What are the primary uses of Cytotec. How does misoprostol work to prevent stomach ulcers. What are the most common side effects of Cytotec. Who should avoid taking misoprostol. How is Cytotec administered for different medical purposes. What precautions should be taken when using misoprostol.

Understanding Cytotec: A Multifaceted Medication

Cytotec, also known by its generic name misoprostol, is a versatile medication with multiple applications in medical practice. It’s primarily used to prevent stomach ulcers in patients taking nonsteroidal anti-inflammatory drugs (NSAIDs) and plays a role in obstetrics and gynecology. Understanding its uses, benefits, and potential risks is crucial for patients and healthcare providers alike.

What is Cytotec?

Cytotec is a synthetic prostaglandin E1 analog that has been FDA-approved for the prevention of gastric ulcers associated with NSAID use. Its ability to protect the stomach lining and reduce acid secretion makes it valuable in gastroenterology. However, its effects on the uterus have led to off-label uses in obstetrics and gynecology.

Primary Uses of Cytotec in Medical Practice

Cytotec serves multiple purposes in healthcare settings. Its diverse applications showcase its importance in modern medicine.

• Prevention of NSAID-induced gastric ulcers
• Induction of labor
• Medical management of miscarriage
• Cervical ripening before surgical procedures
• Treatment of postpartum hemorrhage

Can Cytotec be used for gastric ulcer prevention in all patients taking NSAIDs? No, it’s specifically recommended for patients at high risk of developing ulcers or those with a history of ulcers. Healthcare providers assess individual risk factors before prescribing Cytotec for this purpose.

Mechanism of Action: How Cytotec Works

Understanding how Cytotec functions in the body helps explain its diverse medical applications and potential side effects.

Gastric Protection

In the stomach, Cytotec works by:

1. Decreasing acid secretion
2. Increasing mucus production
3. Enhancing bicarbonate secretion
4. Improving blood flow to the gastric mucosa

These actions collectively protect the stomach lining from the damaging effects of NSAIDs and stomach acid.

Uterine Effects

Cytotec’s impact on the uterus includes:

• Stimulating uterine contractions
• Softening and dilating the cervix
• Increasing prostaglandin levels in the uterine tissue

These effects explain its use in obstetrics and gynecology for labor induction and management of certain pregnancy-related conditions.

Side Effects and Risks Associated with Cytotec Use

While Cytotec can be highly beneficial, it’s not without potential side effects and risks. Patients should be aware of these possibilities and report any concerning symptoms to their healthcare provider promptly.

Common Side Effects

• Diarrhea
• Abdominal pain
• Nausea
• Flatulence
• Headache
• Dizziness

Are these side effects typically severe or long-lasting? In most cases, these side effects are mild and transient. However, if they persist or worsen, medical attention should be sought.

Serious Risks and Complications

While rare, serious complications can occur, especially when Cytotec is used for obstetric purposes:

• Uterine rupture
• Severe vaginal bleeding
• Infection
• Birth defects (if used during pregnancy)

The risk of uterine rupture is particularly concerning and increases with advancing gestational age, prior uterine surgery, or multiple previous pregnancies.

Contraindications and Precautions for Cytotec Use

Certain individuals should not use Cytotec or should use it with extreme caution under close medical supervision.

Absolute Contraindications

• Pregnancy (when used for ulcer prevention)
• Allergy to misoprostol or other prostaglandins
• Unexplained vaginal bleeding

Relative Contraindications

• History of cesarean section or other uterine surgery
• Grand multiparity (five or more previous pregnancies)
• Inflammatory bowel disease
• Cardiovascular disease

Why is pregnancy a contraindication for Cytotec when used for ulcer prevention? Cytotec can cause miscarriage, premature birth, or birth defects. Its use during pregnancy for ulcer prevention is not justified given these serious risks.

Proper Administration and Dosage Guidelines

The administration and dosage of Cytotec vary depending on its intended use. Proper adherence to prescribed guidelines is crucial for safety and efficacy.

For Ulcer Prevention

• Typical dose: 200 mcg four times daily with food
• Last dose usually taken at bedtime
• Continue for duration of NSAID therapy

For Obstetric and Gynecologic Uses

Dosages and administration routes vary widely based on the specific indication and should always be determined and supervised by a healthcare professional.

Is it safe to adjust Cytotec dosage without consulting a healthcare provider? No, patients should never adjust their Cytotec dosage without medical guidance. Doing so could lead to ineffective treatment or increased risk of side effects.

Interactions with Other Medications and Substances

Cytotec can interact with various medications and substances, potentially altering its effectiveness or increasing the risk of side effects.

Notable Interactions

• Antacids containing magnesium: May worsen diarrhea
• NSAIDs: May decrease the gastroprotective effects of Cytotec
• Oxytocic agents: May enhance uterine contractions

Patients should always inform their healthcare provider about all medications, supplements, and herbal products they are taking before starting Cytotec.

Alcohol and Cytotec

While no direct interactions between alcohol and Cytotec have been established, alcohol can irritate the stomach lining and potentially counteract the gastroprotective effects of Cytotec. Patients taking Cytotec for ulcer prevention should discuss alcohol consumption with their healthcare provider.

Special Considerations for Women of Childbearing Age

Women of childbearing potential require special considerations when prescribed Cytotec due to its potential effects on pregnancy.

Strict Requirements

Female patients of childbearing age must meet specific criteria before using Cytotec:

1. Negative pregnancy test within two weeks before starting treatment
2. Use of effective contraception
3. Receive comprehensive counseling about risks
4. Start Cytotec only on the second or third day of the next normal menstrual period

Contraception During and After Treatment

Effective contraception is crucial while taking Cytotec and for at least one month or one complete menstrual cycle after discontinuation. This precaution helps prevent potential pregnancy complications associated with Cytotec use.

What should a woman do if she suspects pregnancy while taking Cytotec? She should immediately discontinue the medication and contact her healthcare provider for guidance and evaluation.

Monitoring and Follow-up During Cytotec Treatment

Regular monitoring and follow-up are essential components of safe and effective Cytotec use, regardless of the indication.

For Ulcer Prevention

• Regular check-ups to assess efficacy and side effects
• Periodic evaluation of continued need for NSAID therapy
• Monitoring for signs of gastrointestinal bleeding

For Obstetric and Gynecologic Uses

• Close monitoring of uterine activity and fetal status during labor induction
• Follow-up after medical management of miscarriage to ensure completion
• Monitoring for excessive bleeding or signs of infection

How often should patients have follow-up appointments when using Cytotec for ulcer prevention? The frequency of follow-up appointments can vary based on individual patient factors, but typically, an initial follow-up within 4-6 weeks of starting treatment is recommended, with subsequent visits as determined by the healthcare provider.

Alternative Treatments and Considerations

While Cytotec is effective for its approved uses, alternative treatments may be considered in certain situations.

Alternatives for Ulcer Prevention

• Proton pump inhibitors
• H2 receptor antagonists
• Cytoprotective agents like sucralfate

Alternatives in Obstetrics and Gynecology

• Other prostaglandin analogs
• Mechanical methods for cervical ripening
• Surgical management for certain conditions

The choice of treatment should be made in consultation with a healthcare provider, considering individual patient factors, potential risks, and benefits.

Long-term Outlook and Prognosis with Cytotec Use

The long-term outlook for patients using Cytotec depends on the indication for use and individual patient factors.

For Ulcer Prevention

Long-term use of Cytotec for ulcer prevention is generally well-tolerated. However, the need for continued therapy should be periodically reassessed, especially if the underlying risk factors for ulcers have changed.

For Obstetric and Gynecologic Uses

Cytotec use in these settings is typically short-term, and long-term effects are not a significant concern. However, proper follow-up is crucial to ensure complete resolution of the condition being treated and to monitor for any complications.

Can long-term use of Cytotec for ulcer prevention lead to dependence? No, Cytotec does not cause physical dependence. However, abrupt discontinuation in patients taking NSAIDs could potentially lead to an increased risk of ulcers if alternative gastroprotective measures are not implemented.

Patient Education and Empowerment

Educating patients about Cytotec is crucial for ensuring safe and effective use of the medication.

Key Points for Patient Education

• Importance of adhering to prescribed dosage and administration instructions
• Recognition of potential side effects and when to seek medical attention
• Understanding of contraindications and necessary precautions
• Awareness of the need for effective contraception when applicable
• Importance of follow-up appointments and open communication with healthcare providers

Empowering Patients

Patients should be encouraged to:

• Ask questions about their treatment
• Report any concerning symptoms promptly
• Keep a record of their medication use and any side effects experienced
• Participate actively in decisions about their healthcare

How can patients best prepare for discussions with their healthcare providers about Cytotec? Patients can prepare by keeping a detailed record of their symptoms, side effects, and any questions or concerns they have. They should also bring a list of all medications and supplements they are taking to each appointment.

Future Directions and Ongoing Research

Research into Cytotec and its applications continues to evolve, potentially expanding its uses and improving its safety profile.

Areas of Ongoing Research

• Development of new formulations with reduced side effects
• Exploration of additional medical applications
• Investigation of combination therapies for enhanced efficacy
• Long-term safety studies in specific patient populations

Potential Future Applications

Researchers are exploring the potential use of Cytotec in:

• Treatment of certain types of glaucoma
• Management of certain gastrointestinal motility disorders
• Novel approaches to labor induction and cervical ripening

How might future research impact the current uses of Cytotec? Ongoing studies may lead to refined dosing regimens, improved safety profiles, or expanded indications for use. However, any changes to current practice will require rigorous clinical trials and regulatory approval.

Navigating the Regulatory Landscape

The regulatory status of Cytotec varies globally, impacting its availability and approved uses.

FDA Status in the United States

In the U.S., Cytotec is FDA-approved for the prevention of NSAID-induced gastric ulcers. Its use in obstetrics and gynecology is considered off-label, though widely accepted in clinical practice.

Global Regulatory Variations

Regulatory approval and guidelines for Cytotec use can differ significantly between countries. Some nations have approved it for broader uses, while others have more restrictive policies.

Why do regulatory approvals for Cytotec differ between countries? Variations in regulatory approvals often stem from differences in local clinical practices, healthcare systems, and interpretations of available research data. Additionally, cultural and ethical considerations can influence regulatory decisions, particularly regarding its use in obstetrics and gynecology.

Ethical Considerations in Cytotec Use

The use of Cytotec, particularly in obstetrics and gynecology, raises important ethical considerations that healthcare providers and patients must navigate.

Balancing Risks and Benefits

Healthcare providers must carefully weigh the potential benefits of Cytotec against its risks, especially in off-label uses. This involves thorough patient counseling and informed consent processes.

Access and Equity Issues

In some regions, Cytotec’s availability and affordability make it a crucial option for managing certain obstetric and gynecologic conditions, particularly in resource-limited settings. However, this raises questions about equitable access to safer alternatives where available.

Ethical Use in Reproductive Health

The use of Cytotec in managing early pregnancy loss or for elective pregnancy termination is subject to ongoing ethical debates and varying legal frameworks globally.

How do healthcare providers navigate the ethical complexities of Cytotec use? Providers must stay informed about current guidelines, engage in open and honest communication with patients, respect individual autonomy, and adhere to local legal and ethical standards. Regular ethical training and case discussions can help providers navigate these complex issues.

Cytotec Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Warnings:

Do not take this medication if you think that you may be pregnant. It may cause a pregnancy to end, premature birth, or birth defects. In rare cases, serious complications (such as uterine rupture) have occurred when misoprostol was used to start labor or end a pregnancy. These complications have resulted in harm to the unborn baby and mother. The risk for uterine rupture increases as your pregnancy advances and if you had prior uterine surgery (including Cesarean delivery) or if you had five or more previous pregnancies.

Avoid pregnancy while taking misoprostol and for at least one month or one completed menstrual cycle after you have stopped treatment. If you become pregnant while taking misoprostol, contact your doctor right away.

If you are pregnant, do not take this medication to reduce the risk of stomach ulcers due to aspirin or other related drugs (non-steroidal anti-inflammatory drugs-NSAIDs such as ibuprofen). Also, if you are of childbearing age, do not use this drug to reduce the risk of ulcers from NSAIDs unless you are at high risk of having an ulcer or ulcer complications.

Female patients must meet the following four requirements in order to use this drug: 1) test negative for pregnancy within two weeks before starting treatment; 2) use effective birth control to prevent pregnancy; 3) receive oral and written warnings on the dangers of using misoprostol while of childbearing age and the risks of possible birth control failure; 4) start taking misoprostol only on the second or third day of the next normal menstrual period.

This medication must not be shared with others.

Warnings:

Do not take this medication if you think that you may be pregnant. It may cause a pregnancy to end, premature birth, or birth defects. In rare cases, serious complications (such as uterine rupture) have occurred when misoprostol was used to start labor or end a pregnancy. These complications have resulted in harm to the unborn baby and mother. The risk for uterine rupture increases as your pregnancy advances and if you had prior uterine surgery (including Cesarean delivery) or if you had five or more previous pregnancies.

Avoid pregnancy while taking misoprostol and for at least one month or one completed menstrual cycle after you have stopped treatment. If you become pregnant while taking misoprostol, contact your doctor right away.

If you are pregnant, do not take this medication to reduce the risk of stomach ulcers due to aspirin or other related drugs (non-steroidal anti-inflammatory drugs-NSAIDs such as ibuprofen). Also, if you are of childbearing age, do not use this drug to reduce the risk of ulcers from NSAIDs unless you are at high risk of having an ulcer or ulcer complications.

Female patients must meet the following four requirements in order to use this drug: 1) test negative for pregnancy within two weeks before starting treatment; 2) use effective birth control to prevent pregnancy; 3) receive oral and written warnings on the dangers of using misoprostol while of childbearing age and the risks of possible birth control failure; 4) start taking misoprostol only on the second or third day of the next normal menstrual period.

This medication must not be shared with others.

… Show More

Uses

This medication is used to prevent stomach ulcers while you take NSAIDs (such as aspirin, ibuprofen, naproxen), especially if you are at risk for developing ulcers or have a history of ulcers. Misoprostol helps to decrease your risk of serious ulcer complications such as bleeding. This medication protects your stomach lining by lowering the amount of acid that comes in contact with it.This medication is also used in combination with another drug (mifepristone) to end a pregnancy.

How to use Cytotec

This medicine comes with a patient information leaflet. Read it carefully. If you have any questions about this drug, ask your doctor, nurse, or pharmacist.

Dosage is based on your medical condition and response to therapy.

If you are taking this drug to prevent stomach ulcers, take it by mouth as directed by your doctor, usually four times a day. Take it after meals and at bedtime to minimize diarrhea.

If you are taking this medication to end a pregnancy, take it by mouth exactly as directed by your doctor.

If you are using this medication to start labor, your healthcare professional will insert it into your vagina.

Avoid taking antacids that contain magnesium while using misoprostol because they may make the diarrhea it causes worse. If you need an antacid, consult your doctor or pharmacist to help you choose a product.

For ulcer prevention, continue to take this drug for as long as you take NSAIDs. Use this medication regularly in order to get the most benefit from it. Remember to use it at the same times each day.

Inform your doctor if your condition lasts or gets worse.

Side Effects

Nausea or stomach cramps may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Diarrhea is common with misoprostol and usually occurs about two weeks after you start taking it, and lasts for about a week. Be sure to keep up your intake of fluids and minerals/electrolytes to prevent dehydration. Diarrhea that doesn’t stop may sometimes lead to a large loss of your body’s water and minerals. Tell your doctor right away if you develop any of these serious signs of dehydration and mineral imbalance: dizziness, decreased urination, mental/mood changes, muscle weakness, slow/irregular heartbeat.

Tell your doctor right away if you have any serious side effects, including: menstrual problems or irregularities, unusual/heavy vaginal bleeding.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking misoprostol, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: stomach/intestinal disease (such as inflammatory bowel disease).

Daily use of alcohol and tobacco may increase your risk for stomach bleeding. Limit alcohol beverages and stop smoking. Consult your doctor or pharmacist for more information.

If you are taking this medication in combination with mifepristone to end a pregnancy, rarely the pregnancy may not end. It is very important for you to be closely monitored by your doctor and to keep your scheduled appointments to follow your progress. Be sure to have clear instructions from your doctor about who to call and what to do in case of an emergency. Expect vaginal bleeding after you take the combined medicine, however tell your doctor right away if you develop any unlikely symptoms such as severe/prolonged vaginal bleeding, signs of infection (including fever, chills), or fainting.

This drug must not be used during pregnancy to prevent stomach ulcers because of possible harm to an unborn baby (see also Warnings). If you are of childbearing age, use effective birth control methods while taking misoprostol and for at least one month or one completed menstrual cycle after you stop taking it. If you become pregnant or think you may be pregnant, inform your doctor right away.

This medication passes into breast milk. However, this drug is unlikely to harm a nursing infant. Consult your doctor before breast-feeding.

Interactions

See also the How to Use section.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Does Cytotec interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe drowsiness, seizures, severe dizziness, slow/irregular heartbeats.

Do not share this medication with others.

If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.

Store at or below 77 degrees F (25 degrees C) in a dry place away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Images

Cytotec 200 mcg tablet

Color: whiteShape: hexagonalImprint: SEARLE 1461 a double stomach

This medicine is a white, hexagonal, scored, tablet imprinted with “SEARLE 1461” and “a double stomach”.

Cytotec 100 mcg tablet

Color: whiteShape: roundImprint: SEARLE 1451

This medicine is a white, hexagonal, scored, tablet imprinted with “SEARLE 1461” and “a double stomach”.

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Cytotec Uses, Side Effects & Warnings

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Generic name: misoprostol [ mye-so-PRAH-stole ]
Drug class: Miscellaneous GI agents

Medically reviewed by Drugs.com on Nov 30, 2022. Written by Cerner Multum.

What is Cytotec?

Cytotec is used to prevent stomach ulcers during treatment with nonsteroidal anti-inflammatory drugs (NSAID) such as aspirin, ibuprofen, naproxen, celecoxib, diclofenac, indomethacin, meloxicam, and others.

Cytotec may also be used for purposes not listed in this medication guide.

Warnings

Cytotec can cause birth defects, premature birth, uterine rupture, miscarriage, or incomplete miscarriage and dangerous uterine bleeding. Do not use this medicine if you are pregnant.

If you are able to become pregnant, you will need to have a negative pregnancy test before starting this treatment. You will also need to use effective birth control to prevent pregnancy during treatment.

Before taking this medicine

You should not use Cytotec if you are allergic to Cytotec or other prostaglandins, or if you are pregnant.

Tell your doctor if you have ever had:

May cause birth defects. Do not use if you are pregnant. You must use effective birth control while using Cytotec and for at least 1 month after your last dose. Tell your doctor if you become pregnant.

You will need to have a negative pregnancy test before starting this treatment.

Stop taking this medicine and tell your doctor right away if you become pregnant during treatment.

Ask a doctor if it is safe to breastfeed while using this medicine.

How should I take Cytotec?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Do not share this medicine with another person, even if they have the same symptoms you have.

Cytotec is usually taken four times a day with meals. The last dose of the day should be at bedtime. Follow your doctor’s instructions.

You may have nausea, stomach cramps, or diarrhea while taking this medicine, especially during the first few weeks after you start taking Cytotec. These symptoms usually last for about a week.

Call your doctor if you have severe nausea, stomach pain, or diarrhea lasting longer than 8 days.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Cytotec?

Follow your doctor’s instructions about any restrictions on food, beverages, or activity.

Cytotec side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Cytotec may cause serious side effects. Call your doctor at once if you have:

• severe ongoing stomach discomfort or diarrhea; or

• dehydration–dizziness, confusion, feeling very thirsty, less urination.

Common side effects of Cytotec may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Cytotec?

Tell your doctor about all your other medicines, especially:

• antacids.

This list is not complete. Other drugs may affect Cytotec, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

More about Cytotec (misoprostol)

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Patient resources

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• Prescribing Information

Related treatment guides

• Duodenal Ulcer
• NSAID-Induced Ulcer Prophylaxis
• Stomach Ulcer

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Copyright 1996-2023 Cerner Multum, Inc. Version: 10.01.

Cytotec instructions for use: indications, contraindications, side effects – description Cytotec Tablets (5334)

Cytotec :: Instructions :: Price :: Description of the drug Additive components: MCC, aerosil, sodium CMC, hypromellose, castor oil.

The active substance of Cytotec tablets is a synthesized analogue of prostaglandin E1 produced by the body. This molecule enhances the protective properties of the gastrointestinal mucosa by stimulating the production of mucus by the glandular cells of the stomach, enhancing the natural secretion of bicarbonate molecules.

It increases the resistance of the gastrointestinal mucosa, preventing aggressive components from food, alcoholic beverages, therapeutic drugs from harming the cells that form the gastrointestinal mucosa. Cytotec has the following effects:

– causes acid neutralization by enhancing the synthesis of bicarbonates;

– protects the walls of the stomach from aggressive molecules by increasing the production of mucus, improving its qualitative composition;

– improves blood supply to the gastrointestinal mucosa with stimulation of regenerative processes.

The misoprostol molecule reduces the production of pepsi molecules. The therapeutic effect starts 30 minutes after the use of the dosage form, lasts about 180 minutes. Misoprostol provokes contraction of the myometrium, increases the intensity of contractions.

Cytotec is prescribed for:

• the need to use NSAIDs;
• peptic ulcer of any localization;
• duodenal ulcer with or without bleeding;
• gastric ulcer with or without bleeding.

Cytotec tablet is taken by mouth. It is indicated to use the dosage form directly with food, after meals and before going to bed. For the treatment of ulcerative lesions of the gastrointestinal tract, gastritis with mucosal erosions, the daily dose is 0.8 mg divided into 2-4 doses.

In order to prevent the development of ulcerative lesions of the gastrointestinal tract, 0.4-0.8 mg / day is prescribed with a dose divided into 2-4 doses. If necessary, therapy with drugs of the NSAID group is indicated to take Cytotec during the entire treatment. During the period of exacerbation of duodenal ulcer, the drug should be taken for 1 month. A month later, endoscopy is done. If incomplete scarring is detected, the course is extended for another month.

The use of Cytotec tablets may be accompanied by:

• constipation;
• dysmenorrhea;
• diarrhea;
• skin rashes;
• pain in the lower abdomen;
• asthenia;
• gagging;
• headaches;
• hypermenorrhea;
• bloody vaginal discharge;
• bouts of nausea;
• change in body weight;
• convulsions;
• flatulence;
• epigastric pains.

Cytotec is not prescribed for:

• severe liver pathologies;
• arterial hypotension;
• acute renal failure;
• disorders of cerebral circulation;
• intestinal pathologies associated with inflammation;
• pregnancy;
• pregnancy planning;
• indications in premenopausal patients;
• indications in nursing;
• hypersensitivity to misoprostol;
• indications in patients under 17 years of age.

Caution is required when prescribing Cytotec tablets for:

• organic pathologies of cerebral vessels;
• acute peripheral circulatory disorders;
• epilepsy.

Cytotec tablets may cause self-abortion. The use of misoprostol-containing agents during pregnancy and suspected pregnancy is contraindicated.

The use of the drug in dosages that exceed therapeutic may be accompanied by the following symptoms:

convulsive syndrome.

It is indicated to carry out the therapy corresponding to the appeared symptomatology.

Cytotec is available in tablet form. Packing: 50 tablets/package.

Storage temperature of Cytotec tablets is up to 30 degrees Celsius. The shelf life of the drug is 3 years.

Misoprostol, Mirolut, Misoprostol-HPMC, Cytotec.

See also Cytotec analogue list.

Misoprostol

A02BB01

Dose adjustment for geriatric patients is not required. For patients with diseases of the kidneys, liver and violation of their functions, standard dosing regimens are prescribed.

Pregnancy tests should be ordered for patients of childbearing age. Misoprostol is indicated to be administered a few days after the onset of normal menstruation. It is shown to use reliable contraceptive methods during therapy with Cytotec. This therapeutic agent can provoke an abortion due to a stimulating effect on the tone of the uterus.