What are the major drug interactions with cefdinir. How does cefdinir work in the body. What conditions can cefdinir be used to treat. What are important precautions when taking cefdinir. How should cefdinir be dosed and administered.

Understanding Cefdinir and Its Mechanism of Action

Cefdinir is a third-generation cephalosporin antibiotic used to treat various bacterial infections. It works by interfering with bacterial cell wall synthesis, ultimately leading to cell death. Specifically, cefdinir binds to and inhibits enzymes called penicillin-binding proteins that are crucial for building the peptidoglycan layer of bacterial cell walls.

As a broad-spectrum antibiotic, cefdinir is effective against many gram-positive and gram-negative bacteria. It has bactericidal (bacteria-killing) activity similar to penicillin antibiotics. Some key features of cefdinir’s mechanism include:

• Binding to penicillin-binding proteins in bacterial cell membranes
• Disrupting cell wall synthesis and integrity
• Causing bacterial cell lysis and death
• Activity against both gram-positive and gram-negative pathogens

Common Uses and Indications for Cefdinir

Cefdinir is prescribed to treat a variety of mild to moderate bacterial infections, particularly those affecting the respiratory tract, ears, and skin. Some of the main uses and indications include:

• Community-acquired pneumonia
• Acute exacerbations of chronic bronchitis
• Acute bacterial sinusitis
• Pharyngitis/tonsillitis
• Acute otitis media (middle ear infection)
• Uncomplicated skin and skin structure infections

Cefdinir is effective against many common bacterial pathogens involved in these infections, including susceptible strains of Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and methicillin-susceptible Staphylococcus aureus.

Important Drug Interactions with Cefdinir

When taking cefdinir, it’s crucial to be aware of potential drug interactions that may affect its efficacy or increase the risk of side effects. According to the drug interaction data, there are 45 known drug interactions with cefdinir, including 3 major and 42 moderate interactions.

Some of the most significant interactions to be aware of include:

• Antacids containing aluminum or magnesium: These can decrease cefdinir absorption. Separate administration by at least 2 hours.
• Iron supplements: Can reduce cefdinir absorption. Take iron supplements at least 2 hours before or after cefdinir.
• Probenecid: May increase cefdinir levels in the body, potentially increasing side effects.
• Oral contraceptives: Cefdinir may reduce the effectiveness of birth control pills.

Always inform your healthcare provider about all medications, supplements, and herbal products you are taking to avoid potential interactions with cefdinir.

Side Effects and Adverse Reactions

While cefdinir is generally well-tolerated, it can cause various side effects. Understanding these potential adverse reactions is important for patients and healthcare providers. Common side effects of cefdinir may include:

• Diarrhea or loose stools
• Nausea and vomiting
• Abdominal pain
• Headache
• Vaginal yeast infections
• Rash or skin reactions

In rare cases, more serious side effects can occur, such as severe allergic reactions, Clostridium difficile-associated diarrhea, or blood disorders. Patients should seek immediate medical attention if they experience severe diarrhea, signs of an allergic reaction, or unusual bleeding or bruising.

Dosage and Administration Guidelines

Proper dosing of cefdinir is essential for its effectiveness and safety. The dosage can vary depending on the type and severity of infection, as well as patient factors like age and kidney function. General dosing guidelines for adults include:

• 300 mg twice daily or 600 mg once daily for most infections
• Treatment duration typically ranges from 5 to 10 days, depending on the condition
• Doses should be adjusted for patients with impaired kidney function

For pediatric patients, dosing is usually based on body weight. It’s crucial to follow the prescribed dosage and complete the full course of treatment, even if symptoms improve before finishing the medication.

Special Considerations and Precautions

Certain patient groups and conditions require special attention when using cefdinir. Important precautions and considerations include:

• Allergy history: Patients with a history of penicillin allergy may also be allergic to cefdinir
• Kidney problems: Dose adjustments may be necessary for patients with impaired renal function
• Gastrointestinal diseases: Caution in patients with a history of colitis or other GI disorders
• Pregnancy and breastfeeding: Limited data available; use only if clearly needed
• Elderly patients: May be more susceptible to side effects; careful monitoring required

Healthcare providers should carefully evaluate the benefits and risks of cefdinir use in these patient populations.

Cefdinir in the Context of Antibiotic Resistance

As with all antibiotics, the use of cefdinir must be considered in the context of growing antibiotic resistance. Responsible use of cefdinir and other antibiotics is crucial to preserve their effectiveness. Key points to consider include:

• Use only for confirmed or strongly suspected bacterial infections
• Avoid use for viral infections like the common cold or flu
• Complete the full prescribed course of treatment
• Do not share antibiotics or use leftover medications

Healthcare providers play a vital role in educating patients about appropriate antibiotic use and the importance of following prescribed treatments accurately.

Comparing Cefdinir to Other Antibiotics

Cefdinir belongs to the third-generation cephalosporin class of antibiotics. How does it compare to other commonly prescribed antibiotics? Here’s a brief overview:

• vs. Amoxicillin: Cefdinir has a broader spectrum of activity and is less affected by beta-lactamase enzymes
• vs. Azithromycin: Cefdinir may be more effective against certain respiratory pathogens but lacks activity against atypical bacteria
• vs. First-generation cephalosporins: Cefdinir has improved gram-negative coverage and better penetration into the central nervous system

The choice between cefdinir and other antibiotics depends on the specific infection, local resistance patterns, and individual patient factors. Healthcare providers consider these aspects when selecting the most appropriate antibiotic treatment.

Patient Education and Compliance

Ensuring patient understanding and compliance is crucial for the successful use of cefdinir. Healthcare providers should emphasize the following points to patients:

• Take cefdinir exactly as prescribed, at regular intervals
• Complete the entire course of treatment, even if symptoms improve
• Report any significant side effects or allergic reactions promptly
• Avoid consuming iron supplements or iron-fortified foods within 2 hours of taking cefdinir
• Inform healthcare providers about all other medications and supplements being taken

Clear communication and patient education can help improve treatment outcomes and reduce the risk of antibiotic resistance.

Monitoring and Follow-up

Proper monitoring during cefdinir treatment is important to ensure effectiveness and detect any potential issues. Healthcare providers should consider the following:

• Assessing clinical response within 48-72 hours of starting treatment
• Monitoring for signs of allergic reactions or severe side effects
• Checking renal function in patients with known kidney issues
• Evaluating the need for culture and sensitivity testing in case of treatment failure

Regular follow-up allows for timely adjustments to treatment if necessary and helps ensure optimal patient outcomes.

Cefdinir Interactions Checker – Drugs.com

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There are 45 drugs known to interact with
cefdinir, along with
7 disease interactions, and 1 alcohol/food interaction.

Of the total drug interactions,
3 are major, and 42 are moderate.

Does cefdinir interact with my other drugs?

Enter other medications to view a detailed report.

• View all 45 medications that may interact with cefdinir
• View cefdinir alcohol/food interactions (1)
• View cefdinir disease interactions (7)

Most frequently checked interactions

View interaction reports for cefdinir and the medicines listed below.

• Major
• Moderate
• Minor
• Unknown

• Aspirin Low Strength (aspirin)
• Augmentin (amoxicillin / clavulanate)
• Benadryl (diphenhydramine)
• Claritin (loratadine)
• CoQ10 (ubiquinone)
• Cymbalta (duloxetine)
• Eliquis (apixaban)
• Fish Oil (omega-3 polyunsaturated fatty acids)
• Flexeril (cyclobenzaprine)
• Flonase (fluticasone nasal)
• Lyrica (pregabalin)
• Metoprolol Succinate ER (metoprolol)
• Metoprolol Tartrate (metoprolol)
• MiraLAX (polyethylene glycol 3350)
• Mucinex (guaifenesin)
• Norco (acetaminophen / hydrocodone)
• ProAir HFA (albuterol)
• Probiotic Formula (bifidobacterium infantis / lactobacillus acidophilus)
• Protonix (pantoprazole)
• Singulair (montelukast)
• Symbicort (budesonide / formoterol)
• Synthroid (levothyroxine)
• Tylenol (acetaminophen)
• Vitamin B12 (cyanocobalamin)
• Vitamin C (ascorbic acid)
• Vitamin D2 (ergocalciferol)
• Vitamin D3 (cholecalciferol)
• Xanax (alprazolam)
• Zofran (ondansetron)
• Zyrtec (cetirizine)

Cefdinir alcohol/food interactions

There is 1 alcohol/food interaction with cefdinir.

Cefdinir disease interactions

There are 7 disease interactions with cefdinir which include:

• colitis
• renal dysfunction
• diabetes
• nitroprusside tests
• dialysis
• liver disease
• seizure disorders

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More about cefdinir

• cefdinir consumer information
• Compare alternatives
• Pricing & coupons
• Reviews (382)
• Drug images
• Side effects
• Dosage information
• Patient tips
• During pregnancy
• Support group
• Drug class: third generation cephalosporins
• Breastfeeding
• En español

Related treatment guides

• Bacterial Infection
• Otitis Media
• Pneumonia
• Bronchitis

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.

Major	Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate	Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor	Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown	No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Cefdinir: 7 things you should know

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Medically reviewed by Carmen Fookes, BPharm. Last updated on Aug 29, 2022.

1. How it works

• Cefdinir is an antibiotic used to treat mild infections caused by susceptible gram-positive and gram-negative bacteria.
• Cefdinir works by binding to and blocking the activity of enzymes responsible for making peptidoglycan, an important component of the bacterial cell wall. They are called broad-spectrum antibiotics because they are effective against a wide range of bacteria. Cefdinir is bactericidal (kill bacteria) and works in a similar way to penicillin.
• Cefdinir belongs to the class of antibiotics known as cephalosporins. Cefdinir is a third-generation cephalosporin.

2. Upsides

• Treats a wide range of mild-to-moderate infections such as those occurring in the respiratory tract, ear, and on the skin, such as community-acquired pneumonia, acute exacerbations of chronic bronchitis, and sinusitis, tonsillitis, or skin infections.
• Has excellent activity against susceptible gram-positive and gram-negative bacteria, such as Staphylococcus aureus (methicillin-susceptible strains only), Streptococcus pneumoniae (penicillin-susceptible strains only), S. pyogenes, Haemophilus influenzae, H. parainfluenzae, and Moraxella catarrhalis.
• Stable in the presence of some (but not all) beta-lactamase enzymes.
• Available as an oral capsule and an oral powder for suspension.
• May be administered once or twice a day depending on the type of infection.
• May be taken with or without food.
• Generic cefdinir is available.

3. Downsides

If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:

• Diarrhea, rash, and vomiting are the most common side effects. Other side effects may occur but these are generally rare, mild, and resolve with continued therapy.
• Severe diarrhea, caused by the overgrowth of a bacteria called Clostridium difficile, is a potential side effect of almost all antibacterial agents, including cefdinir. Symptoms include persistent, watery, and sometimes bloody diarrhea.
• The dosage of cefdinir may need to be reduced in people with markedly compromised kidney function or who are undergoing hemodialysis. Seizures have been reported when cephalosporins have been used in people with impaired kidney function without a dosage reduction.
• Cross-sensitivity is well documented between cephalosporin and penicillin-type antibiotics. Up to 10% of people who are allergic to penicillin are also allergic to cephalosporins such as cefdinir. Epinephrine and other emergency measures should be on hand if the decision is made to administer cefdinir to a person with a documented penicillin allergy. If a reaction occurs, treat the reaction, discontinue cefdinir, and do not rechallenge.
• May interact with some drugs including aluminum and magnesium-containing antacids, iron supplements or foods fortified with iron, and probenecid.
• Studies in people with liver disease have not been conducted but it is expected that a dosage adjustment is not required in this population.
• May not be suitable for some people including those with kidney disease or colitis. Only effective for certain types of bacterial infection.
• There are no adequate and well-controlled studies in pregnant women. Only use during pregnancy if clearly needed.

Note: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. View complete list of side effects

• Cefdinir is a cephalosporin-type antibiotic effective at treating mild-to-moderate infections caused by susceptible gram-positive and gram-negative bacteria. Side effects are generally mild but may include diarhea, rash, or vomiting.

5. Tips

• Store cefdinir suspension at room temperature (68-77°F [20-25°C]), away from moisture and heat and shake well before each administration. Use a measuring spoon to measure the correct dose. Discard any unused portion after 10 days.
• Do not take if you are allergic to cephalosporin-type antibiotics such as Ceftin, Cefzil, Keflex, and others. Tell your doctor if you are allergic to penicillin, as cross-sensitivity may occur.
• May be taken with or without food.
• Do not take at the same time as antacids containing magnesium or aluminum, or supplements containing iron. Separate administration by at least two hours. Note that iron-fortified formula does not significantly interfere with cefdinir suspension and may be administered at the same time.
• Take cefdinir exactly as prescribed and finish the course to reduce the development of drug-resistant bacteria. Never share your antibiotics with somebody else. Cefdinir only treats bacterial infections, not viral infections.
• See your doctor if you develop prolonged or significant watery or bloody diarrhea while taking cefdinir or within two months of finishing the course.
• People with diabetes should be aware that cefdinir suspension contains 2.86g of sucrose per teaspoon. Cefdinir may also interfere with urine glucose or ketone tests.
• Tell your doctor if you are pregnant or intending to become pregnant before taking cefdinir.

6. Response and effectiveness

• Cefdinir reaches a peak level in the blood within two to four hours of taking an oral capsule.

7. Interactions

Medicines that interact with cefdinir may either decrease its effect, affect how long it works for, increase side effects, or have less of an effect when taken with cefdinir. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Speak to your doctor about how drug interactions should be managed.

Common medications that may interact with cefdinir include:

• antacids containing aluminum or magnesium
• anticoagulants (blood thinners), such as warfarin (may prolong bleeding time)
• estradiol
• iron supplements or foods fortified with iron
• other antibiotics, such as chloramphenicol, sulfonamides, macrolides, and tetracycline
• probenecid
• probiotics, such as Lactobacillus
• vaccinations, such as BCG, cholera, or typhoid vaccine (may diminish the effectiveness)
• vitamins, such as fat-soluble vitamins A, D, E, or K, folate, iron, or zinc (may decrease blood concentrations of cefdinir)
• warfarin.

May cause a false-positive for ketones in the urine with tests that use nitroprusside but not with those using nitroferricyanide. False-positive results for glucose in the urine may also occur with Clinitest, Benedict’s solution, or Fehling’s solution. Use tests that are based on enzymatic glucose oxidase reactions, such as Clinistix or Tes-Tape instead.

Note that this list is not all-inclusive and includes only common medications that may interact with cefdinir. You should refer to the prescribing information for cefdinir for a complete list of interactions.

More about cefdinir

• Check interactions
• Compare alternatives
• Pricing & coupons
• Reviews (382)
• Drug images
• Side effects
• Dosage information
• During pregnancy
• Support group
• Drug class: third generation cephalosporins
• Breastfeeding
• En español

Patient resources

• Drug Information
• Cefdinir (Advanced Reading)
• Cefdinir Capsules
• Cefdinir Suspension

Other brands

Omnicef, Omnicef Omni-Pac

Professional resources

• Prescribing Information

Related treatment guides

• Bacterial Infection
• Otitis Media
• Pneumonia
• Bronchitis

References

• Cefdinir [Package Insert]. Revised 07/2022. Aidarex Pharmaceuticals LLC https://www.drugs.com/pro/cefdinir.html

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use cefdinir only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Copyright 1996-2023 Drugs.com. Revision date: August 28, 2022.

Medical Disclaimer

Rinicef ​​300mg/ Rinicef ​​300mg

Trade name: Rinicef

International Nonproprietary Name: Cefdinir/Cefdinir

Presentation: capsules 300 mg.

Description: hard gelatin capsules, black opaque cap and gray opaque base.

Composition:

1 capsule contains:

active substance : cefdinir – 300. 00 mg;

Pharmacotherapeutic group

Antibacterial agents for systemic use. Third generation cephalosporins. ATX code: J01DD15

Pharmacological properties.

Pharmacodynamics

The active substance cefdinir is a semi-synthetic broad-spectrum cephalosporin antibiotic of the third generation for oral administration. Like other antibiotics of the cephalosporin group, cefdinir has a bactericidal effect against susceptible microorganisms due to the inhibition of the synthesis of peptidoglycan of the bacterial cell wall by disrupting the final stage of transamination necessary for the formation of cross-links. Cefdinir is resistant to many, but not all, beta-lactamases produced by Gram-positive and Gram-negative bacteria. Due to this, many microorganisms resistant to penicillins and some cephalosporins are sensitive to cefdinir. The spectrum of action of cefdinir includes:

Aerobic Gram-positive microorganisms

Staphylococcus aureus (including beta-lactamase producing strains)

Staphylococcus pneumoniae
(only strains sensitive to penicillin)

Staphylococcus pyogenes

Aerobic gram-negative microorganisms

Haemophilus influenzae (including beta-lactamase producing strains)

Haemophilus parainfluenzae
(including beta-lactamase producing strains)

Moraxella catarrhalis (including beta-lactamase producing strains)

The following data was obtained in vitro , but their clinical significance is unknown.

Minimum inhibitory concentration (MIC) of cefdinir in in vitro
is 1 μg / ml or less in relation to (≥ 90%) strains of the following microorganisms; however, the safety and efficacy of cefdinir in the treatment of infections caused by the following microorganisms has not been demonstrated in clinical studies.

Aerobic gram-positive microorganisms

Staphylococcus epidermidis

Streptococcus agalactiae

Streptococcus viridans group

Aerobic gram-negative microorganisms

Citrobacter diversus

Escherichia coli

Klebsiela pneumoniae

Proteus mirabilis

Cefdinir is inactive against strains Pseudomonas, Enterobacter, Enterococcus and methicillin-resistant strains of staphylococci.

Method of administration and dosage

Recommended dosages and duration of treatment for infections in adults and adolescents are described in the table below. The total daily dose for the treatment of all infections is 600 mg. Dosing the drug once a day for 10 days is as effective as taking it twice a day. Once-daily dosing has not been studied for the treatment of pneumonia and skin infections, so Rinicef ​​should be taken twice daily in these cases. The capsules can be taken with or without food.

For the treatment of children (6 months – 12 years), cefdinir is used in the form of a suspension.

Adults and adolescents (ages 13 and over)

Elderly patients: does not require a change in dosing regimen, unless there is a significant impairment of renal function (CC < 30 ml / min). If CC < 30 ml / min, the drug should be taken at a dose of 300 mg once a day.

Patients with renal insufficiency

For patients with CC < 30 ml/min, cefdinir should be given at a dose of 300 mg once daily.

Hemodialysis patients

Hemodialysis promotes the elimination of cefdinir from the body. For patients on permanent hemodialysis, the recommended starting dose is 300 mg or 7 mg/kg every other day. At the end of each hemodialysis session, 300 mg (or 7 mg/kg) of cefdinir is given. Subsequent doses (300 mg or 7 mg/kg) are then given every other day.

If you miss the next dose of the drug, you should take it as soon as you remember. If this missed dose occurs at the time of the next dose, skip the missed dose and follow the previous dosing regimen, do not double the dose.

Side effect

Cefdinir is well tolerated, the identified adverse reactions were mild in nature and resolved spontaneously after discontinuation. Most withdrawals were associated with gastrointestinal disturbances, mainly manifested by diarrhea or nausea. In rare cases, the withdrawal of the drug was due to the development of a rash while taking cefdinir.

Adverse reactions are classified according to the frequency of occurrence: very often (≥ 1/10), often (from ≥ 1/100 to < 1/10), infrequently (from ≥ 1/1,000 to < 1/100), rarely (≥ 1/100). 10,000, <1/1000), very rare (<1/10,000), and the frequency is unknown (frequency cannot be established from the available data).

Very common: diarrhea, rash, nausea.

Often: skin candidiasis, abdominal pain, leukopenia, candidal vaginitis, vaginitis, stool changes, dyspepsia, hyperkinesis, macolopapular rash, nausea, increased AST.

Adverse reactions specific to cephalosporins

Allergic reactions, anaphylaxis, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, renal dysfunction, toxic nephropathy, liver dysfunction including cholestasis, aplastic anemia, hemolytic anemia, hemorrhagic disorders, false positive urine glucose test, neutropenia, pancytopenia and agranulocytosis. Pseudomembranous colitis can develop both during and after the end of the antibiotic prescription.

The use of some cephalosporins was accompanied by the development of seizures, especially in patients with impaired renal function, who were not dose recalculated. If convulsions develop during therapy, the antibiotic should be discontinued. If clinically necessary, anticonvulsant therapy may be prescribed.

According to the results of post-registration experience of use, the following adverse reactions were identified: shock, anaphylaxis (in rare cases with a fatal outcome), edema of the subglottic space and face, feeling of suffocation, serum-like syndrome, conjunctivitis, stomatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, exfoliative dermatitis, erythema multiforme, erythema nodosum, acute hepatitis, cholestatic syndrome, fulminant hepatitis, liver failure, jaundice, increased amylase, acute enterocolitis, hemorrhagic diarrhea, hemorrhagic colitis, melena, pseudomembranous colitis, pancytopenia, granulocytopenia, leukopenia, thrombocytopenia, idiopathic thrombocytopenic purpura, hemolytic anemia, acute respiratory failure, asthma attack, drug-induced pneumonia, eosinophilic pneumonia, idiopathic interstitial pneumonia, fever, acute renal failure, nephropathy, bleeding tendency, bleeding disorder, generalized thrombohemorrhagic syndrome, upper gastrointestinal bleeding, peptic ulcer, intestinal obstruction, loss of consciousness, allergic vasculitis, possible cefdinir-diclofenac interaction, heart failure, chest pain, myocardial infarction, rhabdomyolysis, involuntary movements, hypertension.

In the event of the listed adverse reactions, as well as a reaction not indicated in the instructions for use, you should consult a doctor.

Contraindications

Rinicef ​​is contraindicated in patients with a history of allergy to the cephalosporin class of antibiotics and hypersensitivity to excipients in the composition of the drug.

Overdose

Data on cefdinir overdose in humans are not available.

In acute toxicity studies in rodents, a single oral dose of cefdinir at a dose of 5600 mg/kg did not lead to the development of adverse reactions. The following signs and symptoms of overdose have been observed with other beta-lactam antibiotics: nausea, vomiting, stomach discomfort, diarrhea, and convulsions.

During hemodialysis, cefdinir is removed from the body, which can be useful in case of serious toxic reactions caused by overdose, especially if the patient has impaired renal function.

Precautions

Before starting therapy with Rinicef, it is necessary to exclude the presence of a history of hypersensitivity reactions to penicillins, cephalosporins or other drugs.

In case of suspicion or confirmation of the development of Clostridium difficile -associated diarrhea, antibiotic therapy should be discontinued if it does not work on Clostridium difficile . Based on the clinical condition, the patient may be indicated for fluid replacement, administration of electrolyte and amino acid solutions, antibiotic therapy. Clostridium difficile

Rinicef, like other broad-spectrum antimicrobials (antibiotics), should be used with caution in patients with a history of colitis.

In patients with transient or persistent renal insufficiency (CC <30 ml/min), the daily dose of Rinicef ​​should be reduced, since administration at the recommended doses can lead to a significant increase in plasma concentrations and the half-life of cefdinir.

The administration of cephalosporins can sometimes lead to a positive Coombs test result.

Use during pregnancy and lactation.

Pregnancy and childbirth

Experimental reproduction studies have shown the absence of any teratogenic effect.

Data on the results of the use of cefdinir in pregnant women are not available. Cefdinir should only be used during pregnancy if there is a justified clinical need.

Data on the effect of the appointment of cefdinir on childbirth are not available.

Lactation

When prescribing cefdinir at a dose of 600 mg, it is not detected in breast milk in nursing mothers. Cefdinir is prescribed during lactation only after a careful assessment of the benefit / risk ratio for mother and child.

Influence on the ability to drive vehicles and work with mechanisms.

Rincef does not affect the ability to drive vehicles and work with mechanisms.

Interaction with other drugs

Co-administration of cefdinir and an antacid results in a decrease in the rate (C _max ) and extent (AUC) of cefdinir absorption by approximately 40%. If antacids are required during treatment with Rinicef, Rinicef ​​should be taken at least 2 hours before or 2 hours after taking the antacid.

As with other beta-lactam antibiotics, probenicide interferes with renal excretion of cefdinir when administered concomitantly, resulting in an approximately two-fold increase in AUC, a 54% increase in maximum cefdinir plasma concentration, and a prolongation of the half-life t _1/2 by 50%.

Simultaneous administration of cefdinir with iron-containing drugs containing 60 mg of elemental iron (as FeSO ₄ ) or vitamin drugs containing 10 mg of iron reduces the absorption of cefdinir by 80% and 31%, respectively. If a patient requires iron medications during cefdinir therapy, Rinicef ​​should be taken at least 2 hours before or after taking iron medications.

There have been reports of reddish-colored stools in patients taking cefdinir. In many cases, iron-fortified foods were taken concomitantly by these patients. The reddish coloration may be due to the formation in the gastrointestinal tract of a non-absorbable complex of cefdinir or its degradation products and iron.

During treatment with cefdinir, false-positive results for urinary ketones may occur with nitroprusside, but not with nitroferricyanide. False-positive results may also be noted when determining glucose in the urine using Benedict’s solution or Fehling’s reagent (it is recommended to determine glycosuria only by the enzyme method). The use of cephalosporins can sometimes lead to a positive Coombs test result.

Storage conditions and shelf life

At a temperature not higher than 25°C.

Keep out of the reach of children!

Shelf life 3 years. Do not use after the expiry date stated on the packaging.

Holiday conditions

By prescription.

Packaging

10 capsules in a blister pack made of PVC film and flexible packaging based on aluminum foil.

1 or 2 blister packs, together with the leaflet, are placed in a cardboard pack.

Manufacturer information

Foreign production and trade unitary enterprise “Reb-Pharma”, 223216, Republic of Belarus, Minsk region, Chervensky district, settlement. Smilovichi, st. Sadovaya, 1, tel./fax: (+375) 17 240 26 35, e-mail: [email protected], http://www.rebpharma.by.

Memorial Sloan Kettering Cancer Center

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This document, provided by Lexicomp ^® , contains all the information you need to know about this medicine, including indications, directions for use, side effects, and when your healthcare provider should be contacted.

Trade names: Canada

Omnicef

What is this drug used for?

• It is used to treat various types of bacterial infections.

What should I tell my doctor BEFORE taking this drug?

• If you have an allergy to this drug, any of its ingredients, other drugs, foods or substances. Tell your doctor about your allergies and how they have manifested.

Combining this drug with certain drugs and conditions may be unfavorable.

Tell your doctor and pharmacist about all medicines you take (prescription and over-the-counter, natural products and vitamins) and any health problems you have. You need to make sure that this drug is safe for your conditions and in combination with other drugs you are already taking. Do not start or stop taking any drug or change the dosage without your doctor’s advice.

What do I need to know or do while taking this drug?

• Tell all your health care workers that you are taking this drug. These are doctors, nurses, pharmacists and dentists.
• Do not use beyond the prescribed time. A secondary infection may occur.
• This drug may affect the results of some lab tests. Tell all your health care workers and laboratory staff that you are taking this drug.
• If you have high blood sugar (diabetes) and perform urine glucose tests, talk to your doctor about the best tests to use.
• If you have high blood sugar (diabetes), talk to your doctor. Some of these preparations contain sugar.
• If you take this drug with an iron product, your stool may turn reddish in color. This is fine.
• Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding. The benefits and risks for you and your child will need to be discussed.

What side effects should I report to my doctor immediately?

WARNING. In rare cases, this drug can cause serious and sometimes deadly side effects in some patients. Call your doctor or get medical help right away if you have any of the following signs or symptoms that could be associated with serious side effects:

• Signs of an allergic reaction, such as rash, hives, itching, red and swollen skin with blisters or peeling, possibly accompanied by fever, wheezing or wheezing, tightness in the chest or throat, difficulty breathing, swallowing or speaking, unusual hoarseness, swelling in the mouth, face, lips, tongue or throat.
• Difficulty urinating or a change in the amount of urine produced.
• Dark urine or yellowed skin or eyes.
• Seizures.
• fever, chills, sore throat; the appearance of bruising and bleeding for unexplained reasons; pronounced feeling of tiredness or weakness.
• Diarrhea often occurs when taking antibiotics. In rare cases, severe diarrhea caused by the bacteria Clostridium difficile (C. diff.) [CDAD] may occur. Sometimes this leads to intestinal problems, ending in death. CDAD may occur during or several months after antibiotics are taken. If you experience pain, abdominal cramps, or very loose, watery, or bloody stools, contact your doctor immediately. Check with your doctor before treating diarrhea.

What are some other side effects of this drug?

Any medicine can have side effects. However, for many people, side effects are either minor or non-existent. Contact your doctor or seek medical attention if these or any other side effects bother you or do not go away:

• Diarrhea.

This list of possible side effects is not exhaustive. If you have any questions about side effects, please contact your doctor. Talk to your doctor about side effects.

You can report side effects to the National Health Board.

You can report side effects to the FDA at 1-800-332-1088. You can also report side effects at https://www.fda.gov/medwatch.

What is the best way to take this drug?

Use this drug as directed by your doctor. Read all the information provided to you. Strictly follow all instructions.

All forms:

• Take with or without food. Take with food if medicine causes nausea.
• Use exactly as directed, even if symptoms improve.
• Do not take antacids containing aluminum or magnesium within 2 hours of taking this drug.
• Do not take iron supplements within 2 hours before and 2 hours after taking this drug.

Liquid (suspension):

• Shake well before use.
• Liquid doses should be measured with caution. Use the dispenser that comes with the medication. If the dispenser is not provided in the package, ask the pharmacist for a dosing agent for this drug.
• You can give this drug with iron-containing infant formula.

What if I miss a dose of a drug?

• Take the missed dose as soon as you can.
• If it’s time for your next dose, don’t take the missed dose and then go back to your regular dosing schedule.
• Do not take 2 doses or an additional dose at the same time.

How do I store and/or discard this drug?

Capsules:

• Store at room temperature in a dry place. Do not store in the bathroom.

Liquid (suspension):

• Store the liquid (suspension) at room temperature. Throw away any unused servings after 10 days.
• Store in a dry place. Do not store in the bathroom.

All forms:

• Keep all medicines in a safe place. Keep all medicines out of the reach of children and pets.
• Dispose of unused or expired drugs. Do not empty into a toilet or sewer unless instructed to do so. If you have any questions about disposing of medicines, ask your pharmacist. Drug disposal programs may be in place in your area.

General information about drugs

• If your health does not improve or even worsens, see your doctor.
• Do not give your medicine to anyone and do not take other people’s medicines.
• Some medicines may come with other patient information leaflets. If you have questions about this drug, talk with your doctor, nurse, pharmacist, or other health care professional.
• Some medicines may come with other patient information leaflets. Check with your pharmacist. If you have questions about this drug, talk with your doctor, nurse, pharmacist, or other health care professional.
• If you think you have overdosed, call a poison control center or get medical help right away. Be prepared to tell or show what drug you took, how much, and when it happened.

Consumer Use of Information and Limitation of Liability

This summary information includes a summary of the diagnosis, treatment, and/or drug product. It is not intended to be a comprehensive source of data and should be used as a tool to help the user understand and/or evaluate potential diagnostic and treatment options. It does NOT include all information about conditions, treatments, medications, side effects, or risks that may apply to a particular patient.