Uses, Side Effects, Interactions & Pill Images

• 
  PRD01012: This medicine is a pinkish-red light beige, oval, translucent, capsule imprinted with “RPC 053”.

• 
  PRD01060: This medicine is a red, round, tablet imprinted with “P 054”.

• 
  PRD01110: This medicine is a yellowish-tan, oval, capsule imprinted with “CLR 50”.

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

This medication is used to treat occasional constipation. Some medications and conditions can make constipation more likely. Stool softeners such as docusate are often the first method used for preventing and treating this type of constipation. Docusate is often used when straining to have a bowel movement should be avoided (e.g., after a heart attack or surgery).Docusate is a stool softener. It works by increasing the amount of water the stool absorbs in the gut, making the stool softer and easier to pass.

Follow all directions on the product package unless otherwise directed by your doctor. If you have any questions, ask your doctor or pharmacist.Take this medication by mouth, usually at bedtime with a full glass (8 ounces or 240 milliliters) of water or juice, or as directed by your doctor. The dosage is based on your medical condition and response to therapy. Decrease your dose or stop taking this medication if you develop diarrhea.If you are using the liquid form of this medication, measure the dose carefully using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose. If you are using the drops, measure the medication with the dropper provided, or use a dose-measuring spoon or device to make sure you have the correct dose. Mix the syrup, liquid or drops in 4 to 8 ounces of fruit juice, milk or infant formula to prevent throat irritation and mask a bitter taste.Use this medication only when needed. Do not use this product for more than 1 week unless directed by your doctor.Relief is usually seen in 1 to 3 days.Inform your doctor if your condition persists or worsens.

Stomach pain, diarrhea, or cramping may occur. Irritated throat (with liquid or syrup forms) may also occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.If your doctor has directed you to use this medication, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor right away if this unlikely but serious side effect occurs: rectal bleeding.A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Before taking this medication, tell your doctor or pharmacist if you are allergic to it or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.If you have any of the following health problems, consult your doctor or pharmacist before using this medication: severe abdominal pain, nausea, vomiting, sudden change in bowel habits over the previous 2 weeks.During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.It is not known if this drug passes into breast milk. Consult your doctor before breast-feeding.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.Some products that may interact with this drug include: mineral oil, drugs containing phenolphthalein.

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Do not share this medication with others.Constipation can usually be prevented by eating a diet high in fiber, drinking enough fluids and getting regular exercise. Use this medication for temporary relief of constipation only. Do not use this medication for a long period of time to prevent becoming dependent on laxatives.

If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature at 59-86 degrees F (15-30 degrees C) in a tightly closed container away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Information last revised September 2021. Copyright(c) 2021 First Databank, Inc.

Colace, DSS (docusate) dosing, indications, interactions, adverse effects, and more

DOCUSATE – ORAL

(DOCK-you-sate)

COMMON BRAND NAME(S): Col-Rite, Colace, Correctol, Diocto, Doc-Q-Lace, Docusoft, DSS, Silace, Surfak

USES: This medication is used to treat occasional constipation. Some medications and conditions can make constipation more likely. Stool softeners such as docusate are often the first method used for preventing and treating this type of constipation. Docusate is often used when straining to have a bowel movement should be avoided (e.g., after a heart attack or surgery).Docusate is a stool softener. It works by increasing the amount of water the stool absorbs in the gut, making the stool softer and easier to pass.

HOW TO USE: Follow all directions on the product package unless otherwise directed by your doctor. If you have any questions, ask your doctor or pharmacist.Take this medication by mouth, usually at bedtime with a full glass (8 ounces or 240 milliliters) of water or juice, or as directed by your doctor. The dosage is based on your medical condition and response to therapy. Decrease your dose or stop taking this medication if you develop diarrhea.If you are using the liquid form of this medication, measure the dose carefully using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose. If you are using the drops, measure the medication with the dropper provided, or use a dose-measuring spoon or device to make sure you have the correct dose. Mix the syrup, liquid or drops in 4 to 8 ounces of fruit juice, milk or infant formula to prevent throat irritation and mask a bitter taste.Use this medication only when needed. Do not use this product for more than 1 week unless directed by your doctor. Relief is usually seen in 1 to 3 days.Inform your doctor if your condition persists or worsens.

SIDE EFFECTS: Stomach pain, diarrhea, or cramping may occur. Irritated throat (with liquid or syrup forms) may also occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.If your doctor has directed you to use this medication, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor right away if this unlikely but serious side effect occurs: rectal bleeding.A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking this medication, tell your doctor or pharmacist if you are allergic to it or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.If you have any of the following health problems, consult your doctor or pharmacist before using this medication: severe abdominal pain, nausea, vomiting, sudden change in bowel habits over the previous 2 weeks.During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.It is not known if this drug passes into breast milk. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.Some products that may interact with this drug include: mineral oil, drugs containing phenolphthalein.

OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

NOTES: Do not share this medication with others.Constipation can usually be prevented by eating a diet high in fiber, drinking enough fluids and getting regular exercise. Use this medication for temporary relief of constipation only. Do not use this medication for a long period of time to prevent becoming dependent on laxatives.

MISSED DOSE: If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.

STORAGE: Store at room temperature at 59-86 degrees F (15-30 degrees C) in a tightly closed container away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Information last revised September 2021. Copyright(c) 2021 First Databank, Inc.

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

Memorial Sloan Kettering Cancer Center

This information from Lexicomp^® explains what you need to know about this medication, including what it’s used for, how to take it, its side effects, and when to call your healthcare provider.

Brand Names: US

Colace [OTC]; Diocto [OTC] [DSC]; DocQLace [OTC] [DSC]; Docu Liquid [OTC]; Docu Soft [OTC] [DSC]; Docu [OTC]; Docuprene [OTC] [DSC]; Docusate Mini [OTC]; Docusil [OTC] [DSC]; DocuSol Kids [OTC]; DocuSol Mini [OTC]; DOK [OTC]; Dulcolax Stool Softener [OTC]; Enemeez Mini [OTC]; GoodSense Stool Softener [OTC] [DSC]; Healthy Mama Move It Along [OTC]; Kao-Tin [OTC] [DSC]; KS Stool Softener [OTC] [DSC]; Laxa Basic [OTC] [DSC]; Pedia-Lax [OTC]; Promolaxin [OTC] [DSC]; Silace [OTC]; Sof-Lax [OTC] [DSC]; Stool Softener [OTC]

What is this drug used for?

• It is used to treat constipation.

What do I need to tell my doctor BEFORE I take this drug?

• If you are allergic to this drug; any part of this drug; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
• If you have any of these health problems: Bowel block, belly pain, upset stomach, rectal bleeding, throwing up, or change in bowel habits lasting longer than 2 weeks.
• If you are taking mineral oil.

This is not a list of all drugs or health problems that interact with this drug.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take this drug?

• Tell all of your health care providers that you take this drug. This includes your doctors, nurses, pharmacists, and dentists.
• Do not use this drug for more than 1 week unless told to do so by your doctor.
• If you have rectal bleeding or you do not have a bowel movement after using this drug, talk with your doctor.
• Do not use other laxatives or stool softeners unless told to do so by the doctor.
• If you are on a low-sodium or sodium-free diet, talk with your doctor. Some of these products have sodium.
• Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. You will need to talk about the benefits and risks to you and the baby.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

All products:

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.

Rectal enema:

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

All oral products:

• Stomach cramps.
• Diarrhea.

Liquid:

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to your national health agency.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.

How is this drug best taken?

Use this drug as ordered by your doctor. Read all information given to you. Follow all instructions closely.

All oral products:

• Take with or without food.
• Take with a full glass of water.

Liquid:

• Mix liquid with milk, juice, or formula as you have been told to prevent throat irritation or cover the bitter taste.
• Measure liquid doses carefully. Use the measuring device that comes with this drug. If there is none, ask the pharmacist for a device to measure this drug.
• Some of these drugs need to be shaken before use. Be sure you know if this product needs to be shaken before using it.

Rectal enema:

• This drug is for rectal use only. Do not take this drug by mouth.
• Take off cap.
• Put a lubricant on the enema tip and on the anus before using this drug.
• Put enema tip into the rectum with gentle pressure. Do not force.
• Squeeze the bottle until almost all the liquid is gone.
• If the tip of the tube or this drug will not go into the rectum, do not force it. Call the doctor.

What do I do if I miss a dose?

• If you take this drug on a regular basis, take a missed dose as soon as you think about it.
• If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
• Do not take 2 doses at the same time or extra doses.
• Many times this drug is taken on an as needed basis. Do not take more often than told by the doctor.

How do I store and/or throw out this drug?

• Store at room temperature. Do not freeze.
• Store in a dry place. Do not store in a bathroom.
• Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
• Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

General drug facts

• If your symptoms or health problems do not get better or if they become worse, call your doctor.
• Do not share your drugs with others and do not take anyone else’s drugs.
• Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider.
• Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider.
• If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Consumer Information Use and Disclaimer

This generalized information is a limited summary of diagnosis, treatment, and/or medication information. It is not meant to be comprehensive and should be used as a tool to help the user understand and/or assess potential diagnostic and treatment options. It does NOT include all information about conditions, treatments, medications, side effects, or risks that may apply to a specific patient. It is not intended to be medical advice or a substitute for the medical advice, diagnosis, or treatment of a health care provider based on the health care provider’s examination and assessment of a patient’s specific and unique circumstances. Patients must speak with a health care provider for complete information about their health, medical questions, and treatment options, including any risks or benefits regarding use of medications. This information does not endorse any treatments or medications as safe, effective, or approved for treating a specific patient. UpToDate, Inc. and its affiliates disclaim any warranty or liability relating to this information or the use thereof. The use of this information is governed by the Terms of Use, available at https://www.wolterskluwer.com/en/solutions/lexicomp/about/eula.

Last Reviewed Date

2020-05-11

Copyright

© 2021 UpToDate, Inc. and its affiliates and/or licensors. All rights reserved.

Colace is a medication drug used soften stool for easing bowel movements.

Colace is a medication drug used to soften the stool for easing bowel movements. It prevents constipation as well as rectal damage caused by hardened stools. This drug works by facilitating the mixture of stool fat with water, thus making it easier to pass through the intestine and rectum.

DOSAGE –

• Colace is to be taken as directed by the doctors.
• The oral capsule is to be consumed whole with a glass of water.
• This drug will cause a bowel movement within 12-72 hours after consumption.
• This drug is not to be used for more than 7 days.
• Pediatric dose:

Oral Capsule – 50 -150mg (over the course of four doses a day)

• General Adult Dosage available:

Oral capsule – 50 – 300mg (over the course of four doses a day)

SIDE EFFECTS –

• Dizziness
• Weakness
• Gas trouble
• Bloating
• Mild diarrhea
• Rectal irritation
• Sweating

RARE SIDE EFFECTS:

• Unusual palpitations
• Rectal bleeding
• Rashes around the rectum
• Vomiting
• Severe diarrhea
• Stomach cramps

DRUG INTERACTIONS –

• Lactulose
• Mineral oil
• Phenolphthalein
• Aluminum hydroxide / mineral oil
• Lanolin / mineral oil topical

Colace has no major drug interactions, but has moderate interactions with 10 different drugs, most of which are combined with mineral oil.

PRECAUTIONS –

• Provide the doctor with a detailed and accurate medical history prior to drug prescription. Notify especially in case of a low-salt diet or a sudden change in bowel habits as of recent.
• Do not use this drug in case of an allergy to the drug like nausea, vomiting or severe stomach pain during the time of consumption. In case of a blockage in the intestines or an unchecked chronic stomach pain, do not consume Colace until after the doctor has advised for it.

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Generic Name : DOCUSATE ABSTRACT – Colace is a medication drug used to soften the stool for easing bowel…

docusate (oral/rectal) | CS Mott Children’s Hospital

What is the most important information I should know about docusate?

You should not use docusate if you also use mineral oil, unless your doctor tells you to.

What is docusate?

Docusate is a stool softener that makes bowel movements softer and easier to pass.

Docusate is used to relieve occasional constipation (irregularity).

There are many brands and forms of docusate available. Not all brands are listed on this leaflet.

Docusate may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using docusate?

You should not use docusate if you are allergic to it.

Ask a doctor or pharmacist if this medicine is safe to use if you have:

• stomach pain;
• nausea;
• vomiting; or
• a sudden change in bowel habits that lasts over 2 weeks.

Ask a doctor before using this medicine if you are pregnant or breastfeeding.

Do not give this medicine to a child without medical advice.

How should I use docusate?

Use exactly as directed on the label, or as prescribed by your doctor.

Drink plenty of liquids while you are using docusate.

Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

Do not take the rectal enema by mouth. Rectal medicine is for use only in the rectum.

Wash your hands before and after using the enema.

To use the enema, lie on your left side with your left leg extended and your right leg slightly bent. Remove the cap from the applicator tip and gently insert the tip into your rectum. Slowly squeeze the bottle to empty the contents into the rectum.

After using the enema, lie down on your left side for at least 30 minutes to allow the liquid to distribute throughout your intestines. Avoid using the bathroom, and hold in the enema at least 1 hour, or all night if possible.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

Docusate generally produces bowel movement in 12 to 72 hours. Call your doctor if your symptoms do not improve after 72 hours.

You should not use docusate for longer than 1 week, unless your doctor tells you to.

Store at room temperature away from moisture and heat. Do not freeze liquid medicine.

What happens if I miss a dose?

Since docusate is used when needed, you may not be on a dosing schedule. Skip any missed dose if it’s almost time for your next dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using docusate?

Avoid using mineral oil, unless told to do so by a doctor.

What are the possible side effects of docusate?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using docusate and call your doctor at once if you have:

• rectal bleeding or irritation; or
• no bowel movement after 72 hours.

Less serious side effects may be more likely, and you may have none at all.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect docusate?

Other drugs may affect docusate, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your pharmacist can provide more information about docusate.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2021 Cerner Multum, Inc. Version: 4.01. Revision date: 7/8/2019.

Colace – Pharmasave – Pharmasave

For adults and children older than 12 years, the recommended dose ranges from 100 mg to 200 mg daily.

For children 6 to 12 years old, the recommended dose is 40 mg to 120 mg daily.

For children 3 to 6 years old, the recommended dose is 20 mg to 60 mg daily.

For children under 3 years of age, your doctor will recommend the appropriate dose.

Children under 6 years of age should not be given this medication unless recommended by a doctor.

Swallow the capsules whole with water or fruit juice. The syrup or drops should be given in 120 mL (about ½ cup) of milk or fruit juice, or in infant formula to mask the bitter taste of the medication. Use an oral syringe or dropper to measure each dose of the syrup or drops.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature; protect it from light, moisture, and freezing; and keep it out of the reach of children.

This medication is available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms listed here. The forms available for the specific brand you have searched are listed under “What form(s) does this medication come in?”

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

docusate and senna | Von Voigtlander Women’s Hospital

What is the most important information I should know about docusate and senna?

Use exactly as directed on the label, or as prescribed by your doctor.

What is docusate and senna?

Docusate is a stool softener. Senna is a laxative.

Docusate and senna is a combination medicine used to treat occasional constipation.

Docusate and senna may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using docusate and senna?

You should not use this medicine if you are allergic to docusate or senna, or if you are also taking mineral oil.

Ask a doctor or pharmacist if this medicine is safe to use if you have ever had:

• nausea or vomiting;
• stomach pain;
• a sudden change in bowel habits that lasts for 2 weeks or longer; or
• an intestinal disorder such as Crohn’s disease or ulcerative colitis.

Ask a doctor before using this medicine if you are pregnant or breastfeeding.

Do not give this medicine to a child younger than 2 years old without medical advice.

How should I use docusate and senna?

Use exactly as directed on the label, or as prescribed by your doctor.

Take docusate and senna with a full glass of water.

It may be best to take this medicine at night or at bedtime. Docusate and senna should cause you to have a bowel movement within 6 to 12 hours.

Do not take docusate and senna for longer than 7 days in a row, unless your doctor tells you to.

Call your doctor if your constipation does not improve or if it gets worse after taking docusate and senna.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Since docusate and senna is used when needed, you may not be on a dosing schedule. Skip any missed dose if it’s almost time for your next dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include nausea, vomiting, stomach pain, or diarrhea.

What should I avoid while using docusate and senna?

Ask a doctor or pharmacist before using any other laxative or other stool softener that may contain ingredients similar to docusate or senna.

What are the possible side effects of docusate and senna?

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using docusate and senna and call your doctor at once if you have:

• rectal bleeding;
• severe stomach pain, nausea, vomiting; or
• no bowel movement.

Common side effects may include:

• gas, bloating;
• diarrhea; or
• mild nausea.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect docusate and senna?

Other drugs may affect docusate and senna, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your pharmacist can provide more information about docusate and senna.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2021 Cerner Multum, Inc. Version: 3.01. Revision date: 9/17/2020.

90,000 Colace vs. Dulcolax: Differences, Similarities, and What’s Best for You – Drug Vs. Friend

Drug Vs. Friend

Drug Review and Main Differences | Treatment conditions | Efficiency | Insurance coverage and cost comparison | Side Effects | Drug Interactions | Warnings | Frequently Asked Questions

Colace and Dulcolax are two over-the-counter medications that can help treat constipation. Constipation is a gastrointestinal disorder characterized by three or fewer bowel movements per week, hard or lumpy stools, difficult stools, or a feeling that the stool has not cleared completely.Bowel habits do differ from person to person. Constipated patients may describe a feeling of bloating or pressure in the intestines.

Constipation is common and can affect infants, children and adults. An estimated 16 out of every 100 Americans are constipated. There are certain groups of patients who are more likely to suffer from constipation. These include the elderly, women, non-European people, patients on a low fiber diet, and patients on certain other medications.

While this article only compares Kolas and Dulcolax, there are obviously many OTC laxatives out there. Talk with your doctor to determine which laxative is right for you.

What are the main differences between Kolas and Dulcolax?

Colace (sodium docusate) is an over-the-counter medicine used to treat and relieve symptoms of constipation. Colace acts as a surfactant and reduces the surface tension of oil and water in the stool.This allows lipids and moisture to enter the stool, creating softer stools that can move more easily through the gastrointestinal tract. Colace is classified as a stool softener but is not considered a laxative because it does not directly stimulate motor skills. It can take one to three days to soften the stool, so Colace does not usually provide quick relief from constipation symptoms. Colace is available in 50 and 100 mg softgels and 10 and 60 mg / 15 ml oral solutions.There are also glycerin suppositories and combinations of stool softeners and laxatives available under the trade name Colace.

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Dulcolax (bisacodyl EC) is an over-the-counter drug used to treat and relieve symptoms of constipation. Dulcolax is a laxative that directly stimulates peristalsis by irritating the intestinal mucosa.This stimulation physically moves the stool down the tract. Dulcolax produces the desired effect faster than Kolas, usually within 8-12 hours when taken orally. Dulcolax (what is Dulcolax?) Available in 5 and 10 mg enteric coated tablets, as well as in the form of 10 mg rectal suppositories. There are stool softeners and other products available under the brand name Dulcolax.

Diseases treated by Colas and Dulcolax

Colace is indicated both for the treatment of constipation and for its prevention. Occasional constipation should disappear within one week. Colace is generally safe to take over long periods of time under the direction of a doctor, and can be prescribed to prevent constipation associated with other medications or conditions known to cause constipation.

Dulcolax is indicated only in the treatment of occasional constipation. Its motor stimulation mechanism can cause some discomfort. It should be used for no more than one week unless otherwise advised by your doctor.

4

9011 Are Kolas or Dulcolax more effective?

The active ingredients Colace and Dulcolax have not been compared in direct comparison clinical trials for efficacy in the treatment of constipation.

When choosing a particular drug, several factors should be taken into account. One factor may be how quickly you expect relief. Dulcolax suppositories usually work for several hours, but may cause some discomfort. Dulcolax tablets usually provide relief overnight, for 8-12 hours. Colace may take one to three days to induce a bowel movement.

The dosage form is also an important factor. For some patients, administration of a rectal suppository may be difficult or more uncomfortable than they can stand.Although suppositories work quickly, patients may prefer an oral dosage form.

Only your doctor can decide what is right for you. Kolas and Dulcolax should not be taken for more than one week without your doctor’s consent.

Coverage and Cost Comparison for Colace and Dulcolax

Colace is an over-the-counter drug that is not usually covered by Medicare commercial or drug plans. On average, a bottle of Colace will cost over $ 15.If you have a prescription, you can pay as little as $ 4.26 with a coupon from SingleCare.

Get a SingleCare Prescription Loyalty Card

Dulcolax is an over-the-counter drug not usually covered by commercial drug plans or Medicare coverage. The average retail price for a pack of 12-item Dulcolax suppositories is nearly $ 12. You can pay as little as $ 6.10 with this coupon from SingleCare if you get a prescription from your healthcare provider.

Common Side Effects Colace vs.Dulcolax

Side effects are rare when taking Kolas. Mild gastrointestinal cramps may occur. At higher doses and / or prolonged use, diarrhea and loose stools may occur. The liquid preparation may irritate the throat lining if not diluted according to the manufacturer’s instructions.

Dulcolax at usual doses for a short period of treatment may cause mild gastrointestinal cramps, fainting, nausea and vomiting. Long-term use of Dulcolax can cause diarrhea and lead to fluid and electrolyte loss.This can lead to hypokalemia (low potassium levels), which can be dangerous. Prolonged use can also lead to dependence, and constipation may occur when the medication is stopped.

This list may not include all potential side effects. Consult your healthcare professional for a complete list.

Source: Colace (DailyMed) Dulcolax (DailyMed)

Dulcolaxa

Kolas and Dulcolax trail should be used with caution in patients taking loop diuretics such as furosemide or torsemide.These diuretics result in a loss of potassium, and this loss of potassium, combined with the potential electrolyte imbalance that can result from diarrhea while taking Kolace or Dulcolax, can lead to hypokalemia.

Colace should not be taken with mineral oil because it may increase the systemic absorption of the mineral oil. Inflammation of the intestines, liver, spleen and lymph nodes can result from deposits of mineral oil in these areas, leading to a foreign body reaction.

Dulcolax is enteric coated and designed for delayed dissolution. Taking Dulcolax with antacids, h3 blockers, and proton inhibitors may cause the enteric coating to dissolve prematurely, leading to stomach irritation or dyspepsia. Dulcolax should be separated from these drugs for at least one hour.

This is not an exhaustive list of potential drug interactions. For a complete list, check with your pharmacist or doctor.

Warnings Colace and Dul2colax

consult a doctor before using colace or dulcolax.You should also check with your doctor if you experience an abrupt change in bowel movements that has lasted more than two weeks.

When taking Dulcolax, abdominal cramps and discomfort may occur. Do not crush or chew Dulcolax tablets or take Dulcolax within one hour of taking antacids or milk. If you do not have a bowel movement or have rectal bleeding after taking Dulcolax, stop taking it and see your doctor.

Frequently Asked Questions about Colace vs. Dulcolax

What is Kolas?

Colace is an over-the-counter stool softener used to prevent and treat constipation. Colace is available in 50 and 100 mg softgels and 10 and 60 mg / 15 ml oral solutions.

What is Dulcolax?

Dulcolax is a stimulant laxative used in the treatment of occasional constipation. Dulcolax is available in enteric coated tablets of 5 and 10 mg, as well as in the form of rectal suppositories of 10 mg.

Are Kolas and Dulcolax the same thing?

Although both Colace and Dulcolax are used to treat constipation, they are not the same and act in different ways. Colace, a stool softener, helps soften stools and make them easier to pass. Dulcolax, a stimulant laxative, mimics the physical movement of stool through the digestive tract.

Kolas or Dulcolax is better?

Dulcolax causes a bowel movement faster than Kolas, with the suppository form acting for an hour or so after ingestion.Colace is usually softer and less discomforting, but it may take up to three days for relief.

Can I use Kolas or Dulcolax during pregnancy?

The Food and Drug Administration (FDA) has not assigned a pregnancy safety category to Colace. Kolas has been associated with some cases of fetal malformations, so it should only be used when the benefits clearly outweigh the risks. Dulcolax has not shown any side effects and is considered relatively safe for short-term use during pregnancy.The risk of dehydration and electrolyte imbalances should be weighed when deciding whether to treat constipation in pregnant women, and their healthcare provider should always be consulted.

Can I use Colas or Dulcolax with alcohol?

Although there is no direct interaction with alcohol, the effects of alcohol on the digestive system may increase the risk of dehydration, so caution should be exercised when taking Kolace or Dulcolax while drinking alcohol.

Is Dulcolax a chair softener?

Dulcolax formulations containing bisacodyl are considered stimulant laxatives and not stool softeners. There are chair softeners available under the brand name Dulcolax.

What is the difference between a stool softener and a laxative?

A stool softener reduces the surface tension of oil and water in the stool. This draws in extra moisture into the stool, making it softer and easier to pass. Laxatives act by physically increasing the motility of the digestive tract, which mechanically moves stool through the digestive tract.

Is it safe to take a stool softener every day?

Stool softeners may be taken every day under medical supervision to prevent and treat chronic constipation. It’s important to watch for signs of dehydration and ongoing diarrhea.

Stool Softener – instructions for use, dosage, composition, analogs, side effects / Pillintrip

Special warnings and precautions

Use Stool Softener syrup as directed by your doctor.Check the medicine label for exact dosing instructions.

• Take Stool Softener Syrup by mouth with or without food.
• Take Stool Softener Syrup with a full glass of water or other liquid (8 oz / 240 ml).
• Stool Softener Syrup can be mixed into half a glass of milk, fruit juice or infant formula before taking it.
• Use the measuring device marked for drug dispensing. Ask your pharmacist for help if you are not sure how to measure your dose.
• It is recommended to drink extra fluids while taking Stool Softener Syrup. See your doctor for instructions.
• Bowel movements usually occur 1–3 days after the first dose.
• If you miss taking Stool Softener Syrup and are taking it regularly, take it as soon as possible. If it’s almost time for your next dose, skip the missed dose and go back to your normal dosing schedule. Do not take 2 doses at the same time.

Ask your doctor any questions about how to use Stool Softener Syrup.

There are both specific and general uses for a drug or medicine. A medicine can be used to prevent a disease, treat a disease for a specified period, or treat a disease. It can also be used to treat a specific symptom of a disease. The use of the drug depends on the form the patient is taking. It may be more useful in injection form, or sometimes in tablet form. The drug can be used for a single alarming symptom or life-threatening condition.Although some medications can be discontinued after a few days, some medications must be continued for a long period of time in order to benefit from them.

This medication is used to treat occasional constipation. Certain medications and conditions can make constipation more likely. Stool softeners, such as a stool softener, are often the first method used to prevent and treat this type of constipation. A stool softener is often used when straining to avoid bowel movements (eg.after a heart attack or surgery).

The Softener stool is a stool softener. It works by increasing the amount of water that the stool absorbs into the intestines, making stools softer and easier to pass.

How to use Stool Softener (Stool Softener calcium)

Follow all directions on product packaging unless otherwise directed by your healthcare professional. If you are unsure of any information, ask your doctor or pharmacist.

Take this medication by mouth, usually at bedtime with a full glass (8 ounces or 240 milliliters) of water or juice, or as directed by a healthcare practitioner.Dosage is based on your medical condition and response to therapy. Reduce your dose or stop taking this medication if you develop diarrhea.

If you are using the liquid form of this medication, carefully measure the dose using a special measuring device / spoon. Do not use a homemade spoon because you may not get the correct dose. If you are using drops, measure the medicine with a dropper or use a dosing spoon or device to make sure you have the correct dose.Mix syrup, liquid, or drops in 4-8 ounces of fruit juice, milk, or infant formula to prevent throat irritation and mask the bitter taste.

Use this medication only as needed. Do not use this product for more than 1 week unless directed by your doctor.

Relief usually occurs in 1-3 days.

Tell your doctor if your condition persists or worsens.

Dokusat: side effects, dosages, treatment, interactions, warnings

Brand Name: Colace, DSS, Albert Docusate, Docusate Calcium, Sodium Docusate, DulcoEase, Phillips Liqui Gels, Silace, Soflax.

Generic Name: Docusate

Drug Class: Laxatives, Stool Softener

What is Docusate and how does it work?

Docusate is used to treat occasional constipation. Certain medications and conditions can make you more likely to be constipated. Stool softeners such as docusat are often the first method to prevent and treat this type of constipation. Dokusat is often used when overexertion of bowel movements should be avoided (for example, after a heart attack or surgery).

Dokusat is a stool softener. It works by increasing the amount of water absorbed by feces in the intestines, making stools softer and easier to pass.

Dokuzat is available under the following brand names: Colace, DSS, Albert Docusate, Docusate Calcium, Sodium Dokuzate, DulcoEase, Phillips Liqui Gels, Silace and Soflax.

What is Tylenol Generic

Docusate dosages:

Dosage forms for adults and children and their strengths

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Sodium capsule

• 50 mg
• 100 mg
• 250 mg

Calcium capsule

Tablet (for adults only)

Oral liquid

ml

Syrup

Enema, rectal (sodium)

• 100 mg / 5 ml (only for children)
• 283 mg (5 ml)

Recommended dosage:

Excessive consumption can lead to addiction.

Does Toradol make you feel high?

Laxative

Adult, Oral

• Sodium Dokusat: 50-300 mg orally once a day or in divided doses.
• Calcium Dokusat: 240 mg orally once a day.

Adult, Rectal

• 283 mg / 5 ml (1 enema) rectally one to three times a day

Pediatric, Oral

• Sodium Dokusat
• Children under 2 years of age: safety and efficacy not established …
• Children 2-12 years old: 50-150 mg orally once a day or in divided doses.
• Children over 12 years of age: 50-300 mg orally once a day or in divided doses.
• Calcium Dokusat
• Children under 12 years of age: Safety and efficacy have not been established.
• Children 12 years of age and older: 240 mg orally once a day.

Pediatric, Rectal

• Children under 2 years of age: Safety and efficacy have not been established.
• Children 2-12 years: 100 mg / 5 ml (1 enema) rectally once a day; alternatively 283 mg / 5 ml (1 enema) rectally once a day
• Children over 12 years of age: 283 mg / 5 ml (1 enema) rectally one to three times a day.

What side effects are associated with the use of Docusate?

Dokuzat side effects include:

• Abdominal cramps
• Abdominal pain
• Diarrhea
• Excessive bowel activity
• Intestinal obstruction
• Throat irritation
• Low electrolyte levels

Excessive use)

This document does not contain all the possible side effects that may occur.For more information on side effects, check with your doctor.

What other drugs interact with docusate?

If your doctor has advised you to use this medicine, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medication until after talking with your doctor, healthcare provider, or pharmacist.

which is used for the treatment of clopidogrel

Dokusat has no serious, serious or moderate interactions with other medicines.

Mild document interactions include:

This information does not include all possible interactions or side effects. Therefore, before using this product, tell your doctor or pharmacist about all the products you are using. Keep a list of all your medicines with you and share this information with your doctor and pharmacist.Check with your healthcare professional or healthcare professional for additional medical advice, or if you have any health questions, concerns, or more information about this medication.

What Warnings and Precautions for Docusate?

Warnings

• This medicine contains docusate. Do not take Colace, DSS, Albert Docusate, Docusate Calcium, Docusate Sodium, DulcoEase, Phillips Liqui Gels, Silace, or Soflax if you are allergic to Docusate or any of the ingredients in this drug.

Keep out of reach of children. In case of overdose, seek immediate medical attention or contact a Poison Control Center.

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Contraindications.

• Hypersensitivity
• Intestinal obstruction, symptoms of appendicitis or acute abdominal pain, stool blockage
• Concomitant use of mineral oil
• Nausea or vomiting
• Use for more than 7 days with self-medication
  0 Consequences of drug use can lead to dependence

Short-term effects

• “What are the side effects associated with using Docusate?”

Long term effects

• See “What side effects are associated with the use of Docusate?”

Warnings

• Electrolyte imbalance can occur with excessive use.
• Excessive use can lead to dependence
• Enema is for rectal use only; lubricate before administration; discontinue use and inform a healthcare professional if irritation develops around the anus / rectum or resistance occurs during insertion; trauma or damage to the rectum may occur if tubing
• Before use without a prescription, the patient should contact a healthcare professional if abdominal pain, nausea or vomiting is present, or if there is a sudden change in bowel habits that persists for 14 days.
• The patient should discontinue use and notify a healthcare professional if bleeding occurs, if bowel movement does not occur after use, or if use must be continued after use for 7 days

Pregnancy and lactation

• Use docusat with caution during pregnancy. if the benefits outweigh the risks. Animal studies show risk and human studies are not available or animal or human studies have not been done.
• It is not known whether docusate is excreted in milk; it is compatible with nursing.

References Medscape. Docusate.
https://reference.medscape.com/drug/colace-dss-docusate-342012
WebMD. Docusate.
https://www.webmd.com/drugs/2/drug-323/docusate-sodium-oral/details#side-effects
MedicineNet. Docusate.
https://www.medicinenet.com/docusate-oral/article.htm
90,000 What factors affect the dosage of Colace?

Colace®, which is a brand name for a drug containing the chemical sodium dioctyl sulfosuccinate, is commonly used in the treatment of bowel disease and stool softening.When used correctly, this drug can be very effective in relieving unwanted symptoms. A physician or healthcare professional must evaluate each patient to determine the appropriate dosage of Colace® and whether the drug is appropriate for the person and situation. There are a number of factors that affect the dose prescribed, including age, weight, medical history, and the nature of the underlying medical condition.

Colace® is usually prescribed by healthcare professionals for constipation or other ailments that require softening of the stool.When the stool becomes softer, it is easier to pass. One factor that can affect the dosage of Colace® prescribed by the supplier is age. The general rule of thumb is that the younger the person, the lower the dose of Colace®. Children under the age of three will be examined individually, children between the ages of three and six should be given 20 to 60 mg per day, children aged six to 12 are usually given a dose of Colace® 40 to 120 mg per day and for people over 12 years old, the standard dose of this stool softener can be between 100 and 200 mg per day.

Again, these dosages may vary depending on other factors or the prescribing provider and are intended to give more baseline dosages than accurate measurements. These doses are also not necessarily consumed immediately, but can be distributed regularly throughout the day throughout the day. For example, a Colace® 200 mg dose can be divided into four 50 mg tablets, eight 25 mg tablets, or two 100 mg tablets. There can be advantages and disadvantages of these various increments that should be considered by the healthcare provider.

Weight can also play a role in determining the appropriate dosage of Colace®. The heavier the person, the more diluted the medicine becomes due to the greater mass and volume of the tissue. This is one of the reasons why children can only tolerate lower doses, as their overall body size is smaller than that of the average person.

Depending on other drugs the person may be taking, he or she may need to increase or decrease the dosage of Colace®. Some medications increase the effects, while others can reduce them.These interactions can also cause changes in the appropriate amount of stool softener needed to treat a person’s condition.

OTHER LANGUAGES

90,000 Amitiz: side effects, dosage, cost and more

What is Amitiza?

Amitiza (lubiprostone) is a prescription drug brand. It is used to treat three types of constipation in adults:

• chronic idiopathic constipation (CIC)
• Irritable bowel syndrome with constipation (IBS-C) in women
• opioid-induced constipation (OIC) in people taking opioid drugs for long-term non-cancer pain

Amitiza is a medicine called a chloride channel activator.It is not a stool softener, fiber type, or traditional laxative. However, it produces the same effects as other treatments. This increases the fluid in your intestines, which helps the stool pass.

Amitiza is available as an oral capsule that you take with food and water. It is usually taken twice a day. You should take it for as long as your doctor recommends.

efficiency

Clinical studies have shown that Amitiza is effective in treating all three types of constipation for which it is prescribed:

• Chronic idiopathic constipation (CIC) .In clinical studies, about 57-63% of people taking Amitiza experienced a bowel movement within the first day of taking the drug.
• Irritable Bowel Syndrome with Constipation (IBS-C): Symptoms were improved in two different clinical studies in women with IBS-C who took Amitiza, including reduced abdominal pain and discomfort. 12 to 14 percent of women taking Amitiza responded to treatment. This means that they had a significant improvement in their symptoms and did not need to take laxatives or other medications to treat constipation.
• Opioid constipation (OIC) . Clinical studies of people with OIC showed that those who took Amitiza experienced an improvement in the number of bowel movements. Between 13 and 27 percent of people taking Amitiza responded to treatment. This means that they had at least three bowel movements per week and one more bowel movement per week than before taking the drug.

Amitiza generic

Amitiza is only available as a brand name drug. It contains the drug lubiprostone, which is not currently available in generic form.

Amitiza side effects

Amitisa may cause mild to serious side effects. The following list contains some of the key side effects that can occur while taking Amitiz. This list does not include all possible side effects.

For more information on the possible side effects of Amitiza, or tips on how to deal with an unpleasant side effect, talk to your doctor or pharmacist.

More common side effects

The most common side effects of Amitiza may include:

• Headache
• abdominal pain
• diarrhea
• gas and bloating
• nausea
• dizziness
• breathing problems (usually resolves in a few hours)

Most of these side effects may disappear within a few days or weeks.If they are more severe or persist, talk to your doctor or pharmacist.

Serious side effects

Serious side effects from Amitiza are not common, but they can occur. If you have any serious side effects, call your doctor right away. Call 911 if your symptoms appear to be life-threatening or if you think you have a medical emergency.

Serious side effects and their symptoms may include the following:

• Allergic reaction.Symptoms may include:

  • itching or urticaria
  • swelling on your face or hands
  • swelling or tingling in the mouth or throat
  • tightness in the chest
  • shortness of breath

• Severe gastrointestinal disorders. Symptoms may include:

  • diarrhea
  • pain or swelling in the abdomen
  • nausea or vomiting

• Low blood pressure.Symptoms may include:

  • dizziness
  • fainting
  • concentration problems

Weight loss / weight gain

You are unlikely to experience weight changes when using Amitiza. Weight gain has occurred in studies using Amitiza, but this has been rare.

In clinical studies, weight loss was not a side effect that people experienced while taking Amitiza. However, a small number of people did gain weight.Less than 1 percent of people with irritable bowel syndrome who take Amitiza to treat constipation have experienced weight gain.

Studies of people with chronic idiopathic constipation (CIC) or opioid-induced constipation (OIC) have not shown weight gain as a side effect.

Loss of appetite

Loss of appetite is also unlikely when you are taking Amitiza.

In clinical studies of people who received Amitiza twice a day, less than 1 percent had a decrease in appetite.

Nausea

Nausea is a common side effect of Amitiza. In clinical studies, 8 to 29 percent of people taking the drug experienced nausea. Prices depended on the type of constipation and the dosage of the drug. The incidence of nausea was lower in both men and the elderly.

If you feel nauseous while taking Amitiz, try eating or eating while taking the medication. Food can help relieve nausea. If you experience severe nausea while taking Amitiz, talk to your doctor.

diarrhea

Diarrhea is a common side effect of Amitiza.

In clinical studies, 7 to 12 percent of people taking Amitiza experienced diarrhea. And 2 percent of people taking the drug experienced severe diarrhea.

Electrolytes

Changes in electrolyte levels (minerals involved in basic body functions) are not a side effect associated with Amitiza.

In clinical studies, people taking Amitiza did not report any symptoms of electrolyte imbalance.In addition, blood tests showed no change in electrolyte levels.

Headache

The use of Amitiza has been associated with headaches.

In clinical studies, 11 percent of people taking Amitiza for chronic idiopathic constipation (CIC) experienced headaches. But only 2 percent of people taking Amitiza for opioid constipation reported headaches. No headaches have been reported in people using Amitiza for Irritable Bowel Syndrome with Constipation (IBS-C).

depression

Depression is not usually associated with the use of Amitiza.

In clinical trials, depression was observed in less than 1 percent of people with irritable bowel syndrome with constipation. And symptoms of depression have not been reported in clinical trials of people taking Amitiza for chronic idiopathic constipation (CIC) or for opioid-induced constipation (OIC).

Amitiza dosage

The dose of Amitiza your doctor prescribes will depend on several factors.This includes:

• The type and severity of the condition you are using Amitiza to treat
• other medical conditions you may have
• Your age

Typically, your doctor will prescribe a low dosage for you and adjust it over time to achieve the dosage that’s right for you. Ultimately, they will prescribe the lowest dosage that will produce the desired effect.

The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage prescribed by your doctor . Your doctor will determine the best dosage for your needs.

Dosage forms and strengths

Amitiza is available as a capsule that you take by mouth. It is available in two strengths: 8 mcg and 24 mcg. The maximum recommended dosage is 48 mcg per day.

Dosage for Chronic Idiopathic Constipation (CIC) and Opioid-Induced Constipation (OIC)

The typical dose recommended for adults is 24 mcg twice daily.Do not take more than directed by your doctor.

If you have liver damage, your doctor may prescribe a reduced dose of 16 mcg twice a day or 8 mcg twice a day.

Irritable Bowel Syndrome with Constipation (IBS-C) Dosage

The recommended adult dose is 8 mcg twice a day.

If you have severe liver damage, your doctor may prescribe 8 mcg once a day.

What if I miss a dose?

If you miss a dose, take it as soon as you remember.

But if it’s time to take your next dose, skip the missed dose and go back to your usual time. Do not take additional medicines to make up for a missed dose.

Cost of Amitiz

As with all medicines, Amitiza cost may vary. For current Amitiza prices in your area, check GoodRx.com:

The cost you find on GoodRx.com is what you can pay without insurance. The actual price you will pay will depend on your insurance coverage, your location, and the pharmacy you use.

Financial assistance

If you need financial support to pay for Amitiza, help is available.

Takeda Pharmaceuticals USA, Inc, the manufacturer of Amitiza, offers the Amitiza Loyalty Card. This card offers savings for eligible people with commercial insurance. For more information and to find out if you are eligible, visit the program website.

Takeda also offers a financial assistance program called Help at Hand.For information, visit the program website or call 800-830-9159.

Amitiza uses

The Food and Drug Administration (FDA) approves drugs such as Amitiza for specific purposes.

Permitted uses for Amitiza

Amitiza is approved for the treatment of three types of constipation.

Amitiza for chronic idiopathic constipation

Amitiza is approved for the treatment of chronic idiopathic constipation (CIC) in adults.”Idiopathic” means that the exact cause of constipation is unknown.

In clinical studies, Amitiza was found to provide rapid relief from CIC.

Approximately 57 to 63 percent of people taking Amitiza experienced bowel movements within the first 24 hours after taking the medication. Among those who took a placebo (no medication), 32 to 37 percent had a bowel movement. In addition, people taking Amitiza had less time to have their first bowel movement.

Amitiza for IBS-C

Amitiza is also approved for the treatment of irritable bowel syndrome with constipation (IBS-C). This condition is a form of irritable bowel syndrome (IBS) in which abdominal pain is associated with constipation.

In two different clinical studies, Amitiza improved common IBS-C symptoms such as abdominal pain and discomfort.

About 14 percent of people in one study responded to Amitiza, while only 8 percent responded to a placebo (no medication).This means that they had a significant improvement in their symptoms and did not need to take laxatives or other medications to treat constipation. In another study, 12 percent of people taking Amitiza responded, compared with 6 percent in the placebo group.

Amitiz for OIC

Amitiza is also approved for the treatment of opioid constipation (OIC). This type of constipation occurs when people take opioids, which are prescribed to treat pain. Amitiza is only approved for people who are taking opioids for long-term pain that is not cancer-related.

Three 12-week clinical studies looked at the use of Amitiza in people with OIC. Of these people, 13 to 27 percent had increased bowel movements while taking Amitiz. About 13–19 percent of people who took a placebo (no medication) had the same result.

Uses that are not approved for Amitiza

You may wonder if Amitiza can be used to treat other conditions. Constipation is the only condition that is approved for treatment.

Amitiza for gastroparesis

Amitisa is not approved for the treatment of gastroparesis. In this condition, your stomach cannot move food to the small intestine.

Like constipation, gastroparesis slows down or stops normal digestion. And constipation can be a symptom of gastroparesis. However, Amitiza has not been studied in people with gastroparesis. This means that we do not know if the drug can relieve gastroparesis.

If you have gastroparesis, talk to your doctor about treatment options that may help relieve the situation.

Amitiza for children

Amitiza is not approved for use in children. This is because it has not been found to be safe or effective for treating constipation in children.

In a clinical study of children aged 6 to 17 years, Amitiza was not found to be effective in the treatment of constipation.

If your child is showing signs of constipation, talk with your doctor about medications or other treatments that might help relieve it.

Is Amitya a laxative?

Amitiza is not classified as a fiber or traditional laxative. However, it produces the same effects as other treatments. This increases the level of fluid in the intestines, which helps the stool pass.

Amitiza is a medicine called a chloride channel activator. Chloride channels are found in most of the cells in your body. These are proteins that transport specific molecules across cell membranes.

In the gastrointestinal tract, these channels play an important role in the transport of fluid.Amitisa activates these channels, which increases the amount of fluid in the intestines. The increased fluid helps your body pass stools.

Alternatives to Amitise

Other drugs are available that can treat various types of constipation. Some may be better for you than others. If you are looking for an alternative to Amityse, talk with your doctor to find out more about other medicines that may help you.

Note: Some of the drugs listed here are used off-label to treat constipation.

Alternatives to opioid-induced constipation (OIC)

Other drugs that can be used to treat OIC are divided into five main groups.

Chair softeners

These drugs allow water and fat to enter the stool, making it easier for them to pass. Examples of chair softeners include:

docusate (Colace, Col-Rite, Doc-Q-Lace, Docusoft-S, Phillips Liqui-Gels, Silace, Surfak, others)

Stimulant laxatives

These drugs help to stimulate contraction (contraction) and relaxation of the intestinal muscles.This action helps move the stool through the intestines.

Examples of stimulant laxatives include:

• Bisacodyl (Ducodyl, Dulcolax, Fleet Bisacodyl, GoodSense Bisacodyl EC)
• senna (ex-Lax, Jeri-cat, GoodSense, Laxative tablets, Senecot, SennaCon, Senna Lax)

Osmotic laxatives

These drugs work by drawing more water into the intestines. This helps to soften the stool and make it easier to pass.

Examples of osmotic laxatives include:

• polyethylene glycol (GlycoLax, MiraLAX)
• lactulose (Constulose, Enulose, Generlac, Kristalose)
• sorbitol
• magnesium sulfate
• magnesium citrate
• glycerin

lubricants

These drugs work by keeping water in the intestines and stools. This makes the chair softer so that it is easier to walk through.

Examples of lubricants include:

Mineral oil (Fleet Oil, GoodSense Mineral Oil)

Peripherally acting mu-opioid receptor agonists (PAMORAs)

Opioids slow down the gastrointestinal tract and reduce the amount of fluid in the intestines.These effects can cause constipation. PAMORA works by blocking the action of opioids in certain parts of the body, including the gastrointestinal tract. It reduces constipation caused by opioid use without affecting pain relief.

Examples of PAMORA include:

• methylnaltrexone (relay)
• naloxegol (movable)
• Naldemidine (Simproic)

Alternatives for Chronic Idiopathic Constipation (CIC)

Other drugs that can be used to treat CEC belong to four main groups.

Selective agonists of serotonin-4 (5-HT4) receptors

Typically, your intestines move food through them by squeezing (squeezing) and relaxing the muscles in the intestinal walls. When this activity slows down, constipation can occur.

Selective serotonin-4 (5-HT4) receptor agonists work by stimulating this action in your gut. An example of this remedy:

prucaloprid (Motegrity)

Agonists guanylate cyclase-C

These medicines work by increasing the amount of water in the intestines.This softens the stool, which helps it move through the intestines. These drugs work similarly to Amitise, but work on a different type of protein.

Examples of guanylate cyclase-C agonists include:

• Trulance
• Linaclotide (Linzess)

Osmotic laxatives

These drugs work by drawing more water into the intestines. This helps to soften the stool and make it easier to pass.

Examples of osmotic agents include:

• polyethylene glycol (GlycoLax, MiraLAX)
• lactulose (Constulose, Enulose, Generlac, Kristalose)

Stimulant laxatives

Similar to selective serotonin-4 (5-HT4) receptor agonists (ref.Above), stimulant laxatives work by stimulating the muscles in the intestines. Laxatives cause the muscles to contract and relax, which moves the stool through the intestines.

Examples of stimulant laxatives include:

• Bisacodyl (Ducodyl, Dulcolax, Fleet Bisacodyl, GoodSense Bisacodyl EC)
• sodium picosulfate
• senna (ex-Lax, Jeri-cat, GoodSense, Laxative tablets, Senecot, SennaCon, Senna Lax)

Alternatives for Irritable Bowel Syndrome with Constipation (IBS-C)

Other drugs that can be used to treat IBS-C are divided into five main groups.

Fillers

These drugs work by absorbing water in your intestines and then swelling. This increases the amount of stool you have, which stimulates bowel movement. Examples of fillers include:

• Psyllium (Metamucil, Laxmar, Genfiber, Fiberall)
• methylcellulose (Citrucel, GoodSense Fiber)
• calcium polycarbophil (FiberCon)

Chair softeners

These drugs allow water and fat to enter the stool, making it easier for them to pass.Examples of surfactants include:

docusate (Colace, Col-Rite, Doc-Q-Lace, Docusoft-S, Phillips Liqui-Gels, Silace)

Osmotic laxatives

These drugs work by increasing the amount of water in the intestines. This helps to soften the stool and make it easier to pass. Examples of osmotic agents include:

• Magnesia Milk (Pedia-Lax, Phillips)
• magnesium citrate
• magnesium sulfate
• Sodium Picosulfate / Magnesium Citrate (PicoPrep)
• lactulose / lactitol
• sorbitol

Stimulant laxatives

Stimulant laxatives work by stimulating the muscles in the intestines.Laxatives cause the muscles to contract and relax, which moves the stool through the intestines.

Examples of stimulant laxatives include:

• Bisacodyl (Ducodyl, Dulcolax, Fleet Bisacodyl, GoodSense Bisacodyl EC)
• sodium picosulfate
• senna (ex-Lax, Jeri-cat, GoodSense, Laxative tablets, Senecot, SennaCon, Senna Lax)

Guanylate cyclase-C agonists

These medicines work by increasing the amount of water in the intestines.This softens the stool, which helps it move through the intestines. These drugs work similarly to Amitise, but work on a different type of protein.

Examples of guanylate cyclase-C agonists include:

• Trulance
• Linaclotide (Linzess)

Amitiza versus other drugs

You may ask how Amitiza compares to other medicines prescribed for similar purposes. Below are comparisons of Amitiza and several medicines.

Amitiza vs. Linzess

Amitiza contains lubiprostone, which is a chloride channel activator. Chloride channels are proteins that transport specific molecules across cell membranes. By activating chloride channels in your intestines, Amitisa increases the amount of fluid that goes into your intestines. This will help you pass the stool more easily.

Linzess contains linaclotide, which is a guanylate cyclase-C (GC-C) agonist. Although this is a different type of drug and does not work in the same way as Amitisa, Linness also increases the amount of water in the intestines.This softens the stool and makes it easier to pass.

Benefits

Both Amitiza and Linzess are approved for the treatment of chronic idiopathic constipation (CIC). They are also approved for the treatment of irritable bowel syndrome with constipation (IBS-C), but Amitiza is only approved for use by women aged 18 years or older. Amitiza is also approved for the treatment of opioid constipation in adults.

Dosage Forms and Administration

Amitiza and Linzess both come in as oral capsules. Linzess is taken once a day, while Amitiza is usually taken twice a day.

Side effects and risks

Amitiza and Linzess can cause similar common and serious side effects.

More common side effects

These lists provide examples of more common side effects that can occur with Amitiz, Linzess, or both (when taken individually).

• Can happen to Amitiza:
  • Headache
  • nausea
  • dizziness
• Can happen to Linzess:
  

  no unique common side effects

• Can happen to both Amitiza and Linzess:
  • diarrhea
  • gas
  • pain or pressure in the abdomen

Serious side effects

These lists provide examples of serious side effects that can occur with Amitiz, Linzess, or both (when taken individually).

• Can happen to Amitiza:
  • low blood pressure
  • fainting
• Can happen to Linzess:
  • blood in your stool (stool looks like tar)
  • severe abdominal pain
  • severe dehydration in children under 6 years of age *
• Can happen to both Amitiza and Linzess:
  • severe diarrhea
  • serious allergic reaction

* Linzess has a boxed warning from the FDA.A boxed warning is the strongest warning that the FDA requires. The warning states that Linzess should not be used in children under 6 years of age due to the risk of severe dehydration. The use of Linzess in children between the ages of 6 and 18 should also be avoided because the safety and efficacy of the drug in these children has not been studied.

efficiency

Amitisa and Linzess have not been directly compared in clinical trials. However, they have been studied separately.

Studies have shown that Amitiza and Linzess are effective in the treatment of IBS-C and CIC.

Expenses

Amitiza and Linzess are both branded drugs. There is currently no generic drug available. Brand name drugs tend to cost more than generics.

GoodRx.com estimates that Amitiza typically costs less than Linzess. The actual price you pay for each drug depends on your insurance plan, your location, and the pharmacy you use.

Amitiza vs. Movantik

Amitiza contains the drug lubiprostone, while Movantik contains the drug naloxegol. These drugs are used for similar reasons, but they work differently in the body.

Benefits

Both Amitiza and Movantik are approved for the treatment of opioid constipation in adults with chronic non-cancer pain. Amitiza is also approved for the treatment of adults with constipated irritable bowel syndrome and adults with chronic idiopathic constipation.

Dosage Forms and Administration

Amitiza is available in the form of oral capsules. It is usually taken twice a day. Movantik is available in the form of oral tablets. It is taken orally once a day.

Side effects and risks

Amitiza and Movantik can cause similar common and severe side effects.

More common side effects

These lists provide examples of the more common side effects that can occur with Amitiz, Movantik, or both (when taken individually).

• Can happen to Amitiza:
  

  dizziness

• Can happen to Movantik:
  

  increased sweating

• Can happen to both Amitiza and Movantik:
  • abdominal pain
  • diarrhea
  • nausea
  • gas
  • vomiting
  • Headache

Serious side effects

These lists provide examples of serious side effects that can occur with Amitiz, Movantik, or both (when taken individually).

• Can happen to Amitiza:
  • low blood pressure
  • fainting
• Can happen to Movantik:
  

  severe abdominal pain

• Can happen to both Amitiza and Movantik:
  • severe diarrhea
  • serious allergic reaction

efficiency

Amitiza and Movantik have different FDA-approved uses, but both are used to treat opioid-induced constipation (OIC) in adults.

The effectiveness of these drugs has not been directly compared in clinical trials. However, separate studies of Amitiza and Movantik have shown that both are effective for the treatment of OIK.

Expenses

Amitiza and Movantik are both branded drugs. There is currently no generic drug available. Brand name drugs tend to cost more than generics.

GoodRx.com estimates that Amitiza is generally cheaper than Movantik. The actual price you pay for each drug depends on your insurance plan, your location, and the pharmacy you use.

Amitiza Instructions

You must take Amitiza as directed by your doctor or healthcare provider.

How to take

Swallow a whole Amitiz capsule. Do not chew or break the capsule into pieces.

When to get

Amitiza is usually taken once in the morning and once in the evening or once a day. Your doctor will tell you how often you should take it and when.

Taking Amitiza with food

Take Amitiza with food and full glass of water.Taking Amitiza with a small meal can help reduce the risk of nausea, which can be a common side effect.

Can Amitiza be crushed?

Amitiza capsules must not be crushed, broken or chewed. Be sure to swallow the capsule whole.

Amitiza and alcohol

There are no known interactions between alcohol and Amitiza. However, you may feel dizzy or lightheaded while taking Amitiza. Drinking alcohol can also cause these effects, so when they get worse together, these effects can worsen.

If you get dizzy while taking Amitiz, it is best to avoid alcohol. If you have trouble quitting alcohol and it makes you feel dizzy or dizzy, talk to your doctor.

Amitiza Interaction

Most medicines can interact with other medicines. Different interactions can have different effects. For example, some of them can interfere with the effectiveness of a medicine, while others can cause increased side effects.

Amitiza and other medicines

Before taking Amitiza, be sure to tell your doctor and pharmacist about all prescription, over-the-counter, and other medicines you are taking. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.

If you have any questions about drug interactions that may affect you, ask your doctor or pharmacist.

The following are examples of medications that can interact with Amitiza. This list does not contain all medicines that can interact with Amitiza.

Amitiz and high blood pressure drugs

Taking Amitiza with medicines to treat high blood pressure may increase the risk of fainting or low blood pressure. If you are taking medicines to lower your blood pressure, tell your doctor before you start taking Amitiza.

Amitiza and antidiarrheals

Taking Amitiza with drugs used to treat diarrhea may make Amitiza less effective. If you experience diarrhea while taking Amitiza, do not try to treat the diarrhea yourself. Instead, talk to your doctor. They may decide that you need a lower dose of Amitiz or that you should stop taking the drug.

Examples of antidiarrheal drugs include:

• Alosetron (Lotronex)
• loperamide (imodium)
• bismuth subsalicylate (Pepto-Bismol)

Amitiza and Miralax

If Amitiza does not provide enough relief from your constipation, you can take it with MiraLAX.There is no known interaction between Amitiza and MiraLAX. It is generally safe to take them together.

This combination has a small risk of side effects. A clinical study looked at the off-label use of Amitiza with MiraLAX as a bowel cleansing agent prior to colonoscopy. In research:

• About 4 percent of people have had abdominal cramps
• Less than 2 percent of people had nausea

90,540 less than 1% of people had bloating 90,541

Before using these drugs together, tell your doctor or pharmacist that you would like to add MiraLAX to your treatment plan.

Amitiza and Methadone

In laboratory tests, methadone (an opioid pain reliever) has been shown to reduce the effects of chloride channels. Chloride channels are proteins that transport specific molecules across cell membranes.

This effect may prevent Amitise from performing well. This is because Amitisa works by activating the same chloride channels that help increase fluid levels in the intestines. The increased fluid helps pass through the intestines.

Tell your doctor if you are taking methadone. Your doctor may choose another medicine instead of Amitiza to help treat your constipation.

How Amitiza Works

Amitiza belongs to a class of drugs called chloride channel activators. Chloride channels are found throughout the body in virtually every cell type. These are proteins that transport specific molecules across cell membranes.

Amitisa activates (increases activity) these chloride channels in your intestines.This action increases the amount of fluid that gets into your intestines. This increase in fluid allows stool to pass through your system more easily, helping to relieve constipation.

How long does the job take?

Amitiza starts working quickly. For example, a clinical study focused on the use of Amitiz in adults with chronic idiopathic constipation (CIC). About 57 percent of the people studied had a bowel movement within 24 hours of taking the medication. In the placebo group (no medication), this effect was found in only 37 percent of people.

Within 48 hours of treatment, 80 percent of people taking Amitiza experienced a bowel movement. Only 61 percent of people in the placebo group had the same result.

Amitiza and pregnancy

Not enough research has been done to find out if Amitiza is safe to use during pregnancy. In animal studies, Amitiza has been shown to harm the fetus. However, animal studies do not always predict what will happen to humans.

If you are pregnant or become pregnant while being treated with Amitisa, talk to your doctor. Together, you can assess the benefits and risks of using Amitiz during pregnancy.

Amitisa and breastfeeding

It is not known whether Amitiza passes into breast milk, or how it might affect milk production in your body. In animal studies, Amitisa was not found in the milk of lactating animals. But animal studies don’t always reflect the effects that humans might have.

Talk to your doctor about whether using Amitiz is a good idea for you while you are breastfeeding. And if you choose to breastfeed your baby while taking Amitiza, watch for signs of diarrhea. Amitisa can cause diarrhea in a breastfed baby. If your baby develops diarrhea, stop breastfeeding and see a doctor.

General questions about Amitiz

Here are answers to some frequently asked questions about Amitiz.

Can Amitiza be used for men?

Amitiza is approved for the treatment of three types of constipation in adults. For two of these types, it can be used in males. These types are chronic idiopathic constipation (CIC) and constipation caused by opioid treatment in people with chronic pain that is not caused by active cancer.

However, the third type of constipation that Amitiza is approved for treatment cannot be used in men. This type of Irritable Bowel Syndrome with Constipation (IBS-C).

The reason for this difference is that there have not been enough studies on the use of Amitiz in men with IBS-C. In clinical studies, only 8 percent of people with IBS-C that were studied were men. Because the male population in the studies was so low, we do not have sufficient data to determine if men with IBS respond to Amitiza differently than women.

Will I have withdrawal symptoms when I stop taking Amitiza?

No, you most likely will not have withdrawal symptoms when you stop Amitiza.In a clinical study in which people stopped treatment with the drug, no such symptoms were observed.

Is Amitiza a Controlled Substance?

No, Amitiza is not a controlled substance. A controlled substance is a drug that is regulated by the government because of its potential for abuse.

However, Amitiza is a medicine that requires a prescription from your doctor.

Amitiz Alert

Before taking Amitiza, talk with your doctor about your medical history.Amitiza may not be right for you if you have certain medical conditions. This includes:

• Bowel block . If you have a bowel obstruction, you should not use Amitiza. If you are not sure if you have one, ask your doctor to examine you before starting treatment with Amitiza.
• Severe diarrhea . Taking Amitiza can make severe diarrhea worse. If you have severe diarrhea, you should avoid taking this drug.
• History of allergy to Amitiza or any of its ingredients .If you are allergic to Amitiza or have had a reaction in the past, you should not use Amitiza. If you have such allergies, talk to your doctor about other treatment options for constipation.

Overdose of Amitiz

Taking too much Amitiza may increase your risk of serious side effects.

Overdose symptoms

Overdose symptoms may include:

• nausea
• diarrhea
• vomiting
• dizziness
• Headache
• abdominal pain
• flushing (warmth and redness on the face or neck)
• dry bundles (vomiting)
• shortness of breath
• tightness in the chest
• fainting

What to do in case of overdose

If you think you have taken too much of this medicine, call your doctor or seek advice from the American Association of Poison Control Centers at 800-222-1222 or through their online tool. But if your symptoms are severe, call 911 or go to the nearest emergency room right away.

Amitiz Expiry

When Amitiza is dispensed from the pharmacy, the pharmacist will add the expiration date to the bottle label. This date is usually one year from the date the medication was dispensed.

The purpose of these expiration dates is to ensure that the drug is effective during this time. The current position of the Food and Drug Administration (FDA) is to avoid using expired drugs.

How long a medicine stays good depends on many factors, including how and where the medicine is stored. Amitiza capsules should be stored at room temperature around 77 ° F (25 ° C). Store them in a dry place in a tightly closed and lightfast container. Do not store medicines in your bathroom.

If you have an unused medicine that has expired, talk to your pharmacist about whether you can still use it.

Professional Information for Amitiza

The following information is provided for physicians and other healthcare professionals.

Mechanism of action

Amitisa is a chloride channel activator (CIC) that increases the secretion of intestinal fluid, which helps to improve fecal transit. The CIC-2 receptor is activated by Amitisa. Increasing the fluid that contains chloride helps increase mobility and allows stool to pass through the intestines.

The antisecretory effects of opiates are ignored and serum sodium and potassium concentrations remain unchanged. It is also seen that amitisa triggers the restoration of the barrier function of the mucous membrane and reduces intestinal permeability by restoring tight joints.

Pharmacokinetics and metabolism

Plasma concentrations of Amitis are below precise counting levels. Consequently, the half-life and maximum concentrations cannot be reliably calculated. However, the pharmacokinetics of M3 was calculated, which is the only active metabolite of Amitis that can be measured.

After oral administration, the maximum concentration of M3 occurs within one hour. The administration of a high fat diet may decrease the maximum concentration.However, Amitisa was taken with food and water in most clinical trials.

The half-life of M3, which is the only active metabolite of Amitiza that can be measured, was approximately 1 to 1.5 hours.

Amitiza is believed to be rapidly metabolized in the stomach and jejunum.

Contraindications

Amitiza is contraindicated in people who have had an allergic reaction in the past, as well as people who have had a blockage in the stomach or intestines.

Storage

Amitiza

should be stored at room temperature around 77 ° F (25 ° C).

Disclaimer: Healthline has made every effort to ensure that all information is in fact correct, complete and current. However, this article should not be used as a substitute for the knowledge and experience of a licensed healthcare professional. You should always consult with your doctor or other healthcare professional before taking any medication.The drug information contained in this document is subject to change and is not intended to cover all possible uses, indications, precautions, warnings, drug interactions, allergic reactions or side effects. The absence of warnings or other information about a particular drug does not mean that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

90,000 CONSTITUTION TREATMENT: MEDICINES, NATURAL REMEDIES AND MUCH MORE – DIGESTIVE

If you are one of the millions of Americans with chronic constipation, you know how frustrating it can be when you don’t have a regular bowel movement.With symptoms like bloating and cramps, constipation is no joke despite many jokes about it.

Constipation is sometimes uncomfortable to talk about. Many people living with this condition simply agree that their bowel movements will always be a problem instead of seeking treatment.

You don’t have to live in pain. There are a number of remedies that can help you manage your symptoms and dramatically improve your quality of life.

Let’s take a look at some of the most popular treatment options.

Over-the-counter laxatives

When looking for remedies for chronic constipation, it is best to start at your local pharmacy. There is a wide range of over-the-counter drugs available in various forms such as powders, tablets, and suppositories.

Here are some facts about the most common types of over-the-counter laxatives:

Fiber supplements

Fiber supplements increase volume and soften stools.They can last for several days and are safe for long term use. They should be taken with plenty of liquid. Side effects can include stomach pain and bloating.

Common varieties:

• psyllium (metamucil)
• methylcellulose (Citrucel)
• calcium polycarbophil (FiberCon)

Available forms:

• powder
• tablets
• tablets
• tablets

Osmotics

Osmotics increase the amount of water in the intestine and help move fluid through the colon.They are fast acting and safe for long term use. They should be taken with plenty of liquid. They can cause stomach pain and diarrhea.

Common varieties:

• magnesium citrate (Citroma)
• magnesium hydroxide (milk of magnesia)
• polyethylene glycol (MiraLAX)

Available forms:

• powders
• tablets
• tablets
• tablets
• tablets

Stool softeners

Stool softeners draw water out of the intestines to soften the stool and make it easier to pass.They can last for several days and are safe for long term use. One of the advantages of stool softeners over other OTC laxatives is that they generally do not cause any side effects.

Common varieties:

• sodium docusate (Colace)
• calcium docusate (sulfolax)

Available forms:

• tablets
• tablets
• liquids
• 9055 suppositories
• suppositories

• Lubricants

  Lubricants coat and lubricate stools to facilitate passage through the intestines.They usually work six to eight hours. They should not be used long-term as they can be addictive. Side effects include stomach pain and cramping.

  Common varieties:

  • Fleet Mineral Oil Enema

  Available Forms:

  • Liquids
  • Enemas

  Stimulants

  Stimulants make the intestines contract faster and harder. They will take effect in 6-10 hours.They should not be used for long periods of time as they can increase your body’s tolerance to similar medicines. Side effects include stomach pain and cramping.

  Common varieties:

  • bisacodyl (Dulcolax)
  • sennoside (Haymouth)

  Available forms:

  • tablets
  • liquids
  • suppositories
  • enemas

  Probiotics

  Probiotics introduce cultures of beneficial bacteria into your body to aid digestion.They can start working within an hour, but it can take several days. They are safe for long term use. Side effects include stomach pain and bloating.

  Common varieties:

  • Bifidobacteria
  • Lactobacilli

  Available forms:

  • fermented foods (yoghurt, some pickled vegetables, some cheeses)

  Prescription drugs

  If over-the-counter laxatives don’t work, you can talk to your doctor about taking a prescription drug.While they may not work as quickly as over-the-counter drugs, they can help increase your overall bowel movement in the long term.

  Here are some facts about the most common types of prescription drugs for chronic constipation:

  Linaclotide

  Linaclotide accelerates the movement of stool through the intestines and regulates the amount of intestinal fluid. It usually starts working during the day. Not recommended for children. Side effects include stomach pain, bloating, gas, and diarrhea.

  Brand name: Linzess

  Available form: tablet

  Plecanatide

  Plecanatide speeds up stool movement and regulates the amount of intestinal fluid. It usually starts working during the day and is safe for long term use. Not recommended for children. Side effects include stomach pain, bloating, gas, and diarrhea.

  Brand: Trulance

  Available Form: Tablet

  Methylnaltrexone

  Methylnaltrexone prevents the binding of opioids to receptors in the intestine.Recommended for people who have constipation caused by prescription opioid use. It usually starts working during the day and is safe for long term use. Side effects include stomach pain, nausea, and diarrhea.

  Brand Name: Relistor

  Available Forms: Tablet or Injection.

  Naloxegol

  Naloxegol also prevents the binding of opioids to receptors in the intestine. Like methylnaltrexone, it is recommended for people who have constipation from prescription opioids.It usually starts working during the day and is safe for long term use. Side effects include stomach pain, nausea, and diarrhea.

  Brand name: Movantik

  Available form: tablet

  Chloride channel activators

  Chloride channel activators increase the amount of water in the intestine and help move fluid through the colon. They usually start working during the day and are safe for long term use. Side effects include stomach pain, nausea, and diarrhea.

  Common variety: Lyubiproston (Amitiza).

  Available form: tablet

  Lifestyle Changes

  In addition to the over-the-counter and prescription drugs described above, you can make lifestyle changes that can help you manage chronic constipation.

  Increase your fluid intake

  Drinking plenty of fluids can soften stools and prevent dehydration, which sometimes causes poor bowel movements.The recommended fluid intake for adults is 11.5 cups per day for women and 15.5 cups per day for men.

  Coffee also increases bowel activity in some people, but due to the potential for bladder irritation, you should not rely on caffeinated beverages as your main source of fluids.

  Diet

  Eating a healthy, balanced diet can also help your bowels become more regular. Whenever possible, choose foods that are high in fiber and low in fat, such as whole grains, fruits and vegetables, unsalted seeds, and nuts.

  As a general rule, try to include 14 grams of fiber in your diet for every 1000 calories you eat. Also, try to eat at least five servings of fruits and vegetables a day.

  Exercise

  Staying active is another way to help manage chronic constipation. Exercise increases the muscle activity in the intestines, which gives them more strength to pass feces into the intestines and colon.

  Even mild exercise, such as walking and climbing stairs, can be effective for bowel movement.If possible, try to exercise for at least 30 minutes most days of the week.

  Develop a daily routine

  It may be helpful to schedule a specific time each day to try to have a bowel movement. About half an hour after breakfast is a good time, especially if you have coffee in the morning.

  You may also consider placing your feet on something while sitting on the toilet with your knees higher than your hips, as this position can make it easier for the stool to pass through the colon.