Excedrin Side Effects | Healthfully

Excedrin (acetaminophen, aspirin and caffeine) is an over-the-counter medication indicated for the alleviation of painful symptoms associated with headache or body pain. There are eight different formulations of Excedrin available as of 2010: Excedrin Extra Strength, Extra Strength Excedrin Express Gels, Excedrin Migraine, Excedrin Menstrual Complete, Excedrin Tension Headache, Excedrin Back and Body, Excedrin PM and Excedrin Sinus Headache. Side effects associated with Excedrin vary slightly based upon the formulation used 1. For further information, review the instructional information provided in the Excedrin packaging materials.

Is This an Emergency?

If you are experiencing serious medical symptoms, seek emergency treatment immediately.

Stomach Upset

The most common side effect associated with Excedrin use is stomach upset. After taking a dose of Excedrin, you can develop symptoms of stomach pain, nausea or vomiting. Certain people can also notice bowel habit changes, such as diarrhea or constipation. Such side effects can cause additional symptoms of abdominal cramping or bloating. You may also experience an abnormal burning sensation within your stomach, chest or throat (heartburn), which can be unpleasant or cause a decrease in your appetite. Eating a small snack or meal before taking a dose of Excedrin may limit the occurrence of stomach-related side effects in some people 1. Contact your doctor immediately if you develop chest pain or tightness or if you notice blood within your stools.

• The most common side effect associated with Excedrin use is stomach upset.
• You may also experience an abnormal burning sensation within your stomach, chest or throat (heartburn), which can be unpleasant or cause a decrease in your appetite.

Difficulty Sleeping

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Treatment with Excedrin can cause you to experience difficulty sleeping as a side effect of this medication, explain health professionals at Drugs. com, an informational peer-reviewed website that provides consumer data on currently marketed drug products 1. Excedrin contains caffeine–a stimulant that can cause increased energy or wakefulness in people who take this substance. You may notice that you have difficulty falling asleep or staying asleep (insomnia) after taking a dose of Excedrin. Other people may experience excessive drowsiness or fatigue. After you determine how your body responds to this medication you can choose an appropriate time to take Excedrin to limit problematic consequences of sleep-related side effects 1.

Nervousness

While taking Excedrin, you can experience abnormal sensations of nervousness, restlessness or anxiety. These side effects can be accompanied by stomach upset, drowsiness or insomnia in certain people. Such sensations are temporary and will subside as the effects of this medication wear off.

Headache

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Excedrin can cause headaches. Headache symptoms associated with Excedrin use are typically mild and can occur within any region of your head. If you experience dizziness or blurred vision in addition to a headache while taking Excedrin, contact your doctor immediately for further evaluation and care.

Acetaminophen/Aspirin/Caffeine, Oral – Tufts Medical Center Community Care

What are other names for this medicine?

Type of medicine: analgesic (painkiller)

Generic and brand names: acetaminophen/caffeine/aspirin, oral; Excedrin Extra Strength; Excedrin Migraine; Goody’s Extra Strength; (There may be other brand names for this medicine.)

What is this medicine used for?

This medicine is taken by mouth to relieve pain and reduce fever.

This medicine may be used to treat other conditions as determined by your healthcare provider.

What should my healthcare provider know before I take this medicine?

To avoid the risk of taking an overdose, tell your provider or pharmacist about all of the other medicines you take. This includes nonprescription products.

Many prescription and nonprescription medicines for pain, headache, and sinus congestion contain acetaminophen. Read the labels of nonprescription products to find out which may contain acetaminophen. If you cannot tell if you are taking more than the recommended dosage per day, ask your healthcare provider and pharmacist to review all of your medicines.

Tell your healthcare provider if you have ever had an allergic reaction to any medicine. Check with your healthcare provider before taking this medicine if you have:

• Asthma
• Bleeding problems
• Diabetes
• Gout
• High blood pressure
• Stomach problems such as heartburn, stomach pain or ulcers
• Liver or kidney disease

Females of childbearing age: Talk with your healthcare provider if you are pregnant or plan to become pregnant. It is not known whether this medicine will harm an unborn baby. Do not breast-feed while taking this medicine without your healthcare provider’s approval.

Aspirin should not be used during the last 3 months of pregnancy unless your healthcare provider approves because it may cause problems in the unborn baby or complications during delivery.

How do I use it?

Take this medicine exactly as your healthcare provider prescribes. Do not take more of it or take it longer than directed. Taking too much may cause liver damage. If you purchased this medicine without a prescription, follow the directions on the package. Read all of the precautions and warnings printed on the package.

Check with your healthcare provider before using this medicine in children under age 12.

Take the medicine with a full glass of water. You may take this medicine with or without food. Taking it with meals may lessen the chance the drug will upset your stomach.

What if I overdose?

If you or anyone else has intentionally taken too much of this medicine, call 911 or go to the emergency room right away. If you pass out, have seizures, weakness or confusion, or have trouble breathing, call 911. If you think that you or anyone else may have taken too much of this medicine, call the poison control center. Do this even if there are no signs of discomfort or poisoning. The poison control center number is 800-222-1222.

Symptoms of an acute overdose may include: ringing in the ears, headache, dizziness, confusion, fever, nausea, vomiting, diarrhea, stomach pain, tremors, sweating, seizures, confusion, irregular heartbeat, dark urine, yellowing of the skin or eyes, coma.

What should I watch out for?

This medicine may cause severe liver damage if:

• An adult takes more than 3000-4000 mg in 24 hours
• A child takes more than 5 doses in 24 hours
• You take this medicine with other drugs that contain acetaminophen
• An adult has 3 or more alcoholic drinks every day while using this product

Aspirin can cause Reye’s syndrome in children and teens with viral infections such as the flu or chickenpox. Ask your healthcare provider before giving this medicine to children with flu symptoms.

This medicine contains caffeine. The recommended dose of this medicine contains about as much caffeine as a cup of coffee. Limit the use of other medicines, foods, or drinks that contain caffeine while taking this product. Too much caffeine may cause nervousness, irritability, sleeplessness, and a fast heartbeat.

Acetaminophen may cause severe skin reactions. Contact your healthcare provider if you have blisters, a rash, or skin reddening while taking this medicine.

Contact your healthcare provider if you take this medicine for fever and it gets worse or does not improve in 3 days. If you take this medicine for pain and it does not improve in 10 days, contact your healthcare provider.

Alcohol may increase the chance of liver damage by this medicine. Do not drink alcohol while taking this medicine. Ask your healthcare provider about this.

If you need emergency care, surgery, or dental work, tell the healthcare provider or dentist you are taking this medicine.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help): Allergic reaction (hives; itching; rash; trouble breathing; tightness in your chest; swelling of your lips, tongue, and throat).

Serious (report these to your healthcare provider right away): Yellowish eyes or skin; rash; hives; itching; bloody or cloudy urine; trouble urinating; fainting; weakness; sore throat; fever; unusual bleeding or bruising; red skin, blisters, or a rash; dark urine; light-colored bowel movements; severe stomach pain; ringing in the ears or hearing loss; severe nausea or vomiting.

Other: Heartburn, nervousness.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

• Antacids (take this medicine 2 hours before or 2 hours after you take an antacid)
• Cholestyramine (Questran) (Take this medicine 1 hour after or 4 hours before taking other medicines.)
• Cough and cold medicines such as phenylephrine and pseudoephedrine (Sudafed, Neo-Synephrine)
• Diabetes medicines such as glimepiride (Amaryl), glipizide (Glucotrol, Glucotrol XL), glyburide (DiaBeta, Glynase PresTab), insulin, metformin (Glucophage), nateglinide (Starlix), pioglitazone (Actos), repaglinide (Prandin), and rosiglitazone (Avandia)
• Medicines to treat or prevent blood clots such as abciximab (ReoPro), apixaban (Eliquis), argatroban, bivalirudin (Angiomax), clopidogrel (Plavix), dabigatran (Pradaxa), dipyridamole (Persantine), eptifibatide (Integrilin), lepirudin (Refludan), prasugrel (Effient), rivaroxaban (Xarelto), ticagrelor (Brilinta), tirofiban (Aggrastat), and warfarin (Coumadin)
• Methotrexate (Otrexup, Rasuvo, Rheumatrex, Trexall)
• Natural remedies such as cat’s claw, dong quai, evening primrose, feverfew, garlic, ginger, ginseng, ginkgo, green tea, horse chestnut, and red clover
• NSAIDS such as celecoxib (Celebrex), diclofenac (Voltaren, Cataflam), ibuprofen (Motrin, Motrin IB, Advil), indomethacin (Indocin), ketoprofen, ketorolac, meloxicam (Mobic), nabumetone (Relafen), naproxen (Naprosyn, Anaprox, Aleve, Naprelan), oxaprozin (Daypro), piroxicam (Feldene), and sulindac (Clinoril)
• Other medicines that contain salicylates such as Alka Seltzer and Pepto Bismol
• Probenecid (Benemid)
• MAO inhibitors such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam), and tranylcypromine (Parnate) (Do not take this medicine and an MAO inhibitor within 14 days of each other. )
• Stimulants such as amphetamine/dextroamphetamine, caffeine (coffee, cola, tea), diet pills, dexmethylphenidate (Focalin), dextroamphetamine (Dexedrine), lisdexamfetamine (Vyvanse), methamphetamine (Desoxyn), and methylphenidate (Concerta, Metadate CD, Methylin, Ritalin)
• Valproic acid (Depakote)

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

How should I store this medicine?

Store this medicine at room temperature. Keep the container tightly closed. Protect it from heat, high humidity, and bright light.

This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.

Medication Advisor 2015.1 published by RelayHealth.
Last modified: 2015-01-30
Last reviewed: 2015-01-30

This content is reviewed periodically and is subject to change as new health information becomes available. The information is intended to inform and educate and is not a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional.

Copyright ©1986-2015 McKesson Corporation and/or one of its subsidiaries. All rights reserved.

Excedrin Migraine vs Extra Strength: Difference & Comparison

Migraine is a medical condition in which the sufferer has a headache that usually affects one side of the head and causes extreme pain or worsening pain.

Health Quiz

Test your knowledge of health related topics

1 / 10

What is the best way to keep your mouth healthy?

Brush twice a day

Floss daily

Regular use of mouthwash

All of the above

2 / 10

What is the best way to prevent the spread of germs?

Coughing into your arm

Coughing into your sleeve

Frequent use of hand sanitizer

Not covering your mouth when coughing

3 / 10

What is the main cause of a stroke?

High blood pressure

Smoking

Lack of physical activity

Stress

4 / 10

What is the main function of the lymphatic system in the body?

To regulate blood pressure

To fight infections

To transport nutrients

To remove waste products

5 / 10

What is the best way to maintain a healthy weight?

Counting calories

Eat smaller meals

Regular exercise

All of the above

6 / 10

Which exercise is best for general health?

Running

Kettlebell lifting

Yoga

Aerobics

7 / 10

The thick, oily, dark liquid that forms when tobacco is burned is called ___________.

Tar

Nicotine

carbon

Coal

8 / 10

What is the main cause of hypertension (high blood pressure)?

Genetics

Improper diet and lifestyle

Chronic stress

All of the above

9 / 10

Which vitamin helps strengthen bones and teeth?

Vitamin A

Vitamin C

Vitamin D supplements

Vitamin E

10 / 10

What is the leading cause of death worldwide?

cancer

Heart disease

Stroke

Traffic accidents

your score

This is usually associated with nausea, diarrhea and excessive visual and auditory reactivity. Migraine flares can last from minutes to weeks, and the suffering can be severe enough to prevent someone from doing their daily activities.

To get relief from this, Excedrin Migraine and Extra Strength are on the market,

Key Findings

1. Excedrin Migraine is designed specifically for migraine while Excedrin Extra Strength is designed to relieve various types of pain.
2. Both drugs contain acetaminophen, aspirin, and caffeine, but Excedrin Migraine has a different FDA-approved dosage for migraine relief.
3. Users may take higher doses of Excedrin Extra Strength for general pain relief, but must follow the recommended dosage of Excedrin Migraine to avoid possible side effects.

The difference between Excedrin Migraine and Extra Strength is that Excedrin Migraine contains ingredients in the formula that are not in Extra Strength. Three ingredients: caffeine, acetaminophen, and aspirin. Three ingredients work great for migraines and thus, this makes Excedrin Migraine different from Extra Strength.

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Excedrin Migraine is said to be very effective. A survey report of various patients with migraine showed that Excedrin Migraine can eliminate 100% of the effect of migraine after a dose.

With that said, Excedrin is reported to have the side effects of a slight increase in heart rate.

The dosage of Extra Strength is a bit light. Up to 4 tablets can be consumed in one day. But such a dose can make a person weak or even cause nausea.

Although Extra Strength contains several ingredients, it does not contain the 3 main ingredients that have good anti-migraine properties.

Three ingredients: caffeine, acetaminophen, and aspirin. Extra Strength is best for mild migraines.

Comparison parameters	Excedrin Migraine	Extra Strength
Date of entry into the market.	It was released to the market in 1998.	It was released to the market in 1960.
dosage	The maximum intake of this is 2 times a day.	Maximum intake of this 4 times a day.
Ingredients:	Caffeine is present in the formula along with acetaminophen, aspirin.	Free from acetaminophen, aspirin and caffeine.
Migraine types	It is best for severe headaches as it is more powerful.	It is suitable for mild headaches.
Side effect	Excedrin has reported a slight increase in heart rate in some patients.	No side effects of increased heart rate reported.

What is Excedrin for migraine?

Excedrin Migraine was released to the market in 1998 after Excedrin received approval from the Food and Drug Administration to release it as a commercial product.

Excedrin Migraine is said to be very effective. A survey report of various patients with migraine showed that Excedrin Migraine can eliminate 100% of the effect of migraine after a dose.

Excedrin has been reported to have side effects of a slight increase in heart rate, but with time and low drug intake, some other additional side effects appear, such as kidney and liver damage.

Excedrin Migraine is made up of three different ingredients that work very well for migraines. The three ingredients are acetaminophen, aspirin, and caffeine.

Caffeine has a long history as a migraine remedy, so the caffeine in Excedrin Migraine enhances the effectiveness of the product.

However, very few users may also report stomach problems after using Excedrin Migraine. The dosage of Excedrin is such that only 2 of them can be consumed in one day.

If you continue taking the drug for more than a week, you may experience signs of side effects.

Extra Strength is the first launch of Excedrin. It was launched on the market in 1960. It is one of the oldest on the market.

Extra Strength was one of the oldest products with multiple ingredients. Extra Strength can cure over 50% of migraine pain, but cannot eliminate 100% of the pain.

The dosage of Extra Strength is a bit light. Up to 4 tablets can be consumed in one day. But such a dose can make a person weak or even cause nausea.

Although Extra Strength contains several ingredients, it does not contain the 3 main ingredients that have good anti-migraine properties.

Three ingredients – caffeine, acetaminophen and aspirin. Extra Strength is best for mild migraine pain. There have been no reports of immediate side effects from Extra Strength such as increased heart rate.

The only possible explanation for the high dose limit would be that people with long-term headaches would actually take medication at any time and at any dose, minimizing the effect of the medication.

Main differences between Excedrin Migraine and Extra Strength

1. Excedrin Migraine was released to the market in 1998 and Extra Strength was released to the market in 1960.
2. The maximum intake of Excedrin Migraine is 2 times a day, while the maximum intake of Extra Strength is 4 times a day.
3. Excedrin has reported an increase in heart rate in some patients, while side effects of increased heart rate for Extra Strength have not been reported.
4. Excedrin Migraine is best for severe headaches because it is more powerful, while Extra Strength is good for mild headaches.
5. Caffeine is present in the Excedrin Migraine formula along with acetaminophen and aspirin, while acetaminophen, aspirin and caffeine are not present in the Extra Strength formula.

Recommendations

1. https://www.theneighborhoodacademy.org/editoruploads/files/Kamiya_Coles_-_Caffeine_in_Headache_Medicine.pdf
2. https://www.uspharmacist.com/article/ migraine-its-recognition-and- treatment?utm_source=TrendMD&utm_medium=cpc&utm_campaign=US_Pharmacist_TrendMD_1

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“Medications for migraine” – articles on the site Vapteke.ru

Headache (migraine) is a disease of a neurological nature, which is characterized by episodic or regular bouts of unbearable intense pain in the left or right side of the head (in rare cases, the whole head hurts). Attacks are accompanied by nausea, vomiting, dizziness, exhausting and tiring. In such cases, effective migraine medications can not be dispensed with.

Medicines for migraine

Medicines for headache can be divided into 3 groups:

• Symptomatic drugs relieve pain, dizziness, help fight nausea and other symptoms.

• Preventive agents make it possible to avoid repetitions (relapses) of headache attacks in the future.

• Painkillers eliminate directly the headache attack.

Treatment of migraine with drugs should be complex, since taking only symptomatic drugs gives only a temporary relief effect.

Symptomatic remedies

The task of symptomatic remedies is to remove nausea, dizziness, weakness that accompany headaches and migraine attacks. Medicines of this group are available in the form of tablets and suppositories:

• Compazine is a neuroleptic drug (inhibits the functions of the central nervous system), which helps to alleviate the condition, removes nausea and stops vomiting.

• Thorazine is a strong sedative drug that depresses the central nervous system, has a hypnotic effect when the dosage is increased.

• Phenergan is a migraine medicine that has a pronounced antiemetic, sedative and hypnotic effect on the body.

Painkillers

Medicines in this group are broad-spectrum analgesics, which include analgesics or non-steroidal anti-inflammatory substances. They help reduce swelling that compresses the nerve endings, resulting in pain disappears. Among these drugs can be identified:

• Amigrenin is available in the form of tablets and nasal spray, contains the active substance sumatriptan, which affects the smooth muscles of the cerebral vessels, depresses the activity of the trigeminal nerve, and promotes vasoconstriction of the carotid arteries. The drug relieves pain, relieves nausea. Amigrenin begins to act half an hour after ingestion.

• Excedrin in the form of tablets is a combined migraine medicine based on paracetamol and acetylsalicylic acid.

• Relpax (Eletriptan) – promotes vasoconstriction of the brain, acts selectively, providing a therapeutic effect only where it is needed and does not affect other vessels of the body.

Preventive agents

Preventive medications are useful if migraine attacks occur more than once a week. Such medicines must be taken daily. Preventive agents are divided into 2 groups:

The most effective preventive means:

• Inderal (beta-blocker) – helps to reduce the frequency and strength of contractions of the heart muscle, resulting in lower blood pressure.

• Cardizem (Procardia) – drugs that normalize heart rhythm and lower blood pressure.

• Topral in the form of tablets – works as an antidepressant.

Antidepressants

Headache, migraine exhaust, weaken the body, a person becomes irritable, lethargic, sleeps poorly, his appetite disappears. Antidepressants relieve fatigue, anxiety, improve sleep, mood, increase appetite:

• Amitriptyline (tablets, solution for injection) is a migraine medicine that has a pronounced hypnotic and sedative effect.

• Cyproheptadine (syrup, tablets) also has sedative and hypnotic properties.

• Medicines based on valproic acid (Apilepsin, Depakine, Konvuleks) are effective drugs that can have side effects.

Combination preparations for migraine

Caffeine or codeine and phenobarbital preparations are also effective headache remedies:

• Askofen,

• Kaffetin,

• Migrenol,

• Pentalgin,

• Sedalgin-Neo,

• Solpadein,

• Tetralgin,

• Citramon P.

Combination spasm relievers:

• Bral,

• Spazgan,

• Spazmalgon.

Triptan preparations

Triptans are fast-acting migraine medications that are effective due to the following properties:

• promote constriction of cerebral vessels,

• have the ability to block pain at the level of trigeminal nerve receptors,

• alleviate the accompanying symptoms of migraine (remove nausea, vomiting).

Triptans are available as tablets, suppositories, and nasal sprays. The most popular drugs in this group:

• Amigrenin,

• Zolmitriptan,

• Zomig,

• Imigran,

• Noramig,

• Rapided,

• Relpax,

• Sumamigren,

• Sumatriptan,

• Eletriptan.