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Yeast infection on skin cream: First Aid Information for Yeast Infection Skin Rash


First Aid Information for Yeast Infection Skin Rash

Self-Care at Home


Most candidal (yeast) infections can be treated at home with over-the-counter or prescription medication and will clear up within a week. If some other disease has weakened a person’s immune system, the person should consult a doctor about any new symptoms before attempting self-treatment because of the risk of infection.

  • Thrush
    • For thrush, swish the antifungal agent nystatin around in your mouth then swallow the liquid. Take care to maintain excellent oral hygiene.
    • All objects put into a child’s mouth should be washed or sterilized after each use.
    • Breastfeeding mothers should be evaluated for Candida infection of the breast.
    • If you wear dentures, clean them thoroughly after each use and practice good oral hygiene.
    • Adults and older children have several treatment options not available to babies, such as troches (antifungal lozenges) or pills such as fluconazole (Diflucan) to help clear the infection in addition to nystatin.
  • Skin and diaper rash
    • Clotrimazole (Lotrimin) creams and lotions can be applied to superficial skin infections. Other medications require a prescription and a visit to your doctor.
    • Other antifungal creams, such as ketoconazole (Nizoral), which is available by prescription, is helpful as well.
    • For paronychia, a skin rash around the nails, avoiding moisture can be helpful. Oral itraconazole (Sporanox) or fluconazole (Diflucan) can also be helpful and can be prescribed by a doctor. Topical antifungal and topical corticosteroids are also used.
    • Perlèche is treated with topical antiyeast or antifungal agents, and often with a mild corticosteroid cream. Limit lip licking of the corners of the mouth. Placing a bit of petroleum jelly on top of the antiyeast agents can be helpful as well.
    • The affected area should be kept clean and dry.
    • For diaper rashes, frequent diaper changes and the use of barrier creams speed recovery .
    • Intertrigo can benefit from the use of nystatin powder, which decreases the amount of moisture and also acts as an antiyeast agent.

Medical Treatment


A wide array of treatment options is available to treat candidiasis. Options include creams, lotions, tablets or capsules, troches (lozenges), and vaginal suppositories or creams. Talk to your doctor to find the option that is right for you.

  • Azole medications are a family of antifungal drugs that end in the suffix “-azole.” They block the manufacture of ergosterol, a crucial material of the yeast cell wall. Without ergosterol, the yeast cell wall becomes leaky and the yeast die. Fortunately, ergosterol is not a component of human membranes, and azoles do not harm human cells.
  • Polyene antifungal medications include nystatin and amphotericin B. Nystatin is used for thrush and superficial candidal infections. Doctors reserve amphotericin B for more serious systemic fungal infections. The antifungals work by attaching to the yeast cell wall building material, ergosterol. These medications then form artificial holes in the yeast wall that cause the yeast to leak and die.

Nystatin skin cream or ointment

What is this medicine?

NYSTATIN (nye STAT in) is an antifungal medicine. It is used to treat certain kinds of fungal or yeast infections of the skin.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Mycostatin, Nystex, Pediaderm AF

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • an unusual or allergic reaction to nystatin, other foods, dyes or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

This medicine is for external use on the skin only. Follow the directions on the prescription label. Wash hands before and after use. If treating a hand or nail infection, wash hands before use only. Apply a thin layer of this medicine to cover the affected skin and surrounding area. You can cover the area with a sterile gauze dressing (bandage). Do not use an airtight bandage (such as a plastic-covered bandage). Do not get the medicine in your eyes. If you do, rinse out with plenty of cool tap water. Use the full course of treatment prescribed, even if you think the infection is getting better. Use at regular intervals. Do not use your medicine more often than directed. Do not use this medicine for any condition other than the one for which it was prescribed.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.

What may interact with this medicine?

Interactions are not expected. Do not use any other skin products on the affected area without telling your doctor or health care professional.

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Tell your doctor or health care professional if your symptoms do not improve after 3 days.

After bathing make sure that your skin is very dry. Fungal infections like moist conditions. Do not walk around barefoot.

To help prevent reinfection, wear freshly washed cotton, not synthetic, clothing.

What side effects may I notice from receiving this medicine?

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature 15 to 30 degrees C (59 to 86 degrees F). Throw away any unused medicine after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Tinea versicolor – Diagnosis and treatment


Your doctor can diagnose tinea versicolor by looking at it. If there’s any doubt, he or she may take skin scrapings from the infected area and view them under a microscope.


If tinea versicolor is severe or doesn’t respond to over-the-counter antifungal medicine, you may need a prescription-strength medication. Some of these medications are topical preparations that you rub on your skin. Others are drugs that you swallow. Examples include:

  • Ketoconazole (Ketoconazole, Nizoral, others) cream, gel or shampoo
  • Ciclopirox (Loprox, Penlac) cream, gel or shampoo
  • Fluconazole (Diflucan) tablets or oral solution
  • Itraconazole (Onmel, Sporanox) tablets, capsules or oral solution
  • Selenium sulfide (Selsun) 2.5 percent lotion or shampoo

Even after successful treatment, your skin color may remain uneven for several weeks, or even months. Also, the infection may return in hot, humid weather. In persistent cases, you may need to take a medication once or twice a month to prevent the infection from recurring.

Lifestyle and home remedies

For a mild case of tinea versicolor, you can apply an over-the-counter antifungal lotion, cream, ointment or shampoo. Most fungal infections respond well to these topical agents, which include:

  • Clotrimazole (Lotrimin AF) cream or lotion
  • Miconazole (Micaderm) cream
  • Selenium sulfide (Selsun Blue) 1 percent lotion
  • Terbinafine (Lamisil AT) cream or gel
  • Zinc pyrithione soap

When using creams, ointments or lotions, wash and dry the affected area. Then apply a thin layer of the product once or twice a day for at least two weeks. If you’re using shampoo, rinse it off after waiting five to 10 minutes. If you don’t see an improvement after four weeks, see your doctor. You may need a stronger medication.

It also helps to protect your skin from the sun and artificial sources of UV light. Usually, the skin tone evens out eventually.

Preparing for your appointment

You’re likely to start by first seeing your family doctor or a general practitioner. He or she may treat you or refer you to a specialist in skin disorders (dermatologist).

What you can do

Preparing a list of questions beforehand can help you make the most of your time with your doctor. For tinea versicolor, some basic questions to ask your doctor include:

  • How did I get tinea versicolor?
  • What are other possible causes?
  • Do I need any tests?
  • Is tinea versicolor temporary or long lasting?
  • What treatments are available, and which do you recommend?
  • What side effects can I expect from treatment?
  • How long will it take for my skin to return to normal?
  • Can I do anything to help, such as avoid the sun at certain times or wear a specific sunscreen?
  • I have other health conditions. How can I best manage them together?
  • Is there a generic alternative to the medicine you’re prescribing me?
  • Do you have brochures or other printed material I can take home? What websites do you recommend?

What to expect from your doctor

Your doctor is likely to ask you a number of questions, such as:

  • How long have you had these discolored areas on your skin?
  • Have your symptoms been continuous or occasional?
  • Have you had this or a similar condition in the past?
  • Do the affected areas itch?
  • Does anything seem to improve your symptoms?
  • What, if anything, appears to worsen your symptoms?

Vaginal yeast infections (thrush): What helps? – InformedHealth.


Vaginal infections are often caused by an overgrowth of yeast (a type of fungus). Yeast infections in the vagina usually go away after a short course of treatment with antifungal medication. It’s not clear whether home remedies help.

Many women are familiar with the symptoms of vaginal yeast infections: unpleasant itching and burning, as well as whitish cottage-cheese-like vaginal discharge. Vaginal yeast infections are treated with antifungal drugs (antimycotics). The symptoms usually go away after a short course of treatment with these medications when used locally in the vagina.

It is sometimes a good idea to take oral medication (swallowed in the form of tablets) or to use a longer-term treatment.

How are antifungal drugs normally used?

Antifungal drugs kill or reduce the growth of fungi (including yeast). The following medications are often used to treat vaginal yeast infections:

  • Clotrimazole

  • Nystatin

  • Ciclopirox

  • Fluconazole

Fluconazole is only available as a tablet, and you need a prescription to get it. Most of the creams and vaginal suppositories are available from pharmacies without a prescription. In Germany and other countries you have to pay for them yourself, though.

Simple infections clear up after a few days of locally applied treatment (vaginal suppositories or creams). Depending on the drug used, the treatment takes one, three or six days. It’s best to insert suppositories deep into the vagina before going to sleep. Most packages have an applicator in them, as well instructions, to help you insert the suppository. Creams also often come with an applicator to help you apply them inside the vagina. Vaginal suppositories sometimes come with a small tube of antifungal cream that you can apply to inflamed areas of the external (outer) genitals.

There is also a different treatment where you take (swallow) just one tablet. Doctors may recommend using that if you have your period, for instance.

If you keep getting vaginal yeast infections, your sex partner may have one in their genital area too – with similar symptoms, such as redness and itching at the tip of their penis or in their vagina. Then you might keep infecting each other. To prevent this kind of “ping pong effect,” it can be a good idea for your partner to see a doctor and use antifungal medication if necessary.

What are the risks associated with antifungal drugs?

Antifungal drugs that are applied to the skin or mucous membranes are generally well tolerated. The possible side effects include further irritation of the inflamed areas, burning and itching.

When using mechanical contraceptive devices, it’s important to read the package insert carefully. Some antifungal drugs are oily. This can make contraceptives like condoms more porous, allowing sperm to pass through them.

If antifungal drugs are taken in the form of tablets that you swallow, they can lead to other side effects such as headaches, dizziness, nausea and diarrhea. There are also a lot of medications that shouldn’t be used together with antifungal drugs because they may influence each other’s effect. These include certain allergy medicines, blood-pressure-lowering drugs and medications for psychological problems. You can find out about these “drug-drug interactions” in the package insert that comes with the antifungal drug.

Antifungal drugs that you swallow (oral antifungals) haven’t been approved for use in women who are pregnant or breastfeeding. But those that are used locally in the vagina (creams and suppositories) can be used by this group of women.

When is a longer-term treatment considered?

If you have a complicated vaginal yeast infection, it’s a good idea to talk to your doctor. He or she may recommend using a treatment over a longer period of time. A vaginal yeast infection is considered to be “complicated” if it causes more severe symptoms such as widespread, painful swelling in the vagina and on the outer genitals – or if the infection recurs more than four times per year. Yeast infections are also considered to be complicated if they’re caused by a weakened immune system, for instance due to an HIV infection.

When treating complicated vaginal yeast infections, an initial treatment is typically followed by maintenance treatment. In the initial phase of treatment,

  • creams or suppositories are used for 1 to 2 weeks, or

  • instead, one oral tablet is taken every three days for about a week.

This is usually followed by maintenance treatment, where you take one antifungal tablet per week over a period of six months. If you can’t take tablets – for instance, due to a pregnancy or interactions with other drugs – you can use only creams or suppositories for the whole treatment period.

Are there effective alternatives to antifungals?

The membranes lining a healthy vagina contain a lot of lactic acid bacteria. These bacteria are a normal part of the vaginal flora – the natural balance of microorganisms (germs) there. Small amounts of yeast are also normal. If this natural balance is upset, harmful bacteria or yeast can thrive and lead to an inflammation.

There are vaginal suppositories or capsules that contain live lactic acid bacteria (probiotics). These products are designed to protect and restore the natural balance in the vagina. They may help to fight a yeast infection when used in addition to antifungal drugs. But it’s not clear whether they can effectively fight a yeast infection when used on their own.

Some women use home remedies to treat vaginal yeast infections. For instance, they may eat garlic or natural yogurt. Others insert garlic cloves into their vagina, or use tampons soaked in things like tea tree oil or natural yogurt. But there’s hardly any research on whether these kinds of home remedies can help to get rid of vaginal yeast infections or prevent them. They are, however, associated with risks such as allergic reactions or irritated mucous membranes. Vaginal douches or female intimate hygiene products may irritate the skin, making the inflammation worse.

Can Face Masks Cause Yeast Infections?

Face masks have become a mainstay this year, thanks to COVID-19. You can find masks in an assortment of styles and colors as they have become a necessary fashion accessory to add to your wardrobe. But when the mask comes off, what is waiting underneath?  Some mask wearers are finding that the regular use of facial coverings are beginning to exacerbate skin conditions like acne and rosacea. Others are finding rashes on their faces they have never seen before. It turns out the warm, moist environment under the mask can be the ideal place for a yeast infection to develop.

Yeast Infections? On the Face?

Many women are all too familiar with yeast infections as they can be a common vaginal issue. However, most of us have never heard of a yeast infection affecting visible areas like the face. It is the introduction of regular mask wearing that has brought this issue to light.  Dr. Sapna Palep, founder of Spring Street Dermatology in New York City, recently broached the issue of yeast infections from mask wear. She has some basic facts about why they occur and what you can do to lower your risk.

Q: Is it possible to get a yeast infection on your face from wearing a mask?

Yes, absolutely! Dr. Palep warns that a yeast infection can occur anywhere there is warm, moist, creased skin. Candida albicans is the most common culprit that takes advantage of this environment, which can be created by masks to create a superficial fungal infection. Yeast is present on the skin and usually causes no ill effects. However, the right combination of factors can allow it to develop into an infection. It’s not the mask itself that causes the problem. But wearing a mask for extended periods of time, particularly in these hot, sticky days of summer, can encourage the factors that lead to infection. 

Q: Does the summer heat play a role here in determining if a yeast infection will develop?

Dr. Palep explains that the area under the mask can generate heat and moisture, which creates an environment that is hospitable to a yeast infection. Hot weather and humidity make it even easier for yeast to grow as these factors up the heat and moisture that builds underneath the mask. Pay special attention to those skin creases around the nose and mouth that are hidden under your mask. While you may appreciate the ability to cover up those aging symptoms, they are also the places where yeast infections will thrive. If you notice any changes to the skin within those creases, contact your dermatologist. 

Q: Are there certain skin types who are more predisposed to developing an infection like this?

Dr. Palep says that oilier skin types, acne and rosacea-prone skin are more predisposed to a potential infection. On the flip side, drier skin types can also be susceptible to yeast infections. In addition, people that suffer from other types of skin conditions are likely to see flare-ups with mask wearing that could raise their risk for infection. Conditions like eczema, in addition to rosacea and acne that Dr. Palep mentioned, can all become more problematic when under a mask for prolonged periods. 

Q: Are there certain mask materials that are more predisposed to spreading this kind of infection?

Dr. Palep said the best thing you can do is look for a mask that uses a breathable fabric, like cotton.   A lot of people can’t tolerate certain synthetic fabrics on their face.  Cotton is the best fabric for masks, as it’s the most comfortable and breathable on skin so you can wear it all day long. The worst materials to use are merino wool, cashmere, and lightweight ramie (like linen). It is essential to wash your masks regularly, in a gentle detergent that is less likely to irritate the skin. Avoid soaps that have harsh chemicals or strong fragrances, as these are likely to set off a reaction that could make you more prone to bigger issues. 

Q: Does the length of time in the mask make a difference in how likely you are to experience a reaction?

Most definitely. Dr. Palep explains that the longer you wear your mask, the more humidity, moisture, and sweat builds up, creating the perfect environment for yeast. In addition, the constant pressure of a mask causes cracks and fissures in the skin, which also produce an ideal environment for yeast.

Q: How do I know if I have a yeast infection?

Dr. Palep lists some of the warning signs as small raised blisters, pustules, rash, soreness, and chaffing. It’s important to see a board certified dermatologist immediately when you start to see the signs of it as it can worsen very quickly. 

Q: How do I treat a yeast infection if I get one?

The good news is you can usually treat a yeast infection at home, using topical products. Dr. Palep recommends over-the-counter antifungal medications like miconazole, clotrimazole, or lotrimin. She warns that you should never use serums and oils on a yeast infection as they could worsen the condition. 

Contact Spring Street Dermatology in Manhattan, New York Today

A yeast infection could be an unwanted byproduct of mask-wearing, but the good news is that if you catch it early, it can be treated easily with simple over-the-counter topical medications. If you are concerned about any changes to your skin as a result of your mask, contact our office today to schedule an appointment.

The 3 Best Yeast Infection Creams

While the excessive fungal growth that causes a yeast infection can happen just about anywhere on the body, including in nail beds, the belly button, and under the breasts, the most talked-about kind is probably vaginal. Symptoms like itching, burning, and redness are annoying anywhere, but are made even worse when they hit sensitive regions. That’s why it’s so important to find the best yeast infection cream for your needs to solve the problem quickly but effectively.

Choosing an over-the-counter cream with “actual antifungal medication” is essential, says Margaret Sullivan, MD, obstetrician and gynecologist at Tufts Medical Center. Some products like Vagisil only “numb the area but don’t treat the yeast,” she warns.

“There are three effective over-the-counter treatments available in the U.S.,” Daniel Breitkopf, MD, obstetrician and gynecologist at the Mayo Clinic explains. “These include creams that contain miconazole, clotrimazole, and tioconazole. There are not significant differences in effectiveness between these medications.” Those who are pregnant, have diabetes, or suffer especially severe symptoms should consult a doctor before using one of these treatments.

If your symptoms don’t improve after a few days of OTC treatment, or you’re getting recurring infections, it’s a good idea to call a doctor, too, Dr. Sullivan says. In her practice, she commonly prescribes oral Diflucan because it’s “easy to use, no messy creams.”

When a yeast infection strikes, don’t fear and definitely don’t feel ashamed. Yeast infections are not a matter of cleanliness, and douching will only irritate the area.

You don’t need to turn your lifestyle upside down, either. “There is not good scientific evidence that changes in diet, sexual behavior, or probiotics are effective in reducing the chance of getting a yeast infection,” Dr. Breitkopf says, though he notes that switching birth control with your doctor can sometimes help.

When life (and yeast infections) happen, tackle them by arming yourself with these picks for the best creams to treat vaginas and beyond.


The Best Overall Pick For Vaginal Yeast Infections

When deciding between a one-, three-, or seven-day product, Dr. Sullivan says that “the length … is the patient’s preference” since “each course has the same total biologic dose.” Other ob-gyns have mentioned that a one-day treatment is not always the most effective but consider if you want to apply treatments for an entire week. It’s also worth noting that one-day treatments still usually take more than a single day to clear up a yeast infection.

This middle ground three-day Monistat regimen contains vaginal ovules (with a disposable applicator for each) to deliver the actives as easily as you’d use a tampon, a medicated cream for external use, and even soothing wipes to help clean up.

Miconazole, the active ingredient, is one the most commonly used antifungals for vaginal yeast infections. And while having effective actives is an important start, this treatment sets itself apart by the ease of use — which is why it’s the top pick.

The cons are that it’s the priciest on the list, and a few reviewers report experiencing irritation. So if you have a sensitive vagina, it might be best to ask a doctor first.


The Best Budget Pick For Vaginal Yeast Infections

This pack of two regimens is less than a single box of Monistat’s ovules product, making it an excellent budget alternative.

Most customers found the active ingredient clotrimazole to work well, with some even noting that it worked when other antifungals weren’t effective or caused sensitivity for them. “This 3-day clotrimazole was great even on my sensitive body … I had zero side effects, only relief,” one review says. “I like that the cream is thick enough that it stays in place so it can absorb properly.”

While you have to pack the applicators with the medicated cream yourself with this one, a reviewer noted that it was “not that difficult.” However, a few found that the applicators were difficult and uncomfortable to use.


A Multipurpose Choice For Non-Vaginal Yeast Infections

Customers rave about this tiny tube’s ability to tackle yeast infections on skin. “As a diabetic, I can have problems with skin yeast infections. This cream works quite well to clear them up and keep them from recurring,” says a reviewer. Some even used it for vaginal yeast infections and said it worked.

It shares the same doctor-recommended active ingredient as Monistat, and at less than $10 per tube — and with big discounts if you buy it in a pack of three or six — it’s also a great deal. Customers found it effective against other fungal skin infections like athlete’s foot, jock itch, and ringworm, making it an inexpensive multitasker to consider keeping in the first aid kit.


A Non-Prescription Alternative To Antifungal Creams

If your yeast infection is resistant to traditional antifungal creams or seriously recurring, boric acid suppositories are something to consider. Boric acid has antifungal properties, and this popular bottle has more than 2,700 reviews with a 4.5 overall rating.

However, Dr. Sullivan notes, “Boric acid and gentian violet are older regimens that are rarely used.” Other things to consider: Don’t take boric acid orally, apply it to open wounds, or leave it out where pets or children can reach it because it can potentially be toxic. Pregnant women should not use it, either. And though rare, the possible side effects of boric acid suppositories include “vaginal burning and itching,” according to Our Bodies Ourselves. In other words, it’s a good idea to ask a doctor first before trying these.

Bustle may receive a portion of sales from products purchased from this article, which was created independently from Bustle’s editorial and sales departments.

Miconazole | Clotrimazole – MotherToBaby

This sheet talks about exposure to miconazole or clotrimazole in pregnancy and while breastfeeding. This information should not take the place of medical care and advice from your healthcare providers.

What is miconazole?

Miconazole is a medication used to treat fungal infections. Miconazole is most often used as a cream on the skin to treat skin infections, or as a vaginal cream that is placed in the vagina to treat vaginal yeast infections. Vaginal creams (such as the brand name Monistat®) are used for 1 day, 3 days, or 7 days. Your healthcare provider can help you decide which length of treatment is right for you.

What is clotrimazole?

Clotrimazole is also a medication used to treat fungal infections. Like miconazole, clotrimazole is available as a topical cream used on the skin or as a vaginal cream used in the vagina. Clotrimazole is sold under brand names including Femcare®, Lotrimin®, and Mycelex®.

What should I do if I think I have a vaginal yeast infection while pregnant?

People are more likely to get yeast infections during pregnancy than at other times. If you think you have a vaginal yeast infection during pregnancy, it is important to see your healthcare provider to be sure the infection is yeast before trying to treat it on your own. If you have another kind of vaginal infection, you may need different treatment.

Can miconazole or clotrimazole make it harder for me to become pregnant?

Using miconazole or clotrimazole is not expected to make it harder to become pregnant.

I just found out I am pregnant. Should I stop taking miconazole or clotrimazole?

Talk with your healthcare providers before making any changes to how you take your medication(s).

Does using miconazole or clotrimazole increase the chance for miscarriage?

Miscarriage can occur in any pregnancy. One study found a small increased chance for miscarriage with miconazole and clotrimazole, but there were several problems with this study that could have affected the results. Other studies have not found that miconazole or clotrimazole increases the chance for miscarriage.

Does taking miconazole or clotrimazole increase the chance of birth defects?*

Every pregnancy starts out with a 3-5% chance of having a birth defect. This is called the background risk. Topical (used on the skin) or vaginal medications enter the body in lower amounts than oral (pill) medications. This means less medication reaches the developing baby. Since topical and vaginal miconazole and clotrimazole are not well absorbed, they are unlikely to be a concern for the pregnancy. Most studies have shown that miconazole or clotrimazole at low doses (<400 mg/day) does not increase the chance of birth defects.

Could taking miconazole or clotrimazole cause other pregnancy complications?

No other pregnancy complications or long-term problems in the baby have been identified from using miconazole or clotrimazole.

Can I breastfeed while using miconazole or clotrimazole?

There are currently no studies looking at miconazole or clotrimazole use during breastfeeding. However, because only small amounts of the medication could pass into breastmilk when miconazole or clotrimazole is used on the skin or in the vagina, breastfeeding is not expected to be a concern. Miconazole and clotrimazole creams can be used directly on infants under the care of a healthcare provider to treat fungal infections. Talk to your healthcare provider about your breastfeeding questions.

I take miconazole or clotrimazole. Can it make it harder for me to get my partner pregnant or increase the chance of birth defects? 

There are no studies looking at fertility or possible risks to a pregnancy when the father uses miconazole or clotrimazole. In general, exposures that fathers or sperm donors have are unlikely to increase the risks to a pregnancy.  For more information, please see the MotherToBaby fact sheet Paternal Exposures at https://mothertobaby.org/fact-sheets/paternal-exposures-pregnancy/.

Please click here for references.

*Section updated December 2020

OTIS/MotherToBaby recognizes that not all people identify as “men” or “women.” When using the term “mother,” we mean the source of the egg and/or uterus and by “father,” we mean the source of the sperm, regardless of the person’s gender identity.

View PDF Fact Sheet

90,000 Insidious thrush – Useful articles

Three quarters of women experience thrush, half of them more than once.

It is difficult not to notice it: copious cheesy or white discharge, itching and burning do not give rest. Many women consider it absolutely harmless, and advertising of modern drugs even frees us from the need to go to a gynecologist. Lovely ladies on the TV screen diagnose themselves and prescribe a course of treatment.”Three days, and thrush as it happened!” – they gossip over a cup of tea. Thrush (scientifically “candidiasis”) is really not a dangerous disease. Unless you treat it in the above way.

This is the fault of the yeast-like fungi of the genus Candida, which for the time being quietly – peacefully live in the female genital tract and do not manifest themselves in any way. Yeast-like fungi live in our body from the moment of birth. Getting on the skin of a newborn at the time of its passage through the birth canal of the mother, fungi soon spread throughout the body: they live on the skin and nails, mucous membranes of the mouth, intestines, respiratory and birth canals, and even in the internal organs of a healthy person.Until one day the body fails. Anything can weaken it: stress, hypothermia, illness, a strict diet, hormonal contraceptives, antibiotics. And then the mushrooms, which calmly coexisted with other microflora of the vaginal mucosa, begin to multiply vigorously – candidiasis develops, or simply thrush. Candidiasis does not pose a serious threat to human life and health, however, it leads to unpleasant symptoms. They, in turn, can significantly reduce the quality of life, including intimate relationships.The occurrence of candidiasis may indicate the presence of serious diseases (diabetes mellitus, HIV infection, etc.)

A number of factors contribute to the development of candidiasis:

  • For self-prescribing antibiotics,
  • With weakened immunity (including during pregnancy),
  • For oncological diseases and severe infections (HIV – infection and other infections characterized by suppression of the immune system),
  • Diabetes mellitus,
  • Wearing tight synthetic underwear,
  • Irrational douching,
  • As an occupational disease among workers in the processing of fruits, vegetables, the production of antibiotics, protein – vitamin concentrates and other biologically active substances.

How is candidiasis manifested?

In newborns and seriously ill, as a rule, candidiasis of the oral mucosa develops. In women, whose hands are many and often in the water, candidiasis of the nail folds is usually found. In children and obese people, Candida-like fungi can inhabit the folds of skin in the groin, under the breast, and between the toes. In gynecology, the vaginal form of candidiasis, which is notorious for most women, is treated.

The first symptom is usually a sharp, rapidly growing and becoming almost constant itching in the perineum and vagina.Nature has endowed a woman with a particularly large number of nerve endings in this part of the body, therefore vaginal candidiasis is the most intolerable and causing the greatest number of problems.

Then white plaque appears on the vaginal mucosa and grayish “cheesy” discharge. However, you may simply not notice the discharge, because severe itching calls for increased hygiene measures. A gynecologist will be able to assess the overall picture, so you should not make a diagnosis on your own, only on the basis of already familiar sensations.Moreover, to prescribe a treatment for yourself, as energetic ladies from TV commercials do.


In men, candidiasis is extremely rare: with a decrease in immunity and secondary infections, as part of the general process, when the oral cavity and intestines are affected. It is necessary to treat them, because the fungus can be transmitted through sexual contact (treatment according to the same scheme as in women). As in women, in men, genital candidiasis is manifested by itching, burning, redness and cheesy discharge.”Immaculate” infection with vaginal yeast infection is not the only option. Militant Candida fungi can enter the vagina and the traditional way for many sexually transmitted diseases – with unprotected intercourse.

Is there a mushroom?

Having once consulted a doctor and received instructions on how to overcome thrush, many women follow them again as needed. Such a course of action will help once, twice, three times, but sooner or later the wand will break.After all, the root of the trouble is in the weakening of immunity, and candidiasis is its external manifestation. Therefore, simultaneously with the treatment of thrush, it is necessary to look for and eliminate the cause of immunodeficiency. Without this, candidiasis will appear over and over again. In addition, discharge, itching, and burning may not be all that harmless. The same symptoms are typical for gonorrhea, trichomoniasis, gardnerellosis, genital herpes, chlamydia, mycoplasmosis and other infections. And for their treatment, completely different medicines are required.Most often, to diagnose vaginal candidiasis, smears are taken and, after special staining, they are viewed under a microscope. In addition to fungi, these studies help to identify Trichomonas, gonococci and gardnerella. If necessary, sowing on the medium is done – an extremely accurate analysis that allows you to determine the generic and species belonging of the fungi, and most importantly, their sensitivity to antifungal drugs.


Some gynecologists still prescribe boric acid (borax in glycerin), Castelliani liquid or gentian violet for thrush.These drugs prevent the fungus from attaching to the vaginal wall, inhibit its reproduction, but that’s all. These drugs do not have antifungal effect, therefore, today they are considered ineffective.

There are a lot of modern medicines for the treatment of candidiasis, but you can only trust a doctor, not a friend or advertisement, to choose the right one for you. With a mild course of the disease, as a rule, local treatment is dispensed with, for which drugs of the imidazole group (clotrimazole, isoconazole, econazole, miconazole) and antifungal antibiotics (natamycin, pimafukort, levorin, amphotericin B, nystatin) are selected.

How to ease your lot?

Alas, the easiest way to do this does not suit you – doctors insist on cessation of sexual activity for ten days. Malicious fungi, like cockroaches, temporarily emigrate to your partner’s “living space”, where they will wait quietly (without causing him any noticeable problems) the entire course of treatment, and then again celebrate their return to their native land. It is necessary to observe intimate hygiene as often as possible by adding a furacilin tablet or a spoonful of baking soda to the water.But you should not use a solution of potassium permanganate and soap – with their frequent use, the mucous membrane overdries. After the procedure, you can use talcum powder or baby powder – this will temporarily protect you from the pursuing itching. Eliminate spicy, spicy and pickled foods from the diet – everything that makes the urine too “caustic” and can additionally provoke itching (already of allergic origin). It is better to lean on fresh vegetables, fruits, dairy products, cereals. And in general it is healthier for health.Moreover, the post is in the yard. Avoid for a while from prolonged physical activity, heavy meals and long exposure to heat – anything that leads to profuse sweating, diaper rash and skin irritation.

During menstruation, change your pads more often – every 4-6 hours, regardless of the amount of discharge. Menstrual flow is a suitable breeding ground for pathogenic bacteria, and the immune system is weakened these days. It is better not to use tampons this time.

If thrush responds poorly to treatment and constantly recurs, then they speak of chronic (recurrent) candidiasis and the scheme is changed.Simultaneously with thrush, it is necessary to treat diseases that weaken the body, and it is imperative to strengthen the immune system (if necessary, the doctor prescribes immunomodulators).

But do not forget that no pills can replace a healthy lifestyle: 8-10 hours of sleep, fresh air, fruits – vegetables, vitamins and regular good rest.

Author: Gynecologist Melekhina L.D.

90,000 Thrush in men: treatment, causes, symptoms of candidiasis in men

Men, having found expressed symptoms of candidiasis, often ask themselves the question: “Does thrush in men happen?”In fact, the fungi that cause thrush are present in the normal microflora of the colon and mouth. However, under the confluence of unfavorable circumstances, these fungi begin to multiply actively, which, as a result, leads to the appearance of such an ailment as candidiasis in men.

General information about thrush in men

In the presence of such a disease as thrush in men, the symptoms, treatment and prevention of this ailment depend on how the disease develops.

What is thrush?

Thrush is a type of yeast infection caused by the fungus Candida albicans that can develop in the mouth and throat, skin and genitals. Fungal infections of the genitals are more common in women, but they also occur in men. Mushrooms produce various enzymes (lipotic, proteolytic, sacrolitic) that irritate sensitive nerve endings located on the mucous membrane. The effect of these enzymes on the body explains the clinical signs of thrush in men.

[[doctor text = “Make an appointment with the doctor”]]

Causes of thrush in men

Signs of thrush in men are recorded less often, due to the fact that the Candida fungus is not retained in the body, but is washed out during urination.

The causes of thrush in men are of an endogenous (internal) and exogenous (external) nature of occurrence.

Causes of thrush in men:

  • weakened immunity;
  • poor hygiene;
  • 90,019 receiving a sexually transmitted infection from a woman;

  • long-term or uncontrolled intake of various antibiotics, medications;
  • frequent change of climatic zones;
  • emotional upheavals: the presence of nervous breakdowns, stressful conditions;
  • diabetes mellitus (high blood sugar contributes to the development of a yeast infection).

In addition, in the event of candidiasis in men, the cause of the disease can be “covered” in dysbiosis of the mucous membranes, various dysfunctions of the mucosal barrier that occur due to trauma, inflammation and maceration.

What are the signs of thrush in men?

Thrush in men usually affects the glans of the penis, causing irritation, discharge and redness. The inside of the foreskin may swell. Candidiasis is more common in uncircumcised men.This is because the conditions under the foreskin are favorable for the development of the fungus. Also, when a disease such as thrush in men occurs, the symptoms have characteristic signs for all types of the disease – itching and a whitish coating on the mucous membrane. For an independent visual diagnosis of candidiasis, it is enough to know what a thrush looks like on panties. It leaves characteristic marks – thick, white or slightly yellowish discharge.
Photo of thrush in men (initial stage)

Symptoms of thrush in men

The manifestation of thrush in men depends on what affects the disease.On the skin, candidiasis in men manifests itself in the form of redness and the appearance of bubbles on the skin, and on the mucous membranes – in the form of inflammation of the infectious nature of the oral cavity and urethra.

Symptoms of thrush in men:

  • there is itching, burning sensation on the foreskin, as well as on the glans penis;
  • there is a white discharge from the lesion, resembling cottage cheese;
  • the penis becomes swollen;
  • the discharge has a pungent odor;
  • during urination, white discharge is observed, which outwardly looks like semen;
  • the process of intercourse, as well as urination, is accompanied by pain in the genital area.

When candidiasis is observed in men, the symptoms and treatment of this disease depend on how quickly the incubation period has passed. Basically, this period takes 14-21 days, during which the fungi actively multiply in the body, but still do not give visible symptoms.

How to treat thrush in men

After the first symptoms of thrush appear (listed above), a urologist, as well as a dermatovenerologist, knows how to treat this disease.

If candidiasis is caused by endocrine disorders, treatment is prescribed by an endocrinologist after consultation.

To establish a diagnosis, the patient will need to pass a smear for bacterioscopic examination and bacterial culture. Additionally, the following tests may be prescribed:

  • for the presence of genital infections;
  • blood sugar test;
  • for the Wasserman reaction;
  • general analysis of blood and urine.

If the appearance of thrush has other causes (sugar, infection of the genitals, etc.), then appropriate treatment is carried out by narrow specialists. If only one thrush is found, symptomatic treatment with local preparations for thrush is prescribed.

Thrush occurs in men 4 times less often than in women. Therefore, among the variety of medicinal products for women (creams, gels, ointments, suppositories for thrush, vaginal tablets), only ointments and antifungal tablets are used to treat men.

Among the ointments, the following drugs are distinguished.

Thrush is a disease that requires timely treatment, because there is a risk of complications.

[[doctor text = “Make an appointment with the doctor”]]

If the disease has developed as a result of infection from a sexual partner, then the treatment of thrush in men requires the use of drugs locally, and in some cases internally, by both partners.

If the disease has caused a number of complications, has turned into a chronic form, complex treatment of thrush is required. So, in combination with local drugs, antifungal pills are prescribed. Such an approach in therapy will allow you to get rid of the signs of candidiasis as early as 2-3 days. Such pills for thrush have proven themselves well:

Before using any drug, be sure to consult your doctor!

Diet for thrush

If candidiasis occurs in men, treatment includes not only medication, but also diet.

How to treat thrush in men with diet?

What should be eliminated from the diet?

  • Sweet and flour: sweets, chocolate, sweet fruits, dried fruits, jam, honey, ice cream and other “simple” carbohydrates.
  • Starchy foods , such as sweet pastries, bread. Cut back on potatoes, corn, rice, and similar foods.
  • Marinades , canned food, smoked meats.
  • Some fermented milk products – fermented baked milk, milk, cottage cheese.
  • Fermentation products or those that can cause fermentation and contain live yeast and live fungi. Such products include grapes and other sweet fruits, blue cheeses, kvass, beer, wine, bread, and so on.
  • Certain beverages such as caffeinated coffee and tea, sugar-sweetened beverages and alcohol.
  • Certain types of nuts , including peanuts, pistachios and cashews.
  • Tobacco.

What should be included in the diet?

  • Non-starchy vegetables , including broccoli, Brussels sprouts, cabbage, onions and tomatoes.
  • Fruits with low sugar content such as citrus fruits, olives and berries, but only in moderation.
  • Lean proteins , including chicken, eggs and fish.
  • Healthy fats such as avocado, coconut oil, virgin olive oil and linseed oil.
  • Gluten-free grains such as quinoa, oat bran, buckwheat and rice.
  • Nuts and seeds such as almonds, coconut, flaxseeds and sunflower seeds.
  • Certain dairy products such as butter and ghee, as well as products containing live active crops such as kefir and yogurt (natural).
  • Probiotics.

Sexual intercourse during thrush

Although it is possible for a man with candidiasis to have sex, most doctors do not recommend it until the infection has cleared up.In addition, men can abstain from sexual activity during thrush to minimize pain and itching. Sex during this period not only causes discomfort, but can also cause candidiasis in men to last longer, cause symptoms to return if they have recently passed after treatment, and increase the risk of developing the disease in a partner.

For a more detailed answer to this question, read our article “Is it possible to have sex with thrush.”

Complications of male candidiasis and consequences

If untreated, neglected thrush in men can become chronic, and periodic exacerbations will greatly worsen the quality of life.In case of untimely treatment, the structure of the urethral mucosa may be disturbed, which makes it difficult to urinate, the inflammatory process can rise to the prostate gland and bladder. The sensitivity of the nerve endings of the penis also decreases. With advanced candidiasis, there may be no libido at all and the manifestation of sexual dysfunction. That is why you should promptly diagnose and begin treatment for thrush, without waiting for complications.

Prevention of thrush

Prevention of thrush in men includes the following recommendations:

  1. Strengthen your immune system and health, get enough sleep and try to avoid stress.In addition, it is better to stop drinking alcoholic beverages and smoking.
  2. Observe personal hygiene.
  3. Avoid casual sex and unprotected sex.
  4. Do regular self-examination of the genitals for various changes.
  5. Do not use deodorants, talcum powder, perfumed soaps or shower gels on the genitals. They can be irritating.
  6. Wear loose cotton underwear to avoid creating a moist environment for Candida mushrooms to grow.
  7. Avoid tight underwear and pants / shorts.
  8. Make sure to visit your urologist twice a year. Such visits help to diagnose diseases at an early stage and start timely treatment.

[[doctor text = “Make an appointment with the doctor”]]

Thrush or vulvovaginal candidiasis. Symptoms and treatment

Probably not a single vaginal infection spoils life so much as vulvovaginal candidiasis, or, more simply, thrush. Vulvovaginal candidiasis is an inflammation of the vaginal epithelium caused by fungi of the genus Candida, most commonly Candida albicans. Candida is part of the normal flora in many women and often does not manifest itself in any way. For the development of the disease, the presence of candida in the vagina, as well as the appearance of complaints, is necessary.

Thrush during life is observed in almost every woman. In every 10th it has a chronic course, is difficult to treat. Many women, with the appearance of unpleasant sensations in the vagina, independently undertake treatment attempts, often to no avail, although in most cases completely different microorganisms may be the cause of complaints.

Most often, thrush develops in women taking oral contraceptives, with an increase in their own estrogens (obesity, pregnancy), with diabetes mellitus, decreased immunity, the use of antibiotics.

Currently, it has not been proven that candidal infection is sexually transmitted. The genetic susceptibility of individuals to fungal infection has been proven, so some develop a persistent course of the disease with frequent and persistent symptoms.

Candidiasis is manifested by painful urination, itching, burning, swelling, redness of the vulva, pain during intercourse.Cheesy vaginal discharge appears. Symptoms often appear before menstruation and then disappear. Some women have mild symptoms.

To detect candidiasis, an examination is necessary: ​​bacteriological examination of a smear, culture or PCR diagnostics. But often you can make a diagnosis right at the reception: it is enough to see the characteristic discharge.

What to do if there is a discharge?

You should not delay for a long time with a trip to the gynecologist, because uncomplicated candidiasis is better treated.In 80-90% of cases, a cure occurs with the use of short courses (1-3 days) of antifungal drugs. They are used both in the form of suppositories in the vagina and inside in the form of tablets. Many women resort to self-treatment for thrush because the drugs are readily available and sold without a prescription.

What to do if treatment does not work.

Longer treatment is shown (at least a week). If, after a short course of treatment, complaints remain, or symptoms return within 2 months, an additional examination is necessary.Perhaps another pathogen is the cause of the discharge, or the candida is insensitive to the medication used. Candida is now unresponsive to the commonly used fluconazole.

Should the sexual partner be treated?

There is no evidence that candidiasis is sexually transmitted. If a man is not worried about anything, he does not need to be treated. But sometimes balanitis develops, characterized by redness, itching, irritation of the glans penis. In this case, they are shown antifungal drugs in the form of a cream.

What to do if thrush keeps coming back?

Almost every tenth woman develops recurrent vulvovaginal candidiasis, i.e. four or more cases of the disease within 1 year. Moreover, most of these women have no obvious reason for this. Conventional antifungal medications are often ineffective. Before starting treatment, sowing is necessary to determine the type of pathogen and its sensitivity to drugs. For treatment, long courses (up to 6 months) of therapy are used. Although often after its termination, the symptoms return again.

What should pregnant women do?

Thrush is a common pregnancy companion. It is treated only with vaginal forms of drugs in the form of suppositories.

Is sugar consumption associated with the development of thrush?

  • ⠀ There is no evidence that sugar intake is associated with thrush, although there is still evidence that lowering dietary sugar may reduce candidiasis.
  • ⠀ This also applies to products containing starch, i.e. made from premium flour.These are pasta, bread, cookies and other flour products. There is no evidence of their effect on the development of fungal diseases.
  • ⠀ And regarding the popular misconception that foods containing yeast contribute to the development of candidiasis. Vulvovaginal candidiasis is most commonly caused by Candida albicans. The type of yeast used to make bread and brew beer is called Saccharomyces cerevisiae, and it rarely causes infections.

Therefore, you should adhere to the golden mean: limit the consumption of refined carbohydrates, but not give up them altogether, because this, most likely, will not get rid of candidiasis.

Can Probiotic Products Prevent or Cure Candidiasis?

  • ⠀ To prevent infection, including after treatment of candidiasis, it is possible to use probiotics, especially when the number of lactobacilli in the vagina is reduced. But with normal indicators of lactobacilli, the use of probiotics does not make sense.
  • ⠀ But probiotics are not enough to treat an already onset disease. For treatment, antifungal drugs are used in the form of tablets or vaginal suppositories.

Does intimate hygiene affect the development of thrush?

  • ⠀ If you have thrush, do not use soap, scented shower gels, or panty liners. They create the effect of a sauna and contribute to excessive moisture in the skin of the external genital organs, which is an excellent medium for candida growth.
  • ⠀ What you can do: shower instead of bath, intimate hygiene product with lactic acid and acidic pH. Loose cotton underwear.During the period of acute infection, it is possible to have sex with a condom until cured.

PIMAFUCIN instructions for use, price in pharmacies in Ukraine, analogues, composition, indications | PIMAFUCIN of LEO Pharma

pharmacodynamics. Natamycin is a broad-spectrum polyene antibiotic, active against pathogenic fungi, including yeasts and especially Candida albicans , which are most often the cause of genital tract infections.Acts fungicidal, binding sterols of cell membranes, violates their integrity, causing the death of microorganisms.

The drug does not exhibit sensitizing activity. There were no cases of allergy to natamycin during treatment or during its industrial production, and there was no development of resistance to it.

Due to its enteric coating, the tablet acts only in the intestine.

The drug quickly and effectively acts in case of vaginal yeast infection (candidiasis).Vaginal suppositories also have a therapeutic effect in the presence of vaginal discharge, inflammation and itching, including the upper, less accessible parts of the vagina. The drug quickly melts in the vagina, forming a foamy mass, which contributes to the even and complete distribution of the active substance over its entire surface.

Pharmacokinetics. When taken orally in the form of tablets, natamycin is practically not absorbed in the gastrointestinal tract.

The existing methods failed to detect natamycin, used intravaginally, and its derivatives in the blood and biological fluids of the body, which indicates the absence of a systemic effect of the drug.

Natamycin is active when applied topically and is not absorbed through the skin and mucous membranes.

tablets. For the treatment of intestinal candidiasis, adults are prescribed 1 tablet 4 times a day. Typically, therapy lasts 1 week.

Children aged 3 years and older are prescribed 1 tablet 2 times a day. Due to the peculiarities of the pharmacodynamic and pharmacokinetic properties of natamycin, the same dose is recommended for children of all ages. Usually the duration of treatment is 1 week.

Suppositories. Used in adult women, 1 suppository for 3-6 days. Suppositories are recommended to be inserted as deeply as possible into the vagina (in the supine position) once a day (at night). If it is necessary to carry out treatment for several days, the course of therapy should be completed before the onset of menstruation or treatment should be started after it ends.

Cream is applied to the affected skin 1–4 times a day every day. The duration of therapy is usually 2-3 weeks.

hypersensitivity to the components of the drug.


From the gastrointestinal tract: nausea and diarrhea are possible (which occur in the first days of use and disappear on their own during treatment).

Possible hypersensitivity reactions.

Suppositories : rare (> 0.01%, <0.1%)

Skin and subcutaneous tissue: hypersensitivity reaction, burning sensation and irritation.


Organ systems Rarely (≥1 / 10,000, <1/1000)
General disorders and reactions at the injection site Hypersensitivity reactions, burning sensation, irritation

Hypersensitivity reactions : Some irritation or burning sensation may occur at the site of application. If they continue, this may be due to hypersensitivity to preservatives (parahydroxybenzoates).The presence of methyl parahydroxybenzoate and propyl parahydroxybenzoate in the preparation may cause allergic reactions (possibly delayed).

the use of natamycin in the form of tablets may be associated with the development of an acute attack of porphyria, therefore, the use of the drug is considered unsafe for patients with this disease.

Since the drug in the form of tablets contains lactose, it should not be used in patients with rare hereditary forms of galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome.

The preparation contains sucrose, which should be taken into account in patients with diabetes mellitus. Since the drug contains sucrose, it should not be used in patients with rare hereditary diseases, such as fructose intolerance or sucrase-isomaltase deficiency.

During menstruation, treatment with Pimafucin ® in the form of vaginal suppositories should be interrupted. During drug therapy, there is no need to avoid sexual intercourse.

Pregnancy and breastfeeding .Pimafucin ® can be prescribed during pregnancy and lactation.

Children . Natamycin in the form of coated tablets is used in children over the age of 3 years; in the form of a cream – in children of all age groups; in the form of vaginal suppositories – not used in children.

The ability to influence the reaction rate during driving and working with other mechanisms .Does not affect.

no messages. When using vaginal suppositories, a systemic effect is practically excluded, since the drug is not absorbed through the mucous membrane.

at a temperature not exceeding 25 ° C.

Mycoses are a complex problem and occupy a large niche in the segment of opportunistic infections. Opportunistic pathogens are those that are not able to infect a person with a healthy immune system and cause disease only under certain conditions (violation of natural defense mechanisms).At the present stage, the frequency and severity of fungal infections, especially with a chronic course, are sharply increasing. This is due to the development of other areas of medicine: new surgical interventions, active development of antibiotic therapy and hormone therapy, chronicity of the course of various immunodeficiency states, both of infectious origin (Protsenko O.A., 2006), and as a result of regular intake of immunosuppressive drugs. In addition, the variety of yeast-like fungi, different in their specific properties, makes it difficult to treat the diseases they cause.Fungi of the genus Candida are a serious medical problem. Statistics show that the frequency of asymptomatic carriage of Candida in the intestine reaches 65–80% of healthy people, and in the vagina – 15–20% of women during the period when they are not pregnant. At the same time, the impact of many exo- and endogenous factors can lead to the transformation of candidacy into a clinically expressed disease (Karapetyan T.E., 2014).

The pronounced tendency to the spread of candidiasis necessitates the selection of safe and effective drugs that allow the therapy to be carried out repeatedly or in long courses with minimal systemic drug load on the body.Such a drug is Pimafucin . This medication is available in 3 dosage forms: suppositories, cream and tablets. Each of these forms meets the individual needs of patients with different forms of candidiasis.

How it works


Natamycin is used as an active ingredient in the preparation Pimafucin . It is a broad-spectrum polyene antibiotic from the macrolide group (Gabdullina L.R., 2012), and is active against pathogenic fungi (instruction of the Ministry of Health of Ukraine). In studies in vivo and in vitro , it was found that most strains of Candida albicans are sensitive to natamycin (O`Day D.M., 1987). In addition, pathogens such as Curvularia spp are susceptible to the drug. , Fusarium spp. , Aspergillus spp. , and the antifungal effect is potentiated by the combined use of natamycin with voriconazole (Sradhanjali S., 2018). In addition, in vitro the antileishmania activity of the drug was established – it disrupts the energy metabolism of promastigotes, increases the level of cytosolic calcium and causes other changes leading to the death of the pathogen. And although at the moment it is not included in the treatment protocols, scientists insist on its promise and safety (Awasti B.P., 2018). There is information (Lobko S.S., 2016) about the anti-trichomonas activity of natamycin.

The mechanism of the fungicidal action of natamycin is realized due to the binding of sterols of cell membranes (in particular ergosterol) and disruption of their integrity, which leads to the loss of cell ions and macromolecules and, ultimately, to the death of microorganisms (Lobko S.S., 2016). Natamycin is superior to chlorhexidine in its fungicidal activity (Dos Santos C.O., 2019). The action of natamycin is potentiated by timolol and 5-fluorouracil (Rees A.A., 2019).

The positive characteristics of the drug include the lack of resorptive action – it is not absorbed by the mucous membranes or skin. According to the manufacturer, to date it has not been possible to identify traces of the drug or its metabolites in the blood during intravaginal use. Also, there is no information on registered cases of allergy to natamycin or other manifestations of its sensitizing activity (instruction of the Ministry of Health of Ukraine).

Under industrial conditions, natamycin is produced by the line Streptomyces chattanoogensis L10 as a secondary metabolite (Wang K., 2019).

Indications for use


Pimafucin is intended for the treatment of various lesions caused by Candida albicans (instruction of the Ministry of Health of Ukraine):

    tablet form is used for the treatment of fungal lesions of the gastrointestinal tract; vaginal suppositories are intended for the treatment of candidal vaginitis; the cream is used for candidal lesions of the skin and its appendages.

Clinical experience with


In a double-blind clinical study, the effectiveness of Pimafucin was demonstrated in the treatment of candidal stomatitis. Already within the first week of the course of treatment, there is a significant decrease in the growth rate of the pathogen and a decrease in the number of colony-forming units (Koopmans A.S., 1984). Tableted natamycin is considered the drug of choice for the prevention of candidal stomatitis in children receiving chemotherapy for cancer (Hoppe J.E., 1995).

Vaginal suppositories Pimafucin can effectively treat vaginal inflammation associated with Trichomonas vaginalis , Leptothrix vaginalis or Candida albicans . When the drug is combined with metronidazole (administered orally) after the first course of treatment, successful eradication, depending on the type of pathogen, is achieved in 79–96.1% of patients (Toth B., 1975). According to studies, the effectiveness of treatment of vaginal candidiasis Pimafucin is about 81% in pregnant women and 86% in non-pregnant women (Chazan B., 2000). Simultaneously with the woman, it is recommended to treat her partner at the same time (Buch A., 1982). Natamycin in the form of a cream is also suitable for the treatment of anal or genital (balanoposthitis) candidiasis in men (Masteron G., 1975). The advantage of Pimafucin is that during the course of treatment it is not required to avoid sexual intercourse (instruction of the Ministry of Health of Ukraine).

There is a patented method for treating bacterial vaginosis Pimafucin . Bacterial vaginosis is a non-inflammatory infectious syndrome associated with a complex of pathological changes in the urogenital microbiota: active proliferation of obligate and facultative microflora with suppression of lactoflora. Therapy with Pimafucin allows achieving clinical and etiological cure in 92.3% of cases, that is, it is highly effective.In addition, such monotherapy can reduce the drug load on the body in the presence of a mixed infection. The drug does not have an inhibitory effect on the indigenous urogenital microflora, which makes it possible to avoid the development of dysbiotic processes and eliminates the need to correct the vaginal microflora with biotherapeutic drugs (Lipova E.V., 2005). Pimafucin in combination with antiviral and immunomodulatory drugs is used in the complex therapy of candida-herpetic urogenital infection (Garbuzov D.O., 2006).

Pimafucin in combination with dimethyl sulfoxide and sodium benzoate is an effective drug against onychomycosis caused by Aspergillus terreus (Onsberg P., 1978). Pimafucin for external use does not have a resorptive effect, and this is its great advantage, since the treatment of some mycoses, for example, onychomycosis caused by Scopulariopsis brevicaulis , requires long-term treatment with natamycin – the course is 3-5 months (Onsberg P …, 1980), and in such conditions, the non-toxicity of the drug is extremely important.

Natamycin has proven itself in combustiology practice. It prevents the colonization of the skin flap, which is used to replace a large traumatic defect, with fungi such as Aspergillus fumigatus or Aspergillus niger (Bauer U., 1975).

Pimafucin is used in pediatric dermatological practice.It allows you to effectively treat candidiasis of the skin and mucous membranes, especially in children with atopic dermatitis (Kaliuzhnaia L.D., 1997). Pimafucin is also used to treat microbial eczema – this is due to the frequent association of Staphylococcus aureus and Candida spp. (Sokolova T.V., 2006). Clinicians point to the possibility of using Pimafucin for the treatment of candidiasis of large skin folds – a frequent pathological process accompanying excess body weight (Sokolova T.IN 2014).

The literature describes the experience of treating bronchopulmonary aspergillosis, in particular aspergilloma, using irrigation of the cavity with a suspension of natamycin (Henderson A.H., 1968). Pimafucin is not suitable for preparing a suspension and, accordingly, for irrigating the respiratory tract. However, existing forms of the drug can be used to treat more superficial foci of aspergillosis. For the most effective eradication of the pathogen, natamycin is recommended to be combined with amphotericin B and ketoconazole (Rafferty P., 1983).

Research results demonstrate that the use of oral forms of natamycin for the treatment of intestinal candidiasis does not always achieve the expected therapeutic effect – with monotherapy with the drug for 10 days, according to fecal analysis, yeast eradication is observed in about 20% of cases. However, the addition of butylscopolamine to the treatment regimen significantly improves the short-term results of treatment (Gehring W., 1990). The criterion for the diagnosis of intestinal candidiasis and the method of confirming its cure is the identification (after the course of treatment – disappearance) of filamentous pseudomycelium in biopsies of the intestinal mucosa (Zlatkina A.R., 2005). Pimafucin can be recommended as a drug for the treatment of antibiotic-associated diarrhea if its cause is confirmed invasive candidiasis (Luzina E.V., 2009).

Pimafucin has established itself as an effective drug for the treatment of patients with ulcerative colitis. Since these patients are systematically receiving glucocorticosteroid therapy, they have an increased risk of colonization of the intestine with micromycetes. This is facilitated by cytotoxic chemotherapy, decreased peristalsis, and primary intestinal damage.That is why in 90-100% of patients with ulcerative colitis, intestinal microflora disorders with the development of chronic candidiasis are observed. However, after the course of taking Pimafucin inside, about 87% of patients note a therapeutic effect, both according to clinical criteria and subjective: manifestations of intestinal dyspepsia, reduction of skin and perianal itching, etc. (Avalueva E.B., 2009).

An interesting indication for the use of Pimafucin is esophageal candidiasis in GERD (Osadchuk A.M., 2010).

A case of observation in a patient of a mycotic bezoar, which was formed by a colony Geotrichum candidum against the background of decreased gastric secretion and migrated into the small intestine with the development of high intestinal obstruction, is described in the literature. Treatment included mechanical destruction of the bezoar with biopsy forceps, as well as taking natamycin for 5 weeks to prevent relapse (Goszcz A., 1989).

Application features


After applying the drug to the affected skin, avoid direct sunlight, since natamycin undergoes photodeactivation (Thoma K., 1997).

In a population-based study, it has been reliably demonstrated that the vaginal use of natamycin preparations during pregnancy is not associated with teratogenic effects on the fetus (Czeizel A.E., 2003). Pimafucin in the form of vaginal suppositories is approved for use during pregnancy and lactation, and in the form of a cream – for children of any age. The tablet form of the drug is used in children from the age of 3 (instructions of the Ministry of Health of Ukraine).


Pimafucin has found application in gynecological, dermatological and gastroenterological practice. This is a drug that acts exclusively locally and does not have a systemic effect, and therefore can be used in patients of any category with practically no restrictions. Modern forms of release make it convenient for independent use on an outpatient basis. In addition, the wide spectrum of action of natamycin makes it effective not only against various forms of candidiasis, but also against other, more rare mycoses.

Candidiasis or thrush

Candidiasis occurs due to yeast-like fungi of the genus Candida. Although these microorganisms are part of the normal microflora of the vagina, mouth and colon, their excess and proliferation is a disease. An exacerbation of candidiasis can occur with a decrease in immunity.

Candidiasis infection

Although transmission of pathogens of candidiasis is possible sexually, most often candidiasis is not associated with sexual intercourse. Candidiasis is not a sexually transmitted disease, although it has similar clinical manifestations, therefore it can often be suspected in conjunction with other diseases.

Factors contributing to the development of candidiasis:

– taking a course of broad spectrum antibiotics;

– decrease in general immunity, including due to climate change or stress;

– pregnancy, especially in the last trimester;

– diabetes mellitus;

– HIV infection.

The likelihood of the risk of candidiasis as a result of wearing tight underwear is a misconception.


In women, the disease affects the external genital organs and the vagina, in men – the head of the penis and the foreskin.

Symptoms in women:

– itching and burning in the external genital area;

– vaginal discharge – white, curd in composition;

– pain during urination and / or intercourse;

Symptoms in men:

– itching and burning near the glans penis and foreskin;

– redness of the foreskin and glans;

– the appearance of white plaque on the head of the penis;

– pain during urination and / or intercourse;

Diagnosis of candidiasis

Light microscopy and the clinical picture of the disease are used to diagnose candidiasis.Detection of Candida fungi occurs during sowing, by the method of immunofluorescence (PIF) and by the method of DNA diagnostics (PCR), just the presence of this type of fungi is not a confirmation of the disease, their quantity is important. Since these mushrooms are present in small quantities in all healthy people.

Treatment of candidiasis in men

Treatment of candidal balanoposthitis (lesions of the glans penis and foreskin) is treated topically, namely with a cream containing clotrimazole. It must be applied in a thin layer to the head of the penis and foreskin for 5-7 days, 2 times a day.

Additionally, the doctor may prescribe a single oral dose of fluconazole. The commercial names of this drug are Medoflucon, Forcan, Diflucan, Diflazon, Mikosist, Flucostat.

Treatment of candidiasis in women

In women, the treatment of candidiasis is very individual, therefore, a doctor’s consultation is necessary, for treatment they use topical drugs – vaginal tablets and suppositories. It is not advisable to use vaginal tablets and suppositories of a wide spectrum of action, since such drugs contribute to the development of gardnerellosis, the antibacterial agents that are part of the drugs suppress the normal microflora of the vagina.

Thrush in men

How to get to the medical center

1st Nagatinsky proezd, 14.

from metro Nagatinskaya:

Exit # 4 from the metro station, bus stop “Metro Nagatinskaya”. Bus 142 to the stop 1-y Nagatinsky proezd. Cross the road, walk along the Post Office and Western Union along the Projected Passage. Exit to 1st Nagatinskiy proezd. On the left there will be a large red building with a balcony, go up to the balcony, there will be a sign “ElKlinik”.

from metro Prazhskaya:

From the Prazhskaya metro station, go to the Nagatinskaya metro station.

Exit 5 from the metro station. Trams: 3, 16 to the stop 1st Nagatinsky proezd.

From the metro exit No. 4, bus stop “Metro Nagatinskaya”, bus t8 to the stop 1-y Nagatinskiy proezd.

from metro Anino:

Exit 4 from the metro station. Walk to the Metro Anino bus stop, take bus t40 to the stop 1-y Nagatinskiy proezd.

Yuzhnaya metro station:

From the Yuzhnaya metro station, get to the Nagatinskaya metro station.

From the metro exit No. 4, to the bus t8, or exit No. 5 to trams 3, 16. To the stop 1-y Nagatinskiy proezd.

from Varshavskaya metro station:

From the metro go to the bus stop and buses t40, 142, t8 to the stop “1st Nagatinskiy proezd”.

from Nagornaya metro station:

From the Nagornaya metro station, get to the Nagatinskaya metro station. Exit 4 to buses t8, 142, n8 (night), t40, or exit 5 to trams 3, 16 to the stop “1st Nagatinskiy proezd”.

from Tulskaya metro station:

Exit 2 from the metro, cross Bolshoi Starodanilovsky lane, on the left there will be a Rigla pharmacy and a chain of stores. Go through the park to the Danilovskaya chapel, turn right and get off at the Serpukhovskaya Zastava tram stop. Take the 3rd tram, get to the stop “1st Nagatinskiy proezd”.

from Tsaritsyno metro station:

From Tsaritsyno, get to the Kashirskaya metro station, walk to the bus stop. Take bus t71, get to the stop “1st Nagatinskiy proezd”.

from metro Orekhovo:

From the Orekhovo metro station, get to the Kashirskaya metro station, exit No. 4, turn right, go through the monument to G.K. Zhukov, walk to the bus stop. Take bus t71, get to the stop “1st Nagatinskiy proezd”.

from metro Domodedovskaya:

Exit 12 from the metro, there will be a bus stop on the left. Take bus t71. Get to the stop “1st Nagatinskiy proezd”.

from Chertanovo railway station:

From the station, cross the road, walk along the Projected passage to Dorozhnaya Street, turn left, walk to the bus stop “Center for Martial Arts”.Buses: 683, 225, 241. Get to the stop “Metro Varshavskaya”. Cross the road, go to the bus stop and buses t40, 142. Get to the stop 1-y Nagatinskiy proezd.

from Kolomenskaya metro station:

From the metro, cross the road and walk Beeline and Unistream to the Kolomenskaya metro stop. Take tram 47, 49, get to the Yuvelirny Zavod stop. Turn left towards Projected Passage, walk along the Medical Center and Investigation Department, and pass Dixie.Go around the residential building and walk along the Projected passage until the traffic light. Cross the road to the large red building (house 14) with a balcony. Climb to the balcony, there will be a sign “ElKlinik”.

Exit 7 from the metro station, to the bus stop “Metro Kolomenskaya”. Buses: 751, 351. Get to the stop “Nagatinskaya embankment, 10”. Walk along the embankment to the Tatneft gas station and the barrier. Walk to the residential building and turn left. Get off at 1st Nagatinsky passage. Go through the Glafira coffee shop to the traffic light.Cross the road. Walk forward and exit to a large red building (house 14) with a balcony. Climb to the balcony, there will be a sign “ElKlinik”.

Exit 5 from the metro, there will be a bus stop on the right. Buses: 901, 299, 608, t71. Get to the stop “1st Nagatinskiy proezd”. Pass Pyaterochka (will be on the left), turn left towards the Post Office and Western Union, go straight along the Projected passage. Exit to 1st Nagatinskiy proezd. On the left there will be a large red building with a balcony, go up to the balcony, there will be a sign “ElKlinik”.

from Technopark metro station:

From the Technopark, get to the Kolomenskaya metro station, exit №1, go through the French pastry, get off at the tram stop. Take tram 47, 49, get to the Yuvelirny Zavod stop. Turn left towards Projected Passage, walk along the Medical Center and Investigation Department, and pass Dixie. Go around the residential building and walk along the Projected passage until the traffic light. Cross the road to the large red building (house 14) with a balcony. Climb to the balcony, there will be a sign “ElKlinik”.

from Avtozavodskaya metro station:

From the Avtozavodskaya metro station, get to the Kolomenskaya metro station, exit No. 1, go through the French pastry, get off to the tram stop. Take tram 47, 49, get to the Yuvelirny Zavod stop. Turn left towards Projected Passage, walk along the Medical Center and Investigation Department, and pass Dixie. Go around the residential building and walk along the Projected passage until the traffic light. Cross the road to the large red building (house 14) with a balcony.Climb to the balcony, there will be a sign “ElKlinik”.

90,000 Thrush. Answers to awkward questions

Almost all women at least once in their lives have encountered unpleasant symptoms of thrush. However, many are still hesitant to ask a doctor about treatment for this problem. Therefore, today the gynecologist at the VitaLine clinic in Vinogradar will help you understand the most popular questions about thrush and tell you how to treat it.

What causes thrush?

The development of thrush is provoked by fungi from the genus Candida.That is why thrush is also called candidiasis. Although these fungi do not belong to the pathogenic microflora, under certain conditions their number begins to grow rapidly, and that is why the characteristic symptoms of the disease appear. Such processes can be triggered by various reasons, in particular, taking antibiotics, stress, unhealthy diet, and so on.

What are the first symptoms of thrush?

Thrush makes itself felt by redness and itching of the skin of the genitals, aggravated after contact with water.Discomfort during sex and urination may also occur. But, above all, a symptom of thrush is abundant odorless white discharge.

Is thrush a STD?

Thrush is not considered a sexually transmitted disease, since the activation of candidal fungi can occur even in the body of women who are not sexually active. But, nevertheless, the partner can become infected during intercourse (including oral). Therefore, during the period of treatment for thrush, it is better to abstain from sex or at least use barrier methods of contraception.If an infection has occurred, partners need to be treated at the same time.

How is thrush treated?

When symptoms of thrush appear, you should consult a doctor, if only because only in this case you can be sure that this is really candidiasis, and not a manifestation of any other disease.

After the examination, the doctor will select an effective treatment that will allow you to get rid of discomfort as quickly as possible. Most often, women are prescribed antifungal medications in the form of suppositories, and their partners can use a cream with similar properties.Also, the doctor may suggest taking medications in the form of pills.

Don’t worry if you notice symptoms of thrush. It can be easily, quickly and effectively treated. Consult a doctor in time, who will offer a comprehensive treatment that allows you to cope not only with the symptoms, but also with the cause of the problem.