Side effects of lisinopril 10 mg tablets. Lisinopril Side Effects: Understanding Risks and Management
What are the common side effects of lisinopril. How can you manage dizziness caused by lisinopril. When should you seek medical attention for lisinopril side effects. What are the signs of a serious allergic reaction to lisinopril.
Common Side Effects of Lisinopril: What to Expect
Lisinopril, an ACE inhibitor commonly prescribed for high blood pressure and heart conditions, can cause side effects in some individuals. While many people experience no or only minor side effects, it’s important to be aware of potential reactions. Here are the most common side effects experienced by more than 1 in 100 people taking lisinopril:
- Dry, persistent cough
- Dizziness or lightheadedness
- Headaches
- Nausea and vomiting
- Diarrhea
- Itching or mild skin rash
- Blurred vision
Managing a Persistent Cough
One of the most notable side effects of lisinopril is a dry, tickly cough that doesn’t improve with typical cough medicines. How long does this cough typically last? The cough may persist for up to a month, even after discontinuing the medication. If the cough significantly impacts your quality of life or sleep, consult your doctor about alternative treatments.
Dealing with Dizziness
Feeling dizzy or lightheaded, especially when changing positions, is another common side effect of lisinopril. What can you do to manage this symptom? Try these strategies:
- Change positions slowly, especially when getting up from a lying or sitting position
- If you feel dizzy, sit or lie down until the sensation passes
- Avoid driving or operating machinery when experiencing dizziness
- Stay hydrated and avoid excessive alcohol consumption
Gastrointestinal Side Effects: Nausea, Vomiting, and Diarrhea
Lisinopril can sometimes cause gastrointestinal disturbances. How should you manage these symptoms? For both vomiting and diarrhea, the key is to prevent dehydration:
- Drink plenty of fluids, such as water or electrolyte solutions
- Take small, frequent sips to avoid overwhelming your stomach
- Monitor for signs of dehydration, such as decreased urination or dark urine
- Consult a pharmacist before taking any over-the-counter medications for these symptoms
If you experience severe or prolonged gastrointestinal symptoms, it’s crucial to inform your doctor. They may recommend temporarily discontinuing lisinopril until your condition improves.
Skin Reactions and Visual Disturbances
Lisinopril can occasionally cause skin reactions or affect vision. What should you do if you experience these side effects?
Itching and Skin Rash
For mild itching or skin rash, an over-the-counter antihistamine may provide relief. Always consult a pharmacist to ensure the antihistamine is suitable for you, especially if you’re taking other medications.
Blurred Vision
If you experience blurred vision while taking lisinopril, it’s important to exercise caution. Avoid activities that require clear vision, such as driving or operating machinery. If the visual disturbance persists for more than a couple of days, contact your healthcare provider, as they may need to adjust your treatment.
Recognizing Serious Side Effects: When to Seek Medical Attention
While rare, lisinopril can cause serious side effects that require immediate medical attention. What are the warning signs to watch for?
- Yellowing of the skin or eyes (jaundice), indicating potential liver problems
- Unusual paleness, fatigue, or easy bruising/bleeding, which may suggest blood disorders
- Severe stomach pain, possibly indicating pancreatitis
- Swollen ankles, blood in urine, or decreased urination, which could signal kidney issues
If you experience any of these symptoms, contact your doctor or seek medical help immediately.
Emergency Situations: Recognizing Life-Threatening Reactions
In rare cases, lisinopril can cause severe reactions that require immediate emergency care. What symptoms indicate a need for urgent medical attention?
- Sudden weakness on one side of the body, trouble speaking, or vision changes (possible stroke symptoms)
- Rapid heartbeat, chest pain, or tightness (potential heart problems)
- Shortness of breath, wheezing, or chest tightening (possible lung issues)
If you experience any of these symptoms, call emergency services or go to the nearest emergency room immediately.
Anaphylaxis: A Rare but Serious Allergic Reaction
Although extremely rare, lisinopril can cause a severe allergic reaction known as anaphylaxis. What are the signs of anaphylaxis?
- Sudden swelling of the lips, mouth, throat, or tongue
- Difficulty breathing or swallowing
- Severe skin rash or itching
- Feeling faint or lightheaded
Anaphylaxis is a medical emergency requiring immediate attention. If you suspect you’re experiencing an allergic reaction to lisinopril, seek emergency medical care immediately.
Monitoring and Managing Side Effects: Tips for Lisinopril Users
To ensure safe and effective use of lisinopril, it’s important to monitor your body’s response to the medication. How can you effectively manage potential side effects?
- Keep a symptom diary to track any changes in your health after starting lisinopril
- Communicate openly with your healthcare provider about any side effects you experience
- Don’t hesitate to ask questions about your medication and its potential effects
- Never stop taking lisinopril abruptly without consulting your doctor
- Be aware of potential drug interactions and inform all healthcare providers about your lisinopril use
Remember, while side effects can occur, many people take lisinopril without experiencing significant problems. Your healthcare provider can help you weigh the benefits of the medication against any potential risks.
Special Considerations: Lisinopril Use in Specific Populations
Certain groups may need to take extra precautions when using lisinopril. What special considerations should be taken into account for different populations?
Pregnancy and Breastfeeding
Lisinopril is not recommended during pregnancy, especially in the second and third trimesters, as it can cause harm to the developing fetus. If you’re pregnant or planning to become pregnant, inform your doctor immediately. For breastfeeding mothers, consult your healthcare provider to discuss the potential risks and benefits.
Elderly Patients
Older adults may be more sensitive to the effects of lisinopril, particularly dizziness and changes in blood pressure. Closer monitoring may be necessary, and dosage adjustments might be required.
Patients with Kidney Problems
Since lisinopril is primarily eliminated through the kidneys, individuals with kidney disease may need dose adjustments. Regular kidney function tests may be necessary to ensure safe use of the medication.
Alternative Treatments: Options When Lisinopril Isn’t Suitable
If you experience persistent or severe side effects from lisinopril, your doctor may consider alternative treatments. What other options are available for managing high blood pressure or heart conditions?
- Other ACE inhibitors with different side effect profiles
- Angiotensin II receptor blockers (ARBs)
- Calcium channel blockers
- Beta-blockers
- Diuretics
The choice of alternative medication will depend on your specific medical condition, overall health, and individual response to different treatments. Always work closely with your healthcare provider to find the most suitable option for your needs.
Understanding the potential side effects of lisinopril empowers you to make informed decisions about your health. By staying vigilant, communicating with your healthcare provider, and knowing when to seek medical attention, you can maximize the benefits of this medication while minimizing risks. Remember, your health and well-being are paramount, and there are always options available if lisinopril proves unsuitable for you.
Side effects of lisinopril – NHS
Like all medicines, lisinopril can cause side effects in some people, but many people have no side effects or only minor ones.
Common side effects
These common side effects of lisinopril happen in more than 1 in 100 people. Talk to your doctor or pharmacist if these side effects bother you or do not go away:
A dry, tickly cough that does not get better
Cough medicines do not usually help for coughs caused by lisinopril, and sometimes the cough gets better on its own. Talk to your doctor if it bothers you or stops you sleeping, as another medicine may be better. Even if you stop taking lisinopril, the cough may take up to a month to go away.
Feeling dizzy or lightheaded, especially when you stand up or sit up quickly
This is more likely to happen when you start taking lisinopril or move on to a higher dose. If lisinopril makes you feel dizzy when you stand up, try getting up very slowly or stay sitting down until you feel better. If you begin to feel dizzy, lie down so you do not faint, then sit until you feel better.
Do not drive, rike a bike or operate tools or machinery until the dizziness passes. GOV.UK has more information on the law on drugs and driving.
Headaches
Make sure you rest and drink plenty of fluids. Try not to drink too much alcohol. Ask your pharmacist to recommend a painkiller. Talk to your doctor if the headaches last longer than a week or are severe.
Being sick (vomiting)
Take small, frequent sips of fluids, such as water or squash, to prevent dehydration. Speak to a pharmacist if you have signs of dehydration, such as peeing less than usual or having dark, strong-smelling pee.
Do not take any other medicines to treat vomiting without speaking to a pharmacist or doctor first.
If you take contraceptive pills and you’re being sick, your contraception may not protect you from pregnancy. Check the pill packet for advice.
If you get vomiting from a stomach bug or illness, tell your doctor. You may need to stop taking lisinopril for a while until you feel better.
Diarrhoea
Drink plenty of fluids, such as water or squash, to prevent dehydration. Speak to a pharmacist if you have signs of dehydration, such as peeing less than usual or having dark, strong-smelling pee.
Do not take any other medicines to treat diarrhoea without speaking to a pharmacist or doctor first.
If you take contraceptive pills and you have severe diarrhoea, your contraception may not protect you from pregnancy. Check the pill packet for advice.
If you get diarrhoea from a stomach bug or illness, tell your doctor. You may need to stop taking lisinopril for a while until you feel better.
Itching or a mild skin rash
It may help to take an antihistamine, which you can buy from a pharmacy. Check with the pharmacist to see what type is suitable for you.
Blurred vision
Do not drive, ride a bike or use tools or machinery while this is happening. If it lasts for more than a day or two, speak to your doctor as they may need to change your treatment.
Serious side effects
It happens rarely, but some people may have serious side effects when taking lisinopril.
Call a doctor or call 111 straight away if:
- the whites of your eyes turn yellow, or your skin turns yellow although this may be less obvious on brown or black skin – this can be a sign of liver problems
- you’re paler than usual, feel tired, faint or dizzy, have any sign of bleeding (for example bleeding from the gums or bruising more easily than usual), a sore throat, a fever, or you get infections more easily – these can be signs of a blood or bone marrow disorder
- you have severe stomach pain – this can be a sign of an inflamed pancreas (acute pancreatitis)
- you have swollen ankles or blood in your pee or you’re not peeing at all – these can be signs of kidney problems
Immediate action required: Call 999 or go to A&E now if:
- you have weakness on one side of your body, trouble speaking or thinking, loss of balance or blurred eyesight – these can be signs of a stroke
- you have a faster heart rate, chest pain and tightness in your chest – these can be signs of heart problems
- you have shortness of breath, wheezing and tightening of the chest – these can be signs of lung problems
Find your nearest A&E
Serious allergic reaction
In rare cases, it’s possible to have a serious allergic reaction (anaphylaxis) to lisinopril.
Immediate action required: Call 999 now if:
- your lips, mouth, throat or tongue suddenly become swollen
- you’re breathing very fast or struggling to breathe (you may become very wheezy or feel like you’re choking or gasping for air)
- your throat feels tight or you’re struggling to swallow
- your skin, tongue or lips turn blue, grey or pale (if you have black or brown skin, this may be easier to see on the palms of your hands or soles of your feet)
- you suddenly become very confused, drowsy or dizzy
- someone faints and cannot be woken up
- a child is limp, floppy or not responding like they normally do (their head may fall to the side, backwards or forwards, or they may find it difficult to lift their head or focus on your face)
You or the person who’s unwell may also have a rash that’s swollen, raised, itchy, blistered or peeling.
These can be signs of a serious allergic reaction and may need immediate treatment in hospital.
Long term side effects
Taking lisinopril for a long time can sometimes cause your kidneys to not work as well as they should. Your doctor will check how well your kidneys are working with regular blood tests.
Other side effects
These are not all the side effects of lisinopril. For a full list, see the leaflet inside your medicines packet.
Information:
You can report any suspected side effect using the Yellow Card safety scheme.
Visit Yellow Card for further information.
Page last reviewed: 17 December 2021
Next review due: 17 December 2024
Lisinopril Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing
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Lisinopril FT
Precautions
Anaphylactoid and possible related reactions
Presumably because angiotensin-converting enzyme inhibitors interfere with the metabolism of eicosanoids and polypeptides, including endogenous bradykinin, patients receiving ACE inhibitors (including lisinopril) may experience a range of adverse reactions, including serious reactions.
Angioedema of the head and neck: There have been reports of swelling of the face, extremities, lips, tongue, glottis and/or larynx in patients receiving ACE inhibitors. This can happen at any time during treatment. A higher incidence of angioedema has been reported with ACE inhibitors in black patients compared to non-black patients. In such cases, the use of the drug should be immediately discontinued, appropriate therapy and monitoring should be provided until the symptoms are completely and sustainably resolved. Even in cases where the observed swelling of the tongue is not accompanied by difficulty in breathing, patients may require long-term observation, since treatment with antihistamines and corticosteroids may not be enough. There are very rare reports of deaths due to swelling of the larynx or tongue. Patients with tongue, glottis, or larynx involvement are likely to experience airway obstruction, especially in cases of previous airway surgery. To ensure the patency of the respiratory tract, measures of appropriate therapy should be taken immediately, for example, subcutaneous administration of adrenaline 1: 1000 (0. 3 ml to 0.5 ml) (see “Side effect”). Patients with a history of non-ACE inhibitor angioedema may be at an increased risk of developing it when taking ACE inhibitors.
Bowel edema has been reported in patients treated with ACE inhibitors.
Presents with abdominal pain with or without nausea or vomiting; in some cases without a history of angioedema of the face and with a normal level of C-1 esterase. Angioedema was diagnosed by procedures such as abdominal computed tomography or ultrasound, or at the time of surgery, and the symptoms resolved after the ACE inhibitor was discontinued. Intestinal angioedema should be included in the differential diagnosis of abdominal pain in patients receiving ACE inhibitors.
Anaphylactoid reactions during desensitization: Life-threatening anaphylactoid reactions have been observed in patients receiving desensitizing treatment against hymenoptera venom and concomitant use of ACE inhibitors. In patients, these reactions can be avoided with temporary discontinuation of ACE inhibitors, but they may reappear after re-appointment.
Anaphylactoid reactions during hemodialysis: Sudden and potentially life-threatening anaphylactoid reactions have been reported in some patients using high-flux membranes (eg, AN69®) and the simultaneous use of ACE inhibitors. In such patients, dialysis should be stopped immediately and active therapy for anaphylactic reactions should be initiated. In these situations, the use of antihistamines does not lead to the disappearance of symptoms. In these patients, consideration should be given to using a different type of dialysis membrane or switching to a different class of antihypertensive drug. Anaphylactoid reactions have also been reported in patients undergoing LDL apheresis (low-density lipoprotein plasmapheresis) using dextran sulfate.
Hypotension
Excessive hypotension is rarely observed in patients with uncomplicated arterial hypertension receiving lisinopril as monotherapy. In patients with heart failure taking lisinopril, there is usually some decrease in blood pressure with a peak between 6 and 8 hours after a dose. However, discontinuation of therapy due to symptomatic hypotension when the instructions are followed is usually not necessary; care should be taken at the start of treatment. (see “Method of application and dose”).
Risk of excessive hypotension, sometimes associated with oliguria and/or progressive azotemia, rarely with acute renal failure and/or death, occurs in the following conditions: heart failure with systolic blood pressure below 100 mm Hg, hyponatremia, high doses of diuretics, recent heavy diuresis or increase in the dose of a diuretic, dialysis, salt wasting any of these ology. It is advisable to discontinue diuretics (except in patients with heart failure), reduce the diuretic dose, or increase salt intake with caution prior to initiating Lisinopril therapy in patients at risk of excessive hypotension. (see “Side effect”, “Interaction with other drugs”).
Treatment with Lisinopril should not be initiated in acute myocardial infarction in patients at risk of further severe hemodynamic deterioration after treatment with vasodilators (eg, systolic blood pressure of 100 mmHg or less) or cardiogenic shock.
In patients at risk of excessive hypotension, therapy should be started under medical supervision and these patients should be closely monitored during the first two weeks of treatment and whenever the dose of Lisinopril and/or diuretic is increased. This also applies to patients with coronary artery disease or cerebrovascular disease, in whom an excessive decrease in blood pressure can lead to myocardial infarction or stroke.
If hypotension occurs, the patient should be placed in a horizontal position and, if necessary, administer 0.9% sodium chloride intravenously. Transient hypotension is not a contraindication for further use of the drug after normalization of blood pressure by increasing blood volume. If symptomatic hypotension develops, dose reduction or discontinuation of treatment with lisinopril or a concomitant diuretic may be required.
Leukopenia/neutropenia/agranulocytosis
In a study with another ACE inhibitor, captopril, its ability to cause agranulocytosis and bone marrow depression was shown, less often in uncomplicated patients, but more often in patients with renal insufficiency, especially in combination with collagenoses. Marketing experience has shown in rare cases the development of leukopenia / neutropenia and bone marrow depression, while a causal relationship with lisinopril cannot be excluded. Periodic monitoring of white blood cell counts in patients with collagenoses and kidney disease should be considered.
Liver failure
Rarely, ACE inhibitors have been associated with a syndrome that begins with cholestatic jaundice or hepatitis and progresses to fulminant hepatic necrosis and (sometimes) death. The mechanism of this syndrome is unknown. Patients receiving ACE inhibitors who develop jaundice or elevated liver enzymes should stop taking the drug and receive appropriate medical advice.
Aortic stenosis/hypertrophic cardiomyopathy: As with all vasodilators, lisinopril should be used with caution in patients with left ventricular outflow obstruction.
Impaired renal function: Due to RAAS inhibition, changes in renal function can be expected in susceptible patients. In patients with severe CHF, where renal function is dependent on RAAS activity, treatment with ACE inhibitors, including lisinopril, may be associated with oliguria and/or progressive azotemia and rarely with acute renal failure and/or death.
In hypertensive patients with unilateral or bilateral renal artery stenosis, an increase in blood urea nitrogen and serum creatinine is possible. These changes are usually reversible upon discontinuation of the drug and/or diuretic therapy. In such patients, renal function should be monitored during the first few weeks of therapy.
In some patients with arterial hypertension or heart failure without previously diagnosed kidney disease, increases in blood urea nitrogen and serum creatinine are usually minor and transient, especially when taken with diuretics. Changes are most likely in patients with pre-existing renal insufficiency. Dose adjustment and/or discontinuation of the diuretic and/or lisinopril may be required.
In acute acute myocardial infarction, treatment with lisinopril should be initiated with caution in patients with signs of impaired renal function (serum creatinine concentration greater than 2 mg/dL). If renal dysfunction develops during treatment (serum creatinine greater than 3 mg/dL or twice the initial value), the physician should consider discontinuing treatment.
Evaluation of patients with hypertension, heart failure, myocardial infarction should always include an assessment of renal function (see “Method of application and dosage”).
Hyperkalemia: Risk factors for developing hyperkalemia include renal insufficiency, diabetes mellitus, concomitant use of potassium-sparing diuretics, potassium supplements and/or potassium-containing salt substitutes.
Hyperkalemia can lead to serious, sometimes fatal, arrhythmias.
Lisinopril should be used with caution with these agents and frequent monitoring of serum potassium levels is recommended. (see “Interaction with other drugs”).
Cough: By inhibiting the degradation of endogenous bradykinin with all ACE inhibitors, persistent unproductive cough is possible, which stops after discontinuation of therapy.
Surgery / anesthesia: In patients undergoing general surgery or anesthesia with drugs that cause hypotension, lisinopril may block the formation of angiotensin II against the background of compensatory secretion of renin. If arterial hypotension due to this mechanism is noted, it is necessary to replenish the volume of fluid.
Hypoglycemia: In patients with diabetes mellitus taking oral antidiabetic drugs or insulin, it is necessary to maintain constant glycemic control during the first month of therapy with ACE inhibitors. (see “Interaction with other drugs”).
Double blockade of the renin-angiotensin-aldosterone system is associated with an increased risk of hypotension, hyperkalemia and renal dysfunction (including acute renal failure) compared with monotherapy. Dual blockade of the RAAS with Lisinopril, ARB II, or Aliskiren cannot be recommended for any patient, especially for patients with diabetic nephropathy (see “Interaction with other medicinal products”, “Pharmacological properties”).
In some cases, when the combined use of Lisinopril and ARB II is absolutely indicated, careful supervision of a specialist and mandatory monitoring of renal function, water and electrolyte balance, blood pressure is necessary. This refers to the appointment of candesartan or valsartan as adjunctive therapy to lisinopril in patients with CHF. Conducting a double blockade of the RAAS under the close supervision of a specialist and mandatory monitoring of kidney function, water and electrolyte balance and blood pressure is possible in patients with CHF with intolerance to aldosterone antagonists (spironolactone), who have persistent symptoms of CHF, despite other adequate therapy.
It should be remembered that patients with CHF in combination with renal insufficiency (or without it) and connective tissue diseases need strict medical supervision in a hospital at the stage of selecting the dose of Lisinopril and diuretics, since it is in such patients, and especially with severe CHF, that a pronounced decrease in blood pressure is most often possible as a result of the use of diuretics in high doses, hyponatremia or dysfunction kidneys.
In patients with arterial hypertension lisinopril can cause a sharp decrease in blood pressure, especially after the first dose. Most often, arterial hypotension occurs in patients with a deficiency of electrolytes or fluids, receiving diuretics, following a low-salt diet, after vomiting or diarrhea, or after hemodialysis. In such patients, therapy should be initiated under strict medical supervision, preferably in a hospital, at low doses and the dosage adjusted with caution. At the same time, monitoring of kidney function and serum potassium levels is necessary. If possible, diuretic treatment should be discontinued.
Similar rules should be followed when prescribing Lisinopril to patients with coronary artery disease and cerebrovascular insufficiency in whom a sharp drop in blood pressure can lead to myocardial infarction or stroke. In this case, a transient hypotensive reaction is not a contraindication for taking the next dose of the drug.
Before you start taking Lisinopril, if possible, you should normalize the concentration of sodium in the blood and / or replenish the lost volume of fluid, carefully monitor the effect of the initial dose on the patient’s blood pressure level.
In elderly patients from the same dose of Lisinopril, a higher plasma concentration of lisinopril can be created, therefore, special care is required when selecting the dosage of lisinopril in this case, despite the fact that no differences in the antihypertensive effect of lisinopril-containing drugs between elderly and young patients have been identified. For patients over 65 years of age, an initial dose of lisinopril 2.5 mg/day is recommended, as well as monitoring of blood pressure and renal function.
When changes in laboratory parameters against the background of the use of lisinopril (see section “Side Effects”) act individually depending on the severity of these changes and the specific clinical situation. In serious cases, decide on the abolition of lisinopril and the appropriate corrective measures. In all cases, timely monitoring of laboratory parameters is very important.
For example, the concentration of electrolytes and creatinine in the blood serum and the indicators of blood cells should be monitored, especially at the beginning of lisinopril therapy, as well as while using it with immunosuppressants, cytostatics, allopurinol and procainamide.
In some patients with arterial hypertension without obvious renal dysfunction, with simultaneous therapy with lisinopril and diuretics, there may be an increase in the level of urea and blood creatinine. In such a situation, it may be necessary to reduce the dose of the ACE inhibitor or stop the diuretic.
Therapy with lisinopril may lead to an increase in the level of potassium ions in the blood, especially against the background of existing renal or heart failure. Under these conditions, the use of potassium-sparing diuretics or potassium preparations is undesirable. It is also necessary to regularly monitor the level of potassium in the blood.
In view of the fact that the potential risk of agranulocytosis and neutropenia cannot be excluded, periodic monitoring of the blood picture is required. After the abolition of ACE inhibitors, agranulocytosis and neutropenia disappear.
In patients with reduced renal function or after taking sufficiently high doses of lisinopril, rare cases of proteinuria have been noted. In clinically significant proteinuria (>1 g/day), lisinopril should only be used after a careful comparison of the expected benefit and potential risk, as well as with regular monitoring of clinical and laboratory parameters.
Some issues of the tactics of using lisinopril in the presence of changes in laboratory parameters are reflected in other sections of the instructions (“Method of application and dose”, “Interaction with other drugs”).
Pregnancy and lactation
Pregnancy
The use of ACE inhibitors is not recommended during the first trimester of pregnancy and is contraindicated during the second and third trimester of pregnancy (see “Contraindications”).
Use of these drugs during the second and third trimesters of pregnancy reduces kidney function and increases morbidity and risk of fetal and neonatal death. As a result of oligohydramnios, pulmonary hypoplasia and skeletal deformities of the fetus are possible. Potential neonatal side effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is established, Lisinopril should be discontinued as early as possible and switched to alternative antihypertensive agents with an established safety profile for use during pregnancy.
In the absence of an appropriate alternative to ACE inhibitors for a particular patient, she should be informed of the potential risk to the fetus. It is necessary to conduct serial ultrasound examinations. If oligohydramnios is detected, the drug should be discontinued, unless it is vital for the mother. Patients and doctors should be aware that oligohydramnios can occur when the fetus already has irreversible damage.
If ACE inhibitors are used during the second trimester of pregnancy, it is recommended to monitor kidney function and skull development using ultrasound. Newborns whose mothers took lisinopril should be carefully monitored for the presence of arterial hypotension, oliguria and hyperkalemia. In animal experiments, no data on the teratogenic effects of lisinopril have been obtained. There are also no data on the negative effects of the drug on the fetus if used during the first trimester of pregnancy.
Breastfeeding
It is not known whether lisinopril passes into breast milk. Since many drugs are secreted in human milk and because of the risk of severe adverse reactions in infants when using ACE inhibitors, a decision should be made to stop breastfeeding or stop lisinopril, taking into account its importance to the mother.
Pediatric use
Contraindicated in children and adolescents under 18 years of age.
Influence on the ability to drive vehicles and other complex mechanisms
Evidence on this problem in the context of the use of therapeutic dosages of lisinopril-containing agents is currently not available, however, given the possible occurrence of dizziness, their use (including Lisinopril) in such situations should be exercised with caution.
Lisinopril for cats and dogs
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Lisinopril – instructions for use for dogs and cats
Release form and active ingredients | Pharmacological properties | Indications and contraindications | Application principle | Side effects and special instructions
Lisinopril is a drug from the group of angiotensin-converting enzyme (ACE) inhibitors. Each veterinary pharmacy can offer customers this medication, which is widely used in the treatment of dogs and cats. The timely appointment of this medication helps to get rid of negative symptoms and prolong the life of pets with cardiovascular insufficiency.
Formulation and active ingredients
The drug is available in tablet form. Tablets of 5, 10 and 20 mg have a round shape and color ranging from white to pale pink or light gray.
The main active ingredient of the drug is lisinopril dihydrate. As auxiliary components, calcium hydrogen phosphate, corn starch, magnesium stearate and other compounds are introduced into the preparation.
Pharmacological properties
The drug has the following pharmacological action:
- vasodilator;
- hypotensive;
- cardioprotective;
- natriuretic.
Lisinopril promotes the expansion of blood vessels and improves blood circulation. The medicinal product helps to reduce systemic arterial pressure, peripheral vascular resistance, pressure in the pulmonary vessels. The drug avoids myocardial remodeling, prevents hypertrophy, dilatation, spherization of the left ventricle. In addition to these properties, the drug exhibits a nephroprotective effect.
Against the background of long-term medication, systolic function improves markedly and physical endurance of pets with chronic heart failure increases. Proper use of a pharmacological product helps to reduce the likelihood of sudden cardiac death.
Indications and contraindications
Lisinopril is prescribed for pets subject to the following diseases:
- arterial hypertension occurring with frequent rises in blood pressure;
- chronic heart failure, characterized by the inability of the heart to fully perform its functions;
- diabetic nephropathy causing pathological changes in the renal vessels.
The drug is used in the treatment of chronic kidney failure (shown in microdoses). Lisinopril is also used for prophylactic purposes (the drug is able to prevent dysfunction of the left calving of the heart muscle and left ventricular heart failure).
Among the contraindications to treatment with this drug are individual intolerance to the active substance. The drug is used with caution in the treatment of pregnant and lactating animals.
Application principle
Lisinopril is prescribed orally, once a day. A single dosage of the drug is determined by the veterinarian based on the existing diagnosis and the individual characteristics of the patient. Be sure to take into account the condition of the patient’s kidneys and the parallel use of other drugs.
According to the instructions, the drug must be taken as follows:
Initial dose | 0.125 mg/kg |
maintenance dose | 0. 25 mg/kg |
The maximum amount of the drug per day | 0.5 mg/kg |
The duration of the treatment course can take 1-2 months. During the period of therapy with Lisinopril, regular monitoring of the concentration of creatinine in the blood serum is required.
Side effects and special instructions
The drug is well tolerated. Relatively rarely, against the background of its use, side effects may occur, taking the form:
- Tachycardia.
- Hypotension.
- Gastritis.
- Pancreatitis.
- Urticaria.
- Shortness of breath.
- Dyspepsia.
- Thrombocytopenia.
- Leukopenia.
- Anemia.
- Tremor.
- Oppression.
In severe cases, there is a possibility of developing anaphylaxis, which poses a considerable danger to the life of the patient.
It is not recommended to combine Lisinopril with diuretics that enhance its effect, as well as with Indomethacin, which reduces the effectiveness of the product. To exclude the development of acute arterial hypotension, it is important to strictly observe the dosage prescribed by the doctor.
The drug is stored at a temperature not exceeding +25 degrees. The shelf life of the drug is 3 years. Conditions for dispensing from the pharmacy chain – by prescription.
Release form and active ingredients | Pharmacological properties | Indications and contraindications | Application principle | Side effects and special instructions
Lisinopril is a drug from the group of angiotensin-converting enzyme (ACE) inhibitors. Each veterinary pharmacy can offer customers this medication, which is widely used in the treatment of dogs and cats. The timely appointment of this medication helps to get rid of negative symptoms and prolong the life of pets with cardiovascular insufficiency.
Formulation and active ingredients
The drug is available in tablet form. Tablets of 5, 10 and 20 mg have a round shape and color ranging from white to pale pink or light gray.
The main active ingredient of the drug is lisinopril dihydrate. As auxiliary components, calcium hydrogen phosphate, corn starch, magnesium stearate and other compounds are introduced into the preparation.
Pharmacological properties
The drug has the following pharmacological action:
- vasodilator;
- hypotensive;
- cardioprotective;
- natriuretic.
Lisinopril promotes the expansion of blood vessels and improves blood circulation. The medicinal product helps to reduce systemic arterial pressure, peripheral vascular resistance, pressure in the pulmonary vessels. The drug avoids myocardial remodeling, prevents hypertrophy, dilatation, spherization of the left ventricle. In addition to these properties, the drug exhibits a nephroprotective effect.
Against the background of long-term medication, systolic function improves markedly and physical endurance of pets with chronic heart failure increases. Proper use of a pharmacological product helps to reduce the likelihood of sudden cardiac death.
Indications and contraindications
Lisinopril is prescribed for pets subject to the following diseases:
- arterial hypertension occurring with frequent rises in blood pressure;
- chronic heart failure, characterized by the inability of the heart to fully perform its functions;
- diabetic nephropathy causing pathological changes in the renal vessels.
The drug is used in the treatment of chronic kidney failure (shown in microdoses). Lisinopril is also used for prophylactic purposes (the drug is able to prevent dysfunction of the left calving of the heart muscle and left ventricular heart failure).
Among the contraindications to treatment with this drug are individual intolerance to the active substance. The drug is used with caution in the treatment of pregnant and lactating animals.
Application principle
Lisinopril is prescribed orally, once a day. A single dosage of the drug is determined by the veterinarian based on the existing diagnosis and the individual characteristics of the patient. Be sure to take into account the condition of the patient’s kidneys and the parallel use of other drugs.
According to the instructions, the drug must be taken as follows:
Initial dose | 0.125 mg/kg |
maintenance dose | 0.25 mg/kg |
The maximum amount of the drug per day | 0.5 mg/kg |
The duration of the treatment course can take 1-2 months. During the period of therapy with Lisinopril, regular monitoring of the concentration of creatinine in the blood serum is required.
Side effects and special instructions
The drug is well tolerated. Relatively rarely, against the background of its use, side effects may occur, taking the form:
- Tachycardia.