How effective is trazodone for treating insomnia and depression. What are the most common side effects reported by patients. How does trazodone compare to other sleep medications and antidepressants.

Understanding Trazodone: An Overview of Its Uses and Effects

Trazodone is a medication primarily prescribed for depression, but it’s also commonly used off-label to treat insomnia and anxiety. As an antidepressant and sedative, trazodone affects brain chemicals like serotonin to help regulate mood and sleep patterns. Many patients find it effective, but experiences can vary significantly.

How does trazodone work in the body? Trazodone acts as a serotonin antagonist and reuptake inhibitor (SARI). It blocks serotonin receptors and prevents the reabsorption of serotonin in the brain, allowing more to remain available. This mechanism is thought to help alleviate depression and promote sleep.

Trazodone for Insomnia: Patient Experiences and Effectiveness

Many patients report positive experiences using trazodone for chronic insomnia. One long-term user shared: “I’ve had insomnia since I was a kid. I started taking trazodone at least 25 years ago. Trazodone has made me a happy regular sleeper. I usually fall asleep quickly and stay asleep.”

How quickly does trazodone typically work for sleep? Some users report feeling effects within 20-30 minutes of taking it. One reviewer advised: “I take my dose and wait 20 min. or so until I feel it coming on, then it puts me to sleep very well and quickly.” However, the onset and effectiveness can vary between individuals.

Dosage Considerations for Insomnia

Finding the right dosage of trazodone for sleep can require some trial and error. A patient described their experience: “50 mg didn’t work at all so I took two 50 mg. It only made me sleepy but I still couldn’t sleep. I took Three 50 mg tablets, I was finally able to sleep well.” Patients should work closely with their doctor to find the optimal dose.

Trazodone for Depression: Effectiveness and Patient Satisfaction

While primarily known for its sleep-inducing effects, trazodone is an antidepressant at its core. Some patients find it helpful for managing depression symptoms. One user noted: “Seems to make me feel better than usual, better sleep.”

Is trazodone as effective for depression as other antidepressants? The effectiveness can vary, and some patients may find other medications more suitable. Trazodone is often prescribed when sleep disturbances are a significant component of depression.

Common Side Effects and Concerns with Trazodone Use

Like all medications, trazodone can cause side effects. Some commonly reported issues include:

• Dizziness
• Dry mouth
• Blurred vision
• Daytime drowsiness
• Nausea

One patient described their experience with side effects: “Morning: dizzy, shaky, nausea, dry mouth, dry eyes, headache. Worst, my heart rate was jumping up and down… Got up to 140!!!” It’s crucial to report severe side effects to a healthcare provider immediately.

Long-Term Side Effects and Concerns

Some users report experiencing long-term side effects from trazodone use. A patient shared their story: “For 13 YEARS I suffered from constantly worsening debilitating nausea and feeling like I could constantly vomit. I stopped taking it and the nausea was immediately gone.” This highlights the importance of ongoing communication with healthcare providers about any persistent symptoms.

Comparing Trazodone to Other Sleep Medications

How does trazodone compare to other sleep aids? Unlike many sleep medications, trazodone is not habit-forming and can be used long-term. It may be preferred for patients with a history of substance abuse or those who have not responded well to other sleep aids.

Are there any advantages to using trazodone over traditional sleep medications? Trazodone may offer benefits for patients who also experience depression or anxiety, as it can address multiple issues simultaneously. However, its sedating effects may be stronger or longer-lasting than some prefer.

Tips for Optimal Use of Trazodone

To maximize the benefits of trazodone while minimizing side effects, consider the following tips:

1. Take trazodone at the same time each night to establish a routine.
2. Allow enough time for a full night’s sleep to avoid daytime drowsiness.
3. Start with a low dose and gradually increase if needed, under doctor’s guidance.
4. Avoid alcohol and other central nervous system depressants while taking trazodone.
5. Be patient, as it may take several weeks to experience the full effects.

How soon before bedtime should trazodone be taken? Based on patient experiences, taking trazodone about 30 minutes before desired sleep time seems to work well for many. However, individual responses may vary.

Potential Drug Interactions and Precautions

Trazodone can interact with various medications and substances. Some important interactions to be aware of include:

• Other antidepressants, particularly MAOIs
• Blood thinners like warfarin
• Certain antifungal medications
• Some antibiotics
• Drugs that affect serotonin levels

Can trazodone be safely combined with other psychiatric medications? While it’s often used in combination with other drugs, this should only be done under close medical supervision. The risk of serotonin syndrome, a potentially dangerous condition, increases when multiple serotonergic drugs are combined.

Special Considerations for Certain Populations

Trazodone may require special consideration in certain groups:

• Elderly patients may be more sensitive to side effects and may require lower doses.
• Pregnant women should discuss the risks and benefits with their healthcare provider.
• Patients with a history of heart problems should be monitored closely.
• Those with a history of bipolar disorder may be at risk for manic episodes.

Discontinuing Trazodone: What Patients Should Know

Stopping trazodone abruptly can lead to discontinuation symptoms. These may include:

• Anxiety
• Irritability
• Sleep disturbances
• Dizziness
• Nausea

How should patients safely discontinue trazodone use? It’s generally recommended to taper off the medication gradually under medical supervision. This can help minimize withdrawal symptoms and allow the body to adjust.

Rebound Insomnia Concerns

Some patients may experience a temporary worsening of sleep problems when stopping trazodone. This “rebound insomnia” is typically short-lived but can be distressing. Gradual tapering and implementing good sleep hygiene practices can help manage this transition.

Alternative Treatments for Insomnia and Depression

While trazodone can be effective, it’s not the only option for managing insomnia and depression. Some alternatives include:

• Cognitive Behavioral Therapy for Insomnia (CBT-I)
• Other antidepressants (SSRIs, SNRIs)
• Non-benzodiazepine sleep aids (e.g., zolpidem, eszopiclone)
• Melatonin supplements
• Lifestyle changes (sleep hygiene, exercise, stress reduction)

Are there natural alternatives to trazodone for sleep and mood? Some patients find relief with herbal remedies like valerian root or chamomile tea. However, the effectiveness of these options can vary, and they should be discussed with a healthcare provider before use.

The Importance of Individualized Treatment

Patient experiences with trazodone highlight the importance of individualized treatment approaches. What works well for one person may not be suitable for another. Factors such as overall health, other medications, lifestyle, and personal preferences all play a role in determining the best treatment plan.

How can patients work with their healthcare providers to find the right treatment? Open communication is key. Patients should feel comfortable discussing their symptoms, concerns, and treatment goals with their doctor. Regular follow-ups and a willingness to adjust the treatment plan as needed can lead to better outcomes.

The Role of Comprehensive Mental Health Care

While medication can be an important part of treatment for insomnia and depression, it’s often most effective when combined with other therapies. Psychotherapy, lifestyle changes, and support groups can all contribute to better overall mental health and well-being.

Trazodone, like any medication, comes with both benefits and potential risks. Patient experiences vary widely, from those who find it life-changing to others who struggle with side effects. By understanding the medication, working closely with healthcare providers, and being attuned to their own bodies, patients can make informed decisions about whether trazodone is the right choice for their needs.

Effectiveness, Ease of Use, and Satisfaction

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Most voted positive review

99 People found this comment helpful

I take my dose and wait 20 min. or so until I feel it coming on, then it puts me to sleep very well and quickly. I feel taking it and going right to bed is not as effective as waiting till you feel results, regaurdless of what my doctor says. Don’t wait too long to go to bed though, when you feel a little light headed, lay down immediatly. If you wait too long it feels like it is not as effecti…

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Most voted negative review

34 People found this comment helpful

This medicine almost killed me yesterday

Shared reviews and ratings

SORT BY Condition: insomnia associated with depression

Overall rating 1. 0

EffectivenessEase of UseSatisfaction

Took med finally able to fall asleep.. morning:dizzy ..shaky..nausea..dry mouth dry eyes…headache
worst my heart rate was jumping up and down..if It. Got up to 140!!! Should have called 911 but waited and dropped somewhat .. following
Day chills still irregular heart rate listen to your druggist who was concerned about my using this drug!!!

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Fill 3Created with Sketch. Condition: insomnia associated with depression

Overall rating 4.0

EffectivenessEase of UseSatisfaction

Easy to use. Helps anxiety and sleep

1

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Fill 3Created with Sketch. Condition: Depression

Overall rating 4. 0

EffectivenessEase of UseSatisfaction

Seems to make me feel better than usual better sleep le

1

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Fill 3Created with Sketch. Condition: insomnia associated with depression

Overall rating 5.0

EffectivenessEase of UseSatisfaction

I suffer from insomnia and it is the only medication that allows me to have a decent night of rest

1

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Fill 3Created with Sketch. Condition: Chronic Trouble Sleeping

Overall rating 5.0

EffectivenessEase of UseSatisfaction

I’ve had insomnia since I was a kid. I started taking trazodone at least 25 years ago. Trazodone has made me a happy regular sleeper. I usually fall asleep quickly and stay asleep. I’ve had friends who have felt knocked out by it. But for me, it’s made a big impact on my quality of life.

1

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Fill 3Created with Sketch. Condition: Chronic Trouble Sleeping

Overall rating 2.7

EffectivenessEase of UseSatisfaction

With chronic conditions, they jam antidepressants down our throats claiming they will help for so many “off label” uses. Very rarely they actually explain some possible side effects such as anxiety, depression, nausea, etc, they NEVER explain that just like the desired effects of the meds, the side effects also take time to start and to build up. You’re not just super anxious or depressed or vomiting the next day. Could be weeks or months. So by then you never suspect this antidepressant they force down your throat is what’s causing these horrible side effects. For 13 YEARS I suffered from constantly worsening debilitating nausea and feeling like I could constantly vomit. I stopped taking it and the nausea was immediately gone. But also was the horrendous debilitating anxiety that had been plaguing me all these years. had me wound tighter than 1000lbs spring. Lost everybody in my life due to it. Including my son and granddaughter, only happiness left in my life. Does anybody else find it interesting that then whenever we complain about a new symptom or wanting further testing in the future, all these doctors claim we’re just depressed. But then guess what, how much can we argue because we all just happen to be on antidepressants?!?! Just a coincidence, I don’t think so.Read More Read Less

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Fill 3Created with Sketch. Condition: Chronic Trouble Sleeping

Overall rating 2.0

EffectivenessEase of UseSatisfaction

50 mg didn’t work at all so I took two 50 mg. It only made me sleepy but I still couldn’t sleep. I took Three 50 mg tablets, I was finally able to sleep well. When I finished all the 30 tablet, I was prescribed 150 mg (a whole tablet). It didn’t work at all! I took it for 2 nights no, it didn’t work at all. What’s the difference between taking 3- 50mg tabs and taking one150mg tablet? That puzzles me.

1

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Fill 3Created with Sketch. Condition: Chronic Trouble Sleeping

Overall rating 2.3

EffectivenessEase of UseSatisfaction

Trazadone caused my heart to malfunction. Put me in the ER twice. I had no idea that Trazadone was the problem until I stopped taking it. I say this with 100% certainty. That’s just me. Hopefully, your experience is not the same.

1

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Fill 3Created with Sketch. Condition: Chronic Trouble Sleeping

Overall rating 5.0

EffectivenessEase of UseSatisfaction

I get good sleep nightly. I am out in less than ten minutes

1

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Fill 3Created with Sketch. Condition: Chronic Trouble Sleeping

Overall rating 1.0

EffectivenessEase of UseSatisfaction

Took 150 mg to get to sleep. Feel hungover, have headache, eyes hurt & blurry. Going back to Benadryl.

1

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Fill 3Created with Sketch. Condition: Other

Overall rating 3.7

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1st time ever in life of 60 years old male to take pharma meds as the THC is not enough to cope
my first dose– slept straight for 10 hours without waking up with my BPH Benign Prostatix Hyperpoalsia_prostate issues. ..so this meds is good does the job,,,,,but it’s my 1st dose so i shall see and observe for 3 mth the doc gave me…………..

1

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Fill 3Created with Sketch. Condition: Other

Overall rating 1.0

EffectivenessEase of UseSatisfaction

Basically I took 50mg for the first time last night. Because of the mCPP in it that’s a know anxiety causing agent, I had a panic attack with heart palpitations, shortness of breath, & feelings of panic and overwhelm. It may work for other people, but it just didn’t work for me unfortunately.

1

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Fill 3Created with Sketch. Condition: Chronic Trouble Sleeping

Overall rating 2.3

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ALL YOU PEOPLE THAT SAID WAS BAD YOUR WRONG
ITS WORSE THAN THAT ITS 901 IN THE NORING WORST HANG OVER EVER
1ST DAY THOUGHT IT WAS GREAT I WAS WRONG LAST NIGHT WAS DAY 5 THIS IS THE WORST I EVER FELT
SO YOU NEW PEOPLE B CAREFULL
IM BOB IN PITTSBURGH

1

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Fill 3Created with Sketch. Condition: insomnia associated with depression

Overall rating 2.3

EffectivenessEase of UseSatisfaction

It’s it not only a sleep medication but also a depressant. The pills are not worth it! The first week I felt just fine, slept well and I can say as first I felt as if I was in a better mood. But it’s really just a mind thing. (Medicine to make you “feel” better). It has been about two weeks. Had the worst/ most realistic dream I’ve ever had today. Feel shaky after waking up( not from the dream) Lower back hurts after taking this medication and I was only taking 50mg couldn’t imagine keeping this medication not a second longer.. I wouldn’t recommend for your health/ safety. Read More Read Less

1

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Fill 3Created with Sketch. Condition: Other

Overall rating 1.0

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I took trittico as an alternative for zinovat because my doctor told me it would be better. Since I had it, I was dizzy, nauseous, blurry vision, extreme headache, felt like I’m gonna pass out AND I threw up. Had these for a whole day. Never taking it again. Really bad experience.

1

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Fill 3Created with Sketch. Condition: Major Depressive Disorder

Overall rating 4.0

EffectivenessEase of UseSatisfaction

No major issues or side effects. I have had vivid & scary dreams at times. I take 150 mg nightly and sleep solid.

1

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Overall rating 1.0

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I have taken Trazodone for almost 40 years over the past few years I started developing debilitating neuromuscular issues. From severe headaches, muscle weakness and cramps and paralysis. I have been to several Neurologist and testing no answers My condition is now debilitating. His only response was it is a great possibility that long term use can cause these symptoms

1

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Fill 3Created with Sketch. Condition: insomnia associated with depression

Overall rating 1.7

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I have taken Trazodone for almost 39 years. Over the years I have developed severe neurological and muscular issues. I have been to several neurologist with extensive testing and there is no answers to my debilitating condition. Along with years of horrible nightmares am wondering how a drug that was meant for use for a short period of time could have been prescribed for such a lengthy period

1

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Fill 3Created with Sketch. Condition: Chronic Trouble Sleeping

Overall rating 4.7

EffectivenessEase of UseSatisfaction

I want to post my experience because trazodone has worked wonderfully for me, to the point of changing my life for the better, and I often think that all the extreme negative reviews online can scare people off of what might be a very safe and effective treatment for them.
I’ve had disregulated sleep for most of my life. It might be related to anxiety, constant body aches, street noise, or it might be independent of all that. But I was at the point where I couldn’t treat my anxiety or even do more with my life than work, eat, and sleep because I was so tired all the time — not sleeping at night, then unable to get up in the morning. Taking half a lorazepam at night sometimes helped, but it wasn’t a good long-term solution. My psychiatrist told me that if I routinely found myself using lorazepam 3 or more nights a week to get to sleep on time, I should fill a Rx for trazodone and take half a pill nightly, instead, up to a whole pill if half wasn’t effective.
It has truly changed my life. I know it’s probably a temporary fix, but for now, I can just take it after dinner and reliably wind down over the next 1-2 hours. You hit a point where you’re almost dizzy sleepy, and that’s when you want to promptly get into bed. Taking it made me realize that I haven’t been naturally “starting to feel sleepy” since maybe 10th grade, and the lack of that sensation was causing me to NOT want to brush my teeth, get into pajamas, wrap up what I was doing, and climb into bed at night, because I literally felt no physical desire to. With trazodone, now I do, and maybe I can start retraining my body into it once more, if therapy and meds in combo can start to alleviate my anxiety — which is turning out to be less body-chemistry-based and more situational than I had realized.
It also doesn’t cause me any drowsiness or “drug hangover” the next day — it gets out of your system easily. In fact, the only complaint I have is that you can sort of “miss your window” with it, if you put off going to bed for too long.
My tips would be:
* Start with a low dose and see how much you need.
* Don’t give up if you experience some mild side effects at first. It gave me _serious_ drymouth for the first two weeks, but then it just cleared up completely once my body had adjusted to the med.
* Take it after eating dinner or a significant snack. It hits me HARD if I take it on an empty stomach — after 10 minutes, it hits all at once and I feel like I’m going to fall over (although I don’t). (That sort of extreme feeling can kick your anxiety into overdrive, too, so it isn’t necessarily the trazodone causing racing heart or panic or diarrhea, etc. ) But after a full dinner, it gives me a nice easy 2-hour descent into sleepiness.
Good luck to everyone, and I hope you all find the treatment plans that work best for each and every one of you. Read More Read Less

1

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Fill 3Created with Sketch. Condition: insomnia associated with depression

Overall rating 2.3

EffectivenessEase of UseSatisfaction

I sleep ok now but I add 300mg of quetiapine, melatonin, GABA and 5-HTP to the 100mg of Trazodone, so hard to say who is doing the heavy lifting (1mg of alprazolam worked just as good as all that but we don’t want to use what works) plenty of sleep but very odd dreams and wake up hungover. Anxiety and depression still the same….

1

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Trazodone Reviews & Ratings – Drugs.com

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Brand names:
Desyrel,
Desyrel Dividose

Trazodone
has an average rating of 6.3 out of 10 from a total of 1,380 reviews
on Drugs.com.
53% of reviewers reported a positive experience, while 31% reported a negative experience.

Condition	Avg. Rating	Reviews	Compare
Insomnia  Off-label		879 reviews	118 medications
Anxiety  Off-label		135 reviews	54 medications
Depression		134 reviews	77 medications
Sedation		130 reviews	37 medications
Fibromyalgia  Off-label		35 reviews	21 medications
Major Depressive Disorder		32 reviews	49 medications
Headache  Off-label		28 reviews	221 medications
Reflex Sympathetic Dystrophy Syndrome  Off-label		7 reviews	2 medications
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Danilkova Elena Viktorovna, psychiatrist – 18 reviews | Krasnodar

Patient
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June 22 at 19:11

Checked (2)

Visited in June 2023

“Mind Clinic”-per. Coal, d.

+2.0

Great

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Informing the patient

Would you recommend a doctor? Clinic “PsiMed” – st. Bazovskaya, 69

Patient
+7-922-65XXXXX

May 2 at 16:43

+2.0

Great

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Informing the patient

Would you recommend a doctor? Clinic “PsiMed” – st. Bazovskaya, 69

Patient
+7-918-95XXXXX

May 1 at 2:56 pm

-0. 6

Badly

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Informing the patient

Would you recommend a doctor? No 02 Clinic “PsiMed” – st. Bazovskaya, 69

Patient
+7-961-58XXXXX

April 19 at 11:53

+2.0

Great

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Informing the patient

Would you recommend a doctor? Clinic “PsiMed” – st. Bazovskaya, 69

Patient
+7-918-07XXXXX

March 23 at 11:09

+2.0

Great

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Would you recommend a doctor?

Excellent

Excellent

Excellent

Definitely

Checked (2)

Visited in March 2023

Bazovskaya, 69

Patient
+7-918-14XXXXX

January 28 at 13:17

+2. 0

Great

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Informing the patient

Would you recommend a doctor? Clinic “PsiMed” – st. Bazovskaya, d.

+2.0

Great

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Informing the patient

Would you recommend a doctor? Clinic “PsiMed” – st. Bazovskaya, d.

+2.0

Great

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Informing the patient

Would you recommend a doctor? Clinic “PsiMed” – st. Bazovskaya, d.

-0.4

Fine

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Informing the patient

Would you recommend a doctor? No 2 Clinic “PsiMed” – st. Bazovskaya, d.

+2.0

Great

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Informing the patient

Would you recommend a doctor? Clinic “PsiMed” – st. Bazovskaya, d.

+2.0

Great

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Would you recommend a doctor? Clinic “PsiMed” – st. Bazovskaya, d.

+2.0

Great

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Would you recommend a doctor? Clinic “PsiMed” – st. Bazovskaya, d.

+2.0

Great

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Informing the patient

Would you recommend a doctor? Clinic “PsiMed” – st. Bazovskaya, d.

+1.8

Great

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Would you recommend a doctor?

Excellent

Excellent

Excellent

Good

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Checked (2)

Visited in May 2019

Regional psychiatric hospital-st.