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What is the drug norco: Norco Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing


Side effects, dosage, uses and more

  1. Acetaminophen-hydrocodone oral tablet is available as a generic drug and a brand-name drug. Brand names: Norco.
  2. Acetaminophen-hydrocodone comes as an oral tablet and an oral solution.
  3. Acetaminophen-hydrocodone oral tablet is used to treat moderate to severe pain that other treatments have not been able to relieve.

Other warnings

  • Severe allergic reaction warning: This medication may cause a severe, potentially life-threatening allergic reaction. The reaction can occur very quickly. Symptoms may include:
    • trouble breathing
    • swelling of your face, throat, and mouth
    • rash
    • itching
    • vomiting

If this occurs, stop taking this medication and call your doctor right away or get emergency medical help.

  • Adrenal gland problems warning: This medication may cause your adrenal glands to not work as well. Symptoms may include:
    • nausea
    • vomiting
    • loss of appetite
    • tiredness
    • weakness
    • dizziness
    • lightheadedness

If you have these symptoms, talk to your doctor. You may need to stop taking this medication or have some tests done.

Acetaminophen-hydrocodone is a prescription medication. As an opioid, it’s a controlled substance. It comes as an oral tablet and an oral solution.

Acetaminophen-hydrocodone oral tablet is available as the brand-name drug Norco. It’s also available in its generic form. Generic drugs usually cost less than brand-name drugs. In some cases, they may not be available in every strength or form as the brand-name version.

This medication is a combination of two drugs in a single form. It’s important to know about both of the drugs in the combination because each drug may affect you in a different way.

Why it’s used

Acetaminophen-hydrocodone oral tablet is used to treat moderate to severe pain that other treatments have not been able to relieve.

How it works

This medication is a combination of hydrocodone and acetaminophen. Hydrocodone is an opioid (narcotic), and acetaminophen is an analgesic (pain reliever). Both drugs are used to reduce pain.

These drugs work in your brain to block pain signals. They decrease your ability to feel pain.

Acetaminophen-hydrocodone oral tablet may make you feel sleepy, dizzy, or lightheaded. Avoid driving a car or using machinery until you know how your body reacts to this medication.

This drug can also cause other side effects.

More common side effects

The more common side effects that can occur with acetaminophen-hydrocodone include:

  • sleepiness or drowsiness
  • feeling dizzy or lightheaded
  • nausea
  • vomiting
  • constipation

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

  • Skin rash
  • Swelling of your face, throat, and mouth
  • Trouble breathing
  • Drug dependence
  • Liver problems, including liver failure. Symptoms may include:
    • yellowing of your skin and the whites of your eyes
    • pain in the upper right part of your stomach area
    • swelling of your stomach area
    • itchiness
    • confusion
    • feeling tired
    • lack of appetite

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.

Acetaminophen-hydrocodone oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Examples of drugs that can cause interactions with acetaminophen-hydrocodone are listed below.

Drugs that cause drowsiness

Taking certain drugs with acetaminophen-hydrocodone increases your risk of drowsiness, dizziness, tiredness, and reduced physical and mental function. If you need to use one of these drugs with acetaminophen-hydrocodone, the dosage of one or both drugs should be reduced.

Examples of these drugs include:

  • other opioids (narcotics)
  • antihistamines, which are used for allergies
  • antipsychotics, which are used for bipolar disorder, schizophrenia, or depression
  • benzodiazepines, which are used for anxiety

Drugs that increase serotonin

Taking this medication with drugs that increase the amount of a chemical called serotonin in your body can cause a serious problem. This problem, called serotonin syndrome, can be fatal. Tell your doctor if you are taking any of these medications:

  • some antidepressants (selective serotonin reuptake inhibitors [SSRIs], selective serotonin and norepinephrine reuptake inhibitors [SNRIs], tricyclic antidepressants [TCAs], monoamine oxidase inhibitors [MAOIs], mirtazapine, trazodone)
  • certain drugs for migraine (triptans)
  • certain drugs for nausea, such as ondansetron
  • tramadol, which is used for pain
  • linezolid, which is an antibiotic

Drugs that inhibit activity of certain enzymes in the liver

Taking this medication with drugs that can inhibit activity of certain liver enzymes can increase the amount of hydrocodone in your body and cause more side effects. You may have increased breathing problems or drowsiness. Examples of these drugs include:

  • erythromycin
  • ketoconazole
  • protease inhibitors used to treat HIV, such as ritonavir

Drugs that increase activity of certain enzymes in the liver

Taking this medication with drugs that can increase activity of certain liver enzymes can lower the amount of hydrocodone or acetaminophen in your body. You may need a higher dose of this medication to control your pain. Examples of these drugs include:

  • rifampin
  • carbamazepine
  • phenytoin

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

This drug comes with several warnings.

Allergy warning

This drug can cause a severe allergic reaction. Symptoms may include:

  • trouble breathing
  • swelling of your throat or tongue
  • hives
  • rash
  • itching

If you develop these symptoms, call 911 or go to the nearest emergency room.

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

Alcohol interaction warning

You shouldn’t drink alcohol while taking acetaminophen-hydrocodone. Drinking alcohol while taking this medication may cause:

  • slowed or stopped breathing
  • drowsiness
  • tiredness
  • mental cloudiness
  • physical and mental slowing

Combining alcohol with this drug also increases your risk for liver problems and liver damage.

Warnings for people with certain health conditions

For people with head injury: If you have a head injury, hydrocodone may cause increased pressure in your brain and cause breathing problems.

For people with stomach problems: Use caution taking this drug if you have intestinal obstruction, ulcerative colitis, or constipation. This medication may worsen your symptoms.

For people with severe kidney disease: This drug may build up in your body, which can cause trouble breathing and other side effects.

For people with lung disease: If you have lung disease, you might have trouble breathing if you take this medication.

For people with severe liver disease: If you have severe liver disease, your risk of liver failure is increased. Also, this drug may build up in your body, which can cause trouble breathing and other side effects.

For people with prostate enlargement: If you have an enlarged prostate, taking acetaminophen-hydrocodone may cause increased difficulty in urination.

For people with asthma: If you have severe or uncontrolled asthma, do not use this medication without talking to your doctor. You may have to take the first few doses in a monitored setting.

For pregnant women: This drug is a category C pregnancy drug. That means two things:

  1. Research in animals has shown adverse effects to the fetus when the mother takes the drug.
  2. There haven’t been enough studies done in humans to be certain how the drug might affect the fetus.

Tell your doctor if you’re pregnant or plan to become pregnant. Babies born to mothers who regularly take opioids such as hydrocodone may be born physically dependent on this drug. This can cause symptoms of withdrawal, or neonatal opioid withdrawal syndrome. Symptoms can include:

  • excessive crying
  • sneezing
  • shaking
  • rapid breathing
  • increased bowel movements
  • yawning
  • vomiting
  • fever

There’s also an increased chance that the baby may have trouble breathing if this medication is given to the mother shortly before giving birth.

For women who are breastfeeding: Acetaminophen is passed in small amounts in breast milk. Hydrocodone also passes into breast milk and may result in excessive tiredness and slowed breathing in a child who is breastfed.

Breastfeeding while taking this medication may come with risks. You and your doctor should decide whether you’ll take this medication or breastfeed.

For seniors: Older adults may have decreased kidney, liver, and heart function. If you’re a senior, your doctor may start you at a low dose of this medication.

All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on:

  • your age
  • the condition being treated
  • the severity of your condition
  • other medical conditions you have
  • how you react to the first dose

Forms and strengths

Generic: Acetaminophen-hydrocodone

  • Form: oral tablet
  • Strengths:
    • hydrocodone 5 mg/acetaminophen 300 mg
    • hydrocodone 7.5 mg/acetaminophen 300 mg
    • hydrocodone 10 mg/acetaminophen 300 mg
    • hydrocodone 2.5 mg/acetaminophen 325 mg
    • hydrocodone 5 mg/acetaminophen 325 mg
    • hydrocodone 7.5 mg/acetaminophen 325 mg
    • hydrocodone 10 mg/acetaminophen 325 mg

Brand: Norco

  • Form: oral tablet
  • Strengths:
    • 2. 5 mg hydrocodone/325 mg acetaminophen
    • 5 mg hydrocodone/325 mg acetaminophen
    • 7.5 mg hydrocodone/325 mg acetaminophen
    • 10 mg hydrocodone/325 mg acetaminophen

Dosage for moderate to severe pain

Adult dosage (ages 18 years and older and weighing at least 101 pounds [46 kg])

  • 5 mg or 2.5 mg hydrocodone / 300 mg or 325 mg acetaminophen: The typical dosage is 1–2 tablets taken every 4–6 hours as needed. The maximum dosage is 8 tablets per day.
  • 7.5 mg or 10 mg hydrocodone / 300 mg or 325 mg acetaminophen: The typical dosage is 1 tablet taken 4–6 hours as needed. The maximum dosage is 6 tablets per day.

Child dosage (ages 0–17 years)

  • Dosage for people younger than 18 years hasn’t been established.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always speak with your doctor or pharmacist about dosages that are right for you.

Acetaminophen-hydrocodone is used for short- or long-term treatment. It comes with risks if you don’t take it exactly as prescribed by your doctor.

If you stop taking the drug or don’t take it at all: Your pain will continue and might get worse.

If you miss doses or don’t take the drug on schedule: Your medication may not work as well or may stop working completely. For this drug to work well, a certain amount needs to be in your body at all times.

What to do if you miss a dose: If you’re taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it’s almost time for your next scheduled dose.

Don’t use extra medication to make up the missed dose. This could result in dangerous side effects.

If you take too much: If you take too much, you can overdose on this medication. You may experience:

  • nausea and vomiting
  • sweating
  • an overall feeling of fatigue
  • slowed or stopped breathing
  • slowed heart rate
  • very low blood pressure
  • possible coma
  • liver damage or failure

If you think you’ve taken too much of this drug, call your doctor or seek guidance from the American Association of Poison Control Centers at 1-800-222-1222 or through their online tool. But if your symptoms are severe, call 911 or go to the nearest emergency room right away.

How to tell if the drug is working: Your pain should decrease.

Keep these considerations in mind if your doctor prescribes acetaminophen-hydrocodone for you.


  • Take with food to lower your risk of upset stomach.
  • You can cut or crush the oral tablet.


  • Store this drug at temperatures ranging from 68°F to 77°F (20°C to 25°C).
  • Keep this drug in a container with a child-resistant closure.
  • Keep this drug away from light.
  • Keep this drug in a locked place and out of children’s reach.


A prescription for this medication is not refillable. You or your pharmacy will have to contact your doctor for a new prescription if you need this medication refilled.


When traveling with your medication:

  • Always carry your medication with you. When flying, never put it into a checked bag. Keep it in your carry-on bag.
  • Don’t worry about airport X-ray machines. They can’t hurt your medication.
  • You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled container with you.
  • Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.

Clinical monitoring

Your doctor may do certain tests to check whether you have severe liver or kidney disease. These tests will check your:

  • Kidney function. Your doctor may do kidney tests if you have kidney problems to make sure that this medication is safe for you and won’t cause breathing problems.
  • Liver function. Your doctor may do liver tests if you have liver problems to make sure that this medication is safe for you and won’t cause breathing problems.

Prior authorization

Most insurance companies do not require a prior authorization for this drug.

There are other drugs available to treat your condition. Some may be more suitable for you than others. Talk to your doctor about other drug options that may work for you.

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

Norco vs. Vicodin: What’s the Difference?

Last Updated: October 27, 2022

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Norco and Vicodin are both hydrocodone-containing opioid pain relievers. Norco and Vicodin generics are similar and can lead to hydrocodone addiction and liver damage.

Norco and Vicodin are both brand names for two prescription opioids used to treat moderate to severe pain. Both medications contain hydrocodone, a prescription-only opioid, and acetaminophen (APAP), an over-the-counter pain medication most commonly known as Tylenol. These medications are no longer available under the brand names Norco and Vicodin. They are now dispensed only as generic drugs. The generic versions of these opioid pain medications may be referred to as hydrocodone and acetaminophen, hydrocodone/acetaminophen or hydrocodone/APAP.

What Is Hydrocodone Used For?

Hydrocodone, a prescription opioid, is one of the ingredients found in several prescription pain medications. It’s an ingredient in various medications used to treat:

  • Severe acute pain (often after surgery or injury)
  • Severe, long-lasting pain
  • Cough

Hydrocodone is chemically similar to endorphins, our body’s natural painkillers released in response to pain or stress. It helps to relieve pain by changing how the brain and nervous system respond to pain. It also works to relieve cough by decreasing activity in the part of the brain that causes cough. 

Several prescription pain medications contain hydrocodone either as a single ingredient or in combination with other ingredients.  Examples of pain medications that contain hydrocodone include:

  • Hysingla
  • Lorcet**
  • Lortab**
  • Norco*
  • Vicodin*
  • Zohydro

*Brand name versions of this drug have been discontinued, while generic forms still exist.
**Brand name and generic versions of this drug have been discontinued.

What Is Norco?

Norco was a prescription-only opioid pain medication that contained hydrocodone and acetaminophen. It is now only available as a generic medication, but it may still be prescribed by an authorized practitioner as “Norco.” Norco was available in four different strengths:

  • Norco 2.5/325 tablet (hydrocodone 2.5 mg and acetaminophen 325 mg)
  • Norco 5/325 tablet (hydrocodone 5 mg and acetaminophen 325 mg)
  • Norco 7.5/325 tablet (hydrocodone 7.5 mg and acetaminophen 325 mg)
  • Norco 10/325 tablet (hydrocodone 10 mg and acetaminophen 325 mg)

What Does Norco Look Like?

Norco generic equivalents are available in tablet form. The shape and size of the tablet can vary depending on the manufacturer and strength. Some available generic products may look like this:

  • Norco 5/325 tablet (hydrocodone 5 mg and acetaminophen 325 mg)
    • White, oblong tablet with IP 109 imprinted on one side
    • White, round tablet with U01 imprinted on one side
    • White, oblong tablet with G035 imprinted on one side
    • Peach, oblong tablet with T257 imprinted on one side
  • Norco 7.5/325 tablet (hydrocodone 7.5 mg and acetaminophen 325 mg)
    • White, oblong tablet with M366 imprinted on one side
    • White, oblong tablet with U02 imprinted on one side
    • White, oblong tablet with G036 imprinted on one side
    • Pink, oblong tablet with E112 imprinted on one side
  • Norco 10/325 tablet (hydrocodone 10 mg and acetaminophen 325 mg)
    • Yellow, oblong tablet with 3601 imprinted on one side and V imprinted on one side
    • White, oblong tablet with IP110 imprinted on one side
    • White, oblong tablet with U03 imprinted on one side
    • White, oblong tablet with M367 imprinted on one side

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What Is Vicodin?

Vicodin was a prescription-only opioid pain medication available under the trade names Vicodin, Vicodin ES and Vicodin HP. All three formulations contained hydrocodone and acetaminophen, but each ingredient’s amount was slightly different. When it was initially approved, each version of Vicodin had different amounts of hydrocodone and acetaminophen. On January 13, 2011, the FDA requested that all drug manufacturers limit the amount of acetaminophen in prescription drug products to no more than 325 mg per dosage unit. This was because high levels of acetaminophen can cause hepatotoxicity, or liver damage.

In May 2012, the brand manufacturer of Vicodin discontinued all previous versions of Vicodin, Vicodin ES and Vicodin HP. They later introduced a reformulated version that contained only 300 mg of acetaminophen per tablet with varying amounts of hydrocodone. These reformulated versions have been discontinued under their brand name; however, they may still be prescribed as “Vicodin. ” They are currently available as a generic in the following strengths:

  • Vicodin 5/300 mg tablet (hydrocodone 5 mg and acetaminophen 300 mg)
  • Vicodin ES 7.5/300 mg tablet (hydrocodone 7.5 mg and acetaminophen 300 mg)
  • Vicodin HP 10/300 mg tablet (hydrocodone 10 mg and acetaminophen 300 mg)

What Does Vicodin Look Like?

Vicodin generic equivalents are available in tablet form. The shape and size of the tablet can vary depending on the manufacturer and strength. Some available generic products may look like this:

  • Vicodin 5/300 mg tablet (hydrocodone 5 mg and acetaminophen 300 mg)
    • White, oblong tablet with A41 imprinted on one side
    • White, oblong tablet with C114 imprinted on one side
    • White, oblong tablet with n351 imprinted on one side
  • Vicodin ES 7.5/300 mg tablet (hydrocodone 7.5 mg and acetaminophen 300 mg)
    • White, oblong tablet with A42 imprinted on one side
    • White, oblong tablet with n352 imprinted on one side
    • White, oblong tablet with C115 imprinted on one side
  • Vicodin HP 10/300 mg tablet (hydrocodone 10 mg and acetaminophen 300 mg)
    • White, oblong tablet with C116 imprinted on one side
    • White, oblong tablet with n353 imprinted on one side
    • White, oblong tablet with A43 imprinted on one side

Norco vs.

Vicodin: Side Effects

Because Norco and Vicodin both contained hydrocodone and acetaminophen, they have the same side effects, which include:

  • Constipation
  • Drowsiness
  • Lightheadedness
  • Anxiety
  • Mood changes (abnormally happy or sad)
  • Dry throat
  • Difficulty urinating
  • Rash
  • Itching
  • Narrowing of the pupils in the eyes
  • Clouded thinking

More severe side effects or signs of an overdose may include:

  • Slow or irregular breathing
  • Hallucinations (seeing things that are not there)
  • Confusion
  • Sweating or clammy skin
  • Rapid heartbeat
  • Shivering
  • Nausea, vomiting or diarrhea
  • Chest tightness
  • Unable to respond or wake up

Most of the noticeable side effects from combination medications containing hydrocodone and acetaminophen are from the ingredient hydrocodone. However, acetaminophen can cause hepatotoxicity, or liver failure. The signs of liver failure can be much harder to see than other side effects from these medications. Signs of hepatotoxicity include:

  • Fatigue (tiredness)
  • Nausea
  • Weakness
  • Abdominal pain
  • Itching
  • Jaundice (yellowing of the skin)

Norco vs. Vicodin: Strength and Effectiveness

Norco and Vicodin generics are very similar in strength and effectiveness. The main difference in strength is the amount of acetaminophen in each tablet. Vicodin generics contain 300 mg of acetaminophen, and Norco generics contain 325 mg of acetaminophen. This is important for those who have liver disease, consume acetaminophen while drinking or take other acetaminophen-containing medications. It is very important to be careful how much acetaminophen is taken in a 24-hour period. The maximum recommended amount of acetaminophen each day is 4000 mg. Consuming more than this amount can lead to liver damage.

Since both Vicodin and Norco generics are available with similar amounts of hydrocodone, their effectiveness is similar.  Studies have shown that hydrocodone and acetaminophen combination products effectively reduce pain. It is recommended to take the lowest dose possible for the shortest amount of time, depending on how severe the pain is and the person’s response to the pain medication. It is recommended that initial opioid prescriptions be limited to seven days or less so that pain levels can be reevaluated and treatment adjusted based on the person’s unique situation. Taking prescription opioid pain medications for an extended period of time may lead to drug tolerance, dependence or addiction.

Norco and Vicodin Addiction

In 2020, 9.5 million people aged 12 or older misused opioids (heroin and prescription pain relievers). Of these people, 9.3 million misused opioid prescription pain relievers. Opioid prescription pain relievers containing hydrocodone are included, such as Norco and Vicodin generics. Opioid misuse includes taking medication in a different way than prescribed, taking too much medication, taking someone else’s medication or taking medication to get high. Hydrocodone misuse can lead to hydrocodone addiction. 

Hydrocodone addiction involves using hydrocodone medications like Norco and Vicodin even when they cause significant distress or impairment in daily life. Anyone that takes hydrocodone-containing medications is at risk for addiction. Still, the risk of addiction increases with prolonged use or misuse of the medication. Signs of hydrocodone addiction include:

  • Continued use despite worsening physical or psychological health
  • Negative effects on relationships with friends, families and work
  • Participating less in activities once enjoyed
  • Difficulty completing duties at school or work
  • Excessive time spent to get opioids or recover from taking them
  • Taking more than intended
  • Cravings
  • Inability to decrease the amount used
  • Tolerance, where the person needs a higher dose to feel the same effects
  • Drug use even in a physically dangerous setting
  • Withdrawal symptoms when stopping 

Fortunately, treatment is available for those suffering from a hydrocodone addiction.  

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Hydrocodone Addiction Treatment

Hydrocodone addiction treatment can help people stop compulsive drug-seeking behavior and return to a healthy, productive life. Research has shown that individuals who remain in treatment over an extended period of time are able to stop using drugs, decrease their criminal activity and improve their mental health, relationships and work performance. 

It is important to explore all options available when choosing to begin hydrocodone addiction treatment. A medical professional can help determine the right treatment plan depending on the person’s needs. Several treatment programs are available, including:

  • Medical detox
  • Inpatient drug rehab
  • Partial hospitalization programs (PHP)
  • Intensive outpatient programs (IOP)
  • Outpatient drug rehab
  • Teletherapy or online drug rehab

At The Recovery Village Columbus, licensed addiction specialists will evaluate each person’s unique situation and develop a personalized treatment plan. With long-term healing in mind, patients are supported by their medical team through their hydrocodone detox to make it as safe and comfortable as possible. Following detox, therapists work with each patient to identify individual triggers and develop effective coping strategies to stay substance-free.

If you or someone you love is struggling with hydrocodone addiction in Ohio, The Recovery Village Columbus is here to help. Contact us today to learn more about hydrocodone addiction treatment programs that can help you on your road to recovery.

Norco (Hydrocodone Bitartrate & Acetaminophen): Uses, Dosage, Side Effects, Interactions, Warning

  • Generic Name: Hydrocodone Bitartrate & Acetaminophen
  • Brand Name: Norco
  • Drug Description
  • Indications and dosage
  • Side effects
  • Drug interactions
  • Warnings
  • Precautions
  • Overdose and contraindications
  • Clinical pharmacology
  • Medication guide

Product description

What is Norco and how is it used?

Norco is a prescription medicine used to treat symptoms of moderate to severe pain. Norco can be used alone or with other medicines.

Norco belongs to a class of drugs called analgesics, opioid combinations.

Norco is not known to be safe and effective in children under 2 years of age.

What are the possible side effects of Norco?

Norco may cause serious side effects, including:

  • noisy breathing,
  • sighing
  • shallow breathing,
  • lightheadedness,
  • nausea
  • ,
  • upper stomach pain,
  • fatigue,
  • loss of appetite,
  • dark urine,
  • clay-colored stools,
  • yellowing of the skin or eyes (jaundice), 9
  • vomiting,
  • loss of appetite,
  • dizziness,
  • increasing tiredness or weakness,
  • skin redness or rash that spreads with blisters or peeling,
  • agitation
  • 900 09 hallucinations,

  • high fever,
  • sweating
  • trembling
  • rapid heart rate,
  • muscle stiffness,
  • twitching
  • loss of coordination and
  • diarrhea

Get medical attention right away if you have any of the above symptoms .

The most common side effects of Norco include:

  • nausea,
  • vomiting,
  • abdominal pain, fatigue,
  • constipation and
  • headache

Tell your doctor if you have any side effects that bother you or that don’t go away.

These are not all possible side effects of Norco. For more information, contact your doctor or pharmacist.

Ask your doctor about side effects. You can report side effects to the FDA at 1-800-FDA-1088.


how much morphine to get high


Acetaminophen has been associated with cases of acute liver failure, sometimes leading to liver transplantation and death. Most cases of liver damage are associated with the use of acetaminophen at doses in excess of 4,000 milligrams per day and are often associated with more than one product containing acetaminophen.


NORCO (Hydrocodone bitartrate and acetaminophen) is supplied in tablet form for oral use.

Hydrocodone bitartrate is an opioid analgesic and antitussive and occurs as fine white crystals or crystalline powder. It is affected by light. The chemical name is 4,5α-epoxy-3-methoxy-17-methylmorphinan-6-one tartrate (1:1) hydrate (2:5). Has the following structural formula:

Acetaminophen, 4-hydroxyacetanilide, slightly bitter, white, odorless crystalline powder, non-opiate, non-salicylate analgesic and antipyretic. Has the following structural formula:

Each NORCO 5/325 tablet contains:

Hydrocodone bitartrate …… 5 mg
Acetaminophen ………….. 325 mg

In addition, each tablet contains the following inactive ingredients: colloidal silicon dioxide, croscarmellose sodium, crospovidone, microcrystalline cellulose, povidone, pregelatinized starch, stearic acid and sugar globules, which are composed of starch derived from corn, sucrose and FD&C Yellow #6.

Meets USP 1 dissolution test.

Indications and Dosage


NORCO is indicated for the relief of moderate to moderately severe pain.


Dosage should be adjusted according to the degree of pain and the patient’s response. However, it should be borne in mind that tolerance to hydrocodone may develop with continued use and that the frequency of adverse effects is dose dependent.

The usual adult dose is one or two tablets every four to six hours depending on the pain. The total daily dose should not exceed 8 tablets.


NORCO 5/325 Tablets (hydrocodone bitartrate and acetaminophen tablets, USP 5 mg/325 mg) contains 5 mg hydrocodone bitartrate and 325 mg acetaminophen. They come in white with orange dots, in capsule form, halved tablets, embossed with WATSON on one side and 913 on the other hand, in vials of 100 tablets, NDC 52544-913-01, in vials of 500 tablets, NDC 52544-913-05, and in hospital boxes of 100 tablets (25 tablets of 4 cards), NDC 52544-913-48.

Storage Location

Store at controlled room temperature 15-30°C (59-86°F).

Dispense in a tight, light-resistant container with a child-proof lid.

how to use nystatin oral suspension

Manufactured by: Mikart, Inc., Atlanta, GA 30318. Distributed by: Actavis Pharma, Inc., Parsippany, NJ 07054 USA. Revised: August 2014

Side effects


The most common adverse reactions are dizziness, dizziness, sedation, nausea and vomiting. These effects appear to be more pronounced in outpatients than in general patients, and some of these adverse reactions may be alleviated by lying down.

Other adverse reactions include:

Central nervous system

Drowsiness, confusion, lethargy, impaired mental and physical performance, anxiety, fear, dysphoria, mental dependence, mood changes.


Prolonged administration of NORCO may cause constipation.


Ureteral spasm, vesical sphincter spasm and urinary retention have been reported with opiates.

Respiratory depression

Hydrocodone bitartrate may cause dose-dependent respiratory depression by acting directly on the respiratory center of the brainstem (see OVERDOSE ).

Special Senses

Hearing impairment or irreversible loss has been reported predominantly in patients with chronic overdose.


Skin rash, pruritus.

The following adverse events can be considered as potential effects of paracetamol: allergic reactions, rash, thrombocytopenia, agranulocytosis. Possible effects of high dosage are listed in OVERDOSE section.

Drug abuse and dependence
Controlled substance

NORCO is classified as a Schedule II controlled substance.

Abuse and dependence

Mental dependence, physical dependence and tolerance may develop with repeated drug use; therefore, this product should be prescribed and administered with caution. However, psychic dependence is unlikely to develop with short-term use of NORCO tablets for pain relief.

Physical dependence, a condition that requires continued drug use to prevent withdrawal, only becomes clinically significant after several weeks of continuous drug use, although some mild degree of physical dependence may develop after a few days of use. drug therapy. Tolerability, in which higher and higher doses are required to obtain the same degree of pain relief, first manifests itself in a reduction in the duration of the analgesic effect, and then in a decrease in the intensity of pain relief. The rate of development of tolerance in different patients is different.

Drug Interactions


Patients receiving other narcotics, antihistamines, antipsychotics, sedatives, or other CNS depressants (including alcohol) concomitantly with NORCO may exhibit additive CNS depression. If combination therapy is contemplated, the dose of one or both agents should be reduced.

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The use of MAO inhibitors or tricyclic antidepressants with hydrocodone preparations may increase the effect of the antidepressant or hydrocodone.

Drug Interactions / Lab Tests

Acetaminophen may cause false positive urine test results for 5-hydroxyindoleacetic acid.




Acetaminophen has been associated with cases of acute liver failure, sometimes leading to liver transplantation and death. Most cases of liver damage are associated with the use of acetaminophen at doses in excess of 4,000 milligrams per day and are often associated with more than one acetaminophen-containing product. Overconsumption of paracetamol may be intentional for self-harm or unintentional as patients try to get more pain relief or unknowingly take other products containing acetaminophen.

The risk of acute liver failure is higher in people with underlying liver disease and in people who drink alcohol while taking paracetamol.

Instruct patients to look for acetaminophen or APAP on package labels and not to use more than one product containing paracetamol. Instruct patients to seek medical attention immediately if taking more than 4,000 milligrams of paracetamol per day, even if they feel well.

Serious skin reactions

In rare cases, acetaminophen can cause serious skin reactions such as acute generalized exanthematous pustulosis (AGEP), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), which can be fatal. Patients should be informed of the signs of serious skin reactions and the drug should be discontinued at the first appearance of a skin rash or any other sign of hypersensitivity.


There have been post-marketing reports of hypersensitivity and anaphylaxis associated with the use of acetaminophen. Clinical signs included swelling of the face, mouth, and throat, respiratory distress, urticaria, rash, itching, and vomiting. Rarely, there have been reports of life-threatening anaphylaxis requiring emergency medical attention. Instruct patients to stop taking NORCO immediately and seek medical attention if they experience these symptoms. Do not administer NORCO to patients allergic to paracetamol.

Respiratory depression

At high doses or in sensitive patients, hydrocodone may cause dose-dependent respiratory depression by acting directly on the respiratory center of the brainstem. Hydrocodone also affects the center that controls the respiratory rhythm and can cause irregular and periodic breathing.

Head trauma and increased intracranial pressure

The respiratory depressant effects of drugs and their ability to increase cerebrospinal fluid pressure may be markedly exaggerated in the presence of head trauma, other intracranial lesions, or pre-existing increased intracranial pressure. In addition, drugs cause adverse reactions that may obscure the clinical course of patients with head injuries.

Acute abdominal conditions

Drug administration may obscure the diagnosis or clinical course of patients with acute abdominal conditions.



Special Risk Patients

As with any narcotic analgesic, NORCO should be used with caution in elderly or debilitated patients and in patients with severe hepatic or renal impairment, hypothyroidism , disease Addison, prostatic hypertrophy or urethral stricture. The usual precautions should be observed and the possibility of respiratory depression should be kept in mind.

Cough reflex

Hydrocodone inhibits the cough reflex; As with all drugs, caution should be exercised when using NORCO tablets in the postoperative period and in patients with pulmonary disease.

Laboratory tests

In patients with severe liver or kidney disease, the effect of therapy should be monitored by serial tests of liver and/or kidney function.

Carcinogenesis, mutagenesis, impaired fertility

No adequate animal studies have been conducted to determine if NORCO has the potential to cause carcinogenesis, mutagenesis, or impair fertility.

Teratogenic effects

Pregnancy category C : There are no adequate and well-controlled studies in pregnant women. NORCO should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Non-teratogenic effects

Infants born to mothers who regularly took opioids prior to birth will be physically dependent. Withdrawal signs include irritability and excessive crying, tremors, hyperactive reflexes, rapid breathing, rapid stools, sneezing, yawning, vomiting, and fever. The severity of the syndrome does not always correlate with the duration of maternal opioid use or dose. There is no consensus on how best to deal with withdrawal symptoms.

Handling and delivery

As with all drugs, administration of this product to the mother shortly before delivery may result in some degree of respiratory depression in the neonate, especially at higher doses.

Nursing mothers

Acetaminophen is excreted in breast milk in small amounts, but the significance of its effects on infants is unknown. It is not known if hydrocodone is excreted in breast milk. Because many drugs are excreted in breast milk and because of the potential for serious adverse reactions in nursing infants to hydrocodone and acetaminophen, a decision should be made whether to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother.

Pediatric use

Safety and efficacy in pediatric patients have not been established.

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Geriatric Use

Clinical studies of hydrocodone bitartrate 5 mg and acetaminophen 500 mg did not include sufficient numbers of subjects aged 65 years and older to determine if they respond differently than younger subjects. Other reported clinical experience has found no difference in response between older and younger patients. In general, dose selection for the elderly patient should be cautious, usually starting at the lower end of the dosing range, reflecting a greater incidence of decreased hepatic, renal, or cardiac function, as well as concomitant disease or other drug therapy.

Overdose and contraindications


Acute overdose may result in toxic effects of hydrocodone or acetaminophen.

Signs and symptoms

Severe hydrocodone overdose is characterized by respiratory depression (decrease in respiratory rate and/or tidal volume, Cheyne-Stokes respiration, cyanosis), severe drowsiness progressing to stupor or coma, skeletal muscle laxity, cold and clammy skin, and sometimes bradycardia, etc. hypotension. In severe overdose, sleep apnea, circulatory failure, cardiac arrest and death can occur.


In paracetamol overdose: dose-dependent, potentially fatal liver necrosis is the most serious side effect. Renal tubular necrosis, hypoglycemic coma, and clotting disorders may also occur. Early symptoms after a potentially hepatotoxic overdose may include nausea, vomiting, sweating, and general malaise. Clinical and laboratory evidence of liver toxicity may not appear until 48-72 hours after ingestion.


A single or multiple overdose of hydrocodone and acetaminophen is a potentially fatal polydrug overdose, so it is recommended that you consult your local poison control center. Immediate treatment includes support for cardiorespiratory function and measures to reduce drug absorption. Oxygen, intravenous fluids, vasopressors, and other supportive measures should be used as directed. Assisted or controlled ventilation should also be considered.

In the event of an overdose of hydrocodone, the main focus should be on restoring adequate respiratory exchange by maintaining an airway and establishing assisted or controlled ventilation. The narcotic antagonist naloxone hydrochloride is a specific antidote for respiratory depression that may result from overdose or unusual drug sensitivity, including hydrocodone. Since the duration of action of hydrocodone may exceed that of the antagonist, the patient should be monitored continuously and repeated doses of the antagonist should be administered as needed to maintain adequate respiration. A narcotic antagonist should not be given in the absence of clinically significant respiratory or cardiovascular depression.

Gastric decontamination with activated charcoal should be performed immediately prior to administration of N-acetylcysteine ​​(NAC) to reduce systemic absorption if paracetamol is known or suspected to have occurred within hours of intake. Paracetamol serum levels should be obtained immediately if the patient presents 4 hours or more after ingestion, to evaluate the potential risk of hepatotoxicity; Acetaminophen levels obtained less than 4 hours after ingestion can be misleading. For best results, NAC should be administered as soon as possible when impending or developing liver damage is suspected. NAC may be administered intravenously when circumstances preclude oral administration.

Severe intoxication requires vigorous supportive care. Procedures that limit continued absorption of the drug should be performed without delay, as liver damage is dose-dependent and occurs in the early stages of intoxication.


NORCO should not be used in patients with a history of hypersensitivity to hydrocodone or acetaminophen.

Patients with hypersensitivity to other opioids may show cross-sensitivity to hydrocodone.

Clinical pharmacology


Hydrocodone is a semi-synthetic narcotic analgesic and antitussive agent with many actions qualitatively similar to those of codeine. Most of them affect the central nervous system and smooth muscles. The exact mechanism of action of hydrocodone and other opiates is unknown, although it is thought to be related to the existence of opiate receptors in the central nervous system. In addition to pain relief, drugs can cause drowsiness, mood changes, and clouding of the mind.

The analgesic action of paracetamol is associated with peripheral effects, but the specific mechanism has not yet been determined. The antipyretic effect is transmitted through the hypothalamic heat regulation centers. Acetaminophen inhibits prostaglandin synthetase. Therapeutic doses of paracetamol have little effect on the cardiovascular or respiratory systems; however, toxic doses can cause circulatory failure and shallow breathing.


The behavior of the individual components is described below.


Following oral administration of 10 mg hydrocodone to five adult males, the mean peak concentration was 23.6 ± 5.2 ng/mL. Peak serum levels were reached at 1.3 ± 0.3 hours and the half-life was 3.8 ± 0.3 hours. Hydrocodone exhibits a complex metabolic pattern, including O-demethylation, N-demethylation, and reduction of 6-keto to the corresponding 6-α- and 6-β-hydroxy metabolites. See OVERDOSE for toxicity information.

Can I take cyclobenzaprine with tramadol?


Acetaminophen is rapidly absorbed from the gastrointestinal tract and distributed to most body tissues. The plasma half-life ranges from 1.25 to 3 hours, but may increase with liver damage and after overdose. Excretion of paracetamol occurs mainly due to metabolism (conjugation) in the liver and subsequent excretion of metabolites by the kidneys. Approximately 85% of an oral dose is excreted in the urine within 24 hours of ingestion, primarily as the glucuronide conjugate with small amounts of other conjugates and unchanged drug. see OVERDOSE for toxicity information.

Medication Guide


  • Do not take NORCO if you are allergic to any of its ingredients.
  • If you develop signs of an allergy, such as a rash or difficulty breathing, stop taking NORCO and contact your doctor immediately.
  • Do not take more than 4000 milligrams of paracetamol per day. If you have taken more than the recommended dose, call your doctor.

Hydrocodone, like all narcotics, may impair the mental and/or physical abilities required to perform potentially hazardous tasks such as driving a car or operating machinery; patients should be warned accordingly.

Alcohol and other CNS depressants may cause additional CNS depression when taken with this combination product and should be avoided.

Hydrocodone may be habit-forming. Patients should only take the drug for as long as it is prescribed, in the prescribed amounts, and no more frequently than prescribed.

🎖▷ Why you don’t have to worry about weight gain with Lamictal

If you’re worried that taking Lamictal (lamotrigine) might cause weight gain, there’s good news. It probably won’t affect your weight much. If anything, you’re more likely to lose weight due to Lamictal than gain weight, but either way, the changes are likely to be pretty small.
The effect of Lamictal on weight has been little studied, and various clinical trials have found minimal effect. In fact, some researchers even considered the drug as a possible remedy for obesity and as a remedy for overeating. This information should be reassuring for people with bipolar disorder, as many of the medications used to treat this condition can cause weight gain.

Lamictal findings and weight gain or loss
Lamictal is an anticonvulsant that can be used to treat seizures such as epilepsy. It is also used as a mood stabilizer for bipolar disorder.
In the first clinical trials with the drug, 5 percent of adults with epilepsy lost weight while taking Lamictal, while 1 to 5 percent of patients with bipolar I disorder gained weight while taking the drug. The researchers do not disclose how much weight patients have gained or lost.
Meanwhile, a 2006 study comparing the effects on weight of Lamictal, lithium, and placebo found that some Lamictal-treated patients gained weight, some lost weight, and most remained about the same weight. Weight changes are usually not many pounds anyway. Obese patients taking Lamictal lost an average of four pounds, while the weight of non-obese patients remained virtually unchanged.
Relationship between weight gain and other bipolar drugs
Weight gain from medications used to treat bipolar disorder is unfortunately quite common. Some mood stabilizers commonly used for bipolar disorder, especially lithium and Depakote (valproate), carry a high risk of weight gain.
In addition, the atypical antipsychotics Clozaril (clozapine) and Zyprexa (olanzapine) tend to cause significant weight gain in people who take them. Finally, some antidepressants, notably Paxil (paroxetine) and Remeron (mirtazapine), have been associated with weight gain.
Therefore, if you are already overweight, you and your psychiatrist may want to consider additional weight gain when determining your bipolar medication regimen. Based on this, Lamictal may be a good choice.
Lamictal as a possible treatment for obesity
Lamictal has also been studied as a possible treatment for obesity in people without epilepsy or bipolar disorder.
In a small 40-person clinical trial conducted in 2006, researchers randomly assigned participants to receive either lamictal or placebo for up to 26 weeks. Each participant in the study had a body mass index (BMI) between 30 and 40, placing them in the obese group to the level of severe obesity. Those who took Lamictal lost an average of just over 10 pounds. Those who took the placebo lost about 7 pounds in the meantime, so while those who took Lamictal lost more weight, they didn’t lose all that much more.
Another study in 2009 looked at Lamictal as a remedy for overeating. This study involved 51 people with the condition that 26 of them received Lamictal, and 25 – placebo.
Those who took Lamictal lost more weight than those who took placebo (about 2.5 pounds versus about one-third of a pound) and did have significant improvements in blood sugar and cholesterol lab test results. However, Lamictal did not appear to affect other aspects of the eating disorder when compared to placebo.