Diovan – Uses, Side Effects, Interactions

How does this medication work? What will it do for me?

Valsartan belongs to a family of medications known as angiotensin II receptor blockers. These medications are used to lower mild-to-moderate high blood pressure. Valsartan is also used to treat chronic heart failure or to reduce the risk of death after a heart attack for people who cannot use another type of medication called an angiotensin-converting enzyme inhibitor.

Angiotensin II is a chemical that the body releases to cause the constriction of blood vessels. Valsartan blocks the action of angiotensin II, resulting in the relaxation of the blood vessels. This relaxation causes the blood pressure to drop. The full effects of valsartan are usually seen within 4 weeks. Valsartan may be used alone or in combination with a diuretic (water pill).

This medication may be available under multiple brand names and/or in several different forms.  Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

What form(s) does this medication come in?

40 mg
Each yellow, ovaloid, scored on one side, slightly convex tablet with bevelled edges, debossed on one side with “DO” and with “NVR” on the other side, contains valsartan 40 mg.  Nonmedicinal ingredients: colloidal silicon dioxide, crospovidone, magnesium stearate, and microcrystalline cellulose; coating: black iron oxide, hydroxypropyl methylcellulose, polyethylene glycol, red iron oxide, titanium dioxide, and yellow iron oxide.

80 mg
Each pale red, round tablet with bevelled edges, debossed with “DV” on one side and “NVR” on the other, contains valsartan 80 mg. Nonmedicinal ingredients: colloidal silicon dioxide, crospovidone, magnesium stearate, and microcrystalline cellulose; coating: black iron oxide, hydroxypropyl methylcellulose, polyethylene glycol, red iron oxide, and titanium dioxide.

160 mg
Each grey orange, ovaloid tablet with bevelled edges, debossed with “DX” on one side and “NVR” on the other, contains valsartan 160 mg. Nonmedicinal ingredients: colloidal silicon dioxide, crospovidone, magnesium stearate, and microcrystalline cellulose; coating: black iron oxide, hydroxypropyl methylcellulose, polyethylene glycol, red iron oxide, titanium dioxide, and yellow iron oxide.

320 mg
Each dark grey-violet, ovaloid tablet with bevelled edges, debossed with “DXL” on one side and “NVR” on the other, contains valsartan 320 mg. Nonmedicinal ingredients: colloidal silicon dioxide, crospovidone, magnesium stearate, and microcrystalline cellulose; coating: black iron oxide, hydroxypropyl methylcellulose, polyethylene glycol, red iron oxide, titanium dioxide, and yellow iron oxide.

How should I use this medication?

To treat high blood pressure, the recommended starting dose of valsartan is 80 mg once daily. Reductions in blood pressure are often seen within 2 weeks, and the full effects on blood pressure are seen in about 4 weeks. Your doctor may recommend a dose increase if your blood pressure remains too high. The maximum recommended dose is 320 mg daily. A diuretic may also be added to help reduce blood pressure.

To treat heart failure, the recommended starting dose is 40 mg twice daily. This dose is then increased gradually to a maximum recommended dose of 160 mg twice daily.

After a heart attack, the recommended starting dose of valsartan is 20 mg twice daily. Your doctor may increase the dose slowly over 1 to 2 weeks to a target dosage of 160 mg twice daily if tolerated. Other medications, such as beta-blockers, may be taken in addition to valsartan to further reduce the risk of another heart attack.

Valsartan may be taken with or without food, but it should be taken the same way each day.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, skip the missed dose and continue with your regular dosing schedule.  Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature and away from moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Who should NOT take this medication?

Do not take valsartan if you:

• are allergic to valsartan or any ingredients of the medication
• have experienced angioedema as a reaction to any Angiotensin Receptor Blocker (ARB)
• are pregnant or breast-feeding
• are taking aliskiren and have diabetes or decreased renal function

What side effects are possible with this medication?

Many medications can cause side effects.  A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• back or leg pain
• cough
• decreased interest in sexual activity
• decreased sexual ability
• diarrhea
• difficulty sleeping
• dizziness or lightheadedness when rising from a lying or sitting position
• drowsiness
• flu-like symptoms (sudden lack of energy, fever, cough, sore throat)
• headache
• muscle cramps
• nausea
• unusual tiredness or weakness
• vomiting

Although most of the side effects listed below don’t happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• abdominal pain
• fainting
• increased frequency of cold symptoms (ear, head, and nose congestion; sneezing; sore throat; fever)
• irregular heartbeat
• rash
• signs of anemia (low red blood cells; e.g., dizziness, pale skin, unusual tiredness or weakness, shortness of breath)
• signs of bleeding (e.g., bloody nose, blood in urine, coughing blood, bleeding gums, cuts that don’t stop bleeding)
• signs of heart problems (e.g., difficulty breathing when lying down, swelling feet or ankles, tiring easily)
• signs of kidney problems (e.g., decreased urination, nausea, vomiting, swelling of the feet and ankles)
• signs of inflamed blood vessels (e.g., purplish-red spots, fever, itching)
• signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
• signs of too much potassium in the body (e. g., irregular heartbeat, muscle weakness, generally feeling unwell)
• unexplained muscle pain or weakness

Stop taking the medication and seek immediate medical attention if any of the following occur:

• signs of a serious allergic reaction (e.g., swelling of face or throat, hives, or difficulty breathing)
• signs of a severe skin reaction such as blistering, peeling, a rash covering a large area of the body, a rash that spreads quickly, or a rash combined with fever or discomfort

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Are there any other precautions or warnings for this medication?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Drowsiness/reduced alertness: Valsartan may cause drowsiness or dizziness, affecting your ability to drive or operate machinery. Avoid these and other hazardous tasks until you have determined how this medication affects you.

Kidney problems: Valsartan may affect the function of the kidneys, especially for people who already have kidney problems. Certain people have experienced changes in kidney function (e.g., people with narrowed blood vessels in their kidneys, or those with severe congestive heart failure). The use of diuretics (water pills), nonsteroidal anti-inflammatory drugs (NSAIDs), or aliskiren can further increase the risk of kidney problems.

If you have reduced kidney function or kidney disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Liver function: Valsartan is broken down by the liver. Liver disease or reduced liver function may cause this medication to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking this medication.

This medication may also cause a decrease in liver function. If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.

Low blood pressure: Occasionally, a larger-than-expected decrease in blood pressure occurs after taking valsartan. In some cases, this happens after the first dose. It is more likely to occur if you take diuretics (water pills), are taking aliskiren, have a reduced salt intake, are on dialysis, or are experiencing diarrhea or vomiting. Blood pressure should be monitored more often in these situations. Those who have low blood pressure or are just starting this medication should move slowly from a reclining to an upright position to reduce the risk of dizziness.

Pregnancy: Valsartan should not be taken by pregnant women as it can cause harm to an unborn child. If you are planning to become pregnant, discuss alternative medications for blood pressure control with your doctor. If you become pregnant while taking this medication, stop taking it and tell your doctor at once.

Breast-feeding: It is not known if valsartan passes into breast milk. If you are breast-feeding and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of this medication have not been established for children.

What other drugs could interact with this medication?

There may be an interaction between valsartan and any of the following:

• aldesleukin
• aliskiren
• alpha-agonists (e.g., clonidine, methyldopa)
• alpha-blockers (e.g., alfuzosin, doxazosin, tamsulosin)
• amiodarone
• amphetamines (e.g., dextroamphetamine, lisdexamfetamine)
• angiotensin converting enzyme inhibitors (ACEIs; e.g., captopril, lisinopril, ramipril)
• other angiotensin receptor blockers (ARBs; e.g., candesartan, irbesartan, losartan)
• antipsychotics (e.g., chlorpromazine, clozapine, haloperidol, olanzapine, quetiapine, risperidone)
• barbiturates (e.g., butalbital, pentobarbital, phenobarbital)
• beta-adrenergic blockers (e.g., atenolol, propranolol, sotalol)
• brimonidine
• bromocriptine
• calcium channel blockers (e. g., amlodipine, diltiazem, nifedipine, verapamil)
• ceritinib
• conivaptan
• cyclosporine
• dexmethylphenidate
• digoxin
• diuretics (water pills; e.g., furosemide, hydrochlorothiazide, indapamide)
• donepezil
• dronedarone
• drospirenone
• duloxetine
• eltrombopag
• eplerenone
• fingolimod
• galantamine
• gemfibrozil
• guanfacine
• heparin and low-molecular weight heparins (e.g., dalteparin, tinzaparin)
• hydralazine
• iron sucrose
• levodopa
• lithium
• methylphenidate
• monoamine oxidase inhibitors (MAOIs; e.g., moclobemide, phenelzine, rasagiline, selegiline, tranylcypromine)
• morphine
• medications that increase the level of potassium in the blood (e.g., spironolactone, amiloride, triamterene, or salt substitutes that contain potassium)
• nabilone
• nitrates (e.g., nitroglycerin, isosorbide dinitrate, isosorbide mononitrate)
• non-steroidal anti-inflammatory medications (NSAIDs; e. g., diclofenac, ibuprofen, naproxen)
• obinutuzumab
• paclitaxel
• pentoxifylline
• phosphodiesterase 5 inhibitors (e.g., sildenafil, tadalafil, vardenafil)
• potassium supplements
• pramipexole
• rasagiline
• riociguat
• rivastigmine
• sacubitril
• sodium phosphates
• somatostatin-like medications (e.g., lanreotide, octreotide, pasireotide)
• tacrolimus
• teriflunomide
• tolvaptan
• trimethoprim
• yohimbine

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them.  Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

All material copyright MediResource Inc. 1996 – 2023. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/drug/getdrug/Diovan

Diovan 160Mg Tablet – Uses, Side Effects, Substitutes, Composition And More

Manufacturer: Novartis India Ltd

Medicine composition: Valsartan

Prescription vs OTC: Prescription by Doctor required

Diovan 160Mg Tablet is essentially a combination drug which is used in the treatment of hypertension. The drug is prescribed to patients who have already experienced a heart attack. It control blood sugar levels in the body and relaxes the heart, thus reducing the risk of another attack.

This medicine should not be taken by people who are allergic to any component it has. Pregnant women and children with renal disease are also discouraged from taking this medication.

The drug comes with an instructions leaflet, which should be read carefully before using it. Also, make sure that you take the exact dosage that is mentioned in the prescription. Overdosage can lead to severe complications.

Drowsiness and dizzy spells are common side effects of this medication. In this case, patients should avoid driving and indulging in unsafe activities for some time, until they get used to the feeling.

In case you are undergoing dental treatment or some other form of procedure, make sure you inform the doctor that you are taking this medicine. Some lab tests are done regularly to check the effects of Diovan 160Mg Tablet on the body. Do not miss any of the tests.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Cardiologist before using this medicine.

The medication is used for the treatment of conditions like:

Health issues vary person to person

Take help from the best doctors

• Is It safe with alcohol?

  Taking this medicine with alcohol may have additive effects in lowering blood pressure. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate.

• Are there any pregnancy warnings?

  This medicine is unsafe to use during pregnancy.
  There is positive evidence of human fetal risk, but the benefits from use in pregnant women may be acceptable despite the risk, for example in life-threatening situations. Please consult your doctor.

• Are there any breast-feeding warnings?

  Unknown. Human and animal studies are not available. Please consult your doctor.

• Is it safe to drive while on this medicine?

  Occasionally dizziness or weariness may occur.

• Does this affect kidney function?

  Caution should be used in patients with impaired renal function.

• Does this affect liver function?

  There is no data available. Please consult doctor before consuming the drug.

• What is the onset of action?

  The action is initiated within 60 min after its administration.

• How long is the duration of effect?

  This medicine produces its action for about 12 – 15 hrs after its administration.

Below is the list of medicines, which have the same composition, strength and form as Diovan 160Mg Tablet , and hence can be used as its substitute.

This medication falls under the category of antihypertensives, belonging to the class of an ARBs. It brings about inhibition of combination to angiotensin II to AT1 selectively. This occurs within many tissues such as adrenal glands and smooth vascular muscles.

What are the interactions of Diovan 160Mg Tablet ?

Whenever you take more than one medicine, or mix it with certain foods or beverages, you”re at risk of a drug interaction.

References

• Valsartan-Drug Information Portal [Internet].druginfo.nlm.nih.gov 2022 [Cited 20 June 2022].Available from:

  https://druginfo.nlm.nih.gov/drugportal/name/valsartan

• Valsartan-DrugBank Online [Internet].

  go.drugbank.com 2022 [Cited 20 June 2022].Available from:

  https://go.drugbank.com/drugs/DB00177

• HYDROCHLOROTHIAZIDE tablet,solution-DailyMed [Internet].dailymed.nlm.nih.gov 2022 [Cited 20 June 2022].Available from:

  https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=HYDROCHLOROTHIAZIDE

Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

Popular Questions & Answers

Does radiation therapy to the neck and hypothyroidism cause the blood pressure to rise? After my RT last Dec, my blood pressure has elevated. Now after every meal (chewing and swallowing), my blood pressure elevates to 150/110. I am on Diovan but it does not help.

Hello ,It may happen so,hypothyroidism may cause, Hypertension but after mastication and swallowing, if your BP is raised, u need to consult some cardiologist, soon.

My mom is 90 years old, she is on wheelchair as she had stroke in 2005 after that she became semi paralyzed, she is on medication since, she diabetic 2 and she takes diamicron Mr.

60 mg (gliclazide) 1 daily before breakfast and diovan 160 mg for high blood pressure and takes warfarin 3 mg after lunch the question is my mom is suffering from hallucinations since last year, does that have anything to do with the medication she is taking? Thank you.

Dr. Prakhar Singh

MBBS, Basic Life Support (B.L.S), Advanced Cardiac Life Support, Fellow of Academy of General Education (FAGE)

General Physician, Delhi

Brain disease or brain damage can cause changes in brain function and produce hallucinations; – Fever as a result of infection can cause hallucinations in children and older people. Let’s have a detailed discussion for better advice and healthy li…

Hi, My father is suffering from systolic hypertension. He is diagnosed 3 years back.

The hypertension history is first he was given with amlodipine+valsartan 5/80 mg (exforge) before sleep when he take that medicine his systolic blood pressure become normal but diastolic decreases to 50 or less then the medication was changed and he started with amlodipine 5 mg (Norvasc) before sleep but the problem remains same then the physician changed it from 5 mg to Amlodipine 2.5 mg (Lodopin) before sleep but the problem remain same and there was no success. We were referred to cardiologist who after taking the echo and ecg said that he is having no cardiac issues and suggested losartan 50 mg (eziday) before sleep. Now with this medication the issue is that his diastolic comes to normal if he takes medicine but systolic is going high up to 175 – 185 then he changes it to valsartan 80 mg (diovan) before sleep but the problem remain same with this medicine but the slight change that appears is his blood pressure remains normal till mid day and after mid day it starts going up and till night it again reaches to 165-175.
I want to ask is there any solution for the above case. Your response will be much appreciated.

Dr. Rajiv Bajaj

MBBS, MD – Internal Medicine, DM – Cardiology, Fellowship in EP

Cardiologist, Delhi

Go back to amlodipine. Keep systolic BP less than 150. Ignore diastolic BP. Measure his BP only once every two weeks on fixed dates after resting for ten minutes. Completely avoid measuring at any other time.

Is it safe to take nurokind plus rf with valsartan and metformin medication diabetics.

Dr. Prabhakar Laxman Jathar

MBBS, CCEBDM, Diploma in Diabetology, Diploma in Clinical Nutrition & Dietetics, Cetificate Course In Thyroid Disorders Management (CCMTD)

Endocrinologist, Dharwad

Hello, thanks for the query. Yes it is quite safe to take the mentioned medication with other treatment which is on. Thanks.

View All Questions & Answers

Popular Health Tips

Heart Failure – 4 Possible Causes Behind It!

Heart failure, which is also known as congestive heart failure, occurs when the heart muscle fails to pump sufficient blood as well as it should. The narrowed arteries in one s heart or high blood pressure make the heart too weak to pump sufficien…

1510
people found this helpful

Chronic Nephritis – How To Cope With It?

Chronic nephritis is a type of Glomerulonephritis (GN). In this condition, irritation takes place in the Glomeruli, which are parts in your kidneys comprising tiny blood vessels. These knots of vessels filter your blood and remove excess fluids fr…

2098
people found this helpful

Heart Failure – 4 Possible Causes Behind It!

Heart failure, which is also known as congestive heart failure, occurs when the heart muscle fails to pump sufficient blood as well as it should. The narrowed arteries in one s heart or high blood pressure make the heart too weak to pump sufficien…

2681
people found this helpful

View All Health Tips

Content Details

Written By

Drx Hina Firdous

PhD (Pharmacology) Pursuing, M. Pharma (Pharmacology), B.Pharma – Certificate in Nutrition and Child Care

Pharmacology

Reviewed By

Dr. Garima Sharma

MBBS, Master in Healthcare Administration, Diploma in Occupational Health

General Physician

Table of Content

About Diovan 160Mg Tablet

What are the uses of Diovan 160Mg Tablet

What are the contraindications of Diovan 160Mg Tablet ?

What are the side effects of Diovan 160Mg Tablet ?

Key highlights of Diovan 160Mg Tablet

What are the substitutes for Diovan 160Mg Tablet ?

What are the dosage instructions?

How does this medication work?

What are the interactions of Diovan 160Mg Tablet ?

Book appointment with

Top Cardiologist in Delhi
Top Cardiologist in Mumbai
Top Cardiologist in Gurgaon
Top Cardiologist in Pune
Top Cardiologist in Kolkata
Top Cardiologist in Bangalore
Top Cardiologist in Chennai
Top Cardiologist in Hyderabad

Diovan instructions for use: indications, contraindications, side effects – description Diovan tab.

, cover. shell, 160 mg: 14, 28, 56 or 98 pcs. (24688)

💊 Composition of Diovan ® ✅ Application of Diovan ® Keep it for yourself Look for alternatives Interaction Description of the active ingredients of the preparation Diovan ® (Diovan ® ) The scientific information provided is general and cannot be used to make decisions. decisions about the use of a particular drug. Renewal date: 2020. 03.25 Marketing authorization holder: NOVARTIS PHARMA, AG (Switzerland) Made: NOVARTIS FARMACEUTICA, S.A. (Spain) ATX code: C09CA03 (Valsartan) Active substance: valsartan (valsartan) Rec.INN WHO registered Dosage form Diovan ® Tab., coated shell, 160 mg: 14, 28, 56 or 98 pcs. reg. No.: P N013991/01 dated 13. 11.09 – Indefinitely Date of re-registration: 16.02.16 Release form, packaging and composition Diovan ® film-coated tablets, grey-orange, oval, scored on one side and embossed with “DX/DX”, on the other side with “NVR”. Excipients : microcrystalline cellulose, crospovidone, anhydrous colloidal silicon dioxide, magnesium stearate, hypromellose (hydroxypropyl methylcellulose), macrogol 8000, titanium dioxide (E171), iron oxide red (E172), iron oxide yellow (E172), iron oxide black (E172). 14 pcs. – blisters (1) – packs of cardboard. 14 pcs. – blisters (2) – packs of cardboard. 14 pcs. – blisters (4) – packs of cardboard. 14 pcs. – blisters (7) – packs of cardboard. Clinical and pharmacological group: Angiotensin II receptor antagonist Pharmacotherapeutic group: Angiotensin II receptor antagonist Pharmacological action Antihypertensive agent. It is a specific angiotensin II receptor antagonist. It has a selective antagonistic effect on AT 1 – receptors that are responsible for the implementation of the effects of angiotensin II. Due to the blockade of AT 1 receptors, the plasma concentration of angiotensin II increases, which can stimulate unblocked AT 2 receptors. It does not have agonistic activity against AT 1 receptors. The affinity of valsartan for the AT 1 receptor is approximately 20,000 times higher than for the AT 2 receptor. Does not inhibit ACE. Does not interact with or block other hormone receptors or ion channels that are important for the regulation of the functions of the cardiovascular system. Does not affect the level of total cholesterol, TG, glucose and uric acid in plasma. The onset of the antihypertensive effect of valsartan after its oral administration in a single dose is observed within 2 hours after administration, the maximum effect is achieved within 4-6 hours. Pharmacokinetics . Absolute bioavailability averages 23%. The pharmacokinetic curve of valsartan has a multi-exponential character (T 1/2 in the α-phase < 1 h and T 1/2 in the β-phase – about 9 h), the kinetics is linear. There were no changes in pharmacokinetic parameters during the course application. When taking valsartan with food, AUC decreases by 48%, while approximately 8 hours after taking valsartan plasma concentrations are the same in patients who took it with food and on an empty stomach. The decrease in AUC is not accompanied by a clinically significant decrease in the therapeutic effect. When taking valsartan 1 time / day, cumulation is slightly pronounced. Plasma concentrations of valsartan in women and men were the same. Plasma protein binding, predominantly to albumin, is 94-97%. V d in the equilibrium state is about 17 liters. Plasma clearance of valsartan is about 2 l/h. Excreted with feces – 70% and with urine – 30%, mainly unchanged. In biliary cirrhosis or obstruction of the biliary tract, the AUC of valsartan increases by approximately 2 times. Indications of the active substances of the drug Diovan ® Treatment of arterial hypertension. Treatment of chronic heart failure (NYHA functional class II-IV) in patients receiving conventional therapy with diuretics, digitalis preparations, and ACE inhibitors or beta-blockers. Open list of ICD-10 codes I10 Essential [primary] hypertension I50.0 Congestive heart failure Dosing regimen The method of administration and dosing regimen of a particular drug depends on its form of release and other factors. The optimal dosage regimen is determined by the doctor. Compliance of the dosage form of a particular drug with indications for use and dosing regimen should be strictly observed. Take orally at a dose of 80 mg 1 time / day or 40 mg 2 times / day, daily. In the absence of an adequate effect, the daily dose may be gradually increased. The maximum daily dose of is 320 mg in 2 divided doses. Side effects From the side of the cardiovascular system: arterial hypotension, postural dizziness, postural hypotension. From the side of the central nervous system: dizziness, headache. From the digestive system: diarrhea, nausea, increased bilirubin levels. From the urinary system: rarely – impaired renal function, increased levels of creatinine and urea nitrogen (especially in chronic heart failure). From the side of metabolism: hyperkalemia. From the side of the hematopoietic system: neutropenia, decrease in hemoglobin and hematocrit. Allergic reactions: rarely – angioedema, rash, itching, serum sickness, vasculitis. Other: fatigue, general weakness, cough, pharyngitis, increased risk of viral infections. Contraindications for use Pregnancy, hypersensitivity to valsartan. Use in pregnancy and lactation Valsartan is contraindicated in pregnancy. It is not known whether valsartan is excreted in human breast milk. Use during lactation (breastfeeding) is not recommended. In experimental studies valsartan has been shown to be excreted in breast milk in rats. Use in impaired renal function In patients with renovascular hypertension secondary to renal artery stenosis, serum urea and creatinine levels should be monitored regularly during treatment. Data on the safety of use in patients with CC less than 10 ml / min are not available. Due to inhibition of the RAAS in predisposed patients, changes in renal function are possible. Use in children The safety and efficacy of valsartan in children has not been established. Special instructions With hyponatremia and / or a decrease in BCC, as well as during therapy with high doses of diuretics, in rare cases, valsartan can cause severe arterial hypotension. Before starting treatment, correction of water-salt metabolism disorders should be carried out. In patients with renovascular hypertension secondary to renal artery stenosis, serum urea and creatinine levels should be regularly monitored during treatment. Data on the safety of use in patients with CC less than 10 ml / min are not available. Use with extreme caution in patients with biliary obstruction. Due to inhibition of the RAAS in predisposed patients, changes in renal function are possible. When using ACE inhibitors and angiotensin receptor antagonists in patients with severe chronic heart failure, oliguria and / or an increase in azotemia were observed, and acute renal failure with a risk of death rarely developed. The safety and efficacy of valsartan in children has not been established. Influence on the ability to drive vehicles and mechanisms When using valsartan, it is recommended to be careful when driving a car and operating mechanisms. Drug interactions With the simultaneous use of diuretics in high doses, arterial hypotension may develop. With the simultaneous use of potassium-sparing diuretics, heparin, dietary supplements or salt substitutes containing potassium, hyperkalemia may develop. Co-administration with indomethacin may reduce the antihypertensive effect of valsartan. When used simultaneously with lithium carbonate, a case of lithium intoxication has been described. Keep If you want to place a link to the description of this drug – use this code Diovan ® . Description of the drug in the reference book Vidal.

Diovan instruction, price in pharmacies of Ukraine

Dosage

• Valsartan: 80 mg/tablet (1)
• Valsartan: 160 mg/tablet (1)

---

Who can

• Seniors (2)
• Children (1)
• Allergics (2)
• Diabetics m (2)
• Water (2)

---

• Product list
• Instructions

• Prices in pharmacies

• Analogues

Item: 2

Sorting:
Behind the ratingVid cheapVid expensive

Go to box

Go to box

Analogs

Show all

---

Go to box

Go to box

Go to cat

Editorial team

Creation date: 04/27/2021
Update date: 06/28/2023

Warehouse and release form

warehouse:

1 tablet Diovan 40 to valsartan 0. 04 g; additional components:

• MCC, crospovidone, aerosil, hydromelose, magnesium stearate, black oxide saliva, macrogol 8000, yellow saliva oxide, titanium dioxide, saliva chervonium oxide.

1 tablet Diovan 80 revenge valsartan 0.08 g; additional components:

• MCC, crospovidone, aerosil, hydromelose, magnesium stearate, macrogol 8000, saline yellow oxide, titanium dioxide, saline chervonium oxide,

1 tablet Diovan 160 valsartan 0.16 g; additional components:

• MCC, crospovidone, aerosil, hydromelose, magnesium stearate, saliva black oxide, macrogol 8000, saliva zhovtium oxide, titanium dioxide, saliva chervonium oxide.

1 tablet Diovan 320 to revenge valsartan 0.32 g; additional components:

• MCC, crospovidone, aerosil, hydromelose, magnesium stearate, saliva black oxide, macrogol 8000, saliva zhovtium oxide, titanium dioxide, saliva chervonium oxide.

Dispensing form:

Diovan is dispensed in four dosed tablets. Packing for skin feet:

• 14 tab. / Package;
• 28 tab. / Package;
• 56 tab. / Package;
• 98 tab. / Package.

Pharmacological action

Valsartan has a selective antagonistic action in relation to the angiotensin II receptor. Inducing blocking of AT1 receptors, and, as a result, increases the concentration of antitensin II. Agonistic activity to AT 1 receptors is not suspected.

Consumption of the drug is accompanied by a decrease in arterial pressure. On the heart rate, the injection was not observed. After 2 years after the reception, an antihypertensive effect is achieved. Diya trivala, need dobu. Reactions kasuvannya for Diovan uncharacteristic.

In CHF, the drug helps to reduce the effects of RAAS hyperstimulation; remove vasoconstriction; to bring back the homeland; avoid cellular proliferation, which leads to organ remodeling; superfluous secretion of catecholamines, vasopressin, aldosterone, endothelin. The drug changes the predilection, DZLK, increases the heart rate. Injection into the place of cholesterol, sechovoy acid does not hurt.

Reducing the number of hospitalizations of patients with CHF, improving the quality of their lives; ignoring the progression of heart failure, reducing the risk of post-infarction complications during the usual therapy with captopril.

Indications

Diovan Indications for:

• arterial hypertension;
• CHF II-IV functional class;
• acute myocardial infarction with levoventricular insufficiency;
• systolic dysfunction of the left duct (as hemodynamics is stable).

Dosing

Diovan tablets are taken inside. Rozhovuvannya is not allowed. The recommended dose for hypertension is 80 mg/day. For the presence of sufficient therapeutic efficacy, dosing is exchanged. Maximum zbіlshennya – up to 640 mg / dose. Robe step by step. The manifestations of the effect are observed after a month of therapy.

In the post-infarction period, start therapy in the first 12 years – 40 mg / dose (½ tablet Diovan 40 2 times a day). Doses are titrated from 40 mg/dose up to 320 mg/dose. In case of hypotension, a decision is made about lowering the dosage.

Adverse reactions

Consumption of Diovan may be associated with:

• viral infections;
• neutropenia;
• pharyngitis;
• swagger;
• thrombocytopenia;
• sinusitis;
• postural confusion;
• asthenia;
• vertigo;
• hypersensitivity reactions;
• rhinitis;
• urge;
• hyperkalemia;
• coughing;
• not tired;
• syrovatkovy ailment;
• sleepless;
• broken functions of nirok;
• low libido;
• diarrhea;
• headache;
• orthostatic hypotension;
• arterial hypotension;
• epigastric pain;
• arthralgia;
• in a blur;
• heart failure;
• vasculitis;
• visipom;
• state of nirk deficiency;
• myalgia;
• reduced hemoglobin concentration;
• scribbles;
• back pain;
• changed hematocrit.

Contraindication

Do not prescribe Diovan if:

• vagity;
• hypersensitivity to valsartan;
• lactations;
• increased sensitivity to additional components.

For protection, the drug is prescribed for:

• stenosis of the artery of the nirk, as if the patient had only one;
• hyposodium diet;
• aquatic;
• obstruction of the zhovchevidnyh passages;
• severe neurological deficiency;
• cases in patients, which could prevent hemodialysis.

vaccinia:

The drug may not be safe for the fetus. Valsartan containing bones are not prescribed.

Interaction

Drug, drug group	Possible result of interaction with valsartan
potassium-sparing diuretics	Increased serum-wool concentration of potassium
potassium preparations	Increased serum-wool concentration of potassium
lithium preparations	Increased plasma concentration with lithium, increased toxicity
NPZZ	Decreased antihypertensive effect, decreased performance
diuretics	Improvement of hypotensive effect

Overdose

In case of overdosing of therapeutic doses, hypotension, possible collapse, shock state are manifested.