What are the primary uses of Effexor. How does Effexor work in the brain. What are the most common side effects of Effexor. How should Effexor be taken for optimal results. Are there any serious risks associated with Effexor use. How does Effexor compare to other antidepressants. What precautions should be taken when using Effexor.

Understanding Effexor: A Powerful Antidepressant Medication

Effexor, known generically as venlafaxine, is a widely prescribed antidepressant medication belonging to the class of drugs called Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs). This medication plays a crucial role in treating various mental health conditions, primarily depression. Its unique mechanism of action sets it apart from other antidepressants, making it an important option for individuals struggling with mood disorders.

How does Effexor work in the brain. Effexor functions by helping to restore the balance of two key neurotransmitters in the brain: serotonin and norepinephrine. By inhibiting the reuptake of these chemicals, Effexor increases their availability in the brain, which can lead to improvements in mood, energy levels, and overall well-being.

Primary Uses and Benefits of Effexor

Effexor is primarily prescribed for the treatment of depression. However, its benefits extend beyond just alleviating depressive symptoms. Here are some of the key uses and benefits of Effexor:

• Treating major depressive disorder
• Managing generalized anxiety disorder
• Helping with social anxiety disorder
• Addressing panic disorder
• Potentially aiding in the treatment of obsessive-compulsive disorder (OCD)

Can Effexor improve overall quality of life. Many patients report significant improvements in their mood, energy levels, and ability to engage in daily activities after starting Effexor. The medication may help restore interest in activities that were previously enjoyable, enhance concentration, and promote better sleep patterns.

Proper Usage and Dosage Guidelines for Effexor

To ensure the best results and minimize potential side effects, it’s crucial to take Effexor exactly as prescribed by your healthcare provider. Here are some important guidelines for using Effexor:

1. Take Effexor orally, usually 2 to 3 times daily with food.
2. Follow your doctor’s instructions regarding dosage carefully.
3. Start with a low dose, which may be gradually increased based on your response to treatment.
4. Take the medication regularly at the same times each day for optimal benefit.
5. Do not stop taking Effexor abruptly without consulting your doctor.

Why is it important to take Effexor with food. Taking Effexor with food can help reduce the likelihood of experiencing nausea, a common side effect of the medication. Additionally, consuming food with Effexor may enhance its absorption, potentially improving its effectiveness.

Common Side Effects and Management Strategies

Like all medications, Effexor can cause side effects. While not everyone experiences these, it’s important to be aware of potential adverse reactions. Common side effects of Effexor include:

• Nausea
• Drowsiness
• Dizziness
• Dry mouth
• Constipation
• Loss of appetite
• Blurred vision
• Nervousness
• Trouble sleeping
• Unusual sweating
• Yawning

How can one manage the side effects of Effexor. Many side effects are mild and may diminish over time as your body adjusts to the medication. To manage side effects, consider the following strategies:

• Take the medication with food to reduce nausea
• Stay hydrated to combat dry mouth and constipation
• Engage in regular exercise to improve sleep and reduce nervousness
• Practice good sleep hygiene to address insomnia
• Use artificial tears for blurred vision

If side effects persist or worsen, it’s crucial to consult your healthcare provider. They may adjust your dosage or recommend additional strategies to manage side effects effectively.

Serious Risks and Precautions Associated with Effexor Use

While Effexor can be highly beneficial for many individuals, it’s essential to be aware of potential serious risks and take necessary precautions. Some of the more serious concerns associated with Effexor use include:

Increased Risk of Suicidal Thoughts

A small number of people, especially those under 25, may experience an increase in suicidal thoughts or behaviors when taking antidepressants like Effexor. It’s crucial to monitor for any worsening of depression or unusual changes in behavior, particularly when starting the medication or adjusting the dose.

Serotonin Syndrome

In rare cases, Effexor can lead to a potentially life-threatening condition called serotonin syndrome, especially when combined with other medications that increase serotonin levels. Symptoms may include agitation, hallucinations, rapid heart rate, fever, muscle stiffness, and seizures.

Blood Pressure Changes

Effexor may cause an increase in blood pressure. Regular monitoring of blood pressure is recommended, especially during the initial stages of treatment or when the dose is adjusted.

Withdrawal Symptoms

Abruptly stopping Effexor can lead to withdrawal symptoms, including dizziness, nausea, headache, and flu-like symptoms. Always consult your doctor before discontinuing or changing your dosage.

What should you do if you experience serious side effects while taking Effexor. If you notice any severe or concerning symptoms, such as significant mood changes, unusual bleeding, seizures, or signs of serotonin syndrome, seek immediate medical attention. It’s crucial to maintain open communication with your healthcare provider throughout your treatment with Effexor.

Interactions and Contraindications: What to Watch Out For

Effexor can interact with various medications and substances, potentially altering its effectiveness or increasing the risk of side effects. It’s essential to inform your healthcare provider about all medications, supplements, and herbal products you’re taking. Some notable interactions include:

• Monoamine Oxidase Inhibitors (MAOIs): Combining Effexor with MAOIs can lead to dangerous interactions. A gap of at least 14 days is required between stopping an MAOI and starting Effexor.
• Other Antidepressants: Combining Effexor with other antidepressants, especially SSRIs, can increase the risk of serotonin syndrome.
• Blood Thinners: Effexor may interact with blood thinners like warfarin, potentially increasing the risk of bleeding.
• NSAIDs: Non-steroidal anti-inflammatory drugs may increase the risk of bleeding when taken with Effexor.
• Alcohol: Consuming alcohol while taking Effexor can increase the risk of side effects and may worsen depression symptoms.

Are there any specific dietary restrictions while taking Effexor. While there are no strict dietary restrictions associated with Effexor, it’s generally advisable to maintain a balanced diet and limit alcohol consumption. Some patients report that caffeine can exacerbate certain side effects, so monitoring your caffeine intake may be beneficial.

Comparing Effexor to Other Antidepressants: Pros and Cons

Effexor belongs to the SNRI class of antidepressants, which sets it apart from other commonly prescribed antidepressants like Selective Serotonin Reuptake Inhibitors (SSRIs). Understanding how Effexor compares to other antidepressants can help patients and healthcare providers make informed decisions about treatment options.

Effexor vs. SSRIs

SSRIs, such as fluoxetine (Prozac) and sertraline (Zoloft), are often considered first-line treatments for depression. However, Effexor may offer some advantages:

• Dual action on serotonin and norepinephrine, which may be more effective for some patients
• Potentially more effective in treating severe depression
• May be beneficial for patients who haven’t responded well to SSRIs

However, Effexor may also have some drawbacks compared to SSRIs:

• Potentially more side effects, especially at higher doses
• Higher risk of withdrawal symptoms if discontinued abruptly
• May cause more significant increases in blood pressure

Effexor vs. Other SNRIs

Other SNRIs include duloxetine (Cymbalta) and desvenlafaxine (Pristiq). While these medications work similarly, there may be slight differences in their side effect profiles and effectiveness for individual patients.

How does one determine which antidepressant is best. The choice of antidepressant depends on various factors, including the specific symptoms of depression, potential side effects, other medical conditions, and individual patient preferences. It often requires a process of trial and error to find the most effective medication with the least side effects for each individual.

Special Considerations for Specific Patient Groups

While Effexor can be an effective treatment for many individuals with depression, certain patient groups may require special consideration when using this medication:

Pregnant and Breastfeeding Women

The use of Effexor during pregnancy and breastfeeding should be carefully evaluated. Some studies suggest a potential risk of birth defects, particularly in the first trimester. However, untreated depression during pregnancy also carries risks. Breastfeeding while taking Effexor is generally considered safe, but infants should be monitored for potential side effects.

Elderly Patients

Older adults may be more sensitive to the side effects of Effexor, particularly dizziness and risk of falls. Lower starting doses and careful monitoring may be necessary for this population.

Children and Adolescents

Effexor is not approved for use in children and adolescents under 18 years of age. The risk of suicidal thoughts and behaviors may be higher in this age group.

Patients with Liver or Kidney Disease

Individuals with liver or kidney impairment may require dose adjustments and closer monitoring when taking Effexor.

What precautions should be taken when prescribing Effexor to these special patient groups. Healthcare providers should conduct a thorough risk-benefit analysis, consider alternative treatments when appropriate, and implement close monitoring strategies. Regular check-ins and open communication between patients and healthcare providers are crucial for ensuring safe and effective treatment.

Long-term Effects and Considerations of Effexor Use

While Effexor can be an effective long-term treatment for depression and anxiety disorders, it’s important to consider the potential long-term effects of its use. Some considerations include:

Metabolic Changes

Long-term use of Effexor may lead to changes in metabolism, potentially affecting weight and blood sugar levels. Regular monitoring of weight and metabolic parameters is advisable.

Sexual Side Effects

Some patients experience persistent sexual side effects, such as decreased libido or difficulty achieving orgasm. These effects may continue even after discontinuing the medication in rare cases.

Bone Health

There is some evidence suggesting that long-term use of SNRIs like Effexor may be associated with an increased risk of bone fractures, particularly in older adults.

Cognitive Effects

While Effexor often improves cognitive function in depressed patients, some individuals report difficulties with memory or concentration, especially at higher doses.

How can patients and healthcare providers balance the long-term benefits and risks of Effexor use. Regular follow-ups, periodic reassessment of the need for continued treatment, and open discussions about any emerging concerns are crucial. In some cases, strategies such as dose reduction or switching to alternative treatments may be considered if long-term side effects become problematic.

In conclusion, Effexor (venlafaxine) is a potent antidepressant that can significantly improve the lives of individuals struggling with depression and other mood disorders. While it offers numerous benefits, it’s crucial to be aware of potential side effects, interactions, and long-term considerations. By working closely with healthcare providers, maintaining open communication, and following prescribed guidelines, patients can maximize the benefits of Effexor while minimizing potential risks. As with any medication, the decision to use Effexor should be made on an individual basis, taking into account the specific needs, medical history, and circumstances of each patient.

Effexor Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Warnings:

Antidepressant medications are used to treat a variety of conditions, including depression and other mental/mood disorders. These medications can help prevent suicidal thoughts/attempts and provide other important benefits. However, a small number of people (especially people younger than 25) who take antidepressants for any condition may experience worsening depression, other mental/mood symptoms, or suicidal thoughts/attempts. It is very important to talk with the doctor about the risks and benefits of antidepressant medication (especially for people younger than 25), even if treatment is not for a mental/mood condition.

Tell the doctor right away if you notice worsening depression/other psychiatric conditions, unusual behavior changes (including possible suicidal thoughts/attempts), or other mental/mood changes (including new/worsening anxiety, panic attacks, trouble sleeping, irritability, hostile/angry feelings, impulsive actions, severe restlessness, very rapid speech). Be especially watchful for these symptoms when a new antidepressant is started or when the dose is changed.

Warnings:

Antidepressant medications are used to treat a variety of conditions, including depression and other mental/mood disorders. These medications can help prevent suicidal thoughts/attempts and provide other important benefits. However, a small number of people (especially people younger than 25) who take antidepressants for any condition may experience worsening depression, other mental/mood symptoms, or suicidal thoughts/attempts. It is very important to talk with the doctor about the risks and benefits of antidepressant medication (especially for people younger than 25), even if treatment is not for a mental/mood condition.

Tell the doctor right away if you notice worsening depression/other psychiatric conditions, unusual behavior changes (including possible suicidal thoughts/attempts), or other mental/mood changes (including new/worsening anxiety, panic attacks, trouble sleeping, irritability, hostile/angry feelings, impulsive actions, severe restlessness, very rapid speech). Be especially watchful for these symptoms when a new antidepressant is started or when the dose is changed.

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Uses

Venlafaxine is used to treat depression. It may improve your mood and energy level, and may help restore your interest in daily living. Venlafaxine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). It works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.

How to use Effexor Tablet

Read the Medication Guide provided by your pharmacist before you start using venlafaxine and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth as directed by your doctor, usually 2 to 3 times daily with food.

The dosage is based on your medical condition and response to treatment. To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor’s instructions carefully. Take this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.

Keep taking this medication even if you feel well. Do not stop taking this medication without consulting your doctor. Some conditions may become worse when this drug is suddenly stopped. Also, you may experience symptoms such as confusion, mood swings, blurred vision, headache, tiredness, sleep changes, and brief feelings similar to electric shock. Your dose may need to be gradually decreased to reduce side effects. Report any new or worsening symptoms right away.

It may take several weeks to feel the benefit of this medication. Tell your doctor if your condition lasts or gets worse.

Side Effects

See also Warning section.

Nausea, drowsiness, dizziness, dry mouth, constipation, loss of appetite, blurred vision, nervousness, trouble sleeping, unusual sweating, or yawning may occur. If any of these effects last or get worse, tell your doctor promptly.

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

This medication may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high.

Tell your doctor right away if you have any serious side effects, including: easy bleeding/bruising, decreased interest in sex, changes in sexual ability, muscle cramps/weakness, shaking (tremor).

Get medical help right away if you have any very serious side effects, including: cough that doesn’t go away, shortness of breath, chest pain, severe/pounding headache, black stools, vomit that looks like coffee grounds, eye pain/swelling/redness, widened pupils, vision changes (such as seeing rainbows around lights at night), seizure.

This medication may increase serotonin and rarely cause a very serious condition called serotonin syndrome/toxicity. The risk increases if you are also taking other drugs that increase serotonin, so tell your doctor or pharmacist of all the drugs you take (see Drug Interactions section). Get medical help right away if you develop some of the following symptoms: fast heartbeat, hallucinations, loss of coordination, severe dizziness, severe nausea/vomiting/diarrhea, twitching muscles, unexplained fever, unusual agitation/restlessness.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking venlafaxine, tell your doctor or pharmacist if you are allergic to it; or to desvenlafaxine; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: bleeding problems, personal or family history of glaucoma (angle-closure type), high blood pressure, heart problems (such as heart failure, previous heart attack), high cholesterol, kidney disease, liver disease, seizure disorder, thyroid disease.

This drug may make you dizzy or drowsy or blur your vision. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Older adults may be more sensitive to the side effects of this drug, especially bleeding and dizziness when standing. Older adults may also be more likely to develop a type of salt imbalance (hyponatremia), especially if they are taking “water pills” (diuretics). Dizziness and salt imbalance can increase the risk of falling.

Children may be more sensitive to the side effects of the drug, especially loss of appetite and weight loss. Monitor weight and height in children who are taking this drug.

During pregnancy, this medication should be used only when clearly needed. It may harm an unborn baby. Also, babies born to mothers who have used this drug during the last 3 months of pregnancy may rarely develop withdrawal symptoms such as feeding/breathing difficulties, seizures, muscle stiffness, or constant crying. If you notice any of these symptoms in your newborn, tell the doctor promptly.

Since untreated mental/mood problems (such as depression, anxiety, panic attacks) can be a serious condition, do not stop taking this medication unless directed by your doctor. If you are planning pregnancy, become pregnant, or think you may be pregnant, immediately discuss the benefits and risks of using this medication during pregnancy with your doctor.

This drug passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Some products that may interact with this drug are: other drugs that can cause bleeding/bruising (including antiplatelet drugs such as clopidogrel, NSAIDs such as ibuprofen/naproxen, “blood thinners” such as dabigatran/warfarin).

Aspirin can increase the risk of bleeding when used with this medication. However, if your doctor has directed you to take low-dose aspirin for heart attack or stroke prevention (usually 81-162 milligrams a day), you should continue taking it unless your doctor instructs you otherwise. Ask your doctor or pharmacist for more details.

Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Avoid taking MAO inhibitors (isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before and at least 7 days after treatment with this medication. Ask your doctor when to start or stop taking this medication.

The risk of serotonin syndrome/toxicity increases if you are also taking other drugs that increase serotonin. Examples include street drugs such as MDMA/”ecstasy,” St. John’s wort, certain antidepressants (including SSRIs such as fluoxetine/paroxetine, other SNRIs such as duloxetine/milnacipran), tryptophan, among others. The risk of serotonin syndrome/toxicity may be more likely when you start or increase the dose of these drugs.

Tell your doctor or pharmacist if you are taking other products that cause drowsiness such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or antihistamines (such as cetirizine, diphenhydramine).

Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.

Venlafaxine is very similar to desvenlafaxine. Do not take medications containing desvenlafaxine while using venlafaxine.

This medication may interfere with certain lab tests (including urine tests for amphetamines), possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug.

Does Effexor Tablet interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe drowsiness, seizures, fast/irregular heartbeat.

Do not share this medication with others.

Lab and/or medical tests (such as blood pressure, cholesterol) should be done while you are taking this medication. Keep all medical and lab appointments. Consult your doctor for more details.

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Effexor Health Risks, Side Effects and Complications

What is Effexor?

Effexor is the name brand for the generic medication venlafaxine hydrochloride and is a serotonin-norepinephrine reuptake inhibitor (SNRI) antidepressant drug approved for the treatment of major depression. A controlled release form, Effexor XR is also approved to treat generalized anxiety, panic disorder, and social phobia.

How Does Effexor Work?

Effexor is an SNRI and is different than an SSRI. SNRIs work by regulating serotonin and norepinephrine reabsorption. SNRIs work to treat depression and other mental disorders by increasing the activity of neurotransmitters, or chemical messengers, serotonin and norepinephrine, in certain areas of the brain. Serotonin acts to regulate sleep and mood and may help provide the satiety or “satisfaction” sensation. Norepinephrine is made from dopamine and plays a key role in alertness, arousal, and attention. Effexor increases the levels of both serotonin and norepinephrine in the brain.

Other members of the SNRI class of medications include Cymbalta (duloxetine), Pristiq (desvenlafaxine), and Savella (milnacipran).

What Company Manufactures Effexor?

Effexor is the brand name for venlafaxine hydrochloride and was originally manufactured by Wyeth. Pfizer acquired Wyeth in 2009 and continues to manufacture Effexor. Effexor was the first SNRI antidepressant and became available in 1993. By 2007, Effexor became the sixth most popularly-prescribed drug in its class with more than 17 million prescriptions in the United States. Effexor as a “fast-release” medication is no longer manufactured by Pfizer but may still be available generically and requires multiple doses to be taken each day.

In 2007, Effexor’s then-manufacturer, Wyeth was given a warning by the U.S. Food and Drug Administration (FDA) regarding misleading advertising which had minimized the risks of Effexor and overstated its effectiveness.

Is Effexor FDA Approved?

The U.S. Food and Drug Administration (FDA) approved Effexor in 1993 to treat depression in adults. In 1997, a controlled release form, Effexor XR, was approved to treat other conditions in adults such as anxiety, panic disorders, and social phobia. Effexor is not approved for use in children.

What Is Effexor Prescribed to Treat?

Effexor is prescribed by doctors to treat conditions it is approved to treat as well as conditions for which it is not approved. Effexor is only approved by the FDA to treat major depression.

Symptoms of major depression include:

• Loss of interest in normal activities
• Feelings of guilt or worthlessness
• Excessive crying
• Lack of energy
• Loss of concentration
• Changes in appetite
• Changes in sleep patterns
• Suicidal thoughts and tendencies

Effexor XR is approved by the FDA for major depression as well as anxiety, panic disorders, and social phobia.

What Is Anxiety?

Anxiety is a natural response to stress. It may cause feelings of nervousness or anxiousness. Anxiety can be helpful in some situations, and it may alert to danger or help a person pay attention. Anxiety in general differs from anxiety disorders, which are characterized by excessive worry, fear, or anxiety which are not proportionate to the situation and affect a person’s ability to function like normal.

What Are Panic Disorders?

Panic disorders are one variety of anxiety disorders. People with panic disorder experience unanticipated and recurrent episodes of heightened fear that are coupled with physical symptoms such as chest pain, shortness of breath, dizziness, heart palpitations, or abdominal discomfort or distress. Episodes caused by panic disorder are not induced by an obvious stressor.  

What Is Social Phobia?

Social phobia, or social anxiety disorder, is another variety of anxiety disorder. A person who has social anxiety disorder experiences extreme anxiety, self-consciousness, and embarrassment because they fear others are scrutinizing them or negatively judging them. People with social anxiety disorder may avoid various situations where they may be the center of attention or fear embarrassment if they do something or speak out.

Is Effexor Prescribed to Treat Other Conditions?

Effexor is sometimes prescribed “off-label” to treat other conditions than those for which it is approved. When a medication is prescribed off-label, that means that it does not have FDA approval to treat that condition. Federal law allows for medications to be prescribed for non-approved conditions, but pharmaceutical companies are prohibited from marketing medications to treat those non-approved conditions.

Conditions for which Effexor has been prescribed off-label include:

• Attention deficit/hyperactivity disorder in both adults and children
• Obsessive-compulsive disorder (OCD)
• Posttraumatic stress disorder (PTSD)
• Premenstrual dysphoric disorder (PMDD)

Some physicians have prescribed Effexor to treat pain caused by severe migraines, diabetic neuropathy, and hot flashes. Before prescribing Effexor for any of these off-label uses, doctors should justify their reasoning and discuss it with their patients.

Does Effexor Cause Side Effects?

Effexor, like most medications, causes side effects in some patients. Most of these side effects are mild and will go away on their own with time. However, some patients may experience severe side effects and should seek medical attention right away. These severe side effects are dangerous and may become life-threatening in some cases.

Mild side effects caused by Effexor include:

• Dry mouth
• Dizziness
• Nausea
• Headache
• Blurred vision
• Increased sweating
• Nervousness or insomnia
• Drowsiness or fatigue
• Constipation
• Strange dreams
• Appetite and weight change
• Decreased libido, sex drive, and difficulty achieving orgasm

Can Effexor Cause Severe Side Effects?

Effexor can cause severe side effects. These side effects should be reported to a healthcare professional immediately.

Severe side effects caused by Effexor may include:

• Trouble breathing or tightness in the chest
• Memory
• Hallucination
• Seizures
• Fever, nausea, or vomiting
• Increased heart rate or blood pressure
• Hostility, agitation, aggression
• Suicidal thoughts or behavior
• Sudden changes in moods or behavior
• Anxiety or panic attacks

Effexor may cause side effects that are significant and may be life-threatening. These side effects have been the basis of lawsuits filed against the manufacturer. These are:

• Birth defects
• Serotonin syndrome
• Withdrawal or discontinuation syndrome

Is Effexor Safe to Take When Pregnant?

Effexor use has been associated with a number of birth defects when the drug is taken during pregnancy. The FDA has given venlafaxine a pregnancy category of C which indicates that Effexor has caused harm to animals during testing but has not been fully tested in humans.

The Canadian Medical Association Journal published a study in 2010 on venlafaxine, the active ingredient in Effexor. The study indicated that the risk of miscarriage was doubled in women who took the drug during pregnancy.

Effexor may cause “non-teratogenic effects” in newborns. These effects are not birth defects, but they may include complications that require lengthened hospital stays, respiratory support, and the use of a feeding tube after delivery.

Serious effects in newborns noted with Effexor may include:

• Respiratory distress
• Cyanosis
• Apnea
• Seizures
• Temperature instability
• Difficulty feeding
• Constant crying
• Irritability
• Vomiting
• Hypotonia
• Hypoglycemia
• Jitteriness
• Tremor
• Hypertonia
• Hyperreflexia

Is Effexor Linked to Birth Defects?

Pregnant or nursing mothers face serious risks. Effexor carries the potential risk of birth defects and may be linked to serious complications in some pregnancies. These include:

• Persistent pulmonary hypertension of the newborn (PPHN)
• Respiratory distress
• Heart defects and malformations
• Physical defects such as cleft lip and palate
• Anencephaly – the absence of parts of the brain and skull
• Craniosynostosis – causes abnormal skull and brain growth
• Omphalocele – an abdominal defect that causes organs to protrude from the belly button

Is It Safe to Take Effexor While Breastfeeding?

After birth, nursing infants may still develop side effects related to Effexor use from their mothers.

Newborns may develop symptoms such as:

• Irregular appetite or difficulties feeding
• Heart defects
• Growth or development defects
• Jitteriness or shaking
• Seizures
• Consistent or abnormally frequent crying

Does Taking Effexor Cause Serotonin Syndrome?

Though it most commonly occurs in SSRI-type antidepressants, SNRI medications such as Effexor may also result in excessive serotonin buildup in the brain. It is more likely if the SNRI is taken with other medications that also affect serotonin including treatments for migraine, cough suppressants, and certain herbal remedies.

Symptoms may include:

• Sudden spikes in blood pressure or heart rate
• Higher than normal body temperature
• Unexpected muscle contractions
• Changes in mental status
• Loss of consciousness

Symptoms of serotonin syndrome should be treated as an emergency. In some cases, serotonin syndrome may be life-threatening. All medications should be discussed with a physician to avoid drug interactions.

Does Stopping Effexor Cause Withdrawal or Discontinuation Syndrome?

Experts recommend that patients consult a physician before stopping Effexor use. Stopping too soon or abruptly can lead to withdrawal symptoms or discontinuation syndrome.

Effexor withdrawal symptoms may include:

• Loss of coordination
• Stomach cramps
• Severe headaches/migraines
• Extreme sleepiness
• Fatigue

Have Lawsuits Been Filed Because of Effexor?

After its acquisition of Wyeth, Pfizer assumed responsibility for Effexor liability including lawsuits filed due to medical injury. Pfizer has faced multiple lawsuits after Effexor was used during pregnancy and may have caused birth defects. Women have said that they would not have used Effexor during pregnancy if they had been properly warned of the risk. The company may also face lawsuits for other side effects or medical injuries. People or loved ones of those who experienced harm due to Effexor should seek legal assistance.

What Types of Lawsuits Have Been Filed Regarding Effexor?

There are two main types of lawsuits that have been filed regarding potential claims patients and their loved ones may have against the manufacturer of Effexor. These two lawsuit types are:

1. Product liability
2. Wrongful death

Both lawsuit types can result in monetary awards to the Plaintiff. They also help to raise awareness about a dangerous product.

What Are Product Liability Lawsuits Involving Effexor?

A medication manufacturer is charged with ensuring its medications are not unreasonably dangerous to patients and are safe for patients to take. Plaintiffs who have filed Effexor lawsuits allege that the manufacturer did not provide adequate warnings about the possible severe risks of taking Effexor. The plaintiffs argue that the injuries they or their loved ones sustained would not have resulted had they been properly warned about the risks associated with taking Effexor.

What Are Wrongful Death Lawsuits Involving Effexor?

A wrongful death lawsuit can be brought by certain immediate family members of a deceased person against the individual or company that caused the loved one’s death. Those family members or close loved ones who may sue vary depending on state laws. Wrongful death lawsuits have been brought against the manufacturer of Effexor in situations where a baby died because of a birth defect linked to Effexor and in situations where it is alleged that Effexor led to suicide.

What Effexor Lawsuit Settlements Have There Been?

As of 2016, all federal lawsuits involving Effexor were dismissed but left with the possibility of being refiled. Effexor patients who believe that Effexor has caused harm may be eligible to receive a settlement from Wyeth and should seek legal advice.

How Do I Find an Effexor Attorney?

Choosing an attorney can be intimidating. It is important to find an attorney who is knowledgeable about the subject matter. Seeger Weiss, LLP specializes in cases involving Effexor and will provide a free consultation.

Notwithstanding claims relating to this product, the drug/medical device remains approved by the U.S. FDA. 

Immunotherapy for breast cancer

The advent of immunotherapy for the treatment of breast cancer has made it possible to use the resources of the body to fight the tumor. While traditional chemotherapy drugs attack all the cells of the body, immunotherapy teaches the cells of the immune system to see the “hidden” tumor, remember it and fight it on their own.

Immunotherapy for breast cancer is a new method of treatment. In targeted therapy, drugs attack “targets” responsible for growth and development in a particular tumor. Immune preparations include their own immunity in the fight against a tumor that has escaped from immune surveillance.

Information for men

Unfortunately, men are not immune from breast (breast) cancer. This happens much less frequently, about 1% of the time. Poor education leads to the fact that men go to the doctor with an already advanced tumor. The methods of treatment are the same as for women, so the article will be useful for both sexes.

Approaches to the treatment of breast cancer

In the first stages of the tumor process, surgical treatment and radiation therapy are used. The tumor is removed as soon as possible. Drug therapy here acts as an auxiliary. It helps to reduce the volume of the tumor, prevents metastasis. In the later stages, the presence of metastases, relapses, drug therapy comes to the fore. The arsenal of doctors, once consisting only of toxic chemotherapeutic drugs (cytostatics), has been replenished with targeted drugs. If earlier all cells were attacked, then modern drugs are aimed only at specific “targets”. Targeted drugs are aimed at attacking targets in the tumor to stop growth and development. Immunotherapy for cancer is aimed at helping one’s own immunity.

The work of antitumor immunity

The immune system protects us. He, like a universal army, knows how to fight both with alien agents (viruses, bacteria), and with “traitors” (cells of his own body that have ceased to be normal). “Traitors” cease to perform the functions of normal cells, growth and development are out of control. It is important to stop such cells.

Army of Immunity

The word immunity is understood not as a couple of identical cells, but as a complex system. It has its own laws and roles. Some cells are soldiers (effectors). They hunt for strangers and “traitors”, their task is to destroy the target upon detection. Other antigen-presenting cells, compare scammers. They, having previously encountered danger, remember it (more precisely, its proteins on the surface) and show it to an elite detachment of soldiers. Then this squad will receive information about the appearance of the stranger and permission to eliminate it.

Individual cells act as officers. They decide who to work more actively, who to share, and so on.

The immune system stops seeing the tumor

Traitor cells do their best not to be detected. Cells understand who is in front of them by antigens – molecules on the surface. Based on this marker, the soldiers decide whether to kill the cell or not. By disguising itself, the tumor may not show its antigens to patrol soldiers. It is more profitable for her to get lost among normal cells, continue to use the resources of the body and not be attacked by the immune system.

Sometimes the tumor uses the same antigens that are in the tissues of the body. The immune system normally does not react on itself, therefore it does not attack the mimicking tumor.

The army of immunity is not unlimited. If there are too many tumor cells, the tumor will continue to grow.

It is not enough to notice the tumor, it is important to be able to get close to it. Sometimes mutated cells have a special environment that protects the tumor and reassures the soldiers that the tissue does not need to be touched.

How does immunotherapy work?

Knowing about these processes, we can help the immune system cope with its task. This can be done in various ways, in the article we will consider only those principles that are used in breast immunotherapy.

Immune checkpoint inhibitors

The work of soldiers – T-lymphocytes – is to kill cells that are dangerous to the body. On the surfaces of immune cells there are PD-1 receptors (programmed cell death 1, cell death receptors). Some cells secrete PD-L1 and PD-L2 proteins (eng. Programmed death-ligand 1 and 2, programmed cell death ligands PD-L1 and 2). A ligand is comparable to a key. As soon as this ligand interacts with the receptor, the immune cell ceases to “see and understand” that it should attack this cell. Normally, this is necessary for, for example, the course of pregnancy, so that the immune system does not work too actively. The tumor cell takes advantage of this and escapes. It begins to synthesize such a ligand, “turning off” T-lymphocytes.

How these drugs work

Medicines called checkpoint inhibitors help keep immune cells from shutting down. Some can close the PD-1 receptor itself, others can block the PD-L1 and 2 ligands. Immune cells get the opportunity to see and attack the tumor again.

PD1 blocker immunotherapy for breast cancer uses, for example, pembrolizumab (Keytruda). Of the PD-L1 blockers, for example, atezolizumab (Tecentriq) is used.

Lock block

Soldiers’ T-lymphocytes have receptors, “turning on” which blocks the work of the cell. Anti-CTLA4 (cytotoxic T-lymphocyte-associated protein 4, cytotoxic T-lymphocyte glycoprotein 4) drugs help prevent blocking of the immune system and maintain its activity. Ipilimumab (Yervoy) belongs to this group of drugs. It has shown itself to be excellent in the treatment of melanoma, while its effectiveness in breast cancer is still being studied.

What are drugs?

Once a special immune (plasma) cell has been taught to produce special antibodies, they are cloned. Preparations from this group are called monoclonal antibodies.

It should be noted drugs, for example, Trastuzumab (Herceptin), Sacytuzumab govitecan (Trodelvi). They are also monoclonal antibodies, but they work as a targeted drug against tumor growth and development.

Teamwork

Immunotherapy for breast cancer has been shown to be excellent when multiple drugs are combined with each other and/or chemotherapy and targeted therapy. For example, in some cases, the use of atezolizumab in combination with the chemotherapy drug nab-paclitaxel (Abraxan) is recommended. Combinations are necessary to achieve a greater effect in each specific situation, although they may be more toxic.

Benefits of immunotherapy

Conventional chemotherapy drugs attack all dividing cells, causing damage to the body. Preparations for immunotherapy are aimed at changing the immune response, which avoids toxic effects. Immunity itself begins to fight against the tumor.

The use of immunotherapy

Such a serious intervention is resorted to when surgery and radiology fail to cope with the process, as well as when metastases, relapses of the disease are detected.

Necessary tests

Before starting therapy, check the condition of the body. They look not only for clinical and biochemical blood tests, but also for hormones. Since drugs work with the immune system, it is important not to miss the presence of a pronounced autoimmune disease. In these conditions, one’s own immunity works too actively and attacks itself.

Molecular Genetic Testing for Breast Cancer Immunotherapy

Breast Cancer Immunotherapy works with a specific tumor subtype, so it is important to identify it. After testing, the doctor understands whether it is necessary to prescribe drugs of this group, which ones, in what dosage. Without objective data, it will be like firing a cannon at flying pigeons – expensive, difficult, toxic and useless.

Need help? Fill out an application on the website, we will contact you as soon as possible and answer all your questions about conducting an extended genetic study of the tumor.

Apply for a consultation

Finding the point of application of the drug

When prescribing a PD-L1 inhibitor drug to tumor cells, the doctor must be convinced of the effectiveness of the future treatment. An immunohistochemical method for studying a tumor tissue sample allows you to find PD-L1 on cells, determine their number and activity. These proteins are not present in every tumor, so treatment of a breast tumor with immunotherapy is not suitable for all patients.

Side effects

In the case of breast cancer immunotherapy, it is important to notify the doctor in time about how you feel. The drug is administered intravenously, the process is controlled by the attending physician. However, the treatment lasts for many weeks, some effects may appear delayed. An overactive immune system can trigger autoimmune reactions. It is necessary to immediately report them to the doctor to correct the condition.

Side effects include:

• Skin rash, redness;
• Weakness, fever, body pain, flu-like;
• Nausea, vomiting, headache, diarrhoea;
• Development of a number of autoimmune conditions – eg thyroiditis, hepatitis.

Contraindications

Since drugs affect the immune system, therapy is not used in active autoimmune disease. Also refrain from therapy during pregnancy and lactation. Do not use therapy for serious diseases of the liver and kidneys.

References

1. García-Aranda, Marilina, and Maximino Redondo. “Immunotherapy: A Challenge of Breast Cancer Treatment.” Cancers vol. 11.12 1822. 20 Nov. 2019, doi:10.3390/cancers11121822
2. |Kyte, JA et al. “ICON: a randomized phase IIb study evaluating immunogenic chemotherapy combined with ipilimumab and nivolumab in patients with metastatic hormone receptor positive breast cancer. ” Journal of translational medicine vol. 18.1 269. 3 Jul. 2020, doi:10.1186/s12967-020-02421-w
3. Materials published by the National Cancer Institute
4. Tsarev I.L., Melerzanov A.V. REVIEW OF APPROACHES TO IMMUNOTHERAPY IN ONCOLOGY. Research and Practical Medicine Journal. 2017;4(3):51-65. (In Russ.)

How do people feel after being vaccinated against coronavirus?

Posted 27 April 2021, 09:42

Published 27 April 2021, 09:42

Modified 1 September 2022, 03:04

Updated 1 September 2022, 03:04 90 003

April 27, 2021, 09:42

Photo: Mediaholding1Mi

Side effects of the coronavirus vaccine. Patient reviews of the coronavirus vaccine. Reviews of doctors about the vaccine against coronavirus.

What are the side effects of the coronavirus vaccine

Healthy people who have no contraindications to vaccination are unlikely to experience serious side effects. The low likelihood of side effects was identified by scientists during vaccine trials. However, if a person belongs to a certain “risk group”, then the chance of developing side effects increases.

Those who have been ill and who have a large amount of IgG antibodies in their bodies are under attack. If such a person is given a vaccine, then a cytokine storm can occur in his body, the result of which can be an inflammatory process and death. That is why before vaccination it is necessary to take a test and determine the presence of antibodies in the body.

Immunologist Ksenia Bocharova says that most acute reactions are related to a reaction to one specific component used in any vaccine. However, due to the use of modern technologies in the manufacture of drugs, negative reactions occur once in a million. The expert says that delayed reactions are much more common – fever, temperature decrease, local enlargement of lymph nodes or excessive soreness.

People with medical conditions. In some cases, the ban on immunization is temporary. So, if you get ARVI, then after recovery, you need to wait two weeks, after which you can be vaccinated. In the presence of severe allergies, it is impossible to predict how the immune system will react to the components of the vaccine, so the vaccine should be refrained from.

Patients with medical contraindications should also refuse vaccination. Doctors advise those who have been ill with acute respiratory infections not to be vaccinated for several weeks. In addition, the vaccination and its compatibility with the disease should be discussed with your doctor or therapist.

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Patient reviews of the coronavirus vaccine

General practitioners working with patients who have had coronavirus believe that Russians, in the majority, consider vaccination a necessary measure to combat the epidemic. Cardiologist, endocrinologist Aleksey Zhito notes that people met the news of widespread vaccination with some enthusiasm, and a queue of people who want to protect themselves from the disease is lining up for vaccination. The doctor emphasizes that his patients turn to him every day for advice and clarify whether they can be vaccinated. However, some patients perceive vaccination very cautiously.

Dr. Gito says that educational work helps with such people. They need to explain that several stages of clinical trials have already been completed and that the drug is safe to use. Vaccines frequently used in Russia – EpiVacCorona and Gam-COVID-Vac – have proved to be positive and are recommended by the world’s leading medical experts as a remedy that protects against infection itself and also facilitates the course of the disease.

Of course, the coronavirus vaccine will have side effects, unfortunately, this is how medicine works and there is no getting around it. In most cases, patients report a flu-like condition – aches, fever, lack of appetite and malaise. In order to reduce the risk of developing side effectors, doctors conduct a conversation with the patient and find out from him a predisposition to certain specific conditions, as well as allergies. In addition, if a person has been in contact with a patient with a coronavirus patient, then he must pass a coronavirus test and check the results to avoid negative consequences. By the way, the discomfort after vaccination does not last more than three days, so this condition can be endured.

Coronavirus Vaccine Testimonials from Doctors

The world’s medical community is unanimous in saying that vaccination is currently the only way to beat the pandemic and bring humanity back to normal. Experts recommend that those who have been vaccinated drink more fluids in order to reduce the stress of the body from the vaccine and reduce the severity of side effects. He also advises to limit the time spent in crowded places, not to overcool or overheat. Of course, it is required to comply with the mask and glove modes.

Experts advise patients who feel unwell to immediately contact their local doctors, especially for people who suffer from chronic diseases.

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Popular Questions and Answers

How long after vaccination can one not be afraid of the disease?

The specialists who developed the Sputnik V vaccine say that thanks to the two-stage vaccination, the antibodies in the blood will protect the carrier for two years after the administration of the drug. But today it is still impossible to say exactly how long the vaccine will work, because both the disease itself and the cure for it are new to the modern world.

Do you get a document when you get vaccinated?

Every vaccinated Russian receives a vaccination certificate. The document contains the personal data of the person, the date of introduction of the vaccine and the name of the drug. This document will greatly facilitate the life of those who are going abroad or traveling around the country.

How long does it take for the side effects of the coronavirus vaccine to appear?

Side effects from the introduction of the vaccine into the body may appear on the third, fifth, seventh, tenth and fourteenth days after the administration of the drug. However, doctors do not exclude that they can also appear immediately after the administration of the drug, then the person will be helped right in the vaccination room, and the reaction itself will be considered an acute post-vaccination reaction.

Experts explain that side effects usually develop within the first day after the injection. Much less often – a reaction to the drug within one or even several days. However, there are separate cases already described when the reaction occurred at a later period. In case of deterioration of health, a person should consult a doctor to get help and normalize his health.

In addition, experts never forget about the possibility of an anaphylactic reaction to the drug, so vaccination is carried out in an office equipped with a first aid kit.

How dangerous are the side effects of the coronavirus vaccine?

Doctors believe that this is still an unanswered question. Vaccines are absolutely new and the solutions that their developers use today were still unknown to mankind yesterday. Too little time has passed since the start of widespread vaccination, which means that there is not yet enough data to study. However, the first results show that there is nothing to be afraid of, now vaccines do not have really dangerous side effects and are relatively easy to tolerate.