Vaginal Candidiasis | Fungal Diseases

About

Candidiasis is an infection caused by a yeast (a type of fungus) called Candida. Candida normally lives on skin and inside the body such as in the mouth, throat, gut, and vagina, without causing any problems. Candida can cause an infection if conditions change inside the vagina to encourage its growth. Things like hormones, medicines, or changes in the immune system can make infection more likely. The common term for candidiasis in the vagina is a vaginal yeast infection. Other names for this infection are vaginal candidiasis, vulvovaginal candidiasis, or candidal vaginitis.

Symptoms

The symptoms of vaginal candidiasis include:^1,2

• Vaginal itching or soreness
• Pain during sexual intercourse
• Pain or discomfort when urinating
• Abnormal vaginal discharge

Vaginal candidiasis is often mild. However, some women can develop severe infections involving redness, swelling, and cracks in the wall of the vagina.

Contact your healthcare provider if you have any of these symptoms. These symptoms are similar to those of other types of vaginal infections. A healthcare provider can tell you if you have vaginal candidiasis and how to treat it.

Risk & Prevention

Who gets vaginal candidiasis?

Vaginal candidiasis is common. Women who are more likely to get vaginal candidiasis include those who:

• Are pregnant
• Use hormonal contraceptives (for example, birth control pills)
• Have diabetes
• Have a weakened immune system (for example, due to HIV infection or medicines such as steroids and chemotherapy)
• Are taking or have recently taken antibiotics

How can I prevent vaginal candidiasis?

Wearing cotton underwear might help reduce the chances of getting a yeast infection.² Because taking antibiotics can lead to vaginal candidiasis, take these medicines only when prescribed and exactly as your healthcare provider tells you. Learn more about when antibiotics work and when you do not need them.

Sources

Scientists estimate that about 20% of women normally have Candida in the vagina without having any symptoms.²Candida can cause an infection if the conditions change inside the vagina to encourage its growth. Infection can happen because of hormones, medicines, or changes in the immune system.

Diagnosis & Testing

Healthcare providers usually diagnose vaginal candidiasis by taking a small sample of vaginal discharge. They examine the sample under a microscope in the medical office or send it to a laboratory for a fungal culture. However, a positive fungal culture does not always mean that Candida is causing symptoms. Some women can have Candida in the vagina without having any symptoms.

Treatment

If you have vaginal candidiasis, likely you will use antifungal medicine to treat it.³ Often, the treatment is an antifungal medicine applied inside the vagina or a single dose of fluconazole taken by mouth. You may need other treatments if your infection is:

• Is more severe
• Doesn’t get better
• Keeps coming back after getting better

These treatments include:

• More doses of fluconazole taken by mouth
• Other medicines applied inside the vagina, such as boric acid, nystatin, or flucytosine

If you are a healthcare provider, please refer to:

• The Infectious Diseases Society of America’s Clinical Practice Guidelines for the Management of Candidiasis
• CDC – 2021 Sexually Transmitted Infections Treatment Guidelines: Vulvovaginal Candidiasis

Statistics

Vaginal candidiasis is common. In the United States, it is the second most common type of vaginal infection after bacterial vaginal infections.² An estimated 1.4 million outpatient visits for vaginal candidiasis occur annually.⁴ The number of vaginal candidiasis cases is unknown.

• CDC – 2021 Sexually Transmitted Infections Treatment Guidelines: Vulvovaginal Candidiasis

1. Gonçalves B, Ferreira C, Alves CT, Henriques M, Azeredo J, Silva S. Vulvovaginal candidiasis: epidemiology, microbiology and risk factors. Criti Rev Microbiol 2016;42:905-27.
2. Sobel JD. Vulvovaginal candidosis. Lancet 2007;369:1961-71.
3. Pappas PG, Kauffman CA, Andes DR, Clark CJ, Marr KA, Ostrosky-Zeichner L, et al. Clinical practice guideline for the management of candidiasis: 2016 update by the Infectious Diseases Society of America. Clin Infect Dis 2016;62:e1-50.
4. Benedict K, Jackson BR, Chiller T, Beer KD. Estimation of direct healthcare costs of fungal diseases in the United States. Clin Infect Dis. 2018 Sep 10.

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Candida infections of the mouth, throat, and esophagus | Fungal Diseases

About

Candidiasis is an infection caused by a yeast (a type of fungus) called Candida. Candida normally lives on the skin and inside the body, in places such as the mouth, throat, gut, and vagina, without causing any problems.¹ Sometimes, Candida can multiply and cause an infection if the environment inside the mouth, throat, or esophagus changes in a way that encourages fungal growth.

Candidiasis in the mouth and throat is also called thrush or oropharyngeal candidiasis. Candidiasis in the esophagus (the tube that connects the throat to the stomach) is called esophageal candidiasis or Candida esophagitis. Esophageal candidiasis is one of the most common infections in people living with HIV/AIDS.²

Symptoms

Candidiasis in the mouth and throat can have many different symptoms, including:

• White patches on the inner cheeks, tongue, roof of the mouth, and throat (photo showing candidiasis in the mouth)
• Redness or soreness
• Cotton-like feeling in the mouth
• Loss of taste
• Pain while eating or swallowing
• Cracking and redness at the corners of the mouth

Symptoms of candidiasis in the esophagus usually include pain when swallowing and difficulty swallowing.

Contact your healthcare provider if you have symptoms that you think are related to candidiasis in the mouth, throat, or esophagus.

Risk and Prevention

Who gets candidiasis in the mouth or throat?

Candidiasis in the mouth, throat, or esophagus is uncommon in healthy adults. People who are at higher risk for getting candidiasis in the mouth and throat include babies, especially those younger than 1 month of age, and people with at least one of these factors:^3-7

• Wear dentures
• Have diabetes
• Have cancer
• Have HIV/AIDS
• Take antibiotics or corticosteroids, including inhaled corticosteroids for conditions like asthma
• Take medications that cause dry mouth or have medical conditions that cause dry mouth
• Smoke

Most people who get candidiasis in the esophagus have weakened immune systems, meaning that their bodies don’t fight infections well. This includes people living with HIV/AIDS and people who have blood cancers such as leukemia and lymphoma. People who get candidiasis in the esophagus often also have candidiasis in the mouth and throat.

How can I prevent candidiasis in the mouth or throat?

Ways to help prevent candidiasis in the mouth and throat include:

• Maintain good oral health
• Rinse your mouth or brush your teeth after using inhaled corticosteroids

Sources

Candida normally lives in the mouth, throat, and the rest of the digestive tract without causing any problems. Sometimes, Candida can multiply and cause an infection if the environment inside the mouth, throat, or esophagus changes in a way that encourages its growth.

This can happen when:

• a person’s immune system becomes weakened,
• if antibiotics affect the natural balance of microbes in the body,
• or for a variety of other reasons in other groups of people.

Diagnosis and Testing

Healthcare providers can usually diagnose candidiasis in the mouth or throat simply by looking inside.⁸ Sometimes a healthcare provider will take a small sample from the mouth or throat. The sample is sent to a laboratory for testing, usually to be examined under a microscope.

Healthcare providers usually diagnose candidiasis in the esophagus by doing an endoscopy. An endoscopy is a procedure to examine the digestive tract using a tube with a light and a camera. A healthcare provider might prescribe antifungal medicine without doing an endoscopy to see if the patient’s symptoms get better.

Treatment

Candidiasis in the mouth, throat, or esophagus is usually treated with antifungal medicine.⁶ The treatment for mild to moderate infections in the mouth or throat is usually an antifungal medicine applied to the inside of the mouth for 7 to 14 days. These medications include clotrimazole, miconazole, or nystatin. For severe infections, the most common treatment is fluconazole (an antifungal medication) taken by mouth or through a vein. If patient does not get better after taking fluconazole, healthcare providers may prescribe a different antifungal. The treatment for candidiasis in the esophagus is usually fluconazole. Other types of prescription antifungal medicines can also be used for people who can’t take fluconazole or who don’t get better after taking fluconazole.

If you are a healthcare provider, click here to see the Infectious Diseases Society of America’s Clinical Practice Guidelines for the Management of CandidiasisExternalexternal icon.

Statistics

The exact number of cases of candidiasis in the mouth, throat, and esophagus in the United States is difficult to determine. This is because there is no national surveillance for these infections. The risk of these infections varies based on the presence of certain underlying medical conditions. For example, candidiasis in the mouth, throat, or esophagus is uncommon in healthy adults. However, they are some of the most common infections in people living with HIV/AIDS.² In one study, about one-third of patients with advanced HIV infection had candidiasis in the mouth and throat. ⁹

Vulvovaginal candidiasis | Dikul Center

Vulvovaginal candidiasis is a fungal infection that causes irritation, discharge, and severe itching in the vagina and vulva, the tissues at the entrance to the vagina.

Vaginal yeast infection develops in up to 70% of women during their lifetime, and many of these episodes may occur several times.

Vaginal candidiasis is not a sexually transmitted infection. But the first regular sex life significantly increases the risk of developing candidiasis. Also, candidiasis can be associated with oral-genital sex.

Vaginal yeast infections respond well to treatment. In the presence of recurrent yeast infection – four or more times during the year – the patient may need long-term maintenance therapy.

Symptoms

Symptoms of candidiasis can range from mild to moderate and include:

• Feelings of itching and irritation in the vagina and vulva
• Burning sensation when urinating or during intercourse.
• Redness and swelling of the vulva
• Vaginal pain and tenderness
• Vaginal rash
• Odourless thick white cheesy vaginal discharge.
• Watery vaginal discharge

Complicated candidiasis

A woman may have a yeast infection if:

• There are severe symptoms such as extensive redness, swelling, and itching that are complicated by tears, cracks, or sores.
• If yeast infection develops more than four times a year
• Infection due to an atypical fungus
• Pregnancy
• Uncontrolled diabetes
• Weakening of the immune system due to the use of certain medications or the presence of serious diseases such as HIV infection.

When to see a doctor?

You need to make an appointment with a doctor if:

• Symptoms of a yeast infection appear for the first time
• It is doubtful that this is a fungal infection
• Symptoms do not improve after taking over-the-counter antifungal vaginal creams or suppositories.
• Other symptoms appear

Causes

Candida albicans is the main cause of most vaginal yeast infections.

The vagina is known to naturally contain a balanced mixture of yeast, including Candida, and bacteria. Some bacteria (lactobacilli) prevent yeast from growing.

But this balance can be upset. Overgrowth of fungi or their penetration into the deeper layers of the mucous tissue of the vagina can lead to the development of symptoms of a yeast infection.

Yeast overgrowth can be caused by:

• The use of antibiotics, which can upset the balance of the natural vaginal flora
• Pregnancy
• Uncontrolled diabetes
• Immune system disorders
• Taking contraceptives or hormone therapy, which can increase the level of estrogen in the blood.

Candida albicans is the most common type of fungus that causes yeast infections. Yeast infections caused by other types of Candida are much more difficult to treat and usually require more aggressive treatments.

Risk factors

Factors that increase the risk of fungal infection include:

• Taking antibiotics. A yeast infection is not uncommon in women who take antibiotics. Broad-spectrum antibiotics kill not only a number of bacteria, but also the normal microflora in the vagina, which can cause yeast overgrowth.
• Increased estrogen levels contribute to the development of yeast infections. This can be both pregnant women and women who use high-dose estrogen birth control pills or if estrogen hormone therapy is being performed.
• Uncontrolled diabetes. Women with poor control and high blood sugar levels are more at risk of developing fungal infections than women who control their blood sugar levels.
• Immune system disorders. Women who are immunosuppressed, such as after corticosteroid therapy or HIV infection, are more at risk of yeast infections.

Prevention

To reduce the risk of vaginal yeast infections, it is recommended to wear underwear that is not too tight with a cotton gusset.

Also recommended:

• Do not use tight fitting tights
• Douche as this flushes out some of the normal bacteria in the vagina that protect against infection.
• Use scented products for women frequently, such as bubble baths, pads, and tampons.
• Very hot and whirlpool baths are not recommended
• Do not take antibiotics unnecessarily, such as for colds or other viral infections.
• Avoid prolonged exposure to wet clothing such as swimwear and sportswear.

Diagnosis

To diagnose thrush, the doctor can:

• Ask questions about symptoms and medical history. It is important for the physician to collect information about past vaginal or sexually transmitted infections.
• Perform a gynecological examination. The doctor will examine the external genitalia to look for signs of a fungal infection. Then the doctor will examine the vagina and cervix using a special speculum.
• Collect vaginal secretions. The doctor may send a sample of vaginal fluid for analysis to determine the type of fungus that caused the yeast infection. Identifying the fungus can help your doctor decide on the appropriate treatment, especially if you have recurrent yeast infections.

Treatment

Treatment for yeast infections depends on the severity and frequency of infections.

For mild to moderate symptoms and infrequent episodes, your doctor may recommend:

• Short-term vaginal therapy. Taking antifungal medications for three to seven days usually clears up the yeast infection. Antifungal drugs, in the form of creams, ointments, tablets and suppositories, include miconazole (monistat 3) and terconazole. Some of these medicines can be purchased without a prescription, while others are available by prescription only.
• Single oral dose. Your doctor may prescribe a single oral dose of fluconazole (Diflucan). But taking such drugs is contraindicated during pregnancy. In the presence of severe symptoms, it is possible to take two single doses with an interval of three days.

Seek medical attention again if treatment does not relieve symptoms or if symptoms return within two months.

If you have severe symptoms or have frequent yeast infections, your doctor may recommend:

• Long-term vaginal therapy. Your doctor may prescribe antifungal medications taken daily for two weeks and then once a week for six months.
• Multi-dose oral preparation. Your doctor may prescribe two or three doses of an oral antifungal instead of vaginal therapy. However, this treatment is not recommended for pregnant women.
• Azol-resistant therapy. A doctor may recommend boric acid capsules to be inserted into the vagina. This medication should not be taken orally as it is toxic and is only used to treat Candida that is resistant to conventional antifungals.
• Correction of the underlying disease, such as diabetes or immunodeficiency, to avoid relapses.

Yeast infections: diseases, treatment and preparations

Where can I buy?

Encyclopedia

Fungus

Skin and/or mucous membrane lesions caused by yeast fungi are called yeast infections.

The author of the article

Moshkova Elena Mikhailovna

Dermatovenereologist, head of the KDO for the provision of paid services, St. Petersburg State Budgetary Institution of Health “City Dermatovenerologic Dispensary”, St. Petersburg.

What yeast-like fungi cause diseases in humans

Both bacteria and fungal microorganisms normally live on human skin. In small quantities, they are part of the normal microflora of the skin. Yeasts and yeast-like fungi can also live on the skin without causing any skin disease. However, if adverse factors occur (decreased immunity, impaired microflora), fungi begin to actively multiply, their number increases and leads to the development of the disease.

How is skin fungus treated? Watch in a two-minute video with Doctor of Medical Sciences, Professor of the Russian Academy of Sciences Olga Borisovna Tamrazova

Fungi of the genus Malassezia

Yeast-like fungi of the genus Malassezia – the cause of skin dermatosis: seborrheic dermatitis and versicolor (pityriasis) versicolor 90 186 . Approximately 20% of people experience occasional cases of seborrheic dermatitis. And 10% of the population suffers from multicolored (pityriasis) lichen ³ .

Fungi of the genus Candida

Yeast fungi of the genus Candida – causative agents of candidiasis of the skin, mucous membranes and internal organs. Fungi of the genus Candida are conditionally pathogenic microorganisms, for the existence of which the presence of oxygen in the environment is an optional condition. This explains the possibility of candidiasis of internal organs.

Up to 30-50% of the population carry Candida on their skin. This type of fungus can colonize the mucous membrane of the mouth, intestines, and the genitourinary system.

How fungi of the genus Candida affect human health

Cause itching and dry skin

Provoke the appearance of a white coating on the tongue and bad breath

Contribute to vaginal candidiasis

Affect the feet

900 02 Of the 150 existing species of Candida, 20 species are the causative agents of candidiasis. Most often, Candida albicans, C.tropicalis, C.parapsilosis, C.glabrata ¹ are found in patients.

Skin may show C. albicans, C. parapsilosis, C. guillermondii, C. kefyr ¹ . However, skin candidiasis usually develops due to the presence of Candida albicans , other types of Candida cause skin lesions much less ¹ .

The cause of candidiasis of the genitourinary system in almost 90% of people is C. albicans, in 10% – C. krusei, C. glabrata and others ¹ .

Locations of yeast infections. Symptoms

Seborrheic dermatitis

Seborrheic dermatitis most often occurs on the face and scalp. But the process can be widespread and localized in other seborrheic areas of the body (skin of the back, chest). Rashes are represented by pink spots with peeling on the surface. Sometimes the inflammation is so severe that itching and excessive moisture of the skin (weeping) appear. Often the only manifestation of seborrheic dermatitis is dandruff.

Pityriasis versicolor (pityriasis)

With versicolor versicolor, there is no skin inflammation, so patients are only concerned about the aesthetic component of dermatosis. Spots up to 1 cm usually appear on parts of the body with excessive sweating. The color of the rashes can vary from beige to pink, over time the spots merge into large foci.

Candidiasis of the skin and oral mucosa

Candidiasis of the skin often occurs in the interdigital, axillary, inguinal folds, on the skin under the mammary glands, and in the fold of the abdomen.

Large fold candidiasis

Large fold candidiasis Doctors also call Candida intertrigo ² . At the bottom of the fold, small bubbles appear, which open up, exposing bright pink with a bluish tinge of skin erosion. Over time, defects in the upper layer of the skin increase in size, merge and can completely spread to the entire surface of a large fold. The erosive surface is wet with a lacquer sheen. A whitish coating may be present. On the periphery of candidal foci, screenings can be found – islands of skin with small vesicles, pustules or small erosions.

Candidiasis of the interdigital folds of the hands often occurs in housewives, catering workers. The predisposing factor is constant contact with water. Often only one interdigital fold on the “working” hand is affected. There is redness, itching, there may be cracks.

Smooth skin candidiasis

Smooth skin candidiasis is more often a complication of an underlying dermatological disease, such as atopic dermatitis or due to the spread of a fungal infection from the skin of large folds.

Candidiasis of the nail folds and nails

Redness, swelling, pain appear at the site of the fungus penetration into the skin of the periungual fold. When pressing on the periungual roller, there are no purulent compartments, in contrast to inflammation of a bacterial nature. And brownish transverse grooves appear on the nail plate, the nail thickens, loses its luster.

Urogenital candidiasis

This disease does not apply to sexually transmitted infections ² .

In men, candidal balanitis, balanoposthitis and urethritis are more common.

Men report the following symptoms: ³

• Redness, whitish coating, swelling, itching, burning in the area of ​​the glans penis
• Painful urination and intercourse

See how thrush is treated in a short video by Professor, Doctor of Medical Sciences, Evgenia Valerievna Shikh

Vulvovaginal candidiasis (thrush) occurs in women – Candida fungi damage the mucous membrane of the external genitalia and vagina.

More than 70% of women have had an episode of urogenital candidiasis at least once in their lives. And 15% of them had repeated episodes of this disease ³ .

Women note: ³

• White cheesy discharge from the genital tract
• Itching, burning
• Painful urination and intercourse

Predisposing factors for yeast infections

Predisposing factors for yeast infections: ³

• Long-term antibiotic therapy
• Taking anticancer drugs (cytostatics)
• Uncompensated diabetes mellitus
• Immunodeficiency
• Hormonal disorders

Predisposing factors for skin candidiasis include: prolonged contact with water, skin abrasions, excess weight. For the development of oral candidiasis – traumatization of the mucous membrane, for example, when wearing dentures, braces.

Diagnosis of yeast infections

Diagnosis of skin candidiasis is based on the clinical picture of the disease. The doctor may additionally prescribe a skin scraping test for the presence of Candida fungi.

In the diagnosis of urogenital candidiasis, great importance is given to microscopic and cultural methods with the determination of the type of fungus of the genus Candida and its sensitivity to antifungal drugs ³ . And with the help of special test systems, you can detect DNA fragments of the causative agent of urogenital candidiasis.

Diagnosis of diseases caused by fungi of the genus Malassezia is based on the examination of skin manifestations, dermatoscopy, the study of skin scrapings for fungi, the definition of the Benier phenomenon (peeling of the rash when scraped with a fingernail or spatula) and the Balzer test (5% alcohol solution of iodine is applied to the affected area with the capture of healthy skin. Increased staining of the rash compared to areas of healthy skin indicates the presence of fungi of the genus Malassezia).

Treatment of yeast infections

Treatment of candidiasis of the skin consists of:

1) Use of topical antifungals in the form of cream/ointment, solution, spray

2) Eliminate the source of the pathogen in the intestines or genitourinary tract, this is prescribed antifungal drugs for oral administration

9 0002 3) Elimination or correction of provoking factors

Treatment of urogenital candidiasis consists of:

1) Prescription of antifungal drugs for oral and local use0003

2) Prescription of anti-allergic drugs

3) Vitamin therapy

(In some cases, immunomodulatory drugs are recommended)

, creams, ointments), and for oral administration (tablets, capsules). Most often, it is possible to solve the problem with external antifungal agents. However, with widespread rashes, severe persistent course, drugs are prescribed for oral administration

The use of antiseptic or antibacterial drugs when a bacterial infection attaches to weeping areas of the skin antifungal medicines: sertaconazole, clotrimazole, ketoconazole, terbinafine. For example, appointment Zalain ^® cream 2% (sertaconazole) promotes healing better than other drugs (versus clotrimazole) ⁵ .

Sertaconazole-based cream (Zalain®) for yeast infections

Sertaconazole-based products (Zalain ^® ) are available in the form of suppositories and cream.

When Zalain ^® cream is applied topically for two weeks, the components of the drug are not detected in the blood and urine, which indicates a high drug safety profile ⁷ .

Sertaconazole has a triple action: it prevents the growth and reproduction of fungi, promotes their death, and also prevents the transition of fungi from a passive form to a pathogenic one (only for fungi of the genus Candida) ¹⁵ .

Instruction

Zalain ^® Yeast Infection Cream

How to use Zalain Cream ^®

For skin candidiasis, seborrheic dermatitis, pityriasis versicolor Zalain ^® cream is applied 2 times a day in a thin layer covering healthy skin for 2-4 weeks ⁶ .

Topical and systemic antifungal therapy may be indicated for the treatment of urogenital candidiasis.

Urogenital candidiasis in men can be treated externally:

• Zalain ^® cream is applied 2 times a day in a thin layer for 14 days ⁶ .

Has a triple effect: antifungal, antipruritic, anti-inflammatory

Used 1-2 times a day

Where to buy Zalain ^® Cream for the treatment of yeast infections

or

Find the nearest pharmacy

Zalain ^® Suppositories

Sertaconazole-based cream (Zalain ^® ) for the treatment of fungal infections al tablets or suppositories (suppositories).

Doctors also recommend vaginal suppositories based on sertaconazole (Zalain ^® ). One suppository is inserted into the vagina 1 time. The use of 1 vaginal suppository is explained by the fact that sertaconazole has a high lipophilicity – it dissolves well in lipid (fat) cell structures. Due to this, the drug remains in the vaginal mucosa for a long time (7 days) at a therapeutic concentration, having a triple mechanism of action on Candida fungi. For women, this prescription of the drug is very convenient.

Unlike other drugs for the treatment of urogenital candidiasis, the effect of Zalain ^® suppositories is observed with a single application of ⁷ . If necessary (maintenance of clinical symptoms), treatment can be repeated after 1 week ⁷ . The doctor may recommend Zalain ^® suppositories to pregnant women if necessary.

The use of specially adapted intimate hygiene gels helps maintain a healthy microflora of the vulva and resist infections.

Only 1 suppository per course

Local effect of the drug

No absorption of sertaconazole into the bloodstream ¹³

Can be used during pregnancy and lactation *

Where to buy Zalain ^® Candles

Instruction

Why is 1 candle valid for 7 days?

Zalagel ^® Intim

Antiseptic properties of components Zalagel ^® Intim

Zalagel ^® Intim gel-soap, gently cleanses the skin of the intimate area, has a calming effect ohm and helps to reduce the feeling of discomfort.

U Zalagel ^® Intim Slightly alkaline pH (8-9), creating a destructive environment for fungi of the genus Candida (causative agents of thrush). The betaine component, which is part of the gel, prevents dryness of the intimate area, maintains the physiological balance of the skin and mucous membranes.

Gently cleanses the intimate area

Creates a destructive environment for fungi of the Candida genus

Protects the female genital organs from infections

Tea tree oil in the composition of the product has an antibacterial and antiviral effect

Reduces itching and irritation 9000 3

Where to buy Zalagel ^® Intim

or

Find the nearest pharmacy

Instruction

Answers to questions

How to understand that thrush has become chronic?

Answer: Four or more episodes of thrush per year are in favor of chronic recurrent urogenital candidiasis.

How long does the treatment for versicolor take?

Answer: Treatment of tinea versicolor, as a rule, consists in prescribing external antifungal therapy. The duration of treatment is selected individually and usually lasts at least 2 weeks.

Is it possible to wet the skin with candidiasis of the folds?

Answer: In the acute period of the disease, until the skin process stabilizes, it is necessary to limit contact with water.

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Sources

1. Russian clinical guidelines.
2. Textbook “Skin and venereal diseases” edited by O.L. Ivanov., 2010.
3. National Guide to Dermatovenereology edited by prof. Yu.S. Butova, acad. RAMS Yu. K. Skripkina, prof. O.L. Ivanov.
4. Clinical guidelines of the Russian Federation, Urogenital candidiasis 2019.
5. Efficacy and safety study of Zalain® 2% cream in the treatment of skin mycoses. IG Sergeeva, Yu. M. Krinitsyna Novosibirsk State University.
6. Register of Medicines of Russia, official instructions for the active substance Sertaconazole.
7. Register of Medicines of Russia, official instructions for Zalain® 2% cream.
8. Register of Medicines of Russia, official instructions Zalain 300 mg, vaginal suppositories.
9. RMJ No. 9, 2015. “Vulvovaginal candidiasis. The use of Zalain in clinical practice. E. S. Vanke, N. S. Vanke.
10. Mondello F, De Bernardis F, Girolamo A, Cassone A, Salvatore G. In vivo activity of terpinen-4-ol, the main bioactive component of Melaleuca alternifolia Cheel (tea tree) oil against azole-susceptible and -resistant human pathogenic Candida species. BMC Infect Dis. 2006;6:158.
11. Hammer KA, Carson CF, Riley TV. In vitro susceptibilities of lactobacilli and organisms associated with bacterial vaginosis to Melaleuca alternifolia (tea tree) oil. Antimicrob Agents Chemother 1999;43:196.
12. Pena EF. Melaleuca alternifolia oil. Its use for trichomonal vaginitis and other vaginal infections. Obstet Gynecol 1962;19:793-5.
13. Astani A, Reichling J, Schnitzler P. Comparative study on the antiviral activity of selected monoterpenes derived from essential oils. Python Res 2009; 24(5):673-9.
14. Bassett, I. B., D. L. Pannowitz, and R. S. Barnetson. 1990. A comparative study of tea-tree oil versus benzoylperoxide in the treatment of acne. Med. J. Aust.