Terconazole Vaginal (Terazol 7) – Side Effects, Interactions, Uses, Dosage, Warnings

Reviewed: June 23, 2020

Terconazole is an antifungal medication that fights infections caused by fungus.

Terconazole vaginal (for use in the vagina) is used to treat vaginal Candida (yeast) infections.

Terconazole vaginal may also be used for purposes not listed in this medication guide.

uses

What is Terconazole Vaginal (Terazol 7) used for?

• Vaginal Candidiasis

warnings

What is the most important information I should know about Terconazole Vaginal (Terazol 7)?

You should not use terconazole vaginal if you are allergic to it.

Do not use this medicine if you have never had a vaginal yeast infection that has been confirmed by a doctor.

To make sure terconazole vaginal is safe for you, tell your doctor if you have:

• fever, chills, vomiting;
• pelvic pain, vaginal discharge with a bad odor;
• if you are having vaginal itching or discomfort for the first time; or
• if you think you may have been exposed to HIV (human immunodeficiency virus).

It is not known whether terconazole vaginal will harm an unborn baby. Tell your doctor if you are pregnant.

It is not known whether terconazole vaginal passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

Do not give this medication to anyone under 18 years old without medical advice.

Side Effects

What are the side effects of Terconazole Vaginal (Terazol 7)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

• new or worsening symptoms;
• fever, chills, flu symptoms;
• severe vaginal irritation; or
• severe skin reaction–fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common side effects may include:

• headache;
• body pain;
• vaginal pain, burning, or itching;
• stomach pain; or
• increased menstrual cramps.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Pregnancy & Breastfeeding

Can I take Terconazole Vaginal (Terazol 7) if I’m pregnant or breastfeeding?

C

Risk cannot be ruled out

Based on FDA pregnancy categories

It is not known whether terconazole vaginal will harm an unborn baby. Tell your doctor if you are pregnant.

It is not known whether terconazole vaginal passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

Interactions

What drugs and food should I avoid while taking Terconazole Vaginal (Terazol 7)?

Avoid having sexual intercourse during treatment, unless your doctor says that you may.

Do not use a tampon, vaginal douche, or other vaginal products while you are using terconazole vaginal.

Avoid wearing tight-fitting, synthetic clothing such as nylon underwear or panty hose that does not allow air circulation. Wear loose-fitting clothing made of cotton and other natural fibers until your infection is healed.

Dosage Guidelines & Tips

How to take Terconazole Vaginal (Terazol 7)?

Use Terconazole Vaginal (Terazol 7) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

What should I do if I missed a dose of Terconazole Vaginal (Terazol 7)?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

Overdose Signs

What happens if I overdose on Terconazole Vaginal (Terazol 7)?

An overdose of terconazole vaginal is unlikely to occur.

If you think you or someone else may have overdosed on: Terconazole Vaginal (Terazol 7),  call your doctor or the Poison Control center

(800) 222-1222

If someone collapses or isn’t breathing after taking Terconazole Vaginal (Terazol 7), call 911

911

Find Another Drug

Search prescription drugs, over-the counter medications, and supplements

Medical Disclaimer

Drugs A-Z provides drug information from Everyday Health and our partners, as well as ratings from our members, all in one place. Cerner Multum™ provides the data within some of the Overview, Uses, Warnings, Side Effects, Pregnancy, Interactions, Dosage, Overdose, and Images sections. The information within all other sections is proprietary to Everyday Health. 

Terconazole Vaginal Cream, Vaginal Suppositories: MedlinePlus Drug Information

pronounced as (ter kon’ a zole)

To use the sharing features on this page, please enable JavaScript.

Terconazole is used to treat fungal and yeast infections of the vagina.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Terconazole comes as a cream and suppository to insert into the vagina. It is usually used daily at bedtime for either 3 or 7 days. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use terconazole exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.

To use the vaginal cream or vaginal suppositories, read the instructions provided with the medication and follow these steps:

1. To use the cream, fill the special applicator that comes with the cream to the level indicated. To use the suppository, unwrap it, wet it with lukewarm water, and place it on the applicator as shown in the accompanying instructions.
2. Lie on your back with your knees drawn upward and spread apart.
3. Insert the applicator high into your vagina (unless you are pregnant), and then push the plunger to release the medication. If you are pregnant, insert the applicator gently. If you feel resistance (hard to insert), do not try to insert it further; call your doctor.
4. Withdraw the applicator.
5. Pull the applicator apart and clean it with soap and warm water after each use.
6. Wash your hands promptly to avoid spreading the infection.

The dose should be applied when you lie down to go to bed. The drug works best if you do not get up again after applying it except to wash your hands. You may wish to wear a sanitary napkin to protect your clothing against stains. Do not use a tampon because it will absorb the drug. Do not douche unless your doctor tells you to do so.

Continue to use terconazole even if you feel well. Do not stop using terconazole without talking to your doctor. Continue using this medication during your menstrual period.

Before using terconazole,

• tell your doctor and pharmacist if you are allergic to terconazole or any other drugs.
• tell your doctor and pharmacist what prescription and nonprescription drugs you are taking, especially antibiotic medications and vitamins.
• tell your doctor if you have or have ever had problems with your immune system, human immunodeficiency virus infection (HIV), acquired immunodeficiency syndrome (AIDS), or diabetes.
• tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using terconazole, call your doctor immediately. Terconazole may harm the fetus.

Insert the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not insert a double dose to make up for a missed one.

Terconazole may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• headache
• missed menstrual periods

If you experience any of the following symptoms, call your doctor immediately:

• burning in vagina when cream or suppository is inserted
• irritation in vagina when cream or suppository is inserted
• stomach pain
• fever
• foul-smelling vaginal discharge

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online (http://www. fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication tightly closed, in the container it came in, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA’s Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

• Terazol^® 3
• Terazol^® 7

Last Revised – 02/15/2018

Browse Drugs and Medicines

Pimafucin instructions for use, price: Composition, analogues, active substance

THERE ARE CONTRAINDICATIONS. POSSIBLE SIDE EFFECTS. A SPECIALIST’S CONSULTATION IS REQUIRED

WHO data show that every fifth person on the planet has had a fungal infection at least once in their life. Candida (fungi) affects a weakened organism, which is affected by poor ecology, medication, the use of chemicals in everyday life and agriculture. Candidiasis can affect any human organ.

Many fungal infections worldwide are treated with Pimafucin. We asked the pharmacist Anna Sumenkova to tell about its composition and active ingredient, how to take the drug in tablets correctly and introduce it to its analogues.

All products Pimafucin

20 reviews

Pimafucin: active ingredient

The active ingredient in Pimafucin preparations is natamycin. It is an antibiotic of the macrolide group with an antifungal effect. It binds to the fungal cell membrane substance ergosterol and causes cell death. Most molds and yeasts are susceptible to natamycin. Clinical practice has not registered cases of resistance to this antibiotic.

Pimafucin: Composition

All dosage forms of the drug contain one active ingredient – natamycin. In pharmacies you can buy:

• Pimafucin enteric-coated tablets, 100 mg each. Tablets are used for intestinal candidiasis and for sanitation of the intestines from fungi Candida in case of damage to the skin and mucous membranes.
• Pimafucin vaginal suppositories 100 mg, pack of 3 and 6. They are used for “thrush”: lesions of the fungus Candida genital organs of women – vaginitis, vulvovaginitis, vulvitis. The suppositories contain cetyl alcohol, which can cause a burning sensation. Pimafucin suppositories are approved for use during pregnancy and lactation.
• Pimafucin cream for external use 2%. In pharmacies, Pimafucin ointment is often asked: in this form, the remedy is not available, perhaps patients confuse it with a cream. Pimafucin for external and local use is not absorbed through the skin and mucous membranes. It is prescribed for candidiasis of the skin and nails, “thrush” and ringworm. With external otitis – in the case when it is caused or complicated by candidiasis. Pimafucin cream is used to treat men with balanoposthitis and in the presence of “thrush” in a partner.

You may be interested in: How to quickly and effectively cure thrush in women and men

Pimafucin tablets: how to take

Pimafucin tablets act only in the intestinal lumen. Eating does not affect the effect of the medicine.

• Adult dosage: 1 tablet 4 times a day.
• For children: 1 tablet 2 times a day.

Intestinal candidiasis is treated for up to 7 days.

For the treatment of persistent vaginitis, tablets are taken in combination with Pimafucin suppositories for 10-20 days.

The duration of treatment is determined by the doctor individually. When the symptoms of candidiasis disappear, therapy should be continued for a few more days.

Pimafucin tablets may cause side effects in the first days of use. This is manifested by nausea or vomiting, which pass on their own, without interrupting treatment.

Pimafucin analogues

Pimafucin analogues with the active substance natamycin are represented by the following preparations:

• Primafungin vaginal suppositories
• Natamycin vaginal suppositories
• Primacin vaginal suppositories, topical cream, tablets
• Ecofucin vaginal suppositories

Indications and contraindications are identical to Pimafucin.

Similar indications for use with Pimafucin have:

• Clotrimazole – has a wide range of indications for genital infections
• Livarol, Ginofort, Zalain – are prescribed for vaginal candidiasis
• Amintax vaginal suppositories and Polygynax vaginal capsules are combined preparations with bactericidal and antifungal effects. They include nystatin, polymyxin B, neomycin. They are used for the treatment of mixed infections, for prophylaxis before diagnostic procedures, operations and childbirth.

All products Ecofucin

5 reviews

All products Natamycin

5 reviews

Nystatin or Pimafucin: which is better

The active ingredient of Nystatin is an antibiotic of the same name, active against Candida fungi. The mechanism of action is associated with the destruction of the cell membrane, as in Pimafucin. Indications for use and dosage forms (cream, suppositories, tablets) are similar to Pimafucin preparations. Nystatin has more side effects (chills, fever, allergic reactions, nausea, vomiting, diarrhea).

A comparison of these two antimycotics shows the advantage of Pimafucin. Its safety profile is higher: it is allowed for pregnant and lactating women and children. Nystatin is prohibited during pregnancy and lactation, children are prescribed only from the age of 13.

Summary

• The antibiotic natamycin is the active ingredient in all dosage forms of Pimafucin.
• Pimafucin is available in three formulations with one active ingredient: tablets, topical cream and vaginal suppositories.
• Pimafucin tablets are taken orally with or without food. The duration of the course of treatment is set individually.
• Pimafucin has direct analogues with natamycin and group analogues with other active ingredients.
• Unlike Nystatin, Pimafucin can be prescribed to children, pregnant women, and lactating women.

Ask an expert about the topic of the article

Still have questions? Ask them in the comments below and our experts will answer you. There you can also share your experience with other readers of Megasovets.

Share the mega tip

Like this article? Tell mom, dad, grandma and aunt Galya from the third entrance

Copy link

What is candidiasis? Treatment of candidiasis in women. Treatment of candidiasis quickly

Candidiasis is often referred to as thrush. With this pathology, yeast-like fungi from the genus Candida affect the mucous membranes and skin of the genital organs and mouth. This is a conditionally pathogenic agent, that is, in a small amount, the fungus exists in the composition of the microflora of the skin of any person, but due to immune protection, it does not actively reproduce. When immunity decreases for some reason, microorganisms begin to increase in number, and thrush occurs.

Since there are a lot of fungi of the genus Candida – more than 80 species – it is important to choose the right medicine for the treatment of candidiasis. Otherwise, you can get a strain that will endure the action of the drug and hinder the positive outcome of treatment.

The most common oral (in infants and infants) and vaginal candidiasis (both sexes suffer from it). This article describes the latest variety of thrush.

What are the causes of the disease?

3 groups of factors can provoke thrush:

1. Exogenous;
2. Endogenous;
3. Direct exposure to pathogens.

Exogenous, that is, external, factors occur when pathogenic fungi increase their chances of infection due to environmental conditions conducive to this. This happens if:

• at work, the fungus is found in the air in an increased amount;
• people sweat a lot and often because of the high temperature of the environment;
• hygiene is not observed or observed incorrectly.

Endogenous, that is, internal, factors originate in the body itself. It may be less resistant to fungal growth if the person is suffering:

• avitaminosis, because they do not consume enough vitamins with food;
• obesity, diabetes mellitus, ulcerative colitis and other diseases in which metabolism is disturbed;
• Itsenko-Cushing’s syndrome, in which the adrenal glands produce an excessive amount of cortisol;
• chronic infections;
• VVD, in which sweating is increased;
• neoplasms;
• thyrotoxicosis, in which the thyroid gland produces a lot of hormones;
• diseases of the hematopoietic system, etc.

Subject to the presence of these provoking factors, the pathogenic properties of the pathogen are actively manifested.

What are the symptoms of candidiasis?

Thrush often affects adult women, but can also occur in female children and men. In children, candidiasis affects the external and internal genital organs, and in the stronger sex, the glans penis and foreskin.

Women of childbearing age may notice thrush by the following symptoms:

• there is discomfort during intercourse;
• mucous membrane became swollen and red;
• discharge became cheesy and smells sour;
• urination accompanied by pain and burning;
• before or after critical days the genitals itch;
• itching occurs if hygienic procedures are not performed in time or if you get too cold.

Men can understand the presence of the disease by the following manifestations:

• pain during intercourse and urination;
• a white coating of curdled consistency forms on the head of the penis;
• the head of the penis itches, hurts, is red.

If you find such signs, you should definitely seek medical help. It is provided to women by a gynecologist, and to men by a urologist.

How to diagnose a disease?

To make a correct diagnosis, resort to the following procedures:

1. Analysis of a smear for candidiasis with a study under a microscope. To do this, the doctor takes a special swab and makes a scraping of the vagina to obtain a smear. Then do a microscopic examination of the scraping. If there is an infectious disease, Candida fungi will be found in the smear.

2. Sowing. After obtaining a smear, a culture of the fungus is grown. If the colony size exceeds 10,000 cfu/ml, the diagnosis is candidiasis. If this value is less, this may indicate a normal amount of the microorganism in the vagina.

3. Determining the variety of the pathogen and its sensitivity to the drug.

How is candidiasis treated?

If the thrush in a woman is easy, you can use local therapy – vaginal suppositories, ointments or creams for fungi in the form of clotrimazole, miconazole, etc.

The use of suppositories and creams will allow you to forget about the problem in 7 days, and modern medicines – in 1-2 days. To ensure that the disease does not return, the course can be repeated 2 times. Sometimes you can get by with a single dose of drugs based on fluconazole at a dose of 150 mg.

If the infection recurs, it is important not only to remove the symptoms, but also to prevent relapse. Local treatment in this case is supplemented with oral medications, which must be chosen based on the type of pathogen. It is important to undergo regular examinations during the treatment period.

To support immunity, you need to supplement the diet with bifidobacteria and exclude irritating foods. Sexual contacts during therapy also stop.

For the vast majority of cases of thrush in the stronger and weaker sex, local external agents with antifungal properties are sufficient. You can use a cream or ointment that contains clotrimazole. You will have to smear the affected area twice a day. The full course does not exceed 7 days. As an additional treatment, if the results of local therapy are mild, medications may be prescribed.

Candidiasis, the treatment of which was started on time, is not harmful to health. But with a long-term, chronically current disease, the kidneys and other parts of the urinary system can be affected. Untreated patients can become infertile (this also applies to men, whose reproductive organs can be severely affected in serious cases).

How to prevent the development of pathology?

Preventing thrush is much better than treating it. Disease can be avoided:

• limiting close contact with infected patients;
• carefully and timely observing hygiene;
• taking probiotics while being treated with antibiotics;
• preferring cotton underwear;
• limiting casual sex;
• timely treating diseases of the genitourinary profile.

Compliance with these simple preventive measures will help maintain health for many years.