What is oxymetazoline hydrochloride: Oxymetazoline Nasal Spray: MedlinePlus Drug Information

28.01.201911.04.2021 by alexxlab

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Differences, similarities, and which is better for you

Nasal congestion occurs when blood vessels and surrounding tissues of the nasal passageway become overwhelmed by excess fluid. This creates a “stuffy” or plugged feeling in the nose, which may make it difficult to breathe. Nasal congestion may be accompanied by a runny nose, sneezing, cough, or headache.

Afrin (oxymetazoline) and Flonase (fluticasone propionate) are each nasal sprays that can provide a relief of symptoms related to nasal congestion. Though they are both nasal sprays, the mechanism by which they relieve congestion is very different.

What are the main differences between Afrin and Flonase?

The active ingredient in Afrin, oxymetazoline, is an alpha-adrenergic agonist. When used topically in nasal passages, it is a vasoconstrictor. This results in decreased fluid flow into the tissue and blood vessels of the nasal passageway, as well as an opening of the airway.

Afrin is effective in as little as 10 minutes, and its effects may last up to 12 hours. Although it is a very effective decongestant, there is evidence that it may cause rebound congestion when used for more than three days. Therefore, long-term use is not recommended. Afrin is available in various types of nasal spray solutions containing 0.05% oxymetazoline. There are 15 ml and 30 ml package sizes available. Afrin is available over-the-counter (OTC) without a prescription. Afrin is not indicated for children under 6 years of age, as well as adults.

Flonase, fluticasone propionate, is a corticosteroid. When corticosteroids are applied topically in the nasal passages, they exhibit antipruritic, anti-inflammatory, and vasoconstrictive properties. Corticosteroids induce peptides known as lipocortins, which then decrease the formation and release of inflammatory mediators. The effect of Flonase builds overtime after consistent use, and therefore it may take several days or weeks to realize the full benefit of Flonase. Flonase is available as a prescription and over-the-counter. As a prescription, it is a nasal spray bottle containing 120 sprays. The over-the-counter version is available as 60 spray or 120 spray bottles. Flonase can be used in children 4 years of age or older, as well as adults.

Main differences between Afrin and Flonase
Drug class	Alpha-adrenergic agonist	Corticosteroid
Brand/generic status	Brand and generic available	Brand and generic available
What is the generic name?	Oxymetazoline	Fluticasone propionate
What form(s) does the drug come in?	Nasal spray	Nasal spray
What is the standard dosage?	Two to three sprays in each nostril every 12 hours	One to two sprays in each nostril daily
How long is the typical treatment?	3 to 5 days	Several days to months
Who typically uses the medication?	Adults, Children 6 years of age or older	Adults, Children 4 years of age or older

Conditions treated by Afrin vs. Flonase

Afrin is indicated to treat nasal congestion. It is used off-label to induce vasoconstriction in nasal procedures. Afrin has no direct effect on inflammatory or allergic mediators, which may lead to sinus congestion.

Flonase is a prescription is indicated to treat allergic and nonallergic (perennial) rhinitis. The over-the-counter product is labeled to treat upper respiratory allergy symptoms related to hay fever or allergic rhinitis. These symptoms include stuffy nose, sneezing, runny nose, itchy nose, and itchy, watery eyes. It is the only over-the-counter nasal spray that carries an indication for all of these symptoms.

Sinus congestion	Yes	Yes
Vasoconstriction for nasal procedures	Off-label	No
Allergic rhinitis	No	Yes
Nonallergic rhinitis	No	Yes
Upper respiratory allergy symptoms	No	Yes

Is Afrin or Flonase more effective?

Afrin’s onset of action is 10 minutes, which provides patients with quick relief of nasal symptoms. Unfortunately, it is only recommended for use short term: three days or less. The full effect of Flonase may not be realized for a week or longer, but it is safe to be used long term. Flonase is also indicated to treat more than nasal congestion. It relieves multiple symptoms of the allergic response, including runny nose, sneezing, and itching eyes. Afrin has no effect on these allergic response factors.

One study looked at the concurrent use of oxymetazoline and fluticasone to determine if they could augment the response of each on congestion. It compared three treatment groups: placebo, oxymetazoline alone, and fluticasone with oxymetazoline. In this study, oxymetazoline was used for longer than the recommended duration of three days. Nasal air volume was significantly higher in the group using both oxymetazoline and fluticasone. It was also noted that rebound congestion was not present, suggesting that effect with oxymetazoline alone should be studied further. Your healthcare provider can help determine which product(s) are best for you.

Coverage and cost comparison of Afrin vs. Flonase

Afrin is typically not covered by insurance because it is not a prescription product. This is true for both Medicare and commercial plans. The retail cost for a 15 ml bottle could be as high as about $11. Your doctor can issue a prescription for Afrin, and with a SingleCare coupon, you could get the generic version for as low as $5. 11.

Flonase, or its generic, is typically covered by commercial and Medicare drug plans. The retail price for Flonase in a bottle containing 120 sprays can be as much as $28 but with a coupon, patients could pay as little as $11-$12 with a prescription.

Typically covered by insurance?	No	Yes
Typically covered by Medicare?	No	Yes
Standard dosage	15 ml bottle	16 g bottle
Typical Medicare copay	n/a	Varies, but typically less than $10
SingleCare cost	$5-$14	$11-$32

Common side effects of Afrin vs. Flonase

Afrin is known to cause a temporary, local irritation to the nasal mucosa, and this can induce sneezing. This should pass within a few minutes of administration. If Afrin is used for more than three days, patients may experience rebound congestion. This phenomenon, also known as rhinitis medicamentosa, is believed to be caused when the vasoconstriction induced by Afrin cuts off blood supply to the local tissues. This leads to swelling and inflammation. The sensation of the rebound congestion is said to feel worse than the original congestion Afrin was treating.

Flonase has a relatively high incidence of headaches with as much as 16% of patients experiencing headache after Flonase administration. Another very common side effect is nose bleeds or epistaxis.

Both Afrin and Flonase can cause local irritation of the nasal mucosa.

The following chart is not intended to be a complete list of all possible side effects. Please consult your doctor or pharmacist for a list of all possible side effects.

Side effect	Applicable?	Frequency	Applicable?	Frequency
Headache	No	n/a	Yes	4%-16%
Dizziness	No	n/a	Yes	1%-3%
Nausea/ Vomiting	No	n/a	Yes	3%-5%
Local irritation	Yes	Not defined	Yes	4%-6%
Increased intraocular pressure	No	n/a	Yes	1%-3%
Epistaxis	No	n/a	Yes	6%-12%
Nasal mucosal ulcer	No	n/a	Yes	3%-8%
Nasopharyngitis	No	n/a	Yes	8%
Acute sinusitis	No	n/a	Yes	5%
Blood in nasal mucosa	No	n/a	Yes	1%-3%
Dry nose	Yes	Not defined	Yes	1%-3%
Rebound nasal congestion	Yes	Not defined	No	n/a
Sore throat	No	n/a	Yes	1%-3%

Source: Afrin (DailyMed) Flonase (DailyMed).

Drug interactions of Afrin and Flonase

Although both Afrin and Flonase have primarily a local effect where they are applied topically in the nose, there are some other medications that may interact with them.

Ergot derivatives are a class of medications that may be used to treat migraines. Migranal is a nasal spray ergot derivative that works by causing marked vasoconstriction. The concurrent use of Afrin, which also causes vasoconstriction, would result in an extreme amount of vasoconstriction. This combination should be avoided.

Esketamine is an antidepressant nasal product administered once or twice weekly. Both Afrin and Flonase may decrease the effects of esketamine. If a nasal decongestant is necessary on an esketamine dosing day, the nasal decongestant should be administered at least one hour prior to esketamine.

The following table is not intended to be a complete list of possible drug interactions. Please consult your medical professional for a complete list.

Atomoxetine	Norepinephrine reuptake inhibitor	Yes	No
Cannabidiol Cannabis	Cannabinoids	Yes	No
Desmopressin	Vasopressin analog	No	Yes
Dihydroergotamine Ergotamine	Ergot derivatives	Yes	No
Esketamine	NMDA receptor antagonist	Yes	Yes
Fentanyl (nasal serum)	Opioid	Yes	No
Linezolid Tedizolid	Antibiotics	Yes	No
Amitriptyline Nortriptyline Doxepin	Tricyclic antidepressants	Yes	No

Warnings of Afrin vs. Flonase

Afrin is only intended to be used in a dosing increment of every 12 hours for not more than three days. Use of this product for any longer than recommended may result in extreme rebound congestion. Afrin may cause temporary discomfort such as stinging, itching, or burning in the nasal passage.

Flonase could slow healing after a nasal procedure or surgery and should not be used until approved by your doctor. If you take systemic steroids or immunosuppressant drugs, such as HIV drugs, talk to your doctor or pharmacist before using Flonase. Stinging or sneezing may occur immediately after administration. If your symptoms do not improve after seven days of use of Flonase, consult your physician.

Nasal spray containers are intended to be used by a single person. Sharing a nasal spray container may result in infection. Nasal sprays should not be sprayed in the eyes or mouth.

Frequently asked questions about Afrin vs. Flonase

What is Afrin?

Afrin is an over-the-counter nasal spray decongestant. It contains oxymetazoline, which is an alpha-adrenergic agonist that causes local vasoconstriction. Afrin is fast-acting, but should not be used for more than three consecutive days.

What is Flonase?

Flonase is a corticosteroid nasal spray available both as a prescription and over-the-counter. It contains the active ingredient fluticasone, which decreases the production of inflammatory mediators in the nasal passageway. Flonase reaches its full effect after several days or weeks and is safe to use long term.

Are Afrin and Flonase the same?

While both Afrin and Flonase are both nasal sprays that relieve the symptoms of nasal congestion, they are not the same. Afrin is a local vasoconstrictor that limits fluid infiltration to the nasal passage. Flonase is a steroid that mediates the inflammatory response brought on by an allergic response.

Is Afrin or Flonase better?

Afrin provides a faster response to congestion with an onset of action within 10 minutes. It is not recommended for use longer than three days, however. Flonase is slower to relieve congestion symptoms but can be used safely long term. Flonase is effective against other allergy symptoms such as runny nose, sneezing, and itchy eyes.

Can I use Afrin or Flonase while pregnant?

There have been adverse fetal events associated with Afrin use in the first trimester of pregnancy. Although one-time use in late pregnancy has not been shown to be harmful, Afrin is not a preferred nasal decongestant in pregnancy. Flonase may be safe to use during pregnancy, however other decongestant or steroid sprays may have more safety data available. Consult your physician for the preferred nasal decongestant choice.

Can I use Afrin or Flonase with alcohol?

Afrin and Flonase may be safely administered in patients who consume alcohol.

Is Afrin a steroid nasal spray?

Afrin is not a steroid. It is an alpha-adrenergic agonist that works by inducing vasoconstriction in the nasal passage.

Is flonase an antihistamine or decongestant?

Flonase is not an antihistamine or direct decongestant. It helps to relieve the symptoms of nasal congestion by slowing the infiltration of inflammatory mediators released during the allergic response.

When should I take Flonase morning or night?

Flonase may be dosed in one of two ways. A patient can either administer one spray in each nostril in the morning and/or evening (up to four total sprays in a 24-hour period), or patients may administer two sprays in each nostril at the same time, morning or evening.

Oxymetazoline nasal spray

What is this medicine?

Oxymetazoline (OX ee me TAZ oh leen) is a nasal decongestant. This medicine is used to treat nasal congestion or a stuffy nose. This medicine will not treat an infection.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): 12 Hour Nasal, Afrin, Afrin Extra Moisturizing, Afrin Nasal Sinus, Afrin No Drip Severe Congestion, Dristan, Duration, Genasal, Mucinex Children’s Stuffy Nose, Mucinex Full Force, Mucinex Moisture Smart, Mucinex Sinus-Max, Mucinex Sinus-Max Sinus & Allergy, NASAL Decongestant, Nasal Relief, Neo-Synephrine 12-Hour, Neo-Synephrine Severe Sinus Congestion, Nostrilla Fast Relief, Sinex 12-Hour, Sudafed OM Sinus Cold Moisturizing, Sudafed OM Sinus Congestion Moisturizing, Vicks Qlearquil Decongestant, Vicks Sinex, Vicks Sinex Severe, Vicks Sinus Daytime, Zicam Extreme Congestion Relief, Zicam Intense Sinus

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

diabetes
glaucoma
heart disease
high or low blood pressure
history of stroke
Raynaud’s phenomenon
scleroderma
Sjogren’s syndrome
thromboangiitis obliterans
thyroid disease
trouble urinating due to an enlarged prostate gland
an unusual or allergic reaction to oxymetazoline, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
breast-feeding

How should I use this medicine?

This medicine is for use in the nose. Do not take by mouth. Follow the directions on the package label. Shake well before using. Use your medicine at regular intervals or as directed by your health care provider. Do not use it more often than directed. Do not use for more than 3 days in a row without advice. Make sure that you are using your nasal spray correctly. Ask your doctor or health care provider if you have any questions.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 6 years for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.

What may interact with this medicine?

The medicine may interaction with the following medications:

MAOIs like isocarboxazid, phenelzine, rasagiline, selegiline, and tranylcypromine
medicines to treat blood pressure and heart disease like ace-inhibitors, beta-blockers, calcium-channel blockers, digoxin, and diuretics
medicines to treat enlarged prostate like alfuzosin, doxazosin, prazosin, and terazosin
nafarelin

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Tell your doctor or health care professional if your symptoms do not start to get better or if they get worse.

To prevent the spread of infection, do not share bottle with anyone else.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

burning, stinging, or irritation in the nose right after use
increased nasal discharge
sneezing

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medicine after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Oxymetazoline Hydrochloride in Combination With Nasal Glucocorticosteroid for Perennial Allergic and Non-allergic Rhinitis in Subjects With Persistent Nasal Congestion – Full Text View

Nasal glucocorticosteroids (GCS) are considered first-line therapy for both allergic and non-allergic rhinitis.1-3 Nasal congestion can persist despite maximum treatment with intranasal GCS. No other drugs are superior to intranasal GCS in relieving nasal congestion. For example, antihistamines are not effective in relieving congestion.1 Oral decongestants are somewhat beneficial in relieving nasal congestion but can elevate blood pressure, cause restlessness, and cause urinary retention. Oxymetazoline, however, is a potent decongestant and the addition of it to a nasal GCS should add a considerable decongestant benefit. It may also be beneficial in patients with persistent nighttime congestion despite maximum dosages of nasal GCS.

Oxymetazoline is currently recommended for three days use because of the proposed risk of rhinitis medicamentosa,4 which is increased nasal congestion caused by prolonged use of nasal decongestant sprays.5-8 The term RM was coined early in the twentieth century after several case reports described patients developing rebound congestion after using first generation intranasal decongestants such as privine hydrochloride and ephedrine for prolonged periods6,7. The histopathology and mechanism of RM has been based on animal models which may not be pertinent to humans.9-13 Studies using oxymetazoline, a newer intranasal decongestant, in individuals without rhinitis have shown conflicting evidence for the development of RM.14-16 For example, normal individuals without rhinitis using oxymetazoline three times daily for four weeks did not develop RM.17 Also, it is unknown the frequency of administration and dosage of oxymetazoline it takes to induce RM or whether RM is just a return to a patient’s baseline nasal congestion as present before beginning oxymetazoline. It is also unknown whether RM is more likely or only occurs with older vasoconstrictors such as privine hydrochloride and ephedrine rather than oxymetazoline.

Nasal GCS reduce the amount of rebound congestion in patients with perennial allergic rhinitis who have reportedly developed RM.18 Nasal GCS decrease nasal mucosa edema, recruitment of neutrophils and mononuclear cells, cytokine production, and late-phase nasal mediators.19-21 They may offer a protective benefit from the risk of developing RM. Oxymetazoline may also decrease inferior turbinate hypertrophy thereby permitting better adsorption of the nasal GCS.

Hypothesis

The addition of oxymetazoline to a nasal GCS for fourteen days will decrease the amount of congestion in subjects with allergic or non-allergic rhinitis with persistent congestion despite maximum recommended dosages of a nasal GCS. It is also hypothesized that nasal GCS protect against the development of RM secondary to oxymetazoline.

Oxymetazoline Hydrochloride Nasal Spray – 1oz — Butt Drugs

Compare to Afrin active ingredient

Indications

Temporarily relieves nasal congestion due to: Common cold; hay fever; upper respiratory allergies; temporarily relieves sinus congestion and pressure; shrinks swollen nasal membranes so you can breathe more freely. 12 hour relief. Fast, powerful congestion. Gluten free.

Directions

Adults and children 6 to under 12 years of age (with adult supervision): 2 or 3 sprays in each nostril not more often than every 10 to 12 hours. Do not exceed 2 doses in any 24-hour period. Children under 6 years of age: ask a doctor. To Use: Push firmly down on cap and turn counter clockwise. To spray, squeeze bottle quickly and firmly. Do not tilt head backward while spraying. Wipe nozzle clean after use. Secure cap after use. Store at 20-25 degrees C (68-77 degrees F). Retain carton for future reference on full labeling. Secure cap after use. Push, Turn. Do not use if printed neckband is broken or missing.

Active Ingredients

Oxymetazoline Hydrochloride 0.05%

Inactive Ingredients

Benzalkonium Chloride Solution; Benzyl Alcohol; Camphor; Dibasic Sodium Phosphate; Edetate Disodium; Eucalyptol; Menthol; Monobasic Sodium Phosphate; Polysorbate 80; Propylene Glycol; Purified Water

Warnings

Ask a doctor before use if you have: heart disease; high blood pressure; thyroid disease; diabetes; trouble urinating due to an enlarge prostate gland. When using this product: do not use more than directed; do not use for more than 3 days. Use only as directed. Frequent or prolonged use may cause nasal congestion to recur or worsen; temporary discomfort such as burning, stinging, sneezing or an increase in nasal discharge may occur; use of this container by more than one person may spread infection. Stop use and ask a doctor if symptoms persist. If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away (1-800-222-1222).

Oxymetazoline – MotherToBaby

This sheet talks about exposure to oxymetazoline pregnancy and while breastfeeding. This information should not take the place of medical care and advice from your healthcare provider.

What is oxymetazoline?

Oxymetazoline is a medication that is used in nasal sprays (sprayed into nostrils) and topical preparations (applied to skin). Oxymetazoline has been used to treat nasal congestion, eye inflammation, and skin redness. Oxymetazoline works by constricting blood vessels (makes the blood vessels smaller). Oxymetazoline can be found in prescription products and in many over the counter products. Some examples are: Afrin®, Dristan®, Nostrilla®, Rhofade®, and Vicks®.

I use oxymetazoline. Can it make it harder for me to get pregnant?

Studies have not been done in women to see if oxymetazoline could make it harder to get pregnant.

I just found out that I am pregnant. Should I stop taking oxymetazoline?

Talk with your healthcare providers before making any changes to this medication.

Does taking oxymetazoline increase the chance for miscarriage?

Miscarriage can occur in any pregnancy. Studies have not been done to see if oxymetazoline increases the chance for a miscarriage.

Does taking oxymetazoline in the first trimester increase the chance of birth defects?

In every pregnancy, a woman starts out with a 3-5% chance of having a baby with a birth defect. This is called her background risk. A small number of studies on oxymetazoline use have not found that oxymetazoline increases the chance of birth defects.

Could taking oxymetazoline in the second or third trimester cause other pregnancy complications?

Oxymetazoline did not affect uterine blood flow in 12 pregnancies when the healthy mother was given a one-time nasal spray dose.

Does taking oxymetazoline in pregnancy cause long-term problems in behavior or learning for the baby?

This has not been studied with the use of oxymetazoline.

Can I breastfeed while taking oxymetazoline?

Oxymetazoline has not been well studied for use while breastfeeding. However, since this is not an oral medication (it is sprayed into nose or rubbed onto skin) it is thought that very little of the medication could reach breastmilk. Be sure to talk to your healthcare provider about all of your breastfeeding questions.

If a man takes oxymetazoline, could it affect his fertility (ability to get partner pregnant) or increase the chance of birth defects?

This has not been studied. In general, exposures that fathers have are unlikely to increase risks to a pregnancy. For more information, please see the MotherToBaby fact sheet Paternal Exposures and Pregnancy at https://mothertobaby.org/fact-sheets/paternal-exposures-pregnancy/pdf/.

Selected References:

Aselton P, et al. 1985. First-trimester drug use and congenital disorders. Obstet Gynecol 65:451-455, 1985.
Baxi LV, et al. 1985. Fetal heart rate changes following maternal administration of a nasal decongestant. Am J Obstet Gynecol. 153:799-800.
Jick H, et al. 1981. First-trimester drug use and congenital disorders. JAMA 246:343-346.
Rayburn WF, et al. 1990. Uterine and fetal Doppler flow changes from a single dose of a long-acting intranasal decongestant. Obstet Gynecol. 76:180-2.
Yau W-P, et al. 2013. Use of decongestants during pregnancy and the risk of birth defects. Am J Epidemiol. 178(2):198-208.

View PDF Fact Sheet

Oxymetazoline Hydrochloride Combined With Mometasone Nasal Spray for Persistent Nasal Congestion (Pilot Study) | World Allergy Organization Journal

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Oxymetazoline Addiction and the Best Rehab Centers for Treatment

Trusted Content

Oxymetazoline is a nasal spray which helps people with congestion symptoms by clearing a person’s nasal passages and aiding in relief. However, with this effect comes side-effects of dependence and tolerance. When people use oxymetazoline for more than a few days their nasal passages no longer respond to the effects of it, but the spray is so effective it often fosters addiction.

How Does Oxymetazoline Work?

As the U.S. National Library of Medicine explains, “Oxymetazoline is in a class of medications called nasal decongestants. It works by narrowing the blood vessels in the nasal passages.” This reduces swelling and consequent congestion. However, oxymetazoline is only to be used for a short period of time. Directions suggest the use of no more than three to five days and only every 10 to 12 hours.

Unfortunately, after only a short time, the nasal spray will not produce the same effects. For people who have constant issues with congestion, experiencing relief can be a victory they want to experience again and again. But oxymetazoline and other nasal sprays like it can cause a “rebound effect.” This means that the nose may become accustomed to needing the spray in order to relieve the congestion, according to Everyday Health.

How Is Oxymetazoline Abused?

Because repeated use can cause a rebound effect, a person may begin abusing oxymetazoline to seek relief from congestion. When people use a medication for longer than prescribed, more frequently than directed, or for other reasons than intended, they are engaging in medication abuse. Oxymetazoline is an over-the-counter medication, is relatively inexpensive, easily obtained, and provides instant relief to troubling symptoms. These factors make it a prime target for abuse.

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Over time, a person may not be able to find relief from his or her symptoms, even with use of the spray. This condition is known as tolerance, and points to an addiction. Some other signs of a developing addiction are if a person’s congestion is no longer relieved with use of the spray, yet the person continues use of the medication, and if a person experiences withdrawal. Withdrawal symptoms can vary, but some include anxiety, headache, nausea, restlessness, or trouble sleeping.

What Are The Side Effects Of Oxymetazoline Abuse?

Use of oxymetazoline may produce a number of side effects, and prolonged abuse can enhance the severity of them. Some potential side effects include:

an increase in nasal discharge
an increase in sneezing
burning in the nasal passages
dizziness
dryness in the nose
headache
nausea
stinging in the nasal passages
trouble sleeping

Long-Term Effects Of Oxymetazoline Abuse

In addition to the development of addiction, those abusing oxymetazoline may experience adverse health conditions as well. Long-term congestion which does not respond to nasal decongestants is one potential outcome. Also, as WebMD states, “the longer you use a spray decongestant, the more likely you are to get the rebound phenomenon. It can lead to chronic sinusitis and other serious, long-term problems. ” Sinusitis is a blockage of the nasal passages and tissues that line the sinuses. Before any adverse health effects result from abuse, treatment for oxymetazoline addiction is the best course of action.

Who Is Affected By Oxymetazoline Abuse?

Oxymetazoline nasal spray is a medication easily bought at the local drugstore. Therefore, it is hard to measure exactly the percent of people who are abusing the medication. Little research has been done into the numbers of those affected by nasal spray abuse. However, one article on Medical News Today quotes a doctor who states that, of the 50 million or so Americans with chronic sinus problems, as many as one in four may be affected by nasal spray addiction.

What Are The Consequences Of Addiction?

Addiction can have staggering effects to a person’s mental, physical, and emotional health. It can also affect a person’s life—work performance, school involvement, and personal relationships. Addiction is a disease of the mind. While people may choose to use a substance or medication the first time, once their brain undergoes changes, they may be powerless to stop abuse. The National Institute on Drug Abuse (NIDA) explains, “Once addiction develops, these brain changes interfere with an individual’s ability to make voluntary decisions, leading to compulsive drug craving, seeking and use.”

What begins as seeking relief from some troublesome congestion issues may end with addiction. Addicted individuals may also develop chronic congestion or sinus issues that last even after they have completed treatment for the oxymetazoline addiction. Prolonged abuse can also cause severe nose bleeds and irritation of the blood vessels in the nasal passages.

What Are The Symptoms Of Addiction?

Symptoms of addiction vary from person to person. Abuse of medication is the addiction many people don’t see coming. Once addiction has started, the best recourse is treatment, as inpatient rehab centers offer the support needed to overcome addiction, and the best therapy methods for recovery.

Some common addiction symptoms include:

a feeling that a person needs to use the drug, whether daily or several times a day
experiencing strong urges to use the drug, or cravings for it
developing tolerance to the effects of the drug
keeping a steady supply of the drug, even if a person no longer needs it for medication
taking risks to obtain the drug: spending money you don’t have, getting the drug through illegal means, etc.
changes in how a person responds to obligation: poor work performance or falling behind in school
withdrawing from family or friends
lack of interest in activities or events which used to interest a person
inability to stop using the drug, even if a person really wants to
experiencing withdrawal symptoms when stopping use

Oxymetazoline Addiction Treatment

Inpatient rehab centers help addicted individuals stop use of a substance and prepare them to re-enter society. The best rehab centers, such as those we can connect you with at RehabCenter.net, will provide comprehensive treatment plans tailored to an individual’s specific needs. There are rehab centers that treat the separate needs of men and women. There are rehab centers that offer alternative therapy for those who need a different form of treatment. There are even rehab centers which offer faith-based healing.

Whatever treatment you choose, it may be best to complete it at a rehab facility. Completing treatment on your own is possible, but you won’t have the support that makes a margin of difference in your recovery. Inpatient rehab centers not only provide daily care, they are the (temporary) home of many others who are experiencing similar addiction issues. Further, completing treatment in an environment removed from the triggers of substance abuse can be the key to successful healing from addiction.

How To Reach Out For Help

There are millions who suffer daily from addiction, and many never get the treatment they need. If you or someone you know is struggling with addiction, don’t wait until it takes a toll on your health or your life. Contact us today at RehabCenter.net to speak with our experts and learn more about our rehab centers.

Article Sources

Active substance OXYMETAZOLIN (OXYMETAZOLINUM) | Compendium

Medicinal preparations containing the active substance OXYMETAZOLINE

decongestants and other topical preparations for diseases of the nasal cavity

NALONG

VALARTIN PHARMA

dosed nasal spray 0.05% bottle 10 g, No. 1

decongestants and other topical preparations for diseases of the nasal cavity

NAZIVIN

Dr.Reddy’s Laboratories Ltd

nasal drops 0.01% bottle 5 ml, No. 1

nasal drops 0.025% bottle 10 ml, No. 1

nasal drops 0.05% bottle 10 ml, No. 1

nasal spray 0.05% bottle 10 ml, No. 1

decongestants and other topical preparations for diseases of the nasal cavity

NAZIVIN SENSITIVE

Dr.Reddy’s Laboratories Ltd

nasal drops 0.01% bottle 5 ml, No. 1

nasal spray 0.025% bottle 10 ml, No. 1

nasal spray 0.05% bottle 10 ml, No. 1

decongestants and other topical preparations for diseases of the nasal cavity

NAZO-SPRAY

OZ GNTSLS

nasal spray 0.5 mg / ml container 15 ml, No. 1

decongestants and other topical preparations for diseases of the nasal cavity

NAZOL

Bayer

nasal spray 0.05% bottle 10 ml with a spray, No. 1

decongestants and other topical preparations for diseases of the nasal cavity

NAZOL ADVANCE

Bayer

nasal spray 0.05% bottle 10 ml with a spray, No. 1

decongestants and other topical preparations for diseases of the nasal cavity

NOXPRAY

Sperko Ukraine

nasal spray 0.05% container 10 ml, No. 1

nasal spray 0.05% container 15 ml, No. 1

nasal spray 0.05% container 20 ml, No. 1

NOXPRAY ASSET

nasal spray 0.5 mg / ml container 10 ml, No. 1

decongestants and other topical preparations for diseases of the nasal cavity

RINAZOLIN 0.25 / 0.5 mg drops and spray

Farmak

nasal drops 0.25 mg / ml 10 ml dispenser bottle, No. 1

nasal drops 0.5 mg / ml 10 ml dispenser bottle, No. 1

nasal spray 0.5 mg / ml bottle 15 ml in a pack, No. 1

decongestants and other topical preparations for diseases of the nasal cavity

AQUA SPRAY OXY

Red Star

dosed nasal spray 0.05% spray bottle 10 ml, No. 1

decongestants and other topical preparations for diseases of the nasal cavity

NAZO-SPRAY BABY

Health

nasal spray, solution 0.25 mg / ml glass bottle 15 ml with nasal attachment, No. 1

decongestants and other topical preparations for diseases of the nasal cavity

RINAZAL EXTRA

Darnitsa

nasal spray dosed 0.5 mg / ml bottle with dosing pump 10 ml, No. 1

decongestants and other topical preparations for diseases of the nasal cavity

α-adrenomimetic, vasoconstrictor for topical use in otorhinolaryngology and ophthalmology.

When injected into the nasal cavity, it narrows the arterioles of the nasal mucosa, which leads to a decrease in edema, hyperemia and exudation, facilitating nasal breathing. Reduces swelling of the mucous membrane around the opening of the Eustachian tube, improving drainage in Eustachitis and otitis media.

When instilled into the eyes, it has a vasoconstrictor effect on the superficial vessels of the conjunctiva.

The duration of action is usually 6 hours.

nasal drops, nasal aerosol – acute rhinitis, sinusitis, eustachitis, otitis media, to facilitate rhinoscopy or surgical procedures in the nasal cavity.

nasal drops, nasal aerosol – for adults and children from 6 years of age, 1-2 drops of 0.05% solution are injected into each nasal passage or 1-2 doses of spray (0.05% solution) 2 –3 times a day; children aged 1 to 6 years – 1-2 drops of 0.025% solution 2-3 times a day; for infants during the first 4 weeks of life, 1 drop of 0.01% solution is instilled into each nasal passage 2-3 times a day; from 5 weeks to the end of the 1st year of life – 1-2 drops of 0.01% solution in each nasal passage 2-3 times a day.Duration of application of 0.025% and 0.05% solution – no more than 4 weeks, and 0.01% solution – no more than 7 days.

atrophic rhinitis, angle-closure glaucoma, hypersensitivity to oxymetazoline.

possible irritation of the mucous membrane of the nose or eyes, burning sensation; in some cases, systemic side effects.

patients with diseases of the cardiovascular system, hypertension, hyperthyroidism are prescribed oxymetazoline with caution. It should be borne in mind the possibility of developing systemic side effects.

Oxymetazoline-acriquine spray naz. 0.05% 15ml n1

Short description

A vasoconstrictor for topical use in ENT practice

Pharmacological action

Adrenomimetic agent for topical use. Has a vasoconstrictor effect. With intranasal administration, the swelling of the mucous membrane of the upper respiratory tract decreases. When instilled into the conjunctival sac, it reduces the swelling of the conjunctiva.

Indication

Difficulty of nasal breathing with colds, inflammation of the sinuses, eustachitis, hay fever, allergic rhinitis, congestion and edema of the conjunctiva.

Way
application and dosage

Apply topically.

Side effects

From the respiratory system: possible transient dryness and burning of the nasal mucosa, dry mouth and throat, sneezing; with prolonged use, the appearance of reactive hyperemia of the mucous membrane, atrophy of the mucous membrane is possible. On the part of the cardiovascular system: palpitations; rarely – arterial hypertension. From the side of the central nervous system: increased excitability, dizziness, headache, sleep disturbances; with prolonged use – tachyphylaxis.From the digestive system: nausea. From the side of the organ of vision: with conjunctival administration, mydriasis, paresis of accommodation, irritation of the conjunctiva and surrounding tissues, eyelid retraction are possible.

Contraindications

Inflammation of the nasal mucosa without secretion, chronic heart failure, hyperthyroidism, diabetes mellitus, pregnancy, children under 6 years of age (for eye drops), hypersensitivity to oxymetazoline, atrophic rhinitis, lactation period, arrhythmias, severe atherosclerosis, arterial hypertension, CRF, angle-closure glaucoma.

Overdose of

Special
instructions

In the recommended dosage, without consulting a doctor, you can use it for no more than 3 days. Avoid getting the drug intended for intranasal administration in the eyes. Influence on the ability to drive vehicles and control mechanisms. The drug has an effect on vision, a decrease in the reaction rate is possible.

Interaction with other drugs

With the simultaneous appointment of MAO inhibitors and tricyclic antidepressants, an increase in blood pressure is possible.Oxymetazoline slows down the absorption of local anesthetic drugs, lengthens their effect. The co-administration of other vasoconstrictor drugs increases the risk of side effects.

Roster

1 ml oxymetazoline hydrochloride 0.5 mg. Excipients: benzalkonium chloride (50% solution) – 0.1 mg, citric acid monohydrate – 0.6093 mg, sodium citrate dihydrate – 3.823 mg, glycerol 85% – 24.348 mg, purified water – 978.6 mg.

Oxymetazoline – a reference book of medicines – HealthInfo

Synonym. Nazivin, Nazol, Nesopin, Oxymetazoline, Sanorinchik.

Composition and form of release. Synthetic preparation. The main active ingredient is oxymetazoline hydrochloride. Produced: 1) 0.01%, 0.025%, 0.05% nasal drops – in vials of 5 ml; 3) 0.05% nasal aerosol – 10, 15, 20, 30 ml in a bottle.

Medicinal properties. Reduces swelling of the mucous membranes of the nasal passages and paranasal sinuses. Facilitates nasal breathing. The duration of action is 10-12 hours.

Indications for use. Runny nose with ARVI and allergies, hay fever, swelling of the mucous membranes of the paranasal sinuses.

Application rules. Adults – 2-3 sprays; children from 6 to 12 years old – 1 injection in each nostril, or 1-2 drops of 0. 025-0.05% solution in each nasal passage 2-3 times a day. The interval between doses of the drug should be 10–12 hours.

Attention! The drug is not recommended to be taken for more than 3 days.

Side effects. Increased excitability, sleep disturbance, nausea, increased blood pressure, palpitations, dryness and burning sensation of the nasal mucosa, dry mouth and throat.

Contraindications. The drug should not be used for diabetes mellitus, arterial hypertension, cardiac arrhythmias, thyrotoxicosis, severe renal dysfunction, children under 1 year of age and with hypersensitivity to drug components.

Pregnancy and lactation. The drug is contraindicated during pregnancy and lactation.

Interaction with alcohol. No data available.

Special instructions. It is not recommended to simultaneously use nasol and other drugs administered intranasally (in the nasal passages).

If it is necessary to use it together with other medicines, you should first consult your doctor.

Storage conditions. Store in a dry, dark place at temperatures from 2 to 30 ° C. Shelf life – 2 years.

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Oxymetazoline: description, recipe, instruction

Oxymetazoline

Analogues (generics, synonyms)

Active ingredient

Oxymetazolinum

Pharmacological group

Alpha-adrenergic agonists, Anticongestants