Piperacillin-Tazobactam Intravenous: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

piperacillin-tazobactam 2.25 gram intravenous solution

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piperacillin-tazobactam 40.5 gram intravenous solution

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piperacillin-tazobactam 4.5 gram intravenous solution

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piperacillin-tazobactam 3.375 gram intravenous solution

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piperacillin-tazobactam 4.5 gram intravenous solution

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This medicine is a white, vial

piperacillin-tazobactam 3.375 gram intravenous solution

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This medicine is a white, vial

piperacillin-tazobactam 4.5 gram intravenous solution

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This medicine is a white, vial

piperacillin-tazobactam 3. 375 gram intravenous solution

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This medicine is a white, vial

piperacillin-tazobactam 2.25 gram intravenous solution

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This medicine is a white, vial

piperacillin-tazobactam 2.25 gram intravenous solution

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This medicine is a white, vial

piperacillin-tazobactam 2.25 gram intravenous solution

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This medicine is a white, vial

piperacillin-tazobactam 2.25 gram intravenous solution

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This medicine is a white, vial

piperacillin-tazobactam 3.375 gram intravenous solution

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This medicine is a white, vial

piperacillin-tazobactam 4.5 gram intravenous solution

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This medicine is a white, vial

piperacillin-tazobactam 2.25 gram intravenous solution

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This medicine is a white, vial

piperacillin-tazobactam 4. 5 gram intravenous solution

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This medicine is a white, vial

piperacillin-tazobactam 2.25 gram intravenous solution

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This medicine is a white, vial

piperacillin-tazobactam 2.25 gram intravenous solution

Color: colorlessShape: Imprint:

This medicine is a white, vial

piperacillin-tazobactam 3.375 gram intravenous solution

Color: whiteShape: Imprint:

This medicine is a white, vial

piperacillin-tazobactam 2.25 gram intravenous solution

Color: colorlessShape: Imprint:

This medicine is a white, vial

piperacillin-tazobactam 3.375 gram intravenous solution

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This medicine is a white, vial

piperacillin-tazobactam 4.5 gram intravenous solution

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This medicine is a white, vial

piperacillin-tazobactam 3.375 gram intravenous solution

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This medicine is a white, vial

piperacillin-tazobactam 40. 5 gram intravenous solution

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This medicine is a white, vial

piperacillin-tazobactam 2.25 gram intravenous solution

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This medicine is a white, vial

piperacillin-tazobactam 2.25 gram intravenous solution

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This medicine is a white, vial

piperacillin-tazobactam 3.375 gram intravenous solution

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This medicine is a white, vial

piperacillin-tazobactam 2.25 gram intravenous solution

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This medicine is a white, vial

piperacillin-tazobactam 4.5 gram intravenous solution

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piperacillin-tazobactam 13.5 gram intravenous solution

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piperacillin-tazobactam 4.5 gram intravenous solution

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This medicine is a white, vial

piperacillin-tazobactam 4. 5 gram intravenous solution

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This medicine is a white, vial

piperacillin-tazobactam 3.375 gram intravenous solution

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This medicine is a white, vial

piperacillin-tazobactam 2.25 gram intravenous solution

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This medicine is a white, vial

piperacillin-tazobactam 2.25 gram intravenous solution

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This medicine is a white, vial

piperacillin-tazobactam 40.5 gram intravenous solution

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This medicine is a white, vial

piperacillin-tazobactam 4.5 gram intravenous solution

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This medicine is a white, vial

piperacillin-tazobactam 3.375 gram intravenous solution

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This medicine is a white, vial

piperacillin-tazobactam 2.25 gram intravenous solution

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This medicine is a white, vial

piperacillin-tazobactam 40. 5 gram intravenous solution

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This medicine is a white, vial

piperacillin-tazobactam 3.375 gram intravenous solution

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This medicine is a white, vial

piperacillin-tazobactam 4.5 gram intravenous solution

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This medicine is a white, vial

piperacillin-tazobactam 3.375 gram intravenous solution

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This medicine is a white, vial

piperacillin-tazobactam 4.5 gram intravenous solution

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This medicine is a white, vial

piperacillin-tazobactam 3.375 gram intravenous solution

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This medicine is a white, vial

piperacillin-tazobactam 2.25 gram intravenous solution

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This medicine is a white, vial

piperacillin-tazobactam 40.5 gram intravenous solution

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This medicine is a white, vial

piperacillin-tazobactam 40. 5 gram intravenous solution

Color: whiteShape: Imprint:

This medicine is a white, vial

piperacillin-tazobactam 3.375 gram intravenous solution

Color: whiteShape: Imprint:

This medicine is a white, vial

piperacillin-tazobactam 2.25 gram intravenous solution

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This medicine is a white, vial

piperacillin-tazobactam 2.25 gram intravenous solution

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This medicine is a white, vial

piperacillin-tazobactam 4.5 gram intravenous solution

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This medicine is a white, vial

piperacillin-tazobactam 4.5 gram intravenous solution

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This medicine is a white, vial

piperacillin-tazobactam 4.5 gram intravenous solution

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This medicine is a white, vial

piperacillin-tazobactam 3.375 gram intravenous solution

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This medicine is a white, vial

piperacillin-tazobactam 2. 25 gram intravenous solution

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This medicine is a white, vial

piperacillin-tazobactam 3.375 gram intravenous solution

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This medicine is a white, vial

piperacillin-tazobactam 4.5 gram intravenous solution

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This medicine is a white, vial

piperacillin-tazobactam 3.375 gram intravenous solution

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This medicine is a white, vial

Piperacillin/Tazobactam Injection 2,000 mg/250 mg, 3,000 mg/375 mg, 4,000 mg/500 mg – Health Information Library

For treating bacterial infection.

Brand Name(s): Zosyn

Generic Name: Piperacillin/Tazobactam

Instructions

This medicine is given as an IV injection into a vein.

Check the medicine before each use. If the liquid medicine has any particles in it, appears discolored, or if the vial appears damaged, do not use it.

Keep at room temperature until mixing. Refrigerate any extra mixed medicine until ready to use it.

Speak with your nurse or pharmacist about how long the medicine can be stored safely at room temperature or in the refrigerator before it needs to be discarded.

Never use any medicine that has expired.

Please ask your doctor, nurse, or pharmacist how to discard unused medicines safely.

Space doses evenly to keep a steady amount of medicine in the body.

If you miss a dose, contact your doctor for instructions.

Drug interactions can change how medicines work or increase risk for side effects. Tell your health care providers about all medicines taken. Include prescription and over-the-counter medicines, vitamins, and herbal medicines. Speak with your doctor or pharmacist before starting or stopping any medicine.

Tell your doctor if symptoms do not get better or if they get worse.

Keep using this medicine for the full number of days that it is prescribed. Do not stop the medicine even if you start to feel better.

Keep all appointments for medical exams and tests while on this medicine.

Cautions

Tell your doctor and pharmacist if you ever had an allergic reaction to a medicine.

Some patients taking this medicine have experienced serious side effects. Please speak with your doctor to understand the risks and benefits associated with this medicine.

Do not use the medication any more than instructed.

Contact your doctor if you develop any signs of a new infection such as fever, cough, sore throat, or chills.

Speak with your health care provider before receiving any vaccinations.

Please tell your doctor if you have moderate to severe diarrhea while on this medicine. Do not treat the diarrhea with over-the-counter diarrhea medicine.

Tell the doctor or pharmacist if you are pregnant, planning to be pregnant, or breastfeeding.

Ask your pharmacist how to properly throw away used needles or syringes.

Do not share this medicine with anyone who has not been prescribed this medicine.

Side Effects

The following is a list of some common side effects from this medicine. Please speak with your doctor about what you should do if you experience these or other side effects.

• agitated feeling or trouble sleeping
• constipation or diarrhea
• headaches
• pain, redness, swelling near injection
• nausea

Call your doctor or get medical help right away if you notice any of these more serious side effects:

• bleeding or bruising
• severe, watery or bloody diarrhea
• severe stomach or bowel pain
• blood in stool
• yeast infection of mouth
• vaginal itching or yeast infection

A few people may have an allergic reaction to this medicine. Symptoms can include difficulty breathing, skin rash, itching, swelling, or severe dizziness. If you notice any of these symptoms, seek medical help quickly.

Please speak with your doctor, nurse, or pharmacist if you have any questions about this medicine.

IMPORTANT NOTE: This document tells you briefly how to take your medicine, but it does not tell you all there is to know about it. Your doctor or pharmacist may give you other documents about your medicine. Please talk to them if you have any questions. Always follow their advice.

There is a more complete description of this medicine available in English. Scan this code on your smartphone or tablet or use the web address below. You can also ask your pharmacist for a printout. If you have any questions, please ask your pharmacist.

The display and use of this drug information is subject to Terms of Use.

https://api.meducation.com/V2.0/fdbpem/3050

Copyright(c) 2023 First Databank, Inc.

Selected from data included with permission and copyright by First DataBank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

Conditions of Use: The information in this database is intended to supplement, not substitute for the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. The display and use of this drug information is subject to express Terms of Use.

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Tazobactam (tazobactam): description, use, side effects

Tazobactam (tazobactam) is a powerful inhibitor of beta-lactamase, which is often used in combination with the antibiotic piperacillin to fight certain types of bacteria. This drug is widely used in medical practice to treat infections caused by strains of bacteria resistant to other antibiotics. Learn more about the uses and side effects of tazobactam.

Tazobactam is a beta-lactamase inhibitor antibiotic used in combination with other antibiotics to treat various infections. It has high activity against a wide range of bacteria, including many types of gram-positive and gram-negative microorganisms.

Tazobactam is especially effective when the infection is caused by bacteria that are resistant to other antibiotics. It is often used in the treatment of infections of the urinary tract, gastrointestinal tract, skin and soft tissues, lungs and other organs.

It should be noted that tazobactam is a prescription drug and should only be used as directed by a physician. Taking tazobactam can cause a variety of side effects, including injection site reactions, allergic reactions, diarrhea, nausea, and vomiting. If any unwanted symptoms appear, you should immediately consult a doctor.

In general, tazobactam is an important antibiotic that helps fight infections caused by drug-resistant bacteria. However, its use must be conscious and controlled by the doctor in order to avoid possible side effects and the development of bacterial resistance to this drug.

What is tazobactam?

Tazobactam is a drug that belongs to the class of beta-lactamase inhibitors. It is used in combination with the antibiotic piperacillin to treat infections caused by bacteria that produce beta-lactamase, such as gram-negative bacteria.

Tazobactam works by interfering with the action of beta-lactamases, an enzyme that breaks down beta-lactam antibiotics, rendering them ineffective. This allows piperacillin to be active and fight infection.

Tazobactam is available as a powder for solution for injection. It is commonly used in a hospital setting and can be used to treat urinary tract infections, bronchitis, pneumonia, acute sinusitis, and other infections caused by piperacillin-susceptible organisms.

Tazobactam is generally well tolerated by patients, but side effects such as diarrhea, nausea, vomiting, allergic reactions and changes in liver enzymes are possible. Before using tazobactam, you should consult with your doctor and read the instructions for use.

Primary use of tazobactam

Tazobactam is a beta-lactamase inhibitor used in combination with antibiotics to fight infections caused by Gram-negative bacteria. The main use of tazobactam is associated with its ability to enhance the activity of antibiotics and prevent their destruction by beta-lactamases.

Tazobactam is widely used in clinical practice for the treatment of urinary tract infections, bronchitis, pneumonia, acute abdominal infections and other infections caused by gram-negative bacteria, including various strains of E. coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and others.

Preparations containing tazobactam can be used in both inpatient and outpatient settings. They have a wide spectrum of activity and can be effective for various types of infections. However, before starting the use of tazobactam, it is necessary to conduct an antibiogram to determine the sensitivity of the pathogen to this drug.

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How does tazobactam work?

Tazobactam is a beta-lactamase inhibitor, which means that it blocks the activity of enzymes that break down beta-lactam antibiotics. Thus, tazobactam enhances the action of antibiotics and allows them to effectively fight infection.

Tazobactam is broad spectrum active against many Gram positive and Gram negative bacteria including Staphylococcus, Streptococcus, Escherichia, Escherichia coli, Proteus and Pseudomonas.

In combination with antibiotics such as piperacillin or ceftazidime, tazobactam exhibits a synergistic effect, meaning that its presence enhances the bactericidal action of the antibiotic. It is especially useful in treating infections caused by beta-lactamase producing bacteria.

Tazobactam is usually used in combination with other antibiotics to treat serious infections such as pneumonia, sepsis, and urinary tract infections. It can be used as an injection or intravenous injection. The dosage and duration of treatment depend on the type of infection and the patient’s response to the drug.

How to take tazobactam?

Tazobactam is an antibiotic used in combination with other drugs to treat infections. The dosage and route of administration of tazobactam should be determined by the physician, depending on the type of infection, its severity, and the individual patient.

Tazobactam is usually taken intravenously, that is, injected directly into a vein. The frequency and duration of administration may vary depending on the specific situation, but usually the drug is used every 6-8 hours. It is important to observe the regularity of taking and not to miss the prescribed doses.

The dosage of tazobactam may vary depending on the age and weight of the patient and the type of infection. To determine the optimal dose, you should consult a doctor or read the instructions for the drug.

It is important to remember that self-medication with tazobactam is unacceptable. The drug must be prescribed and monitored by a doctor who will monitor the effectiveness of treatment and possible side effects.

What are the possible side effects of taking tazobactam?

Tazobactam is an antibiotic that can cause various side effects in patients. Some of these may be mild and temporary, while others may be more severe and require medical attention.

One of the most common side effects of tazobactam is diarrhea. Patients may experience frequent and loose stools, which can lead to dehydration. In the event of diarrhea, a doctor should be consulted for advice and possible treatment.

Another side effect associated with taking tazobactam is an allergic reaction. Patients may experience itching, rash, swelling of the face, throat, or tongue. In the event of an allergic reaction, you should immediately consult a doctor or call an ambulance.

Tazobactam can also cause digestive problems such as nausea and vomiting. These symptoms may be temporary and disappear after the end of the drug. However, if nausea and vomiting persist or worsen, a doctor should be consulted.

Other possible side effects of tazobactam include headache, bone marrow depression, increased sensitivity to sunlight, elevated liver enzymes, and changes in blood pressure. If you experience these or any other unusual symptoms, be sure to tell your doctor.

In general, tazobactam is an effective medicine, but like all medicines, it can cause side effects. Patients should be attentive to their condition and consult a doctor in case of any unusual symptoms or complications.

What are the contraindications for tazobactam?

Tazobactam is a powerful antibiotic, but it also has some contraindications that must be taken into account when using it.

First of all, tazobactam is contraindicated in people with a known allergy to this drug or to other beta-lactam antibiotics such as penicillins or cephalosporins. An allergic reaction to tazobactam can cause hives, laryngeal edema, or even anaphylactic shock, so it is important to be careful when prescribing this drug to a patient.

In addition, tazobactam is not recommended if you have a history of serious side effects with this antibiotic, such as seizures or impaired kidney function. In such cases, the use of tazobactam can be dangerous and requires special care.

Tazobactam is also not recommended for pregnant women, especially in the first trimester of pregnancy, as its safety to the fetus has not been established. However, if it is necessary to use tazobactam in pregnant women, the doctor may decide on its use, taking into account the benefit to the mother and the potential risk to the fetus.

It is also important to consider possible interactions of tazobactam with other drugs. For example, some antibiotics may increase its effect, while others may decrease its effectiveness. Therefore, before using tazobactam, it is necessary to consult a doctor and inform him about all the medicines taken.

Interactions of tazobactam with other drugs

Tazobactam may interact with some drugs, which may lead to a change in their effectiveness or side effects. Before starting treatment with tazobactam, tell your doctor about all medications you are taking, including prescription, over-the-counter, and herbal medications.

Simultaneous use of tazobactam with aminoglycosides such as gentamicin or tobramycin may increase their toxic effects on the kidneys and hearing. Therefore, the doctor may decide to reduce the dose of aminoglycosides or prescribe other antibiotics.

Tazobactam may increase the concentration of methotrexate in the blood, which may increase the risk of its toxic effects. With the simultaneous use of these drugs, it is necessary to carefully monitor the level of methotrexate in the body and, if necessary, adjust its dose.

Antifungal drugs such as fluconazole or voriconazole may increase the blood concentration of tazobactam, which may increase its action and cause side effects. With the simultaneous use of these drugs, it is necessary to carefully monitor the patient’s condition and, if necessary, adjust the dose of tazobactam.

Tazobactam may increase the effect of anticoagulants such as warfarin, which may lead to increased clotting time and risk of bleeding. With the simultaneous use of these drugs, it is necessary to carefully monitor the state of blood clotting and, if necessary, adjust the dose of anticoagulants.

Q&A:

What is tazobactam?

Tazobactam is an antibiotic used in combination with other drugs to treat infections. It belongs to the class of beta-lactamase inhibitors, which help protect antibiotics from being destroyed by bacteria.

How is tazobactam used?

Tazobactam is used with other antibiotics to treat infections caused by bacteria that are resistant to other antibiotics. It can be given intravenously, usually in a hospital setting.

What infections can be treated with tazobactam?

Tazobactam is used to treat various infections such as urinary tract infections, lung infections, skin and soft tissue infections, abdominal infections, and others. However, it is not effective against viral infections such as the flu or the common cold.

What side effects can tazobactam cause?

Tazobactam can cause various side effects, including allergic reactions, diarrhea, nausea, vomiting, headache, elevated liver enzymes, etc. If you experience any side effects while using tazobactam, you should consult your doctor.

What preparations contain tazobactam?

Tazobactam is found in various combination products, such as Tazocin, Timentin, etc. They combine tazobactam with other antibiotics to enhance the effect of treating infections.

Can tazobactam be used during pregnancy?

The use of tazobactam during pregnancy may not be safe for the baby. Therefore, before using this drug, it is necessary to consult a doctor and weigh the benefits and risks.

How long should I take tazobactam?

How long you take tazobactam depends on the type and severity of the infection and your doctor’s advice. The drug is usually taken over several days to several weeks. It is important to take the drug in accordance with the doctor’s prescription and not stop taking it earlier than the specified period.

Important information about tazobactam

Tazobactam is a medicine used in combination with antibiotics to treat infections caused by bacteria that are usually resistant to other antibiotics.

Tazobactam belongs to a class of beta-lactamase inhibitors that prevent the destruction of antibiotics by bacterial enzymes. This allows you to enhance the effectiveness of antibiotics and fight infection more effectively.

The use of tazobactam is especially important in cases where bacteria are resistant to other antibiotics. It is widely used to treat urinary tract infections, bronchitis, pneumonia, and skin and soft tissue infections.

Tazobactam is usually given intravenously as an injection or infusion. The dosage and duration of treatment are determined by the doctor depending on the type of infection, its severity and other factors.

Side effects such as allergic reactions, diarrhea, nausea, vomiting, headache and increased liver activity may occur when using tazobactam. If you experience any unusual symptoms or side effects, contact your doctor.

It is important to remember that tazobactam is a prescription drug and should only be used with a doctor’s prescription. It is not recommended to self-medicate or change the dosage without consulting a medical professional.

Related video:

instructions for use, analogues, articles

Piperacillin is a semi-synthetic broad spectrum bactericidal antibiotic. The mechanism of action is based on inhibition of the synthesis of the bacterial cell wall membrane.

Tazobactam is a sulfonic derivative of triazolmethylpenicillanic acid. The mechanism of action is the inhibition of many beta-lactamases, including plasmid and chromosomal beta-lactamases, which cause bacterial resistance to penicillins and cephalosporins. Tazobactam significantly enhances antimicrobial activity and expands the spectrum of antibiotic action.

The preparation is active against the following Gram-negative bacteria:

Escherichia coli, Citrobacter spp. (including Citrobacter freundii, Citrobacter diversus), Klebsiella spp. (including Klebsiella oxytoca, Klebsiella pneumoniae), Enterobacter spp. (including Enterobacter cloaca, Enterobacter aerogenes), Proteus vulgaris, Proteus mirabilis, Providencia rettgery, Providencia stuartii, Plesiomonas shigelloides, Morganella morganii, Serratia spp. (including Serratia marcescens, Serratia liquifaciens), Salmonella spp. , Shigella spp., Pseudomonas aeruginosa and other Pseudomonas spp. (including Pseudomonas cepacia, Pseudomonas fluorescens), Xanthamonas maltophilia, Neisseria gonorrhoeae, Neisseria meningitidis, Moraxella spp. (including Branhamella catarrhalis), Acinetobacter spp., Haemophilus influenzae, Haemophilus parainfluenza, Pasteurella multocida, Yersinia spp., Campylobacter spp., Gardnerella vaginalis.

The drug effectively affects the following strains of gram-positive bacteria:

Streptococcus spp. (including Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus bovis, Streptococcus agalactiae, Streptococcus spp. viridans groups C and G subgroups), Enterococcus spp. (Enterococcus faecalis, Enterococcus faecium), Staphylococcus aureus (methicillin sensitive), Staphylococcus saprophyticus, Staphylococcus epidermidis (coagulase negative), Listeria monocytogenes, Nocardia spp.

The preparation is also active against anaerobic bacteria:

Bacteroides spp. (Bacteroides bivius, Bacteroides disiens, Bacteroides capillosus, Bacteroides melaninogenicus, Bacteroides oralis), subgroups of Bacteroides fragilis eptostreptococcus spp., Fusobacterium spp. ., Eubacterium spp., Clostridium spp. (including Clostridium difficile, Clostridium perfringens), Veilonella spp. and Actynomyces spp.

Pharmacokinetics:

With intravenous administration of the drug, the maximum concentration is reached immediately. Communication with plasma proteins of piperacillin and tazobactam is the same – 30%, distribution in tissues is 50-100% of plasma concentration. The drug is found in many body fluids and tissues: intestinal mucosa, gallbladder, bile, lungs, uterus, ovaries, fallopian tubes, bones.

Piperacillin is metabolized to an inactive desmethyl metabolite, tazobactam to an inactive metabolite.

The drug is excreted mainly by the kidneys. The half-life is 0.7-1.2 hours, with a decrease in creatinine clearance, it increases.

Infections of the lower respiratory tract, urinary tract, skin and soft tissues, bones and joints, intraabdobinal, gynecological, mixed infections, septicemia, bacterial infections with neutropenia (in combination with aminoglycosides)

• Hypersensitivity to beta-lactam antibiotics
• Hypersensitivity to beta-lactamase inhibitors
• Children under 2 years old
• Lactation

Caution:

• Childhood
• Pregnancy
• Bleeding, including history
• Cystic fibrosis (risk of hyperthermia)
• Pseudomembranous colitis
• Chronic renal failure
• Concomitant use of anticoagulants
• Hypokalemia

The drug is administered intravenously by stream over 3-4 minutes or by drip over 30 minutes.

For adults and children over 12 years of age with normal renal function, the dose is 4.5 g (4 g piperacillin/0.5 g tazobactam) every 8 hours.

For the treatment of children 2 to 12 years of age with neutropenia, the dose is calculated based on body weight: 90 mg (80 mg piperacillin/10 mg tazobactam) per 1 kg of body weight. The drug is administered every 6 hours in combination with an appropriate dose of aminoglycoside.

For patients on hemodialysis, the daily dose of the drug should not exceed 8 g of piperacillin / 1 g of tazobactam.

Treatment should be carried out for at least 5 days, but not more than 14 days.

• Allergic reactions, including anaphylactic shock
• Abdominal pain, nausea, vomiting, dyspepsia
• Hepatitis, jaundice
• Stomatitis
• Bleeding
• Interstitial nephritis, renal failure
• Headache, insomnia, convulsions
• Lowering blood pressure, “hot flashes”
• On the part of laboratory parameters: hypokalemia, transient leukopenia, eosinophilia, thrombocytopenia, positive Coombs reaction, transient increase in liver transaminases and alkaline phosphatase.
• Local reactions (phlebitis, thrombophlebitis, redness and induration at the injection site)
• Fungal superinfections

Co-administration with probenecid increases the half-life of piperacillin and tazobactam.

Co-administration with vecuronium bromide may result in more prolonged neuromuscular blockade.

The use of high doses of heparin, indirect anticoagulants increases the risk of bleeding.

Piperacillin delays the excretion of methotrexate from the body, which may increase its toxic effect.

The drug should not be mixed in the same syringe or dropper with other drugs.

Do not add to sodium bicarbonate solution or to blood or serum preparations.

Pregnancy and lactation

Piperacillin and tazobactam penetrate the placental barrier, so the drug is prescribed only if the expected benefit to the mother outweighs the possible risk to the fetus.

Piperacillin is secreted in breast milk, therefore it is necessary to stop breastfeeding during the period of treatment with the drug.