How does metaxalone work as a muscle relaxant. What are the common side effects of metaxalone. When should you not take metaxalone. How is metaxalone properly stored and disposed of. What precautions should be taken when using metaxalone.

Understanding Metaxalone: A Comprehensive Guide to This Muscle Relaxant

Metaxalone is a prescription medication used primarily as a muscle relaxant. It belongs to a class of drugs known as skeletal muscle relaxants and is often prescribed to alleviate pain and discomfort associated with acute musculoskeletal conditions. This article delves into the various aspects of metaxalone, including its uses, dosage, side effects, and important precautions.

The Primary Uses of Metaxalone in Medical Treatment

Metaxalone is primarily prescribed for the following purposes:

• Relieving muscle pain and discomfort caused by strains, sprains, and other muscle injuries
• Complementing rest and physical therapy in the treatment of musculoskeletal conditions
• Providing short-term relief for acute skeletal muscle spasms

It’s important to note that metaxalone is typically used as part of a comprehensive treatment plan that may include rest, physical therapy, and other measures to promote muscle relaxation and pain relief.

How does metaxalone work in the body?

Metaxalone works by affecting the central nervous system to induce muscle relaxation. While its exact mechanism of action is not fully understood, it is believed to depress the central nervous system, particularly at the level of the spinal cord and subcortical areas of the brain. This depression leads to a reduction in muscle tone and tension, ultimately providing relief from muscle spasms and associated pain.

Proper Dosage and Administration of Metaxalone

The correct dosage of metaxalone can vary depending on the individual patient and their specific condition. However, some general guidelines include:

• Typical dosage: 800 mg taken three to four times daily
• Maximum daily dose: 3200 mg
• Administration: Take by mouth with or without food

It’s crucial to follow the prescribing physician’s instructions carefully and not exceed the recommended dose. Patients should also be aware that the effects of metaxalone may be enhanced when taken with food.

Can the dosage of metaxalone be adjusted?

Yes, the dosage of metaxalone can be adjusted by a healthcare provider based on the patient’s response to treatment and any side effects experienced. It’s important never to adjust the dosage without consulting a doctor first. Some patients may require lower doses, particularly if they are elderly or have liver or kidney impairment.

Potential Side Effects and Adverse Reactions to Metaxalone

Like all medications, metaxalone can cause side effects. While not everyone experiences these, it’s important to be aware of potential adverse reactions:

Common side effects:

• Drowsiness
• Dizziness
• Headache
• Nervousness
• Nausea
• Irritability

Serious side effects (rare but require immediate medical attention):

• Severe skin rash
• Difficulty breathing
• Yellowing of the skin or eyes (jaundice)
• Unusual bruising or bleeding
• Severe fatigue or weakness
• Seizures

If any severe side effects occur, it’s crucial to seek medical help immediately. Additionally, patients should report any persistent or bothersome side effects to their healthcare provider.

Are there any long-term effects of using metaxalone?

While metaxalone is generally prescribed for short-term use, long-term effects are not well-documented. Prolonged use of muscle relaxants like metaxalone may lead to dependence or tolerance. Therefore, it’s essential to use this medication only as directed by a healthcare provider and for the shortest duration necessary to achieve the desired therapeutic effect.

Important Precautions and Contraindications for Metaxalone Use

Before taking metaxalone, patients should be aware of several important precautions:

• Allergies: Inform your doctor of any allergies to metaxalone or its ingredients
• Medical history: Disclose any history of kidney disease, liver disease, seizures, or blood disorders
• Pregnancy and breastfeeding: Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding
• Age considerations: Older adults (65 years or older) should use caution as they may be more sensitive to side effects
• Alcohol interaction: Avoid alcohol consumption as it can enhance the drowsiness caused by metaxalone
• Driving and operating machinery: Exercise caution until you know how metaxalone affects you

Who should not take metaxalone?

Metaxalone may not be suitable for everyone. It should be avoided or used with caution in the following situations:

• Individuals with known hypersensitivity to metaxalone or any of its components
• Patients with severe liver disease
• Those with a history of drug abuse or addiction
• Individuals taking certain medications that may interact with metaxalone

Always consult with a healthcare provider to determine if metaxalone is appropriate for your specific situation.

Drug Interactions and Compatibility with Other Medications

Metaxalone can interact with various medications, potentially altering their effectiveness or increasing the risk of side effects. Some notable interactions include:

• Central nervous system depressants (e.g., benzodiazepines, opioids)
• Certain antidepressants
• Antihistamines
• Alcohol

It’s crucial to inform your healthcare provider about all medications, supplements, and herbal products you are taking before starting metaxalone. This includes both prescription and over-the-counter products.

How can potential drug interactions be managed?

To manage potential drug interactions with metaxalone:

1. Provide a complete list of all medications and supplements to your healthcare provider
2. Follow dosage instructions carefully
3. Avoid alcohol consumption while taking metaxalone
4. Do not start or stop any medications without consulting your doctor
5. Be vigilant for any unusual side effects or changes in how you feel

Your healthcare provider may need to adjust dosages or monitor you more closely if you are taking medications that interact with metaxalone.

Proper Storage and Disposal of Metaxalone

Correct storage and disposal of metaxalone are essential for maintaining its effectiveness and ensuring safety:

Storage guidelines:

• Keep in the original container, tightly closed
• Store at room temperature, away from excess heat and moisture
• Keep out of reach of children and pets
• Do not store in the bathroom

Disposal methods:

• Do not flush down the toilet
• Utilize medicine take-back programs when available
• If take-back programs are not accessible, mix with an undesirable substance (e.g., used coffee grounds), seal in a plastic bag, and dispose of in household trash

Proper disposal helps prevent accidental ingestion by children or pets and reduces environmental contamination.

What should you do with expired metaxalone?

Expired metaxalone should not be used and should be disposed of properly. Check the expiration date on the medication container and follow these steps:

1. Do not flush expired metaxalone down the toilet or sink
2. Remove the medication from its original container
3. Mix with an undesirable substance like used coffee grounds or kitty litter
4. Place the mixture in a sealed plastic bag or container
5. Dispose of in your household trash
6. Remove or scratch out all personal information on the empty medication container before disposing of it

If possible, utilize a medicine take-back program for the safest disposal of expired medications.

Monitoring and Follow-up Care When Taking Metaxalone

Regular monitoring and follow-up care are essential when taking metaxalone to ensure its effectiveness and minimize potential risks:

• Schedule regular check-ups with your healthcare provider
• Report any new or worsening symptoms promptly
• Discuss the need for continued treatment, especially if using metaxalone for an extended period
• Be prepared to undergo liver function tests if prescribed for long-term use
• Keep a record of your symptoms and any side effects experienced

How often should you have follow-up appointments when taking metaxalone?

The frequency of follow-up appointments may vary depending on individual circumstances, but generally:

1. Initial follow-up: Usually within 2-4 weeks of starting treatment
2. Subsequent appointments: Every 1-3 months, or as recommended by your healthcare provider
3. Immediate consultation: If experiencing severe side effects or lack of improvement

Your healthcare provider will determine the appropriate follow-up schedule based on your response to treatment and overall health status.

Alternative Treatments and Complementary Therapies to Metaxalone

While metaxalone can be effective for muscle pain and spasms, there are alternative treatments and complementary therapies that may be considered:

• Physical therapy and exercise programs
• Massage therapy
• Acupuncture
• Heat or cold therapy
• Other muscle relaxants or pain medications
• Cognitive-behavioral therapy for chronic pain management

It’s important to discuss these options with your healthcare provider to determine the most appropriate treatment plan for your specific condition.

Can lifestyle changes help reduce the need for metaxalone?

Yes, certain lifestyle changes can potentially reduce the need for metaxalone or complement its effects:

1. Regular exercise and stretching to improve muscle strength and flexibility
2. Proper posture and ergonomics to reduce muscle strain
3. Stress reduction techniques such as meditation or yoga
4. Adequate sleep and rest to promote muscle recovery
5. Maintaining a healthy weight to reduce strain on muscles and joints
6. Proper nutrition, including adequate hydration and balanced diet

Implementing these lifestyle changes in conjunction with medical treatment can lead to better overall outcomes and potentially reduce reliance on medication.

Metaxalone: MedlinePlus Drug Information

pronounced as (me tax’ a lone)

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Metaxalone, a muscle relaxant, is used with rest, physical therapy, and other measures to relax muscles and relieve pain and discomfort caused by strains, sprains, and other muscle injuries.

Metaxalone comes as a tablet to take by mouth. It usually is taken three or four times a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take metaxalone exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking metaxalone,

• tell your doctor and pharmacist if you are allergic to metaxalone, any other medications, or any of the ingredients in metaxalone tablets. Ask your pharmacist for a list of the ingredients.
• tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take while taking metaxolone. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
• tell your doctor if you have or have ever had kidney disease, liver disease, seizures, or a blood disorder.
• tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking metaxalone, call your doctor immediately.
• talk to your doctor about the risks and benefits of taking metaxalone if you are 65 years of age or older. Older adults should not usually take metaxalone because it is not as safe or effective as other medications that can be used to treat the same condition.
• you should know that this drug may make you drowsy. Do not drive a car or operate machinery until you know how metaxalone affects you.
• remember that alcohol can add to the drowsiness caused by this drug.

Take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Metaxalone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• drowsiness
• dizziness
• headache
• nervousness

If you experience any of the following symptoms, call your doctor immediately:

• agitation, hallucinations, coma
• fast heart rate, high body temperature
• muscle twitching, loss of muscle control
• nausea, vomiting, diarrhea
• severe skin rash
• difficulty breathing
• yellowing of the skin or eyes
• unusual bruising or bleeding
• unusual tiredness or weakness
• seizures

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online (http://www. fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature, away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA’s Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can’t be awakened, immediately call emergency services at 911.

• Skelaxin^®

Last Revised – 07/15/2022

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Metaxalone Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

See also How to Use section.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Some products that may interact with this drug include: diet pills/appetite suppressants (such as diethylpropion), drugs for attention deficit disorder (such as atomoxetine, methylphenidate), apraclonidine, bupropion, buspirone, carbamazepine, cyclobenzaprine, deutetrabenazine, a certain combination product (dextromethorphan/quinidine), levodopa, maprotiline, methyldopa, metoclopramide, certain opioid pain relievers (such as fentanyl, meperidine, methadone, tapentadol), certain drugs for Parkinson’s disease (such as entacapone, tolcapone), certain supplements (such as tryptophan, tyramine), tetrabenazine, tricyclic antidepressants (such as amitriptyline, doxepin), valbenazine.

The risk of serotonin syndrome/toxicity increases if you are also taking other drugs that increase serotonin. Examples include street drugs such as MDMA/”ecstasy,” St. John’s wort, certain antidepressants (including mirtazapine, SSRIs such as fluoxetine/paroxetine, SNRIs such as duloxetine/venlafaxine), tramadol, certain “triptans” used to treat migraine headaches (such as rizatriptan, sumatriptan, zolmitriptan), among others. The risk of serotonin syndrome/toxicity may be more likely when you start or increase the dose of these drugs.

Some products can interact with metaxalone if you take them together, or even if you take them weeks before or after taking metaxalone. Tell your doctor or pharmacist if you take anything in the list of products that may interact with this drug, or any of the products that increase serotonin, within 2 weeks before or after taking metaxalone. Also tell them if you have taken fluoxetine within 5 weeks before starting metaxalone. Ask your doctor how much time to wait between starting or stopping any of these drugs and starting metaxalone.

Taking other MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Do not take any other MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before and after treatment with this medication. Ask your doctor when to start or stop taking this medication.

Before using metaxalone, report the use of drugs that may increase the risk of extremely high blood pressure (hypertensive crisis) when combined with metaxalone, including herbal products (such as ephedra/ma huang), nasal decongestants (such as phenylephrine, pseudoephedrine), and stimulants (such as amphetamines, ephedrine, epinephrine, phenylalanine). Metaxalone should not be used with any of these medications. Talk to your doctor or pharmacist for more details.

Tell your doctor or pharmacist if you are taking other products that cause drowsiness such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), other muscle relaxants (such as carisoprodol, cyclobenzaprine), or antihistamines (such as cetirizine, diphenhydramine).

Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.

This medication may interfere with certain lab tests (such as certain urine glucose tests), possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug.

Does Metaxalone interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Antibiotics for sinusitis

Sinusitis is a serious disease, the development of which is based on inflammation of the paranasal (maxillary) sinuses. In most cases, the cause of the development of pathology are pathogenic microorganisms. Predisposing factors include low immunity protection, anatomical features of the nasal passages, paranasal cavities, as well as post-traumatic changes in this area that disrupt ventilation in the sinuses and narrow the nasal passages.

Untimely initiation of therapy can lead to the development of severe complications, namely, infection of the ear cavity, meninges of the brain. You can suspect sinusitis based on the following symptoms:

• nasal discharge that gradually becomes purulent and bothers for more than a week;
• nasal congestion due to swelling of the tissues, hypersecretion, which forces the person to breathe through the mouth;
• lack of smell;
• change in taste;
• fever above 39 degrees;
• pain in the paranasal region, which extends to the forehead, eye sockets, teeth, and is aggravated by tilting, turning the head;
• malaise;
• drowsiness;
• decreased motor activity.

In order to diagnose the disease in time, it is necessary to undergo an examination by a doctor at the stage of the appearance of the first clinical signs of pathology. You can consult with a qualified otolaryngologist at the Health of the capital medical center. Experienced specialists of various profiles work here, which allows us to provide medical care to adults and children.

Treatment of sinusitis is based on taking antibacterial agents. They can be used topically or systemically. Depending on the severity of the disease, the patient’s state of health, drugs can be administered orally or by injection (intramuscularly, intravenously).

Note that the dose of drugs, the type of antibiotic and the duration of therapy are set exclusively by the doctor based on the results of instrumental, laboratory examinations. Self-administration of medications can not only not bring relief to the general condition, but also worsen the course of the disease, provoke the appearance of adverse reactions.

Next, consider the groups of antibacterial agents that are most often used in the treatment of sinusitis.

• Penicillin series. The drugs are available in combination with clavulanic acid. Representatives of this group of antibiotics include Flemoxin, Amoxiclav, Augmentin, Flemoxin. Medicines are widely used in the treatment of sinusitis in children. For them, preparations are sold in the form of a suspension with the addition of fruit fillers to give a pleasant taste.
• Cephalosporins such as Ceftriaxone, Cefuroxime, Zefthera. Preparations are divided into generations, depending on the spectrum of action against pathogenic microorganisms. The choice of medicine is carried out on the basis of the results of bakposev biological material.
• Macrolides (Clarithromycin, Sumamed, Fromilid, Macropen) – act on intracellular bacteria (chlamydia, mycoplasmas). They are prescribed when the above antibiotics cannot be used due to allergic reactions or their ineffectiveness.

Antibiotics from the aminoglycoside group are prescribed for topical therapy. They have a greater number of side effects compared to other drugs, so they are rarely prescribed for systemic administration.

Polydex drops are used for intranasal administration. In their composition, they have not only an antibiotic, but also a vasoconstrictor, hormonal component. Spray Isofra is also prescribed for local use. In addition to antibacterial drugs, saline solutions are prescribed for washing the nasal passages.

An integrated approach to therapy allows you to overcome infection, reduce inflammation, eliminate nasal congestion, restore nasal breathing, alleviate the general condition of a person, and also prevent the development of complications.

Tercef instruction – Medical portal imedica.by

Name: Tercef

Pharmacological action:
Tercef is a broad-spectrum antimicrobial agent for parenteral use. Tercef contains ceftriaxone, an antibiotic of the cephalosporin group, which has a pronounced bactericidal effect. Ceftriaxone is resistant to most beta-lactamases, making it effective in infections caused by microorganisms that produce penicillinase and other beta-lactamases. Ceftriaxone leads to the death of microorganisms due to the inhibition of protein synthesis inside the bacterial cell.

Strains of gram-positive and gram-negative microorganisms are sensitive to the action of ceftriaxone, including Streptococcus pneumoniae, Streptococcus gr. A and B, Streptococcus viridans, Streptococcus bovis gr. D, Staphylococcus aureus, Staphylococcus epidermidis, Clostridium spp., Peptococcus spp., Peptostreptococcus spp., Enterobacter spp., Escherichia coli, Haemophilus influenzae, Haemophilus ducreyi, Haemophilus parainfluenzae, Morganella morganii, Klebsiella spp., Neisseria meningitides, Neisseria gonorrhoeae, Moraxella catharrhalis, Proteus spp., Salmonella spp. Serratia marcescens, Shigella spp., Pseudomonas spp., Acinetobacter calcoaceticus. Tercef is also effective against the causative agent of Lyme disease (Borrelia burgdorferi).

It should be borne in mind that strains resistant to penicillins and cephalosporins, as well as methicillin-resistant strains, are insensitive to the action of ceftriaxone.
With intramuscular administration of the drug Tercef, the peak plasma concentration of ceftriaxone is reached within 2 hours, therapeutic concentrations of the active substance in the tissues persist for 24 hours after a single injection. Ceftriaxone crosses the blood-placental and blood-brain barriers, with higher concentrations of ceftriaxone in the synovial fluid observed in patients with inflammation of the meninges. A small part of ceftriaxone is metabolized. The active component of the drug Tercef is excreted mainly by the kidneys, some part is excreted in the bile. The half-life of ceftriaxone reaches 6-9hours. In patients with impaired renal and hepatic function, as well as in newborns, the half-life of ceftriaxone may increase.

Indications for use:
Tercef is intended for the treatment of patients suffering from infectious diseases of various localization, which are caused by strains sensitive to ceftriaxone.
In particular, Tercef can be prescribed for infectious diseases of the urinary and respiratory system, musculoskeletal system (including bone and soft tissue infections), ENT organs, as well as intra-abdominal infections, meningitis, septicemia, disseminated Lyme borreliosis, infected wounds and sexually transmitted infections (including gonorrhea).
Tercef can also be used as a prophylactic during surgical interventions.

How to use:
Tercef is intended for preparation of a solution for intramuscular or intravenous administration.
To prepare a solution for intramuscular injection, the contents of the vial should be dissolved in 3.6 ml or 7.2 ml (depending on the dose of ceftriaxone at the rate of 3.6 ml of solvent per 1 g of powder) 1% lidocaine solution. Before the introduction of the drug should be tested for sensitivity to lidocaine and ceftriaxone. The finished solution should be injected immediately after preparation deep into the gluteal muscle. It should be borne in mind that the maximum recommended single dose administered per muscle is 1 g of ceftriaxone.
To prepare a solution for intravenous bolus administration, the contents of the vial should be dissolved in 9.6 ml or 19.2 ml (depending on the dose of ceftriaxone at the rate of 9.6 ml of solvent per 1 g of powder) of water for injection. Intravenous bolus injection should be administered slowly over 2-5 minutes.

To prepare a solution for intravenous administration, prepare a solution as for intravenous jet administration, after which the resulting solution is dissolved in 50 or 100 ml of water for injection or 0.9% sodium chloride solution or 5% (10%) glucose solution or 5% levulose solution. The duration of intravenous drip is usually 15-30 minutes. The duration of use and dose of ceftriaxone is determined by the doctor.
The average recommended dose for adults and adolescents is 1-2 g of ceftriaxone every 24 hours. In severe infections, the dose may be increased to 1-2 g of ceftriaxone every 12 hours. The maximum recommended daily dose of ceftriaxone for this age group is 4 g.

Patients with uncomplicated gonorrhea are usually given a single intramuscular injection of 250 mg ceftriaxone.
As a prophylactic, Tercef is prescribed at a dose of 1 g intravenously 30-120 minutes before surgery.
For children under 12 years of age, Tercef is recommended at a dose of 50-75 mg/kg body weight every 24 hours. The maximum recommended dose of ceftriaxone for this age group is 2 g.
Neonates and premature infants are advised to prescribe Tercef at a dose of 20-50 mg/kg of body weight every 24 hours.
In meningitis, an increase in the dose of Tercef to 100 mg/kg of body weight every 24 hours is allowed. The maximum recommended daily dose of ceftriaxone in this case is 4 g.

The duration of therapy with Tercef is usually from 4 to 10-14 days, depending on the nature of the disease and the type of pathogen (it is recommended to continue therapy until negative results of microbiological tests are obtained or within 2-3 days after the symptoms disappear).
Patients with impaired renal function do not require dose adjustment. With simultaneous impairment of kidney and liver function, plasma levels of ceftriaxone should be monitored.
Patients on dialysis do not require an additional dose of Tercef. The maximum recommended daily dose of ceftriaxone for this category of patients is 2 g.

Side effects:
Tercef is generally well tolerated by patients. In some cases, the development of such undesirable effects caused by ceftriaxone was noted:
From the hepatobiliary system and gastrointestinal tract: diarrhea, stomatitis, glossitis, changes in taste sensations, nausea, vomiting, dyspeptic symptoms, intestinal microflora disturbance, anorexia, pain in the abdominal and epigastric region, increased activity of liver enzymes, liver dysfunction, jaundice. In isolated cases, the development of pancreatitis and pseudomembranous colitis was noted, which requires the abolition of ceftriaxone and specific therapy. In addition, the formation of precipitates of ceftriaxone in the gallbladder is possible.

From the side of blood vessels, heart and blood system: arrhythmia, palpitations, hot flashes, epistaxis, leukopenia, thrombocytopenia, neutropenia, eosinophilia, anemia, increased prothrombin time, agranulocytosis.
From the nervous system: vertigo, headache, convulsions.
From the urinary system: hematuria, increased creatinine, glucosuria, oliguria, formation of stones in the kidneys, renal failure, anuria.
Allergic reactions: urticaria, exanthema, angioedema, Stevens-Johnson syndrome, Lyell’s syndrome, anaphylactic shock, bronchospasm.

Others: chills, hyperthermia, increased sweating, decreased visual acuity, hyperazotemia, development of superinfection. It is also possible the development of phlebitis with intravenous administration.
When Tercef is used, false-positive Coombs test results and determination of glucose in urine by non-enzymatic methods are possible.

Contraindications:
Tercef is not indicated for patients with known hypersensitivity to penicillin and cephalosporin antibiotics. Intramuscular administration is not recommended for patients with hypersensitivity to lidocaine and other local anesthetics.
It is forbidden to administer the drug Tercef simultaneously with calcium-containing solutions, as well as the appointment of ceftriaxone to patients receiving drugs containing calcium (including parenteral nutrition).
Tercef is not recommended for use as a prophylactic in neurosurgery.
Intramuscular administration of Tercef to children under 2 years of age is not recommended.

Caution should be exercised when prescribing Tercef to premature and newborn infants, especially if the child has jaundice with hypoalbuminemia or acidosis.
With caution, Tercef is prescribed to patients with impaired coagulation, colitis (including history), impaired renal and hepatic functions, as well as patients who have been receiving verapamil for a long time.
It is recommended to avoid operating potentially unsafe machinery and driving a car during treatment with Tercef.

Pregnancy:
Tercef during pregnancy can be prescribed only for health reasons.
During lactation, it is recommended to interrupt breastfeeding for the period of therapy with Tercef. Restoring breastfeeding is possible no earlier than 2-3 days after the last dose of Tercef.

Interaction with other drugs:
Simultaneous administration of a solution of ceftriaxone with calcium-containing solutions is prohibited due to the possibility of the formation of precipitates (the interval between administrations of these drugs should be at least 48 hours).
The combined use of ceftriaxone and aminoglycosides may increase the severity of ototoxic and nephrotoxic effects. If it is necessary to use these drugs simultaneously, it is recommended to observe an interval between their use of at least 2 hours.
There is an increased risk of bleeding with the combined use of Tercef with vitamin K antagonists, non-narcotic analgesics and antiplatelet agents.

Bacteriostatic drugs reduce the effectiveness of ceftriaxone.
The risk of developing nephrotoxic effects of ceftriaxone increases when used in combination with loop diuretics, as well as potentially nephrotoxic drugs.
Tercef may reduce the effectiveness of oral contraceptives.
Tercef should not be mixed with other parenteral preparations (with the exception of solutions recommended for the preparation of Tercef solution for intravenous/intramuscular administration).

Overdose:
When using high doses of Tercef, there is an increased risk of development and an increase in the severity of undesirable effects. In particular, when using high doses of ceftriaxone, leukopenia, hyperthermia, acute hemolytic anemia, undesirable effects from the digestive tract, renal failure, shortness of breath, loss of appetite, temporary hearing loss and spatial orientation disorders may develop.

No specific antidote. When an overdose of ceftriaxone is administered, the patient’s condition should be monitored and, if necessary, supportive and symptomatic therapy should be carried out.
Carrying out hemodialysis and peritoneal dialysis with an overdose of Tercef is ineffective.

Release form:
Powder for solution for parenteral administration Tercef 1 or 2 g in vials, 5 vials are enclosed in a cardboard box.

Storage conditions:
Tercef should be stored in rooms with a temperature regime of 15 to 25 degrees Celsius. The shelf life of Tercef is 3 years.
Ready solution is stable for 24 hours at temperatures from 2 to 8 degrees Celsius.

Synonyms:
Ceftriaxone, Cefaxone, Emsef, Rotacef, Medakson, Loraxon.

Composition:
1 bottle of Tercef 1 g contains:
Ceftriaxone sodium salt (equivalent to ceftriaxone) – 1000 mg.

1 bottle of Tercef 2 g contains:
Ceftriaxone sodium salt (equivalent to ceftriaxone) – 2000 mg.

Attention!
The description of the drug “ Tercef ” on this page is a simplified and supplemented version of the official instructions for use. Before purchasing or using the drug, you should consult your doctor and read the annotation approved by the manufacturer.
Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide on the appointment of the drug, as well as determine the dose and methods of its use.

Medicines have firmly entered our lives, and we cannot imagine ourselves without them. All modern methods of treatment and their effectiveness are associated with the use of drugs. Especially for you, we have created a complete table of instructions for the use of CIS medicines. This means that on the pages of the site imedica.by you will find Tercef medicine, as well as more than five thousand units of pharmacological units such as: tablets, powders, suppositories, suppositories, injections, capsules, ointments and combined pharmacological drugs.

But you wanted to find Tercef. On this page you will find instructions for using Tercef, as well as additional elements that are beyond the scope of the usual instructions. This is an almost complete description of all concomitant reactions, properties, combinations and contraindications, as well as a complete list of incompatibilities with other drugs.

The standard annotation for the Tercef preparation includes: data on pharmacological action, indications for use, method of administration, side effects, contraindications, use during pregnancy, overdose, interaction with other drugs, form of release, storage conditions, composition (active substance). And you can also look at the nosological classification according to ICD-10 and find which pharmacological group the drug belongs to, and you can easily find an analogue.