Tizanidine narcotic. Tizanidine: Understanding Its Uses, Addiction Potential, and Treatment Options
What is Tizanidine used for. How does Tizanidine work in the body. Is Tizanidine addictive or considered a narcotic. What are the side effects and risks of Tizanidine dependence. How should one safely discontinue Tizanidine use.
What is Tizanidine and How Does It Work?
Tizanidine, available in both generic and brand name (Zanaflex) forms, is a muscle relaxant primarily used to treat muscle spasms associated with spinal cord injuries and Multiple Sclerosis (MS). It works by acting on the central nervous system to prevent muscle spasms from occurring.
How does Tizanidine affect the body? Rather than directly impacting muscle fibers, Tizanidine influences the nervous system. This mechanism helps protect muscles from damage while providing relief from spasms. By slowing impulses in the brain, it allows muscles to relax, offering significant comfort and reducing the risk of injury due to sudden muscle contractions.
Primary Uses of Tizanidine
- Treating muscle spasms in MS patients
- Managing spasticity in individuals with spinal cord injuries
- Alleviating muscle tightening and associated pain
Can Tizanidine be used for other conditions? While its primary use is for MS and spinal cord injury-related muscle spasms, some doctors may prescribe Tizanidine off-label for other ailments. These may include:
- Insomnia
- Migraine headaches
- Back pain
Tizanidine Administration and Absorption
Tizanidine is available in two forms: capsules and tablets. The body responds differently to each version, with varying absorption rates that can impact the effectiveness in controlling muscle spasms.
For individuals who have difficulty swallowing, is there an alternative method of administration? Under a doctor’s guidance, the capsule may be opened and its contents mixed with applesauce or pudding. However, this approach can affect absorption rates, so it should only be done under medical supervision.
The Addiction Potential of Tizanidine
Despite not being classified as a narcotic, Tizanidine can be addictive. Several factors increase the risk of addiction:
- Taking Tizanidine alongside narcotics
- Consuming higher doses than prescribed
- Continuing use after it’s no longer medically necessary
Why is Tizanidine sometimes mistakenly perceived as non-addictive? The misconception stems from its mechanism of action. Unlike narcotics that bind directly to pain receptors, Tizanidine blocks nerve receptors at the muscle level. This difference can lead to a false sense of security regarding its potential for dependence.
Side Effects and Signs of Tizanidine Dependence
Tizanidine use can lead to various side effects, some of which are normal and typically subside as the body adjusts to the medication. However, prolonged or severe side effects should be reported to a healthcare provider.
Common Side Effects
- Weakness, dizziness, or drowsiness
- Tingling sensations in extremities
- Nervousness or depression
- Gastrointestinal issues (constipation, diarrhea, stomach pain)
- Dry mouth
- Increased muscle spasms or sweating
Severe Side Effects Requiring Immediate Medical Attention
- Unexplained cold or flu symptoms
- Extreme or constant tiredness
- Abnormal bruising or bleeding
- Vision changes or yellowing of the eyes
- Hallucinations
- Loss of appetite
How can one recognize signs of Tizanidine dependence? If you experience withdrawal symptoms when reducing your usual dosage, it may indicate that your body has become dependent on the medication. These symptoms can include dizziness, dry mouth, heart palpitations, sweating, and anxiety.
Tizanidine vs. Narcotics: Understanding the Difference
While Tizanidine can lead to dependence, it is not classified as a narcotic. The primary distinction lies in its mechanism of action within the body.
How does Tizanidine differ from narcotics in terms of pain management? Tizanidine blocks nerve receptors at the muscle level, whereas narcotics bind directly to pain receptors. This fundamental difference in action contributes to Tizanidine’s classification as a non-narcotic substance.
Discontinuing Tizanidine: Withdrawal and Safety Considerations
Abruptly stopping Tizanidine use can lead to withdrawal symptoms, which vary from person to person. To minimize these effects, most healthcare providers recommend a gradual tapering of the medication.
Potential Withdrawal Symptoms
- Dizziness
- Anxiety
- Blood pressure changes
- Muscle stiffening
- Heart rate fluctuations
What is the safest way to stop taking Tizanidine? A controlled, gradual reduction in dosage under medical supervision is typically the safest approach. This method can help minimize or even prevent withdrawal symptoms. In severe cases, additional medications may be prescribed to manage withdrawal effects.
Treatment Options for Tizanidine Addiction and Dependence
Addressing Tizanidine addiction or dependence requires a comprehensive approach, often involving medical supervision and support.
Key Components of Treatment
- Medical detoxification: Safely managing withdrawal symptoms
- Psychological counseling: Addressing underlying issues contributing to dependence
- Behavioral therapy: Developing coping strategies and preventing relapse
- Support groups: Connecting with others facing similar challenges
- Alternative pain management strategies: Exploring non-pharmacological options
Are there specialized facilities for treating Tizanidine addiction? Yes, many addiction treatment centers offer programs specifically designed to address Tizanidine dependence. These facilities provide comprehensive care, combining medical management with psychological support to help individuals overcome their addiction and develop healthier coping mechanisms.
Preventing Tizanidine Misuse and Addiction
While Tizanidine can be an effective treatment for muscle spasms, taking precautions to prevent misuse and addiction is crucial.
Strategies for Safe Tizanidine Use
- Adhering strictly to prescribed dosages
- Avoiding concurrent use with narcotics or other central nervous system depressants
- Regular check-ins with healthcare providers to assess ongoing need and effectiveness
- Being aware of potential signs of dependence
- Exploring alternative treatments for long-term management of chronic conditions
How can patients and healthcare providers work together to minimize the risk of Tizanidine addiction? Open communication is key. Patients should be encouraged to discuss any concerns or side effects with their healthcare providers. In turn, healthcare professionals should regularly assess the necessity of continued Tizanidine use and explore alternative treatments when appropriate.
By understanding the potential risks associated with Tizanidine use and implementing proper safeguards, patients can benefit from its therapeutic effects while minimizing the likelihood of developing dependence or addiction.
What Is Tizanidine? Abuse, Addiction, and Treatment
Home » What Is Tizanidine? Abuse, Addiction, and Treatment
Tizanidine is an oral drug that is available both in generic and brand name. The brand name version is called Zanaflex. It is a type of muscle relaxant used for very specific types of muscle spasms. These are muscle spasms caused in people with spinal cord injuries and Multiple Sclerosis.
What does Tizanidine do?
Tizanidine works on the central nervous system to stop muscle spasms from occurring. When you have a spinal cord injury or Multiple Sclerosis, you may not have full control over your muscles. Impulses from your brain can cause sudden and sometimes harmful muscle spasms. These sudden jerks have been known to be so strong that they can break bones, damaged tendons, and more.
The medication does not impact the muscle fibers directly, rather it affects the nervous system instead. This helps protect the muscles from damage, while also giving them a break. With MS and spinal cord injuries, some patients experience muscle tightening which can be painful. Tizanidine has the benefit of reducing some pain associated with muscle spasms and it doesn’t require any adjustments in dosing due to liver disease.
What is Tizanidine used for?
It is most widely used to treat muscle spasms associated with Multiple Sclerosis (MS). Tizanidine is one of many drugs that act on the central nervous system to alleviate uncontrollable muscle spasms. It slows impulses in the brain that can allow the muscles to relax. This gives significant comfort and decreases the chances of injury due to muscle spasms.
Tizanidine is an oral drug that can be taken either as a capsule or a tablet. The body responds to each version of the drug differently. The absorption rates are different and can even impact the rates of muscle spasms. For people who struggle to swallow, the doctor may have that individual open the capsule and put it in something like applesauce or pudding. Because this impacts absorption it’s important to only do this under the direction of your doctor.
In some cases, doctors may prescribe Tizanidine for other ailments and purposes. There is some evidence that off-label use of Tizanidine is effective to treat other conditions. Tizanidine may be prescribed for insomnia, migraine headaches, and even back pain.
Is Tizanidine Addictive?
Just Google Tizanidine addiction and you’ll see that there are many facilities that treat Tizanidine addiction. So yes, it can be addictive. Some of the risk factors for addiction include taking it alongside narcotics, taking higher doses than prescribed, and taking it after you no longer need it. All of these factors increase the risk of addiction.
Is Tizanidine a Narcotic?
The greatest appeal to many people who need help with muscle spasms is that Tizanidine is not a narcotic. While Tizanidine is non-narcotic, it does lead some people to become dependent on it. What differentiates it from a narcotic is the way it works in your body. It blocks nerve receptors at the muscle level instead of binding directly to pain receptors. This causes a false perception that one cannot become dependent on Tizanidine.
Side Effects of Tizanidine/Dependence
Doctors are very careful to prescribe small doses of Tizanidine at first to reduce the likelihood of side effects. Some side effects are normal but should go away after your body is used to the medication. If you experience any of these side effects for prolonged periods or if they are severe, it’s important to talk with your doctor. He or she may recommend a lower dose or a different medication.
- weakness, dizziness, or drowsiness
- tingling sensation in the arms, legs, hands, and feet
- nervousness or depression
- constipation, diarrhea, or stomach pain
- vomiting or dry mouth increased muscle spasms or sweating
Additionally, the symptoms below are reasons to call your doctor right away.
- unexplained cold or flu symptoms
- extreme or constant tiredness
- abnormal bruising or bleeding
- vision changes or yellowing of the eyes
- hallucinations
- no appetite
Signs of dependence on Tizanidine vary. Typically, if you drop your dosing below your usual amount and experience withdrawal symptoms, you’ll know your body is dependent. Some of these symptoms include dizziness, dry mouth, heart palpitations, sweating, anxiety, and more.
What Happens If I Stop Taking Tizanidine?
Most doctors will wean you off Tizanidine instead of having you quit cold turkey. Withdrawal symptoms vary from person to person. They can include dizziness, anxiety, blood pressure changes, muscle stiffening, heart rate changes, and more. By weaning off the medication, you may not experience any of these symptoms. In extreme cases, with some of the worst side effects, doctors may need to give you something to help you come off the medicine.
Withdrawal symptoms are typically seen in people who have been using very high doses of Tizanidine and especially those who use it alongside narcotics. It is much safer to use it at lower doses that have been prescribed by your doctor than to take it in higher doses.
Your doctor will likely use dose titration to wean you off Tizanidine slowly. This reduces the occurrence of harmful side effects.
Alternatives to Tizanidine
If you need medication to reduce muscle spasms, there are many options on the market. Your doctor will help you decide the best option for you based on your medical history, types of spasms, allergies, current medications, etc. Some common alternatives are Zanaflex, Soma, Valium, and Flexeril. These medications are all used for different purposes and help with muscle spasms in different ways. Some of them work directly on the muscle fibers, while others are like Tizanidine and work on the nervous system instead.
Getting Help
If you become addicted to Tizanidine and need help, contact your doctor or a detox center near you that can help you wean off and manage withdrawal symptoms. It’s important to only use Tizanidine as directed and to use caution when pairing it with other medications. Let your doctor know about every medicine or herbal product you are taking when you start on Tizanidine. This will help them decide between tablet and capsule and the best dosing.
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Tizanidine – description of the substance, pharmacology, use, contraindications, formula
Contents
Structural formula
Russian name
English name
Latin name
chemical name
Gross formula
Pharmacological group of the substance Tizanidine
Nosological classification
CAS code
pharmachologic effect
Characteristic
Pharmacology
The use of the substance Tizanidin
Contraindications
Use during pregnancy and lactation
Side effects of tizanidine
Interaction
Overdose
Dosage and administration
Precautionary measures
Information sources
Trade names with the active substance Tizanidine
Structural formula
Russian name
Tizanidin
English name
Tizanidine
Latin name
Tizanidinum ( born Tizanidini)
Chemical name
5-Chloro-N-(4,5-dihydro-1H-imidazole- 2-yl)-2,1,3-benzothiadiazol-4-amine (as hydrochloride)
Gross formula
C 9 H 8 ClN 5 S
Pharmacological substance group Tizanidin
Alpha-agonists
Drugs affecting neuromuscular transmission
Nosological classification
ICD-10 code list
CAS code
51322-75-9
Pharmacological action
Pharmacological action –
muscle relaxant , central .
Characteristics
White or almost white crystalline powder, odorless or with a slight characteristic odor. Slightly soluble in water and methanol, solubility in water decreases with increasing pH.
Pharmacology
Excites alpha 2 -adrenergic receptors, mainly at the level of the spinal cord; reduces the release of excitatory amino acids from the intermediate neurons of the spinal cord, selectively suppresses the polysynaptic mechanisms responsible for muscle hypertonicity. Relaxes skeletal muscles in chronic spastic conditions of spinal and cerebral origin, eliminates acute painful muscle spasms and clonic convulsions. Reduces muscle resistance during passive movements, increases the strength of voluntary muscle contractions.
After oral administration, it is rapidly and almost completely absorbed. Absolute bioavailability is approximately 40%. max “> C max is achieved in 1-2 hours. Plasma protein binding is about 30%. Biotransformed in the liver with the participation of the CYP1A2 isoenzyme to inactive or inactive metabolites. Excreted by 70% in the urine. T 1/2 – 3-5 hours
Application of the substance Tizanidine
Painful muscle spasms in diseases of the spine (including osteochondrosis, spondylosis, syringomyelia, hemiplegia, cervical and lumbar syndromes), after surgery for a herniated disc or osteoarthritis of the hip, spasticity and pain caused by neurological diseases: multiple sclerosis, chronic myelopathy, degenerative diseases of the spinal cord, cerebrovascular accidents, stroke, traumatic brain injury, cerebral palsy, convulsions of central origin.
Contraindications
Hypersensitivity, severe liver and kidney failure, pregnancy, lactation, childhood.
Pregnancy and Lactation Use
FDA Fetal Category C.
Breastfeeding should be discontinued during treatment (it is unknown if tizanidine is excreted in breast milk).
Side effects of the substance Tizanidine
From the side of the nervous system and sensory organs: drowsiness, fatigue, dizziness or vertigo, muscle weakness, anxiety, sleep disturbances, hallucinations.
From the CCC and blood (hematopoiesis, hemostasis): slight decrease in blood pressure (at low doses) or arterial hypertension, bradycardia.
From the gastrointestinal tract: dry mouth, nausea, gastrointestinal disorders, temporary increase in serum transaminase activity.
Interactions
Antihypertensive drugs, including diuretics, increase hypotension and bradycardia. Alcohol and sedatives deepen the depressive effect.
Overdose
Symptoms: nausea, vomiting, lowering blood pressure, dizziness, miosis, respiratory failure, coma.
Treatment: gastric lavage, activated charcoal, forced diuresis, maintenance of vital functions.
Dosage and administration
Inside. Dosing regimen should be selected individually. Tizanidine has a narrow therapeutic index and high variability in plasma levels of tizanidine in patients, so careful dose selection is required. Initial dose – 2-4 mg 3 times a day, in severe cases – an additional 2-4 mg at night. In case of neurologically caused spastic conditions, the initial dose should not exceed 6 mg per day in 3 doses with a gradual increase by 2-4 mg at intervals of 3-4 days – up to a week. The optimal therapeutic effect is usually achieved at a dose of 12-24 mg / day in 3-4 doses at regular intervals. Do not exceed a dose of 36 mg / day.
Precautions
Periodic monitoring of liver and kidney function is necessary and dose reduction if they worsen. A continuous increase in the activity of transaminases in the blood requires discontinuation. Due to possible drowsiness and weakness, it is recommended to limit the appointment to persons whose work requires a quick physical and mental reaction (operators, drivers of vehicles, etc. ).
Generalized materials www.grls.rosminzdrav.ru, 2014–2016.
Trade names with the active ingredient Tizanidine
Reset filters
Lek. form
All lek. modified release capsule forms substance-powder tablets
Dosage
All dosages 2 mg 250-1000 g 4 mg 6 mg No dosage
Manufacturer
All manufacturers Avexima Sibir LLC Berezovsky Pharmaceutical Plant CJSC (CJSC “BFZ”) Veropharm JSC Veropharm JSC J.P.En. Pharma Pvt. Irbit Chemical and Pharmaceutical Plant Novartis Neva OJSC Novartis Saglik LLC Gida ve Tarim Yuryunleri Sanayi ve Ticaret A.S. Novartis Pharmaceutical Ozone LLC Sun Pharmaceutical Industries Ltd. North Star NAO Simpeks Pharma Teva Pharmaceutical Plant JSC Teva Pharmaceutical Plant Private Co. Ltd Farmak
Tizanidine – description of the substance, pharmacology, use, contraindications, formula
Contents
Structural formula
Russian name
English name
Latin name
chemical name
Gross formula
Pharmacological group of the substance Tizanidine
Nosological classification
CAS code
pharmachologic effect
Characteristic
Pharmacology
The use of the substance Tizanidin
Contraindications
Use during pregnancy and lactation
Side effects of tizanidine
Interaction
Overdose
Dosage and administration
Precautionary measures
Information sources
Trade names with the active substance Tizanidine
Structural formula
Russian name
Tizanidin
English name
Tizanidine
Latin name
Tizanidinum ( born Tizanidini)
Chemical name
5-Chloro-N-(4,5-dihydro-1H-imidazole- 2-yl)-2,1,3-benzothiadiazol-4-amine (as hydrochloride)
Gross formula
C 9 H 8 ClN 5 S
Pharmacological substance group Tizanidin
Alpha-agonists
Drugs affecting neuromuscular transmission
Nosological classification
ICD-10 code list
CAS code
51322-75-9
Pharmacological action
Pharmacological action –
muscle relaxant , central .
Characteristics
White or almost white crystalline powder, odorless or with a slight characteristic odor. Slightly soluble in water and methanol, solubility in water decreases with increasing pH.
Pharmacology
Excites alpha 2 -adrenergic receptors, mainly at the level of the spinal cord; reduces the release of excitatory amino acids from the intermediate neurons of the spinal cord, selectively suppresses the polysynaptic mechanisms responsible for muscle hypertonicity. Relaxes skeletal muscles in chronic spastic conditions of spinal and cerebral origin, eliminates acute painful muscle spasms and clonic convulsions. Reduces muscle resistance during passive movements, increases the strength of voluntary muscle contractions.
After oral administration, it is rapidly and almost completely absorbed. Absolute bioavailability is approximately 40%. max “> C max is achieved in 1-2 hours. Plasma protein binding is about 30%. Biotransformed in the liver with the participation of the CYP1A2 isoenzyme to inactive or inactive metabolites. Excreted by 70% in the urine. T 1/2 – 3-5 hours
Application of the substance Tizanidine
Painful muscle spasms in diseases of the spine (including osteochondrosis, spondylosis, syringomyelia, hemiplegia, cervical and lumbar syndromes), after surgery for a herniated disc or osteoarthritis of the hip, spasticity and pain caused by neurological diseases: multiple sclerosis, chronic myelopathy, degenerative diseases of the spinal cord, cerebrovascular accidents, stroke, traumatic brain injury, cerebral palsy, convulsions of central origin.
Contraindications
Hypersensitivity, severe liver and kidney failure, pregnancy, lactation, childhood.
Pregnancy and Lactation Use
FDA Fetal Category C.
Breastfeeding should be discontinued during treatment (it is unknown if tizanidine is excreted in breast milk).
Side effects of the substance Tizanidine
From the side of the nervous system and sensory organs: drowsiness, fatigue, dizziness or vertigo, muscle weakness, anxiety, sleep disturbances, hallucinations.
From the CCC and blood (hematopoiesis, hemostasis): slight decrease in blood pressure (at low doses) or arterial hypertension, bradycardia.
From the gastrointestinal tract: dry mouth, nausea, gastrointestinal disorders, temporary increase in serum transaminase activity.
Interactions
Antihypertensive drugs, including diuretics, increase hypotension and bradycardia. Alcohol and sedatives deepen the depressive effect.
Overdose
Symptoms: nausea, vomiting, lowering blood pressure, dizziness, miosis, respiratory failure, coma.
Treatment: gastric lavage, activated charcoal, forced diuresis, maintenance of vital functions.
Dosage and administration
Inside. Dosing regimen should be selected individually. Tizanidine has a narrow therapeutic index and high variability in plasma levels of tizanidine in patients, so careful dose selection is required. Initial dose – 2-4 mg 3 times a day, in severe cases – an additional 2-4 mg at night. In case of neurologically caused spastic conditions, the initial dose should not exceed 6 mg per day in 3 doses with a gradual increase by 2-4 mg at intervals of 3-4 days – up to a week. The optimal therapeutic effect is usually achieved at a dose of 12-24 mg / day in 3-4 doses at regular intervals. Do not exceed a dose of 36 mg / day.
Precautions
Periodic monitoring of liver and kidney function is necessary and dose reduction if they worsen. A continuous increase in the activity of transaminases in the blood requires discontinuation. Due to possible drowsiness and weakness, it is recommended to limit the appointment to persons whose work requires a quick physical and mental reaction (operators, drivers of vehicles, etc.