What are the common side effects of Lipitor. How can you manage potential risks associated with atorvastatin. Is weight gain a concern for Lipitor users. What should you know about Lipitor’s impact on muscle health.

Common Side Effects of Lipitor: What to Expect

Lipitor, also known by its generic name atorvastatin, is a widely prescribed medication for treating high cholesterol and reducing heart disease risks. While it’s generally well-tolerated, understanding its potential side effects is crucial for patients. Here are some of the most common side effects reported:

• Infections (e.g., common cold, urinary tract infections)
• Pain in arms or legs
• Nausea
• Joint pain
• Diarrhea
• Mild muscle pain

These side effects are typically mild and often resolve on their own. However, if they persist or become bothersome, it’s important to consult with your healthcare provider.

Serious Side Effects: When to Seek Medical Attention

While less common, Lipitor can occasionally cause more severe side effects that require immediate medical attention. These include:

• Severe muscle pain
• Rhabdomyolysis (breakdown of muscle tissue)
• Immune-mediated necrotizing myopathy (a rare muscle condition)
• Liver damage
• Severe allergic reactions

If you experience any of these symptoms, it’s crucial to contact your doctor immediately or seek emergency medical care if the symptoms appear life-threatening.

Managing Lipitor’s Impact on Muscle Health

Muscle-related side effects are among the most concerning for Lipitor users. How can patients mitigate these risks? Here are some strategies:

1. Regular monitoring: Schedule routine check-ups to assess muscle enzyme levels.
2. Stay hydrated: Proper hydration can help reduce the risk of muscle problems.
3. Exercise cautiously: While physical activity is beneficial, start slowly and gradually increase intensity.
4. Report symptoms promptly: Inform your doctor about any unexplained muscle pain, tenderness, or weakness.

By staying vigilant and proactive, patients can better manage the potential impact of Lipitor on muscle health.

Lipitor and Liver Health: What You Need to Know

Lipitor’s effect on the liver is a concern for many patients. How does this medication interact with liver function? Lipitor is processed by the liver, and in rare cases, it can cause liver damage. Here’s what patients should be aware of:

• Regular liver function tests are typically recommended, especially during the first year of treatment.
• Symptoms of liver problems may include unexplained fatigue, loss of appetite, dark urine, or yellowing of the skin or eyes.
• Patients with pre-existing liver conditions should discuss the risks and benefits of Lipitor with their healthcare provider.

Monitoring liver health is an essential aspect of Lipitor treatment, ensuring the medication’s benefits outweigh potential risks.

Lipitor and Weight: Debunking the Weight Gain Myth

Is weight gain a side effect of Lipitor? This is a common concern among patients. However, clinical studies have not shown a direct link between Lipitor use and weight gain. In fact, some research suggests that statins like Lipitor may have a slight weight loss effect in some individuals.

If you notice weight changes while taking Lipitor, consider these factors:

• Dietary changes: Often, patients modify their diet when starting cholesterol medication, which can affect weight.
• Lifestyle factors: Changes in physical activity or other medications can influence weight.
• Individual variations: Each person’s body may respond differently to medication.

If you’re concerned about weight changes while on Lipitor, discuss this with your healthcare provider. They can help determine if the medication is a contributing factor or if other lifestyle adjustments are needed.

Navigating Lipitor’s Impact on Daily Life

How does Lipitor affect everyday activities and quality of life? While many patients experience no significant disruptions, others may need to make some adjustments:

• Timing of medication: Taking Lipitor at the same time each day can help minimize side effects.
• Alcohol consumption: Moderate alcohol intake is generally safe, but excessive drinking can increase the risk of liver problems.
• Grapefruit interactions: Grapefruit and grapefruit juice can interact with Lipitor, potentially increasing side effects.
• Sun sensitivity: Some patients may experience increased sensitivity to sunlight.

By being aware of these potential impacts, patients can better integrate Lipitor into their daily routines while minimizing disruptions.

Lipitor and Other Medications: Managing Interactions

How does Lipitor interact with other medications? Understanding potential drug interactions is crucial for patient safety. Some medications that may interact with Lipitor include:

• Certain antibiotics
• Some antifungal medications
• Other cholesterol-lowering drugs
• Certain HIV medications

To minimize the risk of interactions:

1. Inform your healthcare provider about all medications, supplements, and herbal products you’re taking.
2. Be particularly cautious with medications that affect liver function.
3. Follow dosing instructions carefully, especially if you’re prescribed multiple medications.

Your healthcare provider can help manage potential interactions and adjust your treatment plan if necessary.

Special Considerations for Elderly Patients on Lipitor

How does age affect the side effect profile of Lipitor? Elderly patients may be more susceptible to certain side effects due to changes in metabolism and potential interactions with other medications. Key considerations include:

• Increased risk of muscle-related side effects
• Potential for drug interactions due to multiple medications
• Need for more frequent monitoring of liver and kidney function

Healthcare providers often start elderly patients on lower doses of Lipitor and monitor them more closely for side effects.

Long-term Use of Lipitor: What to Expect

What are the implications of taking Lipitor for extended periods? Long-term use of Lipitor is common for managing chronic high cholesterol. Here’s what patients should know:

• Continued effectiveness: Lipitor typically maintains its cholesterol-lowering effects over time.
• Ongoing monitoring: Regular check-ups and blood tests are important to ensure the medication remains safe and effective.
• Potential for dose adjustments: Your doctor may need to adjust your dose based on your response and any side effects.

Long-term users of Lipitor should maintain open communication with their healthcare providers to address any concerns that arise over time.

Managing Side Effects: Practical Tips for Lipitor Users

How can patients effectively manage side effects while taking Lipitor? Here are some practical strategies:

1. Keep a symptom diary: Track any side effects and their severity to discuss with your doctor.
2. Stay active: Regular, moderate exercise can help mitigate muscle-related side effects.
3. Maintain a balanced diet: A healthy diet can complement Lipitor’s effects and may help reduce side effects.
4. Consider timing: Taking Lipitor in the evening may help reduce certain side effects for some patients.
5. Don’t skip doses: Consistent use is important for Lipitor’s effectiveness.

Remember, never stop taking Lipitor or adjust your dose without consulting your healthcare provider.

Alternative Options: When Lipitor Isn’t the Right Fit

What options are available if Lipitor’s side effects are too severe? While Lipitor is effective for many, it’s not the only option for managing high cholesterol. Alternatives may include:

• Other statins with different side effect profiles
• Non-statin cholesterol medications
• Combination therapies
• Intensive lifestyle modifications

Your healthcare provider can help determine the best alternative if Lipitor isn’t suitable for you, considering your overall health profile and risk factors.

The Role of Diet and Exercise in Complementing Lipitor Treatment

How can lifestyle changes enhance the effectiveness of Lipitor and potentially reduce side effects? A holistic approach to cholesterol management can include:

• Adopting a heart-healthy diet rich in fruits, vegetables, and whole grains
• Engaging in regular physical activity
• Maintaining a healthy weight
• Limiting alcohol consumption
• Quitting smoking

These lifestyle modifications can work synergistically with Lipitor to improve overall cardiovascular health and may help minimize the need for higher medication doses.

Monitoring and Follow-up: Ensuring Safe Long-term Use of Lipitor

How often should patients on Lipitor be monitored? Regular follow-ups are crucial for safe and effective long-term use of Lipitor. A typical monitoring schedule may include:

• Initial follow-up: 4-12 weeks after starting treatment
• Lipid profile checks: Every 3-12 months, depending on individual factors
• Liver function tests: Initially and as needed based on risk factors
• Muscle enzyme tests: As needed, especially if muscle symptoms occur

Your healthcare provider will determine the most appropriate monitoring schedule based on your individual health profile and response to the medication.

Recognizing and Reporting Adverse Effects

How can patients effectively communicate side effects to their healthcare providers? Being proactive in recognizing and reporting side effects is crucial. Here’s what to keep in mind:

• Be specific about symptoms, including onset, duration, and severity
• Report any new symptoms, even if they seem unrelated to Lipitor
• Don’t hesitate to contact your healthcare provider between scheduled appointments if concerning symptoms arise
• Consider using a symptom tracking app or journal to provide detailed information to your doctor

Clear communication about side effects helps your healthcare provider make informed decisions about your treatment plan.

Understanding the Benefits vs. Risks of Lipitor Treatment

How do the potential side effects of Lipitor compare to its benefits? While side effects are a concern, it’s important to consider the overall picture:

• Lipitor significantly reduces the risk of heart attack, stroke, and other cardiovascular events in at-risk individuals
• The majority of side effects are mild and manageable
• Serious side effects are rare, and the risk can be minimized through proper monitoring and management

Your healthcare provider can help you weigh the potential risks against the proven benefits of Lipitor based on your individual health profile and risk factors.

Patient Education: Empowering Informed Decisions

How can patients become more informed about their Lipitor treatment? Education is key to managing any medication effectively. Consider these strategies:

• Ask your healthcare provider for detailed information about Lipitor and its effects
• Utilize reputable online resources for additional information
• Participate in patient support groups or forums to learn from others’ experiences
• Stay updated on new research and guidelines related to cholesterol management

An informed patient is better equipped to manage their treatment effectively and communicate with their healthcare team.

Understanding and managing the side effects of Lipitor is an ongoing process that requires collaboration between patients and healthcare providers. By staying informed, vigilant, and proactive, patients can maximize the benefits of Lipitor while minimizing potential risks. Remember, your healthcare provider is your best resource for personalized advice and guidance throughout your treatment journey.

Lipitor Side Effects and How to Manage Them

Lipitor (atorvastatin) is a prescription drug that’s used to treat high cholesterol and reduce certain heart risks. Lipitor can cause side effects, also called adverse effects, that range from mild to serious. Examples include muscle pain and liver damage.

Lipitor is used along with diet and exercise to:

• lower cholesterol levels in adults and some children
• reduce other heart risks in adults with high cholesterol

The active ingredient in Lipitor is atorvastatin. (An active ingredient is what makes a drug work.) The drug comes as a tablet that you swallow.

Keep reading to learn about the common, mild, and serious side effects that Lipitor can cause. For a general overview of the drug, including details about its uses, see this article.

Some people may experience mild to serious side effects during Lipitor treatment. Examples of Lipitor’s commonly reported side effects include:

• infections, such as the common cold or urinary tract infection (UTI)
• nausea
• pain in your arms or legs
• joint pain*
• diarrhea*

* To learn more about this side effect, see the “Side effects explained” section below.

Examples of mild side effects that have been reported with Lipitor include:

• infections, such as the common cold or urinary tract infection (UTI)
• pain in the legs or arms
• nausea
• mild muscle pain*
• joint pain*
• diarrhea*
• mild allergic reaction*

* To learn more about this side effect, see the “Side effects explained” section below.

In most cases, these side effects are temporary. And some may be easily managed. But if you have any symptoms that are ongoing or bother you, talk with your doctor or pharmacist. And, do not stop taking Lipitor unless your doctor recommends it.

Lipitor may cause mild side effects other than the ones listed above. See the drug’s prescribing information for details.

Note: After the Food and Drug Administration (FDA) approves a drug, it tracks side effects of the medication. If you’d like to notify the FDA about a side effect you’ve had with Lipitor, visit MedWatch.

Serious side effects that have been reported with Lipitor include:

• serious muscle pain
• rhabdomyolysis, a serious condition caused by the breakdown of muscle
• immune-mediated necrotizing myopathy, a rare muscle condition
• liver damage*
• severe allergic reaction*†

* To learn more about this side effect, see the “Side effects explained” section below.
† An allergic reaction is possible after using Lipitor. But it’s unclear whether this side effect occurred in studies.

If you develop serious side effects while taking Lipitor, call your doctor right away. If the side effects seem life threatening or you think you’re having a medical emergency, immediately call 911 or your local emergency number.

Get answers to some frequently asked questions about Lipitor’s side effects.

Do Lipitor and atorvastatin (generic name for Lipitor) have similar side effects?

Yes. Lipitor and its generic version, atorvastatin, typically have the same side effects. Both drugs contain the same active ingredient, which is atorvastatin. An active ingredient is what makes a drug work.

But the inactive ingredients in Lipitor and atorvastatin may be different. So it’s possible to have different side effects due to the inactive ingredients in these drugs.

If you’re interested in switching between the brand-name and generic forms of Lipitor, talk with your doctor or pharmacist. They can discuss with you possible differences in the generic’s side effects compared with Lipitor’s.

Is there any difference between the side effects Lipitor may cause in females and males?

No, Lipitor should not cause different side effects in females and males.* In studies of Lipitor, there weren’t differences in side effects in men compared with side effects in women.

It’s important to note that doctors may not prescribe Lipitor during pregnancy or breastfeeding. This is because the drug may cause other side effects while pregnant and breastfeeding. For more information, see the “Warnings for Lipitor” section below.

* In this article, we use the terms “male,” “female,” “men,” and “women” to refer to someone’s sex assigned at birth. For information about the difference between sex and gender, see this article.

Does my risk of side effects depend on what dose of Lipitor I take (10 mg, 20 mg, 40 mg, and 80 mg)?

It’s possible that the strength of Lipitor you take may change your risk of side effects. Lipitor is available in four strengths:

• 10 milligrams (mg)
• 20 mg
• 40 mg
• 80 mg

Taking a higher dose of Lipitor may increase the risk of side effects. So, if you’re taking a dose of 80 mg per day, your risk of side effects may be higher than that of someone taking a 10-mg dose.

If you’re having side effects from taking Lipitor, talk with your doctor. They can check whether your dose of Lipitor needs adjusting.

For more information about Lipitor’s dosages, see this article.

Are weight gain and hair loss side effects of Lipitor?

No, weight gain and hair loss are not side effects of Lipitor.

But there may be a link between taking statin medications such as Lipitor and an increase in appetite. An older study showed that people taking statins consumed more calories and fat than people not taking such drugs. So it is possible that this increase in appetite may lead to weight gain. But this was not reported in studies of the drug.

If you’re taking Lipitor to reduce your risk of heart problems due to type 2 diabetes, you may notice hair loss. This is because diabetes may increase the risk of hair loss in females and males.*

If you have weight gain or hair loss during your treatment with Lipitor, talk with your doctor or pharmacist. They may be able to recommend ways to manage your weight gain or hair loss.

* In this article, we use the term “female” to refer to someone’s sex assigned at birth. For information about the difference between sex and gender, see this article.

Does Lipitor cause any eye-related side effects?

Although rare, it’s possible for Lipitor to cause blurry vision. This side effect was reported in studies of Lipitor.

In addition, eye-related side effects may be a symptom of another side effect that Lipitor causes. Lipitor can increase your risk of liver problems. One side effect of liver problems is yellowing of the eyes or skin.

If you have yellowing of the eyes or other eye-related changes while you’re taking Lipitor, contact your doctor. They can find out what may be causing your eye-related side effects and the best way to treat them.

Learn more about some of the side effects Lipitor may cause.

Muscle pain

You may develop muscle pain during treatment with Lipitor. Muscle pain was a common side effect reported in studies of the drug.

This side effect can be mild or severe. In some cases, muscle pain can also be a sign of a more serious side effect. Examples include rhabdomyolysis, a condition caused by the breakdown of muscle, and immune-mediating necrotizing myopathy, a rare muscle condition.

What might help

If you have muscle pain while taking Lipitor, talk with your doctor. They can determine what may be causing it.

If your muscle pain is mild, your doctor may recommend decreasing your Lipitor dose to see if the side effect lessens.

If you have severe muscle pain, contact your doctor as soon as possible. This may be a sign of a more serious condition. Your doctor might recommend that you stop taking Lipitor right away. And they’ll likely check you for rhabdomyolysis or immune-mediating necrotizing myopathy.

Liver damage

It’s possible to develop liver damage from taking statin medications such as Lipitor. Although liver damage was not a common side effect, it may still occur during Lipitor treatment.

Lipitor may cause increases in liver enzymes, which may indicate liver damage. Symptoms of liver damage include:

• yellowing of the eyes or skin
• belly pain
• nausea or vomiting

What might help

If you have any symptoms of liver damage during your treatment with Lipitor, tell your doctor right away. They can order blood tests to see how well your liver is working.

Your doctor will also check your liver function by ordering blood tests before you start taking Lipitor and throughout treatment.

If you develop increased liver enzymes or liver damage during treatment with Lipitor, your doctor may recommend decreasing your dose of Lipitor. Or they may pause your treatment until your liver enzyme levels increase to the point that it’s safe to resume treatment.

In more severe cases, your doctor may recommend that you take a different medication instead of Lipitor to treat your condition.

Joint pain

Lipitor can cause joint pain. This was one of the more common side effects reported in studies of Lipitor.

What might help

If you experience joint pain during your treatment with Lipitor, tell your doctor. They may be able to recommend ways to decrease this side effect. For example, they may suggest taking an over-the-counter pain medication, such as Tylenol (acetaminophen) or Advil (ibuprofen).

Diarrhea

It’s possible that you may have diarrhea during Lipitor treatment. Diarrhea was a common side effect reported in studies of the drug.

Symptoms of diarrhea include:

• belly pain or cramping
• bloating
• watery stools
• having frequent bowel movements

What might help

If you have diarrhea while taking Lipitor, tell your doctor. They can determine whether Lipitor is causing your diarrhea and the best ways to treat it.

If you have diarrhea, it is important to stay hydrated. Your doctor or pharmacist may also be able to recommend other ways to treat your diarrhea. For example, they may recommend taking an over-the-counter medication such as Imodium (loperamide).

Allergic reaction

Like most drugs, Lipitor can cause an allergic reaction in some people. But it’s not clear whether this side effect occurred in studies.

Symptoms can be mild to serious and can include:

• skin rash
• itchiness
• flushing (temporary warmth, redness, or deepening of skin color)
• swelling under your skin, usually in your eyelids, lips, hands, or feet
• swelling of your mouth, tongue, or throat, which can make it hard to breathe

What might help

If you have mild symptoms of an allergic reaction, such as a mild rash, call your doctor right away. They may suggest a treatment to manage your symptoms. Examples include:

• an antihistamine you take by mouth, such as Benadryl (diphenhydramine)
• a product you apply to your skin, such as hydrocortisone cream

If your doctor confirms you’ve had a mild allergic reaction to Lipitor, they’ll decide if you should continue using it.

If you have symptoms of a severe allergic reaction, such as swelling or trouble breathing, call 911 or your local emergency number right away. These symptoms could be life threatening and require immediate medical care.

If your doctor confirms you’ve had a serious allergic reaction to Lipitor, they may have you switch to a different treatment.

Keeping track of side effects

During your Lipitor treatment, consider taking notes on any side effects you’re having. You can then share this information with your doctor. This is especially helpful when you start taking new drugs or using a combination of treatments.

Your side effect notes can include things such as:

• what dose of the drug you were taking when you had the side effect
• how soon you had the side effect after starting that dose
• what your symptoms were
• how it affected your daily activities
• what other medications you were taking
• any other information you feel is important

Keeping notes and sharing them with your doctor will help them learn more about how Lipitor affects you. They can then use this information to adjust your treatment plan if needed.

Lipitor may not be right for you if you have certain medical conditions. These are known as drug-condition interactions. Other factors may also affect whether Lipitor is a good treatment option for you.

Talk with your doctor about your health history before starting Lipitor. The list below includes factors to consider.

Allergic reaction. If you’ve had an allergic reaction to Lipitor or any of its ingredients, your doctor will likely not prescribe Lipitor. Ask them what other medications are better options for you.

Diabetes. It’s possible that Lipitor may worsen diabetes. If you have diabetes, tell your doctor before starting treatment with Lipitor. Your doctor can determine if it’s safe for you to take the drug. Or they may recommend a different treatment option for you.

Thyroid problems. People with certain thyroid problems may have an increased risk of side effects, such as muscle pain, from taking Lipitor. Before you start taking Lipitor, tell your doctor about any thyroid problems that you have. Your doctor can help treat your thyroid condition before Lipitor treatment.

Kidney problems. Lipitor can cause muscle problems, which in rare cases may lead to kidney problems. If you already have kidney problems, taking this medication may worsen your condition. Your doctor can determine if it’s safe for you to take Lipitor with your kidney condition.

Stroke or mini-stroke in the last 6 months. Taking Lipitor after having a stroke or mini-stroke in the last 6 months may increase your risk of having another stroke. If you’ve had a recent stroke or mini-stroke, tell your doctor before starting treatment with Lipitor.

Liver problems. People with liver problems should not use Lipitor due to the risk of harm. Lipitor may cause liver problems to occur. If you already have a liver problem, taking this drug may worsen your condition. Due to this risk, your doctor will likely recommend a different treatment option for you.

Alcohol and Lipitor

There aren’t any known interactions between Lipitor and alcohol. But alcohol and Lipitor can both cause liver damage. So drinking alcohol while taking Lipitor may further increase the risk of liver problems.

If you drink alcohol, talk with your doctor about how much alcohol, if any, may be safe to drink during Lipitor treatment.

Pregnancy and breastfeeding while taking Lipitor

Lipitor may not be safe to take during pregnancy or while breastfeeding.

Currently, there is not enough information to determine if Lipitor affects a developing fetus, but it is possible. So, your doctor may not prescribe the drug during pregnancy.

It’s also unknown if Lipitor passes into breast milk or affects a child who is breastfed. Due to the possible risks, your doctor may advise you to avoid breastfeeding while taking Lipitor.

If you’re pregnant or breastfeeding or planning to become pregnant or breastfeed, tell your doctor before starting Lipitor treatment. They can help you understand the risks of taking Lipitor during these times. They may also recommend a different treatment option for you.

You may have side effects during your treatment with Lipitor. In most cases, its side effects are mild. But it’s possible to develop serious side effects from this medication.

Before you start treatment with Lipitor, talk with your doctor about side effects that could occur. Here are some questions to help get you started:

• Can Lipitor cause long-term side effects?
• Do I have an increased risk of Lipitor’s side effects due to my other medical conditions?
• How do the side effects of Lipitor compare with those of other drugs used to treat my condition?
• What should I do if I become pregnant during treatment with Lipitor?

To learn more about Lipitor, see these articles:

• All About Lipitor
• Dosage for Lipitor: What You Need to Know
• Lipitor Interactions: Alcohol, Medications, and Others
• Lipitor vs. Crestor: What You Should Know

To get information on different conditions and tips for improving your health, subscribe to any of Healthline’s newsletters. You may also want to check out the online communities at Bezzy. It’s a place where people with certain conditions can find support and connect with others.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

Statins and Weight Gain | Cardiology | JAMA Internal Medicine

Statins and Weight Gain | Cardiology | JAMA Internal Medicine | JAMA Network










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Editor’s Note

July 2014

Rita F.  Redberg, MD, MSc

JAMA Intern Med. 2014;174(7):1046. doi:10.1001/jamainternmed.2014.1994

There remains much controversy over the risks and benefits of statins for primary prevention. Besides the risks of muscle aches, diabetes, and cognitive dysfunction, I have observed over the years that for many patients, statins provide a false reassurance, as people seem to believe that statins can compensate for poor dietary choices and a sedentary life. In an elegantly performed analysis of NHANES data from 1999 to 2010, Sugiyama and colleagues¹ have documented exactly such behavior. They found that compared with statin nonusers, statin users significantly increased their fat intake and calorie consumption, along with their BMI, in the last decade. This article raises concerns of a potential moral hazard of statin use, in addition to the already known adverse effects. Focusing on cholesterol levels can be distracting from the more beneficial focus on healthy lifestyle to reduce heart disease risk.

References

1.

Sugiyama
 T, Tsugawa
 Y, Tseng
 C-H, Kobayashi
 Y, Shapiro
 MF.  Different time trends of caloric and fat intake between statin users and nonusers among US adults: gluttony in the time of statins? [published online April 24, 2014].  JAMA Intern Med. doi:10.1001/jamainternmed.2014.1927.Google Scholar

Lipitor tablets 20 mg, 30 pcs 10 Dosage form

Coated tablets

Indications for use

Primary hypercholesterolemia (heterozygous familial and non-familial hypercholesterolemia, Frederickson type IIa), combined (mixed) hyperlipidemia (Frederickson type IIb and III), dysbetalipoproteinemia (Frederickson type III) (as an adjunct to diet), familial endogenous hypertriglyceridemia (Frederickson type IV), resistant to dietary treatment.

Homozygous hereditary hypercholesterolemia (as an adjunct to lipid-lowering therapy, including autohemotransfusion of LDL-purified blood).

Also indications for treatment are cardiovascular diseases against the background of dyslipidemia, secondary prevention in order to reduce the overall risk of death, myocardial infarction and re-hospitalization for angina pectoris.

Contraindications

Hypersensitivity to the components of the drug, active liver diseases (including active chronic hepatitis, chronic alcoholic hepatitis), increased activity of “liver” transaminases (more than 3 times) of unknown origin, liver failure (severity A and B on the Child-Pugh scale), pregnancy, lactation.

Caution. Severe electrolyte imbalance, endocrine and metabolic disorders, alcoholism, history of liver disease, arterial hypotension, severe acute infections, uncontrolled seizures, major surgery, trauma, childhood (efficacy and safety of use have not been established).

How to use: dosage and course of treatment

By mouth, taken at any time of the day, with or without food. The initial dose is 10 mg 1 time per day. The dose should be changed at intervals of at least 4 weeks. The maximum daily dose is 80 mg in 1 dose.

For primary hypercholesterolemia and combined (mixed) hyperlipidemia, 10 mg once a day is prescribed. The effect of treatment is manifested within 2 weeks, the maximum effect is observed within 4 weeks.

In homozygous familial hypercholesterolemia, 80 mg is prescribed once a day (lowering LDL by 18-45%).

Before starting therapy, the patient must be prescribed a standard hypocholesterolemic diet, which he must follow during treatment.

Pharmacological action

Lipid-lowering drug from the statin group. Selective competitive inhibitor of HMG-CoA reductase, an enzyme that converts 3-hydroxy-3-methylglutaryl coenzyme A to mevalonic acid, which is a precursor of sterols, including cholesterol.

TG and cholesterol in the liver are included in the composition of VLDL, enter the plasma and are transported to peripheral tissues. LDL is formed from VLDL during interaction with LDL receptors.

The drug reduces plasma cholesterol and lipoprotein levels by inhibiting HMG-CoA reductase, cholesterol synthesis in the liver and increasing the number of “liver” LDL receptors on the cell surface, which leads to increased uptake and catabolism of LDL.

Reduces the formation of LDL, causes a pronounced and persistent increase in the activity of LDL receptors. Reduces LDL levels in patients with homozygous familial hypercholesterolemia, which usually does not respond to lipid-lowering drugs.

Reduces total cholesterol by 30-46%, LDL – by 41-61%, apolipoprotein B – by 34-50% and TG – by 14-33%; causes an increase in the level of HDL-cholesterol (high density lipoprotein) and apolipoprotein A.

Taking the drug Lipitor dose-dependently reduces the level of LDL in patients with homozygous hereditary hypercholesterolemia, resistant to therapy with other lipid-lowering drugs.

Treatment with Lipitor significantly reduces the risk of ischemic complications (including the development of death from myocardial infarction) by 16%, the risk of re-hospitalization for angina pectoris accompanied by signs of myocardial ischemia – by 26%.

Atorvastatin is not carcinogenic or mutagenic.

Side effects

From the side of the nervous system: more often than 2% – insomnia, dizziness; less often 2% – headache, asthenia, malaise, drowsiness, unusual dreams, amnesia, paresthesia, peripheral neuropathy, amnesia, emotional lability, ataxia, facial paralysis, hyperkinesis, depression, hyperesthesia, loss of consciousness.

From the senses: less than 2% – amblyopia, ringing in the ears, dryness of the conjunctiva, disturbance of accommodation, hemorrhage in the eyes, deafness, glaucoma, parosmia, loss of taste, taste perversion.

From the digestive system: more often 2% – nausea; less than 2% – heartburn, constipation or diarrhea, flatulence, gastralgia, abdominal pain, anorexia, decreased or increased appetite, dry mouth, belching, dysphagia, vomiting, stomatitis, esophagitis, glossitis, erosive and ulcerative lesions of the oral mucosa, gastroenteritis, hepatitis, biliary colic, cheilitis, duodenal ulcer, pancreatitis, cholestatic jaundice, liver dysfunction, rectal bleeding, melena, bleeding gums, tenesmus.

From the respiratory system: more often than 2% – bronchitis, rhinitis; less than 2% – pneumonia, dyspnea, bronchial asthma, epistaxis.

From the CCC: more often than 2% – chest pain; less than 2% – palpitations, vasodilation, migraine, postural hypotension, increased blood pressure, phlebitis, arrhythmia, angina pectoris.

From the side of the hematopoietic system: rarely 2% – anemia, lymphadenopathy, thrombocytopenia.

From the musculoskeletal system: more often 2% – arthritis; less than 2% – leg muscle cramps, bursitis, tendosynovitis, myositis, myopathy, arthralgia, myalgia, rhabdomyolysis, torticollis, muscle hypertonicity, joint contractures.

From the genitourinary system: more often 2% – urogenital infections, peripheral edema; less often 2% – dysuria (including pollakiuria, nocturia, urinary incontinence or urinary retention, imperative urge to urinate), nephritis, hematuria, vaginal bleeding, nephrourolithiasis, metrorrhagia, epididymitis, decreased libido, impotence, impaired ejaculation.

On the part of the skin: more than 2% – alopecia, xeroderma, increased sweating, eczema, seborrhea, ecchymosis, petechiae.

Allergic reactions to the components of the drug: less than 2% – pruritus, skin rash, contact dermatitis, rarely – urticaria, angioedema, facial edema, photosensitivity, anaphylaxis, erythema multiforme exudative (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell’s syndrome).

Laboratory indicators: less than 2% – hyperglycemia, hypoglycemia, increased serum CPK, albuminuria.

Other: less than 2% – weight gain, gynecomastia, mastodynia, exacerbation of gout.

Overdose.

Treatment of overdose: there is no specific antidote, symptomatic therapy is carried out. Hemodialysis is ineffective.

Special instructions

Treatment may cause an increase in serum CPK, which should be taken into account in the differential diagnosis of retrosternal pain.

It is necessary to regularly monitor liver function indicators before starting treatment, 6 and 12 weeks after the start of the drug or after increasing the dose, and periodically during the entire period of use (until the condition of patients with transaminase levels exceeding normal is completely normalized). An increase in “liver” transaminases is observed mainly in the first 3 months of using the drug.

It is recommended to stop the drug or reduce the dose if the increase in AST and ALT values ​​is more than 3 times. The use of the drug should be temporarily discontinued with the development of clinical symptoms suggesting the presence of acute myopathy, or in the presence of factors predisposing to the development of acute renal failure against the background of rhabdomyolysis (severe infections, hypotension, traumatic surgery, trauma, metabolic, endocrine or severe electrolyte disturbances). Patients should be warned that they should immediately consult a doctor if unexplained pain or weakness in the muscles occurs, especially if they are accompanied by malaise or fever.

Women of reproductive age should use reliable methods of contraception.

Limited experience with 80 mg/day in children. Controlled studies in children have not been conducted, however, adverse reactions when using the drug in 8 children older than 9 years with familial homozygous hypercholesterolemia at a dose of up to 80 mg / day for 1 year were not detected.

Use in pregnancy and lactation

The drug is contraindicated in pregnancy and lactation.

Interactions

Co-administration of cyclosporine, fibrates, erythromycin, clarithromycin, immunosuppressive, antifungal drugs (related to azoles) and nicotinamide with atorvastatin increases plasma concentrations of atorvastatin (and the risk of myopathy).

Antacids reduce concentration by 35% (the effect on LDL cholesterol does not change).

Simultaneous use of atorvastatin with protease inhibitors, known as inhibitors of cytochrome CYP3A4, is accompanied by an increase in plasma concentrations of the drug.

When digoxin is used in combination with atorvastatin at a dose of 80 mg/day, the concentration of digoxin increases by approximately 20%.

Increases the concentration by 20% (when administered with the drug at a dose of 80 mg / day) of oral contraceptives containing norethindrone and ethinyl estradiol.

The lipid-lowering effect of the combination with colestipol is superior to that of either drug alone.

Storage conditions

Keep out of reach of children at temperatures up to 25°C.

Shelf life

2 years.

Terms of dispensing from pharmacies

By prescription.

Brand:

Phizer

Brand:

Turkey

Active ingredient ENG:

atorvastatin

Barcode:

8 699532095015

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Weight gain preparations – indications and contraindications

To improve physical indicators bodybuilders, bodybuilders and athletes buy drugs for weight gain. One of the most popular varieties of such drugs are drugs that contain peptides. The class of medical devices in most cases is effective when an athlete needs a quick and high-quality weight gain.

Weight gain preparations with peptides

Peptides in weight gain preparations consist of protein fragments. Depending on the type of peptide preparation, the protein can be of both artificial and natural origin. Amino acid residues in the composition of medical products are linked by a peptide bond, which is why they are called so. Otherwise, weight gain drugs with peptides are called “information agents.” The active substance is responsible for the transfer of data between the smallest particles of the body.

Peptide weight gainers have the following effects on the body:

• gain muscle mass;
• balance of body functioning;
• stress reduction;
• Increase endurance and strength.

The advantage of weight gain products with peptides is that they are easily absorbed, and the risk of negative effects on the body during the course is minimized.

The best weight gain drugs with peptides

In sports pharmacology, there are 10 weight gain drugs with peptides that are in consistently high demand among athletes:

• Thymosin beta-4;
• Sermorelin;
• PEG-MGF;
• Melanotan 1;
• Melanotan 2;
• Ipamorelin;
• IGF1-LR3;
• GH FRAG 176-191;
• Hexarelin;
• GHRP-6 and GHRP-2;
• CJC-1295 DAC.