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What is d ribose used for: The request could not be satisfied

Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Ataka, S., Tanaka, M., Nozaki, S., Mizuma, H., Mizuno, K., Tahara, T., Sugino, T., Shirai, T., Kajimoto, Y., Kuratsune, H., Kajimoto, O., and Watanabe, Y. Effects of oral administration of caffeine and D-ribose on mental fatigue. Nutrition 2008;24(3):233-238. View abstract.

Earnest, C. P., Morss, G. M., Wyatt, F., Jordan, A. N., Colson, S., Church, T. S., Fitzgerald, Y., Autrey, L., Jurca, R., and Lucia, A. Effects of a commercial herbal-based formula on exercise performance in cyclists. Med Sci Sports Exerc. 2004;36(3):504-509. View abstract.

Gilula, M. F. Cranial electrotherapy stimulation and fibromyalgia. Expert.Rev.Med Devices 2007;4(4):489-495. View abstract.

Gunning, M. G., Clunie, G., Bradley, J., Gupta, N. K., Bomanji, J. B., and Ell, P. J. Slow bolus injection of ribose in the identification of thallium-201 redistribution following combined adenosine/dynamic exercise stress. Eur.Heart J 1996;17(9):1438-1443. View abstract.

Hellsten, Y., Skadhauge, L., and Bangsbo, J. Effect of ribose supplementation on resynthesis of adenine nucleotides after intense intermittent training in humans. Am.J Physiol Regul.Integr.Comp Physiol 2004;286(1):R182-R188. View abstract.

Kendler, B. S. Supplemental conditionally essential nutrients in cardiovascular disease therapy. J Cardiovasc.Nurs. 2006;21(1):9-16. View abstract.

MacCarter, D., Vijay, N., Washam, M., Shecterle, L., Sierminski, H., and St Cyr, J. A. D-ribose aids advanced ischemic heart failure patients. Int J Cardiol. 9-11-2009;137(1):79-80. View abstract.

Pauly, D. F. and Pepine, C. J. D-Ribose as a supplement for cardiac energy metabolism. J Cardiovasc.Pharmacol.Ther. 2000;5(4):249-258. View abstract.

Quinlivan, R. M. and Beynon, R. J. Pharmacological and nutritional treatment trials in McArdle disease. Acta Myol. 2007;26(1):58-60. View abstract.

Salerno, C., D’Eufemia, P. , Finocchiaro, R., Celli, M., Spalice, A., Iannetti, P., Crifo, C., and Giardini, O. Effect of D-ribose on purine synthesis and neurological symptoms in a patient with adenylosuccinase deficiency. Biochim.Biophys.Acta 1-6-1999;1453(1):135-140. View abstract.

Sawada, S. G., Lewis, S., Kovacs, R., Khouri, S., Gradus-Pizlo, I., St Cyr, J. A., and Feigenbaum, H. Evaluation of the anti-ischemic effects of D-ribose during dobutamine stress echocardiography: a pilot study. Cardiovasc.Ultrasound 2009;7:5. View abstract.

Shecterle, L., Kasubick, R., and St, Cyr J. D-ribose benefits restless legs syndrome. J Altern.Complement Med 2008;14(9):1165-1166. View abstract.

Zimmer, H. G., Ibel, H., Suchner, U., and Schad, H. Ribose intervention in the cardiac pentose phosphate pathway is not species-specific. Science 2-17-1984;223(4637):712-714. View abstract.

Berardi JM, Ziegenfuss TN. Effects of ribose supplementation on repeated sprint performance in men. J Strength Cond Res 2003;17:47-52. View abstract.

Burke ER. D-Ribose What You Need To Know. Garden City Park, NY: Avery Publishing Group 1999;1-43.

Chatham JC, John Challiss RA, Radda GK, et al. Studies of the protective effect of ribose in myocardial ischaemia by using P31-nuclear-magnetic-resonance spectroscopy. Biochem Soc Trans 1985;13:885-6.

Derosa G, Pasqualotto S, Catena G, D’Angelo A, Maggi A, Maffioli P. A randomized, double-blind, placebo-controlled study to evaluate the effectiveness of a food supplement containing creatine and D-ribose combined with a physical exercise program in increasing stress tolerance in patients with ischemic heart disease. Nutrients 2019;11(12):3075. View abstract.

Dunne L, Worley S, Macknin M. Ribose versus dextrose supplementation, association with rowing performance: a double-blind study. Clin J Sport Med 2006;16:68-71. View abstract.

EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA). Statement on the safety of d-ribose. EFSA J 2018;16(12):e05485. View abstract.

Falk DJ, Heelan KA, Thyfault JP, Koch AJ. Effects of effervescent creatine, ribose, and glutamine supplementation on muscular strength, muscular endurance, and body composition. Strength Cond Res 2003;17:810-6. View abstract.

Foker JE, Einzig S, Wang T. Adenosine metabolism and myocardial preservation. Consequences of adenosine catabolism on myocardial high-energy compounds and tissue blood flow. J Thorac Cardiovasc Surg 1980;80:506-16. View abstract.

Fox IH, Kelley WN. Phosphoribosylpyrophosphate in man: biochemical and clinical significance. Ann Intern Med 1971;74:424-33. View abstract.

Geisbuhler TP, Schwager TL. Ribose-enhanced synthesis of UTP, CTP, and GTP from parent nucleosides in cardiac myocytes. J Mol Cell Cardiol 1998;30:879-87. View abstract.

Gross M, Reiter S, Zollner N. Metabolism of D-ribose administered continuously to healthy persons and to patients with myoadenylate deaminase deficiency. Klin Wochenschr 1989;67:1205-13. View abstract.

Hegewald MG, Palac RT, Angello DA, et al. Ribose infusion accelerates thallium redistribution with early imaging compared with late 24-hour imaging without ribose. J Am Coll Cardiol 1991;18:1671-81. View abstract.

Hellsten-Westing Y, Norman B, Balsom PD, et al. Decreased resting levels of adenine nucleotides in human skeletal muscle after high-intensity training. J Appl Physiol 1993;74:2523-8. View abstract.

Kerksick C, Rasmussen C, Bowden R, et al. Effects of ribose supplementation prior to and during intense exercise on anaerobic capacity and metabolic markers. Int J Sport Nutr Exerc Metab 2005;15:653-64. View abstract.

Kreider RB, Melton C, Greenwood M, et al. Effects of oral D-ribose supplementation on anaerobic capacity and selected metabolic markers in healthy males. Int J Sport Nutr Exerc Metab 2003;13:76-86. View abstract.

Muller C, Zimmer HG, Gross M, et al. Effect of ribose on cardiac adenine nucleotides in a donor model for heart transplantation. Eur J Med Res 1998;3:554-8. View abstract.

Omran H, Illien S, MacCarter D, et al. D-Ribose improves diastolic function and quality of life in congestive heart failure patients: a prospective feasibility study. Eur J Heart Fail 2003;5:615-9. View abstract.

Op ‘t Eijnde B, Van Leemputte M, Brouns F, et al. No effects of oral ribose supplementation on repeated maximal exercise and de novo ATP resynthesis. J Appl Physiol 2001;91:2275-81. View abstract.

Pasque MK, Spray TL, Pellom GL, et al. Ribose-enhanced myocardial recovery following ischemia in the isolated working rat heart. J Thorac Cardiovasc Surg 1982;83:390-8. View abstract.

Pasque MK, Wechsler AS. Metabolic intervention to affect myocardial recovery following ischemia. Ann Surg 1984;200:1-12. View abstract.

Perkowski D, Wagner S, Marcus A, St. Cyr J. Ribose enhances ventricular function following off pump coronary artery bypass surgery. J Altern Complement Med 2005;11:745.

Perlmutter NS, Wilson RA, Angello DA, et al. Ribose facilitates thallium-201 redistribution in patients with coronary artery disease. J Nucl Med 1991;32:193-200. View abstract.

Peveler WW, Bishop PA, Whitehorn EJ. Effects of ribose as an ergogenic aid. J Strength Cond Res 2006;20:519-22. View abstract.

Pliml W, von Arnim T, Stalein A, et al. Effects of ribose on excercise-induced ischaemia in stable coronary artery disease. Lancet 1992;340:507-10. View abstract.

Segal S, Foley J. The metabolism of D-ribose in man. J Clin Invest 1958;37:719-35.

Seifert JG, Brumet A, St Cyr JA. The influence of D-ribose ingestion and fitness level on performance and recovery. J Int Soc Sports Nutr. 2017 Dec 20;14:47. View abstract.

Seifert JG, Subudhi AW, Fu MX, et al. The role of ribose on oxidative stress during hypoxic exercise: a pilot study. J Med Food 2009;12(3):690-3. View abstract.

St Cyr JA, Bianco RW, Schneider JR, et al. Enhanced high energy phosphate recovery with ribose infusion after global myocardial ischemia in a canine model. J Surg Res 1989;46:157-62. View abstract.

Stathis CG, Febbraio MA, Carey MF, et al. Influence of sprint training on human skeletal muscle purine nucleotide metabolism. J Appl Physiol 1994;76:1802-9. View abstract.

Steele IC, Patterson VH, Nicholls DP. A double blind, placebo controlled, crossover trial of D-ribose in McArdle’s disease. J Neurol Sci 1996;136:174-7. View abstract.

Teitelbaum JE, Johnson C, St Cyr J. The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study. J Altern Complement Med 2006;12:857-62. View abstract.

Thompson J, Neutel J, Homer K, Tempero K, Shah A, Khankari R. Evaluation of D-ribose pharmacokinetics, dose proportionality, food effect, and pharmacodynamics after oral solution administration in healthy male and female subjects. J Clin Pharmacol 2014;54(5):546-54. View abstract.

Tullson PC, Bangsbo J, Hellsten Y, et al. IMP metabolism in human skeletal after exhaustive exercise. J Appl Physiol 1995;78:146-52. View abstract.

Wagner DR, Felbel J, Gresser U, et al. Muscle metabolism and red cell ATP/ADP concentration during bicycle ergometer in patients with AMPdeficiency. Klin Wochenschr 1991;69:251-5. View abstract.

Wagner DR, Gresser U, Zollner N. Effects of oral ribose on muscle metabolism during bicycle ergometer in AMPD-deficient patients. Ann Nutr Metab 1991;35:297-302. View abstract.

Ward HB, St Cyr JA, Cogordan JA. Recovery of adenine nucleotide levels after global myocardial ischemia in dogs. Surgery 1984;96:248-55. View abstract.

Zollner N, Reiter S, Gross M, et al. Myoadenylate deaminase deficiency: successful symptomatic therapy by high dose oral administration of ribose. Klin Wochenschr 1986;64:1281-90. View abstract.

Benefits, Side Effects, Dosage, and Interactions

Ribose is a sugar molecule that occurs naturally in the body and is made from blood glucose. It is a key component of adenosine triphosphate (ATP)—a molecule involved in storing and releasing energy, muscle contraction, and nerve impulse propagation—and ribonucleic acid (RNA), a molecule involved in protein synthesis and other cell activities. Also known as D-ribose, it is sold as a nutritional supplement to reduce fatigue and improve athletic performance. The synthetic form of this supplement is called N-ribose.

Ribose shows some promise as a treatment for people with energy deficits, such as chronic fatigue syndrome and fibromyalgia, and is popular among athletes looking to increase energy, boost stamina, and enhance athletic performance.

Health Benefits


Despite ribose’s potential benefits, there is limited scientific evidence to support its use for any health condition or performance enhancement. Here’s a look at some key findings from the available research on ribose supplements:

Fibromyalgia and Chronic Fatigue

D-ribose shows promise in the treatment of fibromyalgia and myalgic encephalomyelitis, better known as chronic fatigue syndrome (CFS or ME-CFS). A 2017 review of dietary modifications for chronic fatigue patients reports that D-ribose supplementation significantly improved energy levels and overall mood.

In a pilot study published in the Journal of Alternative and Complementary Medicine, 41 patients with fibromyalgia and/or chronic fatigue syndrome who were given ribose supplements, 66 percent of the patients showed significant improvement in symptoms such as lack of energy, difficulty sleeping, and pain.

Both fibromyalgia and chronic fatigue syndrome are marked by impaired energy metabolism. The study’s authors suggest that ribose may help treat the two conditions by increasing the production of energy in the heart and muscles. However, more research is needed.

Athletic Performance

Although ribose supplements are widely touted as a natural remedy for enhancing exercise endurance, two small studies—one published in the International Journal of Sport Nutrition and Exercise Metabolism and the other published in the Journal of Applied Physiology in 2001—failed to find supporting evidence and suggest that ribose supplements may have no effect on athletic performance.

Heart Failure Recovery

Ribose supplements may be of some benefit to heart failure patients. In a 2015 study, Ohio State University researchers gave a small sample of congestive heart failure (CHF) patients 5 grams of D-ribose daily for six weeks. Measurements of heart function improved in 64 percent of subjects, and those improvements were sustained in follow-up assessments three weeks after ceasing supplementation.

Earlier research published in the European Journal of Heart Failure found D-ribose supplements enhanced the quality of life and improved certain measures of cardiac function in CHF patients. In the study, 15 patients were given either D-ribose or a placebo daily for three weeks, then after a one-week break patients were switched over to the alternate treatment for another three weeks.

While the research is promising, it is limited to small sample sizes and animal studies.

The American College of Cardiology Foundation and American Heart Association’s 2013 CHF practice guidelines do not recommend nutritional supplements in the treatment of CHF.

Possible Side Effects

D-ribose is generally considered safe for short-term use. However, possible side effects include diarrhea, stomach discomfort, nausea, headache, and low blood sugar.

People who have diabetes and are taking blood-glucose-lowering medications, such as insulin or sulfonylureas, and patients with hypoglycemia should avoid supplementing with D-ribose, as it may lower blood sugar.

If you are having surgery, do not take D-ribose. It is recommended to stop supplementation at least two weeks prior to scheduled surgery, as the supplement may make it difficult to maintain blood sugar levels.

There is not enough evidence to support its safety during pregnancy and breastfeeding, and it is not recommended for use at those times.

Verywell / Anastasia Tretiak

Dosage and Preparation


Ribose is sold as both ribose and D-ribose in capsules and powder. Since it is a naturally occurring sugar, it tastes sweet. The powder can be mixed with water or juice and can be used to make beverages like lemonade.

There is no standard recommended dosage of D-ribose. Based on scientific studies, alternative health practitioners recommend between 5 grams and 30 grams a day to support chronic health conditions. As a workout enhancer, 5 grams a day is the common dose.

What to Look For


When selecting a brand of supplements, look for products that have been certified by ConsumerLabs, the U.S. Pharmacopeia, or NSF International.

Other Questions


Will D-ribose raise my blood sugar?

Ribose is a naturally occurring sugar, but it does not impact blood sugar the same as sucrose or fructose. Some research suggests ribose may increase insulin production, resulting in lower blood sugar levels, hence the restrictions for use in those with hypoglycemia or who are taking related medications.

Will ribose help me gain muscle?

There is limited to research to suggest that ribose improves athletic performance, but it is still a popular supplement for fitness enthusiasts. On its own, it will not increase muscle mass. However, it may help you be less sore between workouts.

A Word From Verywell 

Due to the limited research, it’s too soon to recommend D-ribose supplements for any condition. It’s also important to note that self-treating a condition and avoiding or delaying standard care may have serious consequences. If you’re considering the use of D-ribose supplements in the treatment of any chronic condition, talk to your doctor before starting your supplement regimen.

‘D-RIBOSE’ – it’ll knock your socks off!

There’s an amazing new supplement on the market and it’s called ‘D-Ribose’. Amazing – why? I’ve spent the last 18 months carefully examining the literature and reading every morsel of information I can find on the subject – and it appears that this little sugar will allow you to train harder, for longer and recover 300-400% quicker!!! Hence, the emergence of TORQ ribose and TORQ bar. Most of my riders have been using TORQ ribose over the winter months and have found it highly effective during periods of heavy high load training and ensuring a peak for races. If you find these claims difficult to accept, read on and I’ll convince you. There are many supplements out there that manufacturers claim will work, but don’t – this certainly isn’t one of them…

Ribose is present within every living cell of the body and is used to manufacture ATP (the energy currency of the cell) from scratch. Whilst the body can manufacture its own ribose from glucose, this requires energy and is a very slow process. Research into ribose supplementation* has proven that taking as little as 3-5grams per day will return cellular levels of ATP to normal within 6-22 hours of exhaustive exercise. Without supplementation, this is likely to take between 26 and 93 hours.

Ribose has only recently become commercially available and in the coming years I suspect that it will be as talked about among endurance athletes as creatine currently is with the strength/power performer. Ribose is the precursor to ATP (energy) production in the cell. Whereas creatine quickly recycles ADP + Pi to make ATP, ribose is actually used to manufacture ATP from scratch. The benefits of creatine, carbohydrate or any other nutrient will be seriously hampered if cellular ATP, ADP and AMP are low – and ribose is the only solution. Either wait for your body to manufacture its own or take a fast-acting supplement, the choice is yours…

Every cell in your body contains ATP (adinosine triphosphate), an energy-rich compound that provides virtually all the energy needed to function on a second-by-second basis. When ATP is broken down into ADP + Pi (adinosine diphosphate + inorganic phosphate) energy is released and this is used to power all our bodily functions. Naturally then, it is the breakdown of ATP within the cells of the working muscles that provides the energy for exercise. Without it you wouldn’t be going anywhere!

It is through the metabolism of carbohydrate, fat and protein that ADP + Pi is reformed to make ATP. This ATP is then available to be used for muscular contraction. As the muscle uses it, once again it will break down to ADP + Pi and so it goes on. When exercising, this cycle rapidly and continually takes place in order to satisfy the substantial turnover of energy required.

Research has shown that after maximal high load exercise, the pools of ATP and ADP + Pi in skeletal muscle cells are reduced by as much as 20-28 percent. The mechanisms behind this are rather complex and involve the loss of a compound called AMP (adinosine monophosphate). However, the net effect is that the overall pools of ATP and ADP + Pi within each cell is reduced, which seriously limits their energy potential. It doesn’t matter how much carbohydrate you ram into your body, if these nucleotide levels are low, you’re not going to have the raw materials available to exercise effectively. To further compound the problem, once AMP has left the cell, there’s no getting it back and so ATP and ADP + Pi levels will remain low, perhaps sinking further if another high intensity bout of exercise is experienced.

Ed Burke PhD strongly advocates the use of Ribose in his most recent book ‘Serious Cycling’ available through www. amazon.co.uk

What is ribose and what does it do?

Ribose is a simple sugar, the carbohydrate backbone of ribonucleic acid (RNA) and deoxyribonucleic acid (DNA), so is a component of the genetic materials used to pass on genetic code from one generation to the next. As well as having this very important function, ribose is also the starting point for the production of ATP. Although cells cannot draw nucleotides back into them to re-form ATP, they can make it from scratch using ribose.

Ribose is found naturally in every living cell of the body and is synthesised from glucose, but this is slow, complicated and requires energy. Supplemental ribose is able to bypass this process, quickly re-building cellular ATP and returning muscle energy levels to normal. Again, research has shown that ribose supplementation increases the manufacture of ATP in skeletal muscle by 340 to 430 percent. It has also demonstrated that ribose improves the cell’s ability to salvage and re-use ADP and AMP by as much as 700 percent (these are the nucleotides that are usually lost from the cell for good). These are not ‘slight’ benefits. They are highly significant and quite staggering.

Why supplement with ribose?

Whilst all living cells contain ribose, there is not enough in the food we eat to re-stock energy levels. Ribose in meat is predominantly lost through the cooking process and there are insufficient quantities of the nutrient in plant foodstuffs to have any effect. Add to this the fact that it can take many days for the body to synthesise its own ribose from glucose and the benefits of supplementing with this nutrient become clear. Supplemental ribose is very quickly absorbed into the bloodstream with much of this absorption occurring before it is even swallowed. Once in the muscle cell itself, ribose can be very quickly transformed into ATP.

Without ribose supplementation, research suggests that most people’s muscles will take between 26 and 93 hours (1-4 days) to return cellular ATP levels to normal after strenuous exercise. It goes without saying that this could be longer or shorter depending on how strenuous and prolonged the exercise was (this is based on a 28 percent loss of nucleotides from the muscle). With ribose supplementation, a return to full cellular energy charge would take 6 to 22 hours (within a day).

How much ribose should I take?

You’ll get full usage instructions with your tub of TORQ ribose, but we’re not talking huge quantities here. To keep cellular ATP levels at their highest, you should be taking 3 to 5 grams (1 level teaspoon) of ribose per day. During periods of low load training or prolonged recovery, it’s questionable as to whether you’ll derive any benefit from taking ribose. Therefore a 500gram tub of TORQ ribose will keep you going for about 5 ½ months (3grams per day).

Is ribose supplementation safe?

Ribose is naturally occurring in every living cell of every living creature (animal or plant) on the planet. Ribose is not a compound that’s alien to the body, but one that it recognizes and uses effectively. It is because there are no substantial dietary sources of ribose that the body needs to make its own. This is why ribose supplementation is so astonishingly effective. It’s only in the last couple of years that scientists have worked out a way to manufacture this simple sugar relatively inexpensively. There have been incidences of diarrhea in individuals who have taken exceptionally high doses (60grams per day), but this is 12 to 20 times the suggested dose.

* For further information on the conclusive research into ribose supplementation read “D-RIBOSE, what you need to know” by Edmund R. Burke, Ph.D. Avery Publishing Group (1999). Also, in Edmund Burke’s latest book “Serious Cycling” published by Human Kinetics (2002) he dedicates a couple of pages to the positive and significant properties of ribose (pp 167-169). These books are both available for order through www.amazon.co.uk.

Click here to find out more about TORQ ribose

TORQ bar also contains TORQ ribose, so click here for further information.

All TORQ products can be ordered online via our secure server here at www.torqfitness.co.uk or by calling the local-rate TORQ order hotline: 0845 125 9081 (all major credit/debit cards accepted)

© Matt Hart. TORQ 2003


Picture below: D-RIBOSE – What you need to know

Five things you should know about ribose

Autumn is a busy time here at Bioenergy Life Science. We are gearing up for some major industry events, preparing to announce something new for anyone interested in how ribose can help with energy maintenance and muscle recovery, and our Team Ribose athletes are stepping up their training in anticipation of the Olympics and other world games.

Now is a good time to reflect on five things we’d like you to know about ribose, whether you are a food and beverage formulator who is interested in including Bioenergy Ribose in your products, an athlete looking to add ribose to your training arsenal, or simply someone who wants to understand how ribose might be able to satisfy your energy needs.

1. Ribose is natural. Every cell in our body makes ribose. Ribose is the rate-limiting compound in the production of energy compounds called Adenosine Triphosphate (ATP), which are like fuel for our cells. ATP provides us with the energy to run our bodies. It releases energy much like burning wood releases heat (energy) as its carbon bonds break. Our bodies are great at recycling. Each ATP molecule in our bodies gets used up and regenerated about 10,000 times a day.

2. Supplementing with ribose may help you reach your fitness goals. If your body is rapidly using your stores of ATP (for instance when you go for a jog or shovel snow) and it doesn’t have enough ribose on hand to replenish its energy compounds, then it’s got to make them another way. That alternative process can be slow, and it may even result in an unhealthy accumulation of toxic molecules.

Meanwhile, as you wait for your body to create more ATP, you will still be in a recovery mode. That’s why you may still feel sluggish, stiff or sore even after you’ve rested for a while. Some cells make ribose quickly. Others – including cells in your heart and muscles – make it very slowly because they are designed to preserve glucose. But when you supplement with ribose, your body will be able to quickly rebuild the depleted ATP and you’ll recover from exercise much faster. You also won’t fatigue as quickly, so you may be able to train longer and harder.

3. Bioenergy Ribose is the only ribose that is affirmed Generally Recognized as Safe (GRAS) by the Food & Drug Administration (FDA). By using Bioenergy Ribose, you will have the benefit of using the world’s premier distributor of D-Ribose while also ensuring that it is not considered “adulterated” for failure to comply with the U.S. FDA.

4. Bioenergy Ribose is patented. Any product containing ribose and designed for increasing or replenishing energy, alleviating soreness or cramping, building lean muscle mass, improving athletic performance or any other application covered by our patent portfolio, must contain only Bioenergy Ribose.

5. Ribose helps lower the glycemic load. Sure it tastes sweet, but it won’t cause blood sugar spikes.

Stay tuned for exciting breaking news. And share your Bioenergy Ribose stories. Like us on Facebook and follow us on Twitter!


Heart Health | Using D-Ribose for heart health

D-Ribose is a simple sugar with a lot of power. It is one of the building blocks of RNA (genetic material) and also the basis for production of adenosine triphosphate, otherwise known as ATP. ATP is the compound we use to supply energy to our skeletal muscle and heart. Every cell in the body uses ATP for processes such as respiration, digestion and tissue regeneration. Our body makes its own D-Ribose from food but this is a slow process, and the levels deplete in those who exercise at extreme levels or worse, those suffering from cardiovascular issues.

In fact, D Ribose is cited in research as an essential nutrient for protection and recovery in cardiovascular disease. A study in The European Journal of Heart Failure shows that ribose appears to improve heart function and quality of life among patients by increasing levels and availability of ATP.

In a study cited below, 16 class III-IV, heart failure patients were supplemented with 15 grams of D-Ribose daily for eight weeks. The results were that D-Ribose supplementation improved the ventilation efficiency in advanced heart failure patients by 16% and Vo2 by 19%.

There is a short amount of time in which you can help repair your body following a heart attack. Ischemia (restricted flow of oxygen/blood) can cause massive depletion of ATP in the heart muscle. Depletion in ATP can result in the reduction in diastolic function meaning that the heart takes in less blood when it relaxes.

D-Ribose helps myocardial cells, restoring ATP, increasing contractions and increasing the amount of blood flow into the heart, thus preventing “reperfusion injury” and free-radical damage to the tissue.

Prevention each day would be better, but with sugar?

Although ribose is called sugar, ribose is metabolised in an entirely different way to regular blood raising sugars, such as glucose, fructose, and sucrose. Our bodies use sugars to fuel ATP turnover, but while other sugars increase blood glucose levels, and create spikes in insulin secretion and weight gain, ribose does not. On its own, ribose causes a minor decrease in blood sugar levels. When taken with other carbohydrates ribose can help modulate blood sugar spiking.

When should you consider D-Ribose supplements?

  • If you want to protect against age-related issues, such as deterioration of mitochondria and degenerative heart conditions.
  • If you take statin drugs, D-Ribose can help with associated myalgia.
  • If you suffer from high blood pressure.
  • If you use positive inotrope drugs (drugs that increase heart function such as Digoxin)
  • If you suffer from arrhythmia
  • If you suffer from angina
  • If you suffer from peripheral vascular disease
  • If you are recovering from cardiac surgery
  • If you want to protect your muscles from high-intensity exercise or strenuous activity

How do I take D-Ribose Supplements?

First of all, it is essential to choose a 100% pure, no compromises in production, a high quality product such as Sweet Cures High Energy D-Ribose™ . Next, it is important to take a clinically effective dosage (you may wish to discuss this with your healthcare team who know your situation best). 5 grams equates to a teaspoon of D-Ribose sugar. It can be mixed with water or used in the place of sugar for instance on breakfast cereal. The following broad guidelines that are considered effective will help you choose a dosage:

  • 5 grams a day for protecting your heart and muscle health and avoiding muscle pain after strenuous exercise
  • 10-15 grams a day if you suffer from mild-moderate heart failure or peripheral vascular disease
  • 10-15 grams a day for athletes performing intense training or events
  • 10-15 grams a day if you are recovering from a heart attack/heart surgery/ or suffer from stable angina
  • 15-30 grams a day if you suffer from frequent angina/dilated cardiomyopathy/advanced heart failure or are awaiting heart transplant surgery ( THIS MUST BE UNDER MEDICAL SUPERVISION).

Seeking Medical Support

It would be helpful to work with a doctor who knows you well and has researched D Ribose and its amazing benefits. However, if you are pregnant or breastfeeding or suffer from diabetes, you MUST seek support from your healthcare provider before taking a D Ribose supplement.


Int J Cardiol.2009 Sep 11; 137(1):79-80. doi: 10.1016/j.ijcard.2008.05.025. Epub 2008 Jul 31.

3 Health Benefits of D-Ribose + Side Effects

D-ribose is a sugar involved in producing energy in the body and is also the structural basis of DNA and RNA. As a supplement, it is commonly used to help with heart disease and chronic fatigue syndrome. Read on to see how this sugar may be an effective treatment for these conditions and others.

What Is D-Ribose?

D-ribose is a naturally occurring sugar present in all living cells. It is a key component in many biological pathways but is most active in glycation (bonding between a sugar and a protein or fat molecule) [1].

D-ribose, together with adenine, makes the adenosine molecule of adenosine triphosphate (ATP), the main storage and transportation unit of energy [2].

D-ribose is also used to make nicotinamide adenine dinucleotide (NAD) and flavin adenine dinucleotide (FAD), two important molecules involved in cellular respiration.

D-ribose is also the key structural basis of RNA and DNA [3, 4, 5].

Health Benefits of D-Ribose Supplementation

There are many commercial D-ribose supplements, especially to increase athletic performance. However, the FDA hasn’t approved them for any conditions due to the lack of solid clinical research. Regulations set manufacturing standards for supplements but don’t guarantee that they’re safe or effective. Speak with your doctor before supplementing with D-ribose.

Insufficient Evidence for:

1) Athletic Performance

D-ribose may enhance the recovery of energy reserves following inadequate blood supply to organs and tissues after high-intensity exercise [6].

In a study of 24 bodybuilders 10 grams/day of D-ribose for 4 weeks significantly increased bench press strength [7].

In another trial on 26 healthy people, the same amount of D-ribose improved power output while reducing perceived exertion and creatine kinase level (which are normally high after strenuous exercise) [8].

A multi-herbal supplement with D-ribose failed to improve performance in a small trial on 17 cyclists, but it supplied a much lower dose (2.4 – 4.8 grams/day of a blend also containing other ingredients) [9].

Despite its widespread use to increase athletic performance, only 2 small clinical trials back it up. The evidence to support this use is insufficient until larger, more robust clinical trials are conducted.

2) Heart Disease

Several studies found that D-ribose increases ATP levels in heart cells and improves heart function [10, 11, 12].

Congestive heart failure is a condition in which heart muscles don’t pump blood as well as they should. In a clinical trial of 15 congestive heart failure patients, D-ribose improved heart function [13].

D-ribose helped 20 men with stable heart disease to exercise longer without developing chest pains (angina) or ECG changes in another trial [14].

In mice, D-ribose and L-cysteine supplementation lowered blood LDL and other oxidized fat. It also reduced oxidative stress in the aorta, the main artery that carries blood from the heart [15].

However, D-ribose showed no benefits in treating chronic heart failure in healthy mice or in mice with elevated myocardial creatine [16].

The results are promising, but the evidence is insufficient to claim that D-ribose helps with heart disease. Further clinical research is needed.

3) Fibromyalgia and Chronic Fatigue Syndrome

A pilot study of 41 patients with fibromyalgia or chronic fatigue syndrome found that 5 grams of D-ribose daily improved energy, sleep, mental clarity, pain intensity, and well-being [17].

A case study found that 5 grams of D-ribose taken twice daily with other medications reduced fibromyalgia symptoms, which returned after one week of stopping D-ribose supplementation [18].

A single clinical trial and a case study are clearly insufficient evidence to support the benefits of D-ribose in people with fibromyalgia and chronic fatigue syndrome. More clinical trials on larger populations are required.

Case Studies (Very Low to Lacking Evidence)

A few case studies document improvement of the following conditions with D-ribose supplementation:

  • Restless leg syndrome [19]
  • A rare genetic disorder with severe dexterity and motor retardation (adenylosuccinase deficiency) [20, 21]
  • Another genetic disorder in which the muscles cannot process the energy molecule ATP (myoadenylate deaminase deficiency) [22, 23]

Case studies can only be considered anecdotes with a much lower level of evidence than any clinical studies. Additionally, two of these conditions failed to respond to D-ribose therapy in some cases [24, 25].

Animal Studies (Lack of Evidence)

No clinical evidence supports the use of D-ribose for any of the conditions listed in this section. Below is a summary of the existing animal and cell-based research, which should guide further investigational efforts. However, the studies listed should not be interpreted as supportive of any health benefit.

Kidney Protection

D-ribose reduced kidney dysfunction and tissue damage caused by the chemotherapy drug Cisplatin in mice [26].

D-ribose also reduced kidney damage caused by lack of blood supply and decreased neutrophil activation in rats [27].

Brain Protection

D-ribose prevents the activation of pro-apoptotic (programmed cell death) genes in the hippocampus, demonstrating a neuroprotective effect in mice with irregular heartbeat [28].

Weight Loss

D-ribose increased gut motility in mice and increased energy expenditure, which decreases body weight [29].

Testicular Toxicity Caused by Aluminum

D-ribose (in combination with L-cysteine) reduced aluminum-induced testicular toxicity in rats [30].

User Experiences

The opinions expressed in this section are solely those of D-ribose users, who may or may not have medical or scientific training. Their reviews do not represent the opinions of SelfHacked. SelfHacked does not endorse any specific product, service, or treatment.

Do not consider user experiences as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare providers because of something you have read on SelfHacked. We understand that reading individual, real-life experiences can be a helpful resource, but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider.

Most users reported taking D-ribose supplements for increasing their energy levels and athletic performance. A few took it to improve heart palpitations and muscle pain. Many of the users were happy with the results and reported less fatigue.

Dissatisfied users mainly reported that the supplement was less effective than they had expected or didn’t work at all. Others complained about its high price. A diabetic user reported experiencing adverse effects similar to those of sugar spikes and suspected these were due to D-ribose being obtained from corn sugar.

D-Ribose Dosage, Side Effects, Supplements


Because D-ribose supplements are not approved by the FDA for any conditions, there is no official dose. Users and supplement manufacturers have established unofficial doses based on trial and error.

Clinical studies have used between 5 – 15 g daily. When supplementing with 15 g it is advised to separate into three 5 g doses.

Side Effects

Keep in mind that the safety profile of D-ribose is relatively unknown given the lack of well-designed clinical studies. The list of side effects below is not a definite one, and you should consult your doctor about other potential side effects based on your health condition and possible drug or supplement interactions. Seek medical attention if you notice any severe or mild, persistent adverse effects after supplementing with D-ribose.

By inducing protein aggregation and rapidly producing AGEs (advanced glycation end products), D-ribose may be involved in cell dysfunction and cognitive impairments [31, 32].

Long-term oral administration of D-Ribose induced memory loss with anxiety-like behavior and also elevated Aβ-like deposition and Tau hyperphosphorylation associated with Alzheimer’s in mice [33].

Ingredient Spotlight: Ribose

Chemically known as D-ribose, ribose is a 5-carbon sugar (pentose) that is found in every cell in the body. Due to its chemical structure, it is not used by the body as a typical sugar, such as glucose (6-carbons)-meaning it is not metabolized via glycolysis, the biochemical pathway in which sugar is converted into energy. Ribose serves as the carbohydrate backbone of ribonucleic acid/RNA (as ribose) and of deoxyribonucleic acid/DNA (as deoxyribose), both of which are involved in cell growth and function.

In addition to its role in genetics, ribose is a major component of the energy molecule known as ATP (adenosine triphosphate). ATP consists of a base, known as a purine; three phosphate (triphosphate) molecules; and the sugar ribose. Ribose is the only sugar used by the body to help regulate the metabolism of nucleotides-i.e., ATP, ADP (adenosine diphosphate), and AMP (adenosine monophosphate).

Ribose is the main molecule in energy recovery, helping to support the synthesis of energy compounds needed by the body for various metabolic processes. During times of metabolic stress or disease, ribose can help restore normal, healthy levels of ATP required for the intricate biochemical and physiological processes that help maintain life.

Cellular and Cardiovascular Function

The heart is a metabolic machine. On average, it beats approximately 100,000 times per day. This degree of metabolic activity requires a significant energy reserve and the constant recycling and/or production of energy molecules.

Cardiovascular disease (CVD) continues to be a leading cause of death worldwide. One of the common factors in CVD is a lack of oxygen (ischemia), which leads to a significant decrease in ATP production and overall heart function. Joanne Ingwall, PhD, of Brigham and Women’s Hospital proposed that a failing heart is energy starved.(1) Ribose helps improve the synthesis of adenine nucleotide reserves, which in turn helps increase ATP production and improves the heart’s tolerance to ischemia.(2)

How does ribose accomplish this? ATP recovery depends on increased levels of phosphoribosyl-pyrophosphate (PRPP), which is formed from ribose-5-phosphate by the enzyme ribosephosphate diphosphokinase. Increased levels of PRPP can aid in the production of ATP.

In addition to its major role in ATP synthesis, PRPP is the gatekeeper for maintaining purines inside the cells, helping to ensure a pool of these ATP precursors to support energy recovery. During transient myocardial ischemia, levels of ADP and AMP increase, while their rephosphorylation to ATP decreases significantly. After long periods of ischemia, AMP and ADP are broken down to adenosine, inosine, and other metabolites, which are then cleared from the cell. The loss of purines causes significant metabolic disturbances. If the cells lose purines such as adenine, they cannot resynthesize much-needed ATP. During times of extreme stress-such as heart attack or congestive heart failure (CHF)-purines are lost from heart cells, thereby limiting the heart’s ability to generate the ATP needed to regain normal heart function. Ribose quickly forms PRPP, which helps prevent the loss of purines and serves as the driver of ATP synthesis.

Studies show that providing daily ribose supplementation helps improve diastolic function, quality of life, and physical function scores in patients with CHF.(3) Ventilatory efficiency is recognized as an important predictor of survival and disease progression among patients with CHF. Ribose has been shown to improve ventilatory efficiency, and demonstrates a subjective improvement in quality of life in CHF patients. Patients given ribose were able to breathe more easily and with greater efficiency (noted by improved oxygen uptake).(4,5)

There are no good natural sources of ribose. The body, although capable of making ribose from glucose, does so very slowly and not efficiently enough to support an ailing cardiovascular system. In many cardiovascular conditions, including ischemia, CHF, and cardiomyopathy, supplemental ribose provides a significant benefit by increasing the speed of ATP repletion and enhancing functional recovery after injury in acute and chronic cardiovascular disease.(6)

Energy Metabolism, Exercise Performance

In addition to its numerous benefits in cardiovascular health, ribose has been shown to support many other biochemical and physiological functions in the body. Jacob Teitelbaum, MD, and John St. Cyr, MD, PhD, noted experts on chronic fatigue syndrome (CFS) and D-ribose, respectively, conducted a pilot study in 41 patients diagnosed with CFS and/or fibromyalgia. Both conditions are associated with impaired cellular energy metabolism. With ribose supplementation, a significant improvement was seen in the five major areas of assessment: energy, sleep, mental clarity, pain intensity, and well being in patients receiving ribose.(7)

Ribose supplementation has also been shown to support exercise performance and recovery. One study investigated the effect of ribose on skeletal muscle total adenine nucleotide (TAN) concentration following high-intensity exercise (cycle sprints). Following the exercise period, muscle biopsies revealed a significantly greater TAN in the ribose-supplemented group.(8) This suggests ribose may provide an ergogenic effect over time in high-intensity cycling activity.

In a four-week study in recreational male body builders, ribose supplementation was shown to support an increase in strength and muscle endurance, but had no affect on body composition.(9) Supplementation of ribose demonstrates a significant benefit to cellular energy metabolism by limiting the depletion of TANs and supporting ATP resynthesis in muscle tissue, thereby helping to modulate key mechanisms involved in exercise performance.

In another study, one week of intense intermittent cycling was sufficient enough to markedly reduce muscle adenine nucleotide levels. Following this intense training, ribose supplementation significantly enhanced the rate of adenine nucleotide resynthesis, most likely by increasing PRPP synthesis. PRPP synthesis is an essential rate limiting factor for ATP resynthesis in skeletal muscle, and may in fact influence exercise performance.(10)

The Future of Ribose

Ribose is the fundamental building block of ATP and the only compound capable of regulating the amount of energy in the cell. Without ATP, cellular function is lost. Ribose is an inexpensive, safe, and efficacious tool, helping improve diastolic heart function and quality of life in patients with coronary artery disease, congestive heart failure, and cardiomyopathy.

As cardiovascular disease continues to be the leading cause of death worldwide, more healthcare practitioners need to be made aware of, and educated about, the potential benefits of ribose. There is significant clinical evidence, much of it based on randomized controlled studies, for the efficacy and safety of ribose in cellular energy metabolism related to cardiovascular health, exercise performance, chronic fatigue, and a host of other common conditions. Mainstream medicine needs to take a closer look at the wide-reaching clinical effects of ribose and allow more people to reap the benefits of this truly versatile compound. 



  1. Ingwall J.  On the hypothesis that the failing heart is energy starved: Lessons learned from the metabolism of ATP and creatine.  Current Hypertension Reports  2006;8:457-464.
  2. Erdman E, et al.  Effects of ribose on exercise-induced ischemia in stable coronary artery disease.  Lancet  1992;340:507-510.         
  3. Omran H, et al.  D-ribose improves diastolic function and quality of life in congestive heart failure patients: A prospective feasibility study. Eur J Heart Fail  2003;5:61 
  4. Vijay N, et al.  D-ribose benefits heart failure patients.  J Med Food  2008;11:199-200.
  5. Carter O, et al.  D-ribose supplementation improves peak exercise capacity and ventilatory  efficiency  in heart failure patients. JACC2005;45 Suppl A:185A.
  6. Pauly D, Pepine C.  D-Ribose as a supplement for cardiac energy metabolism.  J Cardiovasc Pharmacol Therapeut  2000;5:249-258.
  7. St. Cyr J, et al.  The use of D-ribose in chronic fatigue syndrome and fibromyalgia: A pilot study.  J Altern Complement Med
  8. Gallagher P, et al.  Effects of ribose supplementation on adenine nucleotide concentration in skeletal muscle following high intensity exercise.Medicine and Science in Sports and Exercise  2001;33, S167.  
  9. Antonio J, et al.  The effects of four weeks of ribose supplementation on body composition and exercise performance in healthy, young, male recreational bodybuilders: a double-blind, placebo-controlled trial.   Curr Ther Res  2002;63:486-495.
  10. Hellsten Y, et al.  Effect of ribose supplementation on resynthesis of adenine nucleotides after intense intermittent training in humans.  Am J Physiol Regul Integr Comp Physiol   2004;286:R182-R188.

90,000 D-ribose

D-ribose is a common sugar that our bodies synthesize every day. To break it down, you need ATP (adenosine triphosphate) – the main carrier of energy, “living” in every cell. Without this substance, some reactions are impossible, during which important cellular compounds are formed. It is for this reason that the amount of ribose affects the rate at which those same compounds are synthesized.

What is D-ribose?

It is a simple monosaccharide with five carbon atoms. He takes part in energy metabolism, as well as in the construction of DNA and RNA, some vitamins. The main function of D-ribose is related to metabolism: the saccharide helps the body restore energy reserves and, in particular, the concentration of ATP. The more it is, the more often the heart muscle contracts, the higher the overall tone and the more physical activity our body can withstand.

D-ribose is responsible for the regulation of metabolic processes, and no other substance can replace it.It normalizes the synthesis of pyrimidines and purines – components on which the rate of consumption of energy reserves depends. If there are few of them, then proteins in the body will not be produced, and cells will lose the ability to divide, grow and develop.

Ribose belongs to the group of monosaccharides, but it does not increase blood sugar levels. Because of this, it can be used in the preparation of various dietary meals and drinks: the substance has a slightly sweetish taste and dissolves well in cold or hot liquid.

Who needs to take D-ribose

Supplements containing ribose will benefit anyone with an active lifestyle and regular gym use. It will also not harm people suffering from chronic fatigue and frequent stress, as well as those who have problems with the work of the cardiovascular system.

What foods contain ribose?

Monosaccharide is present in almost all products of plant and animal origin.Most of it is found in beef, chicken and turkey, eggs, milk, cheese, mushrooms, as well as sardines, anchovies and herring.

What is the use of D-ribose?

The beneficial properties of ribose are manifested in all cases, regardless of how it is used: to recover from intense training, relieve muscle tension or increase physical performance.

Provides energy
During the training, the ATP reserves are released, and at this time our monosaccharide is “turned on”, which replenishes the losses.As a result, the flow of energy to the muscles is accelerated, and after exercise, fatigue goes away rather quickly. Some studies say that athletes who took ribose over the course of one month did more reps and used heavier weights compared to those who did not use the supplement.

Strengthens the heart muscle
It’s the same here: ribose increases the concentration of ATP in the heart cells, due to which the organ receives the energy it needs to pump blood. Many health professionals report that D-ribose medications help patients with heart failure breathe better and easier. In addition, the monosaccharide helps to reduce the concentration of “bad” cholesterol and oxidized fat, which accumulate in the arteries and prevent blood flow to the heart.

Protects the brain
In the hippocamus, special pro-apoptotic genes are formed, which are initially programmed for cell death. Ribose blocks their activity, that is, it has a neuroprotective effect.

Helps with diabetes
What causes diabetes? This disease is due to the fact that the body produces an insufficient amount of insulin, which is why the blood sugar level rises. The action of ribose is aimed at increasing the rate of insulin release, due to which the “sugar background” is normalized. The monosaccharide, which tastes sweet, can be a great alternative to regular sugar.

Side effects

With an incorrect dosage of D-ribose (more than 10 g on an empty stomach), temporary hypoglycemia occurs.This condition is associated with a drop in blood sugar. To avoid such a reaction, you must additionally consume other carbohydrates. This is especially important for people taking insulin for diabetes. Another possible side effect is indigestion, which manifests itself as mild diarrhea. It is also associated with increased dosage of the monosaccharide.

In some cases, ribose can cause allergic reactions and breathing difficulties, which is usually associated with individual intolerance and increased dosage.That is why, before taking a supplement, you should definitely consult with your doctor to avoid unpleasant consequences.

Admission rules

It is recommended to consume no more than 10 g of ribose per day. With regular training, the dietary supplement is taken 2.5 g half an hour before and immediately after sports.

D-ribose is a sugar found in all living organisms. He takes an active part in the production of energy and the construction of genetic material.Regular intake of dietary supplements containing ribose can improve athletic performance, endurance and strength. In addition, the monosaccharide has a positive effect on the work of the cardiovascular muscle, helps to fight the manifestations of chronic fatigue and to endure stressful situations more easily.

90,000 D-Ribose: Supplement for Heart and Muscles | Supplements: Scientific Facts Only

D-ribose supplements are recommended to improve cardiovascular health and to relieve chronic fatigue syndrome and fibromyalgia.

They are also found in many post-workout mixtures for athletes as they aid in muscle recovery after exercise.

Benefits of Supplement

D-ribose is a sugar-like molecule that our bodies use to create adenosine triphosphate (ATP), an energy-carrying molecule used in many metabolic processes. When cells need energy, D-ribose is converted from stored cells to ATP. ATP, in turn, delivers energy to the place in the cell where energy-intensive activity takes place.

Useful for people with ischemic cardiovascular diseases

Myocardial ischemia is a common cardiovascular disease. This is a condition in which blood flow to the heart is reduced, which prevents it from getting enough oxygen.

Complications of this condition include heart attack, heart rhythm disturbances and heart failure.

Myocardial ischemia is known for decreasing the energy level in cells, which affects their integrity and ability to function normally.Scientists report that heart failure occurs when the heart is hungry for energy and tries to find a way to make up for the lack of energy in the cells.

According to an article published in the journal Recent Patents on Cardiovascular Drug Discovery, scientists have found compelling evidence that D-ribose has the ability to significantly replenish energy levels in cells after myocardial ischemia. Clinical trials have also shown that such supplements are beneficial for patients with congestive heart failure.

Improves Quality of Life in Patients with Congestive Heart Failure

In a study published in the European Journal of Heart Failure, researchers examined the effects of oral D-ribose supplementation on 15 patients with chronic coronary insufficiency and congestive heart failure …

As a result, there was an improvement in diastolic functional parameters and an increase in the quality of life of the subjects.At the same time, study participants who received a placebo did not notice significant changes or improvements in their quality of life.

A clinical review published in the journal Experimental & Clinical Cardiology summarized the results of other clinical studies that found similar benefits to supplementation with D-ribose.

In one study, daily D-ribose supplementation allowed patients with persistent severe coronary insufficiency to exercise longer with fewer symptoms or possible electrocardiographic changes.

Results from a 2001 study demonstrated a significant benefit of daily D-ribose supplementation in patients with stages 2 and 3 congestive heart failure. In particular, supplementation resulted in improved diastolic compliance with comparable measurements related to left atrial function. In addition, there was a significant improvement in the quality of life and physical activity of patients.

Helps reduce symptoms of chronic fatigue syndrome and fibromyalgia

Firomyalgia and chronic fatigue syndrome are debilitating conditions believed to be associated with impaired cellular energy metabolism.

Firomyalgia and chronic fatigue syndrome share some of the same symptoms: fatigue, loss of memory or concentration, unexplained joint and muscle pain, and restless sleep.

In 2006, a pilot study was conducted to determine if supplementation with D-ribose could alleviate the symptoms of these conditions. Forty-one patients received the supplement three times a day. Scientists assessed the following five indicators: energy, sleep, clarity of consciousness, pain intensity and well-being.

D-ribose supplementation resulted in significant improvement in approximately 66% of the subjects: energy levels increased by 45% on average, and overall well-being improved by 30%.

Despite encouraging results, this study did not include a placebo group or long-term follow-up. More in-depth research on this issue is still required.

Another study involved a 37-year-old woman with symptoms of severe musculoskeletal pain and stiffness, foggy consciousness, bouts of diarrhea, and sleep disturbances.She was diagnosed with fibromyalgia. Standard drug treatment has had limited benefits and caused adverse side effects.

In addition to the existing treatment, she started taking D-ribose twice a day. After 14 days, the woman noticed a decrease in her existing symptoms. She also noted the absence of side effects. After a month of taking D-ribose, her condition was close to normal.

After stopping the supplement, the patient began to experience fibromyalgia-related symptoms within seven days.After resuming the supplementation, symptoms improved significantly within 14 days.

Restores the concentration of ATP in the muscles after intense training

During intense physical activity, the level of ATP in skeletal muscle is seriously depleted. Recovery may take several days, during which the burning sensation and muscle fatigue will persist.

In a study published in 2004, seven healthy men did vigorous cycling twice a day for a week.As expected, immediately after the last workout, the ATP level in the muscles was quite low.

After training, the subjects received either ribose or placebo three times a day for three days. After 72 hours, the muscle ATP concentration in the ribose supplemented subjects returned to normal, while the ATP level in the placebo group was still low.

Side Effects

It seems that short-term oral or intravenous administration of D-ribose is safe for the body.The results of many short-term clinical studies have shown good tolerability.

Side effects such as diarrhea, abdominal discomfort, nausea and headache have been reported.

It was also found that taking this supplement leads to a sharp decrease in blood sugar levels. For this reason, D-ribose interacts with diabetes medications.

Studies of the side effects associated with long-term use have not yet been conducted.


D-ribose is a sugar-like molecule that our bodies use to create adenosine triphosphate (ATP). Every cell needs a sufficient level of ATP to function properly.

Scientists believe that firomyalgia and chronic fatigue syndrome are associated with impaired cellular energy metabolism, in which the heart experiences an energy hunger.

When looking for therapies to restore energy levels in cells, researchers focused on D-ribose supplementation.

This supplement has been shown to improve the quality of life of patients with congestive heart failure.

In patients with fibromyalgia and chronic fatigue syndrome, D-ribose significantly increases energy levels and results in overall symptom relief and improved well-being.

This sugar-like molecule also has the ability to increase the rate of recovery of ATP levels in muscles after intense exercise.

Combined with modern pharmaceuticals, D-ribose supplementation may help to better treat patients with these conditions.

Source : https://russiaherb.com/ribose/

Important: before using any dietary supplements, consult your doctor. Remember, supplements are not a substitute for drugs and traditional medicine. The dosage of dietary supplements, like medicines, should be established by the attending physician according to the patient’s condition.


Other names

Beta-D-ribofuranose, D-ribosa, D-ribose, Ribosa.


Ribose is used to improve athletic performance and the ability to increase muscle energy.It has also been used to improve symptoms of chronic fatigue syndrome (CFS), fibromyalgia, and coronary artery disease. Ribose has been used to prevent symptoms such as cramping, pain, and stiffness after exercise in people with an inherited disorder called myoadenylate deaminase deficiency (MAD) or AMP disinfection deficiency (AMPD deficiency). Ribose has also been used to improve physical performance in people with another inherited disorder called McArdle disease.

Health care providers sometimes administer intravenous (IV) ribose as part of an imaging procedure used to measure the extent of damage to the heart muscle in people with coronary artery disease. Ribose has also been used intravenously in MAD patients to prevent symptoms such as cramping, pain, and stiffness.

Functional principle

Ribose is a source of energy that the body makes from food. There is some evidence that supplemental ribose may prevent muscle fatigue in people with genetic disorders that prevent the body from producing sufficient energy.It can provide extra energy to the heart during exercise in people with heart disease.


Clogged heart arteries (coronary artery disease). Taking ribose is effective in improving the ability of the heart in people with coronary artery disease.
Myoadenylate deaminase deficiency (MAD). Taking ribose is effective for preventing symptoms such as cramps, pain, and stiffness after exercise in people with MAD, also known as disinfectant AMP deficiency (AMPD deficiency).
Athletic lessons.

Chronic Fatigue Syndrome (CFS). Early research suggests that taking a ribose supplement can improve energy, sleep, and feelings of well-being in people with chronic fatigue syndrome.
Congestive heart failure. Early research suggests that people with congestive heart failure who take ribose for 3 weeks have better heart function and an improved quality of life.
Coronary artery bypass grafting (CABG) operation.Early research suggests that people who take a ribose supplement just before surgery have better heart function after surgery.
Fibromyalgia. Early research suggests that taking a specific ribose supplement can improve energy, sleep, and feelings of well-being, and reduce pain in people with fibromyalgia.


Ribose is safe for most people when taken orally for short-term use or given intravenously (IV) by a healthcare provider.Ribose can cause several side effects, including diarrhea, stomach discomfort, nausea, headache, and low blood sugar.

Ribose Powder | Body & Fit

Ribose Powder | Body & Fit


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  • 100% d-ribose powder
  • Building material for ATF
  • Odorless, versatile to use according to your calorie and nutritional requirements.

Support your workout with D-ribose powder, a type of simple carbohydrate that is produced by our body. D-ribose powder is a component of adenosine triphosphate (ATP) that energizes our cells, is odorless and popular for strength and high-intensity workouts. It is a common ingredient in pre-workout drinks. Combine it with your favorite ingredients to create your own pre-workout formula. Take 30-60 Minutes Before Workout To Reach Your Fitness Goals!

  • 100% d-ribose powder
  • Building material for ATF
  • Odorless, versatile to use according to your calorie and nutrient requirements.
  • Available in 200 g packaging

Mix one scoop (5 g) with 200 ml water or add to your own pre-workout formula.

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90,000 D-ribose in Solstic Revive

We disassemble the ingredients of dietary supplements NSP

What is it

D-ribose is a monosaccharide, which is a simple sugar. It is the basis of RNA and DNA nucleic acids, which means it is present in every cell of a living organism.

Ribose is needed for energy

Our body needs energy to transport molecules across membranes, muscle contraction, enzyme formation and other biochemical processes.ATP, adenosine triphosphoric acid, is its universal source.

Chemically, ATP is a free nucleotide derived from adenine and ribose.

With insufficient blood flow to the tissues, stress, vasospasm or during exercise, the body does not reproduce ATP quickly enough. A deficiency can negatively affect muscle function and endurance.

Taking ribose and exercise

Taking ribose before, during and after vigorous exercise provides muscle energy and improves endurance.

In an experiment on laboratory rats, taking a supplement with ribose increased the rate of nucleotide (ATP) synthesis in working and non-working muscles 3-4 times. Another animal study found ribose’s ability to restore nucleotides to normal levels over 12 to 24 hours of intense exercise.

Medical research indicates that taking a ribose supplement can increase the availability of ATP in patients with medical conditions and protect against ischemia.

Ribose is able to produce additional energy (blood glucose) by supplying it to working muscles.

In the experiment, 6 participants took between 2 and 10 grams of ribose. As a result, blood glucose levels were maintained for more than two hours compared to the placebo control group.

Short-term ribose supplementation may improve performance during anaerobic exercise.

This is evidenced by the results of a study with testing athletes. Participants in the experiment worked on a stationary bike, performing a series of six sprint runs for 10 seconds with breaks of 1 minute. In four of the six races, the maximum performance indicators increased from 2.2 to 7%, and the overall performance increased by 2-10%.

Ribose does not improve performance in strength sports – there is no scientific evidence to support this effect.

Bring Solstic Revive with you

Go to the gym or for a run to restore muscle energy after exercise.

On a hike and on foot – refresh yourself when you are tired and need to recuperate.

About dosage

The minimum daily requirement for ribose is 2.2 g.The recommended intake is 3 – 5 g per day. With increased load – 5 – 10 g per day.

In 1 sachet “Solstic Revive” 500 mg of ribose. The product also contains vitamins of group B, C, E, glucosamine, inulin dietary fiber, calcium, magnesium, sea salt, pomegranate juice, grape skin extract and amino acids: L-carnitine, taurine, glycine.

Interesting fact about ribose
In 2019, researchers discovered ribose … in meteorite dust!
Amazingly, such a fragile molecule has survived in such an ancient material.
This is further evidence in favor of the theory that the “components” for life
meteorites were brought to Earth.

Sources of

  • http://sportwiki.to
  • S.A. Polievsky “Fundamentals of individual and collective nutrition of athletes” Publisher: Physical culture and sport, 2005
  • https: // www.webmd.com/vitamins/ai/ingredientmono-827/ribose
  • https://www.nasa.gov/press-release/goddard/2019/sugars-in-meteorites

Ribose – properties, preparation and application

Ribose is a monosaccharide from the pentose group, colorless crystals, easily soluble in water and having a sweet taste. Epimer of arabinose. Opened in 1905.

(2R, 3R, 4R) – 2,3,4,5- tetrahydroxypentanal (D- ribose)
(2S, 3S, 4S) – 2,3,4,5- Tetrahydroxypentanal (L-ribose)
Traditional names ribose, ribopentose
Raz.formula C 5 H 10 O 5
State colorless crystals
Molar mass 150.13 g / mol
Density 0.8 g / cm³
• melting 90 ° C
• in water readily soluble in water
Reg.CAS number 50-69-1
ChEBI 33942

L-ribose is a synthetic sugar isolated by Emil Fischer and Oscar Piloty in 1891.

In 1909, Phoebus Levene and Walter Abraham Jacobs discovered that D-ribose is a natural product, an enantiomer of L-ribose discovered by Fischer and Piloty, and a natural component of nucleic acids.

Fischer chose the name “ribose” as a partial permutation from the name of another saccharide, “arabinose”, to which ribose is an epimer of the 2 ′ carbon.

Chemical properties

Ribose, like other monosaccharides, exists in solutions in the form of an equilibrium mixture of acyclic and cyclic: pyranose and furanose forms (anomeric α- and β-ribopyranose and α- and β-ribofuranose). The ratio of these forms in solution: β-ribopyranose (59%), α-ribopyranose (20%), β-ribofuranose (13%), α-ribofuranose (7%), acyclic (0.1%).

Ribose is reduced with hydrogen or sodium amalgam to the corresponding aldite (ribitol) and oxidized at the aldehyde group to the corresponding aldonic (ribonic) acid, which can cyclize under the synthesis conditions to ribonolactone, forms ozazones with hydrazines.

Biological role

Ribose in the form of β-D-ribofuranose is a component of ribonucleic acid, nucleosides, nucleotides and other biological important substances.

Ribose is a component of RNA and is used in genetic transcription. The β-D-ribose derivative – β-D-deoxyribose is a component of DNA. Also β-D-ribose is a component of ATP and some other substances involved in metabolism.


Ribose, which is a part of biological structures, has the property of chiral purity: DNA and RNA molecules are built exclusively on the “right” ribose.

Ribose is … What is Ribose?

Acyclic form of D-ribose

Ribose is a monosaccharide from the pentose group, colorless crystals, easily soluble in water and having a sweet taste. Epimer arabinose Opened in 1905.

Chemical properties

Ribose, like other monosaccharides, exists in solutions as an equilibrium mixture of acyclic and cyclic furanose forms (anomeric α- and β-ribofuranoses).

Ribose is reduced by hydrogen or sodium amalgam to the corresponding alditol (ribitol) and oxidized at the aldehyde group to the corresponding aldonic (ribonic) acid, which can cyclize under the synthesis conditions to ribonolactone [1] , forms ozazones with hydrazines.

Biological role

Ribose is a part of ribonucleic acid, adenosine, nucleotides and other biological important substances.

Ribose is a component of RNA and is used in genetic transcription. A ribose derivative, deoxyribose, is a component of DNA. Also, ribose is a component of ATP and some other substances involved in metabolism.


  • Merck Index, 11th Edition, 8205


  1. John D.Williams et al. D-Ribonolactone and 2,3-isopropylidene (d-ribonolactone). Organic Syntheses, Vol. 82, p. 75 (2005).
General: Aldose Ketose Furanose Pyranose
Geometry Anomers Mutarotation Howors
Dioses Aldodiose (Glycolaldehyde)
Trioses Ketotriose (Dihydroxyacetone) Aldotriose (Glyceraldehyde)
Tetroses Ketotetrose (Erythrulose) Altotetroses (Erythrose, Treose)
Pentose Ketopentose (Ribulose, Xylulose)

Aldopentose ( Ribose , Arabinose, Xylose, Lixose)

Deoxysaccharides (Deoxyribose)

Hexose Ketohexose (Psycosis, Fructose, Sorbose, Tagatose)

Aldohexoses (Allose, Altrose, Glucose, Mannose, Gulose, Idoza, Galactose, Talose)

Deoxysaccharides (Fucose, Fuculose, Rhamnose)

Heptoses Ketoheptose (Sedoheptulose, Mannoheptulose)
> 7 Octoses Nanoses (Neuraminic acid)
Carbohydrate derivatives