What interactions does Xyzal have? How can Xyzal interact with other medications, diseases, and alcohol/food? Explore the comprehensive guide to Xyzal interactions and learn how to manage potential complications.

Understanding Xyzal Interactions: The Comprehensive Guide

Xyzal (levocetirizine) is a popular antihistamine medication used to treat a variety of allergic conditions, including hay fever, hives, and other skin reactions. While Xyzal can be an effective treatment, it’s important to be aware of the potential interactions it may have with other medications, diseases, and even certain food and alcohol consumption.

Xyzal Drug Interactions: The Detailed Report

According to the information provided by Drugs.com, there are a total of 249 known drug interactions with Xyzal. Of these, 1 is classified as major, 246 are moderate, and 2 are minor. Let’s take a closer look at some of the most frequently checked interactions:

Major Interactions

The only major interaction identified is with albuterol, a common asthma medication. These two drugs should be used with caution, as the combination may increase the risk of side effects.

Moderate Interactions

Some of the more common moderate interactions include:

• Aspirin
• Atorvastatin (a cholesterol-lowering medication)
• Benadryl (diphenhydramine)
• Cymbalta (duloxetine)
• Famotidine
• Flonase (fluticasone nasal)
• Gabapentin
• Hydroxyzine
• Ibuprofen
• Levothyroxine (a thyroid medication)
• Lexapro (escitalopram)
• Lisinopril (a blood pressure medication)
• Melatonin
• Metformin (a diabetes medication)
• Montelukast
• Nexium (esomeprazole)
• Omeprazole
• Pantoprazole
• Prednisone
• Singulair (montelukast)
• Synthroid (levothyroxine)
• Tramadol
• Trazodone
• Tylenol (acetaminophen)
• Vitamin B12 (cyanocobalamin)
• Vitamin C (ascorbic acid)
• Vitamin D3 (cholecalciferol)
• Xanax (alprazolam)
• Zyrtec (cetirizine)

These moderate interactions may require dosage adjustments, close monitoring, or even the avoidance of certain combinations, depending on the specific situation and the advice of your healthcare provider.

Minor Interactions

The two minor interactions identified are with aspirin and lisinopril. While these interactions are considered less clinically significant, it’s still important to discuss them with your doctor to ensure the safe and effective use of Xyzal.

Xyzal Alcohol and Food Interactions

In addition to drug interactions, Xyzal also has one known alcohol/food interaction. Specifically, the Drugs.com information indicates that there is one alcohol/food interaction with Xyzal (levocetirizine).

Xyzal Disease Interactions

Xyzal may also interact with certain medical conditions. According to the information provided, there are two disease interactions with Xyzal (levocetirizine):

1. Renal impairment
2. Urinary retention

Patients with these conditions may need to use Xyzal with caution or under the close supervision of their healthcare provider.

Managing Xyzal Interactions: Tips and Strategies

To manage Xyzal interactions effectively, it’s important to:

1. Inform your healthcare provider about all the medications, supplements, and herbal products you are currently taking, as well as any medical conditions you have.
2. Follow the dosage instructions carefully and do not exceed the recommended dose of Xyzal.
3. Avoid consuming alcohol while taking Xyzal, as this can increase the risk of side effects.
4. Monitor for any changes in your condition or the emergence of new symptoms, and report them to your healthcare provider immediately.
5. Work closely with your pharmacist and healthcare provider to identify potential interactions and develop a plan to manage them safely.

By being proactive and communicating openly with your healthcare team, you can help ensure the safe and effective use of Xyzal while minimizing the risks of potential interactions.

Frequently Asked Questions about Xyzal Interactions

Does Xyzal interact with my other medications?

Yes, Xyzal (levocetirizine) can interact with a wide range of medications, including common drugs like aspirin, atorvastatin, and Tylenol. It’s important to review the detailed list of known interactions with your healthcare provider to ensure the safe use of Xyzal.

Can Xyzal interact with my medical conditions?

Yes, Xyzal can interact with certain medical conditions, such as renal impairment and urinary retention. Patients with these conditions may need to use Xyzal with caution or under the close supervision of their healthcare provider.

Does Xyzal interact with alcohol or certain foods?

Yes, Xyzal has one known alcohol/food interaction. It’s recommended to avoid consuming alcohol while taking Xyzal, as this can increase the risk of side effects.

How can I manage Xyzal interactions effectively?

To manage Xyzal interactions effectively, it’s important to inform your healthcare provider about all your medications and medical conditions, follow the dosage instructions carefully, avoid alcohol consumption, and monitor for any changes in your condition. Collaborating closely with your healthcare team is key to ensuring the safe and effective use of Xyzal.

Conclusion

Xyzal (levocetirizine) is a widely used antihistamine medication, but it’s important to be aware of its potential interactions with other drugs, medical conditions, and even alcohol and certain foods. By understanding the comprehensive guide to Xyzal interactions, you can work with your healthcare provider to manage these potential complications and ensure the safe and effective use of this medication.

Xyzal Interactions Checker – Drugs.com

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There are 249 drugs known to interact with
Xyzal (levocetirizine), along with
2 disease interactions, and 1 alcohol/food interaction.

Of the total drug interactions,
1 is major, 246 are moderate, and 2 are minor.

Does Xyzal interact with my other drugs?

Enter other medications to view a detailed report.

• View all 249 medications that may interact with Xyzal
• View Xyzal alcohol/food interactions (1)
• View Xyzal disease interactions (2)

Most frequently checked interactions

View interaction reports for Xyzal (levocetirizine) and the medicines listed below.

• Major
• Moderate
• Minor
• Unknown

• albuterol
• aspirin
• atorvastatin
• Benadryl (diphenhydramine)
• Cymbalta (duloxetine)
• famotidine
• Flonase (fluticasone nasal)
• gabapentin
• hydroxyzine
• ibuprofen
• levothyroxine
• Lexapro (escitalopram)
• lisinopril
• melatonin
• metformin
• montelukast
• Nexium (esomeprazole)
• omeprazole
• pantoprazole
• prednisone
• Singulair (montelukast)
• Synthroid (levothyroxine)
• tramadol
• trazodone
• Tylenol (acetaminophen)
• Vitamin B12 (cyanocobalamin)
• Vitamin C (ascorbic acid)
• Vitamin D3 (cholecalciferol)
• Xanax (alprazolam)
• Zyrtec (cetirizine)

Xyzal alcohol/food interactions

There is 1 alcohol/food interaction with Xyzal (levocetirizine).

Xyzal disease interactions

There are 2 disease interactions with Xyzal (levocetirizine) which include:

• renal impairment
• urinary retention

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More about Xyzal (levocetirizine)

• Xyzal consumer information
• Compare alternatives
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• Reviews (285)
• Drug images
• Side effects
• Dosage information
• During pregnancy
• FDA approval history
• Drug class: antihistamines
• Breastfeeding
• En español

Related treatment guides

• Urticaria
• Allergic Rhinitis
• Allergies

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.

Major	Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate	Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor	Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown	No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Xyzal Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Uses

How to use Xyzal

If you are taking the over-the-counter product to self-treat, read and follow all directions on the product package before taking this medication. If you have any questions, consult your pharmacist. If your doctor has prescribed this medication, take it as directed.

This medication is taken by mouth with or without food, usually once daily in the evening.

If you are using the liquid form of this medication, measure the dose carefully using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.

The dosage is based on your age, medical condition, and response to treatment. Do not increase your dose or take this medication more often than directed.

If your condition does not get better or if it gets worse, or if you think you may have a serious medical problem, get medical help right away.

Side Effects

Drowsiness, tiredness, and dry mouth may occur. Fever or cough may also occur, especially in children. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

If your doctor has directed you to use this medication, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: difficulty urinating, weakness.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking levocetirizine, tell your doctor or pharmacist if you are allergic to it; or to cetirizine; or to hydroxyzine; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: difficulty urinating (such as due to an enlarged prostate), kidney disease.

This drug may make you drowsy. Alcohol or marijuana (cannabis) can make you more drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

Liquid products may contain sugar and/or aspartame. Caution is advised if you have diabetes, phenylketonuria (PKU), or any other condition that requires you to limit/avoid these substances in your diet. Ask your doctor or pharmacist about using this medication safely.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

This medication passes into breast milk. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Tell your doctor or pharmacist if you are taking other products that cause drowsiness such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or other antihistamines (such as diphenhydramine, promethazine).

Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.

Do not use with any other antihistamines applied to the skin (such as diphenhydramine cream, ointment, spray) because increased side effects may occur.

Levocetirizine is very similar to hydroxyzine and cetirizine. Do not use these medications while using levocetirizine.

This medication may interfere with certain laboratory tests (including allergy skin testing), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Does Xyzal interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe drowsiness. In children, mental/mood changes (such as restlessness, agitation) may occur before drowsiness.

Keep all regular medical and lab appointments.

If you are taking this medication on a regular schedule and miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Images

Xyzal 5 mg tablet

Color: whiteShape: ovalImprint: X X

This medicine is a white, oval, scored, tablet imprinted with “X X”.

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Xyzal, Xyzal® and treatment with it | Alergii.com

Product Name:

Xyzal (levocetirizine dihydrochloride).

Formulations: Xyzal

• 5 mg filmirani tablets
• Xyzal 5 mg/ml oral caps, solution
• Xyzal 0.5 mg/ml oral solution.

Xyzal 5 mg/ml containing substances with known action: methyl parahydroxybenzoate, propyl parahydroxybenzoate, propylene glycol.

Xyzal 0.5 mg/ml containing substances with known action: methyl parahydroxybenzoate, propyl parahydroxybenzoate, current maltitol.

Therapeutic indications:

Xyzal e is indicated for the symptomatic treatment of allergic rhinitis (including persistent allergic rhinitis) and urticaria in adults and children over 6 years of age when taken on Xyzal filmirani tablets and over 2 years when taken on Xyzal orally kapoki, solution and Xyzal 0. 5 mg/ml oral solution.

Dosage and start on application:

Xyzal for oral administration and may be administered with or without storage. Ages and children over 6 years of age : Daily recommended dose of 5 mg (1 filmiran tablet Xyzal 5 mg filmiran tablets or 20 caps Xyzal 5 mg/ml oral caps, solution). Children aged 2 to 6 years : The recommended daily dose is 2.5 mg, divided into two doses of 1.25 mg (5 drops two five times a day Xyzal 5 mg/ml orally drops, solution or 2, 5 ml twice a day Xyzal 0.5 mg/ml oral solution). Children aged 6 to 12 years : daily recommended dose is 5 mg (1 filmiran tablet, 20 caps or ). Young men and the kids on the zrast over 12 Godni : Diapore is a post -icing dose E 5 mg (1 filirana pill Xyzal 5 Mg Filiri Tablet, 20 Mg/Ml Peeralni caps, identification or 10 ml xyzal 0.5 mg/ml/mg/ml oral solution). The format of the filmiran is not a tablet, but it was used by a child at an age of under 6 years old, but it is not possible to adapt it to a dose. In pediatric patients with macular damage, the dosage of tryabva and all adapters is individual, depending on the miscarriage of clearance and body weight of the patient. Senile age : These do not imply dosing in patients of senile age, provided that fetal function is normal. Bleeding damage : The frequency of the treatment and its individualization in accordance with the brace function. Black-grain damage : Not all charges for dosing at the patient, only with black-grain damage. In the case of a patient with black-and-grained and bbrechno damage, it was damaged on the dose (upper-mountainly damaged). Duration of treatment : intermittent allergic rhinitis (symptoms, drinking for a little over four days a week or a little over four weeks a year) inconsistent history; The treatment may or may not have already disappeared on the symptom and may be renewed, if the symptoms reappear. If allergic rhinitis persists (symptoms of drinking for more than four days a week or more than four weeks a year), you can prescribe a long-term treatment for the patient before the period of exposure to the allergen.

Contraindications:

hypersensitivity to the active substance or any of the helper substances, hydroxyzine, or piperazine derivatives. Patients with severe malformations and creatinine clearance under 10 ml/min.

Special warnings and warnings Measures for use:

Increased attention to the use of alcohol. Special attention should be paid to patients with predisposing factors for urinary retention, patients with epilepsy and patients at risk of convulsions.

Xyzal 5 mg filmirani tablets:

Patients with rare hereditary problems of galactose intolerance, lactase deficiency or glucose-galactose malabsorption are not allowed to take this medicine. Danny is not enough, for yes, they will support the application for levocetirizine with karmacheta and children at the age of under 2 years.

Xyzal 5 mg/ml oral caps, solution and Xyzal 0.5 mg/ml oral solution:

Methyl parahydroxybenzoate and propyl parahydroxybenzoate may be a predictor of an allergic reaction (probably from a funny type).

Interactions with other medicinal products and other forms of interactions:

Do not test for interactions with levocetirizine. Use with the racemate substance cetirizine has not shown clinically significant adverse interactions (with antipyrine, azithromycin, cimetidine, diazepam, erythromycin, glipizide, ketoconazole, and pseudoephedrine).

Pregnancy and pregnancy:

data limiting data (data collected prospectively from a small amount of 300 cases in pregnancy and pregnancy), which did not show malformation or feto/neonatal toxicity from levocetirizine with a clear causal time zka. Prescribed on the burden of Zhenya tryabva and be with increased attention. Contrary to what yama, the data gave levocetirizine se separation in the carmata, maybe even so, as a result, the cato cetirizine se separation in the coveshkoto mlyako. It is possible to observe an undesirable drug reaction associated with levocetirizine when stored naturally. Prescribed for the care of Zhenya tryabva and be with increased attention.

Efficiency in shofirane and work from the machine:

compare the clinical use of levocetirizine in the wrong dose without disturbing attention, reaction and ability to shofiran and work from the machine. However, some patients may experience drowsiness, faintness, and asthenia when taking levocetirizine. Patients who intend to shofirat, pervert potentially dangerous activities or work from a machine, try and foresee the impact on the medicinal product.

Undesirable drug reactions:

Honors (may be taken up to 1 per 10 souls): dryness in tiredness, headache, screechiness and somnolence. For a list of undesirable reactions, please refer to a summary of the characteristics of the drug product. Without a prescription.

Date of last CCP approval:

Xyzal 5 mg filmirani tablets and Xyzal 5 mg/ml oral caps, solution: 28 January 2021.
Xyzal 0.5mg/ml oral solution: 27 May 2021.

Antihistamines in the practice of a dermatologist

Many skin diseases are accompanied by intense itching. Itching is transmitted predominantly along unmyelinated, slowly conducting C-fibers to the central nervous system and is caused by mechanical, thermal, electrical, or chemical stimulation of polymodal C-nerve fibers. The free nerve endings of these fibers at the border of the epidermis and dermis perform the functions of nociceptors directly or indirectly, by releasing various mediators [1].

Substances that cause itching, mediators of itching include biological amines (histamine, serotonin), proteases (exogenous papain, kallikrein, trypsin), peptides (bradykinin, secretin) and neuropeptides (substance P, vasoactive intestinal polypeptide), thyroid hormone – calcitonin , as well as metabolites of arachidonic acid, interleukin-2, growth factors and other biologically active substances [2, 3]. Itching causes not only discomfort, but also insomnia, increased irritability, which in turn significantly reduces the quality of life of the patient.

As a rule, the pathogenesis of diseases accompanied by itching is based on an allergic component. Generally recognized in the treatment of these diseases are antihistamines. However, most of them have a sedative side effect. In recent years, long-acting antihistamines have appeared, in which the sedative effect is weak or completely absent. One such drug is levocetirizine.

Levocetirizine 5 mg (Xyzal, UCB Pharma) – highly selective H 9 inhibitor0118 1 receptor of a new generation, is a pharmacologically active R-enantiomer of the racemate cetirizine (Zyrtec). In clinical studies of inhibitors of the H ₁ receptor, levocetirizine demonstrated an affinity for the H ₁ receptor 2 times higher than that of cetirizine and 30 times higher than the S-enantiomer of dextrocetirizine [4].

Levocetirizine is separated from the H ₁ receptor much more slowly than the S enantiomer [5]. In addition, levocetirizine has a 600-fold higher selectivity for H ₁ -receptor than to H ₂ -, H ₃ -, α- and β-adrenergic receptors, 5HT _1A – and 5HT ₂ -, dopamine _D2 -, adenosine _A1 – and muscarinic receptors [5, 6].

After oral administration, the drug is rapidly and completely absorbed from the gastrointestinal tract. Its relative bioavailability is about 100%. The maximum plasma level is reached 0.9 hours after ingestion. Levocetirizine has a very low volume of distribution of 0.4 L/kg.

In small amounts (less than 14%), levocetirizine is metabolized in the body by N- and O-dealkylation (unlike other H ₁ -histamine receptor antagonists, which are metabolized in the liver using the cytochrome system) with the formation of a pharmacologically inactive metabolite. Due to the low metabolic rate and the lack of metabolic potential, the interaction of levocetirizine with other drugs is unlikely.

The half-life is 7.9 ± 1.9 hours. At least 85% of the drug is excreted by the kidneys, mainly in an unchanged state.

Along with antihistamines, levocetirizine has anti-inflammatory properties in vitro and in vivo [7].

When performing a skin test with levocetirizine at a daily therapeutic dose and in vivo, significant inhibition of sVCAM-1 expression and migration of eosinophilic granulocytes to the area of ​​allergic inflammation was noted compared with placebo [8].

An open-label, multicentre, polyclinic study conducted in Germany examined the clinical efficacy and tolerability of the selective peripheral h2 receptor antagonist levocetirizine in 17,638 patients with allergic respiratory and skin diseases. The mean age of the patients was 38.1±16.0 years [9]. Of these, 14,319 patients suffered from allergic respiratory diseases, 4,704 from allergic skin diseases. The duration of the observation period averaged 32 days, during which patients received 5 mg of levocetirizine daily. Changes in clinical symptoms were documented at the start and end of treatment.

Itching, blistering, redness and eczematous phenomena were observed on the part of the skin. At the end of treatment, a complete disappearance or a significant decrease in the severity of allergic symptoms from the respiratory tract, eyes and skin was recorded in an average of 80-90% of patients. The overall efficacy of levocetirizine in 86.9% of cases was rated from “very good” to “good”.

In 82.8% of patients, the effect occurred quickly – within 60 minutes.

Thus, when observing a large number of patients, it was found that levocetirizine at a daily dose of 5 mg is well tolerated, effectively and quickly reduces the severity of symptoms in patients with allergic skin diseases.

Allergic skin disease was diagnosed in 4704 (26.7%) patients. The same patient was allowed to have several diseases.

Chronic urticaria was registered in 2707 (15.3%) patients. 2180 (12.4%) had another allergic skin disease. These included 591 (3.4%) patients with eczema and 370 (2.1%) with neurodermatitis.

Treatment lasted an average of 31.9±18.3 days. In patients with allergic skin diseases, the duration of the observation phase was somewhat longer and amounted to 35.6±20.4 days.

Skin itch, rash, redness, eczematous phenomena were assessed for skin lesions. The assessment was carried out on the basis of a 4-step scale of severity (no complaints, mild, moderate and severe severity).

At the beginning of treatment, 81.9% of patients noted severe to moderate itching, which is the leading symptom of many allergic skin diseases. At the interim examination, this indicator was 26.5%, and at the final – 10.9%. Comparable results were observed for symptoms such as rash, redness and eczema, which were noted at the beginning of treatment in 49.6%, 59.4% and 28.8% of patients, respectively, with severity from severe to moderate. During the interim survey, these figures decreased to 13.0, 15.3 and 11.5%, respectively, and at the final survey they amounted to 5.8, 7.1 and 5.4%.

The results of this study confirm the relevance of the problem of itching in patients with allergic skin diseases and the need for the correct choice of an antihistamine drug with proven efficacy and a high safety profile.

In addition, there is a need for local research on this issue with the involvement of leading medical centers.

Studies conducted in Moscow on the basis of the KVD hospital No. 15 (2010-2011) included 317 patients aged 18 to 75 years who received levocetirizine as an antihistamine (Fig. 1). Figure 1. Distribution patients under our supervision, according to diagnoses.

1st group consisted of 279patients suffering from chronic eczema. Upon admission to the hospital, all patients in the lesions had pronounced papulovesicular rashes, swelling, weeping. Patients were disturbed by severe itching, multiple excoriations and crusts were noted on the skin. As an antihistamine drug, levocetirizine at a dose of 5 mg 1 time per day was included in the complex therapy; Patients with severe sleep disturbance (39.8% of cases) were prescribed hifenidin or mebhydrolin per os or intramuscularly clemastine at night for the first 3-5 days.

On the 4th-5th day of therapy, there was a decrease in itching and the absence of fresh rashes. Treatment with levocetirizine was carried out for 14-21 days, depending on the severity and prevalence of the process. A 10-point scale was used to assess the severity of clinical symptoms. Subjective sensations such as itching were assessed by patients on this scale. Edema, infiltration and erythema were assessed by a doctor (0 points – no symptoms, 1-3 points – mildly expressed, 4-6 points – moderately expressed, 7-10 points – strongly expressed). At the end of levocetirizine therapy, patients noted a longer remission than after previous courses of treatment when 1st generation antihistamines were used (Fig. 2).

The 2nd group included 8 patients with urticaria, a common disease characterized by the appearance of itchy urticarial elements of different sizes and shapes, rising above the surface of the skin. Any parts of the skin and mucous membranes can be involved in the pathological process. There are several varieties of hives. Acute urticaria lasts up to 6 weeks and is manifested by a sudden onset, severe itching and the presence of blisters of bright pink or pale red color, round or elongated. As a rule, blisters disappear without a trace after a few hours or days. Sometimes there is a fusion of blisters into large areas and a violation of the general condition of the body with fever, weakness, and a decrease in blood pressure. Chronic recurrent urticaria develops against the background of prolonged sensitization caused by foci of chronic infection or dysfunction of internal organs, and lasts more than 6 weeks. With chronic urticaria, the formation of papules is possible. Relapses of the disease are replaced by remissions of different duration. Often, in the same patient, urticarial rashes occur under the influence of different provoking factors. In about half of the patients, urticaria is combined with Quincke’s edema.

Patients with acute urticaria took oral levocetirizine at a dose of 5 mg daily once a day for 2 weeks, and with chronic recurrent urticaria – for 3 weeks. In patients with acute urticaria, the 3-day use of levocetirizine led to the cessation of the appearance of fresh rashes, the cessation of itching was noted on the 3rd–4th day of taking the drug, and complete regression of symptoms occurred after 10 days of treatment. In patients with chronic recurrent urticaria, while taking the drug at the same dose for 3 weeks, there was a decrease in itching on the 4th-5th day, and the cessation of the appearance of fresh rashes on the 7th-8th day. Fresh urticarial elements that appeared while taking levocetirizine were not accompanied by itching and were characterized by less swelling and size. During the 3-month follow-up period at the end of the course of treatment in patients with chronic recurrent urticaria, no exacerbation of the disease was registered.

The 3rd group consisted of 30 patients who were in the hospital with a diagnosis of toxidermia and allergic dermatitis. 21 of them had a bullous form of toxidermia, 9 had allergic dermatitis. There were multiple polymorphic rashes: spotty-vesicular and vesiculo-bullous, accompanied by severe itching. Levocetirizine was prescribed 5 mg once a day for 14 days. In case of sleep disturbance and intense itching, patients were intramuscularly injected at night with 1st generation antihistamines (chloropyramine hydrochloride or clemastine for the first 3 days of therapy).