Vilazodone interactions. Vilazodone (Viibryd): Uses, Interactions, and Important Information

11.03.202316.07.2023 by alexxlab

What is vilazodone and how does it treat depression. What are the most important things to know about taking vilazodone. How should vilazodone be taken and what happens if you miss a dose. What precautions should be taken when using vilazodone.

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Understanding Vilazodone: An Antidepressant for Major Depressive Disorder

Vilazodone, sold under the brand name Viibryd, is an antidepressant medication primarily used to treat major depressive disorder (MDD). As a selective serotonin reuptake inhibitor (SSRI) and partial serotonin 1A receptor agonist, vilazodone works in the brain to alleviate symptoms of depression.

Vilazodone is available in tablet form, with dosages of 10 mg, 20 mg, and 40 mg. The medication is typically prescribed to adults experiencing symptoms of MDD, which may include:

Persistent feelings of sadness, emptiness, or tearfulness
Feelings of worthlessness, guilt, hopelessness, and helplessness
Loss of interest or pleasure in usual activities
Changes in sleep patterns and appetite
Low energy and difficulty concentrating
Thoughts of death or suicidal ideation
Psychomotor agitation or retardation

Key Considerations When Taking Vilazodone

When prescribed vilazodone, there are several important factors to keep in mind:

Do not stop taking vilazodone abruptly, even if you start feeling better
Consult your healthcare provider to determine the appropriate duration of treatment
Missing doses may increase the risk of symptom relapse
Sudden discontinuation can lead to withdrawal symptoms
Be aware of the potential for manic episodes in individuals with bipolar disorder
Seek medical attention if signs of serotonin syndrome appear

Can vilazodone be safely used during pregnancy? It’s crucial to discuss the risks and benefits with your healthcare provider if you’re planning to become pregnant or are currently pregnant. Untreated depression can pose risks to both the mother and fetus, so a careful evaluation of treatment options is necessary. Caution is also advised for breastfeeding mothers, as vilazodone can pass into breast milk.

Proper Administration and Dosage of Vilazodone

To ensure the most effective treatment with vilazodone, follow these guidelines:

Take vilazodone once daily with food or milk
Start with a low dose, which will be gradually increased over several weeks
The typical dose range is 20 mg to 40 mg, as determined by your healthcare provider
Use reminders like calendars, pillboxes, or phone alerts to maintain a consistent medication schedule

Is it okay to miss a dose of vilazodone? If you miss a dose, take it as soon as you remember, unless it’s close to the time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Never double up on doses to make up for a missed one.

Potential Interactions and Precautions with Vilazodone

When taking vilazodone, it’s important to be aware of potential interactions and take necessary precautions:

Avoid alcohol consumption and illegal drug use while on vilazodone
Inform your healthcare provider about all medications, supplements, and herbal products you’re taking
Be cautious about activities requiring mental alertness until you know how vilazodone affects you
Monitor for signs of increased suicidal thoughts, especially in young adults and adolescents

How does vilazodone interact with other medications? Vilazodone may interact with various drugs, including other antidepressants, triptans, certain pain medications, and some herbal supplements. Always consult your healthcare provider or pharmacist before starting any new medication or supplement while taking vilazodone.

Recognizing and Managing Side Effects of Vilazodone

Like all medications, vilazodone can cause side effects. Common side effects may include:

Diarrhea
Nausea
Vomiting
Insomnia
Dizziness
Dry mouth
Sexual dysfunction

What should you do if you experience side effects from vilazodone? If you experience any side effects, discuss them with your healthcare provider. Some side effects may subside as your body adjusts to the medication, while others may require adjustments to your treatment plan.

Serious Side Effects Requiring Immediate Attention

While rare, some side effects of vilazodone require immediate medical attention:

Signs of serotonin syndrome (high fever, agitation, hallucinations, severe dizziness, rapid heartbeat)
Severe allergic reactions
Unusual bleeding or bruising
Seizures
Changes in heart rhythm

Vilazodone and Its Impact on Daily Life

Taking vilazodone may affect various aspects of your daily life:

Work performance: Initially, you may experience drowsiness or difficulty concentrating
Driving and operating machinery: Exercise caution until you know how vilazodone affects you
Social interactions: Mood improvements may positively impact your social life
Physical activity: Be aware of potential dizziness or balance issues

How long does it take for vilazodone to start working? While some improvement in sleep, appetite, and energy levels may be noticed within 1-2 weeks, it typically takes 4-6 weeks to experience the full antidepressant effects of vilazodone.

Long-term Use and Monitoring of Vilazodone Treatment

For effective long-term treatment with vilazodone:

Attend regular follow-up appointments with your healthcare provider
Report any changes in symptoms or new side effects
Discuss any concerns about long-term use or desire to discontinue treatment
Be prepared for periodic reassessment of your medication dosage and overall treatment plan

Is it necessary to take vilazodone indefinitely? The duration of vilazodone treatment varies for each individual. Some people may need to take it for extended periods, while others may be able to discontinue use after a certain time. Always consult your healthcare provider before making any changes to your medication regimen.

Vilazodone vs. Other Antidepressants: Comparative Analysis

Vilazodone belongs to a unique class of antidepressants that combines SSRI properties with partial agonism of the serotonin 1A receptor. This dual mechanism of action sets it apart from traditional SSRIs and may offer potential benefits for some patients.

Compared to other antidepressants, vilazodone may have:

A lower risk of weight gain
Potentially fewer sexual side effects
A unique side effect profile that may be more tolerable for some individuals

However, the effectiveness of vilazodone compared to other antidepressants can vary from person to person. Your healthcare provider will consider your specific symptoms, medical history, and potential side effects when determining the most appropriate antidepressant for you.

Switching from Another Antidepressant to Vilazodone

If you’re considering switching from another antidepressant to vilazodone, it’s crucial to do so under the guidance of your healthcare provider. The process may involve:

Gradually tapering off your current medication
A washout period, if necessary
Slowly introducing vilazodone at a low dose and increasing over time
Close monitoring for any adverse effects or withdrawal symptoms

How can you minimize withdrawal symptoms when switching to vilazodone? Your healthcare provider may recommend a cross-tapering approach, where vilazodone is gradually introduced while your current antidepressant is slowly decreased. This method can help minimize withdrawal symptoms and ensure a smooth transition between medications.

Lifestyle Modifications to Enhance Vilazodone Treatment

While vilazodone can be an effective treatment for depression, combining medication with lifestyle changes can often lead to better outcomes. Consider incorporating the following strategies to support your mental health:

Regular exercise: Aim for at least 30 minutes of moderate activity most days of the week
Healthy diet: Focus on whole foods, fruits, vegetables, and lean proteins
Adequate sleep: Maintain a consistent sleep schedule and practice good sleep hygiene
Stress management: Learn and practice relaxation techniques such as meditation or deep breathing exercises
Social connections: Nurture relationships with friends and family, and consider joining support groups
Therapy: Cognitive-behavioral therapy (CBT) or other forms of psychotherapy can complement medication treatment

How can these lifestyle changes improve the effectiveness of vilazodone? By adopting healthy habits, you may experience enhanced mood stability, reduced stress, and improved overall well-being, which can work synergistically with vilazodone to alleviate depressive symptoms more effectively.

Mindfulness and Meditation Practices

Incorporating mindfulness and meditation into your daily routine can be particularly beneficial when taking vilazodone. These practices can help:

Reduce anxiety and stress
Improve emotional regulation
Enhance self-awareness
Promote better sleep quality

Consider starting with short, guided meditation sessions and gradually increase the duration as you become more comfortable with the practice.

Managing Expectations and Tracking Progress with Vilazodone

When starting vilazodone treatment, it’s important to have realistic expectations and a system for tracking your progress. This can help you and your healthcare provider make informed decisions about your treatment plan.

Consider the following strategies:

Keep a mood journal to record daily emotions, energy levels, and any side effects
Use a symptom tracking app to monitor changes in depressive symptoms over time
Set small, achievable goals and celebrate progress
Communicate regularly with your healthcare provider about your experiences

How can tracking your progress help optimize vilazodone treatment? By consistently monitoring your symptoms and side effects, you and your healthcare provider can make timely adjustments to your treatment plan, ensuring the most effective management of your depression.

Recognizing Treatment Response and Remission

Understanding the concepts of treatment response and remission can help you set appropriate expectations for your vilazodone treatment:

Treatment response: Generally defined as a 50% or greater reduction in depressive symptoms
Remission: Minimal or no symptoms of depression for a sustained period

It’s important to note that achieving remission may take time and might require adjustments to your treatment plan. Maintain open communication with your healthcare provider throughout the process.

Vilazodone and Special Populations: Considerations and Adaptations

While vilazodone is primarily prescribed for adults with major depressive disorder, special considerations may be necessary for certain populations:

Elderly Patients

Older adults may be more sensitive to the effects of vilazodone and may require dose adjustments. Factors to consider include:

Increased risk of falls due to dizziness or balance issues
Potential interactions with other medications commonly used by older adults
Changes in metabolism and kidney function that may affect drug processing

Patients with Liver or Kidney Impairment

Individuals with liver or kidney problems may require special monitoring and dose adjustments when taking vilazodone. Your healthcare provider will assess your organ function and adjust the treatment plan accordingly.

Adolescents and Young Adults

While vilazodone is not FDA-approved for use in individuals under 18, it may sometimes be prescribed off-label for adolescents. Special considerations for this age group include:

Increased risk of suicidal thoughts and behaviors
Potential impact on growth and development
Need for close monitoring and frequent follow-ups

How should treatment be adapted for these special populations? Your healthcare provider will consider factors such as age, overall health status, and potential drug interactions when developing a personalized treatment plan. This may involve starting at lower doses, more frequent monitoring, or alternative treatment options when necessary.

Future Directions in Depression Treatment: Beyond Vilazodone

While vilazodone represents an important option in the current landscape of antidepressant medications, ongoing research continues to explore new avenues for treating depression. Some promising areas of investigation include:

Ketamine and esketamine: Rapid-acting antidepressants for treatment-resistant depression
Psychedelic-assisted therapy: Exploring the potential of substances like psilocybin in combination with psychotherapy
Personalized medicine approaches: Using genetic testing and biomarkers to tailor treatment plans
Digital therapeutics: Leveraging technology to deliver cognitive behavioral therapy and other interventions
Neuromodulation techniques: Advancements in treatments like transcranial magnetic stimulation (TMS)

What role might vilazodone play in future treatment paradigms? As our understanding of depression and its underlying mechanisms continues to evolve, vilazodone may be used in combination with newer therapies or as part of more personalized treatment approaches based on individual patient characteristics.

The Importance of Ongoing Research and Clinical Trials

Participating in clinical trials can provide access to cutting-edge treatments and contribute to the advancement of depression care. If you’re interested in exploring new treatment options, consider:

Discussing clinical trial opportunities with your healthcare provider
Checking reputable sources like ClinicalTrials.gov for ongoing studies
Understanding the potential risks and benefits of participating in research

By staying informed about developments in depression treatment and working closely with your healthcare provider, you can ensure that you’re receiving the most appropriate and effective care for your individual needs, whether that includes vilazodone or other emerging therapies.

Vilazodone (Viibryd) | NAMI: National Alliance on Mental Illness

Generic name: vilazodone (vil AZ oh done)

Brand name: Viibryd®

Tablets: 10 mg, 20 mg, 40 mg

All FDA black box warnings are at the end of this fact sheet. Please review before taking this medication.

What Is Vilazodone And What Does It Treat?

Vilazodone is an antidepressant medication that works in the brain. It is approved for the treatment of major depressive disorder (MDD).

Symptoms of depression include:

Depressed mood – feeling sad, empty, or tearful

Feeling worthless, guilty, hopeless, and helpless

Loss of interest or pleasure in your usual activities

Sleep and eat more or less than usual (for most people it is less)

Low energy, trouble concentrating, or thoughts of death (suicidal thinking)

Psychomotor agitation (‘nervous energy’)

Psychomotor retardation (feeling like you are moving and thinking in slow motion)

Suicidal thoughts or behaviors

What Is The Most Important Information I Should Know About Vilazodone?

Do not stop taking vilazodone, even when you feel better. With input from you, your health care provider will assess how long you will need to take the medicine.

Missing doses of vilazodone may increase your risk for relapse in your symptoms.

Stopping vilazodone abruptly may result in one or more of the following withdrawal symptoms: irritability, nausea, feeling dizzy, vomiting, nightmares, headache, and/or paresthesias (prickling, tingling sensation on the skin).

Depression is also a part of bipolar illness. People with bipolar disorder who take antidepressants may be at risk for “switching” from depression into mania. Symptoms of mania include “high” or irritable mood, very high self-esteem, decreased need for sleep, pressure to keep talking, racing thoughts, being easily distracted, frequently involved in activities with a large risk for bad consequences (for example, excessive buying sprees).

Medical attention should be sought if serotonin syndrome is suspected. Please refer to serious side effects for signs/symptoms.

Are There Specific Concerns About Vilazodone And Pregnancy?

If you are planning on becoming pregnant, notify your health care provider to best manage your medications. People living with MDD who wish to become pregnant face important decisions. Untreated MDD has risks to the fetus, as well as the mother. It is important to discuss the risks and benefits of treatment with your doctor and caregivers.

Caution is advised with breastfeeding since vilazodone does pass into breast milk.

What Should I Discuss With My Health Care Provider Before Taking Vilazodone?

Symptoms of your condition that bother you the most

If you have thoughts of suicide or harming yourself

Medications you have taken in the past for your condition, whether they were effective or caused any adverse effects

If you experience side effects from your medications, discuss them with your provider. Some side effects may pass with time, but others may require changes in the medication.

Any other psychiatric or medical problems you have, including a history of bipolar disorder

All other medications you are currently taking (including over the counter products, herbal and nutritional supplements) and any medication allergies you have

Other non-medication treatment you are receiving, such as talk therapy or substance abuse treatment. Your provider can explain how these different treatments work with the medication.

If you are pregnant, plan to become pregnant, or are breastfeeding

If you drink alcohol or use drugs

How Should I Take Vilazodone?

Vilazodone is usually taken one time per day with food or milk.

Typically patients begin at a low dose of medicine and the dose is increased slowly over several weeks.

The dose usually ranges from 20 mg to 40 mg. Only your health care provider can determine the correct dose for you.

Consider using a calendar, pillbox, alarm clock, or cell phone alert to help you remember to take your medication. You may also ask a family member or friend to remind you or check in with you to be sure you are taking your medication.

What Happens If I Miss A Dose Of Vilazodone?

If you miss a dose of vilazodone, take it as soon as you remember, unless it is closer to the time of your next dose. Discuss this with your health care provider. Do not double your next dose or take more than what is prescribed.

What Should I Avoid While Taking Vilazodone?

Avoid drinking alcohol or using illegal drugs while you are taking antidepressant medications. They may decrease the benefits (e.g., worsen your condition) and increase adverse effects (e.g., sedation) of the medication.

What Happens If I Overdose With Vilazodone?

If an overdose occurs, call your doctor or 911. You may need urgent medical care. You may also contact the poison control center at 1-800-222-1222.

A specific treatment to reverse the effects of vilazodone does not exist.

What Are The Possible Side Effects Of Vilazodone?

Common side effects

Diarrhea, nausea, vomiting, dry mouth, dizziness, insomnia

Rare/serious side effects

Night sweats, decreased appetite, migraine headaches, sleepiness, tremor, blurry vision, dry eyes, abnormal dreams, agitation, restlessness, increased urination, sexual dysfunction, angle closure glaucoma (symptoms of angle closure glaucoma may include eye pain, changes in vision, swelling or redness in or around eye), Serotonin syndrome (symptoms may include shivering, diarrhea, confusion, severe muscle tightness, fever, seizures, and death), palpitations, irregular heartbeat

Vilazodone may increase the risk of bleeding events. Combined use of aspirin, nonsteroidal anti-inflammatory drugs (e.g., ibuprofen, naproxen), warfarin, and other anti-coagulants may increase this risk. This may include gums that bleed more easily, nose bleed, or gastrointestinal bleeding. Some cases have been life threatening.

Are There Any Risks For Taking Vilazodone For Long Periods Of Time?

To date, there are no known problems associated with long term use of vilazodone. It is a safe and effective medication when used as directed.

What Other Medications May Interact With Vilazodone?

Vilazodone should not be taken with or within 2 weeks of taking monoamine oxidase inhibitors (MAOIs). These include phenelzine (Nardil®), tranylcypromine (Parnate®), isocarboxazid (Marplan®), rasagiline (Azalect®) and selegiline (Emsam®).

Although rare, there is an increased risk of serotonin syndrome when vilazodone is used with other medications that increase serotonin, such as other antidepressants, migraine medications called “triptans” (e. g., Imitrex®), some pain medications (e.g., tramadol (Ultram®), and the antibiotic linezolid (Zyvox®).

The following medications may increase the levels and effects of vilazodone requiring decreased dose of vilazodone:

Antibiotics, such as clarithromycin (Biaxin®), erythromycin (Ery-Tab®), and telithromycin (Ketek®)

Antifungals, such as fluconazole (Diflucan®), ketoconazole (Nizoral®), and itraconazole (Sporanox®)

Blood pressure medications, such as verapamil (Calan®, Covera-HS®, Isoptin SR®) and diltiazem (Cardizem®, Tiazac®)

HIV medications such as protease inhibitors: indinavir (Crixivan®), ritonavir (Norvir®), saquinavir (Fortovase®, Invirase®), and lopinavir/ritonavir (Kaletra®)

Nefazodone

The following medications may decrease the levels and effects of vilazodone requiring increased dose of vilazodone: carbamazepine (Tegretol®), oxcarbazepine (Trileptal®), rifampin (Rifadin®), phenytoin (Dilantin®), and phenobarbital

How Long Does It Take For Vilazodone To Work?

Sleep, energy, or appetite may show some improvement within the first 1-2 weeks. Improvement in these physical symptoms can be an important early signal that the medication is working. Depressed mood and lack of interest in activities may need up to 6-8 weeks to fully improve.

Summary of FDA Black Box Warnings

Suicidal thoughts or actions in children and adults

Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients with major depressive disorder (MDD), both adult and pediatric, may experience worsening of their depression and/or the emergence of suicidal ideation and behavior (suicidality) or unusual changes in behavior, whether or not they are taking antidepressant medications. This risk may persist until significant remission occurs.

In short-term studies, antidepressants increased the risk of suicidality in children, adolescents, and young adults when compared to placebo. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24. Adults age 65 and older taking antidepressants have a decreased risk of suicidality. Patients, their families, and caregivers should be alert to the emergence of anxiety, restlessness, irritability, aggressiveness and insomnia. If these symptoms emerge, they should be reported to the patient’s prescriber or health care professional. All patients being treated with antidepressants for any indication should watch for and notify their health care provider for worsening symptoms, suicidality and unusual changes in behavior, especially during the first few months of treatment.

Provided by

(January 2023)

©2020 The American Association of Psychiatric Pharmacists (AAPP) and the National Alliance on Mental Illness (NAMI). AAPP and NAMI make this document available under the Creative Commons Attribution-No Derivatives 4.0 International License. Last Updated: January 2016.

This information is being provided as a community outreach effort of the American Association of Psychiatric Pharmacists. This information is for educational and informational purposes only and is not medical advice. This information contains a summary of important points and is not an exhaustive review of information about the medication. Always seek the advice of a physician or other qualified medical professional with any questions you may have regarding medications or medical conditions. Never delay seeking professional medical advice or disregard medical professional advice as a result of any information provided herein. The American Association of Psychiatric Pharmacists disclaims any and all liability alleged as a result of the information provided herein.

Vilazodone Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Warnings:

Antidepressant medications are used to treat a variety of conditions, including depression and other mental/mood disorders. These medications can help prevent suicidal thoughts/attempts and provide other important benefits. However, studies have shown that a small number of people (especially people younger than 25) who take antidepressants for any condition may experience worsening depression, other mental/mood symptoms, or suicidal thoughts/attempts. It is very important to talk with the doctor about the risks and benefits of antidepressant medication (especially for people younger than 25), even if treatment is not for a mental/mood condition.

Tell the doctor right away if you notice worsening depression/other psychiatric conditions, unusual behavior changes (including possible suicidal thoughts/attempts), or other mental/mood changes (including new/worsening anxiety, panic attacks, trouble sleeping, irritability, hostile/angry feelings, impulsive actions, severe restlessness, very rapid speech). Be especially watchful for these symptoms when a new antidepressant is started or when the dose is changed.

Warnings:

Uses

Vilazodone is used to treat depression. It is an SSRI (selective serotonin reuptake inhibitor) and partial serotonin receptor agonist. It works by helping to restore the balance of certain natural substances in the brain (neurotransmitters such as serotonin). This medication may improve your mood, sleep, appetite, and energy level and may help restore your interest in daily living.

How to use Vilazodone 40 Mg Tablet Antidepressant Selective Serotonin Reuptake Inhib. (Ssris)

Read the Medication Guide provided by your pharmacist before you start taking vilazodone and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with food as directed by your doctor, usually once daily. The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

To reduce your risk of side effects, your doctor may start you at a low dose and gradually increase your dose. Follow your doctor’s instructions carefully. Do not take more or less medication or take it more often than prescribed. Your condition will not improve any faster and your risk of side effects will increase.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.

If you suddenly stop using this medication, you may have withdrawal symptoms (such as mood swings, headache, tiredness, sleep changes, ringing in the ears, seizures, numbness/tingling, “shock-like” feelings). To help prevent withdrawal, your doctor may lower your dose slowly. Withdrawal is more likely if you have used vilazodone for a long time or in high doses. Tell your doctor or pharmacist right away if you have withdrawal.

Tell your doctor if your condition lasts or gets worse.

Side Effects

Precautions

Before taking vilazodone, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: personal or family history of bipolar/manic-depressive disorder, personal or family history of suicide attempts, intestinal ulcers/bleeding (peptic ulcer disease), seizures, personal or family history of glaucoma (angle-closure type).

This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Older adults may be more sensitive to the side effects of this drug, especially bleeding. They are also more likely to develop a salt imbalance (hyponatremia), especially if they are also taking “water pills” (diuretics) with this medication. Salt imbalance can increase the risk of falling.

During pregnancy, this medication should be used only when clearly needed. It may harm an unborn baby. Also, babies born to mothers who have used this drug during the last 3 months of pregnancy may rarely develop withdrawal symptoms such as feeding/breathing difficulties, seizures, muscle stiffness, or constant crying. If you notice any of these symptoms in your newborn, tell the doctor promptly.

Since untreated mental/mood problems (such as depression) can be a serious condition, do not stop taking this medication unless directed by your doctor. If you are planning pregnancy, become pregnant, or think you may be pregnant, immediately discuss with your doctor the benefits and risks of using this medication during pregnancy.

It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Some products that may interact with this drug are: other drugs that can cause bleeding/bruising (including antiplatelet drugs such as clopidogrel, NSAIDs such as ibuprofen/naproxen, “blood thinners” such as dabigatran/warfarin).

Aspirin can increase the risk of bleeding when used with this medication. However, if your doctor has directed you to take low-dose aspirin for heart attack or stroke prevention (usually 81-162 milligrams a day), you should continue taking it unless your doctor instructs you otherwise. Ask your doctor or pharmacist for more details.

Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Avoid taking MAO inhibitors (isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before and after treatment with this medication. Ask your doctor when to start or stop taking this medication.

The risk of serotonin syndrome/toxicity increases if you are also taking other drugs that increase serotonin. Examples include street drugs such as MDMA/”ecstasy,” St. John’s wort, certain antidepressants (including other SSRIs such as fluoxetine/paroxetine, SNRIs such as duloxetine/venlafaxine), tryptophan, among others. The risk of serotonin syndrome/toxicity may be more likely when you start or increase the dose of these drugs.

This medication may interfere with certain medical/lab tests (such as brain scan for Parkinson’s disease), possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug.

Does Vilazodone 40 Mg Tablet Antidepressant Selective Serotonin Reuptake Inhib. (Ssris) interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Do not share this medication with others.

Keep all regular medical and psychiatric appointments. Medical/psychiatric check-ups should be done periodically to monitor your progress or check for side effects. Consult your doctor for more details.

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.