What are the uses of Zofran ODT. How does ondansetron work to prevent nausea and vomiting. What are the common side effects of Zofran ODT. How should Zofran ODT be taken for maximum effectiveness.

Understanding Zofran ODT: A Powerful Antiemetic Medication

Zofran ODT, also known as ondansetron orally disintegrating tablet, is a widely prescribed medication used to prevent nausea and vomiting associated with various medical treatments. As a member of the antiemetic drug class, Zofran ODT plays a crucial role in improving patient comfort and treatment adherence. This article delves into the various aspects of Zofran ODT, including its uses, mechanism of action, potential side effects, and important considerations for patients and healthcare providers.

The Versatility of Zofran ODT: Applications in Medical Treatments

Zofran ODT is primarily used to combat nausea and vomiting caused by certain medical interventions. These include:

• Chemotherapy
• Radiation treatments
• Surgery

Its effectiveness in managing these symptoms makes it an invaluable tool in oncology, post-operative care, and other medical fields where nausea and vomiting can significantly impact patient well-being and treatment outcomes.

How does Zofran ODT differ from other forms of ondansetron?

Ondansetron is available in multiple formulations, including:

1. Oral tablets
2. Orally disintegrating tablets (ODT)
3. Oral solution
4. Intravenous (IV) form

The ODT formulation offers a convenient option for patients who may have difficulty swallowing traditional tablets, as it quickly dissolves on the tongue without the need for water. This can be particularly beneficial for patients experiencing severe nausea or those with swallowing difficulties.

The Science Behind Zofran ODT: Mechanism of Action

Ondansetron, the active ingredient in Zofran ODT, belongs to a class of drugs called antiemetics. These medications work by reducing nausea and vomiting through specific mechanisms in the body. But how exactly does ondansetron accomplish this?

Ondansetron functions by blocking the release of serotonin in two key areas:

• The gut
• The central nervous system

By inhibiting serotonin release, ondansetron prevents this neurotransmitter from triggering the nausea and vomiting reflex. This targeted approach makes Zofran ODT highly effective in managing these symptoms, particularly in the context of medical treatments known to induce nausea and vomiting.

Navigating the Side Effects: What Patients Should Know

While Zofran ODT is generally well-tolerated, it’s essential for patients to be aware of potential side effects. These can range from mild to severe, and understanding them can help patients make informed decisions about their treatment.

Common Side Effects of Zofran ODT

The more frequently reported side effects of ondansetron include:

• Headache
• Diarrhea
• Constipation
• Dizziness
• Drowsiness

These side effects are typically mild and often resolve on their own within a few days or weeks. However, if they persist or become bothersome, patients should consult their healthcare provider for guidance.

Are there any serious side effects associated with Zofran ODT?

While rare, some serious side effects can occur with Zofran ODT use. The most significant of these is serotonin syndrome, a potentially life-threatening condition characterized by an excess of serotonin in the body. Symptoms of serotonin syndrome may include:

• Agitation
• Hallucinations
• Rapid heartbeat
• Sweating
• Muscle rigidity
• Tremors
• Nausea and vomiting
• Diarrhea
• In severe cases, coma

Patients experiencing any of these symptoms should seek immediate medical attention. It’s important to note that while serotonin syndrome can occur with ondansetron alone, the risk is heightened when combined with other medications that affect serotonin levels.

Dosage and Administration: Optimizing Zofran ODT Effectiveness

Proper administration of Zofran ODT is crucial for maximizing its effectiveness and minimizing potential side effects. The dosage and frequency of administration can vary based on the specific medical treatment and individual patient factors.

How should Zofran ODT be taken?

Zofran ODT is designed to dissolve quickly on the tongue, making it easy to take without water. To use the orally disintegrating tablet:

1. Peel back the foil packaging to remove the tablet
2. Place the tablet on the tongue immediately
3. Allow it to dissolve completely before swallowing
4. Do not chew or swallow the tablet whole

It’s important to take Zofran ODT exactly as prescribed by your healthcare provider. The timing of doses may be critical, especially when used to prevent nausea and vomiting associated with chemotherapy or radiation treatments.

Drug Interactions: Ensuring Safe Use of Zofran ODT

Like many medications, Zofran ODT can interact with other drugs, potentially altering its effectiveness or increasing the risk of side effects. Understanding these interactions is crucial for both patients and healthcare providers to ensure safe and effective treatment.

Which drugs should not be taken with Zofran ODT?

Some medications should be avoided when taking Zofran ODT due to the risk of dangerous interactions. One notable example is apomorphine, a drug used to treat Parkinson’s disease. Combining apomorphine with ondansetron can cause a dangerous drop in blood pressure, potentially leading to fainting or other serious complications.

Can other medications increase the risk of side effects from Zofran ODT?

Certain medications can increase the concentration of ondansetron in the body, potentially raising the risk of side effects. These may include drugs that affect the liver enzymes responsible for metabolizing ondansetron. Patients should always provide their healthcare provider with a complete list of all medications, supplements, and herbal products they are taking to avoid potential interactions.

Special Considerations: Pregnancy, Breastfeeding, and Pediatric Use

The use of Zofran ODT in special populations, such as pregnant women, breastfeeding mothers, and children, requires careful consideration and should be guided by a healthcare professional.

Is Zofran ODT safe during pregnancy?

The safety of ondansetron during pregnancy has been a subject of ongoing research and debate. While it has been used to treat severe morning sickness (hyperemesis gravidarum) in some cases, recent studies have raised concerns about potential risks to fetal development. Pregnant women should discuss the potential benefits and risks with their healthcare provider before using Zofran ODT.

Can Zofran ODT be used while breastfeeding?

Ondansetron does pass into breast milk in small amounts. While the effects on nursing infants are not well-studied, most experts consider it to be compatible with breastfeeding when used as directed. However, breastfeeding mothers should consult their healthcare provider for personalized advice.

How is Zofran ODT used in pediatric patients?

Zofran ODT is approved for use in children for certain indications, such as preventing nausea and vomiting associated with chemotherapy. However, dosing may differ from adult recommendations, and the safety and efficacy in very young children may not be established for all uses. Pediatric use should always be under the guidance of a qualified healthcare professional.

Maximizing the Benefits of Zofran ODT: Tips for Patients

To get the most out of Zofran ODT treatment and minimize potential issues, patients can follow these helpful tips:

• Take the medication exactly as prescribed, paying attention to timing and dosage
• Inform your healthcare provider of all other medications and supplements you’re taking
• Report any side effects or unusual symptoms promptly
• Keep Zofran ODT stored properly, away from moisture and direct light
• Consider keeping a symptom diary to track the medication’s effectiveness
• Stay well-hydrated, especially if experiencing diarrhea as a side effect
• Avoid alcohol, as it may increase the risk of certain side effects

By following these guidelines and maintaining open communication with their healthcare provider, patients can optimize their experience with Zofran ODT and effectively manage nausea and vomiting associated with various medical treatments.

Side Effects, Dosage, Uses, and More

Highlights for ondansetron

1. Ondansetron orally disintegrating tablet is available as a brand-name drug and as a generic drug. Brand name: Zofran ODT.
2. Ondansetron comes in three forms that you take by mouth: a tablet, a disintegrating tablet, and a solution. It’s also available in an intravenous (IV) form. This form is only given by a healthcare professional.
3. Ondansetron orally disintegrating tablet is used to prevent nausea and vomiting caused by certain medical treatments.

• Serotonin syndrome warning: Ondansetron raises your risk of a life-threatening condition called serotonin syndrome. This syndrome occurs when the chemical serotonin builds up too much in your body. A high level of serotonin can cause agitation, delirium (confused thinking) and hallucinations (seeing or hearing things that aren’t real). It can also cause sweating, rapid heartbeat, muscle stiffness, tremor, seizures, jerky muscle movements, and coma. Call your doctor right away if you have any of these symptoms. This condition can result from using ondansetron alone. However, it’s more likely to occur when you’re also taking another drug that affects serotonin levels.

Ondansetron is a prescription drug. It comes in three forms that you take by mouth: a tablet, a disintegrating tablet, and a solution. It’s also available in an intravenous (IV) form, which is only given by a healthcare professional.

Ondansetron orally disintegrating tablet is available as the brand-name drug Zofran ODT. It’s also available as a generic drug. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in every strength or form as the brand-name drug.

Ondansetron may be used as part of a combination therapy. This means you may need to take it with other medications.

Why it’s used

Ondansetron orally disintegrating tablet is used to prevent nausea and vomiting caused by certain medical treatments. These treatments include:

• chemotherapy
• radiation treatment
• surgery

How it works

Ondansetron belongs to a class of drugs called antiemetics. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions. Antiemetics are drugs that reduce nausea and vomiting.

Ondansetron works by blocking the release of the chemical serotonin in the gut and the central nervous system. This keeps serotonin from causing nausea and vomiting.

Ondansetron orally disintegrating tablet may cause drowsiness. It can also cause other side effects.

More common side effects

The more common side effects of ondansetron can include:

• headache
• diarrhea
• constipation
• dizziness
• drowsiness

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

• Serotonin syndrome. Symptoms can include:
  • agitation
  • hallucinations (seeing or hearing things that aren’t real)
  • rapid heartbeat
  • sweating
  • feeling hot
  • muscle rigidity (stiffness)
  • tremor
  • nausea
  • vomiting
  • diarrhea
  • coma

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare professional who knows your medical history.

Ondansetron orally disintegrating tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Examples of drugs that can cause interactions with ondansetron are listed below.

Drugs you should not use with ondansetron

Do not take these drugs with ondansetron. Doing so can cause dangerous effects in your body. Examples of these drugs include:

• Apomorphine. Taking this drug with ondansetron can cause your blood pressure to drop to unsafe levels. This can cause you to pass out.

Interactions that increase your risk of side effects from ondansetron

Taking ondansetron with certain medications raises your risk of side effects from ondansetron. This is because the amount of ondansetron in your body may be increased. Examples of these drugs include:

• Other drugs that affect serotonin levels, such as fluoxetine and paroxetine.

Interactions that can make ondansetron less effective

Taking these drugs with ondansetron can make ondansetron less effective. This is because the amount of ondansetron in your body may be decreased. Examples of these drugs include:

• Anti-seizure drugs, such as phenytoin or carbamazepine. Your doctor may switch you from ondansetron to a different drug if needed.
• Tuberculosis drugs, such as rifampin, rifabutin, or rifapentine. Your doctor may switch you from ondansetron to a different drug if needed.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare professional about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

This drug comes with several warnings.

Allergy warning

Ondansetron can cause a severe allergic reaction. Symptoms can include:

• flushing
• trouble breathing
• swelling of your throat or tongue
• dizziness
• coughing

If you develop these symptoms, call 911 or go to the nearest emergency room.

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

Warnings for people with certain health conditions

For people with risk factors for heart arrhythmias: If you have conditions such as heart failure or congenital long QT syndrome, this drug may increase your risk of arrhythmias. Ask your doctor if you have risk factors for arrhythmias.

For people with phenylketonuria: The ondansetron orally disintegrating tablet contains phenylalanine. This amino acid can cause dangerous effects in people with a condition called phenylketonuria. Don’t take the orally disintegrating tablet if you have phenylketonuria.

Warnings for other groups

For pregnant women: There haven’t been enough studies done in humans to be certain how ondansetron might affect a fetus when the mother takes it. Research in animals has not shown a risk to the fetus. However, animal studies do not always predict the way humans would respond.

Talk to your doctor if you’re pregnant or planning to become pregnant. This drug should only be used in pregnancy if clearly needed.

For women who are breastfeeding: Ondansetron may pass into breast milk and may cause side effects in a child who is breastfed. Talk to your doctor if you breastfeed your child. You may need to decide whether to stop breastfeeding or stop taking this medication.

For seniors: The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, a higher amount of a drug stays in your body for a longer time. This raises your risk of side effects.

For children: This medication has not been studied in children younger than 4 years. It should not be used in children of this age range.

All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on:

• your age
• the condition being treated
• how severe your condition is
• other medical conditions you have
• how you react to the first dose

Drug forms and strengths

Generic: Ondansetron

• Form: orally disintegrating tablet
• Strengths: 4 mg, 8 mg

Brand: Zofran ODT

• Form: orally disintegrating tablet
• Strengths: 4 mg, 8 mg
• Dosage for prevention of nausea and vomiting caused by chemotherapy

Adult dosage (ages 18–64 years)

• Typical dosage for chemotherapy that’s highly likely to cause nausea and vomiting: A single 24-mg dose given 30 minutes before chemotherapy.
• Typical dosage for chemotherapy that’s somewhat likely to cause nausea and vomiting: 8 mg, 30 minutes before chemotherapy. Eight hours later, you can take another 8 mg. For 1–2 days after chemotherapy, you can take 8 mg twice per day.

Child dosage (ages 12–17 years)

• Typical dosage for chemotherapy that’s somewhat likely to cause nausea and vomiting: 8 mg given 30 minutes before chemotherapy. Four and eight hours after the first dose, your child can take another 8 mg. For 1–2 days after chemotherapy, they can take 8 mg three times per day.

Child dosage (ages 4–11 years)

• Typical dosage for chemotherapy that’s somewhat likely to cause nausea and vomiting: 4 mg given 30 minutes before chemotherapy. Four and eight hours after the first dose, your child can take another 4 mg. For 1–2 days after chemotherapy, your child can take 4 mg, three times per day.

Child dosage (ages 0–3 years)

It has not been confirmed that ondansetron is safe and effective for use in children younger than 4 years. It should not be used in children of this age range.

Senior dosage (ages 65 years and older)

The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, a higher amount of a drug stays in your body for a longer time. This raises your risk of side effects.

Your doctor may start you on a lowered dosage or a different dosing schedule. This can help keep levels of this drug from building up too much in your body.

Dosage for prevention of nausea and vomiting caused by radiation treatment

Adult dosage (ages 18–64 years)

• Typical dosage: 8 mg starting 1–2 hours before radiation, followed by 8-mg doses every 8 hours after that first dose. Continue for 1 to 2 days after you complete radiation treatment. This dosage may vary depending on the type of radiation you receive.

Child dosage (ages 0–17 years)

It has not been established that this drug is safe and effective for this use in children.

Senior dosage (ages 65 years and older)

The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, a higher amount of a drug stays in your body for a longer time. This raises your risk of side effects.

Your doctor may start you on a lowered dosage or a different dosing schedule. This can help keep levels of this drug from building up too much in your body.

Dosage for prevention of nausea and vomiting caused by surgery

Adult dosage (ages 18–64 years)

• Typical dosage: 16 mg one hour before you receive anesthesia for surgery.

Child dosage (ages 0–17 years)

It has not been established that this drug is safe and effective for this use in children.

Senior dosage (ages 65 years and older)

The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, a higher amount of a drug stays in your body for a longer time. This raises your risk of side effects.

Your doctor may start you on a lowered dosage or a different dosing schedule. This can help keep levels of this drug from building up too much in your body.

Special dosage considerations

For people with liver disease: If you have severe liver disease, you should not take more than 8 mg of ondansetron per day.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always speak with your doctor or pharmacist about dosages that are right for you.

Ondansetron orally disintegrating tablet is used for short-term treatment. It comes with serious risks if you don’t take it as prescribed.

If you stop taking the drug suddenly or don’t take it at all: You could have nausea and vomiting that’s not controlled.

If you take too much: You could have dangerous levels of the drug in your body. Symptoms of an overdose of this drug can include:

• faintness
• drowsiness
• agitation
• fast heartbeat
• flushing (sudden reddening of the skin)
• seizures

If you think you’ve taken too much of this drug, call your doctor or local poison control center. If your symptoms are severe, call 911 or go to the nearest emergency room right away.

How to tell if the drug is working: You should not have nausea or vomiting. If you do, it should be less severe.

Keep these considerations in mind if your doctor prescribes ondansetron for you.

General

• You can take ondansetron with or without food.
• Take this drug at the time(s) recommended by your doctor.
• Do not cut or crush the orally disintegrating tablets.

Storage

• Store the orally disintegrating tablets at a temperature between 36°F and 86°F (2°C and 30°C).
• Keep this drug away from light.
• Don’t store this medication in moist or damp areas, such as bathrooms.

Refills

A prescription for this medication is refillable. You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription.

Travel

When traveling with your medication:

• Always carry your medication with you. When flying, never put it into a checked bag. Keep it in your carry-on bag.
• Don’t worry about airport X-ray machines. They can’t harm your medication.
• You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled container with you.
• Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.

Self-management

• When taking the orally disintegrating tablet out of its package, peel the foil back. Don’t try to push the tablet through the foil. This step will help keep the tablet from breaking.
• Place the tablet on your tongue. Leave it there for a few seconds to allow it to dissolve, and then swallow. You don’t need to take the tablet with liquid.

Availability

Not every pharmacy stocks this drug. When filling your prescription, be sure to call ahead to make sure your pharmacy carries it.

There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

Side Effects, Dosage, Uses, and More

Highlights for ondansetron

1. Ondansetron orally disintegrating tablet is available as a brand-name drug and as a generic drug. Brand name: Zofran ODT.
2. Ondansetron comes in three forms that you take by mouth: a tablet, a disintegrating tablet, and a solution. It’s also available in an intravenous (IV) form. This form is only given by a healthcare professional.
3. Ondansetron orally disintegrating tablet is used to prevent nausea and vomiting caused by certain medical treatments.

• Serotonin syndrome warning: Ondansetron raises your risk of a life-threatening condition called serotonin syndrome. This syndrome occurs when the chemical serotonin builds up too much in your body. A high level of serotonin can cause agitation, delirium (confused thinking) and hallucinations (seeing or hearing things that aren’t real). It can also cause sweating, rapid heartbeat, muscle stiffness, tremor, seizures, jerky muscle movements, and coma. Call your doctor right away if you have any of these symptoms. This condition can result from using ondansetron alone. However, it’s more likely to occur when you’re also taking another drug that affects serotonin levels.

Ondansetron is a prescription drug. It comes in three forms that you take by mouth: a tablet, a disintegrating tablet, and a solution. It’s also available in an intravenous (IV) form, which is only given by a healthcare professional.

Ondansetron orally disintegrating tablet is available as the brand-name drug Zofran ODT. It’s also available as a generic drug. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in every strength or form as the brand-name drug.

Ondansetron may be used as part of a combination therapy. This means you may need to take it with other medications.

Why it’s used

Ondansetron orally disintegrating tablet is used to prevent nausea and vomiting caused by certain medical treatments. These treatments include:

• chemotherapy
• radiation treatment
• surgery

How it works

Ondansetron belongs to a class of drugs called antiemetics. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions. Antiemetics are drugs that reduce nausea and vomiting.

Ondansetron works by blocking the release of the chemical serotonin in the gut and the central nervous system. This keeps serotonin from causing nausea and vomiting.

Ondansetron orally disintegrating tablet may cause drowsiness. It can also cause other side effects.

More common side effects

The more common side effects of ondansetron can include:

• headache
• diarrhea
• constipation
• dizziness
• drowsiness

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

• Serotonin syndrome. Symptoms can include:
  • agitation
  • hallucinations (seeing or hearing things that aren’t real)
  • rapid heartbeat
  • sweating
  • feeling hot
  • muscle rigidity (stiffness)
  • tremor
  • nausea
  • vomiting
  • diarrhea
  • coma

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare professional who knows your medical history.

Ondansetron orally disintegrating tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Examples of drugs that can cause interactions with ondansetron are listed below.

Drugs you should not use with ondansetron

Do not take these drugs with ondansetron. Doing so can cause dangerous effects in your body. Examples of these drugs include:

• Apomorphine. Taking this drug with ondansetron can cause your blood pressure to drop to unsafe levels. This can cause you to pass out.

Interactions that increase your risk of side effects from ondansetron

Taking ondansetron with certain medications raises your risk of side effects from ondansetron. This is because the amount of ondansetron in your body may be increased. Examples of these drugs include:

• Other drugs that affect serotonin levels, such as fluoxetine and paroxetine.

Interactions that can make ondansetron less effective

Taking these drugs with ondansetron can make ondansetron less effective. This is because the amount of ondansetron in your body may be decreased. Examples of these drugs include:

• Anti-seizure drugs, such as phenytoin or carbamazepine. Your doctor may switch you from ondansetron to a different drug if needed.
• Tuberculosis drugs, such as rifampin, rifabutin, or rifapentine. Your doctor may switch you from ondansetron to a different drug if needed.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare professional about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

This drug comes with several warnings.

Allergy warning

Ondansetron can cause a severe allergic reaction. Symptoms can include:

• flushing
• trouble breathing
• swelling of your throat or tongue
• dizziness
• coughing

If you develop these symptoms, call 911 or go to the nearest emergency room.

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

Warnings for people with certain health conditions

For people with risk factors for heart arrhythmias: If you have conditions such as heart failure or congenital long QT syndrome, this drug may increase your risk of arrhythmias. Ask your doctor if you have risk factors for arrhythmias.

For people with phenylketonuria: The ondansetron orally disintegrating tablet contains phenylalanine. This amino acid can cause dangerous effects in people with a condition called phenylketonuria. Don’t take the orally disintegrating tablet if you have phenylketonuria.

Warnings for other groups

For pregnant women: There haven’t been enough studies done in humans to be certain how ondansetron might affect a fetus when the mother takes it. Research in animals has not shown a risk to the fetus. However, animal studies do not always predict the way humans would respond.

Talk to your doctor if you’re pregnant or planning to become pregnant. This drug should only be used in pregnancy if clearly needed.

For women who are breastfeeding: Ondansetron may pass into breast milk and may cause side effects in a child who is breastfed. Talk to your doctor if you breastfeed your child. You may need to decide whether to stop breastfeeding or stop taking this medication.

For seniors: The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, a higher amount of a drug stays in your body for a longer time. This raises your risk of side effects.

For children: This medication has not been studied in children younger than 4 years. It should not be used in children of this age range.

All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on:

• your age
• the condition being treated
• how severe your condition is
• other medical conditions you have
• how you react to the first dose

Drug forms and strengths

Generic: Ondansetron

• Form: orally disintegrating tablet
• Strengths: 4 mg, 8 mg

Brand: Zofran ODT

• Form: orally disintegrating tablet
• Strengths: 4 mg, 8 mg
• Dosage for prevention of nausea and vomiting caused by chemotherapy

Adult dosage (ages 18–64 years)

• Typical dosage for chemotherapy that’s highly likely to cause nausea and vomiting: A single 24-mg dose given 30 minutes before chemotherapy.
• Typical dosage for chemotherapy that’s somewhat likely to cause nausea and vomiting: 8 mg, 30 minutes before chemotherapy. Eight hours later, you can take another 8 mg. For 1–2 days after chemotherapy, you can take 8 mg twice per day.

Child dosage (ages 12–17 years)

• Typical dosage for chemotherapy that’s somewhat likely to cause nausea and vomiting: 8 mg given 30 minutes before chemotherapy. Four and eight hours after the first dose, your child can take another 8 mg. For 1–2 days after chemotherapy, they can take 8 mg three times per day.

Child dosage (ages 4–11 years)

• Typical dosage for chemotherapy that’s somewhat likely to cause nausea and vomiting: 4 mg given 30 minutes before chemotherapy. Four and eight hours after the first dose, your child can take another 4 mg. For 1–2 days after chemotherapy, your child can take 4 mg, three times per day.

Child dosage (ages 0–3 years)

It has not been confirmed that ondansetron is safe and effective for use in children younger than 4 years. It should not be used in children of this age range.

Senior dosage (ages 65 years and older)

The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, a higher amount of a drug stays in your body for a longer time. This raises your risk of side effects.

Your doctor may start you on a lowered dosage or a different dosing schedule. This can help keep levels of this drug from building up too much in your body.

Dosage for prevention of nausea and vomiting caused by radiation treatment

Adult dosage (ages 18–64 years)

• Typical dosage: 8 mg starting 1–2 hours before radiation, followed by 8-mg doses every 8 hours after that first dose. Continue for 1 to 2 days after you complete radiation treatment. This dosage may vary depending on the type of radiation you receive.

Child dosage (ages 0–17 years)

It has not been established that this drug is safe and effective for this use in children.

Senior dosage (ages 65 years and older)

The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, a higher amount of a drug stays in your body for a longer time. This raises your risk of side effects.

Your doctor may start you on a lowered dosage or a different dosing schedule. This can help keep levels of this drug from building up too much in your body.

Dosage for prevention of nausea and vomiting caused by surgery

Adult dosage (ages 18–64 years)

• Typical dosage: 16 mg one hour before you receive anesthesia for surgery.

Child dosage (ages 0–17 years)

It has not been established that this drug is safe and effective for this use in children.

Senior dosage (ages 65 years and older)

The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, a higher amount of a drug stays in your body for a longer time. This raises your risk of side effects.

Your doctor may start you on a lowered dosage or a different dosing schedule. This can help keep levels of this drug from building up too much in your body.

Special dosage considerations

For people with liver disease: If you have severe liver disease, you should not take more than 8 mg of ondansetron per day.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always speak with your doctor or pharmacist about dosages that are right for you.

Ondansetron orally disintegrating tablet is used for short-term treatment. It comes with serious risks if you don’t take it as prescribed.

If you stop taking the drug suddenly or don’t take it at all: You could have nausea and vomiting that’s not controlled.

If you take too much: You could have dangerous levels of the drug in your body. Symptoms of an overdose of this drug can include:

• faintness
• drowsiness
• agitation
• fast heartbeat
• flushing (sudden reddening of the skin)
• seizures

If you think you’ve taken too much of this drug, call your doctor or local poison control center. If your symptoms are severe, call 911 or go to the nearest emergency room right away.

How to tell if the drug is working: You should not have nausea or vomiting. If you do, it should be less severe.

Keep these considerations in mind if your doctor prescribes ondansetron for you.

General

• You can take ondansetron with or without food.
• Take this drug at the time(s) recommended by your doctor.
• Do not cut or crush the orally disintegrating tablets.

Storage

• Store the orally disintegrating tablets at a temperature between 36°F and 86°F (2°C and 30°C).
• Keep this drug away from light.
• Don’t store this medication in moist or damp areas, such as bathrooms.

Refills

A prescription for this medication is refillable. You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription.

Travel

When traveling with your medication:

• Always carry your medication with you. When flying, never put it into a checked bag. Keep it in your carry-on bag.
• Don’t worry about airport X-ray machines. They can’t harm your medication.
• You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled container with you.
• Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.

Self-management

• When taking the orally disintegrating tablet out of its package, peel the foil back. Don’t try to push the tablet through the foil. This step will help keep the tablet from breaking.
• Place the tablet on your tongue. Leave it there for a few seconds to allow it to dissolve, and then swallow. You don’t need to take the tablet with liquid.

Availability

Not every pharmacy stocks this drug. When filling your prescription, be sure to call ahead to make sure your pharmacy carries it.

There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

Oral tablet

Oral Disintegration Tablet or Oral Dissolve Tablet ( ODT ) is a dosage form available for a limited range of over-the-counter (OTC) and prescription drugs. ODTs differ from traditional tablets in that they are designed to be dissolved on the tongue rather than swallowed whole. ^{[1] [2] [3] [4] [5] [6] [7] [8 ] [9] [10] [11]} ODT serves as an alternative dosage form for patients with dysphagia ( difficulty in swallowing) or when compliance is a known problem and therefore a lighter dosage form ensures that the drug is taken. Common among all age groups, dysphagia occurs in approximately 35% of the general population, as well as up to 60% of the elderly institutionalized population ^{[12] [13]} and 18-22% of all patients in long-term care facilities. ^[14] ODTs may have a faster onset of action than tablets or capsules and have the convenience of a tablet that can be taken without water. Over the past decade, ODTs have become available in various therapeutic markets, both OTC and prescription.

Tablets intended to dissolve on the buccal mucosa(s) were the forerunners of ODT. This dosage form was intended for drugs with low bioavailability through the digestive tract, but inconvenient for parenteral administration, such as steroids and narcotic analgesics. ^[15] Buccal absorption allows the drug to bypass the digestive tract for rapid systemic distribution. Not all ODTs are buccally absorbed, and many have the same absorption and bioavailability as standard oral dosage forms, with absorption through the gastrointestinal tract remaining the primary route. However, a fast disintegration time and a small tablet weight may improve buccal absorption. The first ODTs fell apart due to effervescence rather than dissolution, and were designed to make taking vitamins more enjoyable for children. ^[16] This method has been adapted for use in pharmaceuticals with the invention of microparticles containing the drug, which is released when the tablet is effervescent and swallowed by the patient. ^[17] Dissolution has become more efficient than foaming due to improved manufacturing processes and ingredients (such as the addition of mannitol to increase binding and reduce dissolution time). ^[18] Catalent Pharma Solutions (formerly Scherer DDS) in the UK, Cima Labs and Fuisz Technologies (whose founder Richard Fuze went on to develop orally dissolving films, a separate but related dosage form) in the US, and Takeda Pharmaceutical Company in Japan led the development of ODT .

The first ODT drug to receive US Food and Drug Administration (FDA) approval was Zydis ODT Claritin (loratadine) in December 1996. ^[19] This was followed by the Zydis ODT form of klonopin (clonazepam). in December 1997 ^[20] and Maxalta (rizatriptan) Zydis ODT in June 1998 ^[21] The standard condition for meeting the definition of an orally disintegrating tablet is the USP 701 method for disintegration.