Side effects taking calcium. Calcium Supplements: Benefits, Risks, and Side Effects Explained
What are the health benefits of calcium supplements. How much calcium do you need daily. Who should consider taking calcium supplements. What are the potential risks and side effects of calcium supplementation. How does calcium interact with other medications and supplements.
Understanding Calcium: Essential Mineral for Bone Health and Beyond
Calcium is a vital mineral that plays a crucial role in maintaining strong bones and teeth. However, its importance extends far beyond skeletal health. This essential nutrient contributes to various bodily functions, including muscle contractions, nerve signaling, and maintaining a regular heartbeat.
While calcium is widely recognized for its bone-building properties, many people are unaware of its other health benefits. Did you know that calcium also helps regulate blood pressure and may even play a role in preventing certain types of cancer?
Key Functions of Calcium in the Body
- Bone and tooth formation and maintenance
- Muscle contraction and relaxation
- Nerve signal transmission
- Blood clotting
- Regulating heartbeat
- Enzyme activation
The Health Benefits of Calcium: More Than Just Strong Bones
While the primary focus of calcium supplementation is often on bone health, this mineral offers a range of other potential benefits. Research has shown that adequate calcium intake may contribute to various aspects of overall health and well-being.
Calcium’s Role in Osteoporosis Prevention
Osteoporosis, characterized by weak and fragile bones, is a significant concern, especially for postmenopausal women. Can calcium supplements help prevent this condition? Studies have shown that calcium, when combined with vitamin D, can indeed help maintain bone density and reduce the risk of fractures in individuals with osteoporosis or its precursor, osteopenia.
Cardiovascular Health and Blood Pressure Regulation
Emerging evidence suggests that calcium may play a role in maintaining cardiovascular health. How does calcium affect blood pressure? Some studies indicate that adequate calcium intake may help lower blood pressure, particularly in individuals with hypertension. However, it’s important to note that the relationship between calcium supplementation and heart health is complex and requires further research.
Potential Cancer Prevention Properties
While more research is needed, some studies have suggested that calcium, particularly when combined with vitamin D, may have protective effects against certain types of cancer. For instance, there is evidence that calcium supplementation may reduce the risk of colorectal cancer. Additionally, some research indicates that calcium with vitamin D might help protect premenopausal women from breast cancer.
Calcium Dosage: How Much Do You Really Need?
Understanding the appropriate calcium dosage is crucial for maintaining optimal health without risking potential side effects. The recommended daily allowance (RDA) for calcium varies depending on age, gender, and life stage.
Recommended Daily Allowance (RDA) for Calcium
- 0-6 months: 200 mg/day
- 7-12 months: 260 mg/day
- 1-3 years: 700 mg/day
- 4-8 years: 1,000 mg/day
- 9-18 years: 1,300 mg/day
- 19-50 years: 1,000 mg/day
- 51-70 years: 1,200 mg/day (women), 1,000 mg/day (men)
- 70+ years: 1,200 mg/day
Is it possible to consume too much calcium? Yes, there are upper intake levels (ULs) established to prevent potential adverse effects. For most adults, the UL is set at 2,500 mg/day for those aged 19-50 and 2,000 mg/day for those over 51.
Natural Sources of Calcium: Beyond Dairy Products
While dairy products are often the first thing that comes to mind when thinking about calcium-rich foods, there are numerous other dietary sources of this essential mineral. For those who are lactose intolerant or follow a vegan diet, it’s crucial to explore alternative calcium sources.
Calcium-Rich Foods to Include in Your Diet
- Leafy green vegetables (e.g., kale, broccoli, Chinese cabbage)
- Fortified plant-based milk alternatives (e.g., soy milk, almond milk)
- Tofu (when prepared with calcium sulfate)
- Fortified cereals and juices
- Nuts and seeds (e.g., almonds, sesame seeds)
- Canned fish with soft bones (e.g., sardines, salmon)
How can you ensure you’re getting enough calcium from your diet? By incorporating a variety of these calcium-rich foods into your meals and snacks, you can significantly boost your calcium intake without relying solely on dairy products.
Who Should Consider Calcium Supplements?
While it’s generally preferable to obtain nutrients from food sources, some individuals may benefit from calcium supplementation. Certain groups are at higher risk of calcium deficiency and may need to consider taking supplements.
Groups at Risk of Calcium Deficiency
- Postmenopausal women
- Individuals with lactose intolerance
- Vegans and vegetarians who don’t consume dairy
- People with malabsorption disorders (e.g., Crohn’s disease, celiac disease)
- Those taking certain medications (e.g., long-term corticosteroids)
- Individuals with osteoporosis or osteopenia
Should everyone take calcium supplements? Not necessarily. It’s important to consult with a healthcare professional before starting any supplementation regimen, as individual needs can vary greatly based on diet, lifestyle, and overall health status.
The Risks and Side Effects of Calcium Supplementation
While calcium supplements can be beneficial for many individuals, they are not without potential risks and side effects. Understanding these potential issues is crucial for making informed decisions about supplementation.
Common Side Effects of Calcium Supplements
- Gastrointestinal discomfort (bloating, gas, constipation)
- Kidney stones (with very high doses)
- Potential increased risk of heart attacks and strokes (controversial)
How can you minimize the risk of side effects when taking calcium supplements? Start with lower doses and gradually increase as tolerated. Taking calcium supplements with food can also help reduce gastrointestinal side effects.
Interactions with Medications and Other Supplements
Calcium can interact with various medications and other supplements, potentially affecting their absorption or effectiveness. Are you taking any medications that might interact with calcium? Some common interactions include:
- Antibiotics (e.g., tetracyclines, fluoroquinolones)
- Bisphosphonates (used to treat osteoporosis)
- Thyroid medications
- Iron supplements
- Zinc supplements
To avoid potential interactions, it’s generally recommended to take calcium supplements at least two hours apart from other medications or supplements.
Optimizing Calcium Absorption: Tips for Maximizing Benefits
Simply taking a calcium supplement doesn’t guarantee that your body will absorb and utilize it effectively. Several factors can influence calcium absorption and its overall effectiveness in the body.
Factors Affecting Calcium Absorption
- Vitamin D levels
- Magnesium intake
- Phytic acid and oxalic acid in foods
- Age (absorption decreases with age)
- Hormonal changes (e.g., during menopause)
How can you enhance calcium absorption? Ensuring adequate vitamin D intake is crucial, as this nutrient plays a vital role in calcium absorption. Additionally, consuming calcium-rich foods or supplements in smaller, more frequent doses throughout the day can improve absorption compared to taking a large dose all at once.
Combining Calcium with Other Nutrients
For optimal bone health and overall well-being, calcium often works best when combined with other key nutrients. Which nutrients complement calcium? Consider the following combinations:
- Calcium + Vitamin D: Enhances calcium absorption and utilization
- Calcium + Magnesium: Supports bone health and muscle function
- Calcium + Vitamin K: Aids in proper calcium distribution in the body
When choosing a calcium supplement, look for products that include these complementary nutrients for maximum benefit.
Debunking Calcium Myths: Separating Fact from Fiction
There are numerous misconceptions surrounding calcium supplementation and its effects on health. Let’s address some common myths and provide evidence-based information to clarify these issues.
Myth: More Calcium is Always Better
Is it true that consuming more calcium will always lead to stronger bones? Not necessarily. While adequate calcium intake is crucial for bone health, excessive consumption doesn’t provide additional benefits and may even be harmful. Stick to the recommended daily allowances unless otherwise advised by a healthcare professional.
Myth: Coral Calcium is Superior to Other Forms
Have you heard claims about the superiority of coral calcium? Despite marketing claims, there is no scientific evidence to suggest that coral calcium is more effective than other forms of calcium supplements. In fact, some coral calcium products may contain harmful contaminants like lead.
Myth: Calcium Supplements Alone Can Prevent Osteoporosis
While calcium is essential for bone health, can it single-handedly prevent osteoporosis? The truth is that osteoporosis prevention requires a multifaceted approach. This includes adequate calcium and vitamin D intake, regular weight-bearing exercise, and other lifestyle factors. Calcium supplements can be part of a comprehensive strategy but are not a magic solution on their own.
By understanding these myths and the true nature of calcium’s role in health, individuals can make more informed decisions about their calcium intake and supplementation needs.
Supplements, Deficiency, Uses, Effects, and More
Written by R. Morgan Griffin
In this Article
- What Is Calcium?
- Calcium Health Benefits
- Calcium Dosage
- Natural Calcium Sources
- Who Should Consider Calcium Supplements?
- Calcium Risks
Calcium is a mineral that’s well-known for its key role in bone health. Calcium also helps maintain heart rhythm, muscle function, and more. Because of its health benefits, calcium is one of the best-selling supplements in the U.S.
Calcium is key to growing new bone and keeping the bone you have strong. Calcium supplements are standard for treating and preventing osteoporosis — weak and easily broken bones — and its precursor, osteopenia.
Calcium has many other uses. It’s an ingredient in many antacids. Doctors also use it to control high levels of magnesium, phosphorus, and potassium in your blood. There’s good evidence it can help prevent or control high blood pressure. It may also ease PMS symptoms and play a role in preventing certain cancers. Some research shows that calcium with vitamin D, for instance, may help protect premenopausal women from breast cancer. Calcium also has been studied as a weight loss aid. But so far, these studies have been inconclusive.
The people most likely to have too little calcium are postmenopausal women. Since dairy products are one of the most common sources of calcium, people who are lactose intolerant or vegan may not get enough, either.
The Institute of Medicine has set dietary reference intake (DRI) and recommended daily allowance (RDA) standards for calcium. Getting this amount from the food you eat, with or without supplements, may be enough to keep your bones healthy. Doctors may recommend higher doses.
Category | Calcium: (RDA) |
0-6 months | 200 mg/day |
7-12 months | 260 mg/day |
1-3 years | 700 mg/day |
4-8 years | 1,000 mg/day |
9-18 years | 1,300 mg/day |
19-50 years | 1,000 mg/day |
51- 70 years | 1,200 mg/day (women) 1,000 mg/day (men) |
70+ years | 1,200 mg/day |
Women who are pregnant or breastfeeding don’t need amounts beyond the recommendations above.
The tolerable upper intake levels (ULs) of a supplement are the highest amount that most people can take safely. For calcium, it’s:
- Infants 0-6 months: 1,000 mg/day
- Infants 7-12 months: 1,500 mg/day
- Children 1-8 years: 2,500 mg/day
- Children/teens 9-18 years: 3,000 mg/day
- Adults 19-50 years: 2,500 mg/day
- Adults over 51 years: 2,000 mg/day
In general, it’s best to take calcium supplements with food. For better absorption, don’t take more than 500 milligrams at one time. Split up larger doses over the course of the day. For your body to make use of calcium properly, you also need to get enough vitamin D and magnesium.
Good sources of calcium include:
- Milk
- Cheese
- Yogurt
- Broccoli, kale, and Chinese cabbage
- Fortified cereals, juices, soy products, and other foods
- Tofu
Experts say that most adults in the U.S. don’t get enough calcium. While improving your diet will help, you may need to take calcium supplements.
You may want to talk to your doctor about calcium supplements and the best way to take them if you:
- Follow a vegan diet
- Can’t digest lactose (you’re lactose intolerant)
- Eat or drink a lot of protein or sodium, which can cause your body to get rid of more calcium
- Have thin, weak bones (osteoporosis)
- Take long-term corticosteroid treatments
- Have bowel or digestive diseases and can’t absorb calcium well
- Side effects. At normal doses, calcium supplements may cause bloating, gas, and constipation. Very high doses of calcium can cause kidney stones. Some studies show taking calcium supplements in addition to a diet high in calcium could raise your risk of heart attacks and strokes, but other experts disagree.
- Interactions. If you take any prescription or over-the-counter medicines regularly, ask your doctor if it’s safe to use calcium supplements. Calcium can interact with drugs for heart disease, diabetes, epilepsy, and other conditions. High doses of vitamin D can result in dangerously high levels of calcium. High doses of calcium can also prevent your body from absorbing minerals like iron and zinc. In general, take calcium one to two hours apart from other supplements or medications. If you take them at the same time, calcium can bind to those products, and they’ll pass from your body unabsorbed.
- Risks. If you have kidney disease, heart problems, sarcoidosis, or bone tumors, don’t take calcium supplements unless your doctor suggests them.
- Overdose. High levels of calcium in your blood can cause nausea, dry mouth, belly pain, an irregular heartbeat, confusion, and even death.
There’s no need to use products identified as “coral calcium.” Claims made that coral calcium is better than regular calcium are unproven. Also, coral calcium products may contain dangerous amounts of lead.
Top Picks
Supplements, Deficiency, Uses, Effects, and More
Written by R. Morgan Griffin
In this Article
- What Is Calcium?
- Calcium Health Benefits
- Calcium Dosage
- Natural Calcium Sources
- Who Should Consider Calcium Supplements?
- Calcium Risks
Calcium is a mineral that’s well-known for its key role in bone health. Calcium also helps maintain heart rhythm, muscle function, and more. Because of its health benefits, calcium is one of the best-selling supplements in the U.S.
Calcium is key to growing new bone and keeping the bone you have strong. Calcium supplements are standard for treating and preventing osteoporosis — weak and easily broken bones — and its precursor, osteopenia.
Calcium has many other uses. It’s an ingredient in many antacids. Doctors also use it to control high levels of magnesium, phosphorus, and potassium in your blood. There’s good evidence it can help prevent or control high blood pressure. It may also ease PMS symptoms and play a role in preventing certain cancers. Some research shows that calcium with vitamin D, for instance, may help protect premenopausal women from breast cancer. Calcium also has been studied as a weight loss aid. But so far, these studies have been inconclusive.
The people most likely to have too little calcium are postmenopausal women. Since dairy products are one of the most common sources of calcium, people who are lactose intolerant or vegan may not get enough, either.
The Institute of Medicine has set dietary reference intake (DRI) and recommended daily allowance (RDA) standards for calcium. Getting this amount from the food you eat, with or without supplements, may be enough to keep your bones healthy. Doctors may recommend higher doses.
Category | Calcium: (RDA) |
0-6 months | 200 mg/day |
7-12 months | 260 mg/day |
1-3 years | 700 mg/day |
4-8 years | 1,000 mg/day |
9-18 years | 1,300 mg/day |
19-50 years | 1,000 mg/day |
51- 70 years | 1,200 mg/day (women) 1,000 mg/day (men) |
70+ years | 1,200 mg/day |
Women who are pregnant or breastfeeding don’t need amounts beyond the recommendations above.
The tolerable upper intake levels (ULs) of a supplement are the highest amount that most people can take safely. For calcium, it’s:
- Infants 0-6 months: 1,000 mg/day
- Infants 7-12 months: 1,500 mg/day
- Children 1-8 years: 2,500 mg/day
- Children/teens 9-18 years: 3,000 mg/day
- Adults 19-50 years: 2,500 mg/day
- Adults over 51 years: 2,000 mg/day
In general, it’s best to take calcium supplements with food. For better absorption, don’t take more than 500 milligrams at one time. Split up larger doses over the course of the day. For your body to make use of calcium properly, you also need to get enough vitamin D and magnesium.
Good sources of calcium include:
- Milk
- Cheese
- Yogurt
- Broccoli, kale, and Chinese cabbage
- Fortified cereals, juices, soy products, and other foods
- Tofu
Experts say that most adults in the U.S. don’t get enough calcium. While improving your diet will help, you may need to take calcium supplements.
You may want to talk to your doctor about calcium supplements and the best way to take them if you:
- Follow a vegan diet
- Can’t digest lactose (you’re lactose intolerant)
- Eat or drink a lot of protein or sodium, which can cause your body to get rid of more calcium
- Have thin, weak bones (osteoporosis)
- Take long-term corticosteroid treatments
- Have bowel or digestive diseases and can’t absorb calcium well
- Side effects. At normal doses, calcium supplements may cause bloating, gas, and constipation. Very high doses of calcium can cause kidney stones. Some studies show taking calcium supplements in addition to a diet high in calcium could raise your risk of heart attacks and strokes, but other experts disagree.
- Interactions. If you take any prescription or over-the-counter medicines regularly, ask your doctor if it’s safe to use calcium supplements. Calcium can interact with drugs for heart disease, diabetes, epilepsy, and other conditions. High doses of vitamin D can result in dangerously high levels of calcium. High doses of calcium can also prevent your body from absorbing minerals like iron and zinc. In general, take calcium one to two hours apart from other supplements or medications. If you take them at the same time, calcium can bind to those products, and they’ll pass from your body unabsorbed.
- Risks. If you have kidney disease, heart problems, sarcoidosis, or bone tumors, don’t take calcium supplements unless your doctor suggests them.
- Overdose. High levels of calcium in your blood can cause nausea, dry mouth, belly pain, an irregular heartbeat, confusion, and even death.
There’s no need to use products identified as “coral calcium.” Claims made that coral calcium is better than regular calcium are unproven. Also, coral calcium products may contain dangerous amounts of lead.
Top Picks
Calcium-D3-MIC – instructions for use, doses, side effects, reviews of the drug: capsules, 166.
7 mg + 66.7 IU
Analogs
Order in pharmacies
Order
drug
All forms of release, dosages, registration certificates, drug manufacturers, drug characteristics
Calcium-D3-MIC (capsules, 166.7 mg + 66.7 IU), instructions for medical use RU No. LSR-000019/09
Date last modified: 04/29/2021
Contents
- Active substance
- ATX
- Nosological classification (ICD-10)
- Pharmacological group
- Dosage form
- Compound
- pharmachologic effect
- Description of the dosage form
- Pharmacokinetics
- Indications
- Contraindications
- Use during pregnancy and lactation
- Dosage and administration
- Side effects
- Interaction
- Overdose
- special instructions
- Release form
- Terms of dispensing from pharmacies
- Storage conditions
- Best before date
- Order in Moscow pharmacies
- Reviews
Active ingredient
Calcium carbonate + Colecalciferol (Calcium carbonate + Colecalciferol)
ATX
A12AX Calcium preparations in combination with vitamin D and/or other preparations
Nosological classification (ICD-10)
ICD-10 code list
- E55 Vitamin D deficiency
- E58 Nutritional calcium deficiency
- M80. 9 Osteoporosis with pathological fracture, unspecified
- M81.9Osteoporosis, unspecified
Pharmacological group
Bone and cartilage metabolism correctors in combinations
Vitamins and vitamin-like products in combinations
Dosage form
Capsules.
Composition
1
capsule contains:
Active ingredients:
Calcium
carbonate – 416.3 mg (in terms of calcium – 166.7 mg),
colecalciferol type 100 CWS – 0.667 mg (in terms of
colecalciferol – 0.001667 mg (66.7 IU)).
Composition
cholecalciferol type 100 CWS: cholecalciferol crystalline, α‑tocopherol,
soybean oil, corn starch, hydrolyzed gelatin, sucrose.
Excipient:
Starch
potato.
Composition of the gelatin capsule shell:
Composition
hard gelatin capsule bodies: gelatin, purified water, titanium dioxide
E171; composition of the cap of a hard gelatin capsule: gelatin, purified water,
titanium dioxide E171, alluring red dye E129, dye
quinoline yellow E104.
Combined
drug, the action of which is due to its constituent components.
Regulates the exchange of calcium and phosphate ions, reduces resorption and increases
bone density, compensates for the lack of calcium ions and vitamin D 3
in the body, enhances the absorption of calcium ions in the intestine and reabsorption
phosphate in the kidneys, promotes bone mineralization.
Calcium
carbonate is involved in the formation of bone tissue, blood clotting,
in maintaining stable cardiac activity, in the implementation of processes
transmission of nerve impulses. Application of calcium and vitamin D 3
prevents an increase in the production of parathyroid hormone, which is
stimulator of increased bone resorption.
Description of dosage form
Capsules
hard, gelatinous No. 0 cylindrical shape with hemispherical ends
with white body and orange lid.
Content
capsules – powder of white or almost white color.
Pharmacokinetics
Vitamin D 3
absorbed in the small intestine. Calcium is absorbed in ionized form
in the proximal small intestine through active
transport mechanism.
Readings
–
Prevention and
treatment and deficiency of calcium and/or vitamin D 3 .
–
With insufficient
intake of calcium and vitamin D 3 into the body against the background
malnutrition.
–
With increased
body needs for calcium and vitamin D 3
during pregnancy and breastfeeding, as well as in children over 12
years during a period of intensive growth.
–
Prevention and
as part of the complex therapy of osteoporosis (menopausal, senile,
“steroid”, idiopathic, etc. ).
Contraindications
–
Hypercalcemia
(increased concentration of calcium in the blood).
–
Hypercalciuria
(increased calcium in the urine).
–
Nephurolithiasis.
–
Hypervitaminosis
vitamin D 3 .
–
Increased
sensitivity to the components of the drug.
–
severe renal
failure.
–
active form
tuberculosis.
–
Sarcoidosis.
–
Osteoporosis,
caused by immobilization.
–
Urolithiasis
disease.
–
Atherosclerosis.
–
Childhood
up to 12 years old.
With caution
Renal
insufficiency, benign granulomatosis, taking glycosides and thiazide
diuretics, pregnancy, lactation.
Use in pregnancy and lactation
Daily
the dose should not exceed 1500 mg calcium and 600 IU vitamin D 3 .
Hypercalcemia developing against the background of an overdose during pregnancy
can cause defects in the mental and physical development of the child.
Vitamin D 3
and its metabolites can pass into breast milk, therefore, it is necessary to take into account
intake of calcium and vitamin D 3 from other sources in the mother
and child. An overdose during pregnancy may lead to
mental and physical development of the child.
Dosage and Administration
Information for healthcare professionals only.
Are you a healthcare professional?
Adults and children over 12:
2-3 capsules 2 times a day, morning and evening, mainly
while eating.
Side effects
Allergic
reactions, dysfunction of the gastrointestinal tract (constipation or diarrhea, flatulence,
nausea, abdominal pain), hypercalcemia and hypercalciuria (increased
calcium in blood or urine).
Interactions
Information for healthcare professionals only.
Are you a healthcare professional?
Activity
vitamin D 3 may decrease when used simultaneously with phenytoin
or barbiturates.
At
simultaneous treatment with cardiac glycosides requires ECG monitoring and
clinical condition, since calcium preparations can potentiate
therapeutic and toxic effects of cardiac glycosides.
Preparations
calcium and vitamin D 3 may increase absorption
tetracyclines from the gastrointestinal tract. Therefore, the time interval
between taking a tetracycline drug and Calcium-D3-MIC should
be at least 3 hours.
For
to prevent a decrease in the absorption of bisphosphonates or sodium fluoride drugs,
it is recommended to take Calcium-D3-MIC not earlier than 2 hours later
after taking them.
Glucocorticosteroids
reduce calcium absorption, so treatment with glucocorticosteroids may
require an increase in the dose of Calcium-D3-MIC.
Simultaneous
treatment with Kolestyramine preparations or laxatives based on
mineral or vegetable oils can reduce the absorption of vitamin D 3 .
At
the simultaneous use of thiazide diuretics increases the risk
the occurrence of hypercalcemia, because they increase tubular
calcium reabsorption. Furosemide and other loop diuretics, on the other hand,
increase the excretion of calcium by the kidneys.
U
patients who are simultaneously taking cardiac glycosides and / or diuretics,
it is necessary to control the concentration of calcium and creatinine in the blood serum.
Overdose
Overdose symptoms:
Anorexia,
thirst, polyuria, decreased appetite, dizziness, fainting,
weakness, nausea, vomiting, hypercalciuria, hypercalcemia, hypercreatinemia.
With prolonged use, calcification of blood vessels and tissues.
Treatment:
Introduction
in the body of a large amount of fluid, the use of loop diuretics
(e.g. Furosemide), glucocorticosteroids, calcitonin, bisphosphonates. When
Seek medical attention if signs of overdose are detected.
Special instructions
B
during the treatment period, it is necessary to constantly monitor the excretion of calcium ions in the urine
and the concentration of calcium and creatinine ions in plasma (in case of development
calciuria exceeding 7. 5 mmol/day (300 mg/day)
reduce dose or stop taking).
Vo
to avoid overdose, additional intake must be taken into account
vitamin D 3 from other sources.
Reception
foods containing oxalates (sorrel, spinach) and phytin (cereals) reduces
calcium absorption, so you should not take Calcium-D3-MIC for
two hours after taking sorrel, spinach, cereals.
Product form
Capsules.
By
10 capsules in a blister pack, 6 blister packs
together with instructions for use are placed in a pack of cardboard.
Terms of dispensing from pharmacies
Without
doctor’s prescription.
Storage conditions
Store
in a place protected from moisture and light at a temperature of 15 ° C
up to 25 °С.
Store
in a place inaccessible to children.
Expiry date
2
of the year.
Not
use after the expiration date.
Update date: 10/31/2022
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The information provided on drug prices is not an offer to sell or buy goods.
The information is intended solely for comparing prices in stationary pharmacies operating in
in accordance with Article 55 of the Federal Law “On the Circulation of Medicines” dated April 12, 2010 No. 61-FZ.
Reviews
Read all reviews and leave your own.
Information for healthcare professionals only.
Are you a healthcare professional?
Calcium-D3-MIC – instructions for use, doses, side effects, reviews of the drug: capsules, 166.7 mg + 66.7 IU
Analogs
Order in pharmacies
Order
drug
All forms of release, dosages, registration certificates, drug manufacturers, drug characteristics
Calcium-D3-MIC (capsules, 166.7 mg + 66.7 IU), instructions for medical use RU No. LSR-000019/09
Date last modified: 04/29/2021
Contents
- Active substance
- ATX
- Nosological classification (ICD-10)
- Pharmacological group
- Dosage form
- Compound
- pharmachologic effect
- Description of the dosage form
- Pharmacokinetics
- Indications
- Contraindications
- Use during pregnancy and lactation
- Dosage and administration
- Side effects
- Interaction
- Overdose
- special instructions
- Release form
- Terms of dispensing from pharmacies
- Storage conditions
- Best before date
- Order in Moscow pharmacies
- Reviews
Active ingredient
Calcium carbonate + Colecalciferol (Calcium carbonate + Colecalciferol)
ATX
A12AX Calcium preparations in combination with vitamin D and/or other preparations
Nosological classification (ICD-10)
ICD-10 code list
- E55 Vitamin D deficiency
- E58 Nutritional calcium deficiency
- M80. 9 Osteoporosis with pathological fracture, unspecified
- M81.9Osteoporosis, unspecified
Pharmacological group
Bone and cartilage metabolism correctors in combinations
Vitamins and vitamin-like products in combinations
Dosage form
Capsules.
Composition
1
capsule contains:
Active ingredients:
Calcium
carbonate – 416.3 mg (in terms of calcium – 166.7 mg),
colecalciferol type 100 CWS – 0.667 mg (in terms of
colecalciferol – 0.001667 mg (66.7 IU)).
Composition
cholecalciferol type 100 CWS: cholecalciferol crystalline, α‑tocopherol,
soybean oil, corn starch, hydrolyzed gelatin, sucrose.
Excipient:
Starch
potato.
Composition of the gelatin capsule shell:
Composition
hard gelatin capsule bodies: gelatin, purified water, titanium dioxide
E171; composition of the cap of a hard gelatin capsule: gelatin, purified water,
titanium dioxide E171, alluring red dye E129, dye
quinoline yellow E104.
Combined
drug, the action of which is due to its constituent components.
Regulates the exchange of calcium and phosphate ions, reduces resorption and increases
bone density, compensates for the lack of calcium ions and vitamin D 3
in the body, enhances the absorption of calcium ions in the intestine and reabsorption
phosphate in the kidneys, promotes bone mineralization.
Calcium
carbonate is involved in the formation of bone tissue, blood clotting,
in maintaining stable cardiac activity, in the implementation of processes
transmission of nerve impulses. Application of calcium and vitamin D 3
prevents an increase in the production of parathyroid hormone, which is
stimulator of increased bone resorption.
Description of dosage form
Capsules
hard, gelatinous No. 0 cylindrical shape with hemispherical ends
with white body and orange lid.
Content
capsules – powder of white or almost white color.
Pharmacokinetics
Vitamin D 3
absorbed in the small intestine. Calcium is absorbed in ionized form
in the proximal small intestine through active
transport mechanism.
Readings
–
Prevention and
treatment and deficiency of calcium and/or vitamin D 3 .
–
With insufficient
intake of calcium and vitamin D 3 into the body against the background
malnutrition.
–
With increased
body needs for calcium and vitamin D 3
during pregnancy and breastfeeding, as well as in children over 12
years during a period of intensive growth.
–
Prevention and
as part of the complex therapy of osteoporosis (menopausal, senile,
“steroid”, idiopathic, etc. ).
Contraindications
–
Hypercalcemia
(increased concentration of calcium in the blood).
–
Hypercalciuria
(increased calcium in the urine).
–
Nephurolithiasis.
–
Hypervitaminosis
vitamin D 3 .
–
Increased
sensitivity to the components of the drug.
–
severe renal
failure.
–
active form
tuberculosis.
–
Sarcoidosis.
–
Osteoporosis,
caused by immobilization.
–
Urolithiasis
disease.
–
Atherosclerosis.
–
Childhood
up to 12 years old.
With caution
Renal
insufficiency, benign granulomatosis, taking glycosides and thiazide
diuretics, pregnancy, lactation.
Use in pregnancy and lactation
Daily
the dose should not exceed 1500 mg calcium and 600 IU vitamin D 3 .
Hypercalcemia developing against the background of an overdose during pregnancy
can cause defects in the mental and physical development of the child.
Vitamin D 3
and its metabolites can pass into breast milk, therefore, it is necessary to take into account
intake of calcium and vitamin D 3 from other sources in the mother
and child. An overdose during pregnancy may lead to
mental and physical development of the child.
Dosage and Administration
Information for healthcare professionals only.
Are you a healthcare professional?
Adults and children over 12:
2-3 capsules 2 times a day, morning and evening, mainly
while eating.
Side effects
Allergic
reactions, dysfunction of the gastrointestinal tract (constipation or diarrhea, flatulence,
nausea, abdominal pain), hypercalcemia and hypercalciuria (increased
calcium in blood or urine).
Interactions
Information for healthcare professionals only.
Are you a healthcare professional?
Activity
vitamin D 3 may decrease when used simultaneously with phenytoin
or barbiturates.
At
simultaneous treatment with cardiac glycosides requires ECG monitoring and
clinical condition, since calcium preparations can potentiate
therapeutic and toxic effects of cardiac glycosides.
Preparations
calcium and vitamin D 3 may increase absorption
tetracyclines from the gastrointestinal tract. Therefore, the time interval
between taking a tetracycline drug and Calcium-D3-MIC should
be at least 3 hours.
For
to prevent a decrease in the absorption of bisphosphonates or sodium fluoride drugs,
it is recommended to take Calcium-D3-MIC not earlier than 2 hours later
after taking them.
Glucocorticosteroids
reduce calcium absorption, so treatment with glucocorticosteroids may
require an increase in the dose of Calcium-D3-MIC.
Simultaneous
treatment with Kolestyramine preparations or laxatives based on
mineral or vegetable oils can reduce the absorption of vitamin D 3 .
At
the simultaneous use of thiazide diuretics increases the risk
the occurrence of hypercalcemia, because they increase tubular
calcium reabsorption. Furosemide and other loop diuretics, on the other hand,
increase the excretion of calcium by the kidneys.
U
patients who are simultaneously taking cardiac glycosides and / or diuretics,
it is necessary to control the concentration of calcium and creatinine in the blood serum.
Overdose
Overdose symptoms:
Anorexia,
thirst, polyuria, decreased appetite, dizziness, fainting,
weakness, nausea, vomiting, hypercalciuria, hypercalcemia, hypercreatinemia.
With prolonged use, calcification of blood vessels and tissues.
Treatment:
Introduction
in the body of a large amount of fluid, the use of loop diuretics
(e.g. Furosemide), glucocorticosteroids, calcitonin, bisphosphonates. When
Seek medical attention if signs of overdose are detected.
Special instructions
B
during the treatment period, it is necessary to constantly monitor the excretion of calcium ions in the urine
and the concentration of calcium and creatinine ions in plasma (in case of development
calciuria exceeding 7. 5 mmol/day (300 mg/day)
reduce dose or stop taking).
Vo
to avoid overdose, additional intake must be taken into account
vitamin D 3 from other sources.
Reception
foods containing oxalates (sorrel, spinach) and phytin (cereals) reduces
calcium absorption, so you should not take Calcium-D3-MIC for
two hours after taking sorrel, spinach, cereals.
Product form
Capsules.
By
10 capsules in a blister pack, 6 blister packs
together with instructions for use are placed in a pack of cardboard.
Terms of dispensing from pharmacies
Without
doctor’s prescription.
Storage conditions
Store
in a place protected from moisture and light at a temperature of 15 ° C
up to 25 °С.
Store
in a place inaccessible to children.
Expiry date
2
of the year.
Not
use after the expiration date.
Update date: 10/31/2022
Order in pharmacies
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