Side effects of gabapentin 800 mg: Gabapentin Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing
Gabapentin Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing
gabapentin 800 mg tablet
Color: whiteShape: oblongImprint: 1 3
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 600 mg tablet
Color: whiteShape: oblongImprint: 1 2
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 600 mg tablet
Color: whiteShape: ovalImprint: ZE 72
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 600 mg tablet
Color: whiteShape: oblongImprint: S G 1 77
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 300 mg capsule
Color: yellowShape: oblongImprint: SG 180
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 800 mg tablet
Color: whiteShape: ovalImprint: T 3
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 100 mg capsule
Color: whiteShape: oblongImprint: 103
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 400 mg capsule
Color: orangeShape: oblongImprint: SG 181
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 400 mg capsule
Color: orange,light brownShape: oblongImprint: logo and 667 logo and 667
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 100 mg capsule
Color: whiteShape: oblongImprint: AHD 100
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 400 mg capsule
Color: orangeShape: oblongImprint: 214
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 300 mg capsule
Color: yellowShape: oblongImprint: 104
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 300 mg capsule
Color: yellow,caramelShape: oblongImprint: AHD 300
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 300 mg capsule
Color: yellowShape: oblongImprint: 215
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 100 mg capsule
Color: whiteShape: oblongImprint: SG 179
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 300 mg capsule
Color: buffShape: oblongImprint: IP 102 IP 102
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 600 mg tablet
Color: whiteShape: ovalImprint: 2 02
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 800 mg tablet
Color: whiteShape: ovalImprint: G 13
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 100 mg capsule
Color: whiteShape: oblongImprint: 216
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 600 mg tablet
Color: whiteShape: ovalImprint: T 1
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 800 mg tablet
Color: whiteShape: ellipticalImprint: O E 800
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 300 mg capsule
Color: yellowShape: oblongImprint: 300 mg IG322
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 600 mg tablet
Color: whiteShape: ellipticalImprint: O E 600
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 400 mg capsule
Color: orangeShape: oblongImprint: 400 mg IG323
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 800 mg tablet
Color: whiteShape: oblongImprint: S G 1 78
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 300 mg capsule
Color: yellow,whiteShape: oblongImprint: APO 113
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 600 mg tablet
Color: whiteShape: ovalImprint: NT 150
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 800 mg tablet
Color: whiteShape: ovalImprint: NT 151
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 300 mg capsule
Color: yellow,light brownShape: oblongImprint: logo and 2666 logo and 2666
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 800 mg tablet
Color: whiteShape: ovalImprint: ZE 71
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 600 mg tablet
Color: whiteShape: ovalImprint: G 31
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 600 mg tablet
Color: whiteShape: ellipticalImprint: G 21
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 400 mg capsule
Color: orangeShape: oblongImprint: 105
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 100 mg capsule
Color: whiteShape: oblongImprint: D 02
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 100 mg capsule
Color: white,light brownShape: oblongImprint: logo and 665 logo and 665
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 400 mg capsule
Color: orange,whiteShape: oblongImprint: APO 114
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 800 mg tablet
Color: whiteShape: ellipticalImprint: G 8
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 100 mg capsule
Color: whiteShape: oblongImprint: IP 101 IP 101
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 300 mg capsule
Color: yellowShape: oblongImprint: 138 138
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 400 mg capsule
Color: orangeShape: oblongImprint: D 04
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 300 mg capsule
Color: yellowShape: oblongImprint: D 03
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 600 mg tablet
Color: whiteShape: ellipticalImprint: G 6
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 100 mg capsule
Color: whiteShape: oblongImprint: 137 137
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 400 mg capsule
Color: orange,whiteShape: oblongImprint: OE B58 400 mg
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 300 mg capsule
Color: yellow,whiteShape: oblongImprint: OE B57 300 mg
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 100 mg capsule
Color: whiteShape: oblongImprint: OE B56 100 mg
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 400 mg capsule
Color: light caramelShape: oblongImprint: IP 103 IP 103
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 600 mg tablet
Color: whiteShape: ovalImprint: GAB 600 APO
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 800 mg tablet
Color: whiteShape: ovalImprint: GAB 800 APO
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 600 mg tablet
Color: whiteShape: ellipticalImprint: NT 16
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 600 mg tablet
Color: whiteShape: ellipticalImprint: D 24
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 800 mg tablet
Color: whiteShape: ellipticalImprint: D 25
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 400 mg capsule
Color: orangeShape: oblongImprint: 400 mg 234
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 300 mg capsule
Color: yellowShape: oblongImprint: 300 mg 235
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 800 mg tablet
Color: light grayShape: oblongImprint: logo and 637
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 100 mg capsule
Color: whiteShape: oblongImprint: APO 112
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 400 mg capsule
Color: orangeShape: oblongImprint: Neurontin 400 mg PD
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 300 mg capsule
Color: yellowShape: oblongImprint: Neurontin 300 mg PD
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 100 mg capsule
Color: whiteShape: oblongImprint: Neurontin 100 mg PD
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 400 mg capsule
Color: orangeShape: oblongImprint: 139 139
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 100 mg capsule
Color: whiteShape: oblongImprint: 100 mg IG321
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 400 mg capsule
Color: orangeShape: oblongImprint: G 5028
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 300 mg capsule
Color: yellowShape: oblongImprint: G 5027
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 100 mg capsule
Color: whiteShape: oblongImprint: G 5026
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 800 mg tablet
Color: whiteShape: ellipticalImprint: G 22
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 800 mg tablet
Color: whiteShape: ellipticalImprint: NT 26
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 600 mg tablet
Color: light greenShape: oblongImprint: logo 636
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 800 mg tablet
Color: whiteShape: ovalImprint: logo and 4444 800
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 400 mg capsule
Color: caramelShape: oblongImprint: IP 103 IP 103
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 400 mg capsule
Color: orange,caramelShape: oblongImprint: AHD 400
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 800 mg tablet
Color: whiteShape: oblongImprint: S G 1 78
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 600 mg tablet
Color: whiteShape: oblongImprint: S G 1 77
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
gabapentin 600 mg tablet
Color: whiteShape: ovalImprint: MYLAN G 24
This medicine is a white, oblong, scored, film-coated, tablet imprinted with “1 3”.
Gabapentin Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing
Uses
How to use Gabapentin Tablet, Extended Release 24 Hr
Read the Medication Guide provided by your pharmacist before you start taking gabapentin and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
Take this medication by mouth as directed by your doctor, usually once a day with the evening meal. The dosage is based on your medical condition and response to treatment.
Swallow the tablets whole. Do not crush or chew the tablets. Doing so can release all of the drug at once, increasing the risk of side effects.
During the first 2 weeks of treatment, your doctor may gradually increase your dose so your body can adjust to the medication.
Take this medication regularly to get the most benefit from it.
To help you remember, take it at the same time each day.
Do not take this medication more often or increase your dose without consulting your doctor. Your condition will not improve any faster, and your risk of side effects will increase.
Do not stop taking this medication without consulting your doctor. Some conditions may become worse when this drug is suddenly stopped. Your dose may need to be gradually decreased.
Antacids containing aluminum or magnesium may interfere with the absorption of this medication. If you are also taking an antacid, it is best to take gabapentin at least 2 hours after taking the antacid.
Different forms of gabapentin (such as immediate-release, sustained-release, enacarbil sustained-release) are absorbed in the body differently. Do not switch from one form to the other without consulting your doctor.
Tell your doctor if your condition does not improve or if it worsens.
Side Effects
Drowsiness, loss of coordination, and dizziness may occur.
If any of these effects last or get worse, tell your doctor or pharmacist promptly.
Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including: swelling of the hands/ankles/feet.
A small number of people who take anticonvulsants for any condition (such as seizures, bipolar disorder, pain) may experience depression, suicidal thoughts/attempts, or other mental/mood problems. Tell your doctor right away if you or your family/caregiver notice any unusual/sudden changes in your mood, thoughts, or behavior including signs of depression, suicidal thoughts/attempts, thoughts about harming yourself.
Get medical help right away if you have any very serious side effects, including: slow/shallow breathing.
A very serious allergic reaction to this drug is rare.
However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: fever, swollen lymph nodes, rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.
In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Precautions
Before taking gabapentin, tell your doctor or pharmacist if you are allergic to it; or to gabapentin enacarbil; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, mental/mood problems (such as depression, thoughts of suicide), use/abuse of drugs/alcohol, breathing problems (such as COPD).
This drug may make you dizzy or drowsy. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
Older adults may be more sensitive to the side effects of this drug, especially swelling of the hands/ankles/feet, slow/shallow breathing, dizziness, or loss of coordination. Dizziness and loss of coordination can increase the risk of falling.
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
Gabapentin passes into breast milk. Consult your doctor before breast-feeding.
Interactions
See also How to Use section.
Drug interactions may change how your medications work or increase your risk for serious side effects.
This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.
A product that may interact with this drug is: orlistat.
The risk of serious side effects (such as slow/shallow breathing, severe drowsiness/dizziness) may be increased if this medication is taken with other products that may also cause drowsiness or breathing problems. Tell your doctor or pharmacist if you are using other products such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or antihistamines (such as cetirizine, diphenhydramine).
Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness.
Ask your pharmacist about using those products safely.
Do not use this medication with other medications that contain gabapentin (including gabapentin enacarbil).
This medication may interfere with certain laboratory tests for urine protein. Make sure laboratory personnel and all your doctors know you use this drug.
Does Gabapentin Tablet, Extended Release 24 Hr interact with other drugs you are taking?
Enter your medication into the WebMD interaction checker
Overdose
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: vision changes, severe drowsiness, trouble speaking, weakness.
Do not share this medication with others.
If you miss a dose, take it with food as soon as you remember.
If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.
Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
Images
Next
Save up to 80% on your prescriptions.
Available coupons
Save up to 80% on your prescription with WebMDRx
Drug Survey
Are you currently using Gabapentin Tablet, Extended Release 24 Hr?
This survey is being conducted by the WebMD marketing sciences department.
Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.
ð Ingredients of Gabapentin Canon â Usage of Gabapentin Canon Save Search for analogues Interaction Description of the active ingredients of the preparation Gabapentin Canon The scientific information provided is general and cannot be used to make decisions. Update date: 2022.06.09 Marketing authorization holder: CANONPHARMA PRODUCTION CJSC ATX code: N03AX12 (Gabapentin) Active substance: Rec.INN WHO registered Dosage form
Release form, packaging and composition |
In vitro studies have shown that gabapentin is characterized by the presence of a novel peptide binding site in rat brain tissues, including the hippocampus and cerebral cortex, which may be related to the anticonvulsant activity of gabapentin and its derivatives. Gabapentin in clinically significant concentrations does not bind to other conventional drugs and neurotransmitter receptors in the brain, incl. with GABA A -, GABA B -, benzodiazepine receptors, with NMDA receptors.
7 l. In patients with epilepsy, the concentration of gabapentin in the cerebrospinal fluid is 20% of the corresponding C ss in plasma at the end of the dosing interval.
| G40 | Epilepsy |
| G62.9 | Polyneuropathy, unspecified |
| R52.2 | Other persistent pain (chronic) |
Dosage regimen
The method of administration and dosing regimen of a particular drug depends on its form of release and other factors. The optimal dosage regimen is determined by the doctor. Compliance of the dosage form of a particular drug with indications for use and dosing regimen should be strictly observed.
Individual, depending on indications and treatment regimen.
Side effects
From the side of the nervous system: amnesia, ataxia, confusion, impaired coordination of movements, depression, dizziness, dysarthria, increased nervous excitability, nystagmus, drowsiness, impaired thinking, tremor, convulsions, amblyopia, diplopia, hyperkinesia , strengthening, weakening or absence of reflexes, paresthesia, anxiety, hostility, gait disturbance.
From the digestive system: discoloration of teeth, diarrhea, increased appetite, dry mouth, nausea, vomiting, flatulence, anorexia, gingivitis, abdominal pain, pancreatitis, changes in liver function tests.
From the side of the hematopoietic system: leukopenia, decrease in the number of leukocytes, thrombocytopenic purpura.
From the respiratory system: rhinitis, pharyngitis, cough, pneumonia.
From the musculoskeletal system: myalgia, arthralgia, bone fractures.
From the side of the cardiovascular system: arterial hypertension, manifestations of vasodilation.
From the urinary system: urinary tract infections, urinary incontinence.
Allergic reactions: erythema multiforme, Stevens-Johnson syndrome.
Dermatological reactions: skin maceration, acne, itching, rash.
Other: back pain, fatigue, peripheral edema, impotence, asthenia, malaise, facial swelling, weight gain, accidental injury, asthenia, influenza-like syndrome, blood glucose fluctuations, in children – viral infection, otitis media .
Contraindications for use
Hypersensitivity to gabapentin.
Use in pregnancy and lactation
Adequate and well-controlled studies on the safety of the use of gabapentin during pregnancy and lactation in humans have not been conducted. If necessary, use during pregnancy and lactation should carefully weigh the expected benefit of therapy for the mother and the potential risk to the fetus or infant.
Gabapentin is excreted in breast milk. When used during lactation, the nature of the action of gabapentin on an infant has not been established.
Use for impaired renal function
Patients with impaired renal function, as well as patients on hemodialysis, require adjustment of the dosing regimen.
Pediatric Use
The efficacy and safety of neuropathic pain therapy in patients under 18 years of age have not been established.
Efficacy and safety of gabapentin monotherapy in the treatment of partial seizures in children under 12 years of age and additional therapy with gabapentin in the treatment of partial seizures in children under 3 years of age have not been established
Use in elderly patients
Elderly patients may require dosage adjustment gabapentin due to the fact that in this category of patients, a decrease in renal clearance is possible.
Special instructions
Abrupt discontinuation of anticonvulsant therapy in patients with partial seizures may provoke status convulsions. If necessary, dose reduction, discontinuation of gabapentin or replacement with an alternative agent should be gradual over a period of at least 1 week.
Gabapentin is not an effective treatment for absence seizures.
False-positive urine protein test results have been reported when co-administered with other anticonvulsants. To determine the protein in the urine, it is recommended to use a more specific method of precipitation of sulfosalicylic acid.
Patients with impaired renal function, as well as patients on hemodialysis, require adjustment of the dosing regimen.
Elderly patients may require correction of the dosing regimen of gabapentin due to the fact that in this category of patients a decrease in renal clearance is possible.
The efficacy and safety of neuropathic pain therapy in patients under 18 years of age have not been established.
The efficacy and safety of gabapentin monotherapy in the treatment of partial seizures in children under 12 years of age and additional therapy with gabapentin in the treatment of partial seizures in children under 3 years of age have not been established.
Avoid drinking alcohol during treatment.
Influence on the ability to drive vehicles and mechanisms
Before determining the individual response to treatment, the patient should refrain from potentially hazardous activities associated with the need for concentration and increased speed of psychomotor reactions.
Drug interactions
Simultaneous use with antacids reduces the absorption of gabapentin from the gastrointestinal tract.
When used simultaneously with felbamate, an increase in T 1/2 felbamate is possible.
With simultaneous use, a case of an increase in the concentration of phenytoin in the blood plasma is described.
Keep
If you want to place a link to the description of this drug – use this code
Gabapentin Canon .
Description of the drug in the reference book Vidal.
Rec.INN drug interaction Included in preparations: Pharmacological action Antiepileptic agent. According to the chemical structure, it is similar to GABA, which acts as an inhibitory neurotransmitter in the central nervous system. The mechanism of action of gabapentin is believed to be different from other anticonvulsants that act through GABA synapses (including valproate, barbiturates, benzodiazepines, GABA transaminase inhibitors, GABA uptake inhibitors, GABA agonists, and GABA prodrugs). The mechanism of action of gabapentin has not been definitively established. PharmacokineticsGabapentin is absorbed from the gastrointestinal tract. After oral administration, C max of gabapentin in plasma is reached after 2-3 hours. Absolute bioavailability is about 60%. Reception simultaneously with food (including those with a high fat content) does not affect the pharmacokinetics of gabapentin. Gabapentin does not bind to plasma proteins and has a V d 57. Gabapentin is excreted by the kidneys only. T 1/2 does not depend on the dose and averages 5-7 hours. The clearance of gabapentin is reduced in the elderly and in patients with impaired renal function. The elimination rate constant, plasma and renal clearance of gabapentin are directly proportional to creatinine clearance. Gabapentin is removed from plasma by hemodialysis. Plasma concentrations of gabapentin in children were similar to those in adults. Indications of the active substance |
In vitro studies have shown that gabapentin is characterized by the presence of a novel peptide binding site in rat brain tissues, including the hippocampus and cerebral cortex, which may be related to the anticonvulsant activity of gabapentin and its derivatives. Gabapentin in clinically significant concentrations does not bind to other conventional drugs and neurotransmitter receptors in the brain, incl. with GABA A -, GABA B -, benzodiazepine receptors, with NMDA receptors.
7 l. In patients with epilepsy, the concentration of gabapentin in the cerebrospinal fluid is 20% of the corresponding C ss in plasma at the end of the dosing interval.
| G40 | Epilepsy |
| G62.9 | Polyneuropathy, unspecified |
| R52.2 | Other persistent pain (chronic) |
Dosing regimen
Individual, depending on indications and treatment regimen.
Side effects
From the side of the nervous system: amnesia, ataxia, confusion, impaired coordination of movements, depression, dizziness, dysarthria, increased nervous excitability, nystagmus, drowsiness, impaired thinking, tremor, convulsions, amblyopia, diplopia, hyperkinesia , strengthening, weakening or absence of reflexes, paresthesia, anxiety, hostility, gait disturbance.
From the digestive system: discoloration of teeth, diarrhea, increased appetite, dry mouth, nausea, vomiting, flatulence, anorexia, gingivitis, abdominal pain, pancreatitis, changes in liver function tests.
From the side of the hematopoietic system: leukopenia, decrease in the number of leukocytes, thrombocytopenic purpura.
From the respiratory system: rhinitis, pharyngitis, cough, pneumonia.
From the musculoskeletal system: myalgia, arthralgia, bone fractures.
From the side of the cardiovascular system: arterial hypertension, manifestations of vasodilation.
From the urinary system: urinary tract infections, urinary incontinence.
Allergic reactions: erythema multiforme, Stevens-Johnson syndrome.
Dermatological reactions: skin maceration, acne, itching, rash.
Other: back pain, fatigue, peripheral edema, impotence, asthenia, malaise, facial swelling, weight gain, accidental injury, asthenia, influenza-like syndrome, blood glucose fluctuations, in children – viral infection, otitis media .
Contraindications for use
Hypersensitivity to gabapentin.
Use in pregnancy and lactation
Adequate and well-controlled studies on the safety of the use of gabapentin during pregnancy and lactation in humans have not been conducted. If necessary, use during pregnancy and lactation should carefully weigh the expected benefit of therapy for the mother and the potential risk to the fetus or infant.
Gabapentin is excreted in breast milk. When used during lactation, the nature of the action of gabapentin on an infant has not been established.
Use for impaired renal function
Patients with impaired renal function, as well as patients on hemodialysis, require adjustment of the dosing regimen.
Pediatric Use
The efficacy and safety of neuropathic pain therapy in patients under 18 years of age have not been established.
Efficacy and safety of gabapentin monotherapy in the treatment of partial seizures in children under 12 years of age and additional therapy with gabapentin in the treatment of partial seizures in children under 3 years of age have not been established
Use in elderly patients
Elderly patients may require dosage adjustment gabapentin due to the fact that in this category of patients, a decrease in renal clearance is possible.
Special instructions
Abrupt discontinuation of anticonvulsant therapy in patients with partial seizures may provoke status convulsions. If necessary, dose reduction, discontinuation of gabapentin or replacement with an alternative agent should be gradual over a period of at least 1 week.
Gabapentin is not an effective treatment for absence seizures.
False-positive urine protein test results have been reported when co-administered with other anticonvulsants. To determine the protein in the urine, it is recommended to use a more specific method of precipitation of sulfosalicylic acid.
Patients with impaired renal function, as well as patients on hemodialysis, require adjustment of the dosing regimen.
Elderly patients may require correction of the dosing regimen of gabapentin due to the fact that in this category of patients a decrease in renal clearance is possible.
The efficacy and safety of neuropathic pain therapy in patients under 18 years of age have not been established.