What are the primary uses of Maxalt 10 mg. How does rizatriptan work to alleviate migraine symptoms. What are the potential side effects of Maxalt. How should Maxalt be taken for optimal effectiveness.

Understanding Maxalt: A Powerful Migraine Relief Medication

Maxalt, containing the active ingredient rizatriptan, is a widely prescribed medication for the treatment of migraines. As a member of the triptan class of drugs, it offers relief from the debilitating symptoms associated with migraine attacks. Maxalt works by targeting specific receptors in the brain, providing rapid and effective relief for many sufferers.

How Does Maxalt Work?

Rizatriptan, the key component of Maxalt, functions by influencing serotonin levels in the brain. This neurotransmitter plays a crucial role in regulating pain signals and blood vessel constriction. By targeting serotonin receptors, Maxalt helps to:

• Narrow blood vessels in the brain
• Reduce inflammation in the affected area
• Alleviate pain signals transmitted through nerve endings

This multi-faceted approach allows Maxalt to address various aspects of migraine symptoms effectively.

Proper Usage and Dosage Guidelines for Maxalt

To ensure optimal effectiveness and safety, it’s crucial to follow the prescribed dosage and administration guidelines for Maxalt. How should you take Maxalt for the best results? Maxalt should be taken orally at the first sign of a migraine attack. It can be consumed with or without food, although taking it on an empty stomach may lead to faster absorption.

Dosage Recommendations

The appropriate dosage of Maxalt varies based on several factors, including:

• Age
• Weight (particularly for children)
• Overall health condition
• Response to treatment
• Other medications being taken

For adults, the typical recommended dose is 5-10 mg, with a maximum of 30 mg in a 24-hour period according to US guidelines. Canadian guidelines suggest a maximum of 20 mg for adults within 24 hours. Children’s dosages are weight-based and should not exceed 5 mg in a 24-hour period.

Timing of Doses

Can you take multiple doses of Maxalt if needed? If symptoms persist or only partially improve, adults may take a second dose at least 2 hours after the initial dose. However, it’s crucial to consult with a healthcare provider before increasing dosage or frequency of use.

Potential Side Effects and Precautions

While Maxalt is generally well-tolerated, it’s essential to be aware of potential side effects and take necessary precautions. What are the common side effects of Maxalt? Some individuals may experience:

• Flushing
• Tingling or numbness
• Fatigue or weakness
• Drowsiness or dizziness

These effects are usually mild and transient. However, if they persist or worsen, it’s important to consult a healthcare provider.

Serious Side Effects to Watch For

In rare cases, Maxalt may cause more serious side effects. What are the signs of severe adverse reactions to Maxalt? Be alert for symptoms such as:

• Chest pain or pressure
• Jaw or neck tightness
• Rapid or irregular heartbeat
• Severe abdominal pain
• Signs of stroke (weakness on one side, difficulty speaking, vision changes)

If any of these symptoms occur, seek immediate medical attention.

Maxalt and Cardiovascular Health

Individuals with a history of cardiovascular issues should exercise caution when using Maxalt. How does Maxalt affect heart health? The medication can potentially raise blood pressure and cause vasoconstriction, which may pose risks for those with pre-existing heart conditions.

For patients with higher cardiovascular risk factors, healthcare providers may recommend a thorough heart examination before prescribing Maxalt. In some cases, the first dose may be administered under medical supervision to monitor for any adverse reactions.

Interactions and Contraindications

Maxalt may interact with various medications and substances, potentially altering its effectiveness or increasing the risk of side effects. What are the key drug interactions to be aware of with Maxalt?

• Other serotonin-increasing medications
• Monoamine oxidase inhibitors (MAOIs)
• Certain antidepressants
• Ergotamine-containing drugs

It’s crucial to inform your healthcare provider about all medications, supplements, and herbal products you’re taking to avoid potential interactions.

Serotonin Syndrome Risk

One of the more serious potential complications associated with Maxalt is serotonin syndrome. What is serotonin syndrome, and how can it be recognized? This rare but potentially life-threatening condition occurs when serotonin levels in the body become excessively high. Symptoms may include:

• Rapid heartbeat
• Hallucinations
• Loss of coordination
• Severe dizziness
• Nausea, vomiting, or diarrhea
• Muscle twitching
• Unexplained fever
• Unusual agitation or restlessness

If you experience any of these symptoms while taking Maxalt, seek immediate medical attention.

Long-term Use and Medication Overuse Headache

While Maxalt can be highly effective for acute migraine relief, it’s important to be cautious about long-term and frequent use. Can regular use of Maxalt lead to complications? Overuse of migraine medications, including Maxalt, can potentially lead to a condition known as medication overuse headache (MOH).

MOH occurs when pain relief medications are used too frequently, typically on 10 or more days per month. This can result in:

• Increased frequency of headaches
• Reduced effectiveness of the medication
• Dependence on the medication for pain relief

To prevent MOH, it’s crucial to follow prescribed guidelines and avoid using Maxalt or other migraine medications more often than recommended. If you find yourself needing to use Maxalt more frequently, consult your healthcare provider for alternative management strategies.

Maxalt in Special Populations

The use of Maxalt may require special considerations for certain groups of people. How does Maxalt usage differ for various populations?

Children and Adolescents

Maxalt is approved for use in children aged 6 to 17 years old. However, dosing is weight-based and typically lower than adult doses. It’s crucial to follow pediatric-specific guidelines when administering Maxalt to younger patients.

Pregnant and Breastfeeding Women

The safety of Maxalt during pregnancy and breastfeeding has not been definitively established. Women who are pregnant, planning to become pregnant, or breastfeeding should consult their healthcare provider before using Maxalt to weigh the potential risks and benefits.

Older Adults

Elderly patients may be more sensitive to the effects of Maxalt and may require dose adjustments. Additionally, the risk of cardiovascular side effects may be higher in this population, necessitating closer monitoring.

Alternatives and Complementary Approaches to Migraine Management

While Maxalt can be an effective treatment for acute migraine attacks, it’s often part of a broader management strategy. What other approaches can complement or serve as alternatives to Maxalt for migraine relief?

• Preventive medications: These are taken regularly to reduce the frequency and severity of migraine attacks.
• Lifestyle modifications: Identifying and avoiding triggers, maintaining regular sleep patterns, and stress management can help reduce migraine occurrences.
• Non-pharmacological therapies: Techniques such as acupuncture, biofeedback, and cognitive behavioral therapy have shown promise in migraine management.
• Dietary adjustments: Some individuals find relief by avoiding certain foods or additives that may trigger migraines.
• Alternative medications: For those who cannot take or do not respond well to triptans like Maxalt, other classes of medications may be considered.

A comprehensive migraine management plan often involves a combination of these approaches, tailored to the individual’s specific needs and response to treatment.

In conclusion, Maxalt 10 mg is a potent and widely used medication for acute migraine relief. Its effectiveness in alleviating migraine symptoms makes it a valuable tool in the management of this debilitating condition. However, like all medications, it comes with potential side effects and considerations for use. By understanding how Maxalt works, following proper usage guidelines, and being aware of potential risks and interactions, patients can maximize the benefits of this medication while minimizing potential complications. As always, it’s crucial to work closely with healthcare providers to develop a personalized and effective migraine management strategy that may include Maxalt as part of a broader treatment approach.

Maxalt Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Uses

Rizatriptan is used to treat migraines. It helps to relieve headache, pain, and other migraine symptoms (including nausea, vomiting, sensitivity to light/sound). Prompt treatment helps you return to your normal routine and may decrease your need for other pain medications. Rizatriptan belongs to a class of drugs known as triptans. It affects a certain natural substance (serotonin) that causes narrowing of blood vessels in the brain. It may also relieve pain by affecting certain nerves in the brain.Rizatriptan does not prevent future migraines or lessen how often you get migraine attacks.

How to use Maxalt

Read the Patient Information Leaflet if available from your pharmacist before you start taking rizatriptan and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth as directed by your doctor, at the first sign of a migraine. It may be taken with or without food, but may work faster when it is taken on an empty stomach. The dosage is based on your medical condition, age, response to treatment, and other drugs you may be taking. For children, the dosage is also based on weight. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

If there is no improvement in your symptoms, do not take more doses of this medication before talking to your doctor. If your symptoms are only partly relieved, or if your headache comes back, adults may take another dose at least 2 hours after the first dose. Children should not take more than one dose, or 5 milligrams in a 24-hour period. For adults, the US manufacturer recommends a maximum dose of 30 milligrams in a 24-hour period. The Canadian manufacturer recommends a maximum dose of 20 milligrams (for adults) in a 24-hour period.

If you have a higher risk for heart problems (see Precautions), your doctor may perform a heart exam before you start taking rizatriptan. He/she may also direct you to take your first dose of this medication in the office/clinic to monitor for serious side effects (such as chest pain). Talk to your doctor for details.

If you are using drugs for migraine attacks on 10 or more days each month, the drugs may actually make your headaches worse (medication overuse headache). Do not use medications more often or for longer than directed. Tell your doctor if you need to use this medication more often, or if the medication is not working as well, or if your headaches get worse.

Side Effects

Flushing, feelings of tingling/numbness/prickling/heat, tiredness, weakness, drowsiness, or dizziness may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

This medication may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high.

Tell your doctor right away if you have any serious side effects, including: blue fingers/toes/nails, cold hands/feet, hearing changes, mental/mood changes.

Rizatriptan can commonly cause chest/jaw/neck tightness, pain, or pressure that is usually not serious. However, these side effects are like symptoms of a heart attack, which may include chest/jaw/left arm pain, shortness of breath, or unusual sweating. Get medical help right away if these or other serious side effects occur, including: fast/irregular heartbeat, fainting, severe stomach/abdominal pain, bloody diarrhea, signs of a stroke (such as weakness on one side of the body, trouble speaking, sudden vision changes, confusion).

This medication may increase serotonin and rarely cause a very serious condition called serotonin syndrome/toxicity. The risk increases if you are also taking other drugs that increase serotonin, so tell your doctor or pharmacist of all the drugs you take (see Drug Interactions section). Get medical help right away if you develop some of the following symptoms: fast heartbeat, hallucinations, loss of coordination, severe dizziness, severe nausea/vomiting/diarrhea, twitching muscles, unexplained fever, unusual agitation/restlessness.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before using rizatriptan, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood circulation problems (for example, in your legs, arms/hands, or stomach), certain types of headaches (hemiplegic or basilar migraine), heart problems (such as chest pain, irregular heartbeat, previous heart attack), liver disease, seizure, stroke or “mini-stroke” (transient ischemic attack).

Certain conditions can increase your risk for heart problems. Tell your doctor if you have any of these conditions, including: high blood pressure, high cholesterol, diabetes, family history of heart disease, overweight, smoker, postmenopausal (women), age more than 40 years (men).

This drug may make you dizzy or drowsy. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

The risk of heart disease, liver disease, and high blood pressure increases with age. Older adults may be more sensitive to the side effects of this drug, especially increased blood pressure and heart problems.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Do not take any MAO inhibitors (isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before treatment with this medication. Ask your doctor when to start or stop taking this medication.

The risk of serotonin syndrome/toxicity increases if you are also taking other drugs that increase serotonin. Examples include street drugs such as MDMA/”ecstasy,” St. John’s wort, certain antidepressants (including SSRIs such as fluoxetine/paroxetine, SNRIs such as duloxetine/venlafaxine), among others. The risk of serotonin syndrome/toxicity may be more likely when you start or increase the dose of these drugs.

If you also take any ergotamine medication (such as dihydroergotamine) or other “triptan” drugs (such as sumatriptan, zolmitriptan), you will need to separate your rizatriptan dose at least 24 hours apart from your dose of these other medications to lessen the chance of serious side effects.

Does Maxalt interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Do not share this medication with others.

Certain foods, beverages, or food additives (such as red wine, cheese, chocolate, monosodium glutamate) as well as lifestyle patterns such as irregular eating/sleeping habits or stress may bring on a migraine headache. Avoiding these “triggers” may help lessen migraine attacks. Consult your doctor for more details.

Lab and/or medical tests (such as blood pressure) may be done while you are taking this medication. Keep all medical and lab appointments. Consult your doctor for more details.

Not applicable. (See How to Use section.

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Images

Maxalt 10 mg tablet

Color: pale pinkShape: oblongImprint: MAXALT MRK 267

This medicine is a pale pink, oblong, tablet imprinted with “MAXALT” and “MRK 267”.

Maxalt 10 mg tablet

Color: pale pinkShape: oblongImprint: MAXALT MRK 267

This medicine is a pale pink, oblong, tablet imprinted with “MAXALT” and “MRK 267”.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Maxalt – Uses, Side Effects, Interactions

How does this medication work? What will it do for me?

Rizatriptan belongs to a class of medications known as 5-hydroxytryptamine agonists (also called triptans). It is used to treat migraine headaches with or without aura (warning signs that occur prior to the onset of a migraine headache). The pain of migraine headaches is thought to be caused by dilated blood vessels inside the head. Rizatriptan relieves migraine headaches by constricting these blood vessels.

Rizatriptan is most effective if taken at the first sign of a migraine headache. It is not recommended for other types of headaches or for headache prevention. Relief from the pain associated with migraine may occur as quickly as within 30 minutes, with maximum pain relief occurring about 2 hours after taking the medication. Rizatriptan should not be taken if you haven’t been diagnosed with having migraine headaches.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor.  Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

What form(s) does this medication come in?

10 mg
Each pale-pink, capsule-shaped, compressed tablet, embossed with the code “MSD 267” on one side and “MAXALT” on the other, contains 10 mg of rizatriptan (corresponding to 14.53 mg of the benzoate salt). Nonmedicinal ingredients: ferric oxide (red), lactose monohydrate, magnesium stearate, microcrystalline cellulose, and pregelatinized starch.

How should I use this medication?

The recommended adult starting dose of rizatriptan is 5 mg. In some cases, a starting dose of 10 mg may be used. The dose should be taken at the first sign of migraine headache pain. If the migraine headache comes back after being relieved, another dose (5 mg to 10 mg) may be taken no sooner than 2 hours after the first dose was taken.

The maximum recommended single dose is 10 mg. No more than 20 mg of rizatriptan should be taken in any 24-hour period. If your headache pain is different from your usual migraines, call your doctor and do not take rizatriptan. Rizatriptan is not to be used for headache prevention.

It is important to take this medication exactly as prescribed by your doctor.

For the wafer form of rizatriptan, it is not necessary to take the wafer with water. The wafer is packaged in a blister with an outer aluminum pouch. Do not remove the wafer from the package until you are ready to use it. When you are ready, peel open the blister pack with dry hands and place the wafer on your tongue. Allow the wafer to dissolve on your tongue, and swallow.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

Store this medication at room temperature, protect it from moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Who should NOT take this medication?

Do not take this medication if you:

• are allergic to rizatriptan or any ingredients of this medication
• have angina (chest pain), including Prinzmetal’s angina (coronary vasospasm)
• have blood vessel disease (e.g., ischemic bowel disease, Raynaud’s syndrome)
• have certain types of migraine headaches (including hemiplegic, ophthalmoplegic, or basilar migraine)
• have had a heart attack
• have had a stroke or transient ischemic attack (TIA)
• have heart disease (e.g., atherosclerosis, heart valve disease, abnormal heart rhythms, congenital heart disease)
• have high blood pressure that is severe or not under control
• have severely reduced liver function
• have taken another 5-hydroxytryptamine agonist (i. e., almotriptan, eletriptan, frovatriptan, naratriptan, sumatriptan, zolmitriptan) in the previous 24 hours
• have taken any medications belonging to the class of medications known as MAO inhibitors (see “What other drugs could interact with this medication?” below) in the previous 2 weeks
• have taken an ergotamine-containing or ergot-type medication (such as dihydroergotamine, ergotamine, or methysergide) in the past 24 hours

What side effects are possible with this medication?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• diarrhea
• dizziness
• drowsiness
• dry mouth
• headache
• hot flashes
• nausea or vomiting
• shortness of breath
• changes in the way things taste
• unusual tiredness or muscle weakness

Although most of these side effects listed below don’t happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• muscle pain
• pain, pressure, or tightness in the chest, neck, throat, jaw, or arms that does not go away
• sensation of burning, warmth, heat, numbness, tightness, or tingling

Stop taking the medication and seek immediate medical attention if any of the following occur:

• heart attack (symptoms include pain, pressure, tightness, or heaviness in the chest, jaw, neck, or shoulder; sweating; or shortness of breath)
• increased or decreased heart rate
• irregular or fast heartbeat
• seizures
• severe allergic reaction (symptoms include swelling of the face or throat, hives, or difficulty breathing)
• stroke (symptoms include sudden numbness or weakness, especially on one side of the body; sudden confusion or problems with speech; sudden vision problems in one or both eyes; sudden dizziness or loss of coordination; sudden severe headache, especially if it seems different from your usual headaches)
• sudden or severe abdominal pain

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Are there any other precautions or warnings for this medication?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Allergic reactions: Rarely, severe allergic reactions to rizatriptan may occur. Because of the possibility of an allergic reaction, people who are allergic to any of the other medications in this class (5-hydroxytryptamine agonists, also called triptans) should not use rizatriptan.

Blood pressure: Rizatriptan may cause an increase in blood pressure. People with severe or uncontrolled high blood pressure should not take rizatriptan.

Drowsiness/reduced alertness: This medication may cause drowsiness or dizziness, which may impair your ability to operate a vehicle or engage in dangerous activities that require alertness.

Heart and blood vessel disease: This medication may cause narrowing of the blood vessels that supply the heart and brain. This can lead to chest pain (angina), heart attacks, heart rhythm problems, stroke, transient ischemic attack (TIA or “mini-stroke”), and other heart or blood vessel problems. For this reason, rizatriptan should not be used by people with heart or blood vessel disease.

If you have certain risk factors for heart disease (e.g., high blood pressure, high cholesterol, smoking, obesity, diabetes, family history of coronary artery disease, menopause, men over 40 years of age), tell your doctor.

Kidney function: You should be closely monitored by your doctor if you are on dialysis and using this medication.

Liver function: Rizatriptan should not be used by people with severely reduced liver function. If you have moderately reduced liver function, you should be closely monitored by your doctor while taking this medication.

Medication overuse headaches: As with other pain relief medications, overuse of rizatriptan may lead to medication overuse headaches, or “rebound headaches” where the headache returns as the medication wears off. Avoid taking more of this medication than is recommended by your doctor. If you experience more frequent headaches, contact your doctor as soon as possible.

Phenylketonuria: The rapidly-dissolving wafer form of this medication contains phenylalanine.

Seizures: There have been rare reports of seizures experienced by people taking this medication. Most of these people had a previous history of epilepsy or medical conditions that increase the risk of seizures. If you have a history of epilepsy or other conditions that increase the risk for seizure, you should be closely monitored by your doctor while you are taking this medication.

Serotonin syndrome: This medication may cause a rare but potentially life-threatening condition called serotonin syndrome, especially when used with other medications that increase serotonin levels (e.g., other triptans, fluoxetine, paroxetine, venlafaxine).

If you experience symptoms such as agitation, confusion, hallucinations, fast heart rate, fever, lack of coordination, increased body temperature, overactive reflexes, nausea, vomiting, and diarrhea, get immediate medical attention.

Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: It is not known if rizatriptan passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using this medication have not been established for children.

Seniors: The safety and effectiveness of rizatriptan have not been adequately studied in people over 65 years. Its use in this age group is not recommended.

What other drugs could interact with this medication?

There may be an interaction between rizatriptan and any of the following:

• bromocriptine
• ergotamine-containing or ergot-type medication if taken at the same time or within the previous 24 hours (e. g., dihydroergotamine or methysergide)
• fentanyl
• linezolid
• lithium
• meperidine
• methylene blue
• mirtazapine
• monoamine oxidase inhibitors if taken at the same time or within 14 days of taking rizatriptan (e.g., phenelzine, tranylcypromine, moclobemide)
• other 5-hydroxytryptamine agonists if taken at the same time or within the previous 24 hours (e.g., sumatriptan, naratriptan, zolmitriptan)
• propranolol
• serotonin/norepinephrine reuptake inhibitors (SNRI antidepressants; e.g., duloxetine, desvenlafaxine, venlafaxine)
• selective serotonin reuptake inhibitors (SSRI antidepressants; e.g., fluoxetine, fluvoxamine, paroxetine, sertraline, vortioxetine)
• tramadol
• trazodone
• tricyclic antidepressants (e.g., amitriptyline, doxepin, imipramine, nortriptyline)
• tryptophan
• vilazodone

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

All material copyright MediResource Inc. 1996 – 2023. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/drug/getdrug/Maxalt

Maxalt (Rizatriptan Benzoate) Side Effects, Warnings, Usage

• Generic Name: Rizatriptan Benzoate
• Brand Name: Maxalt

• Overview
• Consumer Information

9 0009 Professional Information

• Related Resources

Side Effects Center Maxalt

Pharmacy editor: Melissa Konrad Stöppler, MD

What is Maxalt?

Maxalt Tablets (rizatriptan) is a selective 5-hydroxytryptamine 1B/1D (5-HT1B/1D) receptor. an agonist is used to treat migraine headache. Maxalt is believed to work by constricting blood vessels around the brain and reducing levels of substances involved in the development of migraine pain. Maxalt only treats a headache that has already begun. Maxalt will not prevent headaches or reduce the number of attacks.

What are the side effects of Maxalt?

Side effects of Maxalt may include:

• mild headache (not migraine),
• dry mouth,
• nausea;
• feeling of pain or tightness in the jaw, neck or throat;
• pressure or heaviness in any part of the body;
• dizziness;
• drowsiness;0004
• redness (feeling of warmth, redness or tingling under the skin).

Dosage for Maxalt

The recommended starting dose of Maxalt is 5 mg or 10 mg for acute conditions. treatment of migraine in adults.

What drugs, substances or supplements do Maxalt interact with?

Maxalt may interact with other migraine medicines, propranolol, or antidepressants. Tell your doctor about all medications and supplements you are taking.

Maxalt during pregnancy and lactation

It is not known if this medicine is harmful to the unborn child. Before taking rizatriptan, tell your doctor if you are pregnant or plan to become pregnant during treatment. It is also not known whether rizatriptan passes into breast milk or if it could harm a nursing baby. Consult your doctor before breastfeeding.

More Information

Our Maxalt Side Effects Center provides a comprehensive overview of available drug information about the potential side effects of this medication.

This is not a complete list of side effects and they may occur. Ask your doctor about side effects. You can report side effects to the FDA at 1-800-FDA-1088.

Consumer Information Maxalt

Get emergency medical help if you have signs of an allergic reaction : hives; labored breathing; swelling of the face, lips, tongue, or throat.

Stop using rizatriptan and call your doctor at once if you have:

• sudden and severe abdominal pain and bloody diarrhoea;
• sensation of coldness or numbness in the legs and arms;
• severe headache, blurred vision, pounding in the neck or ears;
• symptoms of heart attack – pain or pressure in the chest, pain extending to the jaw or shoulder, nausea, sweating;
• high levels of serotonin in the body – agitation, hallucinations, fever, sweating, trembling, palpitations, muscle stiffness, twitching, incoordination, nausea, vomiting, diarrhea; or
• signs of a stroke – sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, vision or balance problems.

Common side effects may include:

• dizziness, drowsiness, feeling tired; or
• pain or pressure in the throat or chest.

This is not a complete list of side effects and they may occur. Ask your doctor about side effects. You can report side effects to the FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Maxalt (Rizatriptan Benzoate)

Learn More ‘ Maxalt Professional Information

SIDE EFFECTS

The following adverse reactions are described in more detail elsewhere on the label:

900 09 Myocardial ischemia, myocardial infarction and Prinzmetal’s angina [cm. WARNINGS AND PRECAUTIONS ].
• Arrhythmias [see WARNINGS AND PRECAUTIONS ].
• Pain/tightness/pressure in the chest, throat, neck and/or jaw [see WARNINGS AND PRECAUTIONS ].
• Cerebrovascular events [see WARNINGS AND PRECAUTIONS ].
• Other vasospasm reactions [see WARNINGS AND PRECAUTIONS ].
• Drug overuse Headache [see WARNINGS AND PRECAUTIONS ].
• Serotonin syndrome [see WARNINGS AND PRECAUTIONS ].
• Increased blood pressure [see WARNINGS AND PRECAUTIONS ].

Clinical trial experience

Because clinical trials are conducted in a wide variety of settings, the frequency of adverse reactions observed in clinical trials of a medicinal product cannot be directly compared with the incidence in clinical trials of another drug and may not reflect rates observed in practice.

adults

Incidence in controlled clinical trials

Adverse reactions to MAXALT were evaluated in controlled clinical trials in which more than 3700 adult patients took single or multiple doses of MAXALT tablets. The most common adverse reactions during treatment with MAXALT (≥ 5% in any treatment group and more than in the placebo group) were asthenia/fatigue, drowsiness, sensation of pain/pressure, and dizziness. These adverse reactions appeared to be dose-dependent.

Table 1 lists adverse reactions (incidence ≥ 2% and higher than placebo) after a single dose of MAXALT in adults.

Table 1: Frequency (≥ 2% or more than placebo) of adverse reactions after a single dose of MAXALT tablets or placebo in adults

9 0175

9018 2 Drowsiness

	MAXALT 5 mg (N = 977)	MAXALT 10 mg (N = 1167)	Placebo (N = 627)
Paresthesia	3	4
Pain and other sensations of pressure	6	9	3
75	tightness / pressure and / or gravity		3	one
Neck / throat / jaw:
pain / tightness / pressure		two	one
Regional pain:
tightness/pressure and/or heaviness		two , location not specified	3	3
DRIVATION		13	8
DRUGE DRIEM	3	3	one
Nausea	4	6	4
Neurological	14	twenty	11
Dizziness	4	9	5
Headache		two
4	8	4
Other			90 177
Asthenia/fatigue	4	7	two

The incidence of adverse reactions in clinical trials did not increase with up to three doses within 24 hours. The frequency of adverse reactions also did not change with the simultaneous use of drugs usually taken to prevent migraine (including propranolol), oral contraceptives or analgesics. The incidence of adverse reactions did not depend on age or gender. There are insufficient data to assess the effect of race on the incidence of adverse reactions.

Other events observed with MAXALT in adults

The following section presents the frequency of less frequently reported adverse events that were not listed in other sections of the label. Because the reports include events observed in open studies, the role of MAXALT in their causation cannot be reliably determined. In addition, the variability associated with the reporting of adverse events, the terminology used to describe adverse events, limits the value of the quantitative estimates of frequency provided. The event rate is calculated as the number of patients who used MAXALT and reported an event divided by the total number of patients exposed to MAXALT (N = 3716). All registered events occurred with a frequency & ge; 1% or considered reasonably related to the use of the drug. Events are further classified into body system categories and listed in descending order of frequency using the following definitions: common adverse events are defined as those that occur in at least (>) 1/100 patients; infrequent side effects are observed in 1/100 – 1/1000 patients; and rare side effects occur in less than 1/1000 patients.

bupropion hcl xl 300 mg high

General: Infrequently there was swelling of the face. Rarely were syncope and edema/swelling.

Atypical sensations: Warm sensations were frequent.

Cardiovascular: Palpitations. Tachycardia, cold extremities and bradycardia have been observed infrequently.

Digestive: Diarrhea and vomiting were frequent. Infrequently observed dyspepsia, swelling of the tongue and bloating.

Musculoskeletal: Muscle weakness, stiffness, myalgia and muscle cramps/spasms were infrequent.

Neurological / Psychiatric: Hypoaesthesia, euphoria and tremor were frequent. Infrequent were dizziness, insomnia, confusion/disorientation, gait disturbance, memory impairment, and agitation.

Respiratory: Shortness of breath was frequent. Infrequently there was swelling of the pharynx.

Special Senses: Infrequently there were blurred vision and tinnitus. Rarely were swelling of the eyes.

Skin and epidermis: Frequent redness. Infrequently there were sweating, pruritus, rash and urticaria. Rarely was erythema, hot flashes.

The adverse reaction profile observed with MAXALT-MLT oral disintegrating tablets was similar to that observed with MAXALT tablets.

Pediatric patients aged 6 to 17 years

Incidence in controlled clinical trials in pediatric patients

Adverse reactions to MAXALT-MLT were evaluated in a controlled clinical trial for the treatment of acute migraine (Study 7), which included 1382 pediatric patients aged 6 to 17 years, of which 977 ( 72%) took at least one dose. investigational drug (MAXALT-MLT and/or placebo) [see Clinical Research ]. The frequency of adverse reactions in pediatric patients in acute phase clinical trials in patients treated with MAXALT was similar to the placebo group. The pattern of adverse reactions in pediatric patients is expected to be similar to that in adults.

Other events observed with MAXALT-MLT in pediatric patients

The following section presents the frequency of less commonly reported adverse events. Because the reports include events observed in open studies, the role of MAXALT-MLT in their causation cannot be reliably determined. In addition, the variability associated with the reporting of adverse events, the terminology used to describe adverse events, limits the value of the quantitative estimates of frequency provided.

The event rate is calculated as the number of pediatric patients aged 6 to 17 years who used MAXALT-MLT and reported an event divided by the total number of patients exposed to MAXALT-MLT (N = 1068). All registered events occurred with a frequency & ge; 1% or considered reasonably related to the use of the drug. Events are further classified within the systemic organ class and numbered in descending order of frequency using the following definitions: Common adverse events are those that occur in (>) 1/100 pediatric patients; infrequent side effects are observed in children from 1/100 to 1/1000; and rare side effects occur in less than 1/1000 patients.

General: Fatigue was common.

Benefits of fig leaves

Ear and labyrinth disorders: Uncommon – hypoacusis.

Gastrointestinal disorders: Abdominal discomfort was common.

From the side of the nervous system: Uncommon were impaired coordination, impaired attention and presyncope.

Psychiatric disorders: Hallucinations were infrequent.

Post-marketing experience

The following section lists potentially important adverse events that have occurred in clinical practice and have been spontaneously reported to various surveillance systems. Events listed include all but those that are already listed elsewhere on the label, or are too general to be informative. Because the reports refer to events reported spontaneously from worldwide post-marketing experience, the frequency of events and the role of MAXALT in their causes cannot be reliably determined.

Neurological / Psychiatric: Capture.

Generic: Allergic conditions including anaphylaxis/anaphylactoid reaction, angioedema, wheezing, and toxic epidermal necrolysis [see CONTRAINDICATIONS ].

Special feelings: Dysgeusia.

Read all FDA prescribing information for Maxalt (Rizatriptan Benzoate)

Read More’ Related Resources for Maxalt

Concomitant drugs

• Ajovy
• Allzital
• Ativan
• Axert
• Change
• Cataflam

9000 9 Elyxyb

• Emgality
• Ergomar
• Frova
• Imitrex
• Imitrex Nasal Spray
• Midrin
• Naprelan 9000 4
• Naratriptan
• Nurtek ODT

• Onzetra Xsail
• Orbivan
• Relpax
• Reyvou
• Reasonable
• Sumavel DozePro
• Tosymra
• Stories
• Trianal
• Ubr elvy
• Vyepti
• Zecuity
• Zolmitriptan tablets generic
• Zomig
• Zomig nasal spray

Read Reviews Maxalt Consumer Information

Maxalt patient information is provided by Cerner Multum, Inc. and Maxalt Consumer information is provided by First Databank, Inc., used under license and subject to their respective copyrights.

Memorial Sloan Kettering Cancer Center

Adult Medication

Share

This document, provided by Lexicomp ^® , contains all the information you need to know about this medicine, including indications, directions for use, side effects, and when your healthcare provider should be contacted.

Trade names: USA

Maxalt; Maxalt-MLT

Trade names: Canada

ACCEL-Rizatriptan ODT; ACT Rizatriptan; ACT Rizatriptan ODT [DSC]; AG-Rizatriptan ODT; APO-Rizatriptan; APO-Rizatriptan RPD [DSC]; Auro Rizatriptan; CCP-Rizatriptan ODT; DOM-Rizatriptan RDT; JAMP Rizatriptan; JAMP Rizatriptan IR [DSC]; JAMP Rizatriptan ODT; MAR Rizatriptan; MAR Rizatriptan ODT; maxalt; MaxaltRPD; MYLAN-Rizatriptan ODT; NAT-Rizatriptan ODT; NRA-Rizatriptan ODT; PMS-Rizatriptan RDT; SANDOZ Rizatriptan ODT; TEVA-Rizatriptan ODT; VAN-Rizatriptan ODT [DSC]; VAN Rizatriptan [DSC]

What is this drug used for?

• Used to treat migraine.

What should I tell my doctor BEFORE taking this drug?

• If you have an allergy to this drug, any of its ingredients, other drugs, foods or substances. Tell your doctor about your allergies and how they have manifested.
• If you have high blood pressure.
• If you have ever had any of these health conditions: chest pain or angina pectoris, arterial disease in the lower or upper extremities, myocardial infarction or other heart disease, circulatory problems in the heart, brain, intestines or kidneys, stroke or transient ischemic attack (TIA), some types of migraine, such as hemiplegic or basilar migraine, or abnormal heart rhythms, such as Wolff-Parkinson-White syndrome.
• If you are taking propranolol.
• If you have taken medications for depression or Parkinson’s disease in the past 14 days. These include isocarboxazid, phenelzine, tranylcypromine, selegiline, or rasagiline. An episode of very high blood pressure may occur.
• If you have taken the following drugs within the last 24 hours: almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, or zolmitriptan.
• If you have taken ergotamine, methysergide, dihydroergotamine or similar medicines within the last 24 hours.

This list of drugs and conditions that may interfere with this drug is not all inclusive.

Tell your doctor and pharmacist about all medicines you take (both prescription and over-the-counter, natural medicines and vitamins) and any health problems you have. You need to make sure that this drug is safe for your conditions and in combination with other drugs you are already taking. Do not start or stop taking any drug or change the dosage without your doctor’s advice.

What do I need to know or do while taking this drug?

• Tell all your health care workers that you are taking this drug. These are doctors, nurses, pharmacists and dentists.
• Avoid driving and other activities that require increased attention until you see how this drug affects you.
• High blood pressure has happened with this drug. Monitor your blood pressure as directed by your doctor.
• This drug is not intended to prevent or reduce the frequency of migraine headaches.
• If you have a headache that is not like your usual migraine headaches, talk with your doctor before taking this drug.
• Be careful if you have risk factors for heart disease (high blood pressure, high cholesterol, being overweight, high blood sugar or diabetes, cigarette smoking, male sex and age over 40, early heart disease in other family members , postmenopausal women). Consult your doctor.
• Taking more of this drug (higher doses, more frequent use) than prescribed by your doctor may make your headaches worse.
• If you have phenylketonuria, talk to your doctor. Some foods contain phenylalanine.
• A severe and sometimes deadly complication called serotonin syndrome can occur. This risk may be increased if certain other drugs are taken at the same time. Call your doctor right away if you experience agitation, balance problems, confusion, hallucinations, high fever, tachycardia or abnormal heart rhythms, flushing, muscle twitching or stiffness, seizures, tremors or tremors, excessive sweating, severe diarrhea, nausea or vomiting , a very severe headache.
• If you are 65 years of age or older, use this drug with caution. You may experience more side effects.
• Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding. The benefits and risks for you and your child will need to be discussed.

What side effects should I report to my doctor immediately?

WARNING. In rare cases, this drug can cause serious and sometimes deadly side effects in some patients. Call your doctor right away or get medical help if you have any of the following signs or symptoms that could be associated with serious side effects:

• Signs of an allergic reaction, such as rash, hives, itching, red and swollen skin with blisters or peeling, possibly accompanied by fever, wheezing or wheezing, tightness in the chest or throat, difficulty breathing, swallowing or speaking, unusual hoarseness, swelling in the mouth, face, lips, tongue or throat.
• Signs of high blood pressure, such as a very severe headache, or dizziness, or loss of consciousness, or blurred vision.
• Vision change.
• Loss of vision. May persist for a long time.
• Unusual sensations of burning, numbness, or tingling.
• Severe nausea or vomiting.
• Severe abdominal pain or diarrhea with blood in the stool.
• Feeling of heaviness or tension in the muscles of the legs.
• Chills.
• Rarely, very bad and sometimes life-threatening heart problems, such as a heart attack or irregular heartbeat, have happened within a few hours of taking this drug. Seek immediate medical attention if you experience a feeling of tightness, pain, pressure, or heaviness in your chest, throat, neck, or jaw, if you break out into a cold sweat, if you experience shortness of breath, rapid heartbeat, irregular heartbeat, or very severe dizziness or fainting .
• Very bad and sometimes deadly cerebrovascular problems, such as a stroke, have rarely happened with this drug. If you have weakness on 1 side of your body, difficulty speaking or thinking, balance problems, drooping on 1 side of your face, or visual disturbances, call your doctor right away.

What are some other side effects of this drug?

Any medicine can have side effects. However, for many people, side effects are either minor or non-existent. Talk to your doctor or get medical help if these or any other side effects bother you or don’t go away:

• Feeling dizzy, drowsy, tired or weak.
• Nausea.

This list of possible side effects is not exhaustive. If you have any questions about side effects, please contact your doctor. Talk to your doctor about side effects.

You can report side effects to the National Health Board.

You can report side effects to the FDA at 1-800-332-1088. You can also report side effects at https://www.fda.gov/medwatch.

What is the best way to take this drug?

Use this drug as directed by your doctor. Read all the information provided to you. Strictly follow all instructions.

All forms:

• Take this drug with or without food.
• Take as soon as possible after the onset of an attack.

Adults:

• If your headache does not go away after the first dose, talk to your doctor. If your headache returns, you may take 1 more dose as directed by your doctor. If you are taking a second dose, be sure to wait at least 2 hours after taking your first dose.

Children:

• If your child’s headache does not go away, or if it gets better but then the pain returns, or if the child only gets a little better, talk to your doctor before giving another dose.

Lozenge:

• Do not touch the preparation with wet hands.
• Some brand names of this drug are available in blister packs. If this drug is presented in a blister pack, the tablet should be removed from the package immediately before use. Peel back the foil covering the blister. Do not squeeze the tablet through the foil. This can lead to a violation of the integrity of the tablet.
• Put the tablet on your tongue and let it dissolve. It is not necessary to drink water. Do not swallow the tablet whole. Do not chew, break, or crush the tablet.

Film:

• Do not take this drug out of the package until you are ready to take it.
• Put the tablet on your tongue and let it dissolve. This will take about 2 minutes. It is not necessary to drink water. This drug can be swallowed with saliva.

What should I do if I miss a dose of a drug?

• This drug should be taken as needed. Do not take the drug more often than prescribed by your doctor.

How do I store and/or discard this drug?

• Store at room temperature in a dry place. Do not store in the bathroom.
• Keep all medicines in a safe place. Keep all medicines out of the reach of children and pets.
• Dispose of unused or expired drugs. Do not empty into a toilet or sewer unless instructed to do so. If you have any questions about disposing of medicines, ask your pharmacist. Drug disposal programs may be in place in your area.

General drug information

• If your health does not improve or even worsens, see your doctor.
• Do not give your medicine to anyone and do not take other people’s medicines.
• Some medicines may come with other patient information leaflets. If you have questions about this drug, talk with your doctor, nurse, pharmacist, or other health care professional.
• Some medicines may come with other patient information leaflets. Check with your pharmacist. If you have questions about this drug, talk with your doctor, nurse, pharmacist, or other health care professional.
• If you think you have overdosed, call a poison control center or get medical help right away. Be prepared to tell or show what drug you took, how much, and when it happened.

Consumer Use of Information and Limitation of Liability

This summary information includes a summary of the diagnosis, treatment, and/or drug product. It is not intended to be a comprehensive source of data and should be used as a tool to help the user understand and/or evaluate potential diagnostic and treatment options. It does NOT include all information about conditions, treatments, medications, side effects, or risks that may apply to a particular patient. It should not be considered medical advice or a substitute for medical advice, diagnosis or treatment provided by a physician based on a medical examination and assessment of the patient’s specific and unique circumstances. Patients should consult with their physician for full information about their health, medical issues, and treatment options, including any risks or benefits regarding the use of medications. This information is not a guarantee that a treatment or drug is safe, effective, or approved for a particular patient.