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What is mobic tablets used for: Mobic Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

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Common and Rare Side Effects for Mobic oral

COMMON side effects

If experienced, these tend to have a Severe expression i

Sorry, we have no data available. Please contact your doctor or pharmacist.

If experienced, these tend to have a Less Severe expression i

  • diarrhea
  • intense abdominal pain

INFREQUENT side effects

If experienced, these tend to have a Severe expression i

  • a skin rash
  • visible water retention

If experienced, these tend to have a Less Severe expression i

  • a common cold
  • indigestion
  • constipation
  • urinary tract infection
  • dizziness
  • flu-like symptoms
  • pain
  • headache
  • nausea
  • gas

RARE side effects

If experienced, these tend to have a Severe expression i

  • water retention
  • high levels of potassium in the blood
  • anemia
  • large purple or brown skin blotches
  • decreased blood platelets
  • very low levels of granulocytes, a type of white blood cell
  • low levels of white blood cells
  • high blood pressure
  • a heart attack
  • angina, a type of chest pain
  • a stroke
  • inflammation of the blood vessels
  • low blood pressure
  • throat irritation
  • asthma
  • bronchospasm
  • canker sores
  • a stomach ulcer
  • stomach or intestinal ulcer
  • inflammation of the large intestine
  • liver failure
  • damage to the liver and inflammation
  • bleeding of the stomach or intestines
  • a type of kidney inflammation called interstitial nephritis
  • damage to the kidneys
  • kidney failure
  • renal papillary necrosis
  • inflammation of the skin with blisters
  • erythema multiforme, a type of allergic skin reaction
  • a skin disorder with blistering and peeling skin called toxic epidermal necrolysis
  • a skin disorder with blistering and peeling skin called Stevens-Johnson syndrome
  • skin rash with sloughing
  • hives
  • puffy face from water retention
  • wheezing
  • trouble breathing
  • chest tightness
  • an inability to completely empty the bladder
  • abnormal liver function tests
  • a significant type of allergic reaction called anaphylaxis
  • a type of allergic reaction called angioedema
  • a rupture in the wall of the stomach or intestine
  • a yellowing of the eyes or skin from buildup of bilirubin called jaundice
  • pancreatitis
  • worsening of chronic heart failure
  • a type of significant allergic skin reaction called DRESS syndrome
  • fast heartbeat
  • an abnormally fast heartbeat

If experienced, these tend to have a Less Severe expression i

  • confusion
  • mood changes
  • a change in vision
  • ringing in the ears
  • dry mouth
  • inflammation of the esophagus
  • gastroesophageal reflux disease
  • black tarry stools
  • increased sensitivity of the skin to the sun
  • itching
  • hair loss
  • drowsiness
  • fainting
  • sensation of spinning or whirling
  • low energy
  • excessive sweating
  • muscle tremors
  • taste impairment
  • temporary redness of face and neck
  • weight gain
  • weight loss
  • cough
  • vomiting
  • burping
  • an increased need to urinate often
  • nervousness
  • a feeling of pins and needles on skin
  • a feeling of general discomfort called malaise
  • anxious feelings

What is meloxicam and what is it used for?

Living with arthritis and the associated pain and swelling can be difficult, but there are treatment options. Meloxicam is a prescription drug that helps relieve pain and inflammation from arthritis. Here we discuss what meloxicam is, why it’s prescribed, common dosage and side effects, and how it compares to other medications used for arthritis.

What is meloxicam?

Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) that is commonly used to treat arthritis. It helps treat pain, stiffness, inflammation, and swelling of the joints. Meloxicam is used to treat rheumatoid and osteoarthritis in adults, and juvenile rheumatoid arthritis in children who are at least 2 years old.

Meloxicam is a strong painkiller that must be prescribed by a doctor. It can come as a tablet, disintegrating tablet, capsule, or oral suspension liquid. Some popular brand names of meloxicam include Mobic, Vivlodex, and Meloxicam Comfort Pac. Boehringer Ingelheim Pharmaceuticals manufactures brand-name Mobic, and numerous other manufacturers make generic meloxicam.

What is meloxicam used for?

Meloxicam is used to treat the pain and inflammation that results from having rheumatoid arthritis, osteoarthritis, and juvenile rheumatoid arthritis. It works by blocking the enzymes cyclooxygenase 1 and 2, which lower levels of the inflammation-causing hormone, a prostaglandin. Meloxicam is sometimes used to treat a condition called ankylosing spondylitis, which is arthritis that affects the spine.

The main symptoms that meloxicam treats are pain, stiffness, swelling, and tenderness. Many people use ibuprofen to try and treat their arthritis symptoms as they arise, and even though both ibuprofen and meloxicam are nonsteroidal anti-inflammatory drugs, meloxicam is stronger. In one study, patients with osteoarthritis in the knee and hip showed significant improvement after 12 weeks in comparison to a placebo.

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Meloxicam dosages

Meloxicam is available as a tablet, disintegrating tablet, oral capsule, and as an oral suspension liquid. For osteoarthritis and rheumatoid arthritis, the standard dosage of meloxicam is 7. 5 mg taken once per day, with a maximum daily dosage of 15 mg. For children with juvenile rheumatoid arthritis, the standard dosage is 0.125 mg/kg per day, with a maximum dosage of 7.5 mg per day.

Meloxicam can take up to two weeks to start working in full effect. Some changes to pain, swelling, tenderness, or stiffness may be noticeable within 24 to 72 hours, but it might take longer to notice a large difference in pain levels.

“Meloxicam treats pain, swelling, and inflammation, especially associated with arthritis,” says Nonye Uddoh, Pharm.D., a clinical pharmacist with UnitedHealth Group. “It starts working within 30 minutes, but peaks in efficacy at four hours when taken by mouth. Its half life is 15-20 hours, meaning it takes 15 hours to eliminate half of it from your body.”

Dr. Uddoh also explains that meloxicam shouldn’t be used for people with asthma, aspirin sensitivity, known stomach disease, or by anyone with a medical history of ulcers or bleeding. Meloxicam shouldn’t be taken by anyone who has an allergy to nonsteroidal anti-inflammatory drugs. Anyone with a heart problem or heart disease should avoid taking this drug because it’s associated with a heightened risk of heart attacks. If you are about to have a coronary artery bypass graft (CABG), meloxicam shouldn’t be taken right before or after surgery.

If you are pregnant, planning to become pregnant, or breastfeeding you should avoid taking meloxicam. It’s possible that meloxicam could cause infertility or negatively affect your unborn baby. Research on whether or not meloxicam transfers to babies from their mother via breast milk is unclear.

Meloxicam shouldn’t be taken with the following drugs because it reacts negatively with them:

  • ACE-inhibitors
  • Aspirin
  • Diuretics
  • Lithium
  • Methotrexate
  • Cyclosporine

In the case of aspirin, taking it at the same time as meloxicam could result in an increased risk of ulcers. Keeping a list of all the medications you take, including any herbal products, can help doctors determine whether or not meloxicam is the right medication for you.

Taking ibuprofen and meloxicam at the same time shouldn’t be done without prior approval from a medical professional. Both medications are nonsteroidal anti-inflammatory drugs, and if they’re combined they can increase the risk of more serious side effects like stomach ulcers or bleeding.

Meloxicam is safe to take daily, and it’s typically longer-lasting than other over-the-counter medications like ibuprofen. Meloxicam is non-addictive and is easy to stop taking if wanted or required. Sometimes, serious side effects such as allergic reaction, nausea, or vomiting may occur. You should stop taking meloxicam immediately and seek medical advice if you experience any negative side effects.

What are the side effects of meloxicam?

As with any medication, there is always the potential for adverse effects. Here is a list of some of the common side effects associated with meloxicam:

  • Headache
  • Blurred vision
  • Dizziness
  • Diarrhea
  • Constipation
  • Stomach pain, nausea, or vomiting
  • Dark urine
  • Skin rash
  • Heartburn
  • Bleeding
  • Elevated potassium levels

Meloxicam has more serious side effects that are related to an increased risk of high blood pressure, stroke, and heart attacks. It may cause allergic reactions that can be life-threatening. An allergic reaction could cause a shortness of breath, sore throat, hives, or swelling of the lips, tongue, and face. If you believe you are having an allergic reaction, seek medical help immediately.

Meloxicam should not be taken if you are pregnant, planning to become pregnant, or breastfeeding. Anyone who has had ulcers, kidney or liver disease or problems, or stomach bleeding should not take this medication. It should be taken with extreme caution for people with fluid retention and heart failure. Older adults, those who are in poor health, and those who have been taking NSAIDs for a long time are more likely to experience these side effects.

Meloxicam is not addictive, but it interacts poorly with blood thinners and could lead to bleeding. Alcohol should be avoided as much as possible while taking meloxicam because it increases the risk of getting stomach ulcers.

More serious risk factors associated with taking meloxicam include chest pain, infrequent urination or not urinating at all, coughing up blood or vomit that looks like coffee grounds, and black, bloody, or tarry stools. You should stop taking meloxicam and call your doctor immediately if you experience any of these side effects. This list of side effects is not comprehensive. Ask a healthcare professional for more details regarding the possible side effects of meloxicam.

This medication guide is a great resource that lists FDA warnings, adverse reactions, drug interactions, and general drug information as it relates to meloxicam.

Are there alternatives to meloxicam?

There are multiple drug alternatives to meloxicam that function in a similar way. Any medication that’s classified as a nonsteroidal anti-inflammatory drug will be similar in nature to meloxicam. Some medications like Aleve and Tylenol are available over-the-counter. Speaking with a medical professional can help you determine which medication is best for treating your individual arthritis pain.

  • Aleve (naproxen): Aleve is long-lasting and treats mild to moderate pain, inflammation, and fever. It’s available over-the-counter or by prescription.
  • Cambia (diclofenac): Cambia helps with muscle aches and pain that are a result of inflammation. It often needs to be taken several times a day and is not for long-term use because of its side effects. See diclofenac vs. ibuprofen to learn more about diclofenac and how it compares to ibuprofen.
  • Celebrex (celecoxib): Celebrex treats arthritis pain but should not be used if you have a heart condition. It causes fewer stomach problems and has a lower risk of causing heart attacks than other NSAIDs. Check out meloxicam vs. Celebrex for more information on the differences between meloxicam and Celebrex. However, it has shown to increase risk for heart disease.
  • Feldene (piroxicam): Feldene can help with joint stiffness, pain, and swelling due to rheumatoid and osteoarthritis.
  • Lodine (etodolac): Lodine relieves pain from arthritis and other conditions. It may take up to two weeks to see therapeutic results, and Lodine is associated with some serious side effects like heart attacks and strokes. It’s important to speak with a medical professional if you are thinking of taking NSAIDs and have a heart condition.
  • Relafen (nabumetone): Relafen helps with pain and inflammation and is typically taken only once per day in comparison to other NSAIDs. It may take up to a week or more to feel a difference in pain levels if taking Relafen.
  • Tylenol Regular Strength (acetaminophen): Tylenol helps relieve pain and reduce fevers, but it doesn’t reduce swelling and inflammation. Tylenol is easier on the stomach and causes less bleeding than other pain medications. It’s available over-the-counter.

RELATED: Cambia details | Celebrex details | Feldene details | Lodine details | Nabumetone details

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Natural remedies for arthritis

Many natural and home remedies can help treat arthritis symptoms and may be an alternative to meloxicam for some people. Certain herbal supplements have anti-inflammatory properties, and natural treatments like massage therapy, acupuncture, or chiropractic adjustments can help manage pain symptoms. Here’s a list of some of the most popular natural and home remedies that people use to treat the stiffness, pain, aching, and swelling that come from having arthritis:

  • Anti-inflammatory diet. Foods that contain omega-3s, sulfur, antioxidants, and collagen will help lower inflammation and pain. Types of foods that contain these nutrients include wild-caught fish, walnuts, garlic, onions, bone broth, and fresh fruits and vegetables.
  • Staying active. Even though exercising might be more painful for people with arthritis, being active actually helps strengthen muscles that surround joints, which gives them more support. Exercising regularly lowers inflammation levels in the body. Stretching, walking, strength training, biking, and swimming are all activities that someone with arthritis could benefit from.
  • Ginger and turmeric. Even though the use of herbal supplements like ginger and turmeric aren’t approved by the FDA, many people still use them and benefit from their anti-inflammatory properties. Ginger acts as an anti-inflammatory for the body, and also as an analgesic that helps reduce pain. The most active ingredient in turmeric is curcumin, which is a powerful anti-inflammatory that can help with joint inflammation and swelling.
  • Getting chiropractic care. Chiropractic adjustments may help relieve pain that comes from having osteoarthritis. Treatment varies on a case-by-case basis, but most chiropractic manipulations are done on the neck, back, and spine. Many chiropractic offices offer massage therapy as well, which also helps with pain.
  • Using boswellia essential oil. Also known as frankincense oil, boswellia essential oil is known for its ability to reduce arthritis pain. It can be combined with a carrier oil and applied topically over painful areas several times per day.

A Safer Alternative to Opioid Painkillers?

Although the dangers of opioid painkillers are well-known and documented, there are few alternative options that provide effective relief from chronic or severe pain. For those who are in recovery from substance use disorder, managing pain without opioid drugs may sometimes be difficult. Meloxicam is one drug that has been considered as a possible alternative to opioids and it shows promise. However, meloxicam and other NSAIDs also come with their own set of risks.

What is Meloxicam?

Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) that is used to treat pain and inflammation.1 It is sold under the brand name Mobic, which is used to treat arthritis. It is recommended that the lowest possible effective dose is used for patients taking meloxicam, as higher doses can cause significant health problems. The average dose is 7.5 mg daily and Mobic is administered in tablet, liquid, or capsule form.

How Does Meloxicam Work?

Meloxicam works to reduce pain by decreasing the production of prostaglandins, which are chemicals that contribute to inflammation, especially within the joints of the body. Other NSAIDs like Ibuprofen (Motrin), Indomethacin (Indocin), and Nabumetone (Relafen) work the same way.

Is Meloxicam a Strong Painkiller?

Yes, meloxicam is a strong painkiller that is only legally available with a prescription. Although NSAIDs are available in an over-the-counter or prescription form, meloxicam is more potent than other over-the-counter NSAIDs that are used to treat pain. Examples of less potent NSAIDs include ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), and diclofenac gel.

Is Meloxicam Stronger than Ibuprofen?

Yes, meloxicam is a stronger drug than ibuprofen. Both drugs are available in prescription form but ibuprofen is also available in over-the-counter form. Although both ibuprofen and meloxicam are nonsteroidal anti-inflammatory drugs (NSAIDs), meloxicam is a long-acting drug that can relieve pain for up to 24 hours and it is not prescribed in combination with other drugs. Comparatively, ibuprofen is generally taken three to four times a day (although longer-lasting forms of the drug can be prescribed) and it is available in combination with other medications.2

Is Meloxicam Like Tramadol?

Meloxicam and tramadol are both used to treat pain, so they are similar but not the same. Meloxicam and tramadol belong to different classes of drugs. Meloxicam is an NSAID and tramadol is a narcotic painkiller. Both drugs may also interact with alcohol, antidepressants, heart medication, or blood pressure medication. Meloxicam and tramadol share some side effects, including nausea, drowsiness, stomach upset, dizziness, diarrhea, headache, nervousness, and skin rash.

How Long Does Meloxicam Stay in Your System?

The elimination half-life of meloxicam (or the duration of time it takes your body to metabolize and get rid of half of the drug in your system) is about 20 hours.3 However, this varies from person to person. Meloxicam can also be detected by a urine drug test for up to five days after the last dose.

What is Meloxicam Used For?

Meloxicam is approved by the FDA to treat pain and inflammation caused by arthritis.4 Other NSAIDs like meloxicam are used to treat mild to moderate pain and fever. Specifically, NSAIDs may be used to treat a variety of medical conditions and ailments such as:

  • Headaches
  • Arthritis
  • Menstrual cramps
  • Sports injuries
  • Ankylosing spondylitis (a form of arthritis that causes chronic inflammation of the spine)

NSAIDs are also found in many cold and allergy medications.

Is Meloxicam a Narcotic?

No, meloxicam is not a narcotic. It is classified as a nonsteroidal anti-inflammatory drug (NSAID). Unlike narcotics, these types of drugs work by reducing the production of certain hormones that cause pain and inflammation.

Is Meloxicam a Controlled Substance?

No, meloxicam is not a controlled substance in the U. S. However, there is still a risk that it will be misused and it can cause psychological addiction even though it won’t get you high.

Does Meloxicam Help with Back Pain?

Although meloxicam may help relieve back pain, the FDA has only approved it for treating symptoms of juvenile rheumatoid arthritis, osteoarthritis, and rheumatoid arthritis, such as inflammation, swelling, stiffness, and joint pain.5

What are the Side Effects of Meloxicam?

Although meloxicam is effective in relieving pain, swelling, and tenderness caused by arthritis conditions, it does have some side effects that users should be aware of. Common side effects of meloxicam include:

  • Stomachache
  • Nausea
  • Dizziness
  • Drowsiness
  • Blurred vision
  • Diarrhea
  • Increased blood pressure
  • Shortness of breath
  • Fluid retention/swelling
  • Liver damage/liver disease2

Some people are also highly allergic to NSAIDs, which can lead to serious reactions. Additionally, people who are at risk of heart disease may also face an increased risk of stroke or deadly heart attacks and people with kidney problems are at risk for kidney failure and should avoid taking meloxicam.4

Meloxicam vs. Opioids: Which is Safer?

According to the CDC, more than 191 million opioid prescriptions were dispensed to American patients in 2017 and between July 2016 and September 2017, emergency department visits for opioid overdoses rose 30 percent in all parts of the U.S.6,7 More than 130 people die every day from opioid-related overdoses and in 2017 alone, 2 million people misused prescription opioid drugs for the first time.6

Due to the clear dangers and risks of prescription opioid painkillers, medical experts and scientists are searching for alternatives that are just as effective for pain relief, without the risk for dependence and addiction. Unfortunately, this process isn’t as easy as it sounds. Every person has a different threshold for pain so certain drugs may work well for some, but not others. Additionally, some alternative drugs work to relieve pain, but they cause serious side effects.

Although opioid drugs like hydrocodone, morphine, fentanyl, oxycodone and others are touted as the most potent prescription painkillers available, one 2018 study published in JAMA found that they were no more effective than non-opioid drugs in treating moderate to severe chronic back pain or hip or knee osteoarthritis over a 12-month span.7

Since some scientific studies have shown meloxicam to be just as effective for certain types of pain relief, there is a possibility that it may be a better treatment method than opioid medication. Although a person could still abuse meloxicam and become psychologically dependent, the risk of dependence is less severe than that of opioids.

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Will Meloxicam Get You High?

While it is possible to abuse meloxicam by taking larger doses or taking it without a medical need for it, it will not produce a euphoric high as prescription opioids do. There is, however, a risk for overdose if a person takes too much meloxicam or takes it too quickly.4

Is Meloxicam Addictive?

Meloxicam is not considered physically addictive, although a person may become psychologically addicted to the pain relief it provides. Regardless, the FDA discourages doctors from prescribing meloxicam to people with a history of substance use disorder or to those who have previously abused prescription opioid painkillers.3

Meloxicam Abuse

Although meloxicam will not produce a euphoric high, some people still abuse it in the hopes of achieving a high that is similar to that of opioid painkillers. This is due to the common misconception that meloxicam is a narcotic when it is really an NSAID.

Unfortunately, if a person is not experiencing physical pain and they take meloxicam, they may suffer damage to the liver and kidneys. The medication may also cause their blood to thin. The risk of overdose is also much higher if a person abuses meloxicam with other NSAIDs like ibuprofen.10

The combination of meloxicam and alcohol is also highly dangerous and may result in jaundice, internal bleeding of the stomach, or liver failure.10 As a result, there is no benefit to abusing meloxicam recreationally.

Meloxicam comes with its own set of risks and side effects, but it may be a safer alternative to opioid painkillers without as much potential for abuse and addiction.

Treatment for Meloxicam Abuse

Abusing meloxicam recreationally might be a sign of a deeper problem, as the drug does not provide any euphoric side effects. A drug rehab program can provide life skills, peer support, and behavioral therapy to address co-occurring disorders and the root causes of your addiction, so you can learn how to live sober without relying on drugs to cope with life circumstances.

If you or a loved one is struggling with meloxicam abuse or is addicted to prescription medication, Nova Recovery Center can help. Call today to speak with a Nova admissions representative. We have immediate openings and accept several different health insurance providers.

References:

  1. https://www.medicinenet.com/meloxicam/article.htm#what_are_the_uses_for_meloxicam
  2. https://www.drugs.com/medical-answers/difference-between-meloxicam-ibuprofen-3504403/
  3. https://www.ncbi.nlm.nih.gov/pubmed/8630630
  4. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020938s022lbl.pdf
  5. https://www.mayoclinic.org/drugs-supplements/meloxicam-oral-route/side-effects/drg-20066928?p=1
  6. https://www.cdc.gov/drugoverdose/opioids/prescribed.html
  7. https://www.cdc.gov/vitalsigns/opioid-overdoses/index.html
  8. https://www.hhs.gov/opioids/about-the-epidemic/index.html
  9. https://jamanetwork.com/journals/jama/article-abstract/2673971
  10. http://www.safetymedical.net/meloxicam-abuse

Mobic | healthdirect

What it is used for

MOBIC tablets and capsules are indicated for the symptomatic treatment of osteoarthritis and rheumatoid arthritis.

How to take it

The way to take this medicine is: Oral.
This medicine is taken by mouth.

  • Store below 25 degrees Celsius
  • Protect from direct sunlight
  • Shelf lifetime is 3 Years.

You should seek medical advice in relation to medicines and use only as directed by a healthcare professional.

Always read the label. If symptoms persist see your healthcare professional.

Visual appearance

Pastel-yellow, round tablet in “SNAP-A-TAB” form, one face is convex with the Boehringer Ingelheim logo, the other face is concave and marked ’59D’ and has a broad break bar.

Images are the copyright of the Pharmacy Guild of Australia

Do I need a prescription?

What is the medicines and poisons schedule?

All medicines and poisons in Australia are categorised by how they are made available to the public. Medicines with a low safety risk are usually less tightly controlled than medicines with a higher safety risk. This system is called ‘scheduling’.

You can read more about the scheduling of medicines as well as the different scheduling categories on our Scheduling of medicines and poisons information page.

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This medicine is available from a pharmacist and requires a prescription. It is
Schedule 4 : Prescription Only Medicine.

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Acceptability

Criteria:

Inclusion criteria: – non-smoking men or women with a minimum age of 18 years (i.e.E. Non-smokers or non-smokers). tobacco smoker at least 90 days prior to the pre-test medical examination). – Body mass index (BMI = weight / height²) is greater than or equal to 18.5 kg / m² and less than 29.9 kg / m². – The presence of the subject for the entire period of study and the willingness to adhere to the protocol requirements, as evidenced by the signed informed consent form. – Normal physical examination results, 12-lead ECG and vital signs (blood pressure 100-140 / 60-90 mmHg)Art., pulse rate 50-99 beats / min, temperature from 35.8 ° C to 37.5 ° C). – Negative for drugs, nicotine, alcohol, hepatitis B surface antigen, hepatitis C and HIV, and for women – pregnancy (serum ß-CG). – There are no clinical laboratory values ​​outside the acceptable range defined by the BCR, unless the Principal Investigator determines they are not clinically relevant. – Female subjects who have been sterile surgically for at least six months or are postmenopausal.for at least one year, or who will avoid pregnancy before the study, during the study, and for up to one month after the end of the study. Exclusion criterion: – Known history of hypersensitivity to meloxicam (eg Mobic®) or related drugs such as any other nonsteroidal anti-inflammatory drugs (NSAIDs) such as acetylsalicylic acid (eg Excedrin®, Aspirin®), ibuprofen (eg Motrin®) , celecoxib (e.g. Celebrex®), Feldene®, Indocin®, Naprosyn®, Vioxx®, Toradol®, Clinoril®, Tolectin® or Lodin®.- Known history or presence of cardiac, pulmonary, gastrointestinal, endocrine, musculoskeletal, neurologic, hematologic or liver disease, unless otherwise determined to be clinically relevant to the principal investigator or appointed physician. – Any history or presence of peptic ulcer disease, gastrointestinal bleeding, or kidney disease. disease. – A history or presence of food allergies or any condition known to interfere with the absorption, distribution, metabolism or excretion of drugs.- Any clinically significant illness within the last four weeks prior to enrollment in the study. – The presence of any significant physical or internal abnormalities. – Any subject with a history of drug abuse. – Any mental or psychological illness (including depression) that is not considered clinically relevant to the principal investigator or designated physician. – Use of any prescription medication within 14 days prior to enrollment in this study. – Use of over-the-counter medications within seven days of enrollment (excluding spermicidal / barrier contraceptives).- Women: use of oral contraceptives or contraceptive implants (for example, Norplant®) within 30 days before the administration of the drug or depot injection of the progestogen drug (for example, Depo-Provera®) for one year before taking the drug. – Women: being pregnant or breastfeeding. – Women at risk of becoming pregnant must consent to the use of two medically acceptable methods of contraception throughout the study, including the washout period and within one month after completion of the study.barrier methods of contraception that can be used by the subject and / or partner include a diaphragm with a spermicide, an IUD, a foam condom, and a vaginal spermicide suppository. Complete abstinence can be used as a method of contraception. – Any subject from whom blood was drawn within 56 days prior to this study during any clinical study conducted at a facility other than BCR, or within the lockout period specified in a previous study conducted at BCR.- Participation in a clinical trial of an investigational drug within 30 days prior to that study. – Any subject who donated blood within the 56 days prior to this study. – Any subject who has participated as a plasma donor in a plasmapheresis program in the seven days prior to this study. – Any subject with a recent history of (less than one year) abuse of alcohol. – Significant or recent history of asthma (after 12 years) or family history of asthma or asthma sensitive to aspirin, severe bronchospasm, nasal polyps, or chronic sinusitis.- Intolerance to venipuncture. …

Floor:

All

Minimum age:

18 years old

Maximum age:

N / A

Healthy volunteers:

Accepts healthy volunteers

Since the beginning of its activity on the Ukrainian pharmaceutical market, the German pharmaceutical company “Boehringer Ingelheim” has been offering specialists high-quality drugs for use in various fields of medicine: rheumatology, pulmonology, gastroenterology, cardiology, etc.The company’s drugs have become brands and deservedly won the trust of consumers, since they fully meet their purpose – to improve the health of the population. Not stopping at what has been achieved, the Ukrainian representative office of Boehringer Ingelheim is constantly replenishing the portfolio of presented drugs, introducing new drugs (drugs) to the domestic pharmaceutical market. This autumn was no exception: the company delighted specialists working in the field of rheumatology by adding a dosage form of MOVALIS for intramuscular administration to the arsenal of doctors.

REFERENCES

1. Cacace L. (1972) Elevated serum CPK after drug injections. N. Engl. J. Med. 287: 309-10.

2. Vaccarino V., Sirtoni R., Bufalino L. (1989) Local and systemic tolerability of piroxicam after intramuscular administration in healthy volunteers.Curr. Ther. Res. 45: 1-13.

3. Stei P., Kruss B., Wiegleb J., Trach V. (1996) Local tissue tolerability of meloxicam, a new NSAID: indications for parenteral, dermal and mucosal administration. Br. J. Rheumatol. 35 (Suppl. 1): 44-50.

4. Narjes H., Turck D., Busch U., Heinzel G., Nehmiz G. (1996) Pharmaco-kinetics and tolerability of meloxicam after im administration. Br. J. Clin. Pharmacol. 41: 135-9.

5. Auvinet B., Ziller R., Appelboom T., Velicitat P.(1995) Comparison of the onset and Intensity of action of intramuscular meloxicam and oral meloxicam in patients with acute sciatica. Clin. Ther., 17: 1078–90.

6. Combe B., Velicitat P., Garzon N., Koneke N., Bluhmki E. Comparison of intramuscular and oral meloxicam in rheumatoid arthritis patients [This supplement].

7. Bosch H.-C., Sigmund R., Hettich M. (1997) Efficacy and tolerability of intramuscular and oral meloxicam in patients with acute lumbago: a comparison with intramuscular and oral piroxicam.Curr. Med. Res. Opin., 14: 29–38.

8. Ghozlan P.O.R., Bemhardt M., Velicitat P., Bluhmki E. (1996) Tolerability of multiple administration of intramuscular meloxicam: a comparison with intramuscular piroxicam in patients with rheumatoid arthritis and osteoarthritis. Br. J. Rheumatol. 35 (Suppl. 1): 51-5.

9. Baturone M., Euller-Ziegler L., Kneer W., Bluhmki E., Morene J. The intramuscular formulation of the COX-2 inhibitor meloxicam is effective and safe in osteoarthritis.Presented at 3rd APLAR congress, The Philippines, January 1998.

10. Dequeker J, Hawkey C, et al. (1998 Sep.) Improvement in gastrointestinal tolerability of the selective cyclooxygenase (COX) -2 inhibitor, meloxicam, compared with piroxicam: results of the Safety and Efficacy Large-scale Evaluation of COX-inhibiting Therapies (SELECT) trial in osteoarthritis. Br. J. Rheumatol., 37 (9): 946-951.

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