What are the uses of Tri-Estarylla 28 Day Pack. How should it be taken. What are the potential side effects and precautions. What should patients know about this birth control medication.

Understanding Tri-Estarylla 28 Day Pack: A Comprehensive Guide

Tri-Estarylla 28 Day Pack is a widely prescribed medication that serves multiple purposes in women’s health. This article delves into the various aspects of this medication, including its uses, proper administration, potential side effects, and important precautions.

Primary Uses of Tri-Estarylla 28 Day Pack

Tri-Estarylla 28 Day Pack is primarily used for the following purposes:

• Birth control
• Treatment of acne
• Management of depression
• Addressing endocrine disorders
• Alleviating menstrual problems

Its versatility in addressing multiple health concerns makes it a popular choice among healthcare providers and patients alike.

Effectiveness as a Contraceptive Method

How effective is Tri-Estarylla 28 Day Pack as a birth control method? When taken correctly and consistently, this medication is highly effective in preventing pregnancy. Its combination of hormones works to prevent ovulation, thicken cervical mucus, and alter the uterine lining, making it difficult for sperm to reach and fertilize an egg.

Proper Administration and Dosage Instructions

To ensure maximum effectiveness and minimize potential side effects, it’s crucial to follow the proper administration guidelines for Tri-Estarylla 28 Day Pack:

1. Take the medication at approximately the same time each day.
2. Can be taken with or without food.
3. Store at room temperature, away from heat and direct light.
4. For first-time users, consult with a doctor about when to start the medication.
5. When switching from a different birth control pill, start Tri-Estarylla on the same day you would start your other birth control pack.

Managing Missed Doses

How should patients handle missed doses of Tri-Estarylla? If you forget to take a dose, take it as soon as you remember. If it’s close to the time for your next dose, you may take two doses at once. Return to your regular dosing schedule the following day. For multiple missed doses, consult your doctor for guidance on getting back on schedule.

Potential Side Effects and Monitoring

While Tri-Estarylla 28 Day Pack is generally well-tolerated, it’s important to be aware of potential side effects:

• Bloating
• Breast pain or swelling
• Swelling of the legs, feet, and hands
• Headaches
• High blood pressure
• Menstruation changes (missed or fewer periods)
• Nausea
• Stomach upset or abdominal pain
• Vaginal bleeding or spotting between periods
• Vomiting
• Weight gain

Patients should monitor these symptoms and report any persistent or severe side effects to their healthcare provider.

Serious Side Effects Requiring Immediate Attention

Which side effects of Tri-Estarylla require immediate medical attention? Patients should seek medical help right away if they experience:

• Severe or persistent abdominal pain
• Breast lumps
• Chest pain or shortness of breath
• Severe headaches or migraines
• Vision changes or eye problems
• Severe leg pain or swelling

Important Precautions and Interactions

To ensure safe and effective use of Tri-Estarylla 28 Day Pack, patients should be aware of the following precautions:

• Inform healthcare providers about any allergies or previous adverse reactions to medications.
• Avoid smoking while taking this medication, as it increases the risk of cardiovascular complications.
• Perform regular breast self-examinations and report any changes to a doctor.
• Use condoms to reduce the risk of sexually transmitted diseases.
• Do not use if pregnant or planning to become pregnant.
• Avoid taking St. John’s wort while on this medication.

Drug Interactions and Contraindications

Are there any medications that interact with Tri-Estarylla? Yes, several medications can interact with Tri-Estarylla, potentially affecting its effectiveness or increasing the risk of side effects. Patients should inform their healthcare providers about all medications they are taking, including prescription drugs, over-the-counter medicines, vitamins, and herbal supplements.

Managing Specific Health Conditions

Patients with certain health conditions should take special precautions when using Tri-Estarylla 28 Day Pack:

Diabetes Management

How does Tri-Estarylla affect blood sugar levels in diabetic patients? This medication may affect blood sugar levels. Diabetic patients should consult their doctor before changing the dose of their diabetes medication and monitor their blood sugar levels closely while taking Tri-Estarylla.

Skin Changes and Sun Exposure

Tri-Estarylla may cause dark patches to appear on the face. To minimize further darkening of these skin patches, patients should avoid excessive sun exposure and use sunscreen regularly.

Maintaining Regular Medical Check-ups

Regular medical check-ups are essential for patients taking Tri-Estarylla 28 Day Pack. These appointments allow healthcare providers to monitor the medication’s effectiveness, assess any potential side effects, and make necessary adjustments to the treatment plan.

Importance of Annual Physical Exams

Why are annual physical exams crucial for patients on Tri-Estarylla? Annual physical exams provide an opportunity for comprehensive health assessments, including breast examinations, pelvic exams, and blood pressure checks. These exams help detect any potential issues early and ensure the continued safe use of the medication.

Addressing Common Concerns and Questions

Patients often have questions about using Tri-Estarylla 28 Day Pack. Here are some common concerns addressed:

Missed Periods

What should patients do if they miss a period while taking Tri-Estarylla? If a patient misses their period while on this medication, they should contact their doctor. While occasional missed periods can occur, it’s important to rule out pregnancy or other underlying issues.

Vomiting and Diarrhea

How do vomiting and diarrhea affect the effectiveness of Tri-Estarylla? Severe vomiting or diarrhea can prevent birth control pills from working effectively. In such cases, patients may need to use additional forms of contraception, such as condoms. It’s advisable to consult a healthcare provider for guidance in these situations.

Switching from Other Birth Control Methods

When switching from a different birth control method to Tri-Estarylla, patients should follow their healthcare provider’s instructions carefully. The timing of starting Tri-Estarylla may vary depending on the previous method used.

Understanding the proper use, potential side effects, and necessary precautions associated with Tri-Estarylla 28 Day Pack is crucial for its safe and effective use. Patients should maintain open communication with their healthcare providers and report any concerns or unusual symptoms promptly. By following these guidelines and staying informed, patients can maximize the benefits of this medication while minimizing potential risks.

Tri-Estarylla 28 Day Pack

Uses

This medicine is used for the following purposes:

• acne
• birth control
• depression
• endocrine disorder
• menstrual problem

Instructions

This medicine may be taken with or without food.

It is very important that you take the medicine at about the same time every day. It will work best if you do this.

Keep the medicine at room temperature. Avoid heat and direct light.

If this is the first time that you are using this medicine, please speak with your doctor about when you should start this medicine.

If you are switching from a different birth control pill, start this medicine on the same day you would start your other birth control pack.

If you are using a birth control pack with 28 pills, start the first pill of a new pack on the day after the last pill of the previous pack.

If you are using a birth control pack that has 21 pills, wait 7 days after taking the last pill of the empty pack before you take the first pill of a new pack.

If you forget to take a dose, take it as soon as you remember. If it is time for your next dose, you are allowed to take 2 doses at once. Return to your normal dosing schedule on the following day. If you miss more than one dose, ask your doctor what you should do to get back on schedule.

Speak with your doctor about using additional forms of birth control if you forget one or more doses of your medicine.

Some patients may have mild vaginal bleeding or spotting while on this medicine. If this happens, do not stop taking this medicine. If the bleeding or spotting lasts more than a few days or becomes heavier, contact your doctor.

This medicine may cause dark patches to appear on your face. Avoid sunlight and use sunscreen lotion to minimize further darkening of these skin patches.

Please tell your doctor and pharmacist about all the medicines you take. Include both prescription and over-the-counter medicines. Also tell them about any vitamins, herbal medicines, or anything else you take for your health.

This medicine may affect your blood sugar levels. If you have diabetes, talk to your doctor before changing the dose of your diabetes medicine.

Vomiting or diarrhea can prevent birth control pills from working well. If you have vomiting or diarrhea, you may need to use an extra form of birth control (such as condoms). Check with your doctor or pharmacist if you have questions.

This medicine may interfere with some lab test results. Be sure to tell all your healthcare providers that you are taking this medicine.

It is very important that you keep all appointments for medical exams and tests while on this medicine.

Cautions

Tell your doctor and pharmacist if you ever had an allergic reaction to a medicine. Symptoms of an allergic reaction can include trouble breathing, skin rash, itching, swelling, or severe dizziness.

Avoid smoking while on this medicine. Smoking may increase your risk for stroke, heart attack, blood clots, high blood pressure, and other diseases of the heart and blood vessels.

If you miss your period while on this medicine, contact your doctor.

Ask your doctor to show you how to perform a self breast examination. You should check your breasts once a month and report any changes to your doctor.

Talk to your doctor about getting a complete physical exam every year while on this medicine.

Use condoms to reduce the risk of sexually transmitted diseases.

Tell the doctor or pharmacist if you are pregnant, planning to be pregnant, or breastfeeding.

Do not use this medicine if you are pregnant. If you become pregnant while on this medicine, contact your doctor immediately.

Do not take St. John’s wort while on this medicine.

Ask your pharmacist if this medicine can interact with any of your other medicines. Be sure to tell them about all the medicines you take.

Please tell all your doctors and dentists that you are on this medicine before they provide care.

Do not start or stop any other medicines without first speaking to your doctor or pharmacist.

Do not share this medicine with anyone who has not been prescribed this medicine.

Side Effects

The following is a list of some common side effects from this medicine. Please speak with your doctor about what you should do if you experience these or other side effects.

• bloating
• breast pain or swelling
• swelling of the legs, feet, and hands
• headaches
• high blood pressure
• menstruation changes (missed or fewer periods)
• nausea
• stomach upset or abdominal pain
• vaginal bleeding or spotting between periods
• vomiting
• weight gain

Call your doctor or get medical help right away if you notice any of these more serious side effects:

• severe or persistent abdominal pain
• breast lumps
• chest pain
• changes in memory, mood, or thinking
• depression or feeling sad
• fainting
• severe or persistent headache
• jaw pain
• sudden leg pain, swelling, warmth or redness
• symptoms of liver damage (such as yellowing of skin or eyes, dark urine, unusual tiredness or weakness; severe stomach or back pain)
• shortness of breath
• symptoms of stroke (such as one-sided weakness, slurred speech, confusion)
• blurring or changes of vision

A few people may have an allergic reaction to this medicine. Symptoms can include difficulty breathing, skin rash, itching, swelling, or severe dizziness. If you notice any of these symptoms, seek medical help quickly.

Extra

Please speak with your doctor, nurse, or pharmacist if you have any questions about this medicine.

https://krames.meducation.com/V2.0/fdbpem/115

IMPORTANT NOTE: This document tells you briefly how to take your medicine, but it does not tell you all
there is to know about it.Your doctor or pharmacist may give you other documents about your medicine.
Please talk to them if you have any questions.Always follow their advice. There is a more complete
description of this medicine available in English.Scan this code on your smartphone or tablet or use
the web address below. You can also ask your pharmacist for a printout. If you have
any questions, please ask your pharmacist.

© 2021 First Databank, Inc.

Tri-Lo-Estarylla Delivery Options, Uses, and Side Effects

☆☆☆☆☆

4.8 | 26485
reviews

Why Nurx?

• Free, fast shipping with automatic refills. Easily pause or cancel anytime

• FDA approved medication & affordable out-of-pocket prices

• Unlimited messaging for one year with licensed providers

Product details

Tri-Lo-Estarylla is a combination hormonal-based birth control pill. Tri-Lo-Estarylla also has many positive side effects, including less painful periods and acne treatment, as well as pregnancy prevention. If you have a history of blood clots or are pregnant or breastfeeding, Tri-Lo-Estarylla may not be right for you.

At this time Nurx only offers Tri-Lo-Estarylla for pickup at your local pharmacy, but we carry similar birth control options available for delivery. Just answer a few quick questions and one of our licensed providers will help find the birth control that’s right for you. Click here to get started.

Additional Details

How It Works

You Choose

Select your medication, or get guidance from our medical team. Answer a few questions and enter your insurance info (if you have coverage – if not, no problem)

We Prescribe

A Nurx provider in your state will review your request and write a prescription, if appropriate

Delivered Free

We deliver your medication directly to you. On time, in a discreet package, and with no added costs

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“Demand for Nurx’s services skyrocketed — order volume for emergency contraception, birth control, sexually transmitted infection tests grew 40%, 50% and 100%, respectively. Its total sales climbed 80% year-over-year in 2020”

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“For $35, all patients with mild to moderate acne—whether they’re insured or not—can receive an initial medical consultation, home delivery of medications, and a 10-week follow-up.”

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Best for: Anyone who hasn’t been tested for STIs in more than a year (or ever) and just wants a no-rush STI checkup.”

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Memorial Sloan Kettering Cancer Center

Adult Medication

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This document, provided by Lexicomp ^® , contains all the information you need to know about this medicine, including indications, directions for use, side effects, and when your healthcare provider should be contacted.

Trade names: USA

Trelstar Mixject; Triptodur

Trade names: Canada

Decapeptyl; Trelstar

What is this drug used for?

• Used to treat prostate cancer. If you have been taking this drug for any other reason, ask your doctor for more information.

What should I tell my doctor BEFORE taking this drug?

• If you have an allergy to this drug, any of its ingredients, other drugs, foods or substances. Tell your doctor about your allergies and how they have manifested.
• If you are able to become pregnant or breastfeed. This drug is not approved for use in these patients. If you are pregnant, planning to become pregnant or breastfeeding, please consult your doctor.

Combining this drug with certain drugs and conditions may be unfavorable.

Tell your doctor and pharmacist about all medicines you take (prescription and over-the-counter, natural products and vitamins) and any health problems you have. You need to make sure that this drug is safe for your conditions and in combination with other drugs you are already taking. Do not start or stop taking any drug or change the dosage without your doctor’s advice.

What do I need to know or do while taking this drug?

• Tell all your health care workers that you are taking this drug. These are doctors, nurses, pharmacists and dentists.
• Perform blood tests and other laboratory tests as directed by your doctor.
• This drug may affect the results of some lab tests. Tell all your health care workers and laboratory staff that you are taking this drug.
• This drug has been associated with high blood sugar. This includes the development or worsening of pre-existing diabetes.
• Check your blood sugar as directed by your doctor.
• Testosterone levels may rise during the first few weeks after starting these medications. As a result, signs of prostate cancer may progress during this period. Tell your doctor if you develop any new signs such as bone pain; unusual burning, numbness, or tingling; blood in the urine or problems with urination. Tell your doctor if signs of prostate cancer get worse for longer than a few weeks after you start taking this drug.
• This drug lowers the level of certain hormones in the body. This can lead to things like changes in breast size, breast tenderness or tenderness, testicular changes, trouble getting or keeping an erection, decreased interest in sex, hot flashes, or sweating. Consult your doctor.
• Decreased levels of male sex hormones in the body can increase the risk of an abnormal heart rhythm called QT prolongation. Consult with your doctor.
• People with a blocked bladder may be more likely to have serious and sometimes fatal problems. The risk may also be increased in people with growths on or near the spine or spinal cord. If you have any questions, please consult your doctor.
• This drug can cause broken bones. This phenomenon is observed more often with prolonged use of the drug. This may increase the likelihood of bone fractures. If you experience bone pain, contact your doctor immediately.
• The use of drugs like this one in children was accompanied by changes in behavior and mood. These changes include aggression, crying, depression, emotional ups and downs, anxiety, and feelings of anger and irritability. If you experience or worsen behavioral or mood changes, contact your doctor immediately.
• This drug may affect a man’s ability to have a child. Consult your doctor.

What side effects should I report to my doctor immediately?

WARNING. In rare cases, this drug can cause serious and sometimes deadly side effects in some patients. Contact your doctor or seek medical attention right away if you have any of the following signs or symptoms that may be associated with serious side effects:

• Signs of an allergic reaction, such as rash, hives, itching, red and swollen skin with blisters or peeling, possibly accompanied by fever, wheezing or wheezing, tightness in the chest or throat, difficulty breathing, swallowing or speaking, unusual hoarseness, swelling in the mouth, face, lips, tongue or throat.
• Signs of high blood sugar such as confusion, drowsiness, unusual thirst and hunger, increased urination, flushing, rapid breathing, and fruity breath.
• Signs of a urinary tract infection, including blood in the urine, burning or painful urination, frequent or immediate urge to urinate, fever, pain in the lower abdomen or pelvis.
• Signs of high blood pressure, such as a very severe headache, or dizziness, or loss of consciousness, or blurred vision.
• Shortness of breath, sudden weight gain, or swelling of the arms or legs.
• Increased or abnormal heart rhythm.
• Dizziness or fainting.
• Feeling extremely tired or weak.
• Violation of motor functions.
• Muscle weakness.
• In rare cases, the use of this drug was accompanied by a very serious disorder of the pituitary gland (pituitary apoplexy). In most cases, this disorder developed 2 weeks after the first dose. If you experience sudden headaches, vomiting, fainting, mood changes, eye weakness, eye movement, or blurred vision, call your doctor right away.
• Men have been shown to have an increased risk of stroke or serious and sometimes deadly heart problems when using similar drugs. This is unlikely, but seek immediate medical attention if you have chest pain or angina, weakness on 1 side of the body, difficulty speaking or thinking, balance problems, drooping of 1 side of the face, or changes in vision.

What are some other side effects of this drug?

Any medicine can have side effects. However, for many people, side effects are either minor or non-existent. Contact your doctor or seek medical attention if these or any other side effects bother you or do not go away:

• Inability to achieve or maintain an erection.
• Headache.
• Tides.
• Sleep disorders.
• Pain in the back, muscles or joints.
• Flu-like symptoms.
• Pain at the injection site.

This list of possible side effects is not exhaustive. If you have any questions about side effects, please contact your doctor. Talk to your doctor about side effects.

You can report side effects to the National Health Board.

You can report side effects to the FDA at 1-800-332-1088. You can also report side effects at https://www.fda.gov/medwatch.

What is the best way to take this drug?

Use this drug as directed by your doctor. Read all the information provided to you. Strictly follow all instructions.

• For intramuscular injections.

What if I miss a dose of a drug?

• See your doctor for further instructions.

How do I store and/or discard this drug?

• If you need to store this drug at home, check with your doctor, nurse, or pharmacist for storage conditions.

General information about medicines

• If your health does not improve or even worsens, see your doctor.
• Do not give your medicine to anyone and do not take other people’s medicines.
• Keep all medicines in a safe place. Keep all medicines out of the reach of children and pets.
• Dispose of unused or expired drugs. Do not empty into a toilet or sewer unless instructed to do so. If you have any questions about disposing of medicines, ask your pharmacist. Drug disposal programs may be in place in your area.
• Some medicines may come with other patient information leaflets. If you have questions about this drug, talk with your doctor, nurse, pharmacist, or other health care professional.
• Some medicines may come with other patient information leaflets. Check with your pharmacist. If you have questions about this drug, talk with your doctor, nurse, pharmacist, or other health care professional.
• If you think you have overdosed, call a poison control center or get medical help right away. Be prepared to tell or show what drug you took, how much, and when it happened.

Consumer Use of Information and Limitation of Liability

This summary information includes a summary of the diagnosis, treatment, and/or drug product. It is not intended to be a comprehensive source of data and should be used as a tool to help the user understand and/or evaluate potential diagnostic and treatment options. It does NOT include all information about conditions, treatments, medications, side effects, or risks that may apply to a particular patient. It should not be considered medical advice or a substitute for medical advice, diagnosis or treatment provided by a physician based on a medical examination and assessment of the patient’s specific and unique circumstances. Patients should consult with their physician for full information about their health, medical issues, and treatment options, including any risks or benefits regarding the use of medications. This information is not a guarantee that a treatment or drug is safe, effective, or approved for a particular patient. UpToDate, Inc. and its subsidiaries disclaim any warranties or liabilities related to this information or its use. The use of this information is subject to the Terms of Use found at https://www. wolterskluwer.com/en/know/clinical-effectiveness-terms.

Last revision date

2023-02-14

Copyright

© UpToDate, Inc. and its affiliates and/or licensors, 2023. All rights reserved.

Date last updated

Monday, December 12, 2022

Triptorelin – description of the substance, pharmacology, use, contraindications, formula

Contents

• Structural formula

• Russian name

• English title

• Latin name

• chemical name

• Gross formula

• Pharmacological group of substance Triptorelin

• Nosological classification

• CAS code

• pharmachologic effect

• Characteristic

• Pharmacology

• The use of the substance Triptorelin

• Contraindications

• Application restrictions

• Use during pregnancy and lactation

• Side effects of Triptorelin

• Overdose

• Dosage and administration

• Precautionary measures

• Trade names with the active substance Triptorelin

Structural formula

Russian name

Triptorelin

English name

Triptorelin

Latin name

Triptorelin ( genus 90 244 Triptorelini)

Chemical name

D-tryptophan-6-gonadorelin acetate

Gross formula

C ₆₄ H ₈₂ N ₁₈ O ₁₃

Pharmacological group of substance Triptorelin

Hormones of the hypothalamus, pituitary gland, gonadotropins and their antagonists

Anticancer hormonal agents and hormone antagonists

Nosological classification

ICD-10 code list

• C61 Malignant neoplasm of prostate

• D25. 9 Uterine leiomyoma, unspecified

• E30.1 Precocious puberty

• N80 Endometriosis

• N91.2 Amenorrhea, unspecified

• Z31. 1 Artificial insemination

CAS code

57773-63-4

Pharmacological action

Pharmacological action –

antigonadotropic , antitumor , cytostatic .

Description

Anticancer hormonal agent, synthetic analog of gonadotropin releasing hormone (GnRH).

Pharmacology

Stimulates the release of the anterior pituitary gland LH and FSH when used initially or intermittently. In this regard, in the first few days of therapy, a transient increase in the level of estrogen and testosterone is noted. Subsequently, it blocks the release of gonadotropic hormones by the pituitary gland – LH, FSH, reduces the content of androgens and estrogens in the blood. Triptorelin is more active than the natural hormone. The maximum effect develops at 3-4 weeks (the incretion of gonadotropins – LH and FSH completely stops, estrogen production by the ovaries decreases to the level of menopause, androgen production – to the post-castration state). After cessation of treatment, the physiological secretion of hormones is restored.

Carcinogenicity, mutagenicity, effects on fertility

No adverse effects on fertility or general reproductive ability in rats were observed at daily doses in excess of the recommended human therapeutic dose (based on body surface area) of 0.2; 2 and 16 times, or 20 mcg/kg. In addition, no side effects were noted in the F ₁ generation of offspring. Studies evaluating the effect of triptorelin on fertility in male rats have not been conducted.

Depo-form gradually releases triptorelin from the surface of microcapsules and maintains a therapeutic blood concentration (200–500 ng/ml) for 30 days after a single dose. Bioavailability with intramuscular injection – 38.8%, with s / c – 69%. max “> T _max after s / c injection – 1 hour. After iv administration of 0.5 mg of triptorelin, the apparent volume of distribution in healthy male volunteers is 30-33 liters. Does not bind to plasma proteins. Metabolism of triptorelin in humans unknown, no metabolites identified Total plasma Cl (162 ml/min) consists of fast and slow components Eliminated 3 times slower than natural gonadotropin releasing hormone (low biotransformation rate) After intravenous administration of 0.5 mg triptorelin in men with normal kidney function (Cl creatinine 150 ml / min) T _1/2 – 2.81 h, with Cl creatinine 40 ml / min – 6.56 h, with Cl creatinine 9 ml / min – 7.65 h. In men with impaired liver function and an average Cl creatinine 90 ml / min min — 7.58 hours

Use of the substance Triptorelin

Endometriosis (laparoscopically confirmed if there is indication for ovarian suppression and no need for surgery), uterine fibroids (to reduce size before surgical removal), symptomatic treatment of advanced hormone-dependent prostate cancer (an alternative to surgical castration, to suppress testosterone secretion), early puberty, in vitro fertilization program, hypogonadotropic amenorrhea.

Contraindications

Hypersensitivity (including to other GnRH analogues), in men – hormone-independent prostate cancer, condition after prostatectomy, spinal metastases or urinary tract obstruction; in women – osteoporosis (increased risk of development or clinical manifestations).

Restrictions on the use of

Polycystic ovaries (when used in the IVF program).

Use in pregnancy and lactation

Contraindicated in pregnancy (no adequate and well-controlled studies have been conducted) and during breastfeeding (it is not known whether triptorelin passes into breast milk).

Triptorelin has been shown to be maternally toxic and exhibit embryotoxic properties when administered to rats at doses in excess of those recommended for humans (in terms of body surface area) of 0.2; 0.8 and 8 times. Fetotoxic and teratogenic properties have not been recorded.

In women of childbearing age, pregnancy must be excluded before starting therapy. Women during the treatment period should use non-hormonal methods for contraception.

Side effects of the substance Triptorelin

From the side of the nervous system and sensory organs: headache, sleep disturbance, mood lability, irritability, depression, asthenia, fatigue, paresthesia, visual impairment.

From the digestive tract: nausea, constipation or diarrhea, anorexia, weight gain, increased liver transaminase activity, hypercholesterolemia.

From the genitourinary system: symptoms associated with a decrease in the level of sex hormones in the blood, incl. in men – flushing to the face, decreased libido, impotence, reduced testicle size, gynecomastia; in women – “spotting” discharge or dryness of the vaginal mucosa, decreased libido, pain during intercourse, flushing of the face with profuse sweating.

On the part of the musculoskeletal system: myalgia, back pain, demineralization of bone tissue.

Allergic reactions: skin rash, hyperemia, itching at the injection site, anaphylactic shock, anaphylactoid reactions.

Other: temporary increase in symptoms (including arthralgia, progression of hematuria or urination disorders), transient hypertension, anemia, swelling of the legs.

Overdose

In case of overdose, triptorelin treatment should be discontinued immediately and appropriate symptomatic therapy instituted.

Dosage and administration

S/C, 1 time per day. Initial dose – 0.5 mg / day (for 7 days), maintenance dose – 0.1 mg / day (starting from the 8th day).

In the in vitro fertilization program, one IM injection per stimulation cycle is sufficient.

Depot forms: IM, s.c., 3.75 mg every 28 days (for women, starting from the 3rd day of menstruation), for no more than 6 months.

Precautions

During the course, it is mandatory to monitor the plasma level of sex hormones (in men and women), the concentration of PSA (prostate-specific antigen) in men, using ultrasound – the size of the fibroids (a rapid decrease in the volume of the uterus compared to the size of the fibroids can cause bleeding and sepsis).