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What are side effects of macrobid: Uses, Dosage, Side Effects, Interactions, Warning

Macrobid Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing


This medication is an antibiotic used to treat bladder infections (acute cystitis). It works by stopping the growth of bacteria.This antibiotic treats only bacterial infections. It will not work for viral infections (such as common cold, flu). Using any antibiotic when it is not needed can cause it to not work for future infections.This medication should not be used in infants younger than 1 month old (see also Precautions section). This drug should not be used to treat infections outside the bladder (including kidney infections such as pyelonephritis or perinephric abscesses).

How to use Macrobid

Take this medication by mouth with food as directed by your doctor, usually twice daily (every 12 hours). Swallow the medication whole for best results.

Do not use magnesium trisilicate-containing antacids while taking this medication. These antacids can bind with nitrofurantoin, preventing its full absorption into your system.

For the best effect, take this antibiotic at evenly spaced times. To help you remember, take this medication at the same time(s) every day.

Continue to take this medication until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping the medication too early may allow bacteria to continue to grow, which may result in a return of the infection.

Tell your doctor if your condition lasts or gets worse.

Side Effects

Nausea, headache may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

This medication may cause your urine to turn dark yellow or brown in color. This is usually a harmless, temporary effect and will disappear when the medication is stopped. However, dark brown urine can also be a sign of rare side effects (liver problems or anemia). Get medical help right away if you notice dark urine along with any of the following symptoms: nausea/vomiting that doesn’t stop, stomach/abdominal pain, yellowing eyes/skin, tiredness, fast/pounding heartbeat.

Tell your doctor right away if you have any serious side effects, including: headaches that are severe or don’t go away, eye pain, vision changes, mental/mood changes, new signs of infection (such as sore throat that doesn’t go away, fever), easy bruising/bleeding.

Get medical help right away if you have any very serious side effects, including: numbness/tingling of the hands/feet, unusual muscle weakness.

This medication may rarely cause very serious (possibly fatal) lung problems. Lung problems may occur within the first month of treatment or after long-term use of nitrofurantoin (generally for 6 months or longer). Get medical help right away if you develop symptoms of lung problems, including: cough that doesn’t go away, chest pain, shortness of breath/trouble breathing, joint/muscle pain, bluish/purplish skin.

This medication may rarely cause a severe intestinal condition due to a bacteria called C. difficile. This condition may occur during treatment or weeks to months after treatment has stopped. Tell your doctor right away if you develop: diarrhea that doesn’t stop, abdominal or stomach pain/cramping, blood/mucus in your stool.

If you have these symptoms, do not use anti-diarrhea or opioid products because they may make symptoms worse.

Use of nitrofurantoin for prolonged or repeated periods may result in oral thrush or a new vaginal yeast infection. Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge, or other new symptoms.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.


Before taking nitrofurantoin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease (including liver problems caused by nitrofurantoin in the past), a certain genetic condition (G-6-PD deficiency), lung disease, numbness/tingling of the arms/legs, vitamin B deficiency, mineral imbalance, blood disorders (such as anemia), diabetes, ongoing weakness due to long-term disease, certain eye disorders (such as optic neuritis).

Older adults may be at a greater risk for side effects while using this drug, especially nerve, liver or lung problems.

This medication may cause live bacterial vaccines (such as typhoid vaccine) to not work well. Tell your health care professional that you are using this medication before having any immunizations/vaccinations.

During pregnancy, this medication should be used only when clearly needed. It must not be used if you are near the end of your pregnancy (38-42 weeks), or at the time of labor and delivery. Doing so may cause a certain blood disorder (hemolytic anemia) in your baby. Discuss the risks and benefits with your doctor.

This medication passes into breast milk and may have undesirable effects on nursing infants younger than 1 month old or those with a certain genetic condition (G-6-PD deficiency). Consult your doctor before breast-feeding.


See also How to Use section.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Some products that may interact with this drug are: certain drugs to treat gout (uricosuric drugs such as sulfinpyrazone).

This medication may interfere with certain laboratory tests (certain urine glucose tests), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Does Macrobid interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker


If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Do not share this medication with others.

This medication has been prescribed for your current condition only. Do not use it later for another infection unless your doctor tells you to.

Lab and/or medical tests (such as kidney/liver function, blood counts/CBC, bacterial culture) should be done while you are taking this medication. Lung function tests should be performed if you are prescribed nitrofurantoin products for extended treatment (several months or more). Keep all medical and lab appointments. Consult your doctor for more details.

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.


Macrobid 100 mg capsule

Color: yellow,blackShape: oblongImprint: Macrobid 52427-285

This medicine is a yellow black, oblong, capsule imprinted with “Macrobid” and “52427-285”.

Macrobid 100 mg capsule

Color: yellow,blackShape: oblongImprint: Macrobid Norwich Eaton

This medicine is a yellow black, oblong, capsule imprinted with “Macrobid” and “52427-285”.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Side effects of nitrofurantoin – NHS

Like all medicines, nitrofurantoin can cause side effects, although not everyone gets them.

Common side effects

There are things you can do to help cope with these common side effects of nitrofurantoin.

Feeling sick (nausea)

Taking nitrofurantoin with or after a meal or snack should help prevent this. It may also help if you avoid rich or spicy food.

Being sick (vomiting)

Have frequent sips of fluids, such as water or squash, to avoid dehydration. Signs of dehydration include peeing less than usual or having strong-smelling pee. Do not take any other medicines to treat vomiting without speaking to a pharmacist or doctor.

If you take contraceptive pills and you’re being sick, your contraception may not protect you from pregnancy. Check the pill packet for advice.


Drink lots of fluids, such as water or squash, to avoid dehydration. Signs of dehydration include peeing less than usual or having strong-smelling pee. Do not take any other medicines to treat diarrhoea without speaking to a pharmacist or doctor.

If you take contraceptive pills and you have severe diarrhoea for more than 24 hours, your contraception may not protect you from pregnancy. Check the pill packet for advice.

Loss of appetite

Eat when you would usually expect to be hungry. If it helps, eat smaller meals more often than usual. Snack when you’re hungry. Have nutritious snacks that are high in calories and protein, such as dried fruit and nuts.


Make sure you rest and drink plenty of fluids. Do not drink too much alcohol. Painkillers you can buy without a prescription, such as paracetamol and ibuprofen, are safe to take with nitrofurantoin. Speak to your doctor if these do not help or the headaches are severe.

Dizziness or feeling sleepy

If nitrofurantoin makes you feel dizzy, stop what you’re doing and sit or lie down until you feel better. Do not drive a car or ride a bike while you’re feeling dizzy or sleepy.

Keep taking the medicine, but speak to a doctor if the advice on how to cope does not help and a side effect is still bothering you or does not go away.

Nitrofurantoin may cause your pee to turn dark yellow or a brownish colour. This is normal and is not a reason to stop taking the medicine. Your pee will return to its usual colour once you stop taking nitrofurantoin.

Serious side effects

Serious side effects are rare and happen in less than 1 in 1,000 people.

Call a doctor or call 111 straight away if you have:

  • a cough, coughing up blood or mucus, shortness of breath, pain when you breathe or a high temperature – these can be signs of lung problems
  • pale poo and dark pee together, or the whites of your eyes turn yellow or your skin turns yellow (this may be less obvious on brown or black skin) – this can be a sign of liver or gallbladder problems
  • bruising or bleeding you cannot explain (including nosebleeds), sore throat, a high temperature and feeling tired or generally unwell – these can be signs of blood problems
  • severe headaches

Immediate action required: Call 999 or go to A&E if:

  • you get chest pain or difficulty breathing – these can be signs of lung problems
  • you get pins and needles, tingling sensations, numbness or weakness – these can be signs of nerve problems

Serious allergic reaction

In rare cases, it’s possible to have a serious allergic reaction to nitrofurantoin (anaphylaxis).

Immediate action required: Call 999 or go to A&E now if:

  • you get a skin rash that may include itchy, red, swollen, blistered or peeling skin
  • you’re wheezing
  • you get tightness in the chest or throat
  • you have trouble breathing or talking
  • your mouth, face, lips, tongue or throat start swelling

You could be having a serious allergic reaction and may need immediate treatment in hospital.

Other side effects

These are not all the side effects of nitrofurantoin. For a full list see the leaflet inside your medicines packet.


You can report any suspected side effect using the Yellow Card safety scheme.

Visit Yellow Card for further information.

Page last reviewed: 7 January 2022

Next review due: 7 January 2025

Macrobid Capsule in English – Product

Macrobid Capsule / Macrobid Capsule in English – Product – Medicine.net

About Us

  • About Us
  • 9000 Privacy Policy 8
  • Terms of use


  • Overview
  • Benefits
  • Side effects
  • Precautions
  • Interactions
  • Contraindications


Macrobid Capsule is used for Bacterial bladder infections, Urinary tract infection, Urinary tract infections and other conditions.

Macrobid Capsule contains the following active ingredients: Macrocrystalline, Nitrofurantoin and Nitrofurantoin. Available in capsule form.

Detailed information regarding the use, composition, dosage, side effects of Macrobid Capsule / Macrobid Capsule, as well as user reviews are provided below:


Macrobid Capsule is used for the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms:

Learn more: Benefits

Side Effects

The following is a list of possible side effects that may be caused by the constituents of Macrobid Capsule. This list is not final. These side effects have been recorded previously, but are not always recorded when using the drug. Some of these side effects may be extremely rare, but have incredibly severe consequences. If you notice any side effects, contact your doctor immediately. Especially in the case of observing side effects for a long time.

  • Cramping abdominal pain
  • Bone pain or stiffness
  • Severe pulmonary reactions
  • Inflammation of the salivary gland or pancreas
  • Serious allergic reactions
  • Vertigo
  • Rash
  • Nausea
  • Butterfly-shaped skin rash on nose
  • Random eye movement
  • Feelings of excitement and happiness
  • Abdominal pain
  • Abnormal blood tests
  • Vomiting
  • Drowsiness
  • Psychotic reactions
  • Confusion
  • Depression
  • Drug-associated fever
  • Numbness over arms
  • 900 06 Loss of appetite

  • Diarrhea
  • Tingling
  • Rapid swelling of face or lips
  • Headache
  • Itching skin rash
  • Nerve injury causing pain
  • Weak spot
  • Anorexia
  • Urticaria
  • Lupus syndrome
  • Hemolytic anemia
  • Peripheral polyneuropathy
  • Hepatotoxicity
  • Allergic reaction
  • Intersty social pneumonitis

If you experience side effects not listed above, contact your healthcare provider for advice. In addition, you can report side effects to your local Food and Drug Administration.


Before starting this drug, tell your doctor about any medications you are taking, dietary supplements (such as vitamins, natural supplements, etc.), allergies, existing medical conditions, and current health conditions (such as pregnancy, upcoming surgery, and etc.). The side effects of the drug may be more pronounced depending on the state of your body. Take this medicine as directed by your doctor, or follow the directions for use that come with your medicine. The dosage of the drug depends on your condition. Tell your doctor if there is no change or if your condition worsens. Important points to discuss with your healthcare provider are listed below.

  • Take tablets after meals or milk for easy absorption
  • Do not drive or operate heavy machinery
  • Do not use this drug during pregnancy and lactation
  • Do not use this drug with antacids containing magnesium

9003 7

If you if you are taking other drugs or over the counter products at the same time, the effects of Macrobid Capsule may change. Tell your healthcare provider about all medications, vitamins, and supplements you use. Your doctor will be able to make the right plan for taking the drug, which will avoid negative interactions. Macrobid Capsule may interact with the following drugs and products:

  • Amphotericin B
  • Ascorbic acid
  • Fosphenytoin
  • Gestodene
  • Magnesium oxides and hydroxides
  • Nalidixic acid
  • 9000 6 Probenecid

  • Propantheline
  • Pyridoxine
  • Sulphinpyrazone

Hypersensitivity to Macrobid Capsule is a contraindication. In addition, Macrobid Capsule should not be used if you have the following conditions:

  • Pregnancy and newborns
  • Oliguria or anuria
  • impaired renal function
  • hypersensitivity

Composition and active ingredients

Packing options and strength of the drug

Macrobid Capsule is available in the following packages and strengths

Available Packaging Macrobid Capsule: 75MG, 25MG


  • Can Macrobid Capsule be used for bacterial bladder and urinary tract infections?

    Yes, bacterial bladder infections and urinary tract infection are among the most common reported uses for Macrobid Capsule. Please do not use Macrobid Capsule for bacterial bladder infections and urinary tract infections without consulting first with your doctor. Click here and view survey results to find out what other patients report as using Macrobid Capsule.

  • Should I use this product on an empty stomach, before or after meals?

    TabletWise.com users have reported taking Macrobid Capsule after meals. However, this information may not apply to your specific situation. Please check with your healthcare provider for a schedule. Click here and view survey results to find out what other patients report as timings of using Macrobid Capsule.

  • Is it safe to drive or operate heavy machinery while using this product?

    If you experience drowsiness, dizziness, hypotension or a headache as side-effects when using Macrobid Capsule medicine then it may not be safe to drive a vehicle or operate heavy machinery. You should stop driving if taking this medicine makes you drowsy, dizzy, or hypotensive. Doctors recommend that you stop drinking alcohol with such drugs, because. alcohol greatly increases the side effects and drowsiness. Please check for these effects on your body when using Macrobid Capsule. Be sure to consult your doctor for advice based on the characteristics of your body and general health.

  • Is this drug (product) addictive or addictive?

    Most drugs are not habit-forming or addictive. In most cases, the state classifies drugs that can be addictive as controlled dispensing drugs. For example, schedule H or X in India and schedule II-V in the USA. Please check the information on the drug packaging to make sure that this drug is not in the controlled category. Also, do not self-medicate or accustom your body to medications without consulting your doctor.

  • Can I stop using this product immediately or do I need to slowly stop using it?

    Some medications need to be stopped gradually due to a rebound effect. Be sure to consult your healthcare provider for advice based on your body, general health, and other medications you may be taking.

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Macrobid Capsule

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More information about Macrobid Capsule

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Last updated date

This page was updated on 9/28/2020.