Trazodone common side effects: Common and Rare Side Effects for trazodone oral

30.05.197927.11.2021 by alexxlab

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Trazodone vs. Ambien: Which one is better for you?

Trazodone and Ambien help people sleep. Trazodone is also used to treat symptoms of depression.

According to the American Sleep Association, insomnia is a common condition, affecting between 50 to 70 million people in the United States.

Trazodone and Ambien are two medications that are approved by the U.S. Food and Drug Administration (FDA). Both medicines are used to help people sleep. Trazodone is indicated for the treatment of depression, but is used off-label for insomnia. Trazodone causes a sedative effect of sleepiness and drowsiness, which is why many doctors prescribe it as a sleep aid for sleep problems.

Ambien is classified as a sedative-hypnotic and is thought to work by slowing down brain activity. Ambien helps you fall asleep. Ambien CR, an extended-release formulation, releases over time to help you fall asleep and stay asleep.

Although both medications are used for sleep, they have many differences. Continue reading to learn about trazodone and Ambien.

What are the main differences between trazodone and Ambien?

Trazodone is classified as an antidepressant. It is also known as an atypical antidepressant and serotonin modulator. Trazodone is a generic medication. The brand name of trazodone is Desyrel. However, Desyrel is no longer commercially available.

Ambien is classified as a sedative-hypnotic medication. It is a controlled substance. This means it is habit-forming and has the potential for abuse or dependence. It is available in both brand and generic form. Generally, women start at a lower dose of 5 mg. Men can start at 5 mg or a higher dose of 10 mg. Ambien should be taken immediately before bedtime.

Ambien is also available in an extended-release formulation, called Ambien CR. The generic name for Ambien is zolpidem. Ambien is indicated for short-term use; however, some people take Ambien for a more extended time under close supervision of the doctor.

Main differences between trazodone and Ambien
Drug class	Antidepressant (atypical antidepressant, serotonin modulator)	Sedative-hypnotic (also called benzodiazepine receptor agonist)
Brand/generic status	Generic	Brand and generic
What is the generic name? What is the brand name?	Brand: Desyrel	Generic: zolpidem
What form(s) does the drug come in?	Tablet	Ambien: tablet Ambien CR: tablet
What is the standard dosage?	For depression: The starting dose is 150 mg by mouth daily in divided doses. May increase by 50 mg per day every 3 to 4 days to a maximum of 400 mg per day in divided doses. Off-label for insomnia: The dose is usually 50 to 100 mg by mouth at bedtime.	Starting dose is 5 mg by mouth at bedtime for women, and 5 or 10 mg by mouth at bedtime for men. The medication should only be taken once at nighttime (it should not be taken again during the night), immediately before bed, with at least 7 to 8 hours to sleep. The maximum dosage is 10 mg at bedtime.
How long is the typical treatment?	Varies	Short-term, varies
Who typically uses the medication?	Adults	Adults

Conditions treated by trazodone and Ambien

Trazodone is indicated to treat major depressive disorder (depression) in adults. It is also used off-label for insomnia treatment.

Ambien is used to treat insomnia on a short-term basis. However, some people take Ambien for a longer time, under the close supervision of their doctor. Ambien CR is an extended-release formulation, and it is designed to release over time to help people fall and/or stay asleep.

Treatment of major depressive disorder in adults	Yes	No
Short-term treatment of insomnia	Off-label	Yes (Ambien)
Insomnia with difficulty falling and/or staying asleep	Off-label	Yes (Ambien CR)

Is trazodone or Ambien more effective?

One study looked at trazodone vs Ambien for insomnia. Both drugs were tolerated well with few side effects. Both trazodone and Ambien helped people in the study sleep better during the first week, but only Ambien helped people sleep better the second week. The study found Ambien to be more effective than trazodone.

The American Academy of Sleep Medicine Clinical guidelines recommend the following:

Trazodone: “We suggest that clinicians not use trazodone as a treatment for sleep onset or sleep maintenance insomnia (versus no treatment) in adults.”

Ambien: “We suggest that clinicians use zolpidem as a treatment for sleep onset and sleep maintenance insomnia (versus no treatment) in adults. ”

However, both recommendations are categorized as weak, which the American Academy of Sleep Medicine defines as a low level of certainty or appropriateness.

Therefore, because everyone is different, the most effective medication for a patient should only be determined by a doctor, who can consider the patient’s medical condition(s), history (including history of drug or alcohol abuse) and other medications they are taking that could interact with trazodone or Ambien.

You can also talk to your healthcare provider about other recommendations to help with sleep problems, including counseling and sleep hygiene.

Coverage and cost comparison of trazodone vs. Ambien

Most insurance and Medicare prescription plans cover trazodone. A typical prescription for 30, 100 mg tablets of trazodone would cost about $80 out-of-pocket, but if you use a free SingleCare card, you could pay as little as $4.

Most insurance and Medicare prescription plans cover generic Ambien, but they do not cover the brand-name product, or if they do, they charge a much higher copay. A typical prescription for 30, 10 mg tablets of generic Ambien costs about $55 if you pay out-of-pocket, but SingleCare coupon can lower the price to approximately $12.

As plans vary and are subject to change, contact your insurance provider for the most up-to-date insurance coverage information.

Typically covered by insurance?	Yes	Yes (generic)
Typically covered by Medicare Part D?	Yes	Yes (generic)
Quantity	30, 100 mg tablets	30, 10 mg tablets
Typical Medicare copay	$0-$20	$0-$20
SingleCare cost	$4+	$12+

Common side effects of trazodone vs. Ambien

The most common side effects of trazodone include blurred vision, dry mouth, dizziness/lightheadedness, drowsiness, and headache.

In short-term clinical trials, the most common side effects of Ambien included drowsiness, dizziness, and diarrhea. In people who took Ambien for 28 to 35 nights, the most common side effects were dizziness and a drugged feeling.

This is not a complete list of side effects. Other adverse effects may occur. Talk with your healthcare professional about what side effects to expect and how to address them.

Side effect	Applicable?	Frequency*	Applicable?	Frequency
Blurred or abnormal vision	Yes	6-15%	Yes	>1%
Constipation	Yes	7-8%	Yes	2%
Dry mouth	Yes	15-34%	Yes	3%
High blood pressure	Yes	1-20%	Yes	<1%
Low blood pressure	Yes	4-7%	Yes	<0.1%
Confusion	Yes	5-6%	Yes	>1%
Dizziness/lightheadedness	Yes	20-28%	Yes	1-5%
Drowsiness	Yes	24-41%	Yes	2-8%
Fatigue	Yes	6-11%	Yes	<1%
Headache	Yes	10-20%	Yes	7%
Nervousness	Yes	6-15%	Yes	<1%
Nausea/vomiting	Yes	10-13%	Yes	>1%
Diarrhea	Yes	0-5%	Yes	3%
Drugged feeling	No	–	Yes	3%

*trazodone data includes inpatient and outpatient groups

Source: DailyMed (trazodone), DailyMed (Ambien)

Drug interactions of trazodone vs.

Ambien

Trazodone should not be used within 14 days of an MAOI antidepressant. Trazodone should not be taken in combination with other drugs that increase serotonin due to the risk of serotonin syndrome. These drugs include other antidepressants, lithium, triptans, St. John’s Wort, opioids, dextromethorphan, and muscle relaxants. Do not take Ambien with other medicines that cause central nervous system (CNS) depression or other drugs that prolong the QT interval.

Because of its CNS depressant effects, do not take Ambien with other drugs with the same effect, such as opioids, benzodiazepines, antidepressants, or alcohol, due to additive effects. Ambien should not be taken with rifampin, because rifampin can decrease Ambien levels. Ambien should not be taken with ketoconazole (or the Ambien dose should be lowered), because ketoconazole can increase Ambien levels.

Avoid alcohol if you take trazodone or Ambien.

This is not a full list of drug interactions. Other, serious side effects may occur. See the Warnings section for more information. Consult your doctor for a full list of drug interactions.

Alcohol	Alcohol	Yes	Yes
Phenelzine Selegiline Tranylcypromine	MAOIs (monoamine oxidase inhibitors)	Yes	Yes
Rifampin	CYP3A4 inducer	Yes	Yes
Lithium	Bipolar disorder agent	Yes	No
Digoxin	Cardiac glycoside	Yes	No
Clopidogrel	Antiplatelet agent	Yes	No
Warfarin	Anticoagulant	Yes	No
Amiodarone Chlorpromazine Disopyramide Procainamide Quinidine Sotalol Thioridazine Ziprasidone	Drugs that prolong the QT interval	Yes	Some (chlorpromazine, thioridazine, ziprasidone)
Itraconazole Ketoconazole	CYP3A4 inhibitor	Yes	Yes
St. John’s Wort	Supplement	Yes	Yes
Alprazolam Clonazepam Diazepam Lorazepam	Benzodiazepines	Yes	Yes
Codeine Fentanyl Hydrocodone Hydromorphone Methadone Morphine Oxycodone Tramadol	Opioids	Yes	Yes
Clarithromycin Erythromycin	Macrolide antibiotics	Yes	Yes (clarithromycin)
Citalopram Escitalopram Fluoxetine Fluvoxamine Paroxetine Sertraline	SSRI antidepressants	Yes	Yes
Desvenlafaxine Duloxetine Venlafaxine	SNRI antidepressants	Yes	Yes
Amitriptyline Desipramine Imipramine </span Nortriptyline	Tricyclic antidepressants	Yes	Yes
Baclofen Carisoprodol Cyclobenzaprine Metaxalone	Muscle relaxants	Yes	Yes
Carbamazepine Divalproex sodium Gabapentin Lamotrigine Levetiracetam Phenobarbital Phenytoin Pregabalin Topiramate	Anticonvulsants	Yes	Yes
Diphenhydramine	Sedating antihistamine	Yes	Yes

Warnings of trazodone and Ambien

Before taking trazodone or Ambien, talk to your doctor about all of the medical conditions you have and all of the medications you take, including prescription drugs, over-the-counter (OTC) medications, and vitamins or supplements. When you fill or refill your trazodone or Ambien prescription, you will receive a Medication Guide that discusses warnings, side effects, and other important information. Read the Medication Guide every time you fill your prescription.

Trazodone

Trazodone has a black box warning, or boxed warning, which is the most serious warning required by the FDA. All antidepressants, including trazodone, can increase the risk for suicidal thoughts and behavior. The risk is higher in children, adolescents, and young adults. Anyone who takes trazodone should be closely monitored for mood changes and suicidal thoughts and behavior. Trazodone is not approved for use in children.

Other trazodone warnings:

Do not use an MAOI (monoamine oxidase inhibitor) drug within 14 days of using trazodone.
There is an increased risk of serotonin syndrome when trazodone is taken with other drugs that increase serotonin. These drugs include other antidepressants, triptans, opioid pain relievers, muscle relaxants, dextromethorphan (found in prescription and OTC cough and cold medications), tryptophan, and St. John’s Wort.
Using aspirins, NSAIDs, antiplatelet drugs, or warfarin can increase the risk of bleeding.
Trazodone increases the QT interval. Do not take trazodone if you take other drugs that increase the QT interval or if you have risk factors for prolonged QT interval.
Low blood pressure and fainting may occur, especially when going from a sitting or lying position to standing up.
Priapism may occur. Priapism is a painful and prolonged erection. Seek immediate medical attention if this happens.
Before using trazodone, patients should be screened for bipolar disorder (including family history).
Trazodone can impair judgment, thinking, and motor skills. Do not drive or operate machinery until you know how trazodone affects you.
Do not drink alcohol while taking trazodone.
Trazodone can cause withdrawal symptoms if you stop taking it too quickly. Do not stop taking trazodone unless your doctor instructs you to do so and provides you with a tapering schedule.
Use caution in patients with angle-closure glaucoma.

Ambien

Ambien also has a boxed warning. Ambien may cause complex sleep behaviors. These behaviors include sleep-walking, sleep-driving, cooking, eating, having sex, or other activities performed while not fully awake after using Ambien. Some of these events can be dangerous and result in death. If you experience a complex sleep behavior, stop taking Ambien and consult your doctor. Ambien is not approved for use in children.

Other Ambien warnings:

Ambien is a central nervous system depressant (CNS depressant). Do not take Ambien with other CNS depressants such as alcohol, benzodiazepines (like Valium or Xanax), or opioids.
Take Ambien when you have at least seven or eight hours to sleep. Take Ambien immediately before bedtime. For example, if you take a shower and brush your teeth before bed, take Ambien after you do these things, just before bedtime. Ambien can cause impairment on the next day as well. Symptoms can include drowsiness, prolonged reaction time, dizziness, vision disturbances, reduced alertness, and impaired driving. Do not drive (or perform other activities that require mental alertness) the next day unless you have slept at least seven or eight hours after taking Ambien and are alert.
Ambien can cause drowsiness and a decreased level of consciousness. People who take Ambien, especially older adults, have an increased risk of falls.
If insomnia does not improve after seven to 10 days of treatment, another illness may be causing insomnia. Insomnia treatment should start only after careful examination of the patient.
Severe allergic reactions are rare. If you take Ambien and have nausea, vomiting, throat closing, shortness of breath, or swelling of the tongue or throat, seek emergency medical treatment.
Ambien may cause abnormal thinking and behavior changes, including low inhibition, aggressiveness, agitation, and hallucinations.
In people who have depression, taking Ambien can lead to worsened depression and suicidal thoughts and behavior. The lowest dose for the shortest amount of time should be prescribed.
Use caution prescribing Ambien in people with breathing problems such as sleep apnea or myasthenia gravis.
Avoid Ambien in people with severe liver problems.
Withdrawal symptoms may occur when Ambien is stopped abruptly. If you want to stop taking Ambien, consult your healthcare provider for guidance and a tapering schedule.
With Ambien CR, swallow whole. Do not chew, crush, or break tablets.

Frequently asked questions about trazodone vs. Ambien

What is trazodone?

Trazodone is an antidepressant drug that treats major depressive disorder in adults. It is also used off-label to treat insomnia in adults.

What is Ambien?

Ambien is a sedative-hypnotic medication that treats insomnia. It is a controlled substance due to the potential for abuse or dependence.

Are trazodone and Ambien the same?

Trazodone and Ambien are commonly used to treat insomnia. Trazdone is approved to treat depression, but is used off-label for insomnia. Ambien is indicated for insomnia treatment. However, the two drugs are not the same. They are in different drug categories and have other differences, as described above.

Is trazodone or Ambien better?

Studies suggest that Ambien may be more effective than trazodone. However, Ambien is a controlled substance and has the potential for abuse and dependence. Your doctor can look at your medical history and other factors to determine if one of these drugs is appropriate for you.

Can I use trazodone or Ambien while pregnant?

If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider for medical advice.

Using trazodone late in pregnancy may cause withdrawal symptoms in the baby, including breathing problems, jitteriness, and difficulty feeding. Using Ambien in late pregnancy can cause similar symptoms. Ambien can also cause respiratory depression and sedation in newborns.

Can I use trazodone or Ambien with alcohol?

Trazodone should not be combined with alcohol. Trazodone may worsen the effects of alcohol, such as dizziness, sedation, and motor impairment. The combination can also cause respiratory depression (slowed breathing which could lead to a coma or death) and increase the risk for trazodone overdose.

Ambien and alcohol should not be combined. The combination can cause excess sedation and motor impairment, as well as respiratory depression. Also, if you have a history of drug or alcohol abuse, Ambien may not be appropriate for you because of its potential for abuse and dependence.

trazodone | Cigna

What should I discuss with my healthcare provider before taking trazodone?

You should not use trazodone if you are allergic to it.

Do not use trazodone if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, tranylcypromine, and others.

After you stop taking trazodone, you must wait at least 14 days before you start taking an MAOI.

Tell your doctor if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson’s disease, migraine headaches, serious infections, or prevention of nausea and vomiting. An interaction with trazodone could cause a serious condition called serotonin syndrome.

Tell your doctor if you have ever had:

liver or kidney disease;
heart disease, or a recent heart attack;
a bleeding or blood clotting disorder;
seizures or epilepsy;
narrow-angle glaucoma;
long QT syndrome;
drug addiction or suicidal thoughts; or
bipolar disorder (manic depression).

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Taking this medicine during pregnancy could harm the baby, but stopping the medicine may not be safe for you. Do not start or stop trazodone without asking your doctor.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of trazodone on the baby.

Ask a doctor if it is safe to breastfeed while using this medicine.

Trazodone is not approved for use by anyone younger than 18 years old.

Trazodone: Dosage, Uses, And Side Effects

If you have any medical questions or concerns, please talk to your healthcare provider. The articles on Health Guide are underpinned by peer-reviewed research and information drawn from medical societies and governmental agencies. However, they are not a substitute for professional medical advice, diagnosis, or treatment.

If you research antidepressants, you’ll find that there are many options. One of the oldest antidepressants is trazodone, which has been around since the 1980s. Read on to learn more about trazodone, including its potential uses, side effects, drug interactions, and more.

Trazodone is a prescription antidepressant medication that has been used for decades. It is available as a generic drug but has also been sold under several brand names worldwide, including Desyrel and Oleptro.

Like many other types of antidepressant medications, trazodone affects certain natural substances in the brain called neurotransmitters. Trazodone belongs to a class of antidepressants called serotonin antagonist and reuptake inhibitors (SARIs). It works mainly by increasing the levels of serotonin between nerve cells. Serotonin is a neurotransmitter necessary that helps facilitate communication between nerves.

Antidepressants: types, side effects, uses, and risks

Scientists don’t understand the exact mechanisms of how trazodone works. Some of its effects may be because trazodone also blocks certain other serotonin reuptake transporters and receptors, further affecting brain chemistry (Shin, 2021).

Trazodone is FDA-approved to treat major depressive disorder (MDD).

According to the National Institute of Mental Health (NIMH), major depressive disorder (often simply called depression) is one of the most common mental health disorders in the U.S. It is more than just “feeling sad” or “blue”—depression is a mood disorder that can affect all aspects of your life, like eating, sleeping, working, relationships, social life, etc. (NIMH, 2018).

Trazodone may improve your depression symptoms and help you start feeling like yourself again.

Sometimes, healthcare providers use trazodone “off-label”—this means that the FDA hasn’t approved trazodone for that specific purpose.

One of the most common off-label uses of trazodone is for treating insomnia. Everyone has had trouble sleeping because of one reason or another—work stress, relationship issues, trauma, etc. But this usually goes back to normal after a few days or weeks. Chronic insomnia lasts for a month or more and is often caused by some other problems. Common causes of sleep problems include caffeine or alcohol use, medications, medical conditions, or other sleep disorders.

You can imagine that a month of not sleeping well can wreak havoc on your body and your life. Trazodone is sometimes prescribed to help you get your sleep schedule back on track.

Other examples of off-label uses for trazodone include (Shin, 2021):

Insomnia: what is it, symptoms, causes, treatments

Sleep

Jun 08, 2021

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Like all medications, trazodone may cause side effects in some people. Common side effects of trazodone include (UpToDate, n.d.):

Dry mouth
Dizziness/lightheadedness
Nausea/vomiting
Sleepiness/decreased alertness
Fatigue or tiredness
Headache
Nervousness
Blurred vision

Less frequently, people experience severe side effects like (UptoDate, n. d.):

Increased thoughts of suicide, especially in younger people
Serotonin syndrome: Too much serotonin in the body can lead to agitation, hallucinations, increased body temperature, high blood pressure and heart rate, muscle tremors, vomiting, diarrhea, etc.
Abnormal heart rhythms (arrhythmias)
A sudden drop in blood pressure when you stand from a sitting position (orthostatic hypotension)
Increased risk of bleeding, especially if you are taking blood thinners
Priapism (a painful erection that lasts 4–6 hours or longer)

If you do experience side effects, do not stop trazodone suddenly. Going cold turkey can lead to discontinuation syndrome and withdrawal symptoms. Talk to your healthcare provider about discontinuing the drug slowly over time.

This list does not include all possible side effects and others may occur. Seek medical advice from your pharmacist or healthcare provider for more information.

Trazodone hydrochloride tablets are available in 50 mg, 100 mg, 150 mg, and 300 mg strengths. Your healthcare provider will adjust your dose based on your condition and how well the medication is working.

Inform your healthcare provider about any other drugs you may be taking before starting trazodone, including over-the-counter medications and herbal supplements. Potential drug interactions include (FDA, 2017):

Monoamine oxidase inhibitors (MAOIs): You should not use trazodone within 14 days of taking MAOIs like phenelzine, tranylcypromine, linezolid, isocarboxazid, methylene blue, and selegiline. Both trazodone and MAO inhibitors increase serotonin levels, and using them together increases your risk of serotonin syndrome.
Drugs that increase serotonin levels (serotonergic drugs): Many medications can increase serotonin levels. Combining them with trazodone can raise the likelihood of developing serotonin syndrome. Examples of medicines that should not be taken with trazodone include tricyclic antidepressants, selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), and St. John’s wort.
Blood thinners: Trazodone can interfere with the clotting process, increasing the likelihood of bleeding. This risk is even higher when combined with blood thinners (anticoagulants). Your healthcare provider may need to adjust your trazodone dose.
Drugs that affect the CYP3A4 system: The CYP3A4 system of the liver breaks down trazodone. Medicines that block this system prevent trazodone from being metabolized, and more of the drug than expected ends up in your system. This can increase your risk of side effects. Alternatively, medications that increase the activity of the CYP3A4 system cause trazodone to be broken down faster than expected, making your dose less effective. If you take any medications that affect the CYP3A4 system, your healthcare provider may adjust your trazodone dose.
Digoxin and phenytoin: Trazodone can increase the levels of digoxin or phenytoin.
Drugs that cause QT prolongation: Certain medications affect your heart rhythm by lengthening the QT interval, a part of the electrical process in the heart. Combining these types of drugs with trazodone raises the risk of developing abnormal heart rhythms or arrhythmias.
CNS depressants: Drugs that slow down the central nervous system (CNS) should not be combined with trazodone because it enhances the effects (and potential toxicity) of the CNS depressants. Examples include alcohol and sleeping pills.

SSRIs: everything you need to know

This list does not include all possible drug interactions with trazodone and others may occur. Talk to your pharmacist or healthcare provider for more information.

There is a black box warning from the U.S. Food and Drug Administration (FDA) on all antidepressants, including trazodone. These drugs have an increased risk of suicidal thoughts and behaviors in children, teenagers, and young adults. Families and caregivers should be aware of this risk, especially during the first few months of therapy or after a dose increase. Be on the lookout for suicidal thoughts, attempts, or other mood changes. Trazodone is not FDA-approved for use in people under 18 years of age (FDA, 2017).

Certain groups of people are at higher risk of adverse effects with trazodone and should avoid using it or use it with caution and careful monitoring. Examples of these groups include (UptoDate, n.d.):

Pregnant or nursing women: According to the FDA, trazodone is Pregnancy Category C, meaning there is not enough data to say whether or not trazodone is safe during pregnancy (FDA, 2017). Also, research shows that trazodone enters breast milk. However, when deciding whether or not trazodone is the proper treatment while nursing, you and your healthcare provider should consider both the potential risks to the baby and the benefits to the mother.
Older adults: People over 65 may be at a higher risk of developing low sodium (hyponatremia) while taking trazodone.
People with bipolar disorder: Trazodone can trigger a manic or hypomanic episode in people with bipolar disorder. Trazodone is not FDA-approved to treat bipolar disorder and should be avoided in this group.
People who have or who are at risk for angle-closure glaucoma: Trazodone may trigger an episode of angle-closure glaucoma (high eye pressure, eye pain, eye redness, blurred vision, halos around lights) that can lead to permanent vision loss. Angle-closure glaucoma usually only occurs in people with “narrow angles in the eye”—meaning that the front part of the eye is shallower than average. Your healthcare provider may recommend an eye exam before starting trazodone.
People with liver or kidney disease: These groups may develop higher than desired levels of trazodone and may need to adjust their dose.
People with a severe allergic reaction to trazodone (e.g., rash, itching, hives, trouble breathing, etc.) should not take trazodone.

This list does not include all at-risk groups. Talk to your healthcare provider or pharmacist for more information.

Trazodone tablets

What is this medicine?

TRAZODONE (TRAZ oh done) is used to treat depression.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Desyrel

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

attempted suicide or thinking about it
bipolar disorder
bleeding problems
glaucoma
heart disease, or previous heart attack
irregular heart beat
kidney or liver disease
low levels of sodium in the blood
an unusual or allergic reaction to trazodone, other medicines, foods, dyes or preservatives
pregnant or trying to get pregnant
breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take this medicine shortly after a meal or a light snack. Take your medicine at regular intervals. Do not take your medicine more often than directed. Do not stop taking this medicine suddenly except upon the advice of your doctor. Stopping this medicine too quickly may cause serious side effects or your condition may worsen.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:

certain medicines for fungal infections like fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole
cisapride
dronedarone
linezolid
MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
mesoridazine
methylene blue (injected into a vein)
pimozide
saquinavir
thioridazine

This medicine may also interact with the following medications:

alcohol
antiviral medicines for HIV or AIDS
aspirin and aspirin-like medicines
barbiturates like phenobarbital
certain medicines for blood pressure, heart disease, irregular heart beat
certain medicines for depression, anxiety, or psychotic disturbances
certain medicines for migraine headache like almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan
certain medicines for seizures like carbamazepine and phenytoin
certain medicines for sleep
certain medicines that treat or prevent blood clots like dalteparin, enoxaparin, warfarin
digoxin
fentanyl
lithium
NSAIDS, medicines for pain and inflammation, like ibuprofen or naproxen
other medicines that prolong the QT interval (cause an abnormal heart rhythm) like dofetilide
rasagiline
supplements like St. John’s wort, kava kava, valerian
tramadol
tryptophan

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Tell your doctor if your symptoms do not get better or if they get worse. Visit your doctor or health care professional for regular checks on your progress. Because it may take several weeks to see the full effects of this medicine, it is important to continue your treatment as prescribed by your doctor.

Patients and their families should watch out for new or worsening thoughts of suicide or depression. Also watch out for sudden changes in feelings such as feeling anxious, agitated, panicky, irritable, hostile, aggressive, impulsive, severely restless, overly excited and hyperactive, or not being able to sleep. If this happens, especially at the beginning of treatment or after a change in dose, call your health care professional.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

This medicine may cause dry eyes and blurred vision. If you wear contact lenses you may feel some discomfort. Lubricating drops may help. See your eye doctor if the problem does not go away or is severe.

Your mouth may get dry. Chewing sugarless gum, sucking hard candy and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
elevated mood, decreased need for sleep, racing thoughts, impulsive behavior
confusion
fast, irregular heartbeat
feeling faint or lightheaded, falls
feeling agitated, angry, or irritable
loss of balance or coordination
painful or prolonged erections
restlessness, pacing, inability to keep still
suicidal thoughts or other mood changes
tremors
trouble sleeping
seizures
unusual bleeding or bruising

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

change in sex drive or performance
change in appetite or weight
constipation
headache
muscle aches or pains
nausea

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 to 86 degrees F). Protect from light. Keep container tightly closed. Throw away any unused medicine after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Top 12 Facts about Trazodone

1. What is trazodone?

Trazodone is an antidepressant drug. While the primary mechanism of action of this drug is not yet fully ascertained, it is believed to affect the brain’s neurotransmitters specifically by inhibiting the reuptake or reabsorption of serotonin by the nerves in the brain. When this happens, it could decrease depression symptoms as well as elevate the mood, increase appetite, and negate anxiety symptoms.

2. Primary used for depression treatment

Trazodone is primarily used for treating major depression which is considered as a medical illness that can be treated. Major depression is characterized by a period of deep sadness, low motivation levels, and irritability lasting for at least 14 days in a row. The person’s depression is so severe that it already affects day-to-day activities and the person is unable to function normally. According to different studies, a chemical imbalance in the brain is said to be one of the causes of depression. This is the reason why medications such as trazodone is recommended to people in order to modulate these brain chemicals.

3. Trazodone for sleep disorders

Another common use for trazodone is to treat sleep disorders like insomnia. The reason for this is because after taking trazodone, a common side effect is to feel drowsy. This is the reason why there are many people who use trazodone as a sleeping pill substitute. When people in recovery are undergoing insomnia as a part of their withdrawal symptoms, trazodone may also be prescribed to these people. It is however important to note that using this drug as a sleep aid is not an FDA-approved application. The number of studies on whether this drug is certainly effective for insomnia and safe for use is also very limited.

4. Trazodone for schizophrenia and anxiety

Aside from treating depression and sleep problems, trazodone is also given as treatment to patients suffering from schizophrenia and anxiety disorder. trazodone does not cure these two disorders, rather, the drug only helps manage the underlying symptoms.

5. Trazodone and Xanax

Because it is prescribed to treat anxiety, trazodone is often compared to the antianxiety drug Xanax. One popular question is whether trazodone is like Xanax and if it is as effective. Trazodone and Xanax are very different in their chemical structure and their mechanisms of action in the body. However, trazodone also became popular with people who are using Xanax as a recreational drug, thinking that trazodone will provide the same effects.

6. How long does it take effect?

The effect of trazodone will depend on what you use it for. If you are using it for sleep or anxiety, you may be able to feel the drowsiness effects in one to three hours. However, if you are using it to treat your depression, it may take 1 to 2 weeks before you feel any effect and you many need up to 6 weeks before you actually gain the full benefit of the drug.

7. Side effects

Aside from feeling drowsy, some of the common side effects of trazodone include muscle pain, constipation, dry mouth or foul taste in the mouth, headaches, weakness, and intense nightmares. There are people who also experience itching, hives, swelling, sweating, nausea, diarrhea, numbness, drop in blood pressure, ringing in the ears, abnormal bruising or bleeding, and dizziness.

8. Sexual effects

Another known side effect of trazodone is priapism. This condition is characterized by a prolonged and painful penile erection in men, usually lasting four hours, even if they’re not engaging in sexual activity. While this may seem like a good thing that the drug is giving off Viagra-like symptoms, priapism can result in permanent erectile dysfunction in case it is not properly attended medically. There are also some people who reported that they experienced decreased sexual drive while taking the drug.

9. Warnings

People who are suffering a heart condition as well as older people should be cautious about taking the drug. It is also not recommended for people with low levels of magnesium and potassium in their blood. Before using trazodone, you should take into account what other drugs and substances you are taking as it has contraindications with various drugs.

10. Suicide and Trazodone

While this drug might help in treating major depression, a risk associated with taking it is suicide. This is because antidepressants have been shown to increase the risk of suicidal tendencies for young adults and children. If you have experienced suicidal thoughts and have engaged in suicidal behaviors before, it is safer to inform your doctor and not take this drug. If you are a first-time user of this drug, avoid self-medicating. Being in the supervision of a doctor is very important to monitor your behavior.

11. Is trazodone addictive?

Unlike opioids and benzodiazepines like Xanax, trazodone is not believed to be addictive. This does not, however, mean that trazodone addiction does not exist. Because it provides sedative effects, there are now people who are misusing trazodone for recreational purposes or as a daily sleep aid. Just like any other drug, persistent use of this drug can lead to tolerance, which can cause people to take higher doses and become addicted. Once people stop using the drug, it can also cause withdrawal symptoms.

12. Trazodone addiction treatment

Trazodone is a prescription drug that should only be used as indicated by a medical professional. Using it for other purposes can lead to addiction and even overdose. For people who are addicted to trazodone, recovery is possible. There are specialized treatment options that can help.

If you are struggling with substance abuse issues, contact Anaheim Lighthouse today.

Is Trazodone Addictive? (Abuse, Overdose & Treatment)

What is Trazodone?

Trazodone is a generic antidepressant prescription medication that is used to treat major depressive disorder and other mood disorders, including anxiety and post-traumatic stress disorder (PTSD).

Desyrel and Oleptro are two brand names for trazodone.

Is Trazodone Addictive?

According to the U.S. Drug Enforcement Administration (DEA), trazodone does not have any risk for drug abuse or drug addiction. However, with regular use some people develop a mild physical dependence that becomes apparent when they stop taking the drug.

What is Trazodone Used For?

Trazodone is an ‘atypical antidepressant’ that affects the brain differently than more common antidepressants. Trazodone belongs to a class of drugs called selective serotonin re-uptake inhibitors (SSRIs), which are antidepressant medications block serotonin signaling in specific receptors in the brain.

The overall effect of trazodone is to reduce activity in parts of the brain that cause depression and anxiety.

Trazodone manages symptoms associated with:

Depression
Anxiety disorders

It’s sedative effects have also proven to be helpful in treating people with:

Insomnia
Eating disorders
Substance use disorders
Some pain conditions

In fact, trazodone is the most commonly prescribed (off-label) sleep aid to treat insomnia and trouble sleeping, although it is not FDA-approved to treat sleep disorders. Additionally, one study found that trazodone is a more effective anti-anxiety medication than the popular (and powerfully addictive) prescription drug diazepam, which is sold under the brand name Valium.

Medical researchers are currently evaluating whether trazodone can help people with neurodegenerative disorders like muscular sclerosis (MS), Alzheimer’s Disease, and Parkinson’s Disease.

A 2019 pilot study in humans with Alzheimer’s Disease found that trazodone reduced symptoms of dementia and slowed cognitive decline.

Risks of Trazodone

Trazodone is not associated with a risk for abuse or addiction, but there are some risks that people should be aware of before they take the drug.

Suicidal Thoughts

The most serious risk associated with trazodone use is an increased risk for suicidal thoughts or actions, particularly among teenagers and young adults (24 years and younger). The risk for suicide is lower among people taking trazodone it is for people with untreated depression, but it is important to be aware of signs of suicidal ideation, especially in the first few months of taking it.

Suicidal thoughts or actions are the most dangerous risk associated with taking trazodone, and young adults are the most likely to be affected.
U.S. Food and Drug Administration

Serotonin Syndrome

Serotonin syndrome is a potentially life-threatening condition that is caused by excess serotonin levels in the brain. Taking too much trazodone or combining it with other drugs that inhibit serotonin reuptake increases the risk that someone will experience serotonin syndrome.

Many people take the over-the-counter herbal drug St. John’s Wort, which eases depression symptoms by modestly increasing serotonin levels. People who take trazodone or another antidepressant should never take St. John’s Wort.

If you are given a prescription for an antidepressant, make sure to tell your doctor about any other prescription, over-the-counter, or illegal drugs that you use.

Antidepressant Discontinuation Syndrome

About 20 percent of people who quit taking trazodone abruptly will experience antidepressant discontinuation syndrome.

Symptoms of this include:

sensory disturbances (vertigo, lightheadedness)
altered sleep patterns
headache
anxiety
dizziness

Side Effects of Trazodone

Trazodone works by interrupting serotonin signaling, which has several physiological consequences. Serotonin is widely understood to be the ‘depression’ neurotransmitter, but it has important roles in other regulatory systems in the body, including maintaining body temperature, regulationing the gastrointestinal system, and maintaining cardiovascular function. Thus, trazodone use is often associated with several side effects that are unrelated to mood.

Common side effects of trazodone use include:

Sedation
Drowsiness
Dry mouth
Headache
Nausea/vomiting
Diarrhea

Low blood pressure (hypotension)
Dizziness
Muscle aches
Blurred vision
Constipation

Trazadone may also cause more serious side effects. Severe side effects include chest pain, shortness of breath, difficulty breathing, sexual dysfunction, and fast or irregular heart rate or heart rhythm.

Trazodone Overdose

Trazodone overdoses are not common, but it is possible. The risk for overdose is multiplied if trazodone is mixed with other substances, especially other CNS depressants.

Symptoms of trazodone overdose include:

Chest pain
Irregular heartbeat
Decreased heart rate
Low blood pressure
Difficulty breathing or respiratory arrest
Dizziness and lack of coordination
Drowsiness

Headache
Nausea
Vomiting
Seizures
Tremors
Coma

Trazodone overdose can also lead to more serious side effects. These include:

Serotonin syndrome
Priapism (a painful erection that lasts for more than 4 hours)
Cardiac conduction abnormalities (potentially deadly disorders of the electrical system that controls your heart rate and rhytm)
Severe hypotension (low blood pressure)

Trazodone Interactions

Anytime you take a new drug, speak with your pharmacist about any possible interactions. You should disclose all of your medical history and any other medications you are currently or recently stopped taking.

Specifically, tell your doctor if you or your family has any history of:

Bipolar disorder
Liver disease
Heart disease
Heart attacks
Suicide attempts

In addition to these health conditions, trazodone interacts with hundreds of other drugs.

Common interactions include, but are not limited to:

MAO Inhibitors including methylene blue, isocarboxazid, selegiline, linezolid, moclobemide, tranylcypromine, procarbazine, rasagiline, safinamide, phenelzine, etc.
Antifungals such as itrazonazole and ketoconazole
HIV protease inhibitors like ritonavir and indinavir
Macrolide antibiotics such as erythromycin
Seizure medications including phenytoin
Rifamycins such as rifampin
Drugs that increase serotonin like St. John’s wort, MDMA/ecstasy, certain antidepressants including SSRIs and SNRIs
Drugs that cause drowsiness such as alcohol, marijuana, antihistamines, sleeping pills, anxiety medication, muscle relaxants, and opioid pain relievers

This is not a complete list of trazodone interactions. Speak with your doctor and share all current, recent, and future medications with them (including prescription, over-the-counter, and herbal supplements) to avoid adverse reactions.

Trazodone Abuse & Addiction Symptoms

Since there is little to no risk for trazodone addiction, there are no addiction symptoms. The definition of addiction is having obsessive drug-seeking behavior in the face of adverse health and/or social consequences, and even long-term trazodone use does not lead to addictive behavior.

There is a risk for developing a mild physical dependence on trazodone. Although it’s not common, some people who suddenly stop taking the drug will experience uncomfortable symptoms associated with antidepressant discontinuation syndrome.

Addiction Treatment

Trazodone is not addictive, but around 20 percent of people who stop taking the drug will experience antidepressant discontinuation syndrome, which is similar to acute withdrawal symptoms.

This syndrome is not well understood, and it does not affect everyone who quits taking antidepressants. For the people who are affected, symptoms can be very uncomfortable and disorienting. People who have taken trazodone for a long time are more likely to experience discontinuation syndrome.

Around 20 percent of people who stop taking trazodone will experience symptoms of antidepressant discontinuation syndrome, including lightheadedness and insomnia.
American Family Physician

The best way to prevent or minimize symptoms of discontinuation syndrome is to work with a doctor to develop a dosing schedule that progressively declines over time. By gradually reducing the dose over a period of several days or weeks, the brain becomes accustomed to functioning without trazodone.

Symptoms of antidepressant discontinuation syndrome typically last for a few days, but in rare cases people may experience prolonged symptoms that persist for two to three weeks.

One trazodone-related event that requires medical treatment is serotonin syndrome. Serotonin syndrome is caused by too much serotonin in the brain.

Symptoms of serotonin syndrome include:

Tremor
Muscle rigidity
Excessive sweating
Vomiting
Diarrhea
Agitation

In extreme cases, hallucinations and seizures may be present. Serotonin syndrome can be fatal and requires immediate medical treatment.

Summary

Trazodone is a commonly prescribed atypical antidepressant that is generally well-tolerated and is not addictive. However, people who quit taking trazodone abruptly or detox, may experience uncomfortable symptoms as a result of antidepressant discontinuation syndrome.

Depression is not the only condition that trazodone improves.

Doctors often prescribe it to help people sleep better, manage stress and anxiety, and reduce pain. Clinical trials are currently being conducted to determine whether prescribing trazodone can help people with neuropathic pain and sleep apnea, and enhance memory in people with depression.

Trazodone Addiction – Transformations Treatment Center

Trazodone is an antidepressant used in the treatment of depression, anxiety and insomnia. It is the most popular member of a class of medications called serotonin antagonist and reuptake inhibitors, or SARIs. Its effectiveness as an antidepressant is comparable to other medications in different antidepressant classes. Such as the selective serotonin reuptake inhibitor Prozac or the selective norepinephrine reuptake inhibitor Cymbalta.

Despite its identity and effectiveness as an antidepressant, you are probably more familiar with trazodone as a medication to treat insomnia. With 26 million prescriptions filled in 2014 alone.¹ It is the most commonly prescribed insomnia medication. As well as the second most common overall behind diphenhydramine. Which is available over-the-counter in several types of preparations. Due to its unique effects on the body’s serotonin regulation system, the dosage of trazodone required to treat insomnia is much lower than the dose required to treat depression.

Common Side Effects of Trazodone

Trazodone has two particularly common side effects: sedation and orthostatic hypotension. Which is the inability of the body to maintain adequate blood pressure when changing positions. It is also infamous for the rare, but alarming, side effect of priapism. The presence of a penile erection lasting for several hours despite the lack of sexual arousal. Nevertheless, it is considered a safer alternative to benzodiazepines or other medications from the sedative/hypnotic class. Those other medications are known to be habit-forming, and tolerance to them builds after just a few weeks of use.

Trazodone is not generally habit-forming. It does not produce euphoria and does not create physical dependence. However, its sedative effect can lead to misuse. For some, trazodone’s sleep-inducing effect helps them avoid undesirable responsibilities. For others, trazodone is useful in reducing unwanted stimulant effects from other drugs.

Overdoses of trazodone do occur, though they are usually not fatal if trazodone is the only drug involved. When combined in overdose with central nervous system depressants, the fatality rate is considerably higher. Cardiac arrhythmias, or disturbances to the heart’s normal beating pattern, and severely low blood pressure are significant potential outcomes of a trazodone overdose.

Have you been prescribed trazodone? What does your relationship with it look like? Transformations Treatment Center can help you better understand your connection to your medication. Additionally we offer healthy alternatives if that connection has been harmful.

Need More Information?

Call now to be connected with one of our friendly, helpful admissions specialists.

How Trazodone Works Within Your Body

Like many antidepressants, the primary target for the action of trazodone is serotonin. Which is a nerve cell messenger widely distributed throughout your body. Serotonin in the brain is, among other functions, responsible for the regulation of mood and anxiety levels. And your body has many different control levers for it. Trazodone blocks nerve cell receptors from binding up serotonin using a few of these levers. Trazodone also blocks nerve cells from absorbing serotonin out of the area that two or more nerve cells use to communicate. The effect is to create higher levels of serotonin for nerve cell communication. Which in turn leads to better mood and reduced anxiety. This effect, combined with trazodone’s mild antihistamine effect and reversal of the “fight-or-flight” response system, is why trazodone is so effective at treating insomnia.

How to Identify Problematic Trazodone Use

While problematic trazodone usage does not produce many physical signs and symptoms, certain indicators are helpful for you or your family and friends to identify it.Taking more trazodone than what is prescribed, without your provider’s permission, strongly suggests problem use. Similarly, non-prescribed ingestion of a medication like trazodone points to problem use. The refusal or inability to stop taking trazodone despite suffering negative consequences from its use is a clear indicator that a problem is present; this is a hallmark symptom of addiction, no matter the substance.

Other signs and symptoms of trazodone misuse might include:

Visible over-sedation
Unsuccessful attempts to cut down usage
Taking trazodone with alcohol or other drugs

How to Treat Trazodone Misuse

Many antidepressants, including trazodone, are thought to remodel the brain’s serotonin regulation system. In these cases, it is often best to begin treatment with medical detoxification to avoid withdrawal symptoms from abruptly removing medications that act on serotonin. Especially in cases where more trazodone is being taken than prescribed, it will be important to monitor vital signs and to safely taper off of the medication.

When the problematic use of trazodone is identified, the main choice of psychotherapy is cognitive behavioral therapy (CBT). The primary goal of CBT is to show you how to change unhealthy behaviors by re-examining and challenging the thought processes that lead to them. CBT is a mainstay of the treatment of addictive disorders, and a specialized form of it has been adapted and utilized to treat insomnia without the use of medications. Participation in a 12-step program will ensure that you receive support, develop new skills and establish accountability with others. Motivational interviewing may also be used in treatment.

At Transformations Treatment Center, we will help you face the problematic use of trazodone in a nonjudgmental, non-confrontational way. Our professional staff is highly trained in the best evidence-based practice, and we will create a comprehensive program to meet your specific needs. Contact us today to discuss your options for treatment.

90,000 Trazodone addiction | What you need to know about trazodone addiction

Side effects and risks of trazodone

Trazodone may cause side effects in people who take it. The good news for users is that the side effects of trazodone are not life threatening or long lasting. However, the side effects of trazodone can be serious enough to be needed by a healthcare professional. The most common side effects of trazodone are:

Blurred vision
Drowsiness, drowsiness, dizziness, or fatigue
sweating
Body and / or face edema
Weight loss without diet
Blocked nose 9000 Other

for taking trazodone, but they are less common.Less likely side effects include:

Dry mouth and throat
Constipation or diarrhea
Sexual dysfunction
Painful and persistent penile or clitoris erection
Heart arrhythmias

There are some serious side effects that can occur with trazodone in people. If any of these problems occur, patients should seek immediate medical attention. These side effects include:

Rash / urticaria
Rapid heartbeat
Shortness of breath
Sudden dizziness
Feel like fainting
Decreased heart rate

Easy to get 9000 blue sodium

Can a person overdose on trazodone?
Users can overdose on trazodone if the medication is not taken as directed.Taking too much trazodone can lead to serotonin syndrome. This happens when serotonin builds up in the body. Signs of serotonin syndrome include:
- Agitation / anxiety
- Restlessness
- Muscle twitching
- Confusion
- Raised heart rate / high blood pressure
- Upset stomach
- Cold / chills / shivering / shivering on the skin
Patients with the following symptoms should seek medical attention:
- Fever
- Convulsions / convulsions
- Arrhythmia
- Coma Unconsciousness /
Overdose of trazodone can be life-threatening.The medicine should not be mixed with alcohol, as this can cause death. People should not be afraid of taking trazodone if it is being used as directed.
How is trazodone addiction treated?
In the vast majority of cases, trazodone dependence will be present along with many other drugs. It is unusual for Trzodone to use alone. Because addiction to Transodon usually occurs along with other pharmaceutical and illegal drugs. inpatient treatment can be helpful.An inpatient program gives people who want to get rid of their trazodone addiction and continue to treat their mental problems with an individualized treatment plan.
Long-term trazodone users should undergo medical detoxification to get rid of addictive drugs. Medication Assisted Treatment (MAT) is available to users seeking to get rid of drug addiction. During detoxification, MAT relieves intense withdrawal symptoms.People can focus on recovery rather than the grueling aspects of recovery. MATs have the potential to reduce the likelihood of relapse during detoxification. In all cases, after detox, complex therapy should be carried out in order to rid the person of addiction.
Naltrexone for trazodone addiction
Although naltrexone is commonly used to treat severe trazodone addiction, it does not stop cravings for this drug. For this reason, naltrexone treatment for trazodone addiction usually begins after the detoxification and withdrawal phase and only under the supervision of a physician.
Naltrexone is a generic brand name tablet commonly prescribed under the brand names ReVia and Depade and is available in the United States, Canada and Europe. The extended release injectable formulation is often sold under the name Vivitrol and is available in different forms depending on the amount of medication needed per day.
Another form of naltrexone is a type of implant used in treatment that is shaped like a small ball and inserted into the lower abdominal wall.Upon implantation, the device releases a constant amount of naltrexone, and the drug can also be administered as a sustained-release injection every month.
Side effects of trazodone: what you need to know
Disclaimer
If you have any medical questions or concerns, please contact your doctor. Articles in the Health Guide are based on peer-reviewed research and information gleaned from medical societies and government agencies.However, they are not a substitute for professional medical advice, diagnosis, or treatment.
Depression is not just sadness or depression. This mood disorder can affect all aspects of life, including your appetite, weight, sleep, work, and relationships (NIMH, 2018).
While we don’t yet know exactly how depression works, we do know it has to do with the balance of certain chemicals in the brain (Chand, 2020). Prescription medications such as trazodone can help by affecting the levels of these chemicals.However, you may be concerned about the possible side effects of these prescription drugs. Here’s what you need to know if you are talking with your doctor about trazodone.
Vitals
- Trazodone is a prescription drug approved for the treatment of major depressive disorder (MDD). It can be used off-label to treat insomnia in people with depression or anxiety in people with dementia.
- The most common side effects of trazodone are drowsiness, nausea, dizziness and dry mouth.
- Taking certain medicines with trazodone can increase the chance of side effects, in which case your doctor may adjust your treatment regimen.
What are the side effects of trazodone?
Most common side effects of trazodone are drowsiness, nausea, dizziness, and dry mouth (Zhang, 2014). Trazodone is generally well tolerated and less likely than some other antidepressants to cause insomnia, sexual side effects, and anxiety (Shin, 2020).
Clinical trials have also been reported. other side effects including blurred vision, constipation, confusion, fatigue, nervousness, tremors, and weight changes (FDA, 2017).
You may be more likely to experience side effects if you are taking certain medications with trazodone. For example, there are medications that can affect a system in your liver called CYP3A4, which breaks down trazodone (Shin, 2020). These medications can slow down this system, leading to a build-up of trazodone in the body.In other words: Elevated trazodone levels mean an increased risk of potential side effects (NIH, 2017).
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Serious side effects of trazodone
Although not so common, trazodone can cause serious side effects.
The drug can cause too high levels of serotonin in the body, leading to a condition called serotonin syndrome.Usually, chemical messengers (also known as neurotransmitters) carry messages between brain cells. Serotonin is a type of neurotransmitter. Researchers suggest that medications such as trazodone can help relieve depression by keeping serotonin levels high in the brain.
However, abnormally high serotonin levels can cause mild to life-threatening side effects (Volpi-Abadie, 2013). Symptoms of serotonin syndrome include agitation, anxiety, disorientation, skin redness, heart palpitations, nausea, anxiety, sweating, tremors, and vomiting.Shaking is especially common (Simon, 2020). Trazodone can also cause fainting, irregular heartbeat, chest pain, seizures, shortness of breath, or shortness of breath (NIH, 2017). See your doctor right away if you develop any of these symptoms.
Because the side effects of trazodone are dose dependent, you are more likely to experience side effects when you take the higher doses (Jaffer, 2017). Tell your doctor how you are feeling so they can find the right dose for you.A healthcare professional can work with you to find the lowest dose that effectively treats your depression in order to minimize the side effects you experience.
What is Trazodone?
Trazodone is a generic drug (also sold under the brand names Desyrel and Oleptro) approved by the FDA for the treatment of major depressive disorder (MDD) (FDA, 2017). Trazodone works by increasing the levels of available serotonin in the brain, which helps relieve symptoms of depression (NIH, 2017).
Trazodone is also used off-label (in a way not specifically approved by the FDA) to treat insomnia, especially in people with depression. Chronic insomnia is different from the common sleep problems we all encounter from time to time. This condition can cause sleep problems for a month or more. If you suffer from this kind of insomnia, you may be prescribed trazodone to restore your sleep patterns. Trazodone is also used off-label to treat agitation in people with dementia.
Trazodone warnings
Trazodone carries a black box warning from the US Food and Drug Administration, which states the following (FDA, 2017): Some antidepressants, including trazodone, have an increased risk of suicidal thoughts and behavior. especially in children, adolescents and young adults. Families and caregivers should be aware of this risk, especially during the first few months of therapy or after dose increases.They should also watch closely for suicidal thoughts, attempts or endings, and other mood changes. Trazodone is not approved by the FDA for use in people under the age of 18.
Patients with trazodone diagnosed with MDD may be at risk of attempting suicide or self-harm (Coupland, 2014). A healthcare professional can work with you and your family to manage the severity of your depression symptoms, especially when you first take your medication or after you change your dosage.
Trazodone tends to cause less anxiety and insomnia and fewer sexual side effects than some other SSRIs and SNRIs, but that does not mean it has no side effects (Shin, 2020). It can also cause anxiety, agitation, panic attacks, sleep disturbances, irritability, hostility, impulsivity, and movement disorders. If you experience any of this, tell your doctor, who may stop or change your medication.This is also the reason why trazodone should not be given to people with a history of bipolar disorder.
If you suddenly stop taking trazodone, you may experience a so-called withdrawal syndrome (NIH, 2017). This is when patients who have been taking antidepressants for at least six weeks experience the side effects of abruptly stopping treatment. About one in five people have withdrawal symptoms, which symptoms can include balance problems, feeling like you have the flu, nausea, and trouble sleeping.It can take up to two weeks for these symptoms to resolve (Warner, 2006). If you want to stop taking trazodone, talk to your doctor so that you can do it gradually and safely.
Trazodone interactions
Trazodone should not be taken with other medications or OTC supplements that increase serotonin levels. The main ones to avoid (NIH, 2017) are:
- MAOI
- Triptans
- Tricyclic antidepressants
- Selective serotonin reuptake inhibitors (SSRIs)
- Fentanyl

Trazodone common side effects: Common and Rare Side Effects for trazodone oral

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Trazodone tablets

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Top 12 Facts about Trazodone

Is Trazodone Addictive? (Abuse, Overdose & Treatment)

What is Trazodone?

Is Trazodone Addictive?

What is Trazodone Used For?

Risks of Trazodone

Suicidal Thoughts

Serotonin Syndrome

Antidepressant Discontinuation Syndrome

Side Effects of Trazodone

Trazodone Overdose

Trazodone Interactions

Trazodone Abuse & Addiction Symptoms

Addiction Treatment

Summary

Trazodone Addiction – Transformations Treatment Center

Common Side Effects of Trazodone

Need More Information?

How Trazodone Works Within Your Body

How to Identify Problematic Trazodone Use

How to Treat Trazodone Misuse

Side effects and risks of trazodone

Can a person overdose on trazodone?

How is trazodone addiction treated?

Naltrexone for trazodone addiction

Side effects of trazodone: what you need to know

Disclaimer

Vitals

What are the side effects of trazodone?

Serious side effects of trazodone

What is Trazodone?

Trazodone warnings

Trazodone interactions

Recommendations

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Main characteristics of trazodone

Important warnings Real warnings

FDA warning: suicide warning

What is trazodone?

Why is it used

How it works

Side effects Trazodone side effects

More common side effects

Serious side effects

Interactions Trazodone may interact with other drugs

Drugs you should not use with trazodone

Interactions that may cause more side effects