What is carisoprodol used for? How should it be dosed? What are the precautions and potential interactions to be aware of? Get the answers to these and other key questions about this muscle relaxant medication.

Understanding Carisoprodol: An Overview

Carisoprodol is a muscle relaxant medication primarily used for the relief of discomfort associated with acute, painful musculoskeletal conditions. It works by reducing muscle spasms and pain, allowing for improved mobility and functionality. This drug is intended for short-term use, as prolonged usage lacks sufficient evidence of effectiveness.

Carisoprodol Dosage and Usage

The usual adult dose of carisoprodol for muscle spasm is 250 to 350 mg taken orally three times a day and at bedtime. The duration of therapy should be limited to 2 to 3 weeks, as there is inadequate evidence to support prolonged use.

Carisoprodol Dose Adjustments

Certain patient populations may require dose adjustments of carisoprodol:

• Patients with Reduced CYP450 2C19 Activity: Use carisoprodol with caution, as higher exposure to carisoprodol and lower exposure to its active metabolite, meprobamate, may occur. The clinical significance of this is not well-established.
• Renal and Hepatic Impairment: Carisoprodol should be used with caution in patients with renal or hepatic impairment.

Precautions and Warnings with Carisoprodol

Carisoprodol use carries several important precautions and warnings:

• Safety and efficacy have not been established in patients younger than 16 years or older than 65 years.
• Carisoprodol is a US Controlled Substance, classified as Schedule IV, due to its potential for dependence, withdrawal, and abuse.
• Patients should avoid engaging in potentially hazardous activities, such as driving, after taking carisoprodol, as it can cause sedation.
• Concomitant use of alcohol or other central nervous system (CNS) depressants should be avoided.
• Patients should be informed of the risks of dependence, withdrawal, and abuse associated with prolonged use of carisoprodol, which should be limited to less than 3 weeks.

Carisoprodol Dialysis and Other Considerations

Carisoprodol is dialyzable by both peritoneal and hemodialysis. Monitoring for sedation and signs of abuse or overdose is recommended during treatment.

Carisoprodol Interactions

Carisoprodol has a significant potential for drug interactions, with 362 known interactions, including 27 major, 334 moderate, and 1 minor interactions. Some of the most frequently checked interactions include:

• Major Interactions: Adderall (amphetamine/dextroamphetamine), Ambien (zolpidem), Fentanyl Transdermal System (fentanyl), Flexeril (cyclobenzaprine), Norco (acetaminophen/hydrocodone), OxyContin (oxycodone), Xanax (alprazolam)
• Moderate Interactions: Advair Diskus (fluticasone/salmeterol), Aspirin Low Strength (aspirin), Benadryl (diphenhydramine), Celebrex (celecoxib), Cymbalta (duloxetine), Lexapro (escitalopram), Lyrica (pregabalin), Metoprolol Succinate ER (metoprolol), Metoprolol Tartrate (metoprolol), Morphine Sulfate ER (morphine), Nexium (esomeprazole), ProAir HFA (albuterol), Seroquel (quetiapine), Singulair (montelukast), Synthroid (levothyroxine), Vicodin (acetaminophen/hydrocodone), Vitamin B12 (cyanocobalamin), Vitamin C (ascorbic acid), Vitamin D2 (ergocalciferol), Vitamin D3 (cholecalciferol), Zyrtec (cetirizine)
• Alcohol/Food Interaction: Carisoprodol should be used with caution when consuming alcohol.
• Disease Interactions: Carisoprodol should be used with caution in patients with porphyria.

Frequently Asked Questions

What is carisoprodol used for?
Carisoprodol is primarily used for the relief of discomfort associated with acute, painful musculoskeletal conditions. It works as a muscle relaxant to reduce muscle spasms and pain.

How long can carisoprodol be taken?
The duration of carisoprodol therapy should be limited to 2 to 3 weeks, as there is inadequate evidence to support prolonged use.

Does carisoprodol interact with other medications?
Yes, carisoprodol has a significant potential for drug interactions, with 362 known interactions, including 27 major, 334 moderate, and 1 minor interactions. Patients should inform their healthcare providers of all medications they are taking to avoid potential interactions.

What are the precautions and warnings associated with carisoprodol?
Carisoprodol use carries several important precautions and warnings, including: limited safety and efficacy data in certain age groups, potential for dependence and abuse, sedation that can impact activities like driving, and the need to avoid concomitant use of alcohol or other central nervous system depressants.

Carisoprodol Dosage Guide + Max Dose, Adjustments

Print

Save

Medically reviewed by Drugs.com. Last updated on Mar 20, 2023.

Applies to the following strengths: 350 mg; 250 mg

Usual Adult Dose for:

• Muscle Spasm

Additional dosage information:

• Renal Dose Adjustments
• Liver Dose Adjustments
• Dose Adjustments
• Precautions
• Dialysis
• Other Comments

Usual Adult Dose for Muscle Spasm

250 to 350 mg orally 3 times a day and at bedtime
Duration of therapy: Up to 2 to 3 weeks

Comments:

• This drug should only be used for short periods (up to 2 or 3 weeks) as there is inadequate evidence of effectiveness for more prolonged use and acute, painful musculoskeletal conditions are generally of short duration.

Use: For the relief of discomfort associated with acute, painful musculoskeletal conditions

Renal Dose Adjustments

Use with caution

Liver Dose Adjustments

Use with caution

Dose Adjustments

Patients with Reduced CYP450 2C19 Activity:

• Use with caution as higher exposure to carisoprodol and lower exposure to meprobamate (active metabolite) is expected; the clinical significance of this is not known.

Precautions

Safety and efficacy have not been established in patients younger than 16 years or over 65 years.

US Controlled Substance: Schedule IV

Dialysis

Dialyzable by peritoneal and hemodialysis.

Other Comments

Administration advice:
Take orally with or without food

General:

• Dependence, withdrawal, and abuse have been reported with prolonged use; duration of use should be limited to less than 3 weeks.

Monitoring:

• Monitor for sedation
• Monitor for signs of abuse and overdose

Patient advice:

• Patients should avoid taking this drug prior to engaging in potentially hazardous activities as this drug has been associated with motor vehicle accidents.
• Patients should avoid alcohol while on this drug and check with their healthcare provider before taking other CNS depressants.
• Patients should be informed that this drug has been associated with cases of dependence, withdrawal, and abuse; use should be limited to less than 3 weeks duration.

Frequently asked questions

• What is Caridoxen used for?

More about carisoprodol

• Check interactions
• Compare alternatives
• Pricing & coupons
• Reviews (298)
• Drug images
• Side effects
• Patient tips
• During pregnancy
• Support group
• Drug class: skeletal muscle relaxants
• Breastfeeding
• En español

Patient resources

• Drug Information

Other brands

Soma, Vanadom

Professional resources

• Prescribing Information

Related treatment guides

• Muscle Spasm
• Nocturnal Leg Cramps

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Carisoprodol Interactions Checker – Drugs.com

Print

Save

There are 362 drugs known to interact with
carisoprodol, along with
3 disease interactions, and 1 alcohol/food interaction.

Of the total drug interactions,
27 are major, 334 are moderate, and 1 is minor.

Does carisoprodol interact with my other drugs?

Enter other medications to view a detailed report.

• View all 362 medications that may interact with carisoprodol
• View carisoprodol alcohol/food interactions (1)
• View carisoprodol disease interactions (3)

Most frequently checked interactions

View interaction reports for carisoprodol and the medicines listed below.

• Major
• Moderate
• Minor
• Unknown

• Adderall (amphetamine / dextroamphetamine)
• Advair Diskus (fluticasone / salmeterol)
• Ambien (zolpidem)
• Aspirin Low Strength (aspirin)
• Benadryl (diphenhydramine)
• Celebrex (celecoxib)
• Crestor (rosuvastatin)
• Cymbalta (duloxetine)
• Fentanyl Transdermal System (fentanyl)
• Fish Oil (omega-3 polyunsaturated fatty acids)
• Flexeril (cyclobenzaprine)
• Lexapro (escitalopram)
• Lyrica (pregabalin)
• Metoprolol Succinate ER (metoprolol)
• Metoprolol Tartrate (metoprolol)
• Morphine Sulfate ER (morphine)
• Nexium (esomeprazole)
• Norco (acetaminophen / hydrocodone)
• OxyContin (oxycodone)
• ProAir HFA (albuterol)
• Seroquel (quetiapine)
• Singulair (montelukast)
• Synthroid (levothyroxine)
• Vicodin (acetaminophen / hydrocodone)
• Vitamin B12 (cyanocobalamin)
• Vitamin C (ascorbic acid)
• Vitamin D2 (ergocalciferol)
• Vitamin D3 (cholecalciferol)
• Xanax (alprazolam)
• Zyrtec (cetirizine)

Carisoprodol alcohol/food interactions

There is 1 alcohol/food interaction with carisoprodol.

Carisoprodol disease interactions

There are 3 disease interactions with carisoprodol which include:

• porphyria
• drug dependence
• renal/liver disease

Report options

Loading…

QR code containing a link to this page

More about carisoprodol

• carisoprodol consumer information
• Compare alternatives
• Pricing & coupons
• Reviews (298)
• Drug images
• Side effects
• Dosage information
• Patient tips
• During pregnancy
• Support group
• Drug class: skeletal muscle relaxants
• Breastfeeding
• En español

Related treatment guides

• Muscle Spasm
• Nocturnal Leg Cramps

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.

Major	Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate	Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor	Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown	No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Substance list

90. Carisoprodol

Sources:

– Mathias B. Forrester, Carisoprodol abuse in Texas, 1998–2003, J Med Toxicol. 2006 Mar; 2(1): 8–13. doi: 10.1007/BF03161006

– Reeves, R. R., Pinkofsky, H. B., & Carter, O. S. (1997). Carisoprodol: A drug of continued abuse. The Journal of the American Osteopathic Association, 97(12), 723. doi:10.7556/jaoa.1997.97.12.723

– Mayank Gupta, Case Report: Carisoprodol Abuse in Adolescence, Cureus 12(11): e11525, DOI: 10.7759/cureus.11525

Additional sources:

https://www.drugsdata.org/view.php?id=9454

Active ingredient: Carisoprodol

Nomenclature name: 2-[(Carbamoyloxy)methyl]- 2-methylpentyl propan-2-ylcarbamate

Molecular formula: C12h34N2O4

Molecular weight: 260.33

Initiator/Territorial unit: USA

Russian Federation: Carisoprod traffic control ola is not installed.

Republic of Belarus: control over the circulation of Carisoprodol has not been established.

Substance control status shown corresponds to the date the alert was created.

Carisoprodol, a uniquely structured psychoactive drug, a muscle relaxant sold under the trade name Soma, is used to treat musculoskeletal pain following sprains and muscle injuries. Refers to GABAergic drugs (neurotransmitter of GABA receptors). Carisoprodol is a modification of meprobamate, the “classic” controlled substance. Unlike meprobamate, it has better muscle relaxation properties, it actually acts as a “prodrug”. A significant proportion of carisoprodol is metabolized to meprobamate, which after administration reaches higher peak plasma levels than carisoprodol itself. This largely explains the high abuse potential of carisoprodol.

Carisoprodol, like meprobamate, can cause physical dependence similar to barbiturate after periods of prolonged use. The combination of carisoprodol with opioids and benzodiazepines is referred to as the “Holy Trinity” because it is reported to increase the strength and duration of euphoria. Because of its potentiating action when taken with narcotics, carisoprodol is often abused along with many opioid drugs. The combined use of carisoprodol with other GABAergic drugs, including alcohol, as well as with sedatives in general, poses a significant risk of overdose to the user.

Recently, for example, cases of falsification of Tramadol preparations by carisoprodol have become more frequent. So in December 2020, within the framework of the EcstasyData project, a white tablet with a separating notch, weighing 595 mg, and 12.8 mm x 4.2 mm in size, declared as a tablet with tramadol as the main ADV, was received for research. Analysis of the sample showed the presence of carisoprodol in its composition. Tramadol was not found in the composition.

Monitoring of the distribution of such objects continues.

Operator: YL

/ Listing date: 07.12.2020

Carisoprodol oral: uses, side effects, interactions and images of tablets

• Brand names): Soma

900 02 The display and use of drug information on this site is subject to explicit operating conditions. By continuing to view drug information, you agree to be bound by these Terms of Use.

side effects of montelukast soda 10 mg

• QLT25820: This medicine is a white round tablet labeled “2410 V”.
• VEN07000: This medicine is a white round tablet labeled “SG 109”.
• SEI04750: This medicine is a white round tablet labeled “5513” and “DAN”.
• RSG01740: This medicine is a white round tablet labeled “CL 022”.
• SUN04460: This medicine is a white round tablet labeled “446”.
• OXP01110: This medicine is a white round tablet labeled “111” and “logo”.
• VEN04340: This medicine is a white round tablet labeled “S 434”.
• NRT05100: This medicine is a white round tablet labeled “OP 35”.
• WLL59010: This medicine is a white round tablet labeled “WP 5901”.
• AUR01580: This medicine is a white round tablet labeled “D” and “31”.
• WWW11760: This medicine is a white round tablet labeled “WW 176”.

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT contain all information possible about this product. This information does not guarantee that this product is safe, effective or suitable for you. This information does not constitute individual medical advice and does not replace the advice of your healthcare professional. Always ask your healthcare professional for complete information about this product and your specific medical needs.

Carisoprodol is used short-term to treat muscle pain and discomfort. It is usually used in conjunction with rest, physical therapy, and other treatments. It works by helping to relax the muscles.

Take this medicine by mouth with or without food as directed by your doctor. Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve faster, and the risk of side effects will increase. The dosage depends on your medical condition and response to treatment. This medicine should only be used short-term (for 3 weeks or less) unless directed by your doctor. If you suddenly stop using this medicine, you may experience withdrawal symptoms (eg, stomach cramps, trouble sleeping, headache, nausea). To prevent withdrawal symptoms, the doctor may gradually reduce the dose. Withdrawal is more likely if you have been using carisoprodol for a long time or at high doses. Tell your doctor or pharmacist immediately if you experience withdrawal symptoms. Although this medicine helps many people, sometimes this medicine can be habit-forming. This risk may be higher if you have a substance use disorder (such as drug/alcohol overuse or addiction). Take this medicine exactly as directed to reduce the risk of addiction. For more information, ask your doctor or pharmacist. Tell your doctor if your condition persists after 2 to 3 weeks or worsens.

Dizziness, drowsiness or headache may occur. If any of these effects persist or worsen, tell your doctor or pharmacist immediately. Remember that your doctor prescribed this medicine because he or she felt that the benefit to you was greater than the risk of side effects. Many people who take this medicine do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: confusion. Very serious allergic reactions to this drug are rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, difficulty breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the USA, ask your doctor for medical advice about side effects. You can report side effects to the FDA at 1-800-FDA-1088 or go to www.fda.gov/medwatch. In Canada, call your doctor for medical advice about side effects. You can report side effects to Health Canada at 1-866-234-2345.

Before taking carisoprodol, tell your doctor or pharmacist if you are allergic to it; or meprobamate, tibamate or mebutamat; or if you have other allergies. This product may contain inactive ingredients that may cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medicine, tell your doctor or pharmacist your medical history, especially: a certain blood disorder (acute intermittent porphyria), kidney disease, liver disease, seizures, personal or family history of the substance. use disorder (eg, excessive use or addiction to drugs/alcohol). This drug may make you dizzy or drowsy. Alcohol or marijuana (cannabis) can make you dizzy or drowsy. Do not drive, use machinery, or do anything that requires vigilance until you know how to do it safely. Avoid alcoholic drinks. If you use marijuana (cannabis), talk to your doctor. Before surgery, tell your doctor or dentist about all products you use (including prescription drugs, over-the-counter drugs, and herbal products). Older people may be more sensitive to the sides. the effects of this drug, especially drowsiness or confusion. These side effects may increase your risk of falling. During pregnancy, this medication should only be used if absolutely necessary. Discuss the risks and benefits with your doctor. This medicine passes into breast milk and may have undesirable effects on a nursing baby. Consult your doctor before breastfeeding.

Drug interactions may change how your drugs work or increase the risk of serious side effects. This document does not contain all possible drug interactions. Make a list of all the products you use (including prescription/OTC drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medication without your doctor’s approval. Tell your doctor or pharmacist if you are taking other products that cause drowsiness, such as opioid pain or cough medicines (eg, codeine, hydrocodone), alcohol, marijuana (cannabis), sleep or anxiety medicines (eg, alprazolam, lorazepam, zolpidem), other muscle relaxants (eg, cyclobenzaprine, methocarbamol), or antihistamines (eg, cetirizine, diphenhydramine). Check the labels on all your medicines (such as allergy or cough medicines) as they may contain ingredients that cause drowsiness. Ask your pharmacist about the safe use of these products.

If someone has overdosed and has serious symptoms such as fainting or difficulty breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Residents of Canada can call their provincial poison control center. Overdose symptoms may include: severe drowsiness/dizziness, convulsions, slow/shallow breathing, mental/mood changes (eg, confusion, hallucinations), inability to move legs/arms, wobbly/unsteady movement, vision changes (eg, blurred vision. ).

Do not give this medicine to other people. It’s against the law. This medicine has only been prescribed for your current condition. Do not use it later for another condition unless your doctor tells you to. In this case, another medicine may be needed.