacist for one. Do not use a kitchen teaspoon as it will not measure out the right amount.

When to take it

You may only need to take cetirizine on a day you have symptoms – for example, if you have been in contact with something that has triggered your allergy, like animal hair.

Or you may need to take it regularly to prevent symptoms – for example, to stop hay fever during spring and summer.

What if I forget to take it?

Take your forgotten dose as soon as you remember, unless it’s nearly time for your next dose. In this case, skip the missed dose and take your next dose at the usual time.

Do not take 2 doses to make up for a forgotten dose.

If you forget to give a dose to a child who is taking cetirizine twice a day, you can give the missed dose if it’s within 4 hours of when they should have had it.

If you remember more than 4 hours after, do not give the missed dose. Instead, wait until the next dose and carry on as normal.

If you often forget doses, it may help to set an alarm to remind you. You could also ask your pharmacist for advice on other ways to help you remember to take your medicine.

What if I take too much?

Cetirizine is generally very safe. Taking more than the usual dose is unlikely to harm you or your child.

If you take an extra dose, you might get some of the common side effects. If this happens or you’re concerned, contact your doctor.

5. Side effects

Like all medicines, cetirizine can cause side effects, although not everyone gets them.

Common side effects

The most common side effect of cetirizine is feeling sleepy and tired. This happens in more than 1 in 10 people. Talk to your doctor or pharmacist if this side effect bothers you or does not go away.

Other common side effects of cetirizine happen in more than 1 in 100 people.

Talk to your doctor or pharmacist if these side effects bother you or do not go away:

  • headaches
  • dry mouth
  • feeling sick (nausea)
  • feeling dizzy
  • diarrhoea
  • sore throat
  • sneezing or blocked and runny nose

Children are more likely to get diarrhoea, sneezing or a blocked and runny nose than adults.

Serious side effects

It’s rare to have a serious side effect with cetirizine.

Call your doctor straight away if you have bruising or bleeding that’s more than normal.

Serious allergic reaction

In rare cases, it’s possible to have a serious allergic reaction (anaphylaxis) to cetirizine.

Immediate action required: Call 999 now if:

  • your lips, mouth, throat or tongue suddenly become swollen
  • you’re breathing very fast or struggling to breathe (you may become very wheezy or feel like you’re choking or gasping for air)
  • your throat feels tight or you’re struggling to swallow
  • your skin, tongue or lips turn blue, grey or pale (if you have black or brown skin, this may be easier to see on the palms of your hands or soles of your feet)
  • you suddenly become very confused, drowsy or dizzy
  • someone faints and cannot be woken up
  • a child is limp, floppy or not responding like they normally do (their head may fall to the side, backwards or forwards, or they may find it difficult to lift their head or focus on your face)

You or the person who’s unwell may also have a rash that’s swollen, raised, itchy, blistered or peeling.

These can be signs of a serious allergic reaction and may need immediate treatment in hospital.

These are not all the side effects of cetirizine. For a full list, see the leaflet inside your medicines packet.

Information:

You can report any suspected side effect using the Yellow Card safety scheme.

Visit Yellow Card for further information.

6. How to cope with side effects of cetirizine

What to do about:

  • feeling sleepy and tired – try a different non-drowsy antihistamine. If this does not help, talk to your doctor.
  • headaches – make sure you rest and drink plenty of fluids. It’s best not to drink too much alcohol. Ask your pharmacist to recommend a painkiller for your headaches, but they usually go away after the first week of taking cetirizine. Talk to your doctor if your headaches last longer than a week or are severe.
  • dry mouth – chew sugar-free gum or suck sugar-free sweets.
  • feeling sick (nausea) – try taking your tablets with food. It may also help if you stick to simple meals and avoid rich or spicy food.
  • feeling dizzy – if cetirizine makes you feel dizzy when you stand up, try getting up very slowly or stay sitting down until you feel better. If you begin to feel dizzy, lie down so that you do not faint, then sit until you feel better. Do not drive, cycle or use tools or machines if you feel dizzy or a bit shaky.
  • diarrhoea – drink plenty of water or other fluids if you have diarrhoea. Speak to a pharmacist if you have signs of dehydration, such as peeing less than usual or having dark, strong-smelling pee. Do not take any other medicines to treat diarrhoea without speaking to a pharmacist or doctor.
  • sore throat – if you’re 16 and over, you can try gargling with an aspirin solution (1 soluble aspirin tablet dissolved in half a glass of water) or use a pain-relieving mouthwash such as Oraldene. If your symptoms last longer than a week, ask your pharmacist or doctor for advice. Children under 16 must not be given aspirin.
  • sneezing or blocked and runny nose – try a different non-drowsy antihistamine. If this does not help, talk to your doctor.

7. Pregnancy and breastfeeding

Cetirizine can be used in pregnancy. There is no good evidence that it causes harm to the baby. However, other antihistamines such as loratadine may be recommended as there is more information about its use in pregnancy.

Cetirizine and breastfeeding

If your doctor or health visitor says your baby is healthy, you can take cetirizine while breastfeeding.

There is some information available which shows that only very small amounts get into breast milk. Cetirizine has been used for many years while breastfeeding without side effects in babies.

If your baby is not feeding as well as usual, seems unusually sleepy, or if you have any other concerns about your baby, talk to your doctor, pharmacist, health visitor or midwife.

Non-urgent advice: Tell your doctor if you’re:

  • trying to get pregnant
  • pregnant
  • breastfeeding

Find out more about how cetirizine can affect you and your baby during pregnancy on the Best Use of Medicines in Pregnancy (BUMPS) website.

8. Cautions with other medicines

Some medicines can increase the chances of you having side effects with cetirizine.

Check with your pharmacist or doctor if you’re taking any medicine that makes you drowsy, gives you a dry mouth, or makes it difficult for you to pee. Taking cetirizine might make these side effects worse.

Mixing cetirizine with herbal remedies and supplements

There might be a problem taking some herbal remedies and supplements alongside cetirizine, especially ones that cause sleepiness, a dry mouth, or make it difficult to pee.

Important:
Medicine safety

Tell your doctor or pharmacist if you’re taking any other medicines, including herbal medicines, vitamins or supplements.

9. Common questions about cetirizine

How does cetirizine work?

Cetirizine is a type of medicine called an antihistamine. When you come into contact with something you’re allergic to, such as pollen, animal hair or fur, your body produces a chemical called histamine.

Usually histamine is a useful substance, but in an allergic reaction it causes unpleasant symptoms including itchy, watery eyes, a running or blocked nose, sneezing and skin rashes.

Cetirizine blocks the effects of histamine and reduces these symptoms.

When will I feel better?

You should start to feel better within an hour.

How long should I take cetirizine for?

It depends on why you’re taking cetirizine.

You may only need to take it for a short time or as a one-off dose.

For example, if you have a reaction to an insect bite, you may only need to take cetirizine for a day or two.

You may need to take cetirizine for longer if you’re taking it to prevent symptoms – for example, to stop hay fever when the pollen count is high.

Talk to your doctor or pharmacist if you’re unsure how long you need to take cetirizine for.

Is it safe to take cetirizine for a long time?

Cetirizine is unlikely to do you any harm if you take it for a long time.

However it’s best to take cetirizine only for as long as you need to. If you take it regularly over a long period there’s a very small chance of severe itching if you stop treatment suddenly.

If you’ve been taking cetirizine every day for a long time, talk to your doctor before stopping it.

Can I drink alcohol with it?

It’s best not to drink alcohol while you’re taking cetirizine as it can make you feel sleepy.

Is there any food or drink I need to avoid?

You can eat and drink normally while taking cetirizine.

Can I drive or ride a bike with it?

Cetirizine is classed as a non-drowsy antihistamine, but it’s still possible to feel sleepy after taking it.

If this happens to you, do not drive a car, ride a bike, use tools or machinery until you do not feel tired anymore.

It’s an offence to drive a car if your ability to drive safely is affected. It’s your responsibility to decide if it’s safe to drive. If you’re in any doubt, do not drive.

Talk to your doctor or pharmacist if you’re unsure whether it’s safe for you to drive while taking cetirizine. GOV.UK has more information on the law on drugs and driving.

What’s the difference between cetirizine and other antihistamines?

Cetirizine is known as a non-drowsy antihistamine. That’s because it’s less likely to make you feel sleepy than sedating antihistamines, such as Piriton (chlorphenamine).

Most people prefer to take a non-drowsy antihistamine instead of one that makes them drowsy. An exception is when you want the medicine to make you sleepy – for example, if you have itchy skin that’s keeping you awake.

What’s the difference between cetirizine and other non-drowsy antihistamines?

Other non-drowsy antihistamines, such as loratadine, desloratadine, fexofenadine and levocetirizine, seem to work just as well as cetirizine.

But cetirizine seems to be more likely to make you feel sleepy than loratadine, desloratadine or fexofenadine.

Can I take it with painkillers?

Yes, you can take cetirizine together with paracetamol or ibuprofen.

Can I take 2 types of antihistamine in 1 day?

Sometimes doctors recommend that people with a severe, itchy skin rash take 2 different antihistamines together for a few days.

As well as taking a non-drowsy antihistamine during the day (such as cetirizine or loratadine), your doctor may advise that you take a drowsy antihistamine at night time if the itching is making it difficult to sleep.

Do not take 2 antihistamines together unless recommended by your doctor.

Can I take cetirizine with other hay fever treatments?

Yes, it’s fine to take cetirizine together with some other hay fever treatments – for example, steroid nasal sprays (such as beclometasone (Beconase), Rhinocort Aqua and Flixonase Nasules) or eye drops.

Can I take cetirizine at higher doses than on the packet?

Your doctor may prescribe a higher dose of cetirizine (up to 4 times the usual dose) for you or your child, for a severe, itchy skin rash or swelling under the skin (angioedema).

Taking high doses of cetirizine is not suitable for everyone though. Speak to your doctor if you think cetirizine is not working for you.

Will it affect my fertility?

There’s no evidence to suggest that taking certirizine will reduce fertility in either men or women.

Speak to a pharmacist or your doctor before taking it if you’re trying to get pregnant.

Will it affect my contraception?

Cetirizine does not affect any type of contraception, including the combined pill and emergency contraception.

However, if cetirizine makes you vomit or have severe diarrhoea for more than 24 hours, your contraceptive pills may not protect you from pregnancy. Check the pill packet to find out what to do.

Read more about what to do if you’re on the pill and you’re being sick or have diarrhoea.

Can lifestyle changes relieve hay fever?

It’ll help if you do not spend too much time outside if the pollen count is high.

Tips for when you’re outside
  • Do not cut grass or walk on grass.
  • Wear wraparound sunglasses to stop pollen getting into your eyes.
  • Put Vaseline around your nostrils to help trap pollen.
  • Shower and change your clothes after you have been outside to wash off pollen.
Tips for when you’re inside
  • Keep windows and doors shut as much as possible.
  • Vacuum regularly and dust with a damp cloth.
  • Do not keep fresh flowers in the house.
  • Do not smoke or be around smoke as it makes hay fever symptoms worse.

Cetirizine Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Uses

Cetirizine is an antihistamine used to relieve allergy symptoms such as watery eyes, runny nose, itching eyes/nose, sneezing, hives, and itching. It works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction.Cetirizine does not prevent hives or prevent/treat a serious allergic reaction (such as anaphylaxis). If your doctor has prescribed epinephrine to treat allergic reactions, always carry your epinephrine injector with you. Do not use cetirizine in place of your epinephrine.

How to use Cetirizine HCL

If you are taking the over-the-counter product to self-treat, read all directions on the product package before taking this medication. If you have any questions, consult your pharmacist. If your doctor has prescribed this medication, take it as directed, usually once daily.

If you are using the chewable tablets, chew each tablet well and swallow. If you are using the rapidly-dissolving tablet, allow the tablet to dissolve on the tongue and then swallow, with or without water. If you are using the liquid form of this medication, measure the dose carefully using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.

The dosage is based on your age, medical condition, and response to treatment. Do not increase your dose or take this medication more often than directed.

Tell your doctor if your allergy symptoms do not improve, if your hives do not improve after 3 days of treatment, or if your hives last more than 6 weeks. Get medical help right away if your condition worsens or if you think you have a serious medical problem (such as a very serious allergic reaction/anaphylaxis).

Side Effects

Drowsiness, tiredness, and dry mouth may occur. Stomach pain may also occur, especially in children. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

If your doctor has prescribed this medication, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: difficulty urinating, weakness.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking cetirizine, tell your doctor or pharmacist if you are allergic to it; or to hydroxyzine; or to levocetirizine; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: difficulty urinating (such as due to an enlarged prostate), kidney disease, liver disease.

If you are using this medication to treat hives, tell your doctor right away if you have any of these other symptoms because they may be signs of a more serious condition: hives that are an unusual color, hives that look bruised or blistered, hives that do not itch.

This drug may make you drowsy. Alcohol or marijuana (cannabis) can make you more drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

Liquid products may contain sugar. Caution is advised if you have diabetes. Ask your doctor or pharmacist about using this product safely.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

This medication passes into breast milk. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Tell your doctor or pharmacist if you are taking other products that cause drowsiness such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or other antihistamines (such as chlorpheniramine, diphenhydramine).

Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.

Do not use with any other antihistamines applied to the skin (such as diphenhydramine cream, ointment, spray) because increased side effects may occur.

Cetirizine is very similar to hydroxyzine and levocetirizine. Do not use these medications while using cetirizine.

This medication may interfere with certain lab tests (such as allergy skin testing), possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug.

Does Cetirizine HCL interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe drowsiness. In children, mental/mood changes (such as restlessness, irritability) may occur before drowsiness.

Keep all medical and lab appointments.

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature away from light and moisture. Do not store in the bathroom. Different brands of this medication may have different storage needs. Check the product package for instructions on how to store your brand, or ask your pharmacist. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Images

cetirizine 10 mg tablet

Color: whiteShape: ovalImprint: 4h3

This medicine is a white, oval, film-coated, tablet imprinted with “4h3”.

cetirizine 10 mg tablet

Color: whiteShape: ovalImprint: C

This medicine is a white, oval, film-coated, tablet imprinted with “4h3”.

cetirizine 5 mg tablet

Color: whiteShape: barrelImprint: CTN 5

This medicine is a white, oval, film-coated, tablet imprinted with “4h3”.

cetirizine 1 mg/mL oral solution

Color: colorlessShape: Imprint:

This medicine is a white, oval, film-coated, tablet imprinted with “4h3”.

cetirizine 10 mg tablet

Color: whiteShape: pillowImprint: APO 10 MG

This medicine is a white, oval, film-coated, tablet imprinted with “4h3”.

cetirizine 5 mg tablet

Color: whiteShape: pillowImprint: APO 5mg

This medicine is a white, oval, film-coated, tablet imprinted with “4h3”.

cetirizine 10 mg tablet

Color: whiteShape: rectangular (rounded end)Imprint: G 4

This medicine is a white, oval, film-coated, tablet imprinted with “4h3”.

cetirizine 1 mg/mL oral solution

Color: colorlessShape: Imprint:

This medicine is a white, oval, film-coated, tablet imprinted with “4h3”.

cetirizine 1 mg/mL oral solution

Color: colorlessShape: Imprint:

This medicine is a white, oval, film-coated, tablet imprinted with “4h3”.

cetirizine 1 mg/mL oral solution

Color: colorlessShape: Imprint:

This medicine is a white, oval, film-coated, tablet imprinted with “4h3”.

cetirizine 10 mg tablet

Color: whiteShape: rectangular (rounded end)Imprint: RI52

This medicine is a white, oval, film-coated, tablet imprinted with “4h3”.

cetirizine 10 mg tablet

Color: whiteShape: roundImprint: X 36

This medicine is a white, oval, film-coated, tablet imprinted with “4h3”.

cetirizine 1 mg/mL oral solution

Color: colorlessShape: Imprint:

This medicine is a white, oval, film-coated, tablet imprinted with “4h3”.

cetirizine 10 mg tablet

Color: whiteShape: roundImprint: M C37

This medicine is a white, oval, film-coated, tablet imprinted with “4h3”.

cetirizine 10 mg tablet

Color: whiteShape: rectangular (rounded end)Imprint: S 521

This medicine is a white, oval, film-coated, tablet imprinted with “4h3”.

cetirizine 1 mg/mL oral solution

Color: colorlessShape: Imprint:

This medicine is a white, oval, film-coated, tablet imprinted with “4h3”.

cetirizine 1 mg/mL oral solution

Color: colorlessShape: Imprint:

This medicine is a white, oval, film-coated, tablet imprinted with “4h3”.

cetirizine 1 mg/mL oral solution

Color: colorlessShape: Imprint:

This medicine is a white, oval, film-coated, tablet imprinted with “4h3”.

cetirizine 10 mg chewable tablet

Color: peachShape: roundImprint: SZ 106

This medicine is a white, oval, film-coated, tablet imprinted with “4h3”.

cetirizine 5 mg chewable tablet

Color: peachShape: roundImprint: SZ 104

This medicine is a white, oval, film-coated, tablet imprinted with “4h3”.

cetirizine 1 mg/mL oral solution

Color: colorlessShape: Imprint:

This medicine is a white, oval, film-coated, tablet imprinted with “4h3”.

cetirizine 1 mg/mL oral solution

Color: Shape: Imprint:

This medicine is a white, oval, film-coated, tablet imprinted with “4h3”.

cetirizine 1 mg/mL oral solution

Color: colorlessShape: Imprint:

This medicine is a white, oval, film-coated, tablet imprinted with “4h3”.

cetirizine 10 mg tablet

Color: whiteShape: barrelImprint: CTN 10

This medicine is a white, oval, film-coated, tablet imprinted with “4h3”.

cetirizine 5 mg tablet

Color: whiteShape: roundImprint: M C35

This medicine is a white, oval, film-coated, tablet imprinted with “4h3”.

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What helps, dosage, composition, contraindications

THERE ARE CONTRAINDICATIONS. POSSIBLE SIDE EFFECTS. A SPECIALIST’S CONSULTATION IS REQUIRED. . number 31944

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Contents of the article

  • Cetirizine: composition
  • Cetirizine: what pills
  • Cetirizine: for allergies
  • Cetirizine: contraindications
  • Cetirizine: side effects
  • Cetirizine or Cetirizine: which is better
  • Cetirizine or Loratadine: which is better
  • Cetirizine or Suprastin: which is better
  • 90 013 Summary

  • Ask an expert about the topic of the article

Spring is just around the corner, which means it’s time to get ready for seasonal allergies. Along with the warming and flowering of plants, the beautiful season brings a runny nose, red eyes and constant sneezing. According to statistics, the prevalence of allergic rhinitis in Russia ranges from 10 to 24% of the population. At the same time, the disease is characterized by low appeal for help in the early stages, which leads to late diagnosis.

The pharmacist will tell you about the drug Cetirizine: introduce you to its composition, indications for use, dosages and side effects, and also compare it with analogues.

Cetirizine: composition

Cetirizine is an active ingredient and an allergy drug of the same name. Manufactured by several pharmaceutical companies under a variety of trade names:

  • Cetirizine tablets (Russia, Pakistan, Poland, Israel): Cetirizine Novex, Cetirizine Vertex, Cetrin
  • Cetirizine drops (Russia, Switzerland): Cetirizine Medisorb, Zodak, Zirtek

It is impossible to deduce a single composition of auxiliary agents, since each manufacturer uses its own formula. As a rule, the composition of the tablets includes: lactose monohydrate, microcrystalline cellulose, crospovidone, magnesium stearate and silicon dioxide. Drops consist of glycerin, propylene glycol, purified water and other components.

All products Cetirizine

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Cetirizine: what pills

Cetirizine is a second generation antihistamine. The drug helps to cope with allergies, and also facilitates its development and course. Unlike drugs of the previous generation, Cetirizine has a longer duration of action and almost does not cause drowsiness.

It is important to note how long the effect of cetirizine takes. So, the effect of the drug occurs after 20 minutes, but reaches its maximum after 1-2 hours after administration. The action persists for more than 24 hours.

Cetirizine: for allergies

As mentioned above, cetirizine is prescribed to combat an allergic reaction. According to the instructions, the indications for the use of the drug include:

  • Relief of symptoms of seasonal and year-round allergic conjunctivitis and rhinitis: itching, sneezing, nasal congestion, watery eyes and copious discharge from the nose, redness of the mucous membranes of the eyes
  • Relief of symptoms of idiopathic urticaria – skin rash, blisters and severe itching

Cetirizine: dosage

The adult dosage of Cetirizine is 10 mg, which is equivalent to 1 tablet and 20 drops once a day. The dose changes in the presence of impaired renal function.

Cetirizine for children: dosage

The dosage of cetirizine for children depends on age. A complete list can be found in the instructions for the drug. It is important to remember that tablets are used from the age of 6, and drops from 6 months. For example, for children from 6 to 12 years old, 5 mg or half a tablet is prescribed twice a day, and the dosage of Cetirizine drops for this age is 20 drops per day.

Cetirizine: contraindications

Allergy symptoms often occur during childbearing, but not all drugs are equally safe for mother and fetus. The use of cetirizine during pregnancy is not recommended. In addition, the drug is excreted in mother’s milk, so Cetirizine should not be taken while breastfeeding. Other contraindications include:

  • Hypersensitivity to drug components
  • Loss of kidney function
  • Hereditary galactose intolerance and lactase deficiency for tablets
  • Children up to 6 months (for drops), up to 6 years (for tablets)

Cetirizine and alcohol compatibility

Co-administration of cetirizine and alcohol is not recommended, as this contributes to a loss of concentration and reaction time. Also, after taking the drug, you should not engage in potentially hazardous activities.

Cetirizine side effects

  • Increased fatigue
  • Headache and dizziness
  • Anaphylactic shock
  • Skin rash and itching
  • Agitation and sleep disturbance
  • Palpitations
  • Abdominal pain
  • Diarrhea
  • Dry mouth and pharyngitis
  • Drowsiness
  • Increased activity of liver enzymes
  • Weight gain

Cetirizine or Cetirizine: which is better

Cetirizine is a direct analogue of Cetirizine with the same active ingredient. The preparations are almost identical, with a few exceptions: Cetrine is produced in India and only in the form of tablets. Therefore, when choosing a medicine, it is recommended to be guided by the doctor’s prescriptions, affordability or personal preferences in the manufacturing company.

All products Cetrin

20 reviews

Cetirizine or Loratadine: which is better

Loratadine is an antiallergic drug available in the form of tablets and syrup. Producing countries of Loratadin: Russia, Republic of Belarus, Israel and others. Similar to Cetirizine, Loratadine is related to second-generation antihistamines, that is, it acts for a longer time and does not cause a pronounced sleepy effect. Preparations differ in the following indicators:

  • The action of Cetirizine is somewhat faster: 20 minutes for Cetirizine versus 30 minutes for Loratadine
  • Loratadine tablets can be taken from 3 years of age, syrup from 2 years of age
  • Loratadine may be taken during pregnancy after a doctor’s prescription if the benefit to the mother outweighs the potential risk to the fetus
  • Loratadine has fewer contraindications but is used with caution in hepatic disorders

Thus, for children under 2 years old, there is only one possible option – Cetirizine in the form of drops. However, a better solution would be to consult a doctor.

All products Loratadin

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Cetirizine or Suprastin: which is better

Suprastin is a first-generation antihistamine that appeared in the 20th century. The drug is produced in Hungary in the form of tablets and solution for injection. Suprastin is based on a substance called Chloropyramine.

First generation drugs have a shorter duration of action and cause drowsiness and distraction. The effect after taking Suprastin appears after 15-30 minutes, but lasts only for 3-6 hours, which is justified in some situations. Nevertheless, with persistent allergies, it becomes necessary to increase the frequency of administration up to 3-4 times a day, which is not always convenient. Suprastin in the form of tablets can be used from 3 years, injections from 1 month.

The spectrum of potential side effects of Suprastin is much wider, so when choosing tablets, Cetirizine is a safe option. The final decision on the appointment of the drug should be taken by the doctor. The presence of an injection solution in Suprastin is a big plus, since it makes it possible to effectively get rid of a rapidly developing allergy.

All products Suprastin

20 reviews

Summary

  • Cetirizine is an active ingredient and an allergy drug of the same name.
  • The drug helps to cope with allergies, and also facilitates its development and course.
  • The adult dosage of cetirizine is 10 mg, which is equivalent to 1 tablet and 20 drops once a day.
  • The use of cetirizine during pregnancy is not recommended.
  • Cetrin is a direct analogue of Cetirizine with the same active ingredient.
  • Loratadine is an antiallergic drug available in the form of tablets and syrup.
  • Suprastin is a first generation antihistamine that appeared in the 20th century.

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Cetirizine-Teva film-coated tablets 10 mg: instruction, price, analogues | film-coated tablets Teva Ukraine

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  • Pharmacological properties
  • Readings
  • Contraindications
  • Interaction with other medicinal products and other forms of interaction
  • Dosage and Administration
  • Overdose
  • Adverse reactions
  • Expiry date
  • Storage conditions
  • Diagnosis
  • Recommended alternatives
  • Trade names

CETIRIZIN-TEVA

Composition:

active substance: cetirizine;

1 tablet contains cetirizine dihydrochloride 10 mg;

excipients: lactose monohydrate, microcrystalline cellulose, anhydrous colloidal silicon dioxide, magnesium stearate, Opadry Y-1-7000 (titanium dioxide (E 171), hydroxypropyl methylcellulose, polyethylene glycol (macrogol 400)

Drug natural form

Film-coated tablets

Basic physical and chemical properties: round, biconvex, film-coated tablets, from white to off-white, with a separation line on one side.

Pharmacotherapeutic group

Antihistamines for systemic use. ATC code R06A E07.

Pharmacological properties

Pharmacodynamics.

Cetirizine, a human metabolite of hydroxyzine, is a potent selective peripheral h2 receptor antagonist. In in vitro receptor binding studies, no affinity was observed for receptors other than h2 receptors. In addition to the antagonistic effect on h2 receptors, cetirizine has an antiallergic effect: at a dosage of 10 mg 1 or 2 times a day, the drug inhibits the late phase of involvement in the process of inflammatory cells, especially eosinophils, in the skin and conjunctiva of persons who were injected with the antigen, and at a dose of 30 mg / day inhibits the influx of eosinophils in the bronchoalveolar fluid during the late phase of bronchial constriction caused by inhalation of allergens in patients with asthma. In addition, cetirizine inhibits the late phase inflammatory response induced in patients with chronic urticaria by intradermal administration of kallikrein. It also reduces the adhesion of molecules such as ICAM-1 and VCAM-1, which are markers of allergic inflammation.

Pharmacokinetics.

Cetirizine does not undergo extensive first pass metabolism. About 2/3 of the dose is excreted unchanged in the urine. The volume of absorption of cetirizine did not decrease when taken with food, although the rate of absorption decreased. The volume of bioavailability is similar when prescribing cetirizine in the form of a solution, capsules or tablets.

Clinical characteristics

Indications

Symptomatic treatment of seasonal and persistent allergic rhinitis (symptoms such as rhinorrhea, nasal itching, sneezing), as well as non-nasal symptoms associated with conjunctivitis. Itching and urticaria of various types, including chronic idiopathic urticaria.

Contraindications

Hypersensitivity to cetirizine or to other components of the drug, as well as to hydroxyzine and to any piperazine derivatives in history.

Patients with severe renal impairment with creatinine clearance less than 10 ml/min.

Interaction with other medicinal products and other types of interactions

Based on the pharmacokinetics, pharmacodynamics and tolerance indices of cetirizine, the occurrence of any type of interaction with this antihistamine is unlikely. In particular, drug interaction studies have shown neither pharmacodynamic nor any significant pharmacokinetic interaction when administered concomitantly with pseudoephedrine or theophylline (400 mg/day).

In studies of the use of cetirizine with cimetidine, glipizide, diazepam and pseudoephedrine, there was no evidence of adverse pharmacodynamic interactions.

In studies of the use of cetirizine with antipyrine, azithromycin, erythromycin, ketoconazole, theophylline and pseudoephedrine, there was no evidence of adverse clinical interactions. In addition, the simultaneous use of cetirizine with macrolides or ketoconazole did not lead to clinically significant changes in the ECG.

There is no evidence of an increase in the effect of sedatives when using cetirizine at therapeutic doses. However, sedatives should be avoided while taking cetirizine.

The rate of absorption of cetirizine does not decrease with food, although the rate of absorption decreases.

Application features.

When taken at therapeutic doses, no clinically significant interactions with alcohol were noted (with a blood alcohol level of 0.5 g / l). However, this drug should be used with caution while drinking alcohol.

Use with caution in patients with epilepsy who may experience seizures.

Taking antihistamines can affect the results of skin tests to determine allergies, therefore, before conducting them, you need to withstand the period of withdrawal of such drugs from the body (3 days).

Do not use this medicine in patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption.

Caution should be exercised when using the drug in patients with a tendency to urinary retention (for example, with lesions of the spinal cord, prostatic hyperplasia), cetirizine may increase the risk of urinary retention.

Itching and/or urticaria may occur after discontinuation of cetirizine, even if these symptoms were not present prior to treatment. In some cases, the symptoms may be intense and it may be necessary to restart treatment after stopping it. These symptoms usually disappear after treatment is resumed.

Use during pregnancy or lactation.

Pregnancy

Insufficient data on the use of the drug during pregnancy. Animal studies do not indicate direct or indirect harmful effects on pregnancy, embryonic/fetal development, childbirth or postnatal development. It should be prescribed to pregnant women in cases where the benefit outweighs the potential risk to the fetus.

Breast-feeding period

Cetirizine passes into breast milk at concentrations of 25-90% of plasma concentrations, depending on the time interval after drug administration. Therefore, women who are breastfeeding should use cetirizine with caution.

The ability to influence the reaction rate when driving vehicles or operating other mechanisms.

Objective determination of the ability to drive vehicles, work with mechanisms and the degree of drowsiness did not show any clinically significant effect when using the drug at the recommended dose of 10 mg.

Patients who drive motor vehicles, are involved in potentially hazardous work or maintain mechanized equipment, should not exceed the recommended doses and should take into account the reaction of their own body to the drug.

In sensitive patients, concomitant use of the drug with alcohol or other CNS depressants may cause additional deterioration in attention during potentially hazardous work.

Dosage and administration

Take by mouth with 1 glass of liquid. Eating does not affect the amount of absorption of cetirizine, although it somewhat slows down this process.

Adults and children over 6 years: 10 mg (1 tablet) once daily. You can use the drug at an initial dose of 5 mg, if it is sufficient to control symptoms.

The course of treatment is determined by the doctor, depends on the course and duration of the disease and the individual sensitivity of the patient.

Elderly patients.

There is no need to reduce the dose for elderly patients in the absence of impaired renal function.

Patients with impaired renal function (moderate to severe).

Dosage should be individualized, depending on the state of renal function. Refer to Table 1 and adjust the dose according to the information given. To use Table 1, it is necessary to determine the patient’s creatinine clearance (CC) in ml/min. The value of CC (ml / min) can be determined from serum creatinine (mg / dl) using the formula:

CC = [140 – age (in years)] × body weight (kg) / 72 × serum creatinine (mg / dL) ( × 0.85 for women).

Table 1

Dosage adjustment for adult patients with impaired renal function

Group Creatinine clearance (ml/min) Dosage and frequency
Normal function ≥ 80 10 mg once daily
Mild impairment 50–79 10 mg once daily
Moderate 30-49 5 mg once daily
Severe < 30 5 mg every 2 days
End stage kidney disease – dialysis patients < 10 Contraindicated

For children with impaired renal function, the dose is adjusted individually, depending on the patient’s CC value and body weight.

Patients with impaired liver function.

There is no need for dose adjustment in violation of liver function only.

Patients with impaired liver and kidney function.

Dosage adjustment is recommended (see section “Patients with impaired renal function” above).

Children.

The drug is used for children over 6 years of age.

Overdose

Symptoms.

Symptoms observed after an overdose of cetirizine are mainly related to effects on the central nervous system or to effects that may indicate an anticholinergic effect. Side effects that have been reported after taking a dose exceeding at least 5 times the recommended daily dose include: confusion, diarrhea, dizziness, fatigue, headache, malaise, mydriasis, itching, restlessness, sedation, drowsiness, stupor, tachycardia, tremor, urinary retention.

Treatment.

No specific antidote for cetirizine is known. In case of overdose, symptomatic and supportive therapy is recommended. Gastric lavage should be carried out as soon as possible after taking the drug. Cetirizine is inefficiently excreted during dialysis.

Adverse reactions

Clinical studies have shown that cetirizine, when used at the recommended doses, causes minor CNS side effects, including drowsiness, fatigue, dizziness and headache. Paradoxical CNS stimulation has been reported in some cases.

Although cetirizine is a selective peripheral h2 receptor antagonist and has almost no anticholinergic effect, isolated cases of difficulty urinating, disturbance of accommodation of the eye, and dry mouth have been reported.

Cases of abnormal liver function have been reported, characterized by elevated levels of liver enzymes, accompanied by elevated levels of bilirubin. Usually the condition returned to normal after discontinuation of the drug.

Clinical studies

There is safety data for the use of cetirizine in more than 3200 subjects who participated in double-blind controlled studies comparing cetirizine with placebo or other antihistamines at the recommended dose (10 mg cetirizine daily).

Summarizing these data, placebo-controlled studies reported the occurrence of side effects with the use of cetirizine 10 mg with an incidence of 1.0% or more (table 2).

Table 2
Side effects

(WHO terminology for side effects)

Cetirizine 10 mg

(n = 3260)

Placebo

(n = 3061)

Whole body – general disorders

Fatigue

1.63% 0.95%
From the side of the central and peripheral nervous system

Dizziness

Headache

1.10%

7.42%

0.98%

8.07%

From the gastrointestinal tract

Stomach pain

Dry mouth

Nausea

0.98%

2.09%

1.07%

1.08%

0.82%

1.14%

From the side of the psyche

Drowsiness

9.63% 5.00%
Respiratory

Pharyngitis

1. 29% 1.34%

Although, statistically speaking, drowsiness occurred more frequently than in the placebo group, in most cases it was mild or moderate. As in other studies, the results of objective studies confirmed that the recommended daily dose does not adversely affect daily activities in healthy subjects.

Table 3

Adverse reactions with an incidence of 1% or more in children aged 6 months to 12 years in placebo-controlled clinical trials

Side effects

(WHO terminology for side effects)

Cetirizine

(n = 1656)

Placebo

(n = 1294)

From the gastrointestinal tract

Diarrhea

1.0% 0.6%
From the side of the psyche

Drowsiness

1.8% 1.4%
Respiratory

Rhinitis

1.4% 1.1%
Whole body – general disorders

Fatigue

1. 0% 0.3%

Post-launch follow-up

In addition to the side effects reported in clinical trials and listed above, the following side effects have been reported post-market.

Post-marketing adverse events reported according to organ system classification (MedDRA system) and frequency.

Frequency data are defined as follows: infrequent (≥ 1/1000 and <1/100), rare (≥ 1/10000 and <1/1000), very rare (<1/10000), frequency unknown (frequency cannot be determined based on existing data).

Blood and lymphatic system disorders

Very rare: thrombocytopenia.

From the immune system

Rare: hypersensitivity.

Very rare: anaphylactic shock.

From the side of metabolism and nutrition

Frequency unknown: increased appetite.

From the side of the psyche

Uncommon: agitation.

Rare: aggressiveness, confusion, depression, hallucinations, insomnia.

Very rare: nervous tic.

Frequency unknown: suicidal thoughts.

From the nervous system

Uncommon: paresthesia.

Rare: convulsions.

Very rare: dysgeusia, syncope, tremor, dystonia, dyskinesia.

Frequency unknown: amnesia, memory impairment.

On the part of the organs of vision

Very rare: disturbance of accommodation of the eye, blurred vision, involuntary movements of the eyeball.

From the hearing organs

Frequency unknown: vertigo.

From the side of the heart

Rare: tachycardia.

Gastrointestinal

Uncommon: diarrhea.

From the side of the hepatobiliary system

Rarely: abnormal liver function (increased levels of transaminases, alkaline phosphatase, GGTP and bilirubin).

Skin and subcutaneous tissue disorders

Uncommon: itching, rash.

Rare: urticaria.

Very rare: angioedema, drug-resistant erythema.

Frequency unknown: acute generalized exanthematous pustulosis.

From the urinary system

Very rare: dysuria, enuresis.

Frequency unknown: urinary retention.

General disorders and disorders related to the method of application of the drug

Uncommon: asthenia, malaise.

Rare: edema.

Laboratory tests

Rare: weight gain.

Description of selected adverse reactions

Itching (severe itching) and/or urticaria have been reported after discontinuation of cetirizine.

Shelf life

3 years.

Storage conditions

No special storage conditions. Keep out of the reach of children.

Packaging

7 tablets in a blister, 1 blister in a box of 10 tablets in a blister, 1 or 2 or 3 or 5 blisters in a box.

Dispensing category

Without a prescription.

Producer

Merkle GmbH.

Location of the manufacturer and address of the place of business

Ludwig-Merkle-Straße 3, 89143 Blaubeuren, Germany.

Allergic urticaria ICD L50.0
Allergic rhinitis ICD J30.4

Allergic-dominated asthma

ICD J45.0
Children’s papular acrodermatitis (Gianotti-Crosti syndrome) ICD L44.4
Other urticaria ICD L50.8
Other myositis ICD M60.8
Other acute sinusitis ICD J01.8
Other seborrheic dermatitis ICD L21.8
Idiopathic urticaria ICD L50.

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