Side effects taking calcium. Calcium: Essential Mineral for Bone Health, Heart Function, and More
What are the health benefits of calcium. How much calcium do you need daily. What are good natural sources of calcium. Who should consider taking calcium supplements. What are potential risks and side effects of calcium supplementation.
Understanding Calcium: A Vital Mineral for Overall Health
Calcium is a crucial mineral that plays a fundamental role in maintaining various bodily functions. While it’s primarily known for its importance in bone health, calcium’s benefits extend far beyond skeletal strength. This essential nutrient contributes to heart rhythm regulation, muscle function, and numerous other physiological processes.
Due to its widespread health benefits, calcium has become one of the most popular dietary supplements in the United States. However, it’s important to understand the proper usage, dosage, and potential risks associated with calcium supplementation.
The Multifaceted Health Benefits of Calcium
Calcium’s importance in human health cannot be overstated. Its primary function is to support bone health by promoting new bone growth and maintaining the strength of existing bone tissue. This makes calcium supplements a standard treatment for osteoporosis and its precursor, osteopenia.
Beyond bone health, calcium offers several other health benefits:
- Heart health: Calcium helps maintain a regular heart rhythm.
- Blood pressure regulation: There’s strong evidence suggesting calcium can help prevent or control high blood pressure.
- PMS symptom relief: Some studies indicate calcium may ease premenstrual syndrome symptoms.
- Cancer prevention: Research suggests that calcium, particularly when combined with vitamin D, may help protect premenopausal women from breast cancer.
- Weight management: While studies are inconclusive, calcium has been investigated as a potential aid in weight loss.
Recommended Calcium Intake: How Much Do You Need?
The Institute of Medicine has established dietary reference intake (DRI) and recommended daily allowance (RDA) standards for calcium. These guidelines provide a framework for ensuring adequate calcium intake across different age groups and life stages.
Daily Calcium Recommendations by Age Group:
- 0-6 months: 200 mg/day
- 7-12 months: 260 mg/day
- 1-3 years: 700 mg/day
- 4-8 years: 1,000 mg/day
- 9-18 years: 1,300 mg/day
- 19-50 years: 1,000 mg/day
- 51-70 years: 1,200 mg/day (women), 1,000 mg/day (men)
- 70+ years: 1,200 mg/day
It’s worth noting that pregnant or breastfeeding women don’t require additional calcium beyond these recommendations. However, individual needs may vary, and it’s always best to consult with a healthcare professional for personalized advice.
Natural Sources of Calcium: Boosting Your Dietary Intake
While supplements can be beneficial, obtaining calcium from natural food sources is often the preferred method. Incorporating calcium-rich foods into your diet can help ensure you meet your daily requirements without relying solely on supplements.
Calcium-Rich Food Sources:
- Dairy products: Milk, cheese, and yogurt
- Leafy green vegetables: Broccoli, kale, and Chinese cabbage
- Fortified foods: Cereals, juices, and soy products
- Tofu
By diversifying your diet to include these calcium-rich foods, you can significantly improve your calcium intake naturally.
Calcium Supplements: Who Should Consider Them?
While a balanced diet can provide sufficient calcium for many individuals, certain groups may benefit from calcium supplementation. Do you fall into one of these categories?
- Vegans or those following plant-based diets
- Individuals with lactose intolerance
- People who consume high amounts of protein or sodium, which can increase calcium excretion
- Those with osteoporosis or weak bones
- Individuals undergoing long-term corticosteroid treatment
- People with bowel or digestive diseases that impair calcium absorption
If you identify with any of these groups, it may be worth discussing calcium supplementation with your healthcare provider.
The Proper Use of Calcium Supplements: Dosage and Timing
When taking calcium supplements, proper dosage and timing are crucial for optimal absorption and effectiveness. How should you incorporate calcium supplements into your routine?
- Take calcium supplements with food for better absorption
- Limit individual doses to 500 milligrams or less
- Split larger doses throughout the day
- Ensure adequate intake of vitamin D and magnesium for proper calcium utilization
It’s important to note that the body’s ability to absorb calcium decreases as the dose increases. Therefore, splitting your calcium intake into smaller doses throughout the day can enhance overall absorption.
Potential Risks and Side Effects of Calcium Supplementation
While calcium supplements are generally safe when taken as directed, they can cause side effects in some individuals. What are the potential risks associated with calcium supplementation?
- Mild gastrointestinal issues: Bloating, gas, and constipation
- Kidney stones: Very high doses of calcium can increase the risk
- Potential cardiovascular risks: Some studies suggest a link between calcium supplements and increased risk of heart attacks and strokes, though this remains a topic of debate among experts
It’s crucial to be aware of potential drug interactions when taking calcium supplements. Calcium can interact with medications for heart disease, diabetes, epilepsy, and other conditions. To avoid interactions, it’s generally recommended to take calcium supplements one to two hours apart from other medications or supplements.
Special Considerations and Precautions for Calcium Intake
While calcium is essential for most people, certain individuals should exercise caution or avoid calcium supplements altogether. Who should be particularly careful with calcium supplementation?
- People with kidney disease
- Individuals with heart problems
- Those diagnosed with sarcoidosis
- People with bone tumors
If you have any of these conditions, it’s crucial to consult with your healthcare provider before starting any calcium supplementation regimen.
It’s also important to be aware of the risks associated with excessive calcium intake. High levels of calcium in the blood can lead to serious symptoms, including nausea, dry mouth, abdominal pain, irregular heartbeat, confusion, and in severe cases, even death.
Understanding Calcium Product Claims
When choosing calcium supplements, it’s essential to be critical of product claims. For instance, “coral calcium” products often make unsubstantiated claims about superior absorption or effectiveness. These claims are unproven, and some coral calcium products may even contain dangerous levels of lead. Stick to reputable, well-established calcium supplements recommended by healthcare professionals.
Calcium plays a vital role in maintaining overall health, from supporting strong bones to regulating heart function. While many people can meet their calcium needs through a balanced diet, supplements can be beneficial for certain groups. However, it’s crucial to use calcium supplements wisely, being mindful of proper dosage, potential side effects, and interactions with other medications. As with any dietary supplement, it’s always best to consult with a healthcare professional before starting a calcium supplementation regimen. By understanding the benefits and risks associated with calcium intake, you can make informed decisions about your health and ensure you’re getting the right amount of this essential mineral.
Supplements, Deficiency, Uses, Effects, and More
Written by R. Morgan Griffin
In this Article
- What Is Calcium?
- Calcium Health Benefits
- Calcium Dosage
- Natural Calcium Sources
- Who Should Consider Calcium Supplements?
- Calcium Risks
Calcium is a mineral that’s well-known for its key role in bone health. Calcium also helps maintain heart rhythm, muscle function, and more. Because of its health benefits, calcium is one of the best-selling supplements in the U.S.
Calcium is key to growing new bone and keeping the bone you have strong. Calcium supplements are standard for treating and preventing osteoporosis — weak and easily broken bones — and its precursor, osteopenia.
Calcium has many other uses. It’s an ingredient in many antacids. Doctors also use it to control high levels of magnesium, phosphorus, and potassium in your blood. There’s good evidence it can help prevent or control high blood pressure.
It may also ease PMS symptoms and play a role in preventing certain cancers. Some research shows that calcium with vitamin D, for instance, may help protect premenopausal women from breast cancer. Calcium also has been studied as a weight loss aid. But so far, these studies have been inconclusive.
The people most likely to have too little calcium are postmenopausal women. Since dairy products are one of the most common sources of calcium, people who are lactose intolerant or vegan may not get enough, either.
The Institute of Medicine has set dietary reference intake (DRI) and recommended daily allowance (RDA) standards for calcium. Getting this amount from the food you eat, with or without supplements, may be enough to keep your bones healthy. Doctors may recommend higher doses.
Category | Calcium: (RDA) |
| 0-6 months | 200 mg/day |
| 7-12 months | 260 mg/day |
| 1-3 years | 700 mg/day |
| 4-8 years | 1,000 mg/day |
| 9-18 years | 1,300 mg/day |
| 19-50 years | 1,000 mg/day |
| 51- 70 years | 1,200 mg/day (women) 1,000 mg/day (men) |
| 70+ years | 1,200 mg/day |
Women who are pregnant or breastfeeding don’t need amounts beyond the recommendations above.
The tolerable upper intake levels (ULs) of a supplement are the highest amount that most people can take safely. For calcium, it’s:
- Infants 0-6 months: 1,000 mg/day
- Infants 7-12 months: 1,500 mg/day
- Children 1-8 years: 2,500 mg/day
- Children/teens 9-18 years: 3,000 mg/day
- Adults 19-50 years: 2,500 mg/day
- Adults over 51 years: 2,000 mg/day
In general, it’s best to take calcium supplements with food. For better absorption, don’t take more than 500 milligrams at one time. Split up larger doses over the course of the day. For your body to make use of calcium properly, you also need to get enough vitamin D and magnesium.
Good sources of calcium include:
- Milk
- Cheese
- Yogurt
- Broccoli, kale, and Chinese cabbage
- Fortified cereals, juices, soy products, and other foods
- Tofu
Experts say that most adults in the U.S. don’t get enough calcium. While improving your diet will help, you may need to take calcium supplements.
You may want to talk to your doctor about calcium supplements and the best way to take them if you:
- Follow a vegan diet
- Can’t digest lactose (you’re lactose intolerant)
- Eat or drink a lot of protein or sodium, which can cause your body to get rid of more calcium
- Have thin, weak bones (osteoporosis)
- Take long-term corticosteroid treatments
- Have bowel or digestive diseases and can’t absorb calcium well
- Side effects. At normal doses, calcium supplements may cause bloating, gas, and constipation. Very high doses of calcium can cause kidney stones. Some studies show taking calcium supplements in addition to a diet high in calcium could raise your risk of heart attacks and strokes, but other experts disagree.
- Interactions. If you take any prescription or over-the-counter medicines regularly, ask your doctor if it’s safe to use calcium supplements. Calcium can interact with drugs for heart disease, diabetes, epilepsy, and other conditions.
High doses of vitamin D can result in dangerously high levels of calcium. High doses of calcium can also prevent your body from absorbing minerals like iron and zinc. In general, take calcium one to two hours apart from other supplements or medications. If you take them at the same time, calcium can bind to those products, and they’ll pass from your body unabsorbed. - Risks. If you have kidney disease, heart problems, sarcoidosis, or bone tumors, don’t take calcium supplements unless your doctor suggests them.
- Overdose. High levels of calcium in your blood can cause nausea, dry mouth, belly pain, an irregular heartbeat, confusion, and even death.
High doses of vitamin D can result in dangerously high levels of calcium. High doses of calcium can also prevent your body from absorbing minerals like iron and zinc. In general, take calcium one to two hours apart from other supplements or medications. If you take them at the same time, calcium can bind to those products, and they’ll pass from your body unabsorbed.There’s no need to use products identified as “coral calcium.” Claims made that coral calcium is better than regular calcium are unproven. Also, coral calcium products may contain dangerous amounts of lead.
Top Picks
Supplements, Deficiency, Uses, Effects, and More
Written by R.
Morgan Griffin
In this Article
- What Is Calcium?
- Calcium Health Benefits
- Calcium Dosage
- Natural Calcium Sources
- Who Should Consider Calcium Supplements?
- Calcium Risks
Calcium is a mineral that’s well-known for its key role in bone health. Calcium also helps maintain heart rhythm, muscle function, and more. Because of its health benefits, calcium is one of the best-selling supplements in the U.S.
Calcium is key to growing new bone and keeping the bone you have strong. Calcium supplements are standard for treating and preventing osteoporosis — weak and easily broken bones — and its precursor, osteopenia.
Calcium has many other uses. It’s an ingredient in many antacids. Doctors also use it to control high levels of magnesium, phosphorus, and potassium in your blood. There’s good evidence it can help prevent or control high blood pressure. It may also ease PMS symptoms and play a role in preventing certain cancers.
Some research shows that calcium with vitamin D, for instance, may help protect premenopausal women from breast cancer. Calcium also has been studied as a weight loss aid. But so far, these studies have been inconclusive.
The people most likely to have too little calcium are postmenopausal women. Since dairy products are one of the most common sources of calcium, people who are lactose intolerant or vegan may not get enough, either.
The Institute of Medicine has set dietary reference intake (DRI) and recommended daily allowance (RDA) standards for calcium. Getting this amount from the food you eat, with or without supplements, may be enough to keep your bones healthy. Doctors may recommend higher doses.
Category | Calcium: (RDA) |
| 0-6 months | 200 mg/day |
| 7-12 months | 260 mg/day |
| 1-3 years | 700 mg/day |
| 4-8 years | 1,000 mg/day |
| 9-18 years | 1,300 mg/day |
| 19-50 years | 1,000 mg/day |
| 51- 70 years | 1,200 mg/day (women) 1,000 mg/day (men) |
| 70+ years | 1,200 mg/day |
Women who are pregnant or breastfeeding don’t need amounts beyond the recommendations above./things-to-know-about-zoloft-sertraline-380791_V2-01-2c8a8e10faea43fc9d7a7d44c5abf3e4.png)
The tolerable upper intake levels (ULs) of a supplement are the highest amount that most people can take safely. For calcium, it’s:
- Infants 0-6 months: 1,000 mg/day
- Infants 7-12 months: 1,500 mg/day
- Children 1-8 years: 2,500 mg/day
- Children/teens 9-18 years: 3,000 mg/day
- Adults 19-50 years: 2,500 mg/day
- Adults over 51 years: 2,000 mg/day
In general, it’s best to take calcium supplements with food. For better absorption, don’t take more than 500 milligrams at one time. Split up larger doses over the course of the day. For your body to make use of calcium properly, you also need to get enough vitamin D and magnesium.
Good sources of calcium include:
- Milk
- Cheese
- Yogurt
- Broccoli, kale, and Chinese cabbage
- Fortified cereals, juices, soy products, and other foods
- Tofu
Experts say that most adults in the U.S. don’t get enough calcium. While improving your diet will help, you may need to take calcium supplements.
You may want to talk to your doctor about calcium supplements and the best way to take them if you:
- Follow a vegan diet
- Can’t digest lactose (you’re lactose intolerant)
- Eat or drink a lot of protein or sodium, which can cause your body to get rid of more calcium
- Have thin, weak bones (osteoporosis)
- Take long-term corticosteroid treatments
- Have bowel or digestive diseases and can’t absorb calcium well
- Side effects. At normal doses, calcium supplements may cause bloating, gas, and constipation. Very high doses of calcium can cause kidney stones. Some studies show taking calcium supplements in addition to a diet high in calcium could raise your risk of heart attacks and strokes, but other experts disagree.
- Interactions. If you take any prescription or over-the-counter medicines regularly, ask your doctor if it’s safe to use calcium supplements. Calcium can interact with drugs for heart disease, diabetes, epilepsy, and other conditions. High doses of vitamin D can result in dangerously high levels of calcium. High doses of calcium can also prevent your body from absorbing minerals like iron and zinc. In general, take calcium one to two hours apart from other supplements or medications. If you take them at the same time, calcium can bind to those products, and they’ll pass from your body unabsorbed.
- Risks. If you have kidney disease, heart problems, sarcoidosis, or bone tumors, don’t take calcium supplements unless your doctor suggests them.
- Overdose. High levels of calcium in your blood can cause nausea, dry mouth, belly pain, an irregular heartbeat, confusion, and even death.
High doses of vitamin D can result in dangerously high levels of calcium. High doses of calcium can also prevent your body from absorbing minerals like iron and zinc. In general, take calcium one to two hours apart from other supplements or medications. If you take them at the same time, calcium can bind to those products, and they’ll pass from your body unabsorbed.There’s no need to use products identified as “coral calcium.” Claims made that coral calcium is better than regular calcium are unproven. Also, coral calcium products may contain dangerous amounts of lead.
Top Picks
Calcium-D3-MIC – instructions for use, doses, side effects, reviews of the drug: capsules, 166.
7 mg + 66.7 IU
0.001 ‰
Analogs
Order in pharmacies
Order
drug
All forms of release, dosages, registration certificates, drug manufacturers, drug characteristics
Calcium-D3-MIK (capsules, 166.7 mg + 66.7 IU), instructions for medical use RU No. LSR-000019/09
Contents
- Active substance
- ATX
- Nosological classification (ICD-10)
- Pharmacological group
- Dosage form
- Compound
- pharmachologic effect
- Description of the dosage form
- Pharmacokinetics
- Indications
- Contraindications
- Use during pregnancy and lactation
- Dosage and administration
- Side effects
- Interaction
- Overdose
- special instructions
- Release form
- Terms of dispensing from pharmacies
- Storage conditions
- Best before date
- Order in Moscow pharmacies
- Reviews
Active ingredient
Calcium carbonate + Colecalciferol (Calcium carbonate + Colecalciferol)
ATX
A12AX Calcium preparations in combination with vitamin D and/or other preparations
Nosological classification (ICD-10)
ICD-10 code list
Pharmacological group
Bone and cartilage metabolism correctors in combinations
Vitamins and vitamin-like products in combinations
Dosage form
Capsules.
Composition
1
capsule contains:
Active ingredients:
Calcium
carbonate – 416.3 mg (in terms of calcium – 166.7 mg),
colecalciferol type 100 CWS – 0.667 mg (in terms of
colecalciferol – 0.001667 mg (66.7 IU)).
Composition
cholecalciferol type 100 CWS: cholecalciferol crystalline, α‑tocopherol,
soybean oil, corn starch, hydrolyzed gelatin, sucrose.
Excipient:
Starch
potato.
Composition of the gelatin capsule shell:
Composition
hard gelatin capsule bodies: gelatin, purified water, titanium dioxide
E171; composition of the cap of a hard gelatin capsule: gelatin, purified water,
titanium dioxide E171, alluring red dye E129, dye
quinoline yellow E104.
Combined
drug, the action of which is due to its constituent components.
Regulates the exchange of calcium and phosphate ions, reduces resorption and increases
bone density, compensates for the lack of calcium ions and vitamin D 3
in the body, enhances the absorption of calcium ions in the intestine and reabsorption
phosphate in the kidneys, promotes bone mineralization.
Calcium
carbonate is involved in the formation of bone tissue, blood clotting,
in maintaining stable cardiac activity, in the implementation of processes
transmission of nerve impulses. The use of calcium and vitamin D 3
prevents an increase in the production of parathyroid hormone, which is
stimulator of increased bone resorption.
Description of dosage form
Capsules
hard, gelatinous No. 0 cylindrical shape with hemispherical ends
with white body and orange lid.
Content
capsules – powder of white or almost white color.
Pharmacokinetics
Vitamin D 3
absorbed in the small intestine. Calcium is absorbed in ionized form
in the proximal small intestine through active
transport mechanism.
Readings
–
Prevention and
treatment and deficiency of calcium and/or vitamin D 3 .
–
With insufficient
intake of calcium and vitamin D 3 into the body against the background
malnutrition.
–
With increased
body needs for calcium and vitamin D 3
during pregnancy and breastfeeding, as well as in children over 12
years during a period of intensive growth.
–
Prevention and
as part of the complex therapy of osteoporosis (menopausal, senile,
“steroid”, idiopathic, etc.).
Contraindications
–
Hypercalcemia
(increased concentration of calcium in the blood).
–
Hypercalciuria
(increased calcium in the urine).
–
Nephurolithiasis.
–
Hypervitaminosis
vitamin D 3 .
–
Increased
sensitivity to the components of the drug.
–
severe renal
failure.
–
active form
tuberculosis.
–
Sarcoidosis.
–
Osteoporosis,
caused by immobilization.
–
Urolithiasis
disease.
–
Atherosclerosis.
–
Childhood
up to 12 years old.
With caution
Renal
insufficiency, benign granulomatosis, taking glycosides and thiazide
diuretics, pregnancy, lactation.
Use in pregnancy and lactation
Daily
the dose should not exceed 1500 mg calcium and 600 IU vitamin D 3 .
Hypercalcemia developing against the background of an overdose during pregnancy
can cause defects in the mental and physical development of the child.
Vitamin D 3
and its metabolites can pass into breast milk, therefore, it is necessary to take into account
intake of calcium and vitamin D 3 from other sources in the mother
and child. An overdose during pregnancy may lead to
mental and physical development of the child.
Dosage and administration
Information for healthcare professionals only.
Are you a healthcare professional?
Adults and children over 12:
2-3 capsules 2 times a day, morning and evening, mainly
while eating.
Side effects
Allergic
reactions, dysfunction of the gastrointestinal tract (constipation or diarrhea, flatulence,
nausea, abdominal pain), hypercalcemia and hypercalciuria (increased
calcium in blood or urine).
Interactions
Information for healthcare professionals only.
Are you a healthcare professional?
Activity
vitamin D 3 may decrease when it is used simultaneously with phenytoin
or barbiturates.
At
simultaneous treatment with cardiac glycosides requires ECG monitoring and
clinical condition, since calcium preparations can potentiate
therapeutic and toxic effects of cardiac glycosides.
Preparations
calcium and vitamin D 3 may increase absorption
tetracyclines from the gastrointestinal tract. Therefore, the time interval
between taking a tetracycline drug and Calcium-D3-MIC should
be at least 3 hours.
For
to prevent a decrease in the absorption of bisphosphonates or sodium fluoride drugs,
it is recommended to take Calcium-D3-MIC not earlier than 2 hours later
after taking them.
Glucocorticosteroids
reduce calcium absorption, so treatment with glucocorticosteroids may
require an increase in the dose of Calcium-D3-MIC.
Simultaneous
treatment with Kolestyramine preparations or laxatives based on
mineral or vegetable oils can reduce the absorption of vitamin D 3 .
At
the simultaneous use of thiazide diuretics increases the risk
the occurrence of hypercalcemia, because they increase tubular
calcium reabsorption. Furosemide and other loop diuretics, on the other hand,
increase the excretion of calcium by the kidneys.
U
patients who are simultaneously taking cardiac glycosides and / or diuretics,
it is necessary to control the concentration of calcium and creatinine in the blood serum.
Overdose
Overdose symptoms:
Anorexia,
thirst, polyuria, decreased appetite, dizziness, fainting,
weakness, nausea, vomiting, hypercalciuria, hypercalcemia, hypercreatinemia.
With prolonged use, calcification of blood vessels and tissues.
Treatment:
Introduction
in the body of a large amount of fluid, the use of loop diuretics
(e.
g. Furosemide), glucocorticosteroids, calcitonin, bisphosphonates. When
Seek medical attention if signs of overdose are detected.
Special instructions
B
during the treatment period, it is necessary to constantly monitor the excretion of calcium ions in the urine
and the concentration of calcium and creatinine ions in plasma (in case of development
calciuria exceeding 7.5 mmol/day (300 mg/day)
reduce dose or stop taking).
Vo
to avoid overdose, additional intake must be taken into account
vitamin D 3 from other sources.
Reception
foods containing oxalates (sorrel, spinach) and phytin (cereals) reduces
calcium absorption, so you should not take Calcium-D3-MIC for
two hours after taking sorrel, spinach, cereals.
Product form
Capsules.
By
10 capsules in a blister pack, 6 blister packs
together with instructions for use are placed in a pack of cardboard.
Terms of dispensing from pharmacies
Without
doctor’s prescription.
Storage conditions
Store
in a place protected from moisture and light at a temperature of 15 ° C
up to 25 °С.
Store
in a place inaccessible to children.
Shelf life
2
of the year.
Not
use after the expiration date.
Update date: 10/31/2022
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The information provided on drug prices is not an offer to sell or buy goods.
The information is intended solely for comparing prices in stationary pharmacies operating in
in accordance with Article 55 of the Federal Law “On the Circulation of Medicines” dated April 12, 2010 No. 61-FZ.
Reviews
Read all reviews and leave your own.
Information for healthcare professionals only.
Are you a healthcare professional?
Calcium-D3-MIC – instructions for use, doses, side effects, reviews of the drug: capsules, 166.7 mg + 66.7 IU
0.001 ‰
Analogs
Order in pharmacies
Order
drug
All forms of release, dosages, registration certificates, drug manufacturers, drug characteristics
Calcium-D3-MIK (capsules, 166.7 mg + 66.7 IU), instructions for medical use RU No. LSR-000019/09
Contents
- Active substance
- ATX
- Nosological classification (ICD-10)
- Pharmacological group
- Dosage form
- Compound
- pharmachologic effect
- Description of the dosage form
- Pharmacokinetics
- Indications
- Contraindications
- Use during pregnancy and lactation
- Dosage and administration
- Side effects
- Interaction
- Overdose
- special instructions
- Release form
- Terms of dispensing from pharmacies
- Storage conditions
- Best before date
- Order in Moscow pharmacies
- Reviews
Active ingredient
Calcium carbonate + Colecalciferol (Calcium carbonate + Colecalciferol)
ATX
A12AX Calcium preparations in combination with vitamin D and/or other preparations
Nosological classification (ICD-10)
ICD-10 code list
Pharmacological group
Bone and cartilage metabolism correctors in combinations
Vitamins and vitamin-like products in combinations
Dosage form
Capsules.
Composition
1
capsule contains:
Active ingredients:
Calcium
carbonate – 416.3 mg (in terms of calcium – 166.7 mg),
colecalciferol type 100 CWS – 0.667 mg (in terms of
colecalciferol – 0.001667 mg (66.7 IU)).
Composition
cholecalciferol type 100 CWS: cholecalciferol crystalline, α‑tocopherol,
soybean oil, corn starch, hydrolyzed gelatin, sucrose.
Excipient:
Starch
potato.
Composition of the gelatin capsule shell:
Composition
hard gelatin capsule bodies: gelatin, purified water, titanium dioxide
E171; composition of the cap of a hard gelatin capsule: gelatin, purified water,
titanium dioxide E171, alluring red dye E129, dye
quinoline yellow E104.
Combined
drug, the action of which is due to its constituent components.
Regulates the exchange of calcium and phosphate ions, reduces resorption and increases
bone density, compensates for the lack of calcium ions and vitamin D 3
in the body, enhances the absorption of calcium ions in the intestine and reabsorption
phosphate in the kidneys, promotes bone mineralization.
Calcium
carbonate is involved in the formation of bone tissue, blood clotting,
in maintaining stable cardiac activity, in the implementation of processes
transmission of nerve impulses. The use of calcium and vitamin D 3
prevents an increase in the production of parathyroid hormone, which is
stimulator of increased bone resorption.
Description of dosage form
Capsules
hard, gelatinous No. 0 cylindrical shape with hemispherical ends
with white body and orange lid.
Content
capsules – powder of white or almost white color.
Pharmacokinetics
Vitamin D 3
absorbed in the small intestine. Calcium is absorbed in ionized form
in the proximal small intestine through active
transport mechanism.
Readings
–
Prevention and
treatment and deficiency of calcium and/or vitamin D 3 .
–
With insufficient
intake of calcium and vitamin D 3 into the body against the background
malnutrition.
–
With increased
body needs for calcium and vitamin D 3
during pregnancy and breastfeeding, as well as in children over 12
years during a period of intensive growth.
–
Prevention and
as part of the complex therapy of osteoporosis (menopausal, senile,
“steroid”, idiopathic, etc.).
Contraindications
–
Hypercalcemia
(increased concentration of calcium in the blood).
–
Hypercalciuria
(increased calcium in the urine).
–
Nephurolithiasis.
–
Hypervitaminosis
vitamin D 3 .
–
Increased
sensitivity to the components of the drug.
–
severe renal
failure.
–
active form
tuberculosis.
–
Sarcoidosis.
–
Osteoporosis,
caused by immobilization.
–
Urolithiasis
disease.
–
Atherosclerosis.
–
Childhood
up to 12 years old.
With caution
Renal
insufficiency, benign granulomatosis, taking glycosides and thiazide
diuretics, pregnancy, lactation.
Use in pregnancy and lactation
Daily
the dose should not exceed 1500 mg calcium and 600 IU vitamin D 3 .
Hypercalcemia developing against the background of an overdose during pregnancy
can cause defects in the mental and physical development of the child.
Vitamin D 3
and its metabolites can pass into breast milk, therefore, it is necessary to take into account
intake of calcium and vitamin D 3 from other sources in the mother
and child. An overdose during pregnancy may lead to
mental and physical development of the child.
Dosage and administration
Information for healthcare professionals only.
Are you a healthcare professional?
Adults and children over 12:
2-3 capsules 2 times a day, morning and evening, mainly
while eating.
Side effects
Allergic
reactions, dysfunction of the gastrointestinal tract (constipation or diarrhea, flatulence,
nausea, abdominal pain), hypercalcemia and hypercalciuria (increased
calcium in blood or urine).
Interactions
Information for healthcare professionals only.
Are you a healthcare professional?
Activity
vitamin D 3 may decrease when it is used simultaneously with phenytoin
or barbiturates.
At
simultaneous treatment with cardiac glycosides requires ECG monitoring and
clinical condition, since calcium preparations can potentiate
therapeutic and toxic effects of cardiac glycosides.
Preparations
calcium and vitamin D 3 may increase absorption
tetracyclines from the gastrointestinal tract. Therefore, the time interval
between taking a tetracycline drug and Calcium-D3-MIC should
be at least 3 hours.
For
to prevent a decrease in the absorption of bisphosphonates or sodium fluoride drugs,
it is recommended to take Calcium-D3-MIC not earlier than 2 hours later
after taking them.
Glucocorticosteroids
reduce calcium absorption, so treatment with glucocorticosteroids may
require an increase in the dose of Calcium-D3-MIC.
Simultaneous
treatment with Kolestyramine preparations or laxatives based on
mineral or vegetable oils can reduce the absorption of vitamin D 3 .
At
the simultaneous use of thiazide diuretics increases the risk
the occurrence of hypercalcemia, because they increase tubular
calcium reabsorption. Furosemide and other loop diuretics, on the other hand,
increase the excretion of calcium by the kidneys.
U
patients who are simultaneously taking cardiac glycosides and / or diuretics,
it is necessary to control the concentration of calcium and creatinine in the blood serum.
Overdose
Overdose symptoms:
Anorexia,
thirst, polyuria, decreased appetite, dizziness, fainting,
weakness, nausea, vomiting, hypercalciuria, hypercalcemia, hypercreatinemia.
With prolonged use, calcification of blood vessels and tissues.
Treatment:
Introduction
in the body of a large amount of fluid, the use of loop diuretics
(e.
g. Furosemide), glucocorticosteroids, calcitonin, bisphosphonates. When
Seek medical attention if signs of overdose are detected.
Special instructions
B
during the treatment period, it is necessary to constantly monitor the excretion of calcium ions in the urine
and the concentration of calcium and creatinine ions in plasma (in case of development
calciuria exceeding 7.5 mmol/day (300 mg/day)
reduce dose or stop taking).
Vo
to avoid overdose, additional intake must be taken into account
vitamin D 3 from other sources.
Reception
foods containing oxalates (sorrel, spinach) and phytin (cereals) reduces
calcium absorption, so you should not take Calcium-D3-MIC for
two hours after taking sorrel, spinach, cereals.
Product form
Capsules.
By
10 capsules in a blister pack, 6 blister packs
together with instructions for use are placed in a pack of cardboard.
Terms of dispensing from pharmacies
Without
doctor’s prescription.
Storage conditions
Store
in a place protected from moisture and light at a temperature of 15 ° C
up to 25 °С.
Store
in a place inaccessible to children.
Shelf life
2
of the year.
Not
use after the expiration date.
Update date: 10/31/2022
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