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Suppositories how long to work: How do suppositories work? Uses, instructions, and pictures

How do suppositories work? Uses, instructions, and pictures

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Our team thoroughly researches and evaluates the recommendations we make on our site. To establish that the product manufacturers addressed safety and efficacy standards, we:

  • Evaluate ingredients and composition: Do they have the potential to cause harm?
  • Fact-check all health claims: Do they align with the current body of scientific evidence?
  • Assess the brand: Does it operate with integrity and adhere to industry best practices?

We do the research so you can find trusted products for your health and wellness.

Read more about our vetting process.

Was this helpful?

Suppositories are solid medications that enter the body through the rectum, vagina, or urethra. Rectal suppositories are the most common type of suppository.

Doctors recommend the different forms of suppositories for different medical conditions and purposes. People place some in the rectum and others in the vagina. Less commonly, a person will need to use urethral suppositories.

We give step-by-step guidance on how to use suppositories in this article.

We also provide some helpful troubleshooting tips and advice for people who need to use this type of medication.

Share on PinterestPeople use suppositories when they are unable to take drugs orally.

Suppositories are another way to deliver drugs to the body when other routes, such as oral, cannot be used.

A suppository is small and may be round, oval, or cone-shaped. A substance, such as cocoa butter or gelatin, surrounds the medication. The suppository dissolves to release the drug once inside the body.

Suppositories may treat the local area, or the medicine may travel to other parts of the body through the bloodstream.

Why use suppositories?

Suppositories deliver many types of medication, and a person may need to use them if they:

  • are having seizures and cannot take medicines by mouth
  • are unable to swallow medication for any reason
  • are vomiting and cannot keep pills or liquids down
  • have a blockage that stops the medication moving through the digestive system

People may also take suppositories if the medication:

  • tastes too bad to take by mouth
  • would break down too quickly in the gut
  • could be destroyed in the gastrointestinal tract

Research also suggests that taking medications through the rectum allows for a relatively constant environment for a drug to be delivered. The rate of absorption may, however, be lower than that of drugs taken by mouth.

There are three types of suppositories:

Rectal suppositories

Rectal suppositories go in the rectum or anus. They are typically an inch long and have a rounded tip.

They treat conditions, such as:

  • constipation
  • fever
  • hemorrhoids
  • mental health issues such as anxiety, schizophrenia, or bipolar disorder
  • nausea, including motion sickness
  • pain

Vaginal suppositories

People may insert vaginal suppositories into the vagina to treat:

  • bacterial or fungal infections
  • vaginal dryness

Vaginal suppositories are typically oval and come with an applicator.

Urethral suppositories

Men may use a type of urethral suppository to treat erection problems in rare cases.

These suppositories are the size of a grain of rice and deliver a drug called alprostadil.

Anyone using a rectal suppository may want to refer to the following steps for guidance:

1. Get prepared

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  • Try to pass stool to empty the colon, as suppository medication is most effective when the bowel is empty.
  • Wash hands thoroughly with soap and warm water or use a hand sanitizer. Dry the hands thoroughly on a clean towel or paper towel.
  • Carefully remove the suppository from its wrapper.
  • If it is necessary to cut the suppository, use a clean, single-edge razor blade to slice it lengthwise.
  • Use a disposable glove, if desired.

2. Get ready to insert the suppository

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  • Dip the tip of the suppository in water, or apply a small amount of water-based lubricant, such as K-Y Jelly that is available to buy online. A lubricant helps the suppository more easily slide into the rectum.
  • Remove clothing from the lower half of the body.
  • Find the correct position. Either stand up with one foot on a chair or lie down on one side with the top leg bent slightly toward the stomach. Caregivers giving the suppository to another person often find it easier if the person is lying down.

3. Insert the suppository

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  • Relax the muscles of the buttocks and open the cheeks.
  • Gently insert the suppository into the anus, narrow end first.
  • Push it in about 1 inch for adults, or half an inch for infants.
  • In older children, push the suppository in approximately half to one inch, depending on their size.

4. Relax and clean up

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  • Sit or lie still for 10 minutes after inserting the suppository. Staying still allows time for the suppository to dissolve in the body. Parents may need to hold a child’s buttocks closed during this time.
  • Dispose of all materials, including the suppository wrapper and any tissue paper.
  • Wash the hands thoroughly with soap and warm water.

Try to avoid passing stool for up to 60 minutes after inserting the suppository, unless it is a laxative. Not passing stool gives the medication enough time to enter the bloodstream and start working.

Share on Pinterest

To place a suppository into the vagina, follow these tips:

1. Get prepared

  • Wash hands with soap and warm water, or use a hand sanitizer if these are not available. Dry the hands well on a clean towel or paper towel.
  • Unwrap the suppository, and place it in the accompanying applicator.
  • Either stand with the knees bent and feet apart or lie down with the knees bent toward the chest.

2. Insert the suppository

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  • Place the applicator into the vagina, as far as possible, without causing discomfort.
  • Press down on the plunger to push in the suppository.
  • Remove the applicator from the vagina, and dispose of it.

3. Relax and clean up

  • Lie down for 10 minutes to allow the medicine to enter the body.
  • Wash the hands once more with soap and warm water.

Consider using a sanitary towel for a few hours, as some of the suppository may leak out onto the underwear.

To place a suppository into the urethra try the following tips:

1. Get prepared

  • Empty the bladder.
  • Wash the hands with soap and warm water or use a hand sanitizer. Dry the hands thoroughly on a clean towel or paper towel.
  • Remove the applicator cover.

2. Insert the suppository

  • Stretch out the penis to open the urethra.
  • Place the applicator into the hole at the tip.
  • Push the button on the applicator and hold for 5 seconds.
  • Gently move the applicator from side to side to ensure the suppository has entered the urethra.
  • Remove the applicator.

3. Relax and clean up

  • Massage the stretched penis firmly for 10 to 15 seconds to allow the medicine to be absorbed.
  • Dispose of the applicator and any other materials.
  • Wash the hands once more with soap and warm water.

Suppositories are usually safe to use. Sometimes, some of the medication may leak out. To avoid a mess, people may want to wear a sanitary towel or incontinence pad.

Some people may experience irritation around the area where they inserted the suppository. If this is severe or persists, they should see a doctor.

Occasionally, the body may not absorb the medication delivered by a suppository as well as it does oral medications.

The following tips may help people who need to use suppositories:

  • Avoid exercise or vigorous movement for 60 minutes after inserting the medication.
  • Do not use petroleum jelly, such as Vaseline, to lubricate the suppository. This stops it from melting. Only use water, or a water-based lubricant.
  • Store suppositories in the refrigerator or another cool place, so they do not melt. Always follow the storage directions on the label.
  • A soft suppository can be difficult to insert. Gently squeeze it to see if it is firm enough. If not, harden the wrapped suppository by holding it under a flow of cold water. Or, place it in the refrigerator for a few minutes.
  • Trim fingernails before inserting suppositories. This prevents cuts and scrapes. Alternatively, wear a latex glove.
  • Some people may notice the suppository falls out. This can occur because they have not pushed it far enough into the rectum. Push the medication in about 1 inch.
  • Those who struggle to use suppositories should consider asking a partner or caregiver for help.
  • As with other medicines, avoid missing doses. Missed doses may reduce the effectiveness of the treatment.

Suppositories are helpful for people who cannot take medications by mouth.

People who have difficulty using suppositories should ask their doctor for advice. They should also talk to their doctor before using suppositories if they:

  • have had recent rectal surgery, prostate surgery, or vaginal treatment
  • have an irregular heartbeat

Although they may be unpleasant to use, rectal, vaginal, and urethral suppositories can be an effective way of delivering medication.

How do suppositories work? Uses, instructions, and pictures

We include products we think are useful for our readers. If you buy through links on this page, we may earn a small commission Here’s our process.

Medical News Today only shows you brands and products that we stand behind.

Our team thoroughly researches and evaluates the recommendations we make on our site. To establish that the product manufacturers addressed safety and efficacy standards, we:

  • Evaluate ingredients and composition: Do they have the potential to cause harm?
  • Fact-check all health claims: Do they align with the current body of scientific evidence?
  • Assess the brand: Does it operate with integrity and adhere to industry best practices?

We do the research so you can find trusted products for your health and wellness.

Read more about our vetting process.

Was this helpful?

Suppositories are solid medications that enter the body through the rectum, vagina, or urethra. Rectal suppositories are the most common type of suppository.

Doctors recommend the different forms of suppositories for different medical conditions and purposes. People place some in the rectum and others in the vagina. Less commonly, a person will need to use urethral suppositories.

We give step-by-step guidance on how to use suppositories in this article.

We also provide some helpful troubleshooting tips and advice for people who need to use this type of medication.

Share on PinterestPeople use suppositories when they are unable to take drugs orally.

Suppositories are another way to deliver drugs to the body when other routes, such as oral, cannot be used.

A suppository is small and may be round, oval, or cone-shaped. A substance, such as cocoa butter or gelatin, surrounds the medication. The suppository dissolves to release the drug once inside the body.

Suppositories may treat the local area, or the medicine may travel to other parts of the body through the bloodstream.

Why use suppositories?

Suppositories deliver many types of medication, and a person may need to use them if they:

  • are having seizures and cannot take medicines by mouth
  • are unable to swallow medication for any reason
  • are vomiting and cannot keep pills or liquids down
  • have a blockage that stops the medication moving through the digestive system

People may also take suppositories if the medication:

  • tastes too bad to take by mouth
  • would break down too quickly in the gut
  • could be destroyed in the gastrointestinal tract

Research also suggests that taking medications through the rectum allows for a relatively constant environment for a drug to be delivered. The rate of absorption may, however, be lower than that of drugs taken by mouth.

There are three types of suppositories:

Rectal suppositories

Rectal suppositories go in the rectum or anus. They are typically an inch long and have a rounded tip.

They treat conditions, such as:

  • constipation
  • fever
  • hemorrhoids
  • mental health issues such as anxiety, schizophrenia, or bipolar disorder
  • nausea, including motion sickness
  • pain

Vaginal suppositories

People may insert vaginal suppositories into the vagina to treat:

  • bacterial or fungal infections
  • vaginal dryness

Vaginal suppositories are typically oval and come with an applicator.

Urethral suppositories

Men may use a type of urethral suppository to treat erection problems in rare cases.

These suppositories are the size of a grain of rice and deliver a drug called alprostadil.

Anyone using a rectal suppository may want to refer to the following steps for guidance:

1.

Get prepared

Share on Pinterest

  • Try to pass stool to empty the colon, as suppository medication is most effective when the bowel is empty.
  • Wash hands thoroughly with soap and warm water or use a hand sanitizer. Dry the hands thoroughly on a clean towel or paper towel.
  • Carefully remove the suppository from its wrapper.
  • If it is necessary to cut the suppository, use a clean, single-edge razor blade to slice it lengthwise.
  • Use a disposable glove, if desired.

2. Get ready to insert the suppository

Share on Pinterest

  • Dip the tip of the suppository in water, or apply a small amount of water-based lubricant, such as K-Y Jelly that is available to buy online. A lubricant helps the suppository more easily slide into the rectum.
  • Remove clothing from the lower half of the body.
  • Find the correct position. Either stand up with one foot on a chair or lie down on one side with the top leg bent slightly toward the stomach. Caregivers giving the suppository to another person often find it easier if the person is lying down.

3. Insert the suppository

Share on Pinterest

  • Relax the muscles of the buttocks and open the cheeks.
  • Gently insert the suppository into the anus, narrow end first.
  • Push it in about 1 inch for adults, or half an inch for infants.
  • In older children, push the suppository in approximately half to one inch, depending on their size.

4. Relax and clean up

Share on Pinterest

  • Sit or lie still for 10 minutes after inserting the suppository. Staying still allows time for the suppository to dissolve in the body. Parents may need to hold a child’s buttocks closed during this time.
  • Dispose of all materials, including the suppository wrapper and any tissue paper.
  • Wash the hands thoroughly with soap and warm water.

Try to avoid passing stool for up to 60 minutes after inserting the suppository, unless it is a laxative. Not passing stool gives the medication enough time to enter the bloodstream and start working.

Share on Pinterest

To place a suppository into the vagina, follow these tips:

1. Get prepared

  • Wash hands with soap and warm water, or use a hand sanitizer if these are not available. Dry the hands well on a clean towel or paper towel.
  • Unwrap the suppository, and place it in the accompanying applicator.
  • Either stand with the knees bent and feet apart or lie down with the knees bent toward the chest.

2. Insert the suppository

Share on Pinterest

  • Place the applicator into the vagina, as far as possible, without causing discomfort.
  • Press down on the plunger to push in the suppository.
  • Remove the applicator from the vagina, and dispose of it.

3. Relax and clean up

  • Lie down for 10 minutes to allow the medicine to enter the body.
  • Wash the hands once more with soap and warm water.

Consider using a sanitary towel for a few hours, as some of the suppository may leak out onto the underwear.

To place a suppository into the urethra try the following tips:

1. Get prepared

  • Empty the bladder.
  • Wash the hands with soap and warm water or use a hand sanitizer. Dry the hands thoroughly on a clean towel or paper towel.
  • Remove the applicator cover.

2. Insert the suppository

  • Stretch out the penis to open the urethra.
  • Place the applicator into the hole at the tip.
  • Push the button on the applicator and hold for 5 seconds.
  • Gently move the applicator from side to side to ensure the suppository has entered the urethra.
  • Remove the applicator.

3. Relax and clean up

  • Massage the stretched penis firmly for 10 to 15 seconds to allow the medicine to be absorbed.
  • Dispose of the applicator and any other materials.
  • Wash the hands once more with soap and warm water.

Suppositories are usually safe to use. Sometimes, some of the medication may leak out. To avoid a mess, people may want to wear a sanitary towel or incontinence pad.

Some people may experience irritation around the area where they inserted the suppository. If this is severe or persists, they should see a doctor.

Occasionally, the body may not absorb the medication delivered by a suppository as well as it does oral medications.

The following tips may help people who need to use suppositories:

  • Avoid exercise or vigorous movement for 60 minutes after inserting the medication.
  • Do not use petroleum jelly, such as Vaseline, to lubricate the suppository. This stops it from melting. Only use water, or a water-based lubricant.
  • Store suppositories in the refrigerator or another cool place, so they do not melt. Always follow the storage directions on the label.
  • A soft suppository can be difficult to insert. Gently squeeze it to see if it is firm enough. If not, harden the wrapped suppository by holding it under a flow of cold water. Or, place it in the refrigerator for a few minutes.
  • Trim fingernails before inserting suppositories. This prevents cuts and scrapes. Alternatively, wear a latex glove.
  • Some people may notice the suppository falls out. This can occur because they have not pushed it far enough into the rectum. Push the medication in about 1 inch.
  • Those who struggle to use suppositories should consider asking a partner or caregiver for help.
  • As with other medicines, avoid missing doses. Missed doses may reduce the effectiveness of the treatment.

Suppositories are helpful for people who cannot take medications by mouth.

People who have difficulty using suppositories should ask their doctor for advice. They should also talk to their doctor before using suppositories if they:

  • have had recent rectal surgery, prostate surgery, or vaginal treatment
  • have an irregular heartbeat

Although they may be unpleasant to use, rectal, vaginal, and urethral suppositories can be an effective way of delivering medication.

Instructions, after how long they work, dosage, composition

Date of publication: 06.10.2022 POSSIBLE SIDE EFFECTS. A SPECIALIST’S CONSULTATION IS NECESSARY. Antipyretic for adults Antipyretic for children Antipyretic candles s

Article content

  • Cefecon: composition
  • Cefecon: active substance
  • Cefecon suppositories: dosage
  • Cefecon: suppositories for newborns
  • Cefecon for teething
  • Cefecon N: how long does it take to work
  • Cefecon D: how long does it take to work
  • Summary 9 0016
  • Ask an expert about the topic of the article

It is no coincidence that autumn is nicknamed the “season of colds”. The warm summer period is leaving: holidays are ending, the air temperature is dropping, the day is getting shorter, and the workload is increasing. The body is rebuilt to a new mode and becomes vulnerable. It is estimated that annual autumn epidemics of viral diseases lead to 3-5 million cases of severe illness.

Bacteria and viruses attack the weakened immune system, causing a response – fever. It is sometimes difficult to deal with it, especially when it comes to children. Antipyretics come to the rescue, one of which will be discussed in this article.

Pharmacist Kristina Khokhrina will tell you about Cefecon, its composition, dosage, application and how long it takes to start working.

All products Tsefekon

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Tsefekon: composition

There are two types of candles against temperature Tsefekon: Tsefekon N and Tsefekon D (for children). Cefecon H is a combination drug containing caffeine, naproxen and salicylamide. It is used to treat and prevent fever in adults and children over 16 years of age. Cefecon D is paracetamol. It is used in children from 3 months to 12 years.

Cefecon: active ingredient

Both drugs have antipyretic, analgesic and anti-inflammatory effects, but this is achieved through different active ingredients. Cefecon N contains:

  • Caffeine is a psychoactive component to eliminate drowsiness and fatigue, as well as increase physical and mental activity.
  • Naproxen and salicylamide are anti-inflammatory ingredients that normalize body temperature and relieve pain.

Cefecon for Children contains paracetamol, a safe and well-tolerated antipyretic agent for children. Paracetamol is included in the list of clinical recommendations for the provision of emergency care for acute fever in children.

Cefecon suppositories: dosage

Cefecon is available in the form of suppositories – rectal suppositories. Note that suppositories are a safer dosage form than, for example, tablets. Suppositories cause fewer side effects because they do not enter the stomach, which means that nausea, vomiting and abdominal discomfort will not threaten patients. For the same reason, the effect of candles comes faster.

To use, it is necessary to remove the suppository from the packaging and insert it deep into the rectum, and then lie down for 30-40 minutes.

Cefecon H is used up to 3 times a day, but not more than 3 days in the fight against fever, and not more than 5 days in case of pain. Produced in a single dosage of 10 pieces per pack.

The dose of Cefecon for children is calculated depending on the weight and age of the child. So, for children from 1 to 3 years old weighing 11-16 kg, use 1 suppository of 100 mg. The interval between applications should be at least 6 hours, and the maximum dose should not exceed 60 mg/kg of the child’s weight. Available in 10 suppositories per pack in three dosages: 50, 100 and 250 mg.

Course duration: 3 days for fever and 5 days for pain. Candles are dispensed without a prescription, but it is still worth consulting with a doctor or pharmacist. The drug has contraindications, and an incorrectly calculated dose will lead to an overdose, the consequences of which will be severe.

Cefekon: suppositories for newborns

Newborns are children from the moment of birth until the 28th day of life. The use of Cefecon D during this period is possible, but only once and as directed by a doctor.

Suppositories are used in case of fever due to vaccinations, which are carried out up to 2 months. It is worth inserting a candle into the empty intestine, after warming it up in your hands.

Cefecon for teething

Teething in children begins at the age of 2 to 7 months and is accompanied not only by pain, but also by fever. In this case, Cefecon D will be an effective remedy that eliminates both violations. Candles will not affect the normal body temperature, so you should not be afraid of its excessive decrease.

Cefecon N: how long does it take to start working

Naproxen and salicylamide in Cefecon N allow you to quickly get rid of pain: the effect occurs within 30 minutes after application and lasts up to 8 hours. The anti-inflammatory effect develops within 1-2 weeks.

Cefecon D: how long does it take to act

The maximum effect of paracetamol in the composition of suppositories is achieved 2-3 hours after administration and lasts up to 6 hours.

Summary

  • In autumn, the body adjusts to a new regimen and becomes vulnerable
  • Cefekon anti-temperature suppositories are of two types: Cefekon N and Cefekon D (for children)
  • Cefecon N contains: caffeine, naproxen and salicylamide
  • Children’s Cefecon contains paracetamol
  • Cefecon is available in the form of suppositories – rectal suppositories
  • Cefecon N is used up to 3 times a day, no more than 3 days in the fight against fever, and no more than 5 days – with pain
  • The dose of Cefecon for children is calculated depending on the weight and age of the child
  • Cefecon D can be used for newborns, but only once and as prescribed by a doctor
  • Cefecon D will be an effective remedy for teething in children
  • The action of Cefecon N occurs already 30 minutes after application and lasts up to 8 hours
  • The maximum effect of Cefecon D is achieved 2-3 hours after administration and lasts up to 6 hours

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Suppositories in gynecology: types and features of use

For the treatment and prevention of many gynecological diseases, local drugs are often prescribed, for example, suppositories. What is the advantage of such medicines?

“Drugs that are injected into the natural cavities of the body are used in complex therapy for the treatment of adnexitis, oophoritis, cervical erosion, colpitis, vaginitis, with polycystic ovaries, endometriosis, to eliminate violations of the vaginal microflora. In addition, suppositories are actively prescribed before and after various surgical interventions, before childbirth or the installation of intrauterine devices.

What explains such a wide range of applications and doctors’ commitment to this dosage form? The fact is that preparations in the form of suppositories have a number of significant advantages: they quickly dissolve and begin to act in the pathological focus, while not only having a therapeutic effect, but also preventing the further spread of the infection. In addition, with this method of treatment, there are practically no side effects that are possible with oral medication. Prescribing drugs in the form of suppositories is especially important if the patient has a history of disorders in the functioning of the liver, kidneys, gastrointestinal tract, cardiovascular system, ”obstetrician-gynecologist, endocrinologist of the GIMed Family Health Clinic Lidia Sheygas draws attention.

Types of suppositories and their mechanism of action

Suppositories are divided into two large groups: vaginal and rectal. According to the form of the introduction of the candle, there are several types. Vaginal are most often round, oval, and also in the form of a cone. Rectal suppositories are produced mainly in the form of a cone.

The composition always contains a solid base (paraffin, gelatin, glycerin), it is she who creates and holds the shape of the suppository, and the active substance. A feature of these drugs is their ability to maintain a solid consistency in the external environment and quickly turn into a liquid inside the body.

The main therapeutic advantage of suppositories is that they not only locally affect the focus of inflammation, but also have a general healing effect. It is known that the area of ​​the vagina and rectum is supplied with a huge number of blood vessels, so the active medicinal components enter the bloodstream very quickly and actively circulate in the pelvic area, while carrying out not only a local therapeutic effect. Biologically available medicinal substances become within 30-60 minutes.

Such therapy quickly relieves the symptoms of the disease, does not affect the menstrual cycle, secretion of gonadotropic hormones, carbohydrate and lipid metabolism. Candles are administered quickly and painlessly, and the use of this group of medicines is rarely accompanied by allergic reactions.

Command staff

As part of a suppository, the active substance can be both synthetic and natural, and also include antibiotics, antiseptics, antifungal and antiviral components, vitamins, probiotics and other substances that help strengthen local immunity. The appointment depends on the pathogenic agent that caused the gynecological disease (viruses, bacteria, fungi or protozoa).

Most suppositories have a complex mechanism of action and can simultaneously relieve the inflammatory process and affect pathogens.

Antibacterial suppositories. The main active ingredient of such drugs are metronidazole, co-trixomazol, penicillins, macrolides. The use of antibacterial drugs always has its own characteristics. If used incorrectly, such drugs can cause allergic reactions, cause oppression of the normal microflora of the vagina and reduce local protective reserves.

Antifungal suppositories . The most famous drugs are fluconazole, clotrimazole, natamycin. The course of treatment depends on many factors, therefore it is determined individually.

Anti-inflammatory suppositories – the main component is non-steroidal anti-inflammatory drugs – diclofenac, ichthyol or indomethacin. They not only relieve inflammation and swelling, but also anesthetize.

Such drugs, from a biological point of view, inhibit the production of prostaglandins, which are produced in large quantities during the inflammatory process and cause pain.

Suppositories with steroidal anti-inflammatory drugs (prednisolone) are less commonly used in gynecological practice.

The therapeutic course of inflammatory diseases lasts up to ten days.

Antiviral suppositories (protiflazid, interferon alfa-2b) are used in clinical practice for the treatment of genital herpes and human papillomavirus (HPV) as part of complex treatment. The therapeutic course is long, the duration of therapy will be determined by the attending physician.

Hormone-based preparations (estriol) – contribute to the restoration of hormonal balance, the pH level in the vagina, suppress the inflammatory process, strengthen the natural barrier, reduce the risk of relapses. The course of treatment is long, determined individually by the doctor.

Candles with natural ingredients , which include sea buckthorn oil, cocoa, eucalyptus, extracts of medicinal herbs, coniferous trees, are prescribed for pregnant women, during lactation, as well as for older people and children.

Suppository Administration: General Rules

It is recommended to administer suppositories at night, preferably before bedtime. Before using rectal suppositories, it is necessary to empty the intestines. The manipulation is carried out lying on its side, bending the legs at the knees and pressing them to the chest. But vaginal suppositories are injected to the maximum depth while lying on your back. Special applicators that are attached to suppositories greatly facilitate the process. After the introduction, you need to be in a horizontal position for at least twenty minutes. This time is enough to dissolve the candle.

The use of the suppository is contraindicated in case of allergic reactions to the components of the preparation.