What is the dangerous interaction between oxycontin and carisoprodol? How can this combination lead to adverse effects? What should healthcare providers be aware of when prescribing these two drugs together?

Oxycontin and Carisoprodol: A Concerning Combination

Oxycontin, a time-release formulation of the opioid oxycodone, is widely used to treat chronic pain caused by conditions like cancer. However, Oxycontin is also commonly abused, making it a controlled substance. Carisoprodol (Soma), a skeletal muscle relaxant, has also demonstrated potential for abuse.

A case report describes a concerning interaction between these two drugs. A 49-year-old woman with severe back pain was prescribed 40 mg of Oxycontin twice daily, along with 350 mg of carisoprodol four times per day. When this regimen failed to provide relief, the patient increased her carisoprodol dosage to 8-10 tablets per day, unaware of the risks.

Additive Central Nervous System Depression

The patient was later found unconscious, with low blood pressure and respiratory depression. She responded rapidly to the opioid antagonist naloxone, indicating the central nervous system (CNS) depression was likely due to the combined effects of Oxycontin and carisoprodol.

Carisoprodol is metabolized to meprobamate, a Class IV controlled substance with its own CNS-depressant properties. The combination of these two CNS-depressant drugs can have a potent and dangerous additive effect, potentially leading to respiratory depression, coma, and even death.

Abuse Potential and Controlled Substance Status

The authors note that while the risks of Oxycontin are well-known, many healthcare providers may be unaware of the abuse potential and CNS-depressant effects of carisoprodol. In fact, carisoprodol has been made a controlled substance in Alabama, and may eventually be classified as such at the federal level.

Prescribing Caution and Monitoring

The authors emphasize that Oxycontin and carisoprodol should only be prescribed concurrently with extreme caution, due to the significant abuse potential and dangerous additive CNS-depressant effects. Healthcare providers should closely monitor patients taking this combination for signs of respiratory depression or other adverse events.

Conclusion

The case report highlights the potentially life-threatening interaction between Oxycontin and carisoprodol. Healthcare providers must be aware of the abuse potential and CNS-depressant properties of both drugs, and exercise caution when prescribing them together. Careful patient monitoring is essential to prevent serious adverse outcomes.

Key Takeaways

• Oxycontin and carisoprodol can have a dangerous additive CNS-depressant effect when taken together.
• Carisoprodol is metabolized to meprobamate, a controlled substance with its own CNS-depressant properties.
• Both Oxycontin and carisoprodol have significant abuse potential, making their combined use particularly risky.
• Healthcare providers must exercise extreme caution when prescribing these two drugs concurrently and closely monitor patients for adverse effects.

Preventing Dangerous Interactions

What steps can healthcare providers take to prevent dangerous interactions between Oxycontin and carisoprodol?

Healthcare providers should carefully consider the risks and benefits before prescribing Oxycontin and carisoprodol together. They should thoroughly review the patient’s medical history and medication use, and monitor the patient closely for signs of CNS depression or other adverse effects. If the two drugs must be prescribed concurrently, the lowest effective doses should be used, and the patient should be educated on the risks and warned against increasing the dosage without medical supervision.

The Importance of Awareness

Why is it important for healthcare providers to be aware of the potential dangers of combining Oxycontin and carisoprodol?

Many healthcare providers may not fully appreciate the abuse potential and CNS-depressant properties of carisoprodol, compared to the well-known risks of Oxycontin. Increased awareness of the dangers of this drug combination can help prevent serious adverse events, including respiratory depression, coma, and even death. By understanding the risks, providers can make more informed decisions about prescribing these drugs and monitor their patients more closely.

Possible Dangerous Interaction of Oxycontin and Carisoprodol

ROY R. REEVES, D.O., PH.D., AND JAMES E. MACK, PH.D., University of Mississippi School of Medicine, VA Medical Center, 1500 E. Woodrow Wilson Dr., Jackson, MS 39216

Am Fam Physician. 2003;67(11):2273

to the editor: Oxycontin is a time-release-controlled formulation of oxycodone that can be taken every 12 hours for the effective treatment of pain caused by cancer and other types of chronic pain. However, abuse of oxycontin is common; no other prescription drug in the past 20 years has been so widely misused so soon after its release. ¹ Carisoprodol (Soma) is a skeletal muscle relaxant that also has shown potential for abuse.² We report a case of a possible dangerous interaction of Oxycontin and carisoprodol.

A 49-year-old woman received treatment for severe degenerative disease of the lumbar spine with 40 mg of Oxycontin twice daily for over a year. Although she continued to complain of pain and paravertebral muscle spasm, her physician was reluctant to increase the dosage of Oxycontin. One tablet (350 mg) of carisoprodol four times daily was prescribed. After taking this regimen for a week without relief she increased the dosage to eight to 10 tablets a day, assuming this would be safe. Her boyfriend called an ambulance after finding her lying unconscious on the floor and was unable to awaken her.

An examination revealed blood pressure of 130/60 mm Hg and respirations of 14 per minute and decreased in depth. She was responsive only to painful stimuli. Her pupils were small but equal and reactive. She was given 2 mg of naloxone intravenously with rapid return of alertness. A count of her remaining supply of medications verified that she had not taken any extra Oxycontin and a drug screen was negative except for opiates.

The most likely explanation for this patient’s adverse reaction would be a response to the additive depressant effects on the central nervous system (CNS) of both Oxycontin and carisoprodol. Although the effects of Oxycontin are well known in the medical community, many physicians are unaware that cariso-prodol is metabolized to meprobamate (Mil-town), which is a Class IV controlled substance with significant physiologic effects, and has potential for abuse and dependency.³ Previous reports^4,5 have suggested that substance abusers may use carisoprodol to augment or modify the effects of illicit drugs and that combinations of carisoprodol and tramadol (Ul-tram) may have potent psychotropic effects.

Carisoprodol and Oxycontin should only be prescribed concomitantly with extreme caution because of the abuse potential and the potentially dangerous additive CNS-depressant effect of the two drugs. While numerous deaths related to Oxycontin have occurred,¹ it should be noted that a retrospective review⁶ of autopsy cases in Jefferson County, Alabama from January 1, 1986 to October 31, 1997 found carisoprodol present in 24 cases; the reviewers concluded that the drug was probably partly responsible for those deaths.⁶ The interactions of carisoprodol with other CNS depressant drugs appears to be particularly significant. Carisoprodol has been made a controlled substance in the state of Alabama⁶ and may eventually be made a controlled substance in other states or at the federal level.

Email letter submissions to [email protected]. Letters should be fewer than 400 words and limited to six references, one table or figure, and three authors. Letters submitted for publication in AFP must not be submitted to any other publication. Letters may be edited to meet style and space requirements.

This series is coordinated by Kenny Lin, MD, MPH, deputy editor.

Buy Soma (Carisoprodol) Online Without Prescription

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Buy Soma (Carisoprodol) Online Without Prescription

Soma (Carisoprodol)

Soma Carisoprodol is an effective muscle relaxer that blocks pain sensations that reach the brain. Keep reading to learn everything about how to take the medicine. Also, discover its side effects, properties and contraindications.

What is Soma (Carisoprodol)?

Soma belongs to the muscle relaxant class of drugs. It selectively relaxes skeletal muscles and is used for a variety of spastic conditions. With the active ingredient Carisoprodol, Soma works by binding to receptors in the brain that cause pain sensations. The preparation shows promising results to fight skeletal muscle pain when the treatment is usually complemented by physical therapy that includes special exercises. Being approved by FDA in 1959, the medicine is indicated for oral consumption.

Soma has a high habit-forming factor. That is why it is advisable to avoid long-term treatment and increasing a dose without doctor’s approval.Most injuries require short-term treatment. That is why the duration of treatment with centrally acting muscle relaxants is determined by the severity of the patient’s condition and can range from 5-7 days to several weeks or several months.

Before Taking the Drug

Avoid using Soma if you have ever had allergic reactions to the main ingredient or meprobamate. Also, inform your doctor if you experience porphyria is an enzyme disorder (a result of an accumulation of natural chemicals that produce porphyrin in your body).

Also, it is necessary to weigh the risks and benefits of treatment if you have:

• liver problems;
• kidney disease;
• occasional or frequent seizures.

Inform your healthcare provider if you are pregnant since it isn’t studied how the medicine affects the fetus. If Soma is prescribed toa mother, it is a reason to discontinue breastfeeding since the main ingredient may cause drowsiness in a baby.

It isn’t recommended using the medication in those patients who are younger than 16 years old. Besides, elder patients have more chances to experience the negative effects of Carisoprodol.

How to Take Soma?

It is necessary to use Soma (Carisoprodol) based on the recommendations of a medical specialist. You can also learn these tips to have a hassle-free experience during the treatments with Soma.

• Take the medication right as described in your prescription label.
• Don’t share the tablets with other people, even if they suffer from the same symptoms. Soma has a misuse potential and causes addiction.
• It is recommended using Soma 3 times a day and before sleep time.
• Avoid using Soma for more than 2-3 weeks.
• Consult your doctor if you don’t feel better or your conditions have deteriorated.
• Your healthcare provider should recommend to you how to gradually decrease a dose to end the therapy. Immediate refusal from the preparation may cause severe withdrawal symptoms.
• The preparation will have a higher level of efficacy when combined with pain relief therapy and physical exercises.
• Don’t use alcohol when taking Soma since it may result in serious adverse reactions and even fatal consequences.
• Soma produces a sedative and skeletal muscles relaxant effect. Don’t drive a car unless you know how Soma affects your body and mind.
• Soma can exacerbate concomitant mental and neurological diseases in patients such as schizophrenia, epilepsy, Parkinson’s disease, Meniere’s disease (persistent dizziness). Therefore, when using Soma, it is recommended to constantly attend a physician, psychiatrist, or neurologist.

Soma (Carisoprodol) Drug Interactions

You should consult your doctor if you are going to mix any drugs with Soma. Some preparations may reduce the effectiveness of Soma and cause severe adverse effects. It is prohibited to take Soma with sleep drugs and other muscle relaxants since such interaction may be the reason for shortness of breath and coma. Also, avoid using Soma with opioids and anxiety medications.

You can mix Soma with multiple drugs and organic products. Also, it is possible to take the medicine with vitamins and food supplements. However, consult a medical specialist if you experience any side effects.

Possible Adverse Reactions

Go to the emergency room if you are allergic to the main constituent of Soma. Such adverse reactions as skin rash, difficult breathing face, and face/sinus swelling require urgent medical assistance.

Stop using Soma and contact your doctor as soon as possible if you have one or multiple side effects such as:

• imbalanced heart rate;
• muscle stiffness;
• seizure;
• hallucinations;
• severe bloody diarrhea;
• vomiting

The common Soma adverse reactions include:

• moderate and severe headache;
• sleepiness;
• confusion;
• feeling weak and lightheaded.

Don’t use more than prescribed by your healthcare provider since you may overdose. It may have fatal consequences since Soma can slow your breathing. Seek emergency in case you take more than it is prescribed.

Soma can cause a decrease in blood pressure in the patient and, as a result, dizziness, a feeling of weakness. The preparation should be used with extreme caution in persons with arterial hypotension.

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Abuse of the drug can lead to addiction, seizures, coma or death. Somacid is a Mexican brand made in Guadalajara. In Mexico, Soma costs $30 to $35 and Somacid costs $18 to $30 for two 50-tablet bottles. In the US street cost $1 to $5 for a 350mg tablet .

So, can Soma be used for anxiety?

Effects of Soma (Carisoprodol) Carisoprodol causes muscle relaxation, sedation and anxiety reduction .

With this in mind, is carisoprodol discontinued?

Teva has presentations of carisoprodol 350mg tablets in reverse order and the company is estimating release dates in early November 2021. They have a short term product available from expiring 11/2021 .

Also, what is the retail price of soma 350 mg?

1 tablet Carisoprodol 350 mg (approximate cost $10 )

How much soma can be taken at one time?

The recommended dose of SOMA is 250 mg to 350 mg three times a day and at bedtime. The recommended maximum duration of SOMA use is up to two or three weeks.

Second, will Soma help me sleep?

Soma is the only muscle relaxant that really works. Not only does it really “relax” the tension and knots in my muscles, but it can also ease tension headaches, work like a sleeping pill, and reduce my need for opioids with very few side effects.

Contents

Is Robuxin similar to Soma?

Are Robaxin and Soma the same thing? Robaxin (methocarbamol) and Soma ( Carisoprodol ) are muscle relaxants used to treat muscle pain or injury. Similar side effects of robaxin and soma include upset stomach, nausea, vomiting, headache, blurred vision, dizziness, drowsiness, and trouble sleeping (insomnia).

Is Soma illegal in the US?

Yes, Soma misuse illegal . … Soma is not planned at the federal level. However, reports of abuse of soma are monitored by the Drug Enforcement Administration and if necessary, soma can be listed under the Controlled Substances Act.

Which medicine is similar to Soma?

Carisoprodol is the generic equivalent of soma – soma and carisoprodol are the same thing. Other muscle relaxants other than Robaxin and Soma that you may have heard of include Flexeril (cyclobenzaprine), Skelaxin (metaxalone), and Zanaflex (tizanidine).

Is Soma similar to Flexeril?

Are Flexeril and Soma the same thing? Flexeril (Cyclobenzaprine) and Soma ( Carisoprodol ) are muscle relaxants indicated as an adjunct to rest and physical therapy to relieve muscle spasm associated with acute painful musculoskeletal conditions.

What is the highest mg som?

COMA (carisoprodol) tablets are available in 250 mg and 350 mg round, white tablets. Carisoprodol is a white crystalline powder with a slight characteristic odor and a bitter taste.

What is DAN 5513 tablet?

Tablet imprinted 5513 DAN – white, round, labeled Carisoprodol 350 mg . Supplied by Watson Pharmaceuticals. Carisoprodol is used in the treatment of muscle spasm and belongs to a class of drugs that relax skeletal muscles. The risk cannot be excluded during pregnancy.

Is Soma a good muscle relaxant?

Soma (carisoprodol) is muscle relaxant blocks pain between the nerves and the brain. Soma is used along with rest and physical therapy to treat skeletal muscle conditions such as pain or injury.

What is the highest milligram som?

COMA (carisoprodol) tablets are available in 250 mg and 350 mg round, white tablets.

What is the safest muscle relaxant?

Cyclobenzaprine has been rated B by the FDA for safety during pregnancy, making it the safest muscle relaxant to use during pregnancy. Dantrolene (Dantrium). Dantrolene helps control chronic spasticity associated with spinal injuries. It is also used for conditions such as stroke, multiple sclerosis, and cerebral palsy.

Which muscle relaxant is closest to Soma?

Which muscle relaxant is the same as Soma? Carisoprodol is the generic equivalent of soma – soma and carisoprodol are the same thing. Other muscle relaxants other than Robaxin and Soma that you may have heard of include Flexeril (cyclobenzaprine), Skelaxin (metaxalone), and Zanaflex (tizanidine).

Does Soma appear on a drug test?

Soma may show up in urinalysis within a few days after last dose . In people who chronically use Soma, it can be detected in the urine even longer. In a blood test, Soma may appear about 24 hours after someone has taken a dose. In a hair test, Soma can appear up to a month after someone has used it.

Why was Robaxin discontinued?

Par discontinued methocarbamol tablets in July 2018. Solco says shortage was due to lack of active ingredient .

Robaxin – a powerful muscle relaxer?

Robaxin and Flexeril, which are also classified as antispasmodics, are effective in the treatment of acute painful musculoskeletal disorders that cause discomfort and muscle spasms.
…
Flexeril.

• April 28, 2020

Which muscle relaxant is closest to Soma?

Which muscle relaxant is the same as Soma? Carisoprodol is the generic equivalent of soma – soma and carisoprodol are the same thing. Other muscle relaxants other than Robaxin and Soma that you may have heard of include Flexeril (cyclobenzaprine), Skelaxin (metaxalone), and Zanaflex (tizanidine).

Will Soma show up for a drug test?

Soma could show up in the urinalysis within a few days after the last dose of . In people who chronically use Soma, it can be detected in the urine even longer. In a blood test, Soma may appear about 24 hours after someone has taken a dose.

Is carisoprodol a benzo?

The half-life of carisoprodol is approximately 2.4 hours. Meprobamate is considered an active metabolite and also has a sedative effect like a benzodiazepine. But in terms of toxicity, it is more like the sedative properties of barbiturates.

What is the strongest natural muscle relaxation?

1. Chamomile . Chamomile is an ancient herb that is used to treat a variety of ailments, including muscle spasms. It contains 36 flavonoids that have anti-inflammatory properties.

Why is Flexeril no longer available?

Tricyclic antidepressants have been reported to cause arrhythmias, sinus tachycardia, and prolong conduction time leading to myocardial infarction and stroke.” Due to the insight of a pharmacist, Flexeril was discontinued and baclofen was prescribed instead.

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